Detailed information for compound 910642

Basic information

Technical information
  • TDR Targets ID: 910642
  • Name: 3-[2-(4-bromophenyl)-2-oxoethyl]-1-[(4-chloro phenyl)methyl]-3-hydroxyindol-2-one
  • MW: 470.743 | Formula: C23H17BrClNO3
  • H donors: 1 H acceptors: 3 LogP: 4.9 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1ccc(cc1)CN1c2ccccc2C(C1=O)(O)CC(=O)c1ccc(cc1)Br
  • InChi: 1S/C23H17BrClNO3/c24-17-9-7-16(8-10-17)21(27)13-23(29)19-3-1-2-4-20(19)26(22(23)28)14-15-5-11-18(25)12-6-15/h1-12,29H,13-14H2
  • InChiKey: ORVGSHVBBOPSIW-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3-[2-(4-bromophenyl)-2-oxo-ethyl]-1-[(4-chlorophenyl)methyl]-3-hydroxy-indolin-2-one
  • 3-[2-(4-bromophenyl)-2-oxoethyl]-1-[(4-chlorophenyl)methyl]-3-hydroxy-2-indolinone
  • 3-[2-(4-bromophenyl)-2-keto-ethyl]-1-(4-chlorobenzyl)-3-hydroxy-oxindole
  • 3-[2-(4-bromophenyl)-2-oxo-ethyl]-1-[(4-chlorophenyl)methyl]-3-hydroxy-indol-2-one
  • Oprea1_179871
  • STK048659
  • EU-0008509
  • AK-778/15446020

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0331 0.7099 0.8958
Plasmodium falciparum amino acid transporter, putative 0.0025 0.0359 0.1194
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.1213 0.1578
Schistosoma mansoni opsin-like receptor 0.0014 0.0115 0.0115
Loa Loa (eye worm) hypothetical protein 0.0011 0.0057 0.0026
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0013 0.0104 0.0168
Echinococcus granulosus rhodopsin orphan GPCR 0.0014 0.0115 0.0186
Brugia malayi G protein-coupled receptor 0.0014 0.0115 0.0116
Brugia malayi hypothetical protein 0.0014 0.0115 0.0116
Schistosoma mansoni Tr4/Tr2 (homologue) 0.001 0.0037 0.0037
Loa Loa (eye worm) pyridine nucleotide-disufhide oxidoreductase 0.0013 0.0104 0.0088
Echinococcus granulosus thioredoxin glutathione reductase 0.0145 0.3006 0.4853
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0014 0.0115 0.0186
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0013 0.0099 0.016
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0099 0.016
Plasmodium falciparum type II NADH:ubiquinone oxidoreductase 0.0013 0.0104 0.0347
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 0.0034 0.0564 0.0735
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0037 0.0037
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0037 0.0037
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.005 0.0918 0.1195
Plasmodium vivax type II NADH:ubiquinone oxidoreductase, putative 0.0013 0.0104 0.0347
Loa Loa (eye worm) hypothetical protein 0.0147 0.3041 0.3929
Trypanosoma brucei ERV/ALR sulfhydryl oxidase domain-containing protein 0.0034 0.0564 0.0735
Onchocerca volvulus 0.0014 0.0115 0.0127
Trypanosoma cruzi polo-like protein kinase, putative 0.0289 0.6193 0.8062
Schistosoma mansoni coup transcription factor 0.001 0.0037 0.0037
Echinococcus granulosus NADPH:adrenodoxin oxidoreductase 0.0013 0.0104 0.0168
Brugia malayi hypothetical protein 0.0014 0.0115 0.0116
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0013 0.0104 0.0168
Leishmania major acetoin dehydrogenase e3 component-like protein 0.005 0.0918 0.1073
Giardia lamblia Kinase, PLK 0.0289 0.6193 1
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0025 0.0359 0.0877
Brugia malayi nuclear hormone receptor 0.001 0.0037 0.0037
Schistosoma mansoni cathepsin F (C01 family) 0.0017 0.0178 0.0178
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0178 0.0288
Echinococcus multilocularis rhodopsin orphan GPCR 0.0014 0.0115 0.0186
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.005 0.0918 0.1195
Trypanosoma cruzi C-8 sterol isomerase, putative 0.0357 0.7682 1
Echinococcus granulosus ecdysone induced protein 78C 0.001 0.0037 0.0059
Trichomonas vaginalis dihydrolipoamide dehydrogenase, putative 0.0013 0.0104 0.0168
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0025 0.0359 0.0579
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0017 0.0178 0.0594
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0145 0.3006 0.3716
Brugia malayi Cytochrome P450 family protein 0.0024 0.0335 0.0337
Toxoplasma gondii NADPH-glutathione reductase 0.005 0.0918 0.2803
Echinococcus granulosus neuropeptide receptor A26 0.0014 0.0115 0.0186
Schistosoma mansoni neuropeptide receptor 0.0014 0.0115 0.0115
Brugia malayi steroid hormone receptor 0.001 0.0037 0.0037
Plasmodium falciparum transporter, putative 0.0025 0.0359 0.1194
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.005 0.0918 0.1073
Echinococcus multilocularis fmrfamide receptor 0.0014 0.0115 0.0186
Brugia malayi Dopamine receptor protein 2 0.0014 0.0115 0.0116
Loa Loa (eye worm) hypothetical protein 0.0357 0.7682 1
Echinococcus granulosus neuropeptides capa receptor 0.0014 0.0115 0.0186
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.0025 0.0359 0.0579
Trypanosoma brucei hypothetical protein, conserved 0.0013 0.0104 0.0136
Trichomonas vaginalis CAMK family protein kinase 0.0289 0.6193 1
Schistosoma mansoni sodium/chloride dependent transporter 0.0147 0.3041 0.3041
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0014 0.0115 0.0115
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0014 0.0115 0.0115
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0122 0.2505 0.4045
Loa Loa (eye worm) hypothetical protein 0.0014 0.0115 0.0103
Trypanosoma brucei NADH dehydrogenase 0.0013 0.0104 0.0136
Brugia malayi GnHR receptor homolog 0.0014 0.0115 0.0116
Schistosoma mansoni neuropeptide receptor 0.0014 0.0115 0.0115
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0289 0.6193 1
Loa Loa (eye worm) neuropeptide F receptor 0.0014 0.0115 0.0103
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0017 0.0178 0.0288
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.005 0.0918 0.2803
Brugia malayi Melatonin receptor type 1A 0.0014 0.0115 0.0116
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0122 0.2505 0.3168
Schistosoma mansoni biogenic amine receptor 0.0014 0.0115 0.0115
Loa Loa (eye worm) hypothetical protein 0.0014 0.0115 0.0103
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0178 0.0288
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0037 0.0059
