Detailed information for compound 904089

Basic information

Technical information
  • TDR Targets ID: 904089
  • Name: 3-[(4-fluorophenyl)methylsulfanyl]-6-furan-2- ylpyridazine
  • MW: 286.324 | Formula: C15H11FN2OS
  • H donors: 0 H acceptors: 2 LogP: 3.05 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: Fc1ccc(cc1)CSc1ccc(nn1)c1ccco1
  • InChi: 1S/C15H11FN2OS/c16-12-5-3-11(4-6-12)10-20-15-8-7-13(17-18-15)14-2-1-9-19-14/h1-9H,10H2
  • InChiKey: FOUDUEZPNRBTAG-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

  • 3-[(4-fluorophenyl)methylsulfanyl]-6-(2-furyl)pyridazine
  • 3-[(4-fluorophenyl)methylthio]-6-(2-furyl)pyridazine
  • 3-[(4-fluorobenzyl)thio]-6-(2-furyl)pyridazine
  • 3-[(4-fluorophenyl)methylsulfanyl]-6-furan-2-yl-pyridazine
  • SMR000237143
  • ZINC04357716
  • MLS000696746

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens Werner syndrome, RecQ helicase-like Starlite/ChEMBL No references
Homo sapiens RAB9A, member RAS oncogene family Starlite/ChEMBL No references
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references
Homo sapiens breast cancer 1, early onset Starlite/ChEMBL No references
Homo sapiens tumor protein p53 Starlite/ChEMBL No references
Homo sapiens ATPase family, AAA domain containing 5 Starlite/ChEMBL No references
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references
Photinus pyralis Luciferin 4-monooxygenase Starlite/ChEMBL No references
Homo sapiens Niemann-Pick disease, type C1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Mycobacterium ulcerans long-chain fatty-acid CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) ATP-dependent DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium yoelii ATP-dependent DNA helicase recQ-related Get druggable targets OG5_126644 All targets in OG5_126644
Trichomonas vaginalis DNA helicase recq, putative Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni DNA helicase recq1 Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium yoelii peroxisomal-coenzyme a synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Cryptosporidium parvum RecQ bloom helicase (RNA helicase+hrdc) Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium vivax acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Theileria parva DNA helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum Bloom syndrome protein homolog, putative Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus ATP dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128206 All targets in OG5_128206
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Cryptosporidium hominis DEAD/DEAH box helicase Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium berghei acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Treponema pallidum ATP-dependent DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Giardia lamblia Sgs1 DNA helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Babesia bovis ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis ATP dependent DNA helicase Q5 Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Candida albicans DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis ATP dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium falciparum ADP-dependent DNA helicase RecQ Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium falciparum acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) RecQ helicase Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128206 All targets in OG5_128206
Plasmodium knowlesi ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Entamoeba histolytica recQ family DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Candida albicans potential membrane protein similar to S. cerevisiae NCR1 (YPL006W) and human NPC1 late endosomal protein involved in sterol home Get druggable targets OG5_128206 All targets in OG5_128206
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Neospora caninum hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni DNA helicase recq5 Get druggable targets OG5_126644 All targets in OG5_126644
Onchocerca volvulus Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma brucei gambiense ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica recQ family helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Neospora caninum hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium falciparum ATP-dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Entamoeba histolytica acyl-coA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis tumor protein p63 Get druggable targets OG5_140038 All targets in OG5_140038
Leishmania braziliensis 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum ko:K07003 Niemann Pick type C1, putative Get druggable targets OG5_128206 All targets in OG5_128206
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core Get druggable targets OG5_139225 All targets in OG5_139225
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum Niemann-Pick C1 protein precursor, putative Get druggable targets OG5_128206 All targets in OG5_128206
Schistosoma japonicum Niemann-Pick C1 protein precursor, putative Get druggable targets OG5_128206 All targets in OG5_128206
