Detailed information for compound 906910

Basic information

Technical information
  • TDR Targets ID: 906910
  • Name: 2-methylpropyl 4-(2,3-dimethoxyphenyl)-6-meth yl-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxyl ate
  • MW: 348.394 | Formula: C18H24N2O5
  • H donors: 2 H acceptors: 2 LogP: 2.29 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1c(OC)cccc1C1NC(=O)NC(=C1C(=O)OCC(C)C)C
  • InChi: 1S/C18H24N2O5/c1-10(2)9-25-17(21)14-11(3)19-18(22)20-15(14)12-7-6-8-13(23-4)16(12)24-5/h6-8,10,15H,9H2,1-5H3,(H2,19,20,22)
  • InChiKey: NGZCQSQYVHZGON-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • isobutyl 4-(2,3-dimethoxyphenyl)-6-methyl-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxylate
  • 4-(2,3-dimethoxyphenyl)-6-methyl-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxylic acid isobutyl ester
  • 4-(2,3-dimethoxyphenyl)-2-keto-6-methyl-3,4-dihydro-1H-pyrimidine-5-carboxylic acid isobutyl ester
  • Oprea1_691183
  • AG-205/11768094
  • Oprea1_274696
  • BAS 00915496
  • UNM000000526801
  • EU-0069830
  • A1848/0077758

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Bloom's syndrome protein homolog 0.0045 0.0741 0.0736
Echinococcus multilocularis dna polymerase kappa 0.0118 0.2282 0.2276
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0297 0.6055 1
Brugia malayi Pre-SET motif family protein 0.0247 0.5007 0.5267
Mycobacterium ulcerans DNA polymerase IV 0.0118 0.2282 0.3716
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0548 0.0862
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0018 0.019 0.015
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0039 0.0627 0.1738
Mycobacterium tuberculosis Probable phosphoglycerate kinase Pgk 0.0167 0.3326 0.6916
Entamoeba histolytica recQ family helicase, putative 0.0024 0.0304 0.0914
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0097 0.1834 0.1834
Echinococcus granulosus GPCR family 2 0.0066 0.12 0.1193
Plasmodium falciparum LCCL domain-containing protein 0.0023 0.0294 0.0718
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0548 0.0528
Trypanosoma cruzi DNA polymerase eta, putative 0.0143 0.2811 0.4589
Schistosoma mansoni DNA helicase recq5 0.0018 0.019 0.019
Brugia malayi ImpB/MucB/SamB family protein 0.0143 0.2811 0.2934
Schistosoma mansoni cpg binding protein 0.0034 0.0518 0.0518
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0548 0.1495
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0042 0.0682 0.1038
Toxoplasma gondii phosphatidylinositol-4-phosphate 5-kinase 0.0013 0.0073 0.0218
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0097 0.1834 0.1834
Trypanosoma cruzi phosphatidylinositol-4-phosphate 5-kinase, putative 0.0013 0.0073 0.0022
Trypanosoma cruzi hypothetical protein, conserved 0.0028 0.0401 0.057
Trichomonas vaginalis glutaminase, putative 0.0269 0.5462 0.9538
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0061 0.1096 0.1729
Trypanosoma brucei DNA polymerase kappa, putative 0.007 0.1269 0.2018
Mycobacterium tuberculosis Conserved hypothetical protein 0.0156 0.3096 0.6343
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0548 0.0862
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0097 0.1834 0.1828
Loa Loa (eye worm) hypothetical protein 0.0018 0.019 0.0147
Trypanosoma brucei phosphoglycerate kinase, putative 0.0061 0.1096 0.1729
Leishmania major DNA polymerase kappa, putative 0.0028 0.0401 0.057
Trypanosoma brucei DNA polymerase IV, putative 0.0118 0.2282 0.3707
Entamoeba histolytica NLI interacting factor-like phosphatase domain-containing protein 0.0012 0.0059 0.0178
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0034 0.0519 0.0512