Echinococcus granulosus neuropeptide FF receptor 2 0.0014 0.0115 0.0186
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.001 0.0037 0.0059
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0099 0.016
Brugia malayi Nuclear hormone receptor family member nhr-3 0.001 0.0037 0.0037
Onchocerca volvulus 0.0014 0.0115 0.0127
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0178 0.0288
Leishmania major cathepsin L-like protease 0.0064 0.1213 0.1462
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0037 0.0037
Schistosoma mansoni histamine h1 receptor 0.0014 0.0115 0.0115
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.1213 0.1578
Echinococcus multilocularis g protein coupled receptor 0.0014 0.0115 0.0186
Echinococcus multilocularis rhodopsin orphan GPCR 0.0014 0.0115 0.0186
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0025 0.0359 0.0359
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.005 0.0918 0.1195
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0014 0.0127 0.0127
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0025 0.0359 0.0359
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0013 0.0104 0.0105
Leishmania major cathepsin L-like protease 0.0017 0.0178 0.0098
Entamoeba histolytica dihydropyrimidine dehydrogenase, putative 0.0013 0.0104 0.0168
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0014 0.0115 0.0103
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0013 0.0104 0.0136
Echinococcus multilocularis fmrfamide receptor 0.0014 0.0115 0.0186
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0014 0.0127 0.0205
Trichomonas vaginalis CAMK family protein kinase 0.0143 0.297 0.4796
Echinococcus granulosus tm gpcr rhodopsin 0.0014 0.0115 0.0186
Echinococcus granulosus tm gpcr rhodopsin 0.0014 0.0115 0.0186
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0025 0.0359 0.0421
Echinococcus multilocularis sodium and chloride dependent glycine 0.0025 0.0359 0.0579
Onchocerca volvulus Cathepsin L homolog 0.0017 0.0178 0.023
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0025 0.0359 0.0359
Loa Loa (eye worm) hypothetical protein 0.0025 0.0359 0.0421
Trypanosoma cruzi trypanothione reductase, putative 0.005 0.0918 0.1195
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0178 0.0288
Schistosoma mansoni nuclear hormone receptor 0.001 0.0037 0.0037
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0011 0.0057 0.0092
Brugia malayi Serotonin receptor 0.046 0.995 1
Echinococcus multilocularis serotonin receptor 0.0132 0.2719 0.439
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0014 0.0115 0.0116
Onchocerca volvulus 0.0017 0.0178 0.023
Brugia malayi Serotonin receptor 0.0014 0.0115 0.0116
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0178 0.0288
Echinococcus granulosus alpha 1A adrenergic receptor 0.0014 0.0115 0.0186
Loa Loa (eye worm) hypothetical protein 0.0013 0.0104 0.0088
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0013 0.0104 0.0168
Echinococcus granulosus fmrfamide receptor 0.0014 0.0115 0.0186
Echinococcus multilocularis thyroid hormone receptor alpha 0.001 0.0037 0.0059
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0013 0.0104 0.0168
Loa Loa (eye worm) hypothetical protein 0.0014 0.0115 0.0103
Loa Loa (eye worm) hypothetical protein 0.0014 0.0115 0.0103
Echinococcus multilocularis neuropeptide receptor 0.0014 0.0115 0.0186
Schistosoma mansoni RAR-like nuclear receptor 0.001 0.0037 0.0037
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0025 0.0359 0.0877
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.005 0.0918 0.0922
Schistosoma mansoni retinoic acid receptor RXR 0.001 0.0037 0.0037
Toxoplasma gondii Erv1 / Alr family protein 0.0034 0.0564 0.1586
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0099 0.016
Onchocerca volvulus 0.0025 0.0359 0.0523
Echinococcus multilocularis allatostatin A receptor 0.0014 0.0115 0.0186
Loa Loa (eye worm) cysteine protease 0.0017 0.0178 0.0185
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0014 0.0115 0.0186
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0178 0.0288
Loa Loa (eye worm) hypothetical protein 0.0014 0.0115 0.0103
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0014 0.0127 0.0205
Loa Loa (eye worm) hypothetical protein 0.0025 0.0359 0.0421
Brugia malayi ERG2 and Sigma1 receptor like protein 0.0357 0.7682 0.7721
Onchocerca volvulus Serine\/threonine kinase homolog 0.0289 0.6193 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.0115 0.0103
Brugia malayi Cathepsin L-like precursor 0.0017 0.0178 0.0179
Loa Loa (eye worm) hypothetical protein 0.0014 0.0115 0.0103
Echinococcus granulosus neuropeptides capa receptor 0.0014 0.0115 0.0186
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0178 0.0288
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0014 0.0115 0.0115
Loa Loa (eye worm) hypothetical protein 0.0025 0.0359 0.0421
Echinococcus multilocularis neuropeptides capa receptor 0.0014 0.0115 0.0186
Trypanosoma brucei C-8 sterol isomerase, putative 0.0357 0.7682 1
Brugia malayi G protein-coupled receptor F59B2.13 0.0014 0.0115 0.0116
Mycobacterium tuberculosis Probable reductase 0.0331 0.7099 0.8958
Loa Loa (eye worm) hypothetical protein 0.0014 0.0115 0.0103
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0014 0.0115 0.0115
Echinococcus granulosus mixed lineage leukemia protein mll 0.0014 0.0127 0.0205
Loa Loa (eye worm) hypothetical protein 0.0014 0.0115 0.0103
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0289 0.6193 1
Onchocerca volvulus 0.0147 0.3041 0.488
Echinococcus multilocularis ecdysone induced protein 78C 0.001 0.0037 0.0059
Loa Loa (eye worm) hypothetical protein 0.0014 0.0115 0.0103
Loa Loa (eye worm) hypothetical protein 0.0014 0.0115 0.0103
Giardia lamblia NADH oxidase lateral transfer candidate 0.005 0.0918 0.1336
Echinococcus granulosus hypothetical protein 0.0014 0.0115 0.0186
Onchocerca volvulus 0.0017 0.0178 0.023
Schistosoma mansoni opsin-like receptor 0.0014 0.0115 0.0115
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0178 0.0288