Echinococcus granulosus Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Plasmodium knowlesi ATP-dependent DNA helicase Q1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Theileria parva hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium yoelii ATP-dependent DNA helicase-related Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Entamoeba histolytica Niemann-Pick C1 protein, putative Get druggable targets OG5_128206 All targets in OG5_128206
Schistosoma mansoni niemann-pick C1 (NPC1) Get druggable targets OG5_128206 All targets in OG5_128206
Brugia malayi Niemann-Pick C1 protein precursor Get druggable targets OG5_128206 All targets in OG5_128206
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi Bloom's syndrome protein homolog Get druggable targets OG5_126644 All targets in OG5_126644
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Candida albicans DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Trichomonas vaginalis DNA helicase recq, putative Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Babesia bovis ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum ko:K03654 ATP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus tumor protein p63 Get druggable targets OG5_140038 All targets in OG5_140038
Leishmania braziliensis ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania donovani ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Trichomonas vaginalis DNA helicase recq1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium berghei ATP-dependent DNA helicase Q1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus bloom syndrome protein Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania mexicana ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium knowlesi acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis expressed conserved protein Get druggable targets OG5_128206 All targets in OG5_128206
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus ATP dependent DNA helicase Q5 Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium berghei ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis bloom syndrome protein Get druggable targets OG5_126644 All targets in OG5_126644
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus expressed conserved protein Get druggable targets OG5_128206 All targets in OG5_128206
Schistosoma mansoni blooms syndrome DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Get druggable targets OG5_126609 All targets in OG5_126609
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Toxoplasma gondii type I fatty acid synthase, putative Luciferin 4-monooxygenase   550 aa 514 aa 19.8 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 596 aa 21.1 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 480 aa 22.5 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD29 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 529 aa 22.3 %
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 509 aa 21.8 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 601 aa 22.5 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 476 aa 23.5 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 581 aa 21.2 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD25 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 475 aa 21.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Loa Loa (eye worm) AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 489 aa 23.3 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 526 aa 22.4 %
Candida albicans similar to S. cerevisiae FAA4 (YMR246W) long-chain fatty acid--CoA synthetase Luciferin 4-monooxygenase   550 aa 478 aa 23.4 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 501 aa 24.4 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF Luciferin 4-monooxygenase   550 aa 558 aa 20.1 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 482 aa 24.3 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Cryptosporidium parvum putative long chain fatty acyl CoA synthetase having a signal peptide Luciferin 4-monooxygenase   550 aa 472 aa 24.8 %
Cryptosporidium hominis acetyl-CoenzymeA synthetase (acetate--coa ligase) (acyl-activating enzyme) Luciferin 4-monooxygenase   550 aa 549 aa 22.6 %
Cryptosporidium parvum acetyl-coenzyme A synthetase Luciferin 4-monooxygenase   550 aa 545 aa 22.8 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.8 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD23 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 542 aa 23.8 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 497 aa 24.7 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE Luciferin 4-monooxygenase   550 aa 502 aa 22.5 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD11 Luciferin 4-monooxygenase   550 aa 498 aa 23.5 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD29 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 617 aa 22.2 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 462 aa 23.8 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 487 aa 23.8 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase Luciferin 4-monooxygenase   550 aa 536 aa 24.4 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 480 aa 25.2 %
Babesia bovis fatty acyl-CoA synthetase family protein Luciferin 4-monooxygenase   550 aa 461 aa 23.4 %
Trypanosoma brucei fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 22.9 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD28 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 504 aa 22.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 576 aa 19.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 507 aa 20.9 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD9 Luciferin 4-monooxygenase   550 aa 463 aa 21.8 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 22.6 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 603 aa 22.6 %