Brugia malayi Doublecortin family protein 0.0023 0.0294 0.0261
Trypanosoma cruzi DNA polymerase kappa, putative 0.0118 0.2282 0.3707
Echinococcus granulosus bloom syndrome protein 0.0045 0.0741 0.0734
Loa Loa (eye worm) hypothetical protein 0.016 0.3168 0.3311
Echinococcus granulosus phosphoglycerate kinase 1 0.0167 0.3326 0.3321
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0548 0.0862
Trypanosoma brucei DNA polymerase kappa, putative 0.0098 0.1868 0.3016
Trichomonas vaginalis phosphoglycerate kinase, putative 0.0167 0.3326 0.5767
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0018 0.019 0.015
Trichomonas vaginalis phosphoglycerate kinase, putative 0.0167 0.3326 0.5767
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0297 0.6055 1
Echinococcus granulosus Polycystic kidney disease protein 0.0023 0.0294 0.0287
Echinococcus granulosus phosphatidylinositol 5 phosphate 4 kinase type 2 0.016 0.3168 0.3162
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0066 0.12 0.1193
Trypanosoma brucei unspecified product 0.0063 0.1133 0.179
Schistosoma mansoni hypothetical protein 0.0353 0.7232 0.7232
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0042 0.0682 0.1038
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0548 0.0815
Brugia malayi beta-lactamase 0.0035 0.0548 0.053
Giardia lamblia Sgs1 DNA helicase, putative 0.0018 0.019 0.04
Brugia malayi ImpB/MucB/SamB family protein 0.0092 0.1731 0.1788
Schistosoma mansoni phosphatidylinositol-4-phosphate 5-kinase type II 0.0013 0.0073 0.0073
Leishmania major DNA damage repair protein, putative 0.0028 0.0401 0.057
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0066 0.12 0.1193
Mycobacterium ulcerans hypothetical protein 0.0156 0.3096 0.5325
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0247 0.5007 0.5265
Loa Loa (eye worm) hypothetical protein 0.0012 0.0056 0.0005
Schistosoma mansoni phosphatidylinositol-4-phosphate 5-kinase type II 0.016 0.3168 0.3168
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.003 0.043 0.1292
Leishmania major mitochondrial DNA polymerase beta 0.0297 0.6055 1
Echinococcus granulosus histone lysine methyltransferase setb 0.0036 0.0562 0.0555
Brugia malayi beta-lactamase family protein 0.0035 0.0548 0.053
Trypanosoma brucei DNA damage repair protein, putative 0.0028 0.0401 0.057
Trypanosoma cruzi phosphatidylinositol (3,5) kinase, putative 0.0013 0.0073 0.0022
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0562 0.0562
Loa Loa (eye worm) RecQ helicase 0.0045 0.0741 0.0733
Trypanosoma brucei phosphatidylinositol phosphate kinase alpha 0.0013 0.0073 0.0022
Schistosoma mansoni hypothetical protein 0.0066 0.12 0.12
Echinococcus granulosus geminin 0.0353 0.7232 0.723
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0118 0.2282 0.3924
Schistosoma mansoni rab6-interacting 0.0023 0.0294 0.0294
Trypanosoma brucei phosphoglycerate kinase 0.0061 0.1096 0.1729
Brugia malayi FYVE finger-containing phosphoinositide kinase, putative 0.0013 0.0073 0.0026
Schistosoma mansoni phosphatidylinositol-4-phosphate 5-kinase type II 0.0013 0.0073 0.0073
Trypanosoma brucei DNA polymerase kappa, putative 0.0118 0.2282 0.3707
Trypanosoma cruzi hypothetical protein, conserved 0.0028 0.0401 0.057
Leishmania major DNA polymerase eta, putative 0.0143 0.2811 0.4589
Toxoplasma gondii hypothetical protein 0.0048 0.0811 0.2438
Plasmodium falciparum phosphoglycerate kinase 0.0167 0.3326 1
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0066 0.12 0.1193
Onchocerca volvulus 0.0034 0.0518 0.0413
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0024 0.0304 0.0408
Echinococcus multilocularis Phosphatidylinositol 4 phosphate 5 kinase type 1 0.0013 0.0073 0.0065