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0013 0.0104 0.0168
Trichomonas vaginalis CAMK family protein kinase 0.0289 0.6193 1
Schistosoma mansoni amine GPCR 0.0014 0.0115 0.0115
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0014 0.0115 0.0186
Trypanosoma cruzi cysteine peptidase, putative 0.0064 0.1213 0.1578
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0014 0.0115 0.0186
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0037 0.0059
Brugia malayi glutamate synthase 0.0013 0.0104 0.0105
Brugia malayi photoreceptor-specific nuclear receptor 0.001 0.0037 0.0037
Toxoplasma gondii Erv1 / Alr family protein 0.0034 0.0564 0.1586
Schistosoma mansoni sulfide quinone reductase 0.0013 0.0104 0.0104
Brugia malayi hypothetical protein 0.0025 0.0359 0.0361
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0178 0.0288
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0099 0.016
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0013 0.0099 0.016
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0018 0.0205 0.0331
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.0025 0.0359 0.3129
Loa Loa (eye worm) TYRA-2 protein 0.0014 0.0115 0.0103
Schistosoma mansoni myosin xvIII 0.0014 0.0115 0.0115
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.001 0.0037 0.0059
Trichomonas vaginalis helicase, putative 0.0013 0.0099 0.016
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.1213 0.1578
Echinococcus granulosus g-protein coupled receptor 0.0014 0.0115 0.0186
Echinococcus multilocularis g-protein coupled receptor 0.0014 0.0115 0.0186
Brugia malayi neuropeptide F receptor 0.0014 0.0115 0.0116
Loa Loa (eye worm) hypothetical protein 0.0014 0.0115 0.0103
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0013 0.0104 0.0168
Loa Loa (eye worm) hypothetical protein 0.0014 0.0115 0.0103
Schistosoma mansoni neuropeptide F-like receptor 0.0014 0.0115 0.0115
Plasmodium vivax glutathione reductase, putative 0.0145 0.3006 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0014 0.0115 0.0186
Onchocerca volvulus 0.0017 0.0178 0.023
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.1213 0.1578
Leishmania major cathepsin L-like protease 0.0017 0.0178 0.0098
Trypanosoma brucei 2,4-dienoyl-coa reductase-like protein 0.0013 0.0104 0.0136
Trypanosoma cruzi major cysteine proteinase, putative 0.005 0.0912 0.1188
Loa Loa (eye worm) hypothetical protein 0.0014 0.0115 0.0103
Schistosoma mansoni amine GPCR 0.0014 0.0115 0.0115
Schistosoma mansoni biogenic amine (5HT) receptor 0.0014 0.0115 0.0115
Echinococcus multilocularis g protein coupled receptor 0.0014 0.0115 0.0186
Plasmodium vivax hypothetical protein, conserved 0.0025 0.0359 0.1194
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.005 0.0918 0.0918
Loa Loa (eye worm) G-protein coupled receptor 0.0014 0.0115 0.0103
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0014 0.0115 0.0186
Echinococcus granulosus somatostatin receptor 0.0014 0.0115 0.0186
Echinococcus granulosus rhodopsin orphan GPCR 0.0014 0.0115 0.0186
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0367 0.7912 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0014 0.0115 0.0186
Onchocerca volvulus 0.0014 0.0115 0.0127
Echinococcus granulosus FAD linked sulfhydryl oxidase ALR 0.0034 0.0564 0.0911
Leishmania major cysteine peptidase A (CPA) 0.0017 0.0178 0.0098
Loa Loa (eye worm) hypothetical protein 0.0011 0.0057 0.0026
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0178 0.0288
Trypanosoma cruzi trypanothione reductase, putative 0.0145 0.3006 0.3912
Schistosoma mansoni amine GPCR 0.0014 0.0115 0.0115
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.001 0.0037 0.0037
Entamoeba histolytica serine/threonine protein kinase, putative 0.0289 0.6193 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.1213 0.1578
Echinococcus multilocularis sex peptide receptor 0.0014 0.0115 0.0186
Treponema pallidum NADH oxidase 0.005 0.0918 0.2769
Trypanosoma cruzi cysteine peptidase, putative 0.0064 0.1213 0.1578
Plasmodium falciparum cysteine proteinase falcipain 3 0.0017 0.0178 0.0594
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0013 0.0104 0.0168
Schistosoma mansoni glutamate synthase 0.0013 0.0104 0.0104
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0122 0.2505 0.3075
Brugia malayi Cathepsin L-like precursor 0.0011 0.0057 0.0057
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0099 0.016
Echinococcus multilocularis rhodopsin orphan GPCR 0.0014 0.0115 0.0186
Loa Loa (eye worm) serotonin transporter b 0.0147 0.3041 0.3929
Schistosoma mansoni cpg binding protein 0.0061 0.1158 0.1158
Plasmodium vivax ferrodoxin reductase, putative 0.0013 0.0104 0.0347
Schistosoma mansoni growth hormone secretagogue receptor 0.0014 0.0115 0.0115
Onchocerca volvulus 0.0017 0.0178 0.023
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.1213 0.1578
Onchocerca volvulus 0.0014 0.0115 0.0127
Plasmodium vivax thioredoxin reductase, putative 0.0145 0.3006 1
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0099 0.016
Schistosoma mansoni cpg binding protein 0.0061 0.1158 0.1158
Trypanosoma cruzi ERV/ALR sulfhydryl oxidase domain-containing protein 0.0034 0.0564 0.0735
Echinococcus multilocularis sodium and chloride dependent glycine 0.0025 0.0359 0.0579
Echinococcus multilocularis rhodopsin orphan GPCR 0.0014 0.0115 0.0186
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.005 0.0918 0.1195
Echinococcus multilocularis G-protein coupled receptor, putative 0.0014 0.0115 0.0186
Echinococcus granulosus serotonin receptor 0.0014 0.0115 0.0186
Brugia malayi sulfakinin receptor protein 0.0014 0.0115 0.0116
Trypanosoma cruzi NADH dehydrogenase, putative 0.0013 0.0104 0.0136
Loa Loa (eye worm) hypothetical protein 0.0014 0.0115 0.0103
Echinococcus granulosus allatostatin A receptor 0.0014 0.0115 0.0186
Toxoplasma gondii thioredoxin reductase 0.0145 0.3006 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0014 0.0115 0.0186
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0037 0.0059
Trypanosoma cruzi hypothetical protein, conserved 0.0013 0.0104 0.0136
Loa Loa (eye worm) hypothetical protein 0.0014 0.0115 0.0103
