Detailed information for compound 901428

Basic information

Technical information
  • TDR Targets ID: 901428
  • Name: methyl 3-[(6-methylquinazolin-4-yl)amino]benz oate
  • MW: 293.32 | Formula: C17H15N3O2
  • H donors: 1 H acceptors: 3 LogP: 3.63 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: COC(=O)c1cccc(c1)Nc1ncnc2c1cc(C)cc2
  • InChi: 1S/C17H15N3O2/c1-11-6-7-15-14(8-11)16(19-10-18-15)20-13-5-3-4-12(9-13)17(21)22-2/h3-10H,1-2H3,(H,18,19,20)
  • InChiKey: YJEQJJSUJVLTFL-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 3-[(6-methyl-4-quinazolinyl)amino]benzoic acid methyl ester
  • 3-[(6-methylquinazolin-4-yl)amino]benzoic acid methyl ester
  • Oprea1_710492
  • Oprea1_521232
  • MLS000519143
  • SMR000129562
  • ZINC00122212

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references
Influenza A virus Nonstructural protein 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Mycobacterium tuberculosis Hypothetical protein Nonstructural protein 1   230 aa 202 aa 23.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus 0.0022 0.003 0.0015
Schistosoma mansoni terminal deoxycytidyl transferase 0.0039 0.008 0.0205
Loa Loa (eye worm) hypothetical protein 0.0036 0.0071 0.0242
Echinococcus multilocularis rhodopsin orphan GPCR 0.0022 0.003 0.0047
Brugia malayi AKH receptor 0.0022 0.003 0.0101
Echinococcus multilocularis inosine 5' monophosphate dehydrogenase 2 0.1003 0.2937 0.4674
Schistosoma mansoni jumonji domain containing protein 0.0055 0.0126 0.0324
Schistosoma mansoni neuropeptide receptor 0.0022 0.003 0.0076
Echinococcus multilocularis Smad4 0.002 0.0025 0.0039
Echinococcus granulosus 7TM GPCR rhodopsin 0.0022 0.003 0.0075
Trichomonas vaginalis alpha-glucosidase, putative 0.0027 0.0043 0.0042
Giardia lamblia PHD finger protein 15 0.0021 0.0026 0.0026
Onchocerca volvulus 0.0086 0.022 0.0883
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0069 0.0169 0.0325
Loa Loa (eye worm) hypothetical protein 0.0022 0.003 0.0101
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0022 0.003 0.0075
Loa Loa (eye worm) hypothetical protein 0.0183 0.0506 0.1724
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0022 0.003 0.0047
Mycobacterium ulcerans hypothetical protein 0.0021 0.0028 0.0057
Schistosoma mansoni aldehyde dehydrogenase 0.0062 0.0147 0.0377
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0086 0.022 0.0883
Leishmania major hypothetical protein, conserved 0.0021 0.0026 0.0088
Loa Loa (eye worm) DR-78 0.0086 0.022 0.0749
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0026 0.004 0.0082
Toxoplasma gondii PHD-finger domain-containing protein 0.0021 0.0026 0.009
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0016 0.0011 0.0039
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0183 0.0506 0.0805
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0012 0.0018
Schistosoma mansoni biogenic amine (5HT) receptor 0.0022 0.003 0.0076
Trypanosoma brucei PAB1-binding protein , putative 0.0021 0.0026 0.0088
Loa Loa (eye worm) hypothetical protein 0.0022 0.003 0.0101
Plasmodium vivax hypothetical protein, conserved 0.0021 0.0026 0.009
Schistosoma mansoni hypothetical protein 0.0022 0.003 0.0076
Trypanosoma brucei DNA polymerase kappa, putative 0.0027 0.0044 0.015
Brugia malayi putative neuropeptide receptor NPR1 0.0022 0.003 0.0101
Schistosoma mansoni amine GPCR 0.0022 0.003 0.0076
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0019 0.0021 0.0042
Brugia malayi Glycosyl hydrolases family 31 protein 0.012 0.0319 0.1085
Brugia malayi Inositol-1 0.0077 0.0193 0.0659
Loa Loa (eye worm) hypothetical protein 0.0097 0.0251 0.0853
Onchocerca volvulus 0.0022 0.003 0.0015
Schistosoma mansoni tar DNA-binding protein 0.0104 0.0273 0.0699
Mycobacterium leprae Probable inosine-5'-monophosphate dehydrogenase GuaB3 (IMP dehydrogenase 2) (inosinic acid dehydrogenase) (inosinate dehydrogena 0.0557 0.1616 0.3305
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0022 0.003 0.0076
Giardia lamblia DINP protein human, muc B family 0.0039 0.008 0.008
Echinococcus multilocularis neuropeptide receptor 0.0022 0.003 0.0047
Brugia malayi G protein-coupled receptor F59B2.13 0.0022 0.003 0.0101
Brugia malayi hypothetical protein 0.0106 0.0278 0.0946
Echinococcus granulosus tar DNA binding protein 0.0104 0.0273 0.0698
Loa Loa (eye worm) hypothetical protein 0.0086 0.022 0.0749
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0069 0.0169 0.0347
Echinococcus granulosus g-protein coupled receptor 0.0022 0.003 0.0075
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0022 0.003 0.0047
Loa Loa (eye worm) hypothetical protein 0.017 0.0469 0.1598
Brugia malayi GnHR receptor homolog 0.0022 0.003 0.0101
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0126 0.0337 0.1148
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0083 0.0209 0.0332
Schistosoma mansoni lamin 0.0047 0.0104 0.0268
Brugia malayi isocitrate dehydrogenase 0.0016 0.0012 0.004
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0173 0.0476 0.0757
Loa Loa (eye worm) hypothetical protein 0.0183 0.0506 0.1724
Loa Loa (eye worm) nuclear hormone receptor 0.0086 0.022 0.0749
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0183 0.0506 0.1724
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0027 0.0043 0.0042
Toxoplasma gondii exonuclease III APE 0.0012 0 0.0001
Brugia malayi G protein-coupled receptor 0.0022 0.003 0.0101
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0069 0.0168 0.0345
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0083 0.0209 0.0712
Brugia malayi G-protein coupled receptor 0.0022 0.003 0.0101
Echinococcus granulosus dna polymerase kappa 0.0039 0.008 0.0204
Brugia malayi beta-lactamase family protein 0.017 0.0469 0.1598
Brugia malayi PHD-finger family protein 0.0021 0.0026 0.009
Echinococcus multilocularis thioredoxin glutathione reductase 0.003 0.0053 0.0084
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0062 0.0147 0.0376
Brugia malayi Isocitrate dehydrogenase 0.0016 0.0012 0.004
Brugia malayi RNA binding protein 0.0104 0.0273 0.0928
Onchocerca volvulus 0.017 0.0469 0.2021
Schistosoma mansoni neuropeptide F-like receptor 0.0022 0.003 0.0076
Brugia malayi intermediate filament protein 0.0047 0.0104 0.0355
Trypanosoma cruzi DNA polymerase kappa, putative 0.0039 0.008 0.0273
Echinococcus granulosus neuropeptide Y receptor 0.0022 0.003 0.0075
Loa Loa (eye worm) hypothetical protein 0.0086 0.022 0.0749
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0183 0.0506 0.1724
Schistosoma mansoni myosin xvIII 0.0022 0.003 0.0076
Schistosoma mansoni biogenic amine (5HT) receptor 0.0022 0.003 0.0076
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0046 0.0099 0.0337
Mycobacterium tuberculosis Conserved hypothetical protein 0.014 0.0379 0.0779
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0183 0.0506 0.0805
Treponema pallidum fructose-bisphosphate aldolase 0.3385 1 1
Plasmodium vivax arginase, putative 0.0219 0.0615 0.2103
Loa Loa (eye worm) intermediate filament protein 0.0047 0.0104 0.0355
Brugia malayi MH1 domain containing protein 0.002 0.0025 0.0084
Echinococcus multilocularis tar DNA binding protein 0.0104 0.0273 0.0433
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0183 0.0506 0.1724
Schistosoma mansoni serine/threonine protein kinase 0.0134 0.0362 0.0929
Echinococcus granulosus g protein coupled receptor 0.0022 0.003 0.0075
Plasmodium vivax inosine-5'-monophosphate dehydrogenase, putative 0.0998 0.2923 1
Echinococcus multilocularis orexin receptor type 2 0.0022 0.003 0.0047
Schistosoma mansoni opsin-like receptor 0.0022 0.003 0.0076
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0026 0.004 0.0081
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0183 0.0506 0.0805
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0086 0.022 0.0749
Trypanosoma cruzi GMP reductase 0.1003 0.2937 1
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0012 0.004
Echinococcus granulosus Nuclear hormone receptor HR96 0.0086 0.022 0.0563
Loa Loa (eye worm) hypothetical protein 0.0022 0.003 0.0101
Brugia malayi Serotonin receptor 0.0022 0.003 0.0101
Mycobacterium leprae conserved hypothetical protein 0.017 0.0469 0.0943
Schistosoma mansoni neuropeptide receptor 0.0022 0.003 0.0076
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0077 0.0193 0.0659