Loa Loa (eye worm) hypothetical protein 0.0143 0.2822 0.2943
Brugia malayi glutaminase DH11.1 0.0269 0.5462 0.5751
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.0548 0.029
Brugia malayi beta-lactamase family protein 0.0035 0.0548 0.053
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0562 0.0562
Loa Loa (eye worm) FYVE finger-containing phosphoinositide kinase 0.0013 0.0073 0.0023
Onchocerca volvulus 0.016 0.3168 0.5293
Echinococcus multilocularis geminin 0.0353 0.7232 0.723
Schistosoma mansoni DNA helicase recq1 0.0018 0.019 0.019
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0141 0.2762 0.4507
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0098 0.1868 0.3286
Plasmodium falciparum phosphatidylinositol-4-phosphate 5-kinase 0.0013 0.0073 0.004
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0065 0.1179 0.1172
Echinococcus multilocularis phosphoglycerate kinase 1 0.0167 0.3326 0.3321
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0548 0.0862
Trypanosoma cruzi DNA polymerase kappa, putative 0.0118 0.2282 0.3707
Toxoplasma gondii phosphatidylinositol-4-phosphate 5-Kinase 0.0013 0.0073 0.0218
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0012 0.0051 0.0044
Trypanosoma cruzi DNA damage repair protein, putative 0.0028 0.0401 0.057
Trypanosoma brucei DNA polymerase IV, putative 0.0111 0.2145 0.3479
Loa Loa (eye worm) hypothetical protein 0.0136 0.2657 0.2768
Loa Loa (eye worm) CXXC zinc finger family protein 0.0034 0.0518 0.0496
Mycobacterium tuberculosis Conserved hypothetical protein 0.0092 0.1731 0.2946
Entamoeba histolytica deoxycytidyl transferase, putative 0.0092 0.1731 0.5206
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0018 0.019 0.0182
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0035 0.0538 0.1617
Brugia malayi hypothetical protein 0.0023 0.0294 0.0261
Leishmania major hypothetical protein, conserved 0.0035 0.0548 0.0815
Plasmodium vivax SET domain protein, putative 0.0036 0.0562 0.154
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0167 0.3326 0.5448
Trypanosoma brucei phosphatidylinositol-4-phosphate 5-kinase, putative 0.0013 0.0073 0.0022
Schistosoma mansoni lipoxygenase 0.0023 0.0294 0.0294
Echinococcus multilocularis 0.0012 0.0059 0.0052
Echinococcus multilocularis phosphatidylinositol phosphate 5 kinase type III 0.0013 0.0073 0.0065
Trypanosoma brucei DNA damage repair protein, putative 0.0028 0.0401 0.057
Schistosoma mansoni DNA polymerase eta 0.0143 0.2811 0.2811
Toxoplasma gondii phosphoglycerate kinase PGKII 0.0167 0.3326 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.0562 0.0543
Loa Loa (eye worm) hypothetical protein 0.0023 0.0294 0.0258
Leishmania major phosphoglycerate kinase B, cytosolic 0.0167 0.3326 0.5448
Chlamydia trachomatis phosphoglycerate kinase 0.0167 0.3326 0.5
Loa Loa (eye worm) hypothetical protein 0.0035 0.0548 0.0528
Trypanosoma brucei DNA polymerase kappa, putative 0.0118 0.2282 0.3707
Onchocerca volvulus 0.0035 0.0548 0.0468
Schistosoma mansoni rab6-interacting 0.0023 0.0294 0.0294
Schistosoma mansoni hypothetical protein 0.0143 0.2822 0.2822
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0141 0.2762 0.4507
Giardia lamblia DINP protein human, muc B family 0.0098 0.1868 0.5536
Trypanosoma cruzi DNA polymerase kappa, putative 0.0118 0.2282 0.3707
Trypanosoma brucei phosphoglycerate kinase 0.0167 0.3326 0.5448
Trypanosoma brucei DNA polymerase eta, putative 0.0143 0.2811 0.4589
Trichomonas vaginalis phosphatidylinositol-4-phosphate 5-kinase type II, putative 0.0013 0.0073 0.0023
Trypanosoma cruzi DNA polymerase kappa, putative 0.0118 0.2282 0.3707
Trypanosoma brucei DNA polymerase kappa, putative 0.0055 0.0952 0.1488