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0017 0.0178 0.0288
Brugia malayi Thioredoxin reductase 0.0145 0.3006 0.3021
Echinococcus multilocularis cpg binding protein 0.0061 0.1158 0.1869
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0014 0.0115 0.0115
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0017 0.0178 0.0185
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.005 0.0918 0.3388
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0099 0.016
Loa Loa (eye worm) hypothetical protein 0.0025 0.0359 0.0421
Mycobacterium ulcerans aldehyde dehydrogenase 0.0122 0.2505 1
Plasmodium falciparum ferrodoxin reductase-like protein 0.0013 0.0104 0.0347
Echinococcus granulosus neuropeptide receptor 0.0014 0.0115 0.0186
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0025 0.0359 0.0359
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0014 0.0115 0.0186
Schistosoma mansoni biogenic amine receptor 0.0014 0.0115 0.0115
Loa Loa (eye worm) hypothetical protein 0.0132 0.2719 0.3508
Loa Loa (eye worm) hepatopoietin HPO2 0.0034 0.0564 0.069
Onchocerca volvulus 0.0014 0.0115 0.0127
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0014 0.0115 0.0116
Echinococcus granulosus sodium and chloride dependent glycine 0.0025 0.0359 0.0579
Schistosoma mansoni glutamate synthase 0.0013 0.0104 0.0104
Mycobacterium ulcerans aldehyde dehydrogenase 0.0122 0.2505 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0014 0.0115 0.0115
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0014 0.0115 0.0115
Plasmodium falciparum FAD-linked sulfhydryl oxidase ERV1, putative 0.0034 0.0564 0.1878
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0014 0.0115 0.0115
Loa Loa (eye worm) vesicular acetylcholine transporter unc-17 0.0214 0.4537 0.5886
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0331 0.7099 0.8958
Onchocerca volvulus 0.0014 0.0115 0.0127
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0013 0.0104 0.0168
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.005 0.0918 0.3053
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0037 0.0037
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0037 0.0037
Onchocerca volvulus 0.0011 0.0057 0.0032
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0017 0.0178 0.0185
Trichomonas vaginalis CAMK family protein kinase 0.0289 0.6193 1
Brugia malayi G-protein coupled receptor 0.0014 0.0115 0.0116
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.001 0.0037 0.0059
Echinococcus granulosus g protein coupled receptor 0.0014 0.0115 0.0186
Echinococcus multilocularis glutamate synthase 0.0013 0.0104 0.0168
Trichomonas vaginalis CAMK family protein kinase 0.0289 0.6193 1
Loa Loa (eye worm) hypothetical protein 0.0147 0.3041 0.3929
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.005 0.0918 0.3053
Echinococcus multilocularis neuropeptides capa receptor 0.0014 0.0115 0.0186
Echinococcus granulosus cathepsin L cysteine proteinase 0.0017 0.0178 0.0288
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.005 0.0918 0.1482
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0014 0.0115 0.0127
Schistosoma mansoni amine GPCR 0.0014 0.0115 0.0115
Onchocerca volvulus 0.0014 0.0115 0.0127
Entamoeba histolytica cysteine protease, putative 0.0017 0.0178 0.0288
Onchocerca volvulus 0.0014 0.0115 0.0127
Toxoplasma gondii cathepsin CPL 0.0017 0.0178 0.0255
Brugia malayi neuropeptide F receptor 0.0014 0.0115 0.0116
Loa Loa (eye worm) hypothetical protein 0.0014 0.0115 0.0103
Treponema pallidum sodium- and chloride- dependent transporter 0.0147 0.3041 1
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0017 0.0178 0.0288
Trypanosoma cruzi cruzipain precursor, putative 0.0064 0.1213 0.1578
Toxoplasma gondii aldehyde dehydrogenase 0.0122 0.2505 0.8275
Trypanosoma cruzi 2,4-dienoyl-coa reductase fadh1, putative 0.0013 0.0104 0.0136
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0014 0.0115 0.0115
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.001 0.0037 0.0059
Schistosoma mansoni adenoreceptor 0.0014 0.0115 0.0115
Brugia malayi glutathione reductase 0.0145 0.3006 0.3021
Loa Loa (eye worm) hypothetical protein 0.0025 0.0359 0.0421
Brugia malayi Augmenter of liver regeneration 0.0034 0.0564 0.0567
Brugia malayi Steroid receptor seven-up type 2 0.001 0.0037 0.0037
Leishmania major trypanothione reductase 0.0145 0.3006 0.3829
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0017 0.0178 0.0288
Echinococcus granulosus neuropeptide Y receptor 0.0014 0.0115 0.0186
Loa Loa (eye worm) hypothetical protein 0.0014 0.0115 0.0103
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0014 0.0115 0.0115
Trichomonas vaginalis glutathione reductase, putative 0.005 0.0918 0.1482
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0014 0.0115 0.0186
Plasmodium vivax amine transporter, putative 0.0025 0.0359 0.1194
Schistosoma mansoni cathepsin F (C01 family) 0.0017 0.0178 0.0178
Brugia malayi nuclear receptor NHR-88 0.001 0.0037 0.0037
Toxoplasma gondii histone lysine methyltransferase SET1 0.011 0.2225 0.731
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.0025 0.0359 0.0579
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0289 0.6193 0.8035
Mycobacterium tuberculosis Probable dehydrogenase 0.0331 0.7099 0.8958
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.005 0.0918 0.1195
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0014 0.0115 0.0115
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0099 0.016
Brugia malayi ecdysteroid receptor 0.001 0.0037 0.0037
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0014 0.0115 0.0186
Echinococcus multilocularis neuropeptide s receptor 0.0014 0.0115 0.0186
Brugia malayi Nuclear hormone receptor family member nhr-40 0.001 0.0037 0.0037
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0014 0.0115 0.0186
Plasmodium vivax vivapain-2 0.0017 0.0178 0.0594
Brugia malayi Nuclear hormone receptor family member nhr-1 0.001 0.0037 0.0037
Loa Loa (eye worm) hypothetical protein 0.0182 0.3834 0.4966
Brugia malayi follicle stimulating hormone receptor 0.0014 0.0115 0.0116