Loa Loa (eye worm) hypothetical protein 0.0183 0.0506 0.1724
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0027 0.0043 0.0042
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0083 0.0209 0.0535
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0026 0.004 0.0058
Loa Loa (eye worm) hypothetical protein 0.0086 0.022 0.0749
Trypanosoma brucei unspecified product 0.0027 0.0044 0.015
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0012 0.004
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0069 0.0168 0.0345
Loa Loa (eye worm) hypothetical protein 0.0022 0.003 0.0101
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0086 0.022 0.0349
Loa Loa (eye worm) hypothetical protein 0.0086 0.022 0.0749
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.004 0.0082
Loa Loa (eye worm) hypothetical protein 0.0022 0.003 0.0101
Loa Loa (eye worm) hypothetical protein 0.0022 0.003 0.0101
Loa Loa (eye worm) glutaminase 2 0.0278 0.0788 0.2683
Echinococcus granulosus rhodopsin orphan GPCR 0.0022 0.003 0.0075
Trichomonas vaginalis Citrate lyase beta chain, putative 0.0021 0.0028 0.0027
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0022 0.003 0.0076
Echinococcus granulosus intermediate filament protein 0.0047 0.0104 0.0267
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0086 0.022 0.0349
Onchocerca volvulus 0.0022 0.003 0.0015
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0022 0.003 0.0047
Mycobacterium ulcerans hypothetical protein 0.014 0.0379 0.0779
Onchocerca volvulus 0.0022 0.003 0.0015
Loa Loa (eye worm) hypothetical protein 0.0183 0.0506 0.1724
Toxoplasma gondii ABC1 family protein 0.017 0.0469 0.1598
Loa Loa (eye worm) hypothetical protein 0.0097 0.0251 0.0853
Loa Loa (eye worm) hypothetical protein 0.0022 0.003 0.0101
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0027 0.0043 0.0145
Echinococcus granulosus L aminoadipate semialdehyde 0.0057 0.0133 0.0339
Loa Loa (eye worm) hypothetical protein 0.0022 0.003 0.0101
Giardia lamblia Fructose-bisphosphate aldolase 0.3385 1 1
Echinococcus granulosus somatostatin receptor 0.0022 0.003 0.0075
Echinococcus granulosus tm gpcr rhodopsin 0.0022 0.003 0.0075
Trichomonas vaginalis CAMK family protein kinase 0.0067 0.0161 0.0161
Echinococcus granulosus neuropeptide receptor 0.0022 0.003 0.0075
Schistosoma mansoni opsin-like receptor 0.0022 0.003 0.0076
Echinococcus granulosus neuropeptide receptor 0.0022 0.003 0.0075
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0668 0.1945 0.6621
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0183 0.0506 0.1299
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.1003 0.2937 1
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0096 0.0249 0.0396
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.004 0.0082
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0077 0.0191 0.0369
Brugia malayi photoreceptor-specific nuclear receptor 0.0183 0.0506 0.1724
Echinococcus multilocularis allatostatin A receptor 0.0022 0.003 0.0047
Echinococcus granulosus allatostatin A receptor 0.0022 0.003 0.0075
Echinococcus granulosus biogenic amine 5HT receptor 0.0022 0.003 0.0075
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0012 0 0.0001
Brugia malayi nuclear receptor RXR 0.0086 0.022 0.0749
Trypanosoma cruzi hypothetical protein, conserved 0.0186 0.0516 0.1757
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0104 0.0273 0.0928
Trypanosoma brucei DNA polymerase IV, putative 0.0039 0.008 0.0273
Brugia malayi Pre-SET motif family protein 0.0668 0.1945 0.6621
Trichomonas vaginalis alpha-glucosidase, putative 0.0027 0.0043 0.0042
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.008 0.0273
Plasmodium vivax hypothetical protein, conserved 0.017 0.0469 0.1606
Schistosoma mansoni neuropeptide F-like receptor 0.0022 0.003 0.0076
Schistosoma mansoni growth hormone secretagogue receptor 0.0022 0.003 0.0076
Trypanosoma brucei DNA polymerase IV, putative 0.0039 0.008 0.0273
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0183 0.0506 0.1724
Schistosoma mansoni steroid hormone receptor ad4bp 0.0183 0.0506 0.1299
Echinococcus multilocularis neuropeptide Y receptor 0.0022 0.003 0.0047
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.008 0.0273
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0022 0.003 0.0076
Loa Loa (eye worm) hypothetical protein 0.0022 0.003 0.0101
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0183 0.0506 0.1724
Brugia malayi Nuclear hormone receptor-like 1 0.0097 0.0251 0.0853
Echinococcus granulosus dna polymerase eta 0.0039 0.008 0.0204
Onchocerca volvulus 0.0047 0.0104 0.0356
Echinococcus multilocularis citrate lyase subunit beta protein 0.0021 0.0028 0.0043
Echinococcus multilocularis rhodopsin orphan GPCR 0.0022 0.003 0.0047
Echinococcus granulosus neuropeptides capa receptor 0.0022 0.003 0.0075
Echinococcus multilocularis lysine specific demethylase 5A 0.0025 0.004 0.0062
Brugia malayi hypothetical protein 0.0022 0.003 0.0101
Schistosoma mansoni ap endonuclease 0.0012 0 0.0001
Schistosoma mansoni zinc finger protein 0.0086 0.022 0.0564
Onchocerca volvulus Bile acid receptor homolog 0.0183 0.0506 0.219
Schistosoma mansoni nuclear receptor 0.0086 0.022 0.0564
Echinococcus multilocularis serotonin receptor 0.0022 0.003 0.0047
Brugia malayi hypothetical protein 0.0086 0.022 0.0749
Loa Loa (eye worm) hypothetical protein 0.0026 0.004 0.0136
Trypanosoma cruzi DNA polymerase eta, putative 0.0039 0.008 0.0273
Mycobacterium ulcerans DNA polymerase IV 0.0039 0.008 0.0164
Echinococcus multilocularis neuropeptides capa receptor 0.0022 0.003 0.0047
Brugia malayi Bromodomain containing protein 0.0021 0.0026 0.009
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.004 0.0136
Loa Loa (eye worm) hypothetical protein 0.0086 0.022 0.0749
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0022 0.003 0.0076
Trichomonas vaginalis CAMK family protein kinase 0.0134 0.0362 0.0362
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0097 0.0251 0.0643
Entamoeba histolytica acyl-CoA synthetase, putative 0.0026 0.004 0.0039
Brugia malayi nuclear receptor NHR-67 0.0086 0.022 0.0749
Loa Loa (eye worm) hypothetical protein 0.0026 0.004 0.0136
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0077 0.0193 0.0659
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0016 0.0011 0.0023
Brugia malayi ORL1-like opioid receptor 0.0022 0.003 0.0101
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0022 0.003 0.0047
Schistosoma mansoni intermediate filament proteins 0.0047 0.0104 0.0268
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.004 0.0082
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0183 0.0506 0.1724
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0083 0.0209 0.0332
Trypanosoma cruzi DNA polymerase kappa, putative 0.0039 0.008 0.0273
Loa Loa (eye worm) hypothetical protein 0.0021 0.0026 0.009
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.0147 0.0302
Brugia malayi Tachykinin-like peptides receptor 99D 0.0022 0.003 0.0101
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.008 0.0273
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0096 0.0249 0.0849
Echinococcus granulosus lamin dm0 0.0047 0.0104 0.0267
Loa Loa (eye worm) hypothetical protein 0.0086 0.022 0.0749
Loa Loa (eye worm) hypothetical protein 0.0022 0.003 0.0101
Echinococcus multilocularis rhodopsin orphan GPCR 0.0022 0.003 0.0047
Echinococcus granulosus thyroid hormone receptor alpha 0.0086 0.022 0.0563
Trypanosoma cruzi hypothetical protein, conserved 0.0027 0.0043 0.0145
Schistosoma mansoni hypothetical protein 0.1327 0.3899 1
Echinococcus granulosus neutral alpha glucosidase AB 0.0027 0.0043 0.0109
Loa Loa (eye worm) hypothetical protein 0.0022 0.003 0.0101
Brugia malayi ecdysteroid receptor 0.0183 0.0506 0.1724
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0012 0.004
Onchocerca volvulus 0.0022 0.003 0.0015
Mycobacterium ulcerans lipase LipD 0.017 0.0469 0.0965
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.004 0.0136
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0022 0.003 0.0075
Trypanosoma brucei hypothetical protein, conserved 0.017 0.0469 0.1598
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0086 0.022 0.0563
Brugia malayi putative neuropeptide receptor 0.0022 0.003 0.0101
