Detailed information for compound 916536

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 492.567 | Formula: C25H20N2O5S2
  • H donors: 3 H acceptors: 4 LogP: 5.06 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(CN1C(=S)S/C(=C\c2ccc(c(c2)O)O)/C1=O)Nc1ccc(cc1)Oc1ccc(cc1)C
  • InChi: 1S/C25H20N2O5S2/c1-15-2-7-18(8-3-15)32-19-9-5-17(6-10-19)26-23(30)14-27-24(31)22(34-25(27)33)13-16-4-11-20(28)21(29)12-16/h2-13,28-29H,14H2,1H3,(H,26,30)/b22-13-
  • InChiKey: NDEWWTFWHOMPMV-XKZIYDEJSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Thermus thermophilus Malate dehydrogenase Starlite/ChEMBL References
Escherichia coli 1-deoxy-D-xylulose 5-phosphate reductoisomerase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni malate dehydrogenase Get druggable targets OG5_127410 All targets in OG5_127410
Babesia bovis 1-deoxy-D-xylulose 5-phosphate reductoisomerase family protein Get druggable targets OG5_130462 All targets in OG5_130462
Trichomonas vaginalis malate dehydrogenase, putative Get druggable targets OG5_127410 All targets in OG5_127410
Leishmania braziliensis cytosolic malate dehydrogenase Get druggable targets OG5_127410 All targets in OG5_127410
Entamoeba histolytica malate dehydrogenase,cytoplasmic, putative Get druggable targets OG5_127410 All targets in OG5_127410
Treponema pallidum 1-deoxy-D-xylulose 5-phosphate reductoisomerase Get druggable targets OG5_130462 All targets in OG5_130462
Trypanosoma brucei gambiense cytosolic malate dehydrogenase, putative Get druggable targets OG5_127410 All targets in OG5_127410
Brugia malayi Malate dehydrogenase, cytoplasmic Get druggable targets OG5_127410 All targets in OG5_127410
Echinococcus granulosus cytosolic malate dehydrogenase Get druggable targets OG5_127410 All targets in OG5_127410
Mycobacterium ulcerans 1-deoxy-D-xylulose 5-phosphate reductoisomerase Get druggable targets OG5_130462 All targets in OG5_130462
Trichomonas vaginalis malate dehydrogenase, putative Get druggable targets OG5_127410 All targets in OG5_127410
Trichomonas vaginalis malate dehydrogenase, putative Get druggable targets OG5_127410 All targets in OG5_127410
Chlamydia trachomatis 1-deoxy-D-xylulose 5-phosphate reductoisomerase Get druggable targets OG5_130462 All targets in OG5_130462
Trichomonas vaginalis malate and lactate dehydrogenase, putative Get druggable targets OG5_127410 All targets in OG5_127410
Leishmania mexicana cytosolic malate dehydrogenase, putative Get druggable targets OG5_127410 All targets in OG5_127410
Echinococcus granulosus cytosolic malate dehydrogenase Get druggable targets OG5_127410 All targets in OG5_127410
Trichomonas vaginalis malate dehydrogenase, putative Get druggable targets OG5_127410 All targets in OG5_127410
Plasmodium knowlesi 1-deoxy-D-xylulose 5-phosphate reductoisomerase, putative Get druggable targets OG5_130462 All targets in OG5_130462
Toxoplasma gondii 1-deoxy-D-xylulose 5-phosphate reductoisomerase, putative Get druggable targets OG5_130462 All targets in OG5_130462
Trichomonas vaginalis malate dehydrogenase, putative Get druggable targets OG5_127410 All targets in OG5_127410
Trichomonas vaginalis malate and lactate dehydrogenase, putative Get druggable targets OG5_127410 All targets in OG5_127410
Neospora caninum 1-deoxy-D-xylulose 5-phosphate reductoisomerase, putative Get druggable targets OG5_130462 All targets in OG5_130462
Echinococcus multilocularis cytosolic malate dehydrogenase Get druggable targets OG5_127410 All targets in OG5_127410
Trichomonas vaginalis malate dehydrogenase, putative Get druggable targets OG5_127410 All targets in OG5_127410
Plasmodium falciparum 1-deoxy-D-xylulose 5-phosphate reductoisomerase Get druggable targets OG5_130462 All targets in OG5_130462
Leishmania infantum cytosolic malate dehydrogenase Get druggable targets OG5_127410 All targets in OG5_127410