Brugia malayi putative neuropeptide receptor 0.0014 0.0115 0.0116
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.005 0.0918 0.1482
Onchocerca volvulus 0.0017 0.0178 0.023
Brugia malayi hypothetical protein 0.0014 0.0115 0.0116
Echinococcus multilocularis FTZ F1 alpha 0.001 0.0037 0.0059
Trypanosoma brucei NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0013 0.0104 0.0136
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.001 0.0037 0.0059
Echinococcus granulosus pyridine nucleotide disulfide oxidoreductase 0.0013 0.0104 0.0168
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.0025 0.0359 0.0579
Schistosoma mansoni aldehyde dehydrogenase 0.0122 0.2505 0.2505
Loa Loa (eye worm) hypothetical protein 0.0014 0.0115 0.0103
Schistosoma mansoni thyroid hormone receptor 0.001 0.0037 0.0037
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0367 0.7912 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0014 0.0115 0.0115
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.0013 0.0104 0.0168
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0014 0.0115 0.0186
Echinococcus multilocularis cathepsin L cysteine protease 0.0017 0.0178 0.0288
Echinococcus granulosus retinoic acid receptor rxr beta a 0.001 0.0037 0.0059
Echinococcus multilocularis serotonin transporter 0.0147 0.3041 0.491
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0014 0.0115 0.0115
Echinococcus multilocularis NADPH:adrenodoxin oxidoreductase 0.0013 0.0104 0.0168
Plasmodium vivax vivapain-2 0.0017 0.0178 0.0594
Schistosoma mansoni neuropeptide f receptor 76f 0.0014 0.0115 0.0115
Plasmodium falciparum NAD(P)H-dependent glutamate synthase, putative 0.0013 0.0104 0.0347
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.001 0.0037 0.0037
Brugia malayi AKH receptor 0.0014 0.0115 0.0116
Trypanosoma cruzi polo-like protein kinase, putative 0.0289 0.6193 0.8062
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.1213 0.1578
Brugia malayi hypothetical protein 0.0014 0.0115 0.0116
Echinococcus granulosus biogenic amine 5HT receptor 0.0132 0.2719 0.439
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.005 0.0918 0.1195
Trypanosoma cruzi cysteine peptidase, putative 0.0064 0.1213 0.1578
Onchocerca volvulus 0.0014 0.0115 0.0127
Mycobacterium ulcerans flavoprotein disulfide reductase 0.005 0.0918 0.3388
Echinococcus granulosus apoptosis inducing factor 1 mitochondrial 0.0013 0.0104 0.0168
Echinococcus multilocularis g protein coupled receptor 0.0014 0.0115 0.0186
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0014 0.0115 0.0186
Brugia malayi Dopamine receptor 0.0014 0.0115 0.0116
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0014 0.0115 0.0115
Brugia malayi cathepsin L-like precursor 0.0011 0.0057 0.0057
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0331 0.7099 0.8958
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0025 0.0359 0.0361
Loa Loa (eye worm) programmed cell death 8 0.0013 0.0104 0.0088
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.1213 0.1578
Plasmodium falciparum thioredoxin reductase 0.0145 0.3006 1
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0025 0.0359 0.0359
Schistosoma mansoni hypothetical protein 0.0014 0.0115 0.0115
Trichomonas vaginalis mercuric reductase, putative 0.005 0.0918 0.1482
Brugia malayi hypothetical protein 0.0014 0.0115 0.0116
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.005 0.0918 0.3053
Echinococcus multilocularis rhodopsin orphan GPCR 0.0014 0.0115 0.0186
Echinococcus multilocularis rhodopsin orphan GPCR 0.0014 0.0115 0.0186
Brugia malayi Nuclear hormone receptor family member nhr-49 0.001 0.0037 0.0037
Brugia malayi Cathepsin L-like precursor 0.0017 0.0178 0.0179
Schistosoma mansoni hypothetical protein 0.0013 0.0104 0.0104
Schistosoma mansoni steroid hormone receptor ad4bp 0.001 0.0037 0.0037
Echinococcus granulosus serotonin transporter 0.0147 0.3041 0.491
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.005 0.0918 0.1195
Brugia malayi Cathepsin L-like precursor 0.0017 0.0178 0.0179
Echinococcus multilocularis G protein coupled receptor 139 0.0014 0.0115 0.0186
Onchocerca volvulus 0.0014 0.0115 0.0127
Onchocerca volvulus 0.0014 0.0115 0.0127
Loa Loa (eye worm) hypothetical protein 0.0025 0.0359 0.0421
Plasmodium vivax NAD(P)H-dependent glutamate synthase, putative 0.0013 0.0104 0.0347
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0025 0.0359 0.0579
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0014 0.0115 0.0103
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0178 0.0288
Trichomonas vaginalis CAMK family protein kinase 0.0143 0.297 0.4796
Echinococcus granulosus g protein coupled receptor 0.0014 0.0115 0.0186
Leishmania major cathepsin L-like protease 0.0017 0.0178 0.0098
Loa Loa (eye worm) hypothetical protein 0.0014 0.0115 0.0103
Echinococcus multilocularis orexin receptor type 2 0.0014 0.0115 0.0186
Loa Loa (eye worm) hypothetical protein 0.0014 0.0115 0.0103
Brugia malayi G-protein coupled receptor 0.0014 0.0115 0.0116
Brugia malayi Cathepsin L-like cysteine proteinase 0.0011 0.0057 0.0057
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0014 0.0115 0.0115
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.005 0.0918 0.1042
Onchocerca volvulus 0.0014 0.0115 0.0127
Brugia malayi ORL1-like opioid receptor 0.0014 0.0115 0.0116
Onchocerca volvulus 0.0014 0.0115 0.0127
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0014 0.0115 0.0115
Loa Loa (eye worm) hypothetical protein 0.0014 0.0115 0.0103
Loa Loa (eye worm) neuropeptide F receptor 0.0014 0.0115 0.0103
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0013 0.0104 0.0136
Loa Loa (eye worm) hypothetical protein 0.0014 0.0115 0.0103
Onchocerca volvulus 0.0058 0.1085 0.1703
Echinococcus granulosus neuropeptide s receptor 0.0014 0.0115 0.0186
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0178 0.0288
Trypanosoma cruzi cysteine peptidase, putative 0.0017 0.0178 0.0232
Schistosoma mansoni hypothetical protein 0.0014 0.0115 0.0115
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.005 0.0918 0.1195