Loa Loa (eye worm) hypothetical protein 0.0019 0.0021 0.007
Entamoeba histolytica acyl-coA synthetase, putative 0.0026 0.004 0.0039
Schistosoma mansoni transcription factor LCR-F1 0.0106 0.0278 0.0712
Schistosoma mansoni DNA polymerase eta 0.0039 0.008 0.0205
Trichomonas vaginalis maltase-glucoamylase, putative 0.0027 0.0043 0.0042
Trypanosoma cruzi polo-like protein kinase, putative 0.0134 0.0362 0.1234
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0173 0.0476 0.122
Loa Loa (eye worm) G-protein coupled receptor 0.0022 0.003 0.0101
Schistosoma mansoni neuropeptide receptor 0.0022 0.003 0.0076
Schistosoma mansoni opsin-like receptor 0.0022 0.003 0.0076
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0022 0.003 0.0075
Echinococcus granulosus lysine specific demethylase 5A 0.0027 0.0043 0.011
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0022 0.003 0.0076
Loa Loa (eye worm) TYRA-2 protein 0.0022 0.003 0.0101
Brugia malayi hypothetical protein 0.0021 0.0026 0.0088
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0086 0.022 0.0749
Loa Loa (eye worm) hypothetical protein 0.0022 0.003 0.0101
Toxoplasma gondii LsmAD domain-containing protein 0.0021 0.0026 0.0088
Echinococcus multilocularis somatostatin receptor 0.0022 0.003 0.0047
Brugia malayi hypothetical protein 0.0086 0.022 0.0749
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0096 0.0249 0.0639
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0183 0.0506 0.1724
Echinococcus granulosus G protein coupled receptor 139 0.0022 0.003 0.0075
Trypanosoma cruzi agmatinase, putative 0.008 0.0201 0.0683
Trichomonas vaginalis glutaminase, putative 0.0278 0.0788 0.0788
Loa Loa (eye worm) hypothetical protein 0.0183 0.0506 0.1724
Echinococcus granulosus neuropeptide receptor A26 0.0022 0.003 0.0075
Loa Loa (eye worm) hypothetical protein 0.0022 0.0029 0.0099
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0183 0.0506 0.1299
Echinococcus granulosus hypothetical protein 0.0022 0.003 0.0075
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0134 0.0362 0.1234
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.3385 1 1
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0025 0.0039 0.0133
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0022 0.003 0.0076
Schistosoma mansoni smad1 5 8 and 0.002 0.0025 0.0063
Onchocerca volvulus 0.0022 0.003 0.0015
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0077 0.0193 0.0193
Brugia malayi hypothetical protein 0.0022 0.003 0.0101
Trichomonas vaginalis alpha-glucosidase, putative 0.0027 0.0043 0.0042
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.3385 1 1
Echinococcus multilocularis smad 0.002 0.0025 0.0039
Schistosoma mansoni thyroid hormone receptor 0.0183 0.0506 0.1299
Echinococcus multilocularis rhodopsin orphan GPCR 0.0022 0.003 0.0047
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0016 0.0012 0.0029
Loa Loa (eye worm) hypothetical protein 0.0086 0.022 0.0749
Loa Loa (eye worm) hypothetical protein 0.0096 0.0249 0.0849
Echinococcus multilocularis g-protein coupled receptor 0.0022 0.003 0.0047
Brugia malayi nuclear receptor NHR-88 0.0086 0.022 0.0749
Trypanosoma cruzi polo-like protein kinase, putative 0.0134 0.0362 0.1234
Schistosoma mansoni biogenic amine receptor 0.0022 0.003 0.0076
Mycobacterium tuberculosis Probable hydrolase 0.017 0.0469 0.0964
Loa Loa (eye worm) hypothetical protein 0.017 0.0469 0.1598
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0173 0.0476 0.122
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0086 0.022 0.0349
Onchocerca volvulus 0.017 0.0469 0.2021
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.008 0.0273
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0083 0.0209 0.0535
Entamoeba histolytica hypothetical protein 0.0106 0.0278 0.0277
Trichomonas vaginalis CAMK family protein kinase 0.0134 0.0362 0.0362
Brugia malayi glutaminase DH11.1 0.0278 0.0788 0.2683
Loa Loa (eye worm) hypothetical protein 0.0022 0.003 0.0101
Echinococcus multilocularis neuropeptides capa receptor 0.0022 0.003 0.0047
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0077 0.0193 0.0193
Schistosoma mansoni biogenic amine receptor 0.0022 0.003 0.0076
Trichomonas vaginalis CAMK family protein kinase 0.0134 0.0362 0.0362
Echinococcus multilocularis rhodopsin orphan GPCR 0.0022 0.003 0.0047
Mycobacterium tuberculosis Conserved protein 0.0021 0.0028 0.0056
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0016 0.0012 0.004
Loa Loa (eye worm) hypothetical protein 0.048 0.1387 0.4722
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0022 0.003 0.0076
Echinococcus multilocularis musashi 0.0047 0.0104 0.0166
Schistosoma mansoni hypothetical protein 0.0083 0.0209 0.0536
Schistosoma mansoni inosine-5-monophosphate dehydrogenase 0.1003 0.2937 0.7532
Loa Loa (eye worm) hypothetical protein 0.0022 0.003 0.0101
Onchocerca volvulus Protein ultraspiracle homolog 0.0183 0.0506 0.219
Trichomonas vaginalis alpha-glucosidase, putative 0.0027 0.0043 0.0042
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0069 0.0169 0.0431
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0022 0.003 0.0076
Loa Loa (eye worm) hypothetical protein 0.0022 0.003 0.0101
Onchocerca volvulus 0.0057 0.0133 0.0485
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0026 0.004 0.0082
Brugia malayi nuclear hormone receptor family member odr-7 0.0086 0.022 0.0749
Loa Loa (eye worm) hypothetical protein 0.0022 0.003 0.0101
Loa Loa (eye worm) hypothetical protein 0.0097 0.0251 0.0853
Brugia malayi Nuclear hormone receptor E75 0.0086 0.022 0.0749
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.3385 1 1
Onchocerca volvulus 0.0022 0.003 0.0015
Echinococcus multilocularis nuclear receptor nhr 48 0.0086 0.022 0.0349
Onchocerca volvulus 0.0022 0.003 0.0015
Brugia malayi sulfakinin receptor protein 0.0228 0.064 0.218
Schistosoma mansoni inositol monophosphatase 0.0077 0.0193 0.0496
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0173 0.0476 0.122
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0106 0.0278 0.0712
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0022 0.003 0.0101
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0022 0.003 0.0075
Loa Loa (eye worm) hypothetical protein 0.0179 0.0493 0.168
Schistosoma mansoni Smad4 0.002 0.0025 0.0063
Echinococcus multilocularis TGF beta signal transducer SmadC 0.002 0.0025 0.0039
Trypanosoma brucei unspecified product 0.0027 0.0044 0.015
Trypanosoma cruzi GMP reductase 0.1003 0.2937 1
Loa Loa (eye worm) hypothetical protein 0.0097 0.0251 0.0853
Echinococcus granulosus TGF beta signal transducer SmadC 0.002 0.0025 0.0063
Loa Loa (eye worm) hypothetical protein 0.0046 0.0102 0.0347
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0018 0.0035
Loa Loa (eye worm) hypothetical protein 0.0022 0.003 0.0101
Brugia malayi serine/threonine-protein kinase plk-2 0.0134 0.0362 0.1234
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0183 0.0506 0.0805
Schistosoma mansoni hypothetical protein 0.0083 0.0209 0.0536
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0173 0.0476 0.162
Echinococcus granulosus fmrfamide receptor 0.0022 0.003 0.0075
Schistosoma mansoni nuclear hormone receptor 0.0183 0.0506 0.1299
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0012 0.0018
Schistosoma mansoni alpha-glucosidase 0.0103 0.0269 0.0691
Mycobacterium ulcerans hypothetical protein 0.0021 0.0028 0.0057
Echinococcus granulosus GPCR family 2 0.0083 0.0209 0.0535
Plasmodium vivax thioredoxin reductase, putative 0.003 0.0053 0.0183
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0097 0.0251 0.0853
Echinococcus multilocularis L aminoadipate semialdehyde 0.0057 0.0133 0.0211
Trichomonas vaginalis penicillin-binding protein, putative 0.017 0.0469 0.0469
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0022 0.003 0.0076
Loa Loa (eye worm) hypothetical protein 0.0022 0.003 0.0101
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0016 0.0011 0.0023
Brugia malayi ImpB/MucB/SamB family protein 0.0039 0.008 0.0273
Brugia malayi Nuclear hormone receptor-like 1 0.0183 0.0506 0.1724
Brugia malayi hypothetical protein 0.0097 0.0251 0.0853
Echinococcus multilocularis lysosomal alpha glucosidase 0.012 0.0319 0.0507
Onchocerca volvulus 0.0183 0.0506 0.219
