Detailed information for compound 906419

Basic information

Technical information
  • TDR Targets ID: 906419
  • Name: N-[2-(1,3-benzodioxol-5-yl)-2-(4-phenylpipera zin-1-yl)ethyl]-3,3-dimethylbutanamide
  • MW: 423.548 | Formula: C25H33N3O3
  • H donors: 1 H acceptors: 1 LogP: 4.17 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(CC(C)(C)C)NCC(c1ccc2c(c1)OCO2)N1CCN(CC1)c1ccccc1
  • InChi: 1S/C25H33N3O3/c1-25(2,3)16-24(29)26-17-21(19-9-10-22-23(15-19)31-18-30-22)28-13-11-27(12-14-28)20-7-5-4-6-8-20/h4-10,15,21H,11-14,16-18H2,1-3H3,(H,26,29)
  • InChiKey: ZDFWYKDCEILIDM-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[2-(1,3-benzodioxol-5-yl)-2-(4-phenylpiperazin-1-yl)ethyl]-3,3-dimethyl-butanamide
  • N-[2-(1,3-benzodioxol-5-yl)-2-(4-phenyl-1-piperazinyl)ethyl]-3,3-dimethylbutanamide
  • N-[2-(1,3-benzodioxol-5-yl)-2-(4-phenylpiperazin-1-yl)ethyl]-3,3-dimethyl-butyramide
  • G856-4220
  • NCGC00135968-01

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens tumor protein p53 Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis tumor protein p63 Get druggable targets OG5_140038 All targets in OG5_140038
Echinococcus granulosus tumor protein p63 Get druggable targets OG5_140038 All targets in OG5_140038
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) oxidoreductase 0.0012 0.003 0.0094
Loa Loa (eye worm) dehydrogenase 0.0012 0.003 0.0094
Loa Loa (eye worm) dihydropteridine reductase-PC 0.0239 0.3081 1
Brugia malayi MH1 domain containing protein 0.001 0.0007 0.0023
Leishmania major quinonoid dihydropteridine reductase 0.025 0.3237 1
Schistosoma mansoni carbonyl reductase 0.0012 0.003 0.0024
Schistosoma mansoni short chain dehydrogenase 0.0012 0.003 0.0024
Echinococcus granulosus retinol dehydrogenase 11 0.0012 0.003 0.0029
Echinococcus granulosus carbonyl reductase 1 0.0012 0.003 0.0029
Toxoplasma gondii 6,7-dihydropteridine reductase 0.0239 0.3081 1
Brugia malayi Latrophilin receptor protein 2 0.0019 0.0131 0.0425
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0019 0.0131 0.0129
Brugia malayi hypothetical protein 0.0016 0.009 0.0293
Echinococcus granulosus hypothetical protein 0.0012 0.003 0.0029
Toxoplasma gondii exonuclease III APE 0.004 0.0406 0.1231
Schistosoma mansoni steroid dehydrogenase 0.0012 0.003 0.0024
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0012 0.003 0.0099
Loa Loa (eye worm) Smad1 0.001 0.0007 0.0017
Loa Loa (eye worm) hypothetical protein 0.0019 0.0131 0.042
Loa Loa (eye worm) MH1 domain-containing protein 0.001 0.0007 0.0017
Brugia malayi CXXC zinc finger family protein 0.003 0.0284 0.0923
Schistosoma mansoni 3-keto-dihydrosphingosine reductase 0.0012 0.003 0.0024
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.004 0.0406 1
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0012 0.003 0.0099
Schistosoma mansoni steroid dehydrogenase 0.0012 0.003 0.0024
Schistosoma mansoni hypothetical protein 0.0019 0.0131 0.0124
Schistosoma mansoni short chain dehydrogenase 0.0012 0.003 0.0024
Schistosoma mansoni steroid dehydrogenase 0.0012 0.003 0.0024
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0095 0.1152 0.3737
Schistosoma mansoni carbonyl reductase 0.0012 0.003 0.0024
Mycobacterium leprae PROBABLE SHORT CHAIN ALCOHOL DEHYDROGENASE/REDUCTASE 0.0012 0.003 0.5
Schistosoma mansoni short chain dehydrogenase 0.0012 0.003 0.0024
Brugia malayi hypothetical protein 0.0112 0.1376 0.4465
Loa Loa (eye worm) hypothetical protein 0.0012 0.003 0.0094
Loa Loa (eye worm) oxidoreductase 0.0012 0.003 0.0094
Loa Loa (eye worm) hypothetical protein 0.0012 0.003 0.0094
Brugia malayi Dehydrogenases, short chain protein 2 0.0012 0.003 0.0099
Toxoplasma gondii histone lysine methyltransferase SET1 0.0058 0.065 0.2032