Echinococcus granulosus g protein coupled receptor 0.0014 0.0115 0.0186
Onchocerca volvulus 0.0013 0.0104 0.011
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0037 0.0624 0.0627
Brugia malayi Papain family cysteine protease containing protein 0.0017 0.0178 0.0179
Echinococcus multilocularis neuropeptide receptor 0.0014 0.0115 0.0186
Schistosoma mansoni cpg binding protein 0.0058 0.1085 0.1085
Schistosoma mansoni sodium/chloride dependent transporter 0.0026 0.038 0.038
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0018 0.0205 0.0331
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0011 0.0057 0.0092
Echinococcus granulosus cpg binding protein 0.0061 0.1158 0.1869
Schistosoma mansoni neuropeptide F-like receptor 0.0014 0.0115 0.0115
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0014 0.0115 0.0116
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0025 0.0359 0.0361
Onchocerca volvulus 0.0025 0.0359 0.0523
Brugia malayi hypothetical protein 0.0014 0.0115 0.0116
Loa Loa (eye worm) hypothetical protein 0.0014 0.0115 0.0103
Brugia malayi serine/threonine-protein kinase plk-2 0.0289 0.6193 0.6224
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0099 0.016
Brugia malayi Dopamine receptor protein 1 0.0014 0.0115 0.0116
Schistosoma mansoni disulfide oxidoreductase 0.0013 0.0104 0.0104
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0013 0.0104 0.0136
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0014 0.0115 0.0116
Brugia malayi F/Y-rich N-terminus family protein 0.0018 0.02 0.0201
Echinococcus multilocularis sulfide:quinone oxidoreductase 0.0013 0.0104 0.0168
Brugia malayi Nuclear hormone receptor family member nhr-31 0.001 0.0037 0.0037
Schistosoma mansoni biogenic amine (5HT) receptor 0.0132 0.2719 0.2719
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.001 0.0037 0.0059
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0099 0.016
Onchocerca volvulus Neuropeptide F receptor homolog 0.0014 0.0115 0.0127
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.001 0.0037 0.0037
Echinococcus multilocularis neuropeptide Y receptor 0.0014 0.0115 0.0186
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0331 0.7099 0.8958
Plasmodium falciparum glutathione reductase 0.005 0.0918 0.3053
Loa Loa (eye worm) hypothetical protein 0.0014 0.0115 0.0103
Brugia malayi hypothetical protein 0.0014 0.0115 0.0116
Echinococcus granulosus G protein coupled receptor 139 0.0014 0.0115 0.0186
Brugia malayi CXXC zinc finger family protein 0.0058 0.1085 0.109
Loa Loa (eye worm) hypothetical protein 0.0014 0.0115 0.0103
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0058 0.1091 0.142
Echinococcus granulosus rhodopsin orphan GPCR 0.0014 0.0115 0.0186
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.0025 0.0359 0.0361
Echinococcus granulosus glutamate synthase 0.0013 0.0104 0.0168
Echinococcus multilocularis apoptosis inducing factor 1 mitochondrial 0.0013 0.0104 0.0168
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0037 0.0037
Onchocerca volvulus 0.0017 0.0178 0.023
Leishmania major hypothetical protein, conserved 0.0034 0.0564 0.0607
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0122 0.2505 0.4045
Loa Loa (eye worm) hypothetical protein 0.0017 0.0178 0.0185
Loa Loa (eye worm) hypothetical protein 0.0014 0.0115 0.0103
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0014 0.0115 0.0186
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0013 0.0104 0.0168
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0014 0.0115 0.0116
Brugia malayi Nuclear hormone receptor family member nhr-14 0.001 0.0037 0.0037
Brugia malayi Cathepsin L-like precursor 0.0017 0.0178 0.0179
Brugia malayi Cathepsin L-like precursor 0.0011 0.0057 0.0057
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0099 0.016
Echinococcus multilocularis neuropeptide Y receptor 0.0014 0.0115 0.0186
Schistosoma mansoni amine GPCR 0.0014 0.0115 0.0115
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.0025 0.0359 0.0579
Echinococcus granulosus sulfide:quinone oxidoreductase 0.0013 0.0104 0.0168
Loa Loa (eye worm) hypothetical protein 0.0014 0.0115 0.0103
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0014 0.0115 0.0186
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0013 0.0104 0.0168
Echinococcus granulosus 7TM GPCR rhodopsin 0.0014 0.0115 0.0186
Echinococcus granulosus dro:myosuppressin receptor 0.0014 0.0115 0.0186
Echinococcus multilocularis pyridine nucleotide disulfide oxidoreductase 0.0013 0.0104 0.0168
Onchocerca volvulus Cathepsin L homolog 0.0017 0.0178 0.023
Echinococcus granulosus FTZ F1 alpha 0.001 0.0037 0.0059
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0178 0.0288
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0025 0.0359 0.0877
Entamoeba histolytica disulphide oxidoreductase, putative 0.0013 0.0104 0.0168
Brugia malayi hypothetical protein 0.0014 0.0115 0.0116
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.001 0.0037 0.0059
Trypanosoma cruzi 2,4-dienoyl-coa reductase-like protein, putative 0.0013 0.0104 0.0136
Loa Loa (eye worm) norepinephrine transporter 0.0147 0.3041 0.3929
Echinococcus granulosus cathepsin l cysteine peptidase 0.0017 0.0178 0.0288
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0037 0.0059
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0178 0.0288
Loa Loa (eye worm) hypothetical protein 0.0011 0.0057 0.0026
Schistosoma mansoni glutamate synthase 0.0013 0.0104 0.0104
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0178 0.0288
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0178 0.0288
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0147 0.3041 0.3056
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0178 0.0288
Onchocerca volvulus Cathepsin F homolog 0.0017 0.0178 0.023
Echinococcus multilocularis rhodopsin orphan GPCR 0.0014 0.0115 0.0186
Echinococcus multilocularis dro:myosuppressin receptor 0.0014 0.0115 0.0186
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0014 0.0115 0.0115
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.1213 0.1578
Echinococcus granulosus cathepsin l1 0.0017 0.0178 0.0288