Trypanosoma brucei DNA polymerase kappa, putative 0.0027 0.0044 0.015
Mycobacterium ulcerans DNA polymerase IV 0.0039 0.008 0.0164
Toxoplasma gondii IMP dehydrogenas 0.1003 0.2937 1
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0022 0.003 0.0076
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.003 0.0053 0.0109
Brugia malayi TAR-binding protein 0.0104 0.0273 0.0928
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.004 0.0136
Brugia malayi orphan nuclear receptor NR2E1 0.0086 0.022 0.0749
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0018 0.0035
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0134 0.0362 0.0928
Loa Loa (eye worm) hypothetical protein 0.0022 0.003 0.0101
Entamoeba histolytica deoxycytidyl transferase, putative 0.0039 0.008 0.008
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0021 0.0026 0.0068
Brugia malayi hypothetical protein 0.0022 0.003 0.0101
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0027 0.0043 0.0145
Echinococcus multilocularis serotonin receptor 0.0022 0.003 0.0047
Trichomonas vaginalis CAMK family protein kinase 0.0134 0.0362 0.0362
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.0147 0.0302
Echinococcus multilocularis G-protein coupled receptor, putative 0.0022 0.003 0.0047
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.0021 0.0028 0.0057
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0173 0.0476 0.122
Loa Loa (eye worm) hypothetical protein 0.0021 0.0026 0.0088
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0022 0.003 0.0047
Mycobacterium tuberculosis Probable lipase LipD 0.017 0.0469 0.0964
Loa Loa (eye worm) hypothetical protein 0.0022 0.003 0.0101
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.0021 0.0028 0.0057
Echinococcus granulosus Smad4 0.002 0.0025 0.0063
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.3385 1 1
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0037 0.0075 0.0255
Loa Loa (eye worm) hypothetical protein 0.0097 0.0251 0.0853
Brugia malayi cytoplasmic intermediate filament protein 0.0025 0.0039 0.0133
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.3385 1 1
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0086 0.022 0.0563
Loa Loa (eye worm) hypothetical protein 0.0086 0.022 0.0749
Plasmodium falciparum ataxin-2 like protein, putative 0.0021 0.0026 0.0089
Loa Loa (eye worm) hypothetical protein 0.0183 0.0506 0.1724
Echinococcus granulosus 7tm_1 domain containing protein 0.0022 0.003 0.0075
Entamoeba histolytica hypothetical protein 0.0106 0.0278 0.0277
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0022 0.003 0.0047
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0077 0.0191 0.0391
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0039 0.008 0.0205
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0021 0.0028 0.0094
Trichomonas vaginalis CAMK family protein kinase 0.0134 0.0362 0.0362
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0183 0.0506 0.1298
Onchocerca volvulus 0.0022 0.003 0.0015
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0012 0 0.0001
Loa Loa (eye worm) melatonin receptor type 1A 0.0022 0.003 0.0101
Echinococcus multilocularis g protein coupled receptor 0.0022 0.003 0.0047
Echinococcus multilocularis G protein coupled receptor 139 0.0022 0.003 0.0047
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0039 0.008 0.0127
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0183 0.0506 0.1299
Loa Loa (eye worm) hypothetical protein 0.0183 0.0506 0.1724
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0026 0.004 0.0081
Schistosoma mansoni hypothetical protein 0.1327 0.3899 1
Echinococcus multilocularis dro:myosuppressin receptor 0.0022 0.003 0.0047
Onchocerca volvulus 0.0022 0.003 0.0015
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0022 0.003 0.0101
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0018 0.0035
Echinococcus granulosus neuropeptides capa receptor 0.0022 0.003 0.0075
Loa Loa (eye worm) hypothetical protein 0.0019 0.0021 0.007
Trichomonas vaginalis esterase, putative 0.017 0.0469 0.0469
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.1003 0.2937 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0022 0.003 0.0075
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0019 0.0021 0.0042
Trypanosoma cruzi DNA polymerase kappa, putative 0.0039 0.008 0.0273
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0086 0.022 0.0349
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0086 0.022 0.0564
Schistosoma mansoni tar DNA-binding protein 0.0104 0.0273 0.0699
Leishmania major hypothetical protein, conserved 0.017 0.0469 0.1598
Echinococcus multilocularis neutral alpha glucosidase AB 0.0027 0.0043 0.0067
Schistosoma mansoni jumonji/arid domain-containing protein 0.0027 0.0043 0.0111
Brugia malayi hypothetical protein 0.0022 0.003 0.0101
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0012 0.0018
Schistosoma mansoni tar DNA-binding protein 0.0104 0.0273 0.0699
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0016 0.0011 0.0039
Brugia malayi ecdysone receptor 0.0086 0.022 0.0749
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0266 0.0753 0.2562
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0037 0.0075 0.0255
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0096 0.0249 0.0639
Echinococcus granulosus smad 0.002 0.0025 0.0063
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0039 0.008 0.0273
Echinococcus granulosus neuropeptide Y receptor 0.0022 0.003 0.0075
Loa Loa (eye worm) hypothetical protein 0.0022 0.003 0.0101
Brugia malayi nuclear receptor NHR-88 0.0183 0.0506 0.1724
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0077 0.0193 0.0398
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0026 0.004 0.0082
Loa Loa (eye worm) glutaminase 0.0278 0.0788 0.2683
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0183 0.0506 0.1298
Echinococcus granulosus g protein coupled receptor 0.0022 0.003 0.0075
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0183 0.0506 0.1298
Onchocerca volvulus 0.076 0.2218 1
Loa Loa (eye worm) G-protein coupled receptor 0.0022 0.003 0.0101
Loa Loa (eye worm) hypothetical protein 0.0022 0.0029 0.0099
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0261 0.0738 0.2514
Echinococcus granulosus cpg binding protein 0.0022 0.003 0.0076
Loa Loa (eye worm) IMP dehydrogenase 1 0.1003 0.2937 1
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.017 0.0469 0.1598
Entamoeba histolytica hypothetical protein 0.0106 0.0278 0.0277
Echinococcus granulosus tm gpcr rhodopsin 0.0022 0.003 0.0075
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0022 0.003 0.0076
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0.0012 0.003
Echinococcus multilocularis neuropeptide s receptor 0.0022 0.003 0.0047
Mycobacterium tuberculosis Probable esterase LipL 0.017 0.0469 0.0964
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.017 0.0469 0.1204
Loa Loa (eye worm) hypothetical protein 0.0026 0.004 0.0136
Loa Loa (eye worm) TAR-binding protein 0.0104 0.0273 0.0928
Schistosoma mansoni smad1 5 8 and 0.002 0.0025 0.0063
Trypanosoma brucei hypothetical protein, conserved 0.0186 0.0516 0.1757
Brugia malayi nuclear hormone receptor 0.0183 0.0506 0.1724
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.008 0.0273
Mycobacterium ulcerans inosine 5'-monophosphate dehydrogenase 0.1003 0.2937 0.6035
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.1653 0.4867 1
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0037 0.0075 0.0255
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0183 0.0506 0.1299
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0048 0.0107 0.0274
Onchocerca volvulus 0.0022 0.003 0.0015
Loa Loa (eye worm) hypothetical protein 0.0022 0.003 0.0101
Brugia malayi exodeoxyribonuclease III family protein 0.0012 0 0.0001
Schistosoma mansoni smad 0.002 0.0025 0.0063
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0012 0 0.0001
Entamoeba histolytica hypothetical protein 0.0106 0.0278 0.0277
Schistosoma mansoni biogenic amine receptor 0.0022 0.003 0.0076
Brugia malayi Latrophilin receptor protein 2 0.0083 0.0209 0.0712
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.017 0.0469 0.1204
Echinococcus multilocularis g protein coupled receptor 0.0022 0.003 0.0047
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0069 0.0168 0.0345