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0012 0.003 0.0099
Loa Loa (eye worm) hypothetical protein 0.0012 0.003 0.0094
Echinococcus multilocularis TGF beta signal transducer SmadC 0.001 0.0007 0.0005
Schistosoma mansoni microtubule-associated protein tau 0.0754 1 1
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0012 0.003 0.0099
Schistosoma mansoni short chain dehydrogenase 0.0012 0.003 0.0024
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.004 0.0406 1
Echinococcus granulosus hypothetical protein 0.0012 0.003 0.0029
Schistosoma mansoni short chain dehydrogenase 0.0012 0.003 0.0024
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.0428 0.1389
Schistosoma mansoni steroid dehydrogenase 0.0012 0.003 0.0024
Schistosoma mansoni short chain dehydrogenase 0.0012 0.003 0.0024
Loa Loa (eye worm) latrophilin receptor protein 2 0.0019 0.0131 0.042
Leishmania major quinonoid dihydropteridine reductase 0.025 0.3237 1
Schistosoma mansoni steroid dehydrogenase 0.0012 0.003 0.0024
Schistosoma mansoni short chain dehydrogenase 0.0012 0.003 0.0024
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0012 0.003 0.0099
Schistosoma mansoni ap endonuclease 0.004 0.0406 0.0399
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.004 0.0406 0.1172
Schistosoma mansoni short chain dehydrogenase 0.0012 0.003 0.0024
Trichomonas vaginalis ap endonuclease, putative 0.004 0.0406 1
Brugia malayi MH2 domain containing protein 0.001 0.0007 0.0023
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0209 0.0556
Schistosoma mansoni short chain dehydrogenase 0.0012 0.003 0.0024
Loa Loa (eye worm) hypothetical protein 0.0012 0.003 0.0094
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.004 0.0406 1
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0012 0.003 0.0099
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0012 0.003 0.0099
Echinococcus multilocularis tumor protein p63 0.0408 0.5357 0.5356
Schistosoma mansoni cellular tumor antigen P53 0.006 0.0677 0.0671
Loa Loa (eye worm) oxidoreductase 0.0012 0.003 0.0094
Echinococcus multilocularis oxidoreductase 0.0012 0.003 0.0029
Loa Loa (eye worm) oxidoreductase 0.0012 0.003 0.0094
Echinococcus multilocularis 3 ketodihydrosphingosine reductase 0.0012 0.003 0.0029
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0012 0.003 0.0099
Loa Loa (eye worm) hypothetical protein 0.0025 0.0209 0.0672
Echinococcus multilocularis GPCR, family 2 0.0019 0.0131 0.0129
Schistosoma mansoni cpg binding protein 0.0032 0.0308 0.0301
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0095 0.1152 0.115
Loa Loa (eye worm) hypothetical protein 0.006 0.0677 0.2194
Echinococcus multilocularis Smad4 0.001 0.0007 0.0005
Schistosoma mansoni steroid dehydrogenase 0.0012 0.003 0.0024
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0065 0.0743 0.0737
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0095 0.1152 0.115
Brugia malayi hypothetical protein 0.0012 0.003 0.0099
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0012 0.003 0.0024
Echinococcus multilocularis retinol dehydrogenase 11 0.0012 0.003 0.0029
Echinococcus granulosus carbonyl reductase 1 0.0012 0.003 0.0029
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0209 0.4742
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.004 0.0406 1
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.004 0.0406 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.003 0.0094
Mycobacterium leprae Probable short-chain type dehydrogenase/reductase 0.0012 0.003 0.5
Schistosoma mansoni steroid dehydrogenase 0.0012 0.003 0.0024
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.004 0.0406 0.1172