Trichomonas vaginalis DNA helicase recq, putative 0.0045 0.0741 0.1204
Schistosoma mansoni blooms syndrome DNA helicase 0.0035 0.0544 0.0544
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0548 0.0815
Echinococcus multilocularis lipoxygenase domain containing protein 0.0023 0.0294 0.0287
Echinococcus granulosus lipoxygenase domain containing protein 0.0023 0.0294 0.0287
Mycobacterium ulcerans beta-lactamase 0.0035 0.0548 0.029
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0097 0.1834 0.1828
Mycobacterium leprae Probable phosphoglycerate kinase Pgk 0.0167 0.3326 1
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0548 0.0815
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0036 0.0562 0.0555
Trypanosoma cruzi DNA polymerase eta, putative 0.008 0.1481 0.2371
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0066 0.12 0.1193
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0018 0.019 0.0182
Echinococcus multilocularis phosphatidylinositol 5 phosphate 4 kinase type 2 0.016 0.3168 0.3162
Onchocerca volvulus 0.0281 0.5724 1
Loa Loa (eye worm) hypothetical protein 0.0167 0.3326 0.348
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0098 0.1868 0.3016
Brugia malayi latrophilin 2 splice variant baaae 0.0143 0.2822 0.2946
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0548 0.0548
Trypanosoma brucei DNA polymerase kappa, putative 0.0118 0.2282 0.3707
Echinococcus multilocularis dnaJ subfamily B 0.0484 1 1
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0141 0.2762 0.4507
Schistosoma mansoni hypothetical protein 0.0484 1 1
Trypanosoma cruzi phosphatidylinositol-4-phosphate 5-kinase, putative 0.0013 0.0073 0.0022
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0018 0.019 0.0571
Plasmodium vivax DNA repair protein REV1, putative 0.0028 0.0401 0.1046
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0682 0.1038
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0562 0.0562
Trypanosoma brucei DNA polymerase kappa, putative 0.007 0.1269 0.2018
Schistosoma mansoni hypothetical protein 0.0066 0.12 0.12
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0018 0.019 0.0182
Plasmodium vivax multidomain scavenger receptor, putative 0.0023 0.0294 0.0718
Giardia lamblia DNA damage repair protein 0.0028 0.0401 0.1046
Schistosoma mansoni lipoxygenase 0.0065 0.1179 0.1179
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0051 0.0874 0.1359
Echinococcus granulosus CTD small phosphatase protein like 0.0012 0.0059 0.0052
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0066 0.12 0.1223
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0024 0.0304 0.0408
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0065 0.1179 0.1172
Schistosoma mansoni hypothetical protein 0.0066 0.12 0.12
Onchocerca volvulus 0.0035 0.0548 0.0468
Schistosoma mansoni glutaminase 0.0269 0.5462 0.5462
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0073 0.1349 0.1349
Giardia lamblia Hypothetical protein 0.0013 0.0073 0.004
Mycobacterium ulcerans phosphoglycerate kinase 0.0167 0.3326 0.5779
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.0548 0.029
Echinococcus multilocularis Carboxy terminal domain RNA polymerase II 0.0012 0.0059 0.0052
Trypanosoma brucei DNA polymerase kappa, putative 0.0118 0.2282 0.3707
Loa Loa (eye worm) pip kinase 2 0.016 0.3168 0.3311
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0548 0.0548
Echinococcus multilocularis cpg binding protein 0.0036 0.0559 0.0552
Echinococcus granulosus cpg binding protein 0.0036 0.0559 0.0552
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0548 0.0541
Brugia malayi hypothetical protein 0.0023 0.0294 0.0261