Schistosoma mansoni thyroid hormone receptor 0.0183 0.0506 0.1299
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0183 0.0506 0.1724
Schistosoma mansoni alpha-1 adrenergic receptor 0.0022 0.003 0.0076
Brugia malayi glutathione reductase 0.003 0.0053 0.0182
Brugia malayi tailless protein 0.0086 0.022 0.0749
Echinococcus granulosus lysosomal alpha glucosidase 0.012 0.0319 0.0816
Brugia malayi follicle stimulating hormone receptor 0.0022 0.003 0.0101
Brugia malayi Thioredoxin reductase 0.003 0.0053 0.0182
Trypanosoma brucei agmatinase, putative 0.008 0.0201 0.0683
Echinococcus granulosus orexin receptor type 2 0.0022 0.003 0.0075
Echinococcus multilocularis isocitrate dehydrogenase 0.0016 0.0012 0.0018
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.3385 1 1
Onchocerca volvulus 0.0022 0.003 0.0015
Onchocerca volvulus 0.0086 0.022 0.0883
Brugia malayi hypothetical protein 0.0022 0.003 0.0101
Trypanosoma brucei trypanothione reductase 0.003 0.0053 0.0182
Brugia malayi RE15519p 0.0022 0.003 0.0101
Echinococcus multilocularis fmrfamide receptor 0.0022 0.003 0.0047
Loa Loa (eye worm) hypothetical protein 0.0086 0.022 0.0749
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0016 0.0011 0.0039
Echinococcus multilocularis inositol monophosphatase 1 0.0077 0.0193 0.0307
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0183 0.0506 0.1298
Loa Loa (eye worm) hypothetical protein 0.017 0.0469 0.1598
Leishmania major mitochondrial DNA polymerase beta 0.0266 0.0753 0.2562
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0022 0.003 0.0047
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0069 0.0168 0.0345
Mycobacterium tuberculosis Probable reductase 0.0069 0.0168 0.0345
Brugia malayi Serotonin receptor 0.0022 0.003 0.0101
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0183 0.0506 0.0805
Trypanosoma cruzi arginase, putative 0.008 0.0201 0.0683
Brugia malayi Pre-SET motif family protein 0.0096 0.0249 0.0849
Echinococcus granulosus nuclear receptor nhr 48 0.0086 0.022 0.0563
Onchocerca volvulus 0.0022 0.003 0.0015
Trichomonas vaginalis set domain proteins, putative 0.076 0.2218 0.2218
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0183 0.0506 0.0805
Brugia malayi jmjC domain containing protein 0.0027 0.0043 0.0147
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0022 0.003 0.0075
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0096 0.0249 0.0639
Trypanosoma brucei DNA polymerase IV, putative 0.0039 0.008 0.0273
Loa Loa (eye worm) RNA binding protein 0.0104 0.0273 0.0928
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.017 0.0469 0.0965
Echinococcus multilocularis peregrin 0.0021 0.0026 0.0041
Leishmania major trypanothione reductase 0.003 0.0053 0.0182
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.017 0.0469 0.1598
Loa Loa (eye worm) hypothetical protein 0.0019 0.0021 0.007
Loa Loa (eye worm) hypothetical protein 0.0022 0.003 0.0101
Plasmodium falciparum ataxin-2 like protein, putative 0.0021 0.0026 0.0089
Echinococcus granulosus rhodopsin orphan GPCR 0.0022 0.003 0.0075
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.008 0.0273
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0097 0.0251 0.0643
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0022 0.003 0.0101
Echinococcus multilocularis FTZ F1 alpha 0.0183 0.0506 0.0805
Brugia malayi hypothetical protein 0.0022 0.003 0.0101
Brugia malayi hypothetical protein 0.0022 0.003 0.0101
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0016 0.0011 0.0023
Onchocerca volvulus 0.0022 0.003 0.0015
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0016 0.0011 0.0011
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0039 0.008 0.0204
Mycobacterium tuberculosis Conserved protein 0.017 0.0469 0.0964
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0039 0.008 0.008
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0062 0.0147 0.0301
Toxoplasma gondii aldehyde dehydrogenase 0.0062 0.0147 0.0501
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0012 0 0.0001
Trypanosoma cruzi arginase, putative 0.008 0.0201 0.0683
Trypanosoma cruzi hypothetical protein, conserved 0.0027 0.0043 0.0145
Schistosoma mansoni hypothetical protein 0.0022 0.003 0.0076
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0173 0.0476 0.162
Schistosoma mansoni nuclear receptor nhr-48 0.0086 0.022 0.0564
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.1653 0.4867 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0183 0.0506 0.1724
Entamoeba histolytica Arginase, putative 0.0219 0.0615 0.0614
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0022 0.003 0.0101
Loa Loa (eye worm) hypothetical protein 0.0022 0.003 0.0101
Brugia malayi neuropeptide F receptor 0.0022 0.003 0.0101
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0012 0 0.0001
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0016 0.0012 0.004
Schistosoma mansoni hypothetical protein 0.0083 0.0209 0.0536
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0077 0.0193 0.0659
Schistosoma mansoni cpg binding protein 0.0022 0.003 0.0077
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.1003 0.2937 1
Entamoeba histolytica acyl-CoA synthetase, putative 0.0026 0.004 0.0039
Brugia malayi hypothetical protein 0.048 0.1387 0.4722
Loa Loa (eye worm) hypothetical protein 0.0086 0.022 0.0749
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0096 0.0249 0.0639
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0077 0.0193 0.0659
Echinococcus granulosus inositol monophosphatase 1 0.0077 0.0193 0.0495
Schistosoma mansoni hypothetical protein 0.0106 0.0278 0.0712
Loa Loa (eye worm) nuclear receptor NHR-67 0.0086 0.022 0.0749
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0183 0.0506 0.219
Echinococcus multilocularis neuropeptide FF receptor 2 0.0022 0.003 0.0047
Loa Loa (eye worm) hypothetical protein 0.0057 0.0133 0.0452
Loa Loa (eye worm) hypothetical protein 0.0022 0.003 0.0101
Schistosoma mansoni amine GPCR 0.0022 0.003 0.0076
Schistosoma mansoni smad1 5 8 and 0.002 0.0025 0.0063
Schistosoma mansoni hypothetical protein 0.0022 0.003 0.0076
Echinococcus multilocularis rhodopsin orphan GPCR 0.0022 0.003 0.0047
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0019 0.0021 1
Loa Loa (eye worm) hypothetical protein 0.0023 0.0032 0.0108
Trypanosoma cruzi agmatinase, putative 0.008 0.0201 0.0683
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0183 0.0506 0.1298
Trichomonas vaginalis conserved hypothetical protein 0.0219 0.0615 0.0614
Echinococcus granulosus biogenic amine 5HT receptor 0.0022 0.003 0.0075
Trypanosoma brucei glucosidase, putative 0.0027 0.0043 0.0145
Schistosoma mansoni hypothetical protein 0.0022 0.003 0.0076
Loa Loa (eye worm) Smad1 0.002 0.0025 0.0084
Loa Loa (eye worm) hypothetical protein 0.017 0.0469 0.1598
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0069 0.0169 0.0268
Schistosoma mansoni neuropeptide receptor 0.0022 0.003 0.0076
Brugia malayi CXXC zinc finger family protein 0.0021 0.0026 0.009
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.1653 0.4867 1
Trichomonas vaginalis D-aminoacylase, putative 0.017 0.0469 0.0469
Echinococcus multilocularis ecdysone induced protein 78C 0.0183 0.0506 0.0805
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0.0012 0.004
Trypanosoma brucei inosine-5'-monophosphate dehydrogenase 0.1003 0.2937 1
Loa Loa (eye worm) hypothetical protein 0.0022 0.003 0.0101
Echinococcus granulosus lamin 0.0047 0.0104 0.0267
Brugia malayi beta-lactamase 0.017 0.0469 0.1598
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0183 0.0506 0.1299
Echinococcus multilocularis lysosomal alpha glucosidase 0.012 0.0319 0.0507
Brugia malayi jmjC domain containing protein 0.0069 0.0169 0.0574
Echinococcus granulosus tachykinin peptides receptor 99D 0.0022 0.003 0.0075
Loa Loa (eye worm) hypothetical protein 0.0022 0.003 0.0101
Schistosoma mansoni nuclear hormone receptor 0.0086 0.022 0.0564
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0022 0.003 0.0076
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0022 0.003 0.0047
Onchocerca volvulus 0.0026 0.004 0.0061
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0027 0.0043 0.0042
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.3385 1 1