Echinococcus granulosus oxidoreductase 0.0012 0.003 0.0029
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0012 0.003 0.0099
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0012 0.003 0.0029
Entamoeba histolytica hypothetical protein 0.0112 0.1376 1
Leishmania major quinonoid dihydropteridine reductase 0.025 0.3237 1
Echinococcus granulosus tumor protein p63 0.0408 0.5357 0.5356
Brugia malayi MH2 domain containing protein 0.0144 0.1812 0.588
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0012 0.003 0.0099
Brugia malayi D-beta-hydroxybutyrate dehydrogenase, mitochondrial precursor 0.0012 0.003 0.0099
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0095 0.1152 0.115
Echinococcus granulosus epidermal retinal dehydrogenase 2 0.0012 0.003 0.0029
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0095 0.1152 0.115
Entamoeba histolytica hypothetical protein 0.0112 0.1376 1
Trichomonas vaginalis ap endonuclease, putative 0.004 0.0406 1
Brugia malayi hypothetical protein 0.0012 0.003 0.0099
Entamoeba histolytica hypothetical protein 0.0112 0.1376 1
Schistosoma mansoni hypothetical protein 0.0041 0.0428 0.0421
Echinococcus granulosus cpg binding protein 0.0032 0.0308 0.0306
Leishmania major hypothetical protein, conserved 0.0025 0.0209 0.0556
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0209 0.4742
Schistosoma mansoni short chain dehydrogenase 0.0012 0.003 0.0024
Schistosoma mansoni transcription factor LCR-F1 0.0112 0.1376 0.137
Schistosoma mansoni short chain dehydrogenase 0.0012 0.003 0.0024
Echinococcus multilocularis epidermal retinal dehydrogenase 2 0.0012 0.003 0.0029
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0209 0.0556
Brugia malayi Retinol dehydrogenase 12 0.0012 0.003 0.0099
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0011 0.0025 0.0023
Trypanosoma cruzi quinonoid dihydropteridine reductase, putative 0.025 0.3237 1
Loa Loa (eye worm) hypothetical protein 0.006 0.0684 0.2215
Echinococcus multilocularis retinol dehydrogenase 13 0.0012 0.003 0.0029
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0095 0.1152 0.1145
Schistosoma mansoni short chain dehydrogenase 0.0012 0.003 0.0024
Schistosoma mansoni hypothetical protein 0.0011 0.0025 0.0018
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.004 0.0406 0.0405
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.004 0.0406 0.1313
Echinococcus multilocularis geminin 0.0332 0.4336 0.4335
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0012 0.003 0.0099
Brugia malayi hypothetical protein 0.0025 0.0209 0.0677
Echinococcus granulosus WW domain containing oxidoreductase 0.0012 0.003 0.0029
Echinococcus multilocularis carbonyl reductase 1 0.0012 0.003 0.0029
Echinococcus granulosus smad 0.001 0.0007 0.0005
Schistosoma mansoni hypothetical protein 0.0332 0.4336 0.4332
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0095 0.1152 0.3734
Schistosoma mansoni dihydropteridine reductase 0.0239 0.3081 0.3076
Brugia malayi dehydrogenases, short chain protein 2 0.0012 0.003 0.0099
Loa Loa (eye worm) oxidoreductase 0.0012 0.003 0.0094
Loa Loa (eye worm) dehydrogenase 0.0012 0.003 0.0094
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.1812 0.5878
Mycobacterium leprae Probable oxidoreductase 0.0012 0.003 0.5
Schistosoma mansoni hypothetical protein 0.0332 0.4336 0.4332
Schistosoma mansoni oxidoreductase short chain dehydrogenase/reductase family 0.0012 0.003 0.0024
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.004 0.0406 1
Schistosoma mansoni steroid dehydrogenase 0.0012 0.003 0.0024
Loa Loa (eye worm) hypothetical protein 0.0012 0.003 0.0094
Loa Loa (eye worm) hypothetical protein 0.0157 0.1983 0.6434
Loa Loa (eye worm) hypothetical protein 0.0012 0.003 0.0094