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0018 0.019 0.0147
Brugia malayi Phosphoglycerate kinase 0.0061 0.1096 0.1113
Echinococcus multilocularis bloom syndrome protein 0.0045 0.0741 0.0734
Plasmodium vivax phosphatidylinositol-4-phosphate 5-kinase, putative 0.0013 0.0073 0.004
Loa Loa (eye worm) hypothetical protein 0.0055 0.0952 0.0957
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0092 0.1731 0.1785
Echinococcus multilocularis GPCR, family 2 0.0066 0.12 0.1193
Schistosoma mansoni hypothetical protein 0.0012 0.0056 0.0056
Trichomonas vaginalis set domain proteins, putative 0.0281 0.5724 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0118 0.2282 0.3707
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0097 0.1834 0.1828
Loa Loa (eye worm) latrophilin receptor protein 2 0.0066 0.12 0.122
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0548 0.053
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0036 0.0562 0.0555
Leishmania major phosphatidylinositol-4-phosphate-5-kinase-likep ro tein 0.0013 0.0073 0.0022
Brugia malayi Carboxy-terminal domain RNA polymerase II polypeptide A smallphosphatase 1 0.0012 0.0059 0.0012
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0226 0.4565 1
Brugia malayi Pip kinase protein 1 0.0013 0.0073 0.0026
Schistosoma mansoni phosphatidylinositol-4-phosphate-5-kinaseputativ e 0.0013 0.0073 0.0073
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0061 0.1096 0.1729
Schistosoma mansoni polycystin 1-related 0.0023 0.0294 0.0294
Loa Loa (eye worm) beta-lactamase 0.0035 0.0548 0.0528
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0297 0.6055 1
Trypanosoma brucei DNA polymerase IV, putative 0.0118 0.2282 0.3707
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0028 0.0401 0.1206
Loa Loa (eye worm) pigment dispersing factor receptor c 0.021 0.4219 0.4428
Echinococcus multilocularis lipoxygenase domain containing protein 0.0023 0.0294 0.0287
Leishmania major DNA polymerase eta, putative 0.008 0.1481 0.2371
Schistosoma mansoni phosphoglycerate kinase 0.0167 0.3326 0.3326
Schistosoma mansoni phosphoglycerate kinase 0.0167 0.3326 0.3326
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0097 0.1834 0.1897
Trypanosoma brucei DNA polymerase kappa, putative 0.0118 0.2282 0.3707
Trypanosoma cruzi phosphatidylinositol-4-phosphate 5-kinase, putative 0.0013 0.0073 0.0022
Trichomonas vaginalis esterase, putative 0.0035 0.0548 0.0862
Loa Loa (eye worm) hypothetical protein 0.0143 0.2811 0.2932
Schistosoma mansoni hypothetical protein 0.0066 0.12 0.12
Trypanosoma brucei unspecified product 0.0063 0.1133 0.179
Trypanosoma cruzi phosphatidylinositol-4-phosphate 5-kinase-like, putative 0.0013 0.0073 0.0022
Plasmodium falciparum DNA repair protein REV1, putative 0.0028 0.0401 0.1046
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0167 0.3326 0.5448
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0061 0.1096 0.1729
Trypanosoma cruzi phosphatidylinositol-4-phosphate 5-kinase type II beta, putative 0.0013 0.0073 0.0022
Echinococcus granulosus Carboxy terminal domain RNA polymerase II 0.0012 0.0059 0.0052
Trypanosoma brucei unspecified product 0.0111 0.2145 0.3479
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0459 0.9463 1
Schistosoma mansoni nuclear lim interactor-interacting factor (nli-interacting factor) (nli-if) 0.0012 0.0059 0.0059
Trypanosoma cruzi phosphatidylinositol 4-phosphate 5-kinase alpha, putative 0.0013 0.0073 0.0022
Trypanosoma brucei hypothetical protein, conserved 0.0028 0.0401 0.057
Treponema pallidum phosphoglycerate kinase 0.0167 0.3326 1
Leishmania major phosphatidylinositol (3,5) kinase, putative 0.0013 0.0073 0.0022