Schistosoma mansoni tar DNA-binding protein 0.0104 0.0273 0.0699
Loa Loa (eye worm) neuropeptide F receptor 0.0022 0.003 0.0101
Mycobacterium leprae Probable inosine-5'-monophosphate dehydrogenase GuaB2 (IMP dehydrogenase) (IMPDH) (IMPD) 0.1003 0.2937 0.6026
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0183 0.0506 0.1724
Loa Loa (eye worm) hypothetical protein 0.017 0.0469 0.1598
Mycobacterium tuberculosis Possible penicillin-binding protein 0.1089 0.3193 0.6561
Brugia malayi Intermediate filament tail domain containing protein 0.0047 0.0104 0.0355
Loa Loa (eye worm) hypothetical protein 0.0086 0.022 0.0749
Loa Loa (eye worm) MH2 domain-containing protein 0.0301 0.0856 0.2914
Echinococcus multilocularis lamin dm0 0.0047 0.0104 0.0166
Mycobacterium tuberculosis Conserved protein 0.017 0.0469 0.0964
Echinococcus multilocularis neuropeptide receptor A26 0.0022 0.003 0.0047
Echinococcus granulosus 3'partial|arginase 2 mitochondrial 0.0219 0.0615 0.1575
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0086 0.022 0.0883
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0022 0.003 0.0101
Brugia malayi conserved hypotetical protein 0.0086 0.022 0.0749
Trypanosoma brucei DNA polymerase eta, putative 0.0039 0.008 0.0273
Loa Loa (eye worm) hypothetical protein 0.0022 0.003 0.0101
Loa Loa (eye worm) neuropeptide F receptor 0.0022 0.003 0.0101
Schistosoma mansoni TGF-beta signal transducer Smad2 0.002 0.0025 0.0063
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0057 0.0133 0.0452
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0022 0.003 0.0076
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.012 0.0319 0.1085
Brugia malayi hypothetical protein 0.0022 0.003 0.0101
Schistosoma mansoni cpg binding protein 0.0021 0.0026 0.0068
Trichomonas vaginalis Arginase, putative 0.0219 0.0615 0.0614
Brugia malayi Dopamine receptor protein 1 0.0022 0.003 0.0101
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0062 0.0147 0.0233
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0183 0.0506 0.1724
Brugia malayi latrophilin 2 splice variant baaae 0.0179 0.0493 0.168
Echinococcus granulosus jumonji domain containing protein 0.0029 0.0051 0.013
Mycobacterium tuberculosis Probable inosine-5'-monophosphate dehydrogenase GuaB2 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase 0.1003 0.2937 0.6035
Schistosoma mansoni jumonji/arid domain-containing protein 0.0027 0.0043 0.0111
Schistosoma mansoni tar DNA-binding protein 0.0104 0.0273 0.0699
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0022 0.003 0.0101
Echinococcus multilocularis dna polymerase kappa 0.0039 0.008 0.0127
Echinococcus granulosus Nuclear hormone receptor HR96 0.0086 0.022 0.0563
Onchocerca volvulus 0.017 0.0469 0.2021
Brugia malayi ImpB/MucB/SamB family protein 0.0039 0.008 0.0273
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0022 0.003 0.0076
Loa Loa (eye worm) MH1 domain-containing protein 0.002 0.0025 0.0084
Schistosoma mansoni retinoic acid receptor RXR 0.0183 0.0506 0.1299
Trypanosoma brucei GMP reductase 0.1003 0.2937 1
Leishmania major guanosine monophosphate reductase 0.1003 0.2937 1
Brugia malayi MH1 domain containing protein 0.002 0.0025 0.0084
Mycobacterium tuberculosis Probable oxidoreductase 0.0077 0.0191 0.0391
Loa Loa (eye worm) inositol-1 0.0077 0.0193 0.0659
Loa Loa (eye worm) hypothetical protein 0.0019 0.0021 0.007
Echinococcus granulosus PHD finger protein rhinoceros 0.0021 0.0026 0.0067
Trichomonas vaginalis CAMK family protein kinase 0.0134 0.0362 0.0362
Onchocerca volvulus 0.0022 0.003 0.0015
Leishmania major 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0021 0.0028 0.0094
Plasmodium vivax ataxin-2 like protein, putative 0.0021 0.0026 0.0089
Mycobacterium leprae Probable lipase LipE 0.017 0.0469 0.0943
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0022 0.003 0.0076
Schistosoma mansoni RAR-like nuclear receptor 0.0183 0.0506 0.1299
Echinococcus granulosus serotonin receptor 0.0022 0.003 0.0075
Loa Loa (eye worm) hypothetical protein 0.0022 0.003 0.0101
Plasmodium vivax acyl-CoA synthetase, putative 0.0019 0.0021 0.0071
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0183 0.0506 0.1724
Loa Loa (eye worm) hypothetical protein 0.0022 0.003 0.0101
Schistosoma mansoni ap endonuclease 0.0012 0 0.0001
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0077 0.0193 0.0193
Echinococcus granulosus peregrin 0.0021 0.0026 0.0067
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0022 0.003 0.0076
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0022 0.003 0.0076
Echinococcus multilocularis cpg binding protein 0.0022 0.003 0.0047
Onchocerca volvulus 0.0022 0.003 0.0015
Mycobacterium tuberculosis Conserved protein 0.017 0.0469 0.0964
Echinococcus multilocularis thyroid hormone receptor alpha 0.0183 0.0506 0.0805
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0022 0.003 0.0047
Echinococcus granulosus alpha 1A adrenergic receptor 0.0022 0.003 0.0075
Mycobacterium ulcerans inosine 5-monophosphate dehydrogenase 0.0446 0.1285 0.2641
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.017 0.0469 0.0964
Echinococcus multilocularis GPCR, family 2 0.0083 0.0209 0.0332
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0086 0.022 0.0564
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0126 0.0337 0.1148
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.008 0.0273
Loa Loa (eye worm) hypothetical protein 0.0083 0.0209 0.0712
Loa Loa (eye worm) jmjC domain-containing protein 0.0043 0.0093 0.0316
Brugia malayi F/Y-rich N-terminus family protein 0.0017 0.0014 0.0047
Echinococcus multilocularis neuropeptide Y receptor 0.0022 0.003 0.0047
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.008 0.0273
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0012 0 0.0001
Echinococcus multilocularis 0.0219 0.0615 0.0978
Schistosoma mansoni aldehyde dehydrogenase 0.0062 0.0147 0.0377
Echinococcus granulosus inosine 5' monophosphate dehydrogenase 2 0.1003 0.2937 0.7532
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0022 0.003 0.0101
Echinococcus multilocularis rhodopsin orphan GPCR 0.0022 0.003 0.0047
Echinococcus granulosus neuropeptide s receptor 0.0022 0.003 0.0075
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0266 0.0753 0.2562
Plasmodium falciparum phd finger protein, putative 0.0021 0.0026 0.009
Echinococcus granulosus mothers against decapentaplegic 5 0.002 0.0025 0.0063
Echinococcus granulosus histone lysine methyltransferase setb 0.0096 0.0249 0.0638
Brugia malayi Melatonin receptor type 1A 0.0022 0.003 0.0101
Brugia malayi GMP reductase 0.0441 0.1271 0.4329
Trypanosoma cruzi PAB1-binding protein , putative 0.0021 0.0026 0.0088
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0022 0.003 0.0047
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0077 0.0191 0.0391
Loa Loa (eye worm) hypothetical protein 0.0022 0.003 0.0101
Schistosoma mansoni lamin 0.0047 0.0104 0.0268
Entamoeba histolytica serine/threonine protein kinase, putative 0.0134 0.0362 0.0362
Schistosoma mansoni adenoreceptor 0.0022 0.003 0.0076
Loa Loa (eye worm) hypothetical protein 0.0022 0.003 0.0101
Giardia lamblia Kinase, PLK 0.0134 0.0362 0.0362
Plasmodium vivax glutathione reductase, putative 0.003 0.0053 0.0183
Brugia malayi inosine-5'-monophosphate dehydrogenase family protein 0.1003 0.2937 1
Brugia malayi neuropeptide F receptor 0.0022 0.003 0.0101
Loa Loa (eye worm) transcription factor SMAD2 0.0301 0.0856 0.2914
Entamoeba histolytica hypothetical protein 0.0016 0.0011 0.0011
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0183 0.0506 0.1724
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0173 0.0476 0.0757
Onchocerca volvulus 0.0022 0.003 0.0015
Loa Loa (eye worm) glutathione reductase 0.003 0.0053 0.0182
Schistosoma mansoni amine GPCR 0.0022 0.003 0.0076
Loa Loa (eye worm) thioredoxin reductase 0.003 0.0053 0.0182
Brugia malayi hypothetical protein 0.0013 0.0004 0.0014
Onchocerca volvulus Neuropeptide F receptor homolog 0.0022 0.003 0.0015
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0092 0.0237 0.0608
Schistosoma mansoni coup transcription factor 0.0183 0.0506 0.1299
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0183 0.0506 0.1299
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0097 0.0251 0.0398