Leishmania donovani cytosolic malate dehydrogenase Get druggable targets OG5_127410 All targets in OG5_127410
Theileria parva 1-deoxy-D-xylulose 5-phosphate reductoisomerase, putative Get druggable targets OG5_130462 All targets in OG5_130462
Chlamydia trachomatis malate dehydrogenase Get druggable targets OG5_127410 All targets in OG5_127410
Trypanosoma brucei cytosolic malate dehydrogenase Get druggable targets OG5_127410 All targets in OG5_127410
Mycobacterium tuberculosis Probable malate dehydrogenase Mdh Get druggable targets OG5_127410 All targets in OG5_127410
Trypanosoma congolense cytosolic malate dehydrogenase Get druggable targets OG5_127410 All targets in OG5_127410
Schistosoma japonicum ko:K00026 malate dehydrogenase [EC1.1.1.37B], putative Get druggable targets OG5_127410 All targets in OG5_127410
Wolbachia endosymbiont of Brugia malayi 1-deoxy-D-xylulose 5-phosphate reductoisomerase Get druggable targets OG5_130462 All targets in OG5_130462
Trichomonas vaginalis malate dehydrogenase, putative Get druggable targets OG5_127410 All targets in OG5_127410
Loa Loa (eye worm) malate dehydrogenase Get druggable targets OG5_127410 All targets in OG5_127410
Entamoeba histolytica malate dehydrogenase, putative Get druggable targets OG5_127410 All targets in OG5_127410
Mycobacterium leprae PROBABLE MALATE DEHYDROGENASE MDH Get druggable targets OG5_127410 All targets in OG5_127410
Trypanosoma cruzi cytosolic malate dehydrogenase, putative Get druggable targets OG5_127410 All targets in OG5_127410
Trichomonas vaginalis malate dehydrogenase, putative Get druggable targets OG5_127410 All targets in OG5_127410
Mycobacterium leprae PROBABLE 1-DEOXY-D-XYLULOSE 5-PHOSPHATE REDUCTOISOMERASE DXR (DXP REDUCTOISOMERASE) (1-DEOXYXYLULOSE-5-PHOSPHATE REDUCTOISOMERAS Get druggable targets OG5_130462 All targets in OG5_130462
Trypanosoma cruzi cytosolic malate dehydrogenase, putative Get druggable targets OG5_127410 All targets in OG5_127410
Mycobacterium ulcerans malate dehydrogenase Get druggable targets OG5_127410 All targets in OG5_127410
Trichomonas vaginalis malate dehydrogenase, putative Get druggable targets OG5_127410 All targets in OG5_127410
Trichomonas vaginalis malate and lactate dehydrogenase, putative Get druggable targets OG5_127410 All targets in OG5_127410
Schistosoma mansoni malate dehydrogenase Get druggable targets OG5_127410 All targets in OG5_127410
Giardia lamblia Malate dehydrogenase Get druggable targets OG5_127410 All targets in OG5_127410
Plasmodium berghei 1-deoxy-D-xylulose 5-phosphate reductoisomerase, putative Get druggable targets OG5_130462 All targets in OG5_130462
Leishmania major cytosolic malate dehydrogenase Get druggable targets OG5_127410 All targets in OG5_127410
Trichomonas vaginalis malate dehydrogenase, putative Get druggable targets OG5_127410 All targets in OG5_127410
Echinococcus multilocularis cytosolic malate dehydrogenase Get druggable targets OG5_127410 All targets in OG5_127410
Trichomonas vaginalis malate dehydrogenase, putative Get druggable targets OG5_127410 All targets in OG5_127410
Plasmodium vivax 1-deoxy-D-xylulose 5-phosphate reductoisomerase, putative Get druggable targets OG5_130462 All targets in OG5_130462
Mycobacterium tuberculosis Probable 1-deoxy-D-xylulose 5-phosphate reductoisomerase Dxr (DXP reductoisomerase) (1-deoxyxylulose-5-phosphate reductoisomeras Get druggable targets OG5_130462 All targets in OG5_130462
Trichomonas vaginalis malate and lactate dehydrogenase, putative Get druggable targets OG5_127410 All targets in OG5_127410
Trichomonas vaginalis malate dehydrogenase, putative Get druggable targets OG5_127410 All targets in OG5_127410
Plasmodium yoelii 1-deoxy-D-xylulose 5-phosphate reductoisomerase Get druggable targets OG5_130462 All targets in OG5_130462