Schistosoma mansoni loxhd1 0.0023 0.0294 0.0294
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0018 0.019 0.0182
Echinococcus granulosus RUN 0.0023 0.0294 0.0287
Mycobacterium ulcerans hypothetical protein 0.0035 0.0548 0.029
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0097 0.1834 0.1828
Echinococcus granulosus dna polymerase eta 0.0143 0.2811 0.2806
Loa Loa (eye worm) hypothetical protein 0.0035 0.0548 0.0528
Leishmania major phosphatidylinositol-4-phosphate 5-kinase-like protein 0.0013 0.0073 0.0022
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0097 0.1834 0.1894
Loa Loa (eye worm) pip kinase 1 0.0013 0.0073 0.0023
Brugia malayi Latrophilin receptor protein 2 0.0066 0.12 0.1223
Toxoplasma gondii phosphoglycerate kinase PGKI 0.0167 0.3326 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0548 0.0528
Trypanosoma brucei chrX additional, unordered contigs 0.0028 0.0401 0.057
Onchocerca volvulus 0.0035 0.0548 0.0468
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0024 0.0304 0.0408
Loa Loa (eye worm) hypothetical protein 0.0023 0.0294 0.0258
Entamoeba histolytica phosphoinositide kinase, putative 0.0013 0.0073 0.0218
Schistosoma mansoni phosphatidylinositol-4-phosphate 5-kinase type I 0.0013 0.0073 0.0073
Leishmania major phosphoglycerate kinase C, glycosomal 0.0167 0.3326 0.5448
Schistosoma mansoni DNA polymerase IV / kappa 0.0028 0.0401 0.0401
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0012 0.0051 0.0044
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0018 0.019 0.04
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.003 0.0437 0.1157
Loa Loa (eye worm) hypothetical protein 0.0035 0.0548 0.0528
Trypanosoma brucei phosphatidylinositol-4-phosphate 5-kinase, putative 0.0013 0.0073 0.0022
Loa Loa (eye worm) hypothetical protein 0.021 0.4219 0.4428
Toxoplasma gondii ImpB/MucB/SamB family protein 0.008 0.1481 0.4452
Echinococcus granulosus phosphatidylinositol phosphate 5 kinase type III 0.0013 0.0073 0.0065
Toxoplasma gondii Dullard family phosphatase domain-containing protein 0.0012 0.0059 0.0178
Loa Loa (eye worm) hypothetical protein 0.0035 0.0548 0.0528
Trypanosoma brucei DNA polymerase kappa, putative 0.007 0.1269 0.2018
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0061 0.1096 0.1729
Echinococcus granulosus dna polymerase kappa 0.0118 0.2282 0.2276
Trypanosoma cruzi DNA damage repair protein, putative 0.0028 0.0401 0.057
Schistosoma mansoni nuclear lim interactor-interacting factor (nli-interacting factor) (nli-if) 0.0012 0.0059 0.0059
Brugia malayi polk-prov protein 0.0055 0.0952 0.0959
Brugia malayi Pre-SET motif family protein 0.0036 0.0562 0.0546
Loa Loa (eye worm) hypothetical protein 0.0035 0.0548 0.0528
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0092 0.1731 0.1725
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0548 0.0541
Trypanosoma brucei phosphatidylinositol (3,5) kinase, putative 0.0013 0.0073 0.0022
Schistosoma mansoni cpg binding protein 0.0036 0.0559 0.0559
Mycobacterium ulcerans glutaminase 0.0269 0.5462 1
Entamoeba histolytica phosphoglycerate kinase, putative 0.0167 0.3326 1
Leishmania major phosphatidylinositol-4-phosphate 5-kinase-like, putative 0.0013 0.0073 0.0022
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0682 0.1038
Brugia malayi CXXC zinc finger family protein 0.0034 0.0518 0.0499
Schistosoma mansoni phosphatidylinositol-4-phosphate 5-kinase type II 0.016 0.3168 0.3168
Loa Loa (eye worm) hypothetical protein 0.0012 0.0059 0.0008
Loa Loa (eye worm) FYVE zinc finger family protein 0.0013 0.0073 0.0023
Trypanosoma brucei DNA polymerase kappa, putative 0.0118 0.2282 0.3707