Mycobacterium tuberculosis Probable citrate (pro-3S)-lyase (beta subunit) CitE (citrase) (citratase) (citritase) (citridesmolase) (citrase aldolase) 0.0021 0.0028 0.0056
Trypanosoma brucei DNA polymerase kappa, putative 0.0027 0.0044 0.015
Loa Loa (eye worm) hypothetical protein 0.0022 0.003 0.0101
Loa Loa (eye worm) hypothetical protein 0.0022 0.003 0.0101
Brugia malayi inosine-5'-monophosphate dehydrogenase 0.0441 0.1271 0.4329
Mycobacterium tuberculosis Conserved hypothetical protein 0.0039 0.008 0.0164
Schistosoma mansoni alpha glucosidase 0.0027 0.0043 0.0109
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.3385 1 1
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0134 0.0362 0.0576
Schistosoma mansoni hypothetical protein 0.0083 0.0209 0.0536
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0027 0.0043 0.0042
Schistosoma mansoni histamine h1 receptor 0.0022 0.003 0.0076
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0183 0.0506 0.1298
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0022 0.003 0.0015
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0096 0.0249 0.0396
Mycobacterium ulcerans esterase/lipase LipP 0.017 0.0469 0.0965
Echinococcus multilocularis geminin 0.1327 0.3899 0.6205
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0018 0.0035
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0016 0.0011 0.0039
Trichomonas vaginalis CAMK family protein kinase 0.0067 0.0161 0.0161
Brugia malayi Dopamine receptor 0.0022 0.003 0.0101
Mycobacterium tuberculosis Probable conserved lipoprotein 0.017 0.0469 0.0964
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0134 0.0362 0.1234
Plasmodium falciparum arginase 0.0219 0.0615 0.2103
Brugia malayi Calcitonin receptor-like protein seb-1 0.0261 0.0738 0.2514
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0022 0.003 0.0076
Echinococcus granulosus sex peptide receptor 0.0022 0.003 0.0075
Brugia malayi Glycosyl hydrolases family 31 protein 0.0027 0.0043 0.0145
Trichomonas vaginalis sucrase-isomaltase, putative 0.0027 0.0043 0.0042
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0022 0.003 0.0101
Loa Loa (eye worm) steroid hormone receptor 0.0183 0.0506 0.1724
Echinococcus multilocularis rhodopsin orphan GPCR 0.0022 0.003 0.0047
Trypanosoma cruzi hypothetical protein, conserved 0.017 0.0469 0.1598
Brugia malayi AMP-binding enzyme family protein 0.0026 0.004 0.0136
Leishmania major alpha glucosidase II subunit, putative 0.0027 0.0043 0.0145
Schistosoma mansoni nuclear hormone receptor 0.0086 0.022 0.0564
Trypanosoma brucei hypothetical protein, conserved 0.0016 0.0011 0.0039
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0183 0.0506 0.1724
Brugia malayi inosine-5'-monophosphate dehydrogenase 0.0441 0.1271 0.4329
Schistosoma mansoni nuclear receptor 0.0086 0.022 0.0564
Brugia malayi AMP-binding enzyme family protein 0.0026 0.004 0.0136
Loa Loa (eye worm) hypothetical protein 0.0019 0.0021 0.007
Trypanosoma brucei unspecified product 0.0039 0.008 0.0273
Loa Loa (eye worm) MH2 domain-containing protein 0.002 0.0025 0.0084
Onchocerca volvulus 0.0047 0.0104 0.0356
Loa Loa (eye worm) hypothetical protein 0.0047 0.0104 0.0355
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0183 0.0506 0.1724
Plasmodium falciparum thioredoxin reductase 0.003 0.0053 0.0183
Brugia malayi larval opioid receptor 0.0022 0.003 0.0101
Onchocerca volvulus 0.048 0.1387 0.6207
Echinococcus granulosus rhodopsin orphan GPCR 0.0022 0.003 0.0075
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.2131 0.6284 1
Schistosoma mansoni arginase 0.0219 0.0615 0.1576
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0022 0.003 0.0101
Echinococcus multilocularis arginase 2, mitochondrial 0.0219 0.0615 0.0978
Trichomonas vaginalis D-aminoacylase, putative 0.017 0.0469 0.0469
Trypanosoma cruzi hypothetical protein, conserved 0.017 0.0469 0.1598
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0266 0.0753 0.2562
Brugia malayi nuclear hormone receptor family member nhr-6 0.0086 0.022 0.0749
Loa Loa (eye worm) hypothetical protein 0.0022 0.003 0.0101
Brugia malayi hypothetical protein 0.0022 0.003 0.0101
Plasmodium vivax SET domain protein, putative 0.0096 0.0249 0.0853
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0022 0.003 0.0047
Onchocerca volvulus Serine\/threonine kinase homolog 0.0134 0.0362 0.1533
Echinococcus multilocularis neuropeptide receptor 0.0022 0.003 0.0047
Trichomonas vaginalis inositol monophosphatase, putative 0.0077 0.0193 0.0193
Echinococcus multilocularis lamin 0.0047 0.0104 0.0166
Schistosoma mansoni amine GPCR 0.0022 0.003 0.0076
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0039 0.008 0.0273
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0022 0.003 0.0076
Echinococcus granulosus peptide allatostatin:somatostatin 0.0022 0.003 0.0075
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0183 0.0506 0.1724
Brugia malayi Dopamine receptor protein 2 0.0022 0.003 0.0101
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0022 0.003 0.0047
Echinococcus granulosus dro:myosuppressin receptor 0.0022 0.003 0.0075
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0261 0.0738 0.2514
Loa Loa (eye worm) PHD-finger family protein 0.0021 0.0026 0.009
Echinococcus multilocularis mothers against decapentaplegic 5 0.002 0.0025 0.0039
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0022 0.003 0.0076
Plasmodium falciparum glutathione reductase 0.003 0.0053 0.0183
Echinococcus granulosus rhodopsin orphan GPCR 0.0022 0.003 0.0075
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0183 0.0506 0.1298
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0037 0.0075 0.0255
Echinococcus granulosus geminin 0.1327 0.3899 1
Brugia malayi G-protein coupled receptor 0.0022 0.003 0.0101
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0183 0.0506 0.1724
Mycobacterium ulcerans glutaminase 0.0278 0.0788 0.1619
Loa Loa (eye worm) latrophilin receptor protein 2 0.0083 0.0209 0.0712
Trichomonas vaginalis D-aminoacylase, putative 0.017 0.0469 0.0469
Echinococcus multilocularis PHD finger protein rhinoceros 0.0021 0.0026 0.0041
Wolbachia endosymbiont of Brugia malayi IMP dehydrogenase 0.1003 0.2937 1
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0012 0 0.0001
Brugia malayi Nuclear hormone receptor-like 1 0.0097 0.0251 0.0853
Trypanosoma cruzi trypanothione reductase, putative 0.003 0.0053 0.0182
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0057 0.0133 0.034
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.3385 1 1
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0069 0.0168 0.0323
Trichomonas vaginalis conserved hypothetical protein 0.0219 0.0615 0.0614
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.0147 0.0302
Mycobacterium tuberculosis Probable inosine-5'-monophosphate dehydrogenase GuaB3 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase 0.0557 0.1616 0.332
Brugia malayi MH2 domain containing protein 0.0301 0.0856 0.2914
Leishmania major hypothetical protein, conserved 0.0186 0.0516 0.1757
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0106 0.0278 0.0442
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0173 0.0476 0.122
Echinococcus multilocularis beta LACTamase domain containing family member 0.017 0.0469 0.0747
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.008 0.0273
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0183 0.0506 0.1724
Loa Loa (eye worm) hypothetical protein 0.0022 0.003 0.0101
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0021 0.0028 0.0094
Loa Loa (eye worm) hypothetical protein 0.0022 0.003 0.0101
Echinococcus multilocularis dna polymerase eta 0.0039 0.008 0.0127
Loa Loa (eye worm) hypothetical protein 0.0022 0.003 0.0101
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.017 0.0469 0.0964
Loa Loa (eye worm) hypothetical protein 0.0022 0.003 0.0101
Trypanosoma cruzi PAB1-binding protein , putative 0.0021 0.0026 0.0088
Echinococcus granulosus neuropeptide FF receptor 2 0.0022 0.003 0.0075
Brugia malayi hypothetical protein 0.0228 0.064 0.218
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0026 0.004 0.0058
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0023 0.0032 0.008
Leishmania major arginase 0.0219 0.0615 0.2093
Loa Loa (eye worm) hypothetical protein 0.0022 0.003 0.0101