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Entamoeba histolytica malate dehydrogenase, putative Malate dehydrogenase   327 aa 315 aa 43.5 %
Onchocerca volvulus Malate dehydrogenase   327 aa 341 aa 22.6 %
Echinococcus multilocularis malate dehydrogenase 1b Malate dehydrogenase   327 aa 353 aa 23.8 %
Schistosoma mansoni malate dehydrogenase Malate dehydrogenase   327 aa 367 aa 21.8 %
Echinococcus granulosus malate dehydrogenase 1b Malate dehydrogenase   327 aa 364 aa 24.2 %
Brugia malayi lactate dehydrogenase. Malate dehydrogenase   327 aa 345 aa 22.6 %
Onchocerca volvulus Malate dehydrogenase   327 aa 322 aa 53.7 %
Loa Loa (eye worm) hypothetical protein Malate dehydrogenase   327 aa 342 aa 21.6 %
Echinococcus multilocularis L lactate dehydrogenase B chain Malate dehydrogenase   327 aa 267 aa 22.1 %
Echinococcus granulosus L lactate dehydrogenase B chain Malate dehydrogenase   327 aa 267 aa 22.1 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0012 0.0011 0.0012
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0023 0.0223 0.0246
Trichomonas vaginalis chromobox protein, putative 0.0026 0.028 0.034
Schistosoma mansoni steroid dehydrogenase 0.0017 0.0117 0.0117
Echinococcus granulosus Polycystic kidney disease protein 0.0044 0.065 0.0716
Brugia malayi Retinol dehydrogenase 12 0.0017 0.0117 0.0247
Echinococcus granulosus chromobox protein 2 0.0026 0.028 0.0309
Plasmodium vivax multidomain scavenger receptor, putative 0.0044 0.065 0.0539
Trichomonas vaginalis malate dehydrogenase, putative 0.0051 0.0784 0.1389
Trypanosoma cruzi malate dehydrogenase, putative 0.0022 0.0199 0.0192
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.041 0.0611
Echinococcus multilocularis retinol dehydrogenase 11 0.0017 0.0117 0.0129
Brugia malayi Nuclear hormone receptor-like 1 0.0023 0.0223 0.0494
Plasmodium vivax lactate/malate dehydrogenase, putative 0.0022 0.0199 0.0083
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0032 0.041 0.0761
Schistosoma mansoni thyroid hormone receptor 0.0023 0.0223 0.0234
Trichomonas vaginalis malate dehydrogenase, putative 0.0022 0.0199 0.017
Leishmania major malate dehydrogenase 0.0022 0.0199 0.0192
Mycobacterium ulcerans hypothetical protein 0.0027 0.0305 0.019
Brugia malayi RNA binding protein 0.007 0.1147 0.2649
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0033 0.0428 0.0648
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.007 0.1147 0.2668
Loa Loa (eye worm) hypothetical protein 0.0012 0.0011 0.0026
Trypanosoma brucei polo-like protein kinase 0.0213 0.3968 0.9028
Brugia malayi 6-phosphofructokinase 0.012 0.2129 0.4941
Mycobacterium tuberculosis Probable 1-deoxy-D-xylulose 5-phosphate reductoisomerase Dxr (DXP reductoisomerase) (1-deoxyxylulose-5-phosphate reductoisomeras 0.0125 0.2234 0.8909
Schistosoma mansoni serine/threonine protein kinase 0.0213 0.3968 0.4366
Echinococcus granulosus chromobox protein 1 0.0157 0.2868 0.316
Schistosoma mansoni retinoic acid receptor RXR 0.0023 0.0223 0.0234
Loa Loa (eye worm) TAR-binding protein 0.007 0.1147 0.2668
Echinococcus multilocularis steroid dehydrogenase 0.0017 0.0117 0.0129
Entamoeba histolytica hypothetical protein 0.0026 0.028 0.0424
Brugia malayi dehydrogenases, short chain protein 9 0.0017 0.0117 0.0247
Plasmodium vivax 6-phosphofructokinase, putative 0.0032 0.041 0.0297
Schistosoma mansoni chromobox protein 0.0157 0.2868 0.3152
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0017 0.0117 0.0247
Brugia malayi Associated with TFs and helicases family protein 0.0026 0.028 0.0628
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0023 0.0223 0.0246
Schistosoma mansoni thyroid hormone receptor 0.0023 0.0223 0.0234
Toxoplasma gondii 6-phosphofructokinase 0.0032 0.041 0.0297
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.028 0.034
Loa Loa (eye worm) hypothetical protein 0.0026 0.028 0.0653
Loa Loa (eye worm) helicase 0.0026 0.028 0.0653