Loa Loa (eye worm) doublecortin family protein 0.0023 0.0294 0.0258
Giardia lamblia Phosphoglycerate kinase 0.0167 0.3326 1
Echinococcus multilocularis dna polymerase eta 0.0143 0.2811 0.2806
Toxoplasma gondii ABC1 family protein 0.0035 0.0548 0.1647
Echinococcus multilocularis Polycystic kidney disease protein 0.0023 0.0294 0.0287
Toxoplasma gondii histone lysine methyltransferase SET1 0.0066 0.1186 0.3567
Schistosoma mansoni cpg binding protein 0.0036 0.0559 0.0559
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.021 0.4219 0.443
Mycobacterium ulcerans lipase LipD 0.0035 0.0548 0.029
Loa Loa (eye worm) glutaminase 0.0269 0.5462 0.5749
Schistosoma mansoni mixed-lineage leukemia protein mll 0.001 0.0008 0.0008
Schistosoma mansoni terminal deoxycytidyl transferase 0.0092 0.1731 0.1731
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0548 0.0862
Brugia malayi Phosphoglycerate kinase 0.0167 0.3326 0.3482
Brugia malayi Calcitonin receptor-like protein seb-1 0.021 0.4219 0.443
Echinococcus granulosus lipoxygenase domain containing protein 0.0023 0.0294 0.0287
Trichomonas vaginalis DNA polymerase eta, putative 0.0118 0.2282 0.3924
Trypanosoma brucei phosphoglycerate kinase 0.0167 0.3326 0.5448
Echinococcus granulosus Phosphatidylinositol 4 phosphate 5 kinase type 1 0.0013 0.0073 0.0065
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0036 0.0562 0.0562
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0092 0.1731 0.1725
Leishmania major DNA polymerase kappa, putative 0.0098 0.1868 0.3016
Loa Loa (eye worm) glutaminase 2 0.0269 0.5462 0.5749
Trypanosoma cruzi phosphatidylinositol-4-phosphate 5-kinase-like, putative 0.0013 0.0073 0.0022
Loa Loa (eye worm) hypothetical protein 0.0066 0.12 0.122
Brugia malayi follicle stimulating hormone receptor 0.0459 0.9463 1
Trichomonas vaginalis DNA helicase recq, putative 0.0024 0.0304 0.0432
Trichomonas vaginalis phosphatidylinositol-4-phosphate 5-kinase type II, putative 0.0013 0.0073 0.0023
Schistosoma mansoni hypothetical protein 0.0353 0.7232 0.7232
Trypanosoma brucei DNA polymerase kappa, putative 0.0118 0.2282 0.3707
Trypanosoma cruzi 3-phosphoglycerate kinase, glycosomal 0.0061 0.1096 0.1729
Plasmodium vivax hypothetical protein, conserved 0.0013 0.0073 0.004
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0092 0.1731 0.1731
Giardia lamblia Phosphatidylinositol-4-phosphate 5-kinase, putative 0.0013 0.0073 0.004
Mycobacterium ulcerans DNA polymerase IV 0.0118 0.2282 0.3716
Schistosoma mansoni hypothetical protein 0.0023 0.0294 0.0294
Toxoplasma gondii phosphatidylinositol-4-phosphate 5-Kinase 0.0013 0.0073 0.0218
Plasmodium vivax phosphoglycerate kinase, putative 0.0167 0.3326 1
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0036 0.0562 0.1691
Onchocerca volvulus 0.0036 0.0562 0.0494
Brugia malayi Pip kinase protein 2 0.016 0.3168 0.3313
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0061 0.1096 0.1729
Trichomonas vaginalis DNA helicase recq1, putative 0.0045 0.0741 0.1204
Echinococcus multilocularis RUN 0.0023 0.0294 0.0287
Wolbachia endosymbiont of Brugia malayi phosphoglycerate kinase 0.0167 0.3326 0.5
Entamoeba histolytica phosphatidylinositol-4-phosphate 5-kinase, putative 0.0013 0.0073 0.0218
Trypanosoma brucei DNA polymerase kappa, putative 0.0055 0.0952 0.1488
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0097 0.1834 0.1834
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0018 0.019 0.0571
Trypanosoma brucei DNA polymerase kappa, putative 0.0118 0.2282 0.3707
Trypanosoma brucei hypothetical protein, conserved 0.0028 0.0401 0.057

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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