Schistosoma japonicum ko:K08745 solute carrier family 27 (fatty acid transporter), member 1, putative Luciferin 4-monooxygenase   550 aa 501 aa 24.6 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 505 aa 28.1 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 582 aa 22.3 %
Echinococcus granulosus long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD24 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 526 aa 21.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 21.7 %
Theileria parva long-chain fatty acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 507 aa 23.5 %
Mycobacterium leprae PROBABLE FATTY-ACID--CoA LIGASE FADD21 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 565 aa 22.8 %
Onchocerca volvulus Matrilysin homolog Luciferin 4-monooxygenase   550 aa 466 aa 24.2 %
Mycobacterium leprae Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 461 aa 22.3 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD28 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 484 aa 20.5 %
Toxoplasma gondii propionate-CoA ligase Luciferin 4-monooxygenase   550 aa 550 aa 21.1 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD26 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 560 aa 21.4 %
Neospora caninum acetyl-coenzyme a synthetase, putative Luciferin 4-monooxygenase   550 aa 549 aa 20.9 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 443 aa 26.4 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Cryptosporidium hominis acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 26.1 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 466 aa 27.3 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 24.7 %
Schistosoma mansoni FAA1 Long-chain-fatty-acid--CoA ligase 1 Luciferin 4-monooxygenase   550 aa 494 aa 26.3 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 493 aa 20.7 %
Mycobacterium leprae Probable long-chain-fatty-acid-CoA ligase FadD15 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 484 aa 23.3 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 459 aa 27.0 %
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 Luciferin 4-monooxygenase   550 aa 493 aa 22.1 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD32 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase). Also shown to have acyl-ACP ligase activity. Luciferin 4-monooxygenase   550 aa 487 aa 22.4 %
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 535 aa 23.2 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase, FadD11 Luciferin 4-monooxygenase   550 aa 492 aa 24.6 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 545 aa 24.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 463 aa 23.5 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 527 aa 25.0 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 484 aa 26.0 %
Entamoeba histolytica acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 446 aa 22.0 %
Dictyostelium discoideum acetyl-CoA ligase Luciferin 4-monooxygenase   550 aa 549 aa 22.2 %
Leishmania braziliensis long-chain-fatty-acid-CoA ligase, putative Luciferin 4-monooxygenase   550 aa 504 aa 25.6 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 494 aa 24.3 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 577 aa 22.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Babesia bovis long-chain acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 445 aa 21.8 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 544 aa 21.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Trichomonas vaginalis AMP dependent ligase, putative Luciferin 4-monooxygenase   550 aa 445 aa 26.1 %
Onchocerca volvulus Lysine-specific histone demethylase 1A homolog Luciferin 4-monooxygenase   550 aa 550 aa 22.5 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 531 aa 19.0 %
Leishmania mexicana acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 559 aa 20.6 %
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 509 aa 22.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Leishmania major long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 23.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 499 aa 19.2 %
Cryptosporidium parvum acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 25.7 %
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein Luciferin 4-monooxygenase   550 aa 476 aa 22.5 %
Mycobacterium ulcerans non-ribosomal peptide synthetase Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 492 aa 23.6 %
Mycobacterium tuberculosis Probable acyl-CoA ligase FadD31 (acyl-CoA synthetase) (acyl-CoA synthase) Luciferin 4-monooxygenase   550 aa 592 aa 20.4 %
Mycobacterium ulcerans putative fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 576 aa 20.8 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD34 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 537 aa 20.9 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD32 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 442 aa 23.5 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Plasmodium falciparum ras-related protein Rab-5B RAB9A, member RAS oncogene family 201 aa 165 aa 30.9 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 517 aa 24.8 %