Loa Loa (eye worm) phosphofructokinase 0.012 0.2129 0.4954
Echinococcus multilocularis transient receptor potential cation channel 0.0017 0.0117 0.0129
Trypanosoma brucei malate dehydrogenase-related 0.0022 0.0199 0.0192
Trichomonas vaginalis phosphofructokinase, putative 0.012 0.2129 0.4189
Loa Loa (eye worm) hypothetical protein 0.0023 0.0223 0.0519
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0023 0.0223 0.0519
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0023 0.0223 0.0494
Toxoplasma gondii chromodomain helicase DNA binding protein CHD1/SWI2/SNF2 0.0026 0.028 0.0165
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0023 0.0223 0.0234
Schistosoma mansoni short chain dehydrogenase 0.0017 0.0117 0.0117
Brugia malayi Valyl-tRNA synthetase 0.0026 0.028 0.0628
Trichomonas vaginalis malate and lactate dehydrogenase, putative 0.0051 0.0784 0.1389
Loa Loa (eye worm) hypothetical protein 0.0022 0.0199 0.0463
Mycobacterium tuberculosis Probable malate dehydrogenase Mdh 0.0051 0.0784 0.2807
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0213 0.3968 0.9234
Brugia malayi phosphofructokinase 0.012 0.2129 0.4941
Schistosoma mansoni rab6-interacting 0.0044 0.065 0.0704
Brugia malayi ecdysteroid receptor 0.0023 0.0223 0.0494
Trypanosoma brucei glycosomal malate dehydrogenase 0.0022 0.0199 0.0192
Echinococcus granulosus tar DNA binding protein 0.007 0.1147 0.1264
Echinococcus multilocularis lactate dehydrogenase a 0.0022 0.0199 0.0219
Schistosoma mansoni polycystin 1-related 0.0044 0.065 0.0704
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.0027 0.0305 0.019
Schistosoma mansoni tar DNA-binding protein 0.007 0.1147 0.1253
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0023 0.0223 0.0234
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0023 0.0223 0.0519
Brugia malayi Malate dehydrogenase, cytoplasmic 0.0051 0.0784 0.1803
Brugia malayi Dehydrogenases, short chain protein 30 0.0017 0.0117 0.0247
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0023 0.0223 0.0234
Trichomonas vaginalis CAMK family protein kinase 0.0213 0.3968 0.8018
Trypanosoma cruzi glycosomal malate dehydrogenase, putative 0.0022 0.0199 0.0192
Trichomonas vaginalis malate dehydrogenase, putative 0.0051 0.0784 0.1389
Giardia lamblia Malate dehydrogenase 0.0051 0.0784 0.1732
Echinococcus multilocularis estradiol 17 beta dehydrogenase 12 0.0017 0.0117 0.0129
Echinococcus multilocularis Chromobox protein 3 0.0026 0.028 0.0309
Schistosoma mansoni cpg binding protein 0.0035 0.0464 0.05
Leishmania major malate dehydrogenase, putative 0.0022 0.0199 0.0192
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0026 0.028 0.0297
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.041 0.0611
Trichomonas vaginalis chromobox protein, putative 0.0095 0.164 0.317
Echinococcus granulosus cpg binding protein 0.0035 0.0464 0.0512
Echinococcus granulosus carbonyl reductase 1 0.0017 0.0117 0.0129
Loa Loa (eye worm) hypothetical protein 0.0012 0.0011 0.0026
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0053 0.0814 0.0897
Echinococcus multilocularis retinol dehydrogenase 13 0.0017 0.0117 0.0129
Schistosoma mansoni cpg binding protein 0.0035 0.0464 0.05
Trichomonas vaginalis conserved hypothetical protein 0.003 0.036 0.0505
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0213 0.3968 0.9028
Brugia malayi photoreceptor-specific nuclear receptor 0.0023 0.0223 0.0494
Echinococcus granulosus geminin 0.0196 0.3627 0.3997
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0017 0.0117 0.0247
Loa Loa (eye worm) hypothetical protein 0.0026 0.028 0.0653
Brugia malayi CHD4 protein 0.0028 0.0318 0.0715
Schistosoma mansoni RAR-like nuclear receptor 0.0023 0.0223 0.0234
Trichomonas vaginalis malate dehydrogenase, putative 0.0051 0.0784 0.1389
Loa Loa (eye worm) doublecortin family protein 0.0044 0.065 0.1512