Loa Loa (eye worm) hypothetical protein 0.0012 0.003 0.0094
Loa Loa (eye worm) hypothetical protein 0.0012 0.003 0.0094
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.004 0.0406 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.004 0.0406 0.1172
Loa Loa (eye worm) MH2 domain-containing protein 0.001 0.0007 0.0017
Echinococcus multilocularis steroid dehydrogenase 0.0012 0.003 0.0029
Brugia malayi Hypothetical oxidoreductase F56D1.5 0.0012 0.003 0.0099
Brugia malayi hypothetical protein 0.0157 0.1983 0.6435
Schistosoma mansoni carbonyl reductase 0.0012 0.003 0.0024
Mycobacterium leprae ROBABLE SHORT-CHAIN TYPE DEHYDROGENASE/REDUCTASE 0.0012 0.003 0.5
Echinococcus multilocularis NAD(P) binding domain 0.0239 0.3081 0.308
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.0684 0.2219
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0012 0.003 0.0029
Brugia malayi exodeoxyribonuclease III family protein 0.004 0.0406 0.1318
Schistosoma mansoni cpg binding protein 0.003 0.0284 0.0278
Echinococcus multilocularis cpg binding protein 0.0032 0.0308 0.0306
Echinococcus multilocularis microtubule associated protein 2 0.0754 1 1
Echinococcus granulosus mothers against decapentaplegic 5 0.001 0.0007 0.0005
Onchocerca volvulus 0.003 0.0284 0.13
Loa Loa (eye worm) hypothetical protein 0.0012 0.003 0.0094
Echinococcus granulosus carbonyl reductase 1 0.0012 0.003 0.0029
Echinococcus granulosus 3 ketodihydrosphingosine reductase 0.0012 0.003 0.0029
Brugia malayi MH2 domain containing protein 0.001 0.0007 0.0023
Echinococcus multilocularis smad 0.001 0.0007 0.0005
Echinococcus multilocularis carbonyl reductase 1 0.0012 0.003 0.0029
Loa Loa (eye worm) oxidoreductase 0.0012 0.003 0.0094
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0209 0.0584
Echinococcus multilocularis transient receptor potential cation channel 0.0012 0.003 0.0029
Onchocerca volvulus 0.006 0.0677 0.3313
Treponema pallidum exodeoxyribonuclease (exoA) 0.004 0.0406 0.5
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0012 0.003 0.0099
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.0684 0.2215
Loa Loa (eye worm) hypothetical protein 0.0041 0.0428 0.1384
Schistosoma mansoni hypothetical protein 0.0019 0.0131 0.0124
Echinococcus multilocularis Dehydrogenase:reductase SDR family 0.0012 0.003 0.0029
Echinococcus multilocularis steroid dehydrogenase 0.0012 0.003 0.0029
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.0684 0.2219
Echinococcus granulosus geminin 0.0332 0.4336 0.4335
Schistosoma mansoni short-chain dehydrogenase/reductase 0.0012 0.003 0.0024
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0012 0.003 0.0099
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0209 0.4742
Schistosoma mansoni retinal dehydrogenase 0.0012 0.003 0.0024
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0012 0.003 0.0099
Schistosoma mansoni short chain dehydrogenase 0.0012 0.003 0.0024
Echinococcus granulosus NADP binding domain 0.0239 0.3081 0.308
Echinococcus multilocularis carbonyl reductase 1 0.0012 0.003 0.0029
Schistosoma mansoni ap endonuclease 0.004 0.0406 0.0399
Leishmania major quinonoid dihydropteridine reductase 0.025 0.3237 1
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.004 0.0406 0.0405
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0011 0.0025 0.0023
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0209 0.4742
Leishmania major quinonoid dihydropteridine reductase 0.025 0.3237 1
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0019 0.0131 0.0129
Schistosoma mansoni hypothetical protein 0.0112 0.1376 0.137
Schistosoma mansoni steroid dehydrogenase 0.0012 0.003 0.0024