Leishmania braziliensis long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 496 aa 22.8 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 24.4 %
Leishmania mexicana long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 483 aa 23.8 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 4, putative Luciferin 4-monooxygenase   550 aa 497 aa 23.7 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 476 aa 20.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 593 aa 22.1 %
Leishmania donovani long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Trypanosoma congolense fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 500 aa 22.4 %
Neospora caninum Short-chain dehydrogenase/reductase SDR, related Luciferin 4-monooxygenase   550 aa 518 aa 19.1 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 530 aa 23.8 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD21 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 586 aa 24.4 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 550 aa 20.9 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 452 aa 26.1 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 502 aa 24.9 %
Mycobacterium leprae FATTY-ACID-CoA LIGASE FADD26 (FATTY-ACID-COA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 533 aa 22.7 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 490 aa 23.3 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 524 aa 24.0 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Trypanosoma cruzi fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 495 aa 22.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 494 aa 23.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 478 aa 21.1 %
Leishmania infantum long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 480 aa 21.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 558 aa 20.4 %
Echinococcus multilocularis long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 466 aa 21.7 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 497 aa 19.3 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0062 0.058 0.264
Loa Loa (eye worm) hypothetical protein 0.0012 0.0059 0.0256
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.0012 0.0059 0.0817
Brugia malayi Patched family protein 0.0007 0.0011 0.0036
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0059 0.0817
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0012 0.006 0.0082
Echinococcus multilocularis replication factor c subunit 1 0.0012 0.0059 0.0056
Loa Loa (eye worm) hypothetical protein 0.0007 0.0011 0.0036
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0021 0.0157 1
Brugia malayi DKFZp564C0469 protein 0.0012 0.0059 0.0256
Loa Loa (eye worm) hypothetical protein 0.0007 0.0011 0.0036
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.002 0.0139 0.8737
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0232 0.1045
Loa Loa (eye worm) hypothetical protein 0.0012 0.0063 0.0271
Loa Loa (eye worm) hypothetical protein 0.0029 0.0232 0.1045
Brugia malayi hypothetical protein 0.0007 0.0011 0.0036
Loa Loa (eye worm) hypothetical protein 0.0012 0.0063 0.0271
Loa Loa (eye worm) hypothetical protein 0.0012 0.0063 0.0271
Echinococcus multilocularis protein pangolin J 0.0146 0.144 0.1437
Toxoplasma gondii patched family protein 0.0007 0.0011 0.0837
Schistosoma mansoni topbp1 0.0012 0.0059 0.011
Loa Loa (eye worm) hypothetical protein 0.0007 0.0011 0.0036
Brugia malayi topoisomerase 0.0012 0.0059 0.0256
Echinococcus granulosus beta catenin 0.0219 0.2186 0.3164
Brugia malayi hypothetical protein 0.0007 0.0011 0.0036
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0029 0.0232 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0063 0.0271
Brugia malayi Patched family protein 0.0007 0.0011 0.0036
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0008 0.0024 0.1738
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0008 0.0024 0.0546
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0063 0.0059
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0012 0.0063 0.0271
Schistosoma mansoni coup transcription factor 0.0012 0.0063 0.0116
Loa Loa (eye worm) hypothetical protein 0.0012 0.0059 0.0256
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.0012 0.0059 0.0817
Schistosoma mansoni cellular tumor antigen P53 0.006 0.0551 0.1018
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0059 0.0817
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0029 0.0232 1
Brugia malayi AMP-binding enzyme family protein 0.0008 0.0024 0.0092
Loa Loa (eye worm) hypothetical protein 0.0007 0.0011 0.0036
Loa Loa (eye worm) hypothetical protein 0.0008 0.0024 0.0092
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0012 0.006 0.026
Brugia malayi Patched related family protein 10 0.0007 0.0011 0.0036
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0008 0.0024 0.0546
Loa Loa (eye worm) hypothetical protein 0.0012 0.0059 0.0256
Entamoeba histolytica recQ family helicase, putative 0.0015 0.0096 0.0832
Trypanosoma brucei BRCA1 C Terminus (BRCT) domain containing protein, putative 0.0012 0.0059 0.4918
Loa Loa (eye worm) hypothetical protein 0.0007 0.0011 0.0036
Onchocerca volvulus 0.0008 0.0024 0.0057
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0012 0.006 0.0057
Loa Loa (eye worm) hypothetical protein 0.0007 0.0011 0.0036