Brugia malayi vesicular acetylcholine transporter unc-17 0.0214 0.4537 0.4559
Brugia malayi larval opioid receptor 0.0014 0.0115 0.0116
Loa Loa (eye worm) hypothetical protein 0.0014 0.0115 0.0103
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.1213 0.1578
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0037 0.0037
Schistosoma mansoni neuropeptide receptor 0.0014 0.0115 0.0115
Leishmania major C-8 sterol isomerase-like protein 0.0357 0.7682 1
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0099 0.016
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0178 0.0288
Schistosoma mansoni opsin-like receptor 0.0014 0.0115 0.0115
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0147 0.3041 0.3041
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0014 0.0115 0.0103
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0013 0.0104 0.0136
Loa Loa (eye worm) fibroinase 0.0017 0.0178 0.0185
Leishmania major dihydrolipoamide dehydrogenase, putative 0.005 0.0918 0.1073
Trichomonas vaginalis CAMK family protein kinase 0.0289 0.6193 1
Loa Loa (eye worm) thioredoxin reductase 0.0145 0.3006 0.3883
Brugia malayi RE15519p 0.0014 0.0115 0.0116
Leishmania major cathepsin L-like protease 0.0017 0.0178 0.0098
Trichomonas vaginalis CAMK family protein kinase 0.0289 0.6193 1
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0099 0.016
Brugia malayi Cathepsin L-like precursor 0.0017 0.0178 0.0179
Echinococcus granulosus peptide allatostatin:somatostatin 0.0014 0.0115 0.0186
Loa Loa (eye worm) histone methyltransferase 0.0018 0.0205 0.022
Loa Loa (eye worm) solute carrier family 6 member 4 0.0147 0.3041 0.3929
Onchocerca volvulus 0.0014 0.0115 0.0127
Entamoeba histolytica cysteine proteinase, putative 0.0011 0.0057 0.0092
Toxoplasma gondii hypothetical protein 0.0025 0.0359 0.0877
Echinococcus multilocularis thioredoxin glutathione reductase 0.0145 0.3006 0.4853
Loa Loa (eye worm) hypothetical protein 0.0014 0.0115 0.0103
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0367 0.7912 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0178 0.0288
Onchocerca volvulus 0.0017 0.0178 0.023
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0013 0.0104 0.0168
Entamoeba histolytica thioredoxin reductase, putative 0.0013 0.0104 0.0168
Schistosoma mansoni serine/threonine protein kinase 0.0289 0.6193 0.6193
Loa Loa (eye worm) hypothetical protein 0.0025 0.0359 0.0421
Schistosoma mansoni hypothetical protein 0.0014 0.0115 0.0115
Brugia malayi NADPH:adrenodoxin oxidoreductase, mitochondrial precursor 0.0013 0.0104 0.0105
Loa Loa (eye worm) hypothetical protein 0.0014 0.0115 0.0103
Schistosoma mansoni vesicular acetylcholine transporter 0.0214 0.4537 0.4537
Trypanosoma brucei polo-like protein kinase 0.0289 0.6193 0.8062
Schistosoma mansoni cathepsin F (C01 family) 0.0011 0.0057 0.0057
Brugia malayi hypothetical protein 0.0014 0.0115 0.0116
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0123 0.2514 0.2514
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0099 0.016
Loa Loa (eye worm) hypothetical protein 0.0014 0.0115 0.0103
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0014 0.0115 0.0186
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.005 0.0918 0.1195
Echinococcus multilocularis cathepsin L cysteine protease 0.0017 0.0178 0.0288
Echinococcus multilocularis cysteine protease 0.0017 0.0178 0.0288
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0178 0.0288
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0178 0.0288
Echinococcus multilocularis cysteine protease 0.0017 0.0178 0.0288
Leishmania major cathepsin L-like protease 0.0017 0.0178 0.0098
Entamoeba histolytica cysteine proteinase, putative 0.0017 0.0178 0.0288
Schistosoma mansoni aldehyde dehydrogenase 0.0122 0.2505 0.2505
Loa Loa (eye worm) hypothetical protein 0.0014 0.0115 0.0103
Echinococcus granulosus orexin receptor type 2 0.0014 0.0115 0.0186
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0178 0.0288
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0014 0.0115 0.0115
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0014 0.0115 0.0186
Schistosoma mansoni thyroid hormone receptor 0.001 0.0037 0.0037
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0014 0.0115 0.0103
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0037 0.0624 0.0627
Trypanosoma cruzi NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0013 0.0104 0.0136
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0014 0.0115 0.0186
Trypanosoma cruzi NADH dehydrogenase, putative 0.0013 0.0104 0.0136
Echinococcus multilocularis FAD linked sulfhydryl oxidase ALR 0.0034 0.0564 0.0911
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.1213 0.1578
Entamoeba histolytica NAD(FAD)-dependent dehydrogenase, putative 0.0013 0.0104 0.0168
Entamoeba histolytica cysteine proteinase, putative 0.0017 0.0178 0.0288
Plasmodium falciparum thioredoxin reductase 0.005 0.0918 0.3053
Plasmodium falciparum glutathione reductase 0.0145 0.3006 1
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0014 0.0115 0.0115
Leishmania major cathepsin L-like protease 0.0064 0.1213 0.1462
Echinococcus granulosus tachykinin peptides receptor 99D 0.0014 0.0115 0.0186
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0289 0.6193 0.8053
Echinococcus granulosus sodium and chloride dependent glycine 0.0025 0.0359 0.0579
Plasmodium vivax FAD-linked sulfhydryl oxidase ERV1, putative 0.0034 0.0564 0.1878
Echinococcus multilocularis serotonin receptor 0.0132 0.2719 0.439
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0014 0.0115 0.0186
Onchocerca volvulus 0.0014 0.0115 0.0127
Brugia malayi Cathepsin L-like precursor 0.0017 0.0178 0.0179
Leishmania major dihydrolipoamide dehydrogenase, putative 0.005 0.0918 0.1073
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0014 0.0115 0.0115
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0013 0.0104 0.0105
Echinococcus granulosus rhodopsin orphan GPCR 0.0014 0.0115 0.0186
Brugia malayi hypothetical protein 0.0014 0.0115 0.0116
Schistosoma mansoni kinase 0.0147 0.3054 0.3054