Loa Loa (eye worm) CXXC zinc finger family protein 0.003 0.0284 0.0918
Schistosoma mansoni steroid dehydrogenase 0.0012 0.003 0.0024
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0012 0.003 0.0099
Brugia malayi oxidoreductase 0.0012 0.003 0.0099
Loa Loa (eye worm) oxidoreductase 0.0012 0.003 0.0094
Echinococcus multilocularis retinol dehydrogenase 11 0.0012 0.003 0.0029
Mycobacterium leprae Possible short-chain dehydrogenase EphD 0.0012 0.003 0.5
Brugia malayi Smad1 0.001 0.0007 0.0023
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0019 0.0131 0.0425
Schistosoma mansoni short chain dehydrogenase 0.0012 0.003 0.0024
Echinococcus multilocularis estradiol 17 beta dehydrogenase 12 0.0012 0.003 0.0029
Echinococcus multilocularis conserved hypothetical protein 0.0012 0.003 0.0029
Echinococcus granulosus carbonyl reductase 1 0.0012 0.003 0.0029
Loa Loa (eye worm) hypothetical protein 0.0012 0.003 0.0094
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0012 0.003 0.0099
Echinococcus multilocularis mothers against decapentaplegic 5 0.001 0.0007 0.0005
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0019 0.0131 0.0129
Echinococcus granulosus GPCR family 2 0.0019 0.0131 0.0129
Leishmania major quinonoid dihydropteridine reductase 0.025 0.3237 1
Schistosoma mansoni hypothetical protein 0.0019 0.0131 0.0124
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0112 0.1376 0.1374
Echinococcus granulosus Dehydrogenase:reductase SDR family 0.0012 0.003 0.0029
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0095 0.1152 0.1145
Onchocerca volvulus 0.0157 0.1983 1
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.1812 0.5878
Echinococcus granulosus TGF beta signal transducer SmadC 0.001 0.0007 0.0005
Loa Loa (eye worm) short chain dehydrogenase/reductase family oxidoreductase 0.0012 0.003 0.0094
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0012 0.003 0.0099
Schistosoma mansoni short chain dehydrogenase 0.0012 0.003 0.0024
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0012 0.003 0.0099
Entamoeba histolytica hypothetical protein 0.0112 0.1376 1
Echinococcus granulosus retinol dehydrogenase 11 0.0012 0.003 0.0029
Brugia malayi dehydrogenases, short chain protein 9 0.0012 0.003 0.0099
Schistosoma mansoni cpg binding protein 0.0032 0.0308 0.0301
Echinococcus granulosus Smad4 0.001 0.0007 0.0005
Leishmania major quinonoid dihydropteridine reductase 0.025 0.3237 1
Brugia malayi Dehydrogenases, short chain protein 30 0.0012 0.003 0.0099
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0095 0.1152 0.1145
Loa Loa (eye worm) oxidoreductase 0.0012 0.003 0.0094
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0012 0.003 0.0099
Brugia malayi MH1 domain containing protein 0.001 0.0007 0.0023
Brugia malayi dihydropteridine reductase-like 0.0239 0.3081 1
Mycobacterium leprae Probable short-chain type dehydrogenase/reductase 0.0012 0.003 0.5
Schistosoma mansoni hypothetical protein 0.0019 0.0131 0.0124
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0019 0.0131 0.0129
Entamoeba histolytica exodeoxyribonuclease III, putative 0.004 0.0406 0.2792
Echinococcus multilocularis carbonyl reductase 1 0.0012 0.003 0.0029
Loa Loa (eye worm) oxidoreductase 0.0012 0.003 0.0094
Echinococcus granulosus steroid dehydrogenase 0.0012 0.003 0.0029
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0112 0.1376 0.1374

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 0.0158 um PUBCHEM_BIOASSAY: qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53ts Cells at the Nonpermissive Temperature. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 17.7828 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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