Onchocerca volvulus 0.0012 0.0063 0.0238
Toxoplasma gondii patched family protein 0.0007 0.0011 0.0837
Schistosoma mansoni RAR-like nuclear receptor 0.0012 0.0063 0.0116
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0012 0.0063 0.0116
Mycobacterium ulcerans NAD-dependent DNA ligase LigA 0.0012 0.0059 0.1722
Trypanosoma cruzi hypothetical protein, conserved 0.0012 0.0059 0.4918
Wolbachia endosymbiont of Brugia malayi NAD-dependent DNA ligase, Lig 0.0012 0.0059 0.5
Loa Loa (eye worm) hypothetical protein 0.0007 0.0011 0.0036
Brugia malayi Patched family protein 0.0007 0.0011 0.0036
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0008 0.0024 0.002
Echinococcus multilocularis ecdysone induced protein 78C 0.0012 0.0063 0.0059
Entamoeba histolytica hypothetical protein 0.0043 0.0384 0.3311
Brugia malayi Patched family protein 0.0007 0.0011 0.0036
Mycobacterium ulcerans hypothetical protein 0.0029 0.0232 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0059 0.0256
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0008 0.0024 0.0546
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0012 0.0063 0.0271
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0029 0.0232 1
Schistosoma mansoni hypothetical protein 0.0049 0.0443 0.0818
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0232 1
Loa Loa (eye worm) hypothetical protein 0.0007 0.0011 0.0036
Schistosoma mansoni nuclear hormone receptor 0.0012 0.0063 0.0116
Loa Loa (eye worm) hypothetical protein 0.0007 0.0011 0.0036
Toxoplasma gondii patched family protein 0.0007 0.0011 0.0837
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0012 0.0063 0.0059
Loa Loa (eye worm) patched family protein 0.0007 0.0011 0.0036
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0012 0.0063 0.0271
Echinococcus multilocularis bloom syndrome protein 0.0029 0.0235 0.0232
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0145 0.6071
Echinococcus granulosus Protein patched homolog 1 0.0051 0.0462 0.0664
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0012 0.0063 0.0059
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0063 0.0086
Loa Loa (eye worm) hypothetical protein 0.0007 0.0011 0.0036
Brugia malayi Niemann-Pick C1 protein precursor 0.0119 0.1159 0.5295
Onchocerca volvulus 0.0012 0.0059 0.0223
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0232 1
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0008 0.0024 0.0029
Loa Loa (eye worm) hypothetical protein 0.0008 0.0024 0.0092
Echinococcus granulosus nibrin 0.0012 0.0059 0.0081
Echinococcus multilocularis Niemann Pick C1 protein 0.017 0.1683 0.168
Schistosoma mansoni hypothetical protein 0.0043 0.0384 0.0709
Loa Loa (eye worm) hypothetical protein 0.0007 0.0011 0.0036
Echinococcus multilocularis sterol regulatory element binding protein 0.0051 0.0462 0.0458
Trichomonas vaginalis DNA helicase recq1, putative 0.0029 0.0235 0.483
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0029 0.0232 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0063 0.0271
Brugia malayi ecdysteroid receptor 0.0012 0.0063 0.0271
Echinococcus multilocularis nibrin 0.0012 0.0059 0.0056
Schistosoma mansoni blooms syndrome DNA helicase 0.0023 0.0173 0.0319
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0012 0.0063 0.0271
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0012 0.0063 0.0086
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0008 0.0024 0.0546
Brugia malayi Patched family protein 0.0007 0.0011 0.0036
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0232 1
Schistosoma mansoni retinoic acid receptor RXR 0.0012 0.0063 0.0116
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0063 0.0271
Brugia malayi AMP-binding enzyme family protein 0.0008 0.0024 0.0092
Entamoeba histolytica hypothetical protein 0.0043 0.0384 0.3311
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0008 0.0024 0.1738
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0012 0.0063 0.0271
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.0384 0.0709
Schistosoma mansoni hypothetical protein 0.0049 0.0443 0.0818
Loa Loa (eye worm) hypothetical protein 0.0007 0.0011 0.0036
Onchocerca volvulus 0.0008 0.0024 0.0057
Onchocerca volvulus 0.006 0.0551 0.2499
Loa Loa (eye worm) steroid hormone receptor 0.0012 0.0063 0.0271
Loa Loa (eye worm) hypothetical protein 0.0012 0.0063 0.0271
Loa Loa (eye worm) hypothetical protein 0.0012 0.0063 0.0271
Entamoeba histolytica acyl-CoA synthetase, putative 0.0029 0.0232 0.1998
Loa Loa (eye worm) patched family protein 0.0007 0.0011 0.0036
Loa Loa (eye worm) hypothetical protein 0.0119 0.1159 0.5295
Brugia malayi Patched family protein 0.0007 0.0011 0.0036
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0029 0.0232 1
Echinococcus granulosus expressed conserved protein 0.0112 0.1085 0.1568
Onchocerca volvulus 0.0008 0.0024 0.0057
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0008 0.0024 0.0092
Echinococcus granulosus pangolin 0.0146 0.144 0.2083
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0012 0.0063 0.0059
Brugia malayi photoreceptor-specific nuclear receptor 0.0012 0.0063 0.0271
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0008 0.0024 0.0546
Echinococcus granulosus bloom syndrome protein 0.0029 0.0235 0.0336
Brugia malayi Patched family protein 0.0007 0.0011 0.0036