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0026 0.028 0.0297
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0023 0.0223 0.0246
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0033 0.0428 0.0648
Trichomonas vaginalis chromobox protein, putative 0.0026 0.028 0.034
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0023 0.0223 0.0246
Loa Loa (eye worm) hypothetical protein 0.0023 0.0223 0.0519
Trypanosoma cruzi mitochondrial malate dehydrogenase, putative 0.0022 0.0199 0.0192
Echinococcus granulosus steroid dehydrogenase 0.0017 0.0117 0.0129
Brugia malayi nuclear receptor NHR-88 0.0023 0.0223 0.0494
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0017 0.0117 0.0247
Echinococcus multilocularis dnaJ subfamily B 0.0473 0.9073 1
Loa Loa (eye worm) hypothetical protein 0.0023 0.0223 0.0519
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0023 0.0223 0.0494
Trichomonas vaginalis conserved hypothetical protein 0.0062 0.1002 0.1842
Plasmodium vivax malate dehydrogenase, putative 0.0022 0.0199 0.0083
Echinococcus granulosus lactate dehydrogenase protein 0.0022 0.0199 0.0219
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.028 0.034
Trichomonas vaginalis malate dehydrogenase, putative 0.0051 0.0784 0.1389
Loa Loa (eye worm) hypothetical protein 0.0017 0.0117 0.0273
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0023 0.0223 0.0234
Brugia malayi dehydrogenases, short chain protein 2 0.0017 0.0117 0.0247
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0053 0.0814 0.1895
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0017 0.0117 0.0247
Brugia malayi hypothetical protein 0.0026 0.028 0.0628
Brugia malayi D-beta-hydroxybutyrate dehydrogenase, mitochondrial precursor 0.0017 0.0117 0.0247
Loa Loa (eye worm) hypothetical protein 0.0173 0.317 0.7378
Echinococcus granulosus chromobox protein 1 0.0157 0.2868 0.316
Leishmania major 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0027 0.0305 0.044
Trichomonas vaginalis malate and lactate dehydrogenase, putative 0.0051 0.0784 0.1389
Schistosoma mansoni malate dehydrogenase 0.0051 0.0784 0.0853
Entamoeba histolytica malate dehydrogenase, putative 0.0022 0.0199 0.0212
Mycobacterium tuberculosis Conserved protein 0.0027 0.0305 0.0791
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0034 0.0435 0.048
Echinococcus multilocularis ecdysone induced protein 78C 0.0023 0.0223 0.0246
Schistosoma mansoni aldehyde dehydrogenase 0.0137 0.247 0.2713
Echinococcus granulosus citrate lyase subunit beta protein 0.0027 0.0305 0.0336
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.003 0.036 0.0505
Schistosoma mansoni short-chain dehydrogenase/reductase 0.0017 0.0117 0.0117
Trichomonas vaginalis malate and lactate dehydrogenase, putative 0.0051 0.0784 0.1389
Schistosoma mansoni lipoxygenase 0.0125 0.2225 0.2443
Echinococcus granulosus lactate dehydrogenase a 0.0022 0.0199 0.0219
Mycobacterium ulcerans aldehyde dehydrogenase 0.0137 0.247 0.2381
Plasmodium falciparum L-lactate dehydrogenase 0.0022 0.0199 0.0083
Brugia malayi Dehydrogenases, short chain protein 2 0.0017 0.0117 0.0247
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0053 0.0814 0.0886
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0026 0.028 0.0424
Plasmodium vivax 6-phosphofructokinase, putative 0.0032 0.041 0.0297
Giardia lamblia Kinase, PLK 0.0213 0.3968 1
Echinococcus multilocularis 6 phosphofructokinase 0.012 0.2129 0.2346
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0053 0.0814 0.0886
Schistosoma mansoni carbonyl reductase 0.0017 0.0117 0.0117
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0026 0.028 0.0424
Loa Loa (eye worm) hypothetical protein 0.0044 0.065 0.1512
Brugia malayi Heterochromatin protein 1 0.0157 0.2868 0.6664
Loa Loa (eye worm) heterochromatin protein 1 0.0157 0.2868 0.6673
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0023 0.0223 0.0494