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0022 0.003 0.0047
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0077 0.0193 0.0659
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0022 0.003 0.0047
Echinococcus granulosus g protein coupled receptor 0.0022 0.003 0.0075
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0047 0.0104 0.0355
Echinococcus granulosus tm gpcr rhodopsin 0.0022 0.003 0.0075
Brugia malayi MH2 domain containing protein 0.002 0.0025 0.0084
Trypanosoma cruzi DNA polymerase kappa, putative 0.0039 0.008 0.0273
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0183 0.0506 0.1724
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0183 0.0506 0.1724
Schistosoma mansoni amine GPCR 0.0022 0.003 0.0076
Mycobacterium tuberculosis Probable dehydrogenase 0.0069 0.0168 0.0345
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0026 0.004 0.0082
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0097 0.0251 0.0642
Schistosoma mansoni alpha-glucosidase 0.0103 0.0269 0.0691
Echinococcus granulosus ecdysone induced protein 78C 0.0183 0.0506 0.1298
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0022 0.003 0.0076
Leishmania major agmatinase-like protein 0.008 0.0201 0.0683
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0039 0.008 0.0164
Loa Loa (eye worm) hypothetical protein 0.0039 0.008 0.0273
Loa Loa (eye worm) CXXC zinc finger family protein 0.0021 0.0026 0.009
Onchocerca volvulus 0.0069 0.0169 0.0651
Loa Loa (eye worm) hypothetical protein 0.0183 0.0506 0.1724
Plasmodium falciparum acyl-CoA synthetase 0.0019 0.0021 0.0071
Mycobacterium tuberculosis Probable lipase LipE 0.017 0.0469 0.0964
Echinococcus multilocularis sex peptide receptor 0.0022 0.003 0.0047
Echinococcus granulosus arginase 2 mitochondrial 0.0219 0.0615 0.1575
Echinococcus multilocularis jumonji domain containing protein 0.0029 0.0051 0.008
Trichomonas vaginalis alpha-glucosidase, putative 0.0027 0.0043 0.0042
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0062 0.0147 0.0501
Onchocerca volvulus Putative GMP reductase 0.0441 0.1271 0.5681
Schistosoma mansoni inositol monophosphatase 0.0077 0.0193 0.0496
Mycobacterium ulcerans citrate lyase beta subunit, CitE_2 0.0021 0.0028 0.0057
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0086 0.022 0.0349
Brugia malayi Smad1 0.002 0.0025 0.0084
Echinococcus granulosus beta LACTamase domain containing family member 0.017 0.0469 0.1203
Toxoplasma gondii histone lysine methyltransferase SET1 0.0043 0.0093 0.0316
Onchocerca volvulus 0.0096 0.0249 0.1017
Loa Loa (eye worm) beta-lactamase 0.017 0.0469 0.1598
Leishmania major inosine-5-monophosphate dehydrogenase 0.1003 0.2937 1
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0016 0.0012 0.0018
Toxoplasma gondii PHD-finger domain-containing protein 0.0021 0.0026 0.009
Echinococcus multilocularis fmrfamide receptor 0.0022 0.003 0.0047
Toxoplasma gondii thioredoxin reductase 0.003 0.0053 0.0182
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0012 0.004
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0126 0.0337 0.1148
Trichomonas vaginalis CAMK family protein kinase 0.0134 0.0362 0.0362
Loa Loa (eye worm) hypothetical protein 0.0086 0.022 0.0749
Echinococcus granulosus FTZ F1 alpha 0.0183 0.0506 0.1298
Trypanosoma brucei polo-like protein kinase 0.0134 0.0362 0.1234
Loa Loa (eye worm) hypothetical protein 0.0228 0.064 0.218
Mycobacterium ulcerans hypothetical protein 0.0026 0.004 0.0082
Brugia malayi Steroid receptor seven-up type 2 0.0183 0.0506 0.1724
Echinococcus granulosus rhodopsin orphan GPCR 0.0022 0.003 0.0075
Brugia malayi nuclear receptor RXR 0.0097 0.0251 0.0853
Schistosoma mansoni kinase 0.0068 0.0166 0.0427
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0022 0.003 0.0101
Loa Loa (eye worm) hypothetical protein 0.0086 0.022 0.0749
Trichomonas vaginalis penicillin-binding protein, putative 0.017 0.0469 0.0469
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0016 0.0012 0.004
Brugia malayi RNA recognition motif domain containing protein 0.0104 0.0273 0.0928
Mycobacterium ulcerans hypothetical protein 0.017 0.0469 0.0965
Leishmania major phosphopantetheinyl transferase-like protein 0.0016 0.0011 0.0039
Loa Loa (eye worm) hypothetical protein 0.0022 0.003 0.0101
Loa Loa (eye worm) hypothetical protein 0.0261 0.0738 0.2514
Schistosoma mansoni cpg binding protein 0.0022 0.003 0.0077
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0022 0.003 0.0075
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0016 0.0012 0.0023
Mycobacterium ulcerans inosine 5-monophosphate dehydrogenase 0.0998 0.2923 0.6007
Loa Loa (eye worm) jmjC domain-containing protein 0.0027 0.0043 0.0147
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0012 0 0.0001
Mycobacterium leprae PROBABLE INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE GUAB1(IMP DEHYDROGENASE) (IMPDH) (IMPD) 0.0446 0.1285 0.2623
Loa Loa (eye worm) hypothetical protein 0.0022 0.003 0.0101
Trypanosoma cruzi hypothetical protein, conserved 0.0186 0.0516 0.1757
Echinococcus granulosus rhodopsin orphan GPCR 0.0022 0.003 0.0075
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0016 0.001 0.0027
Mycobacterium ulcerans beta-lactamase 0.017 0.0469 0.0965
Toxoplasma gondii hypothetical protein 0.0043 0.0091 0.031
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0023 0.0032 0.005
Loa Loa (eye worm) hypothetical protein 0.0022 0.003 0.0101
Brugia malayi Nuclear hormone receptor E75 0.0086 0.022 0.0749
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.008 0.0273
Brugia malayi nuclear hormone receptor 0.0086 0.022 0.0749
Schistosoma mansoni neuropeptide f receptor 76f 0.0022 0.003 0.0076
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0012 0.004
Schistosoma mansoni hypothetical protein 0.0179 0.0493 0.1265
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0016 0.0011 0.0038
Loa Loa (eye worm) GMP reductase 0.0441 0.1271 0.4329
Brugia malayi AMP-binding enzyme family protein 0.0026 0.004 0.0136
Echinococcus multilocularis g protein coupled receptor 0.0022 0.003 0.0047
Trichomonas vaginalis DNA polymerase eta, putative 0.0039 0.008 0.008
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0016 0.0012 0.004
Loa Loa (eye worm) hypothetical protein 0.0022 0.003 0.0101
Echinococcus granulosus citrate lyase subunit beta protein 0.0021 0.0028 0.007
Schistosoma mansoni glutaminase 0.0278 0.0788 0.2021
Leishmania major DNA polymerase eta, putative 0.0039 0.008 0.0273
Brugia malayi MH2 domain containing protein 0.002 0.0025 0.0084
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0077 0.0193 0.0658
Brugia malayi beta-lactamase family protein 0.017 0.0469 0.1598
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0022 0.003 0.0076
Brugia malayi steroid hormone receptor 0.0183 0.0506 0.1724
Plasmodium falciparum inosine-5'-monophosphate dehydrogenase 0.0998 0.2923 1
Schistosoma mansoni hypothetical protein 0.0021 0.0026 0.0068
Loa Loa (eye worm) hypothetical protein 0.017 0.0469 0.1598
Leishmania major DNA polymerase kappa, putative 0.0039 0.008 0.0273
Brugia malayi hypothetical protein 0.0097 0.0251 0.0853
Echinococcus granulosus thioredoxin glutathione reductase 0.003 0.0053 0.0136

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 5.1735 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) = 8.9125 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 11.6891 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 22.3872 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase). (Class of assay: confirmatory) [Related pubchem assays: 2429 (Confirmation qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2407 (Probe Development Summary for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2427 (Thermal Shift Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase))] ChEMBL. No reference
Potency (binding) 25.1189 uM PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 25.929 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 28.1838 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 29.0929 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) = 35.4813 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) 37.6858 uM PubChem BioAssay. qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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