Echinococcus granulosus sterol regulatory element binding protein 0.0051 0.0462 0.0664
Loa Loa (eye worm) hypothetical protein 0.0007 0.0011 0.0036
Brugia malayi Patched family protein 0.0007 0.0011 0.0036
Loa Loa (eye worm) hypothetical protein 0.0007 0.0011 0.0036
Brugia malayi Patched family protein 0.0007 0.0011 0.0036
Brugia malayi Steroid receptor seven-up type 2 0.0012 0.0063 0.0271
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0012 0.006 0.0057
Brugia malayi protein C24B5.3 0.0007 0.0011 0.0036
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0008 0.0024 0.0546
Brugia malayi nuclear hormone receptor 0.0012 0.0063 0.0271
Echinococcus granulosus Niemann Pick C1 protein 0.0119 0.1159 0.1675
Brugia malayi hypothetical protein 0.0012 0.0059 0.0256
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0012 0.0063 0.0271
Loa Loa (eye worm) RecQ helicase 0.0029 0.0235 0.1061
Trypanosoma cruzi BRCA1 C Terminus (BRCT) domain containing protein, putative 0.0012 0.0059 0.4918
Giardia lamblia Sgs1 DNA helicase, putative 0.0012 0.006 1
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0015 0.0096 1
Loa Loa (eye worm) hypothetical protein 0.0007 0.0011 0.0036
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0119 0.1159 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0145 0.6071
Loa Loa (eye worm) hypothetical protein 0.0007 0.0011 0.0036
Brugia malayi HMG box family protein 0.0146 0.144 0.6584
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0008 0.0024 0.0092
Loa Loa (eye worm) hypothetical protein 0.0029 0.0232 0.1045
Loa Loa (eye worm) hypothetical protein 0.0007 0.0011 0.0036
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0012 0.0063 0.0271
Loa Loa (eye worm) hypothetical protein 0.0029 0.0232 0.1045
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0063 0.0059
Loa Loa (eye worm) hypothetical protein 0.0007 0.0011 0.0036
Schistosoma mansoni patched 1 0.0051 0.0462 0.0853
Plasmodium falciparum replication factor C subunit 1, putative 0.0012 0.0059 0.2563
Echinococcus multilocularis tumor protein p63 0.0408 0.413 0.4128
Echinococcus granulosus ecdysone induced protein 78C 0.0012 0.0063 0.0086
Loa Loa (eye worm) hypothetical protein 0.0007 0.0011 0.0036
Loa Loa (eye worm) HMP-2 protein 0.0219 0.2186 1
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0012 0.006 0.0082
Brugia malayi Patched family protein 0.0007 0.0011 0.0036
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.0012 0.0059 0.0513
Onchocerca volvulus Cirhin homolog 0.0217 0.2171 1
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0232 0.1045
Brugia malayi hypothetical protein 0.0007 0.0011 0.0036
Loa Loa (eye worm) hypothetical protein 0.0021 0.0157 0.0704
Brugia malayi nuclear receptor NHR-88 0.0012 0.0063 0.0271
Entamoeba histolytica acyl-coA synthetase, putative 0.0029 0.0232 0.1998
Schistosoma mansoni DNA ligase IV 0.0012 0.0059 0.011
Echinococcus granulosus Niemann Pick C1 protein 0.017 0.1683 0.2436
Loa Loa (eye worm) hypothetical protein 0.006 0.0551 0.2509
Schistosoma mansoni hypothetical protein 0.0049 0.0443 0.0818
Brugia malayi Patched family protein 0.0007 0.0011 0.0036
Loa Loa (eye worm) patched family protein 0.0007 0.0011 0.0036
Loa Loa (eye worm) hypothetical protein 0.0012 0.006 0.026
Plasmodium vivax acyl-CoA synthetase, putative 0.0021 0.0157 1
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0021 0.0157 0.6617
Echinococcus multilocularis FTZ F1 alpha 0.0012 0.0063 0.0059
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0012 0.0063 0.0238
Toxoplasma gondii propionate-CoA ligase 0.0008 0.0024 0.1738
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0012 0.0063 0.0271
Echinococcus granulosus tumor protein p63 0.0408 0.413 0.5984
Brugia malayi Patched related family protein 4 0.0007 0.0011 0.0036
Echinococcus multilocularis protein dispatched 1 0.0058 0.0536 0.0532
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0029 0.0232 1
Loa Loa (eye worm) hypothetical protein 0.0007 0.0011 0.0036
Schistosoma mansoni acetyl-CoA synthetase 0.0008 0.0024 0.0044
Brugia malayi AMP-binding enzyme family protein 0.0008 0.0024 0.0092
Loa Loa (eye worm) hypothetical protein 0.0051 0.0462 0.2099
Brugia malayi Patched family protein 0.0007 0.0011 0.0036
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.0384 0.038
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0012 0.0063 0.0086
Loa Loa (eye worm) hypothetical protein 0.0007 0.0011 0.0036
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0012 0.0063 0.0116
Loa Loa (eye worm) hypothetical protein 0.0007 0.0011 0.0036
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0063 0.0271
Schistosoma mansoni DNA helicase recq5 0.0012 0.006 0.0111
Brugia malayi Myosin head containing protein 0.0007 0.0011 0.0036
Loa Loa (eye worm) hypothetical protein 0.0021 0.0157 0.0704
Plasmodium falciparum acyl-CoA synthetase 0.0021 0.0157 0.7768
Brugia malayi Patched family protein 0.0007 0.0011 0.0036
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0059 0.0817
Loa Loa (eye worm) hypothetical protein 0.0007 0.0011 0.0036
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0232 0.1045
Brugia malayi Patched protein homolog 1 0.0007 0.0011 0.0036
Onchocerca volvulus Bile acid receptor homolog 0.0012 0.0063 0.0238
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0012 0.0063 0.0059
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0145 0.6071