Trichomonas vaginalis conserved hypothetical protein 0.0088 0.1508 0.2896
Schistosoma mansoni short chain dehydrogenase 0.0017 0.0117 0.0117
Loa Loa (eye worm) hypothetical protein 0.0012 0.0011 0.0026
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0138 0.2493 1
Entamoeba histolytica malate dehydrogenase,cytoplasmic, putative 0.0051 0.0784 0.1732
Schistosoma mansoni steroid dehydrogenase 0.0017 0.0117 0.0117
Trypanosoma cruzi glycosomal malate dehydrogenase, putative 0.0022 0.0199 0.0192
Trichomonas vaginalis conserved hypothetical protein 0.0062 0.1002 0.1842
Echinococcus granulosus lipoxygenase domain containing protein 0.0044 0.065 0.0716
Loa Loa (eye worm) hypothetical protein 0.0044 0.065 0.1512
Mycobacterium ulcerans aldehyde dehydrogenase 0.0137 0.247 0.2381
Loa Loa (eye worm) hypothetical protein 0.0026 0.028 0.0653
Schistosoma mansoni retinal dehydrogenase 0.0017 0.0117 0.0117
Echinococcus multilocularis cytosolic malate dehydrogenase 0.0051 0.0784 0.0864
Echinococcus multilocularis Chromo domain 0.0026 0.028 0.0309
Loa Loa (eye worm) oxidoreductase 0.0017 0.0117 0.0273
Trypanosoma brucei mitochondrial malate dehydrogenase 0.0022 0.0199 0.0192
Brugia malayi hypothetical protein 0.0017 0.0117 0.0247
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0017 0.0117 0.0247
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0033 0.0428 0.0648
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.012 0.2129 0.4716
Loa Loa (eye worm) dehydrogenase 0.0017 0.0117 0.0273
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0026 0.028 0.0297
Treponema pallidum 1-deoxy-D-xylulose 5-phosphate reductoisomerase 0.052 1 1
Brugia malayi Steroid receptor seven-up type 2 0.0023 0.0223 0.0494
Schistosoma mansoni malate dehydrogenase 0.0022 0.0199 0.0207
Plasmodium falciparum chromodomain-helicase-DNA-binding protein 1 homolog, putative 0.0026 0.028 0.0165
Trichomonas vaginalis set domain proteins, putative 0.0262 0.492 1
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0138 0.2493 0.5569
Schistosoma mansoni short chain dehydrogenase 0.0017 0.0117 0.0117
Schistosoma mansoni 3-keto-dihydrosphingosine reductase 0.0017 0.0117 0.0117
Echinococcus granulosus cytosolic malate dehydrogenase 0.0051 0.0784 0.0864
Echinococcus granulosus Chromobox protein 3 0.0026 0.028 0.0309
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0017 0.0117 0.0247
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0017 0.0117 0.0247
Toxoplasma gondii lactate dehydrogenase LDH2 0.0022 0.0199 0.0083
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0017 0.0117 0.0247
Echinococcus multilocularis RUN 0.0044 0.065 0.0716
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.012 0.2129 0.8469
Loa Loa (eye worm) hypothetical protein 0.0023 0.0223 0.0519
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0017 0.0117 0.0247
Mycobacterium ulcerans 6-phosphofructokinase 0.012 0.2129 0.2036
Echinococcus multilocularis lactate dehydrogenase a 0.0022 0.0199 0.0219
Echinococcus granulosus Chromo domain 0.0026 0.028 0.0309
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0023 0.0223 0.0519
Loa Loa (eye worm) CXXC zinc finger family protein 0.0033 0.0427 0.0994
Loa Loa (eye worm) oxidoreductase 0.0017 0.0117 0.0273
Schistosoma mansoni short chain dehydrogenase 0.0017 0.0117 0.0117
Echinococcus multilocularis retinol dehydrogenase 11 0.0017 0.0117 0.0129
Schistosoma mansoni short chain dehydrogenase 0.0017 0.0117 0.0117
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0017 0.0117 0.0247
Loa Loa (eye worm) hypothetical protein 0.0017 0.0117 0.0273
Schistosoma mansoni 6-phosphofructokinase 0.012 0.2129 0.2337
Echinococcus granulosus malate dehydrogenase 0.0022 0.0199 0.0219
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0138 0.2493 0.2738