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0013 0.0104 0.0168
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0178 0.0288
Trichomonas vaginalis glutamate synthase, putative 0.0013 0.0104 0.0168
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0025 0.0359 0.0421
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0331 0.7099 0.8958
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.005 0.0918 1
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0025 0.0359 0.0361
Schistosoma mansoni biogenic amine receptor 0.0014 0.0115 0.0115
Schistosoma mansoni sodium-dependent amino acid transporter 0.0025 0.0359 0.0359
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.001 0.0037 0.0037
Schistosoma mansoni sulfide quinone reductase 0.0013 0.0104 0.0104
Loa Loa (eye worm) hypothetical protein 0.0014 0.0115 0.0103
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.0037 0.0037
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.0025 0.0359 0.0579
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.001 0.0037 0.0059
Trichomonas vaginalis glutamate synthase, putative 0.0013 0.0104 0.0168
Echinococcus granulosus biogenic amine 5HT receptor 0.0014 0.0115 0.0186
Loa Loa (eye worm) glutathione reductase 0.0145 0.3006 0.3883
Leishmania major cathepsin L-like protease 0.0064 0.1213 0.1462
Loa Loa (eye worm) hypothetical protein 0.0014 0.0115 0.0103
Trichomonas vaginalis CAMK family protein kinase 0.0289 0.6193 1
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0025 0.0359 0.0359
Loa Loa (eye worm) hypothetical protein 0.0014 0.0115 0.0103
Loa Loa (eye worm) hypothetical protein 0.0014 0.0115 0.0103
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 0.0034 0.0564 0.0735
Mycobacterium tuberculosis Probable oxidoreductase 0.0367 0.7912 1
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0013 0.0104 0.0168
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0014 0.0115 0.0186
Trichomonas vaginalis apoptosis inducing factor, putative 0.0013 0.0104 0.0168
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0014 0.0115 0.0115
Echinococcus granulosus 7tm_1 domain containing protein 0.0014 0.0115 0.0186
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0025 0.0359 0.0359
Mycobacterium ulcerans aldehyde dehydrogenase 0.0122 0.2505 1
Onchocerca volvulus 0.0014 0.0115 0.0127
Loa Loa (eye worm) hypothetical protein 0.0014 0.0115 0.0103
Loa Loa (eye worm) hypothetical protein 0.0014 0.0115 0.0103
Brugia malayi Nuclear hormone receptor family member nhr-41 0.001 0.0037 0.0037
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0013 0.0104 0.0168
Echinococcus granulosus cathepsin l1 0.0011 0.0057 0.0092
Loa Loa (eye worm) cytochrome P450 family protein 0.0024 0.0335 0.039
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0014 0.0115 0.0115
Echinococcus granulosus neuropeptide receptor 0.0014 0.0115 0.0186
Echinococcus multilocularis somatostatin receptor 0.0014 0.0115 0.0186
Loa Loa (eye worm) CXXC zinc finger family protein 0.0058 0.1085 0.1371
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0014 0.0115 0.0103
Loa Loa (eye worm) hypothetical protein 0.0014 0.0115 0.0103
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0014 0.0127 0.0205
Echinococcus granulosus vesicular acetylcholine transporter 0.0214 0.4537 0.7325
Trypanosoma brucei trypanothione reductase 0.0145 0.3006 0.3912
Schistosoma mansoni neuropeptide receptor 0.0014 0.0115 0.0115
Echinococcus granulosus tm gpcr rhodopsin 0.0014 0.0115 0.0186
Loa Loa (eye worm) melatonin receptor type 1A 0.0014 0.0115 0.0103
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0014 0.0115 0.0186
Loa Loa (eye worm) hypothetical protein 0.0132 0.2719 0.3508
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0017 0.0178 0.0594
Echinococcus granulosus neuropeptide Y receptor 0.0014 0.0115 0.0186
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.005 0.0918 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.0115 0.0103
Schistosoma mansoni alpha-1 adrenergic receptor 0.0014 0.0115 0.0115
Echinococcus granulosus sex peptide receptor 0.0014 0.0115 0.0186
Entamoeba histolytica pyridine nucleotide-disulfide oxidoreductase family protein 0.0013 0.0104 0.0168
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0025 0.0359 0.0359
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.005 0.0918 0.3388
Loa Loa (eye worm) hypothetical protein 0.0147 0.3041 0.3929
Echinococcus multilocularis rhodopsin orphan GPCR 0.0014 0.0115 0.0186
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.005 0.0918 0.3053
Echinococcus multilocularis neuropeptide receptor A26 0.0014 0.0115 0.0186
Schistosoma mansoni hypothetical protein 0.0014 0.0115 0.0115
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.005 0.0918 0.1195
Trypanosoma cruzi hypothetical protein, conserved 0.0013 0.0104 0.0136
Echinococcus multilocularis neuropeptide FF receptor 2 0.0014 0.0115 0.0186
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.005 0.0918 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.0115 0.0103
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.005 0.0918 0.1195
Schistosoma mansoni sodium/chloride dependent transporter 0.0025 0.0359 0.0359
Onchocerca volvulus 0.0014 0.0115 0.0127
Onchocerca volvulus Vesicular acetylcholine transporter homolog 0.0214 0.4537 0.7309
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.005 0.0918 0.1195
Brugia malayi Tachykinin-like peptides receptor 99D 0.0014 0.0115 0.0116
Brugia malayi putative neuropeptide receptor NPR1 0.0014 0.0115 0.0116
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0099 0.016
Echinococcus multilocularis vesicular acetylcholine transporter 0.0214 0.4537 0.7325
Toxoplasma gondii hypothetical protein 0.0025 0.0359 0.0877
Loa Loa (eye worm) ctsf protein 0.0017 0.0178 0.0185
Onchocerca volvulus 0.0025 0.0359 0.0523
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0014 0.0115 0.0186
Loa Loa (eye worm) hypothetical protein 0.0014 0.0115 0.0103
Loa Loa (eye worm) G-protein coupled receptor 0.0014 0.0115 0.0103

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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