Loa Loa (eye worm) hypothetical protein 0.0007 0.0011 0.0036
Schistosoma mansoni pangolin 0.0146 0.144 0.2662
Loa Loa (eye worm) hypothetical protein 0.0012 0.0063 0.0271
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0008 0.0024 0.0546
Schistosoma mansoni hypothetical protein 0.0049 0.0443 0.0818
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0145 0.6071
Echinococcus multilocularis thyroid hormone receptor alpha 0.0012 0.0063 0.0059
Loa Loa (eye worm) HMG box family protein 0.0146 0.144 0.6584
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0015 0.0096 0.3501
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0008 0.0024 0.0092
Brugia malayi hypothetical protein 0.0043 0.0384 0.1742
Brugia malayi Bloom's syndrome protein homolog 0.0029 0.0235 0.1061
Brugia malayi Pax transcription activation domain interacting protein 0.0012 0.0059 0.0256
Loa Loa (eye worm) patched family protein 0.0007 0.0011 0.0036
Brugia malayi hypothetical protein 0.0012 0.0059 0.0256
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0012 0.0063 0.0116
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0012 0.006 0.026
Brugia malayi Patched family protein 0.0007 0.0011 0.0036
Schistosoma mansoni chromosome transmission fidelity factor 0.0012 0.0059 0.011
Echinococcus granulosus T cell transcription factor 4 long C terminal 0.0146 0.144 0.2083
Schistosoma mansoni beta-catenin 0.0219 0.2186 0.404
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0006 0.0004 0.0007
Loa Loa (eye worm) hypothetical protein 0.0007 0.0011 0.0036
Echinococcus granulosus replication factor c subunit 1 0.0012 0.0059 0.0081
Loa Loa (eye worm) hypothetical protein 0.0021 0.0157 0.0704
Onchocerca volvulus 0.0029 0.0232 0.1019
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0012 0.006 0.4422
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0012 0.0063 0.0271
Entamoeba histolytica hypothetical protein 0.0043 0.0384 0.3311
Schistosoma mansoni hypothetical protein 0.0533 0.5411 1
Loa Loa (eye worm) patched family protein 0.0007 0.0011 0.0036
Brugia malayi AMP-binding enzyme family protein 0.0008 0.0024 0.0092
Plasmodium vivax acetyl-CoA synthetase, putative 0.0008 0.0024 0.0844
Entamoeba histolytica acyl-CoA synthetase, putative 0.0029 0.0232 0.1998
Loa Loa (eye worm) hypothetical protein 0.0007 0.0011 0.0036
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0051 0.0462 0.2099
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0015 0.0096 1
Loa Loa (eye worm) hypothetical protein 0.0146 0.1437 0.6568
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0012 0.0059 0.0817
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0012 0.006 0.4422
Schistosoma mansoni thyroid hormone receptor 0.0012 0.0063 0.0116
Toxoplasma gondii patched family protein 0.0007 0.0011 0.0837
Echinococcus multilocularis protein patched 0.0051 0.0462 0.0458
Brugia malayi Patched family protein 0.0007 0.0011 0.0036
Brugia malayi hypothetical protein 0.0007 0.0011 0.0036
Trypanosoma cruzi hypothetical protein, conserved 0.0012 0.0059 0.4918
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0012 0.0063 0.0271
Mycobacterium leprae PROBABLE DNA LIGASE [NAD DEPENDENT] LIGA (POLYDEOXYRIBONUCLEOTIDE SYNTHASE [NAD+]) 0.0012 0.0059 0.1722
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.0012 0.0059 0.4363
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0012 0.0059 0.0817
Trichomonas vaginalis DNA helicase recq, putative 0.0029 0.0235 0.483
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0021 0.0157 0.6421
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0232 1
Echinococcus multilocularis beta catenin 0.0219 0.2186 0.2183
Echinococcus multilocularis T cell transcription factor 4 long C terminal 0.0146 0.144 0.1437
Loa Loa (eye worm) hypothetical protein 0.0021 0.0157 0.0704
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.0012 0.0059 0.0256
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0063 0.0271
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0012 0.0063 0.0271
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0029 0.0232 1
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0121 0.1178 0.2177
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0012 0.0063 0.0086
Onchocerca volvulus 0.0008 0.0024 0.0057
Trypanosoma cruzi FHA domain containing protein, putative 0.0012 0.0059 0.4918
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0012 0.006 0.2605
Schistosoma mansoni steroid hormone receptor ad4bp 0.0012 0.0063 0.0116
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0008 0.0024 0.0546
Loa Loa (eye worm) hypothetical protein 0.0007 0.0011 0.0036
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0012 0.0063 0.0271
Loa Loa (eye worm) hypothetical protein 0.0021 0.0157 0.0704
Loa Loa (eye worm) hypothetical protein 0.0007 0.0011 0.0036
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0029 0.0232 1
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0008 0.0024 0.0546
Loa Loa (eye worm) hypothetical protein 0.0012 0.0059 0.0256
Brugia malayi CHE-14 protein 0.0051 0.0462 0.2099
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0232 1
Plasmodium vivax replication factor C subunit 1, putative 0.0012 0.0059 0.3299
Entamoeba histolytica hypothetical protein 0.0012 0.0059 0.0513
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0012 0.0063 0.0271