Brugia malayi serine/threonine-protein kinase plk-2 0.0213 0.3968 0.9232
Toxoplasma gondii 1-deoxy-D-xylulose 5-phosphate reductoisomerase, putative 0.052 1 1
Trichomonas vaginalis malate dehydrogenase, putative 0.004 0.0566 0.0935
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.028 0.034
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0026 0.028 0.034
Schistosoma mansoni cpg binding protein 0.0033 0.0427 0.0459
Trichomonas vaginalis chromobox protein, putative 0.0157 0.2868 0.5726
Trichomonas vaginalis CAMK family protein kinase 0.0213 0.3968 0.8018
Entamoeba histolytica hypothetical protein 0.0026 0.028 0.0424
Echinococcus multilocularis citrate lyase subunit beta protein 0.0027 0.0305 0.0336
Schistosoma mansoni loxhd1 0.0044 0.065 0.0704
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0026 0.028 0.0165
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.028 0.034
Trichomonas vaginalis CAMK family protein kinase 0.0106 0.185 0.3609
Echinococcus granulosus epidermal retinal dehydrogenase 2 0.0017 0.0117 0.0129
Loa Loa (eye worm) hypothetical protein 0.0023 0.0223 0.0519
Echinococcus multilocularis carbonyl reductase 1 0.0017 0.0117 0.0129
Trichomonas vaginalis Heterochromatin protein, putative 0.0026 0.028 0.034
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0059 0.0941 0.1026
Schistosoma mansoni steroid dehydrogenase 0.0017 0.0117 0.0117
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0023 0.0223 0.0494
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.012 0.2129 0.2036
Brugia malayi Hypothetical oxidoreductase F56D1.5 0.0017 0.0117 0.0247
Echinococcus granulosus muscleblind protein 0.0173 0.317 0.3494
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0027 0.0305 0.044
Plasmodium falciparum lactate dehydrogenase, putative 0.0022 0.0199 0.0083
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0023 0.0223 0.0494
Loa Loa (eye worm) oxidoreductase 0.0017 0.0117 0.0273
Echinococcus granulosus histone lysine methyltransferase setb 0.0034 0.0435 0.048
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0034 0.0435 0.048
Trichomonas vaginalis malate dehydrogenase, putative 0.0051 0.0784 0.1389
Echinococcus multilocularis chromobox protein 1 0.0157 0.2868 0.316
Brugia malayi hypothetical protein 0.0044 0.065 0.1489
Schistosoma mansoni tar DNA-binding protein 0.007 0.1147 0.1253
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0023 0.0223 0.0246
Onchocerca volvulus 0.0069 0.1134 0.2116
Loa Loa (eye worm) hypothetical protein 0.0017 0.0117 0.0273
Schistosoma mansoni steroid dehydrogenase 0.0017 0.0117 0.0117
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0053 0.0814 0.0886
Brugia malayi SET domain containing protein 0.0028 0.0319 0.0717
Toxoplasma gondii phosphofructokinase PFKII 0.0032 0.041 0.0297
Plasmodium falciparum LCCL domain-containing protein 0.0044 0.065 0.0539
Echinococcus granulosus carbonyl reductase 1 0.0017 0.0117 0.0129
Mycobacterium ulcerans hypothetical protein 0.0027 0.0305 0.019
Toxoplasma gondii histone lysine methyltransferase SET1 0.0064 0.1035 0.0929
Trichomonas vaginalis phosphofructokinase, putative 0.012 0.2129 0.4189
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0023 0.0223 0.0246
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0023 0.0223 0.0246
Loa Loa (eye worm) hypothetical protein 0.0017 0.0117 0.0273
Echinococcus multilocularis lipoxygenase domain containing protein 0.0044 0.065 0.0716
Schistosoma mansoni short chain dehydrogenase 0.0017 0.0117 0.0117
Echinococcus granulosus L lactate dehydrogenase B chain 0.0022 0.0199 0.0219
Trichomonas vaginalis phosphofructokinase, putative 0.012 0.2129 0.4189
Leishmania major cytosolic malate dehydrogenase 0.0051 0.0784 0.1563
Onchocerca volvulus 0.0023 0.0223 0.022
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0023 0.0223 0.0246
Trypanosoma cruzi polo-like protein kinase, putative 0.