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0063 0.0271
Trichomonas vaginalis replication factor C large subunit, putative 0.0012 0.0059 0.0817
Echinococcus granulosus FTZ F1 alpha 0.0012 0.0063 0.0086
Toxoplasma gondii hypothetical protein 0.0007 0.0011 0.0837
Echinococcus multilocularis expressed conserved protein 0.0112 0.1085 0.1082
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0059 0.0817
Loa Loa (eye worm) hypothetical protein 0.0007 0.0011 0.0036
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0024 0.0092
Loa Loa (eye worm) oxidoreductase 0.0008 0.0024 0.0092
Brugia malayi Armadillo/beta-catenin-like repeat family protein 0.0219 0.2186 1
Trichomonas vaginalis conserved hypothetical protein 0.0051 0.0462 1
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0025 0.0199 1
Schistosoma mansoni thyroid hormone receptor 0.0012 0.0063 0.0116
Brugia malayi protein C24B5.3 0.0007 0.0011 0.0036
Trichomonas vaginalis DNA helicase recq, putative 0.0015 0.0096 0.1662
Loa Loa (eye worm) hypothetical protein 0.0007 0.0011 0.0036
Brugia malayi steroid hormone receptor 0.0012 0.0063 0.0271
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0008 0.0024 0.0205
Brugia malayi Patched related family protein 12 0.0007 0.0011 0.0036
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0063 0.0271
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0012 0.0063 0.0116
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0006 0.0004 0.0007
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0012 0.0063 0.0116
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0012 0.0063 0.0086
Loa Loa (eye worm) hypothetical protein 0.0007 0.0011 0.0036
Brugia malayi Nuclear hormone receptor-like 1 0.0012 0.0063 0.0271
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0012 0.006 0.026
Schistosoma mansoni DNA helicase recq1 0.0012 0.006 0.0111
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0012 0.0063 0.0086
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0008 0.0024 0.0546
Loa Loa (eye worm) hypothetical protein 0.0012 0.0063 0.0271
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0019 0.0136 1
Treponema pallidum DNA ligase (lig) 0.0012 0.0059 0.5
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0008 0.0024 0.0546
Echinococcus multilocularis Niemann Pick C1 protein 0.0119 0.1159 0.1156
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0008 0.0024 0.0655
Loa Loa (eye worm) hypothetical protein 0.0007 0.0011 0.0036
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0059 0.0817
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0012 0.0063 0.0116
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.0384 0.0551
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0232 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0063 0.0086
Onchocerca volvulus Protein ultraspiracle homolog 0.0012 0.0063 0.0238
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0012 0.0063 0.0271
Toxoplasma gondii ATPase, AAA family protein 0.0012 0.0059 0.4363
Entamoeba histolytica hypothetical protein 0.0043 0.0384 0.3311
Echinococcus granulosus hypothetical protein 0.0678 0.69 1
Schistosoma mansoni topbp1 0.0012 0.0059 0.011
Loa Loa (eye worm) hypothetical protein 0.0012 0.0059 0.0256

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 3.1623 um PUBCHEM_BIOASSAY: qHTS Assay for Rab9 Promoter Activators. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 3.1623 um PUBCHEM_BIOASSAY: qHTS Assay for NPC1 Promoter Activators. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 4.7755 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (functional) = 6.3096 um PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 6.5131 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 7.0795 uM PubChem BioAssay. qHTS Assay to Identify Small Molecule Activators of BRCA1 Expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 7.3753 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 8.9125 uM PUBCHEM_BIOASSAY: qHTS assay for re-activators of p53 using a Luc reporter. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504709] ChEMBL. No reference
Potency (functional) 9.2 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that induce genotoxicity in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493106, AID493143] ChEMBL. No reference
Potency (functional) 10 uM PubChem BioAssay. qHTS for Inhibitors of WRN Helicase. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 10.4179 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 16.3601 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) = 22.3872 um PUBCHEM_BIOASSAY: qHTS Assay for Enhancers of SMN2 Splice Variant Expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) = 44.6684 um PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins. (Class of assay: confirmatory) [Related pubchem assays: 1011 (Confirmation Concentration-Response Assay for Inhibitors of the Schistosoma mansoni Redox Cascade ), 448 (Schistosoma Mansoni Peroxiredoxins (Prx2) and thioredoxin glutathione reductase (TGR) coupled assay)] ChEMBL. No reference
Potency (functional) = 50.1187 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 50.1187 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] ChEMBL. No reference
Potency (functional) 125.8925 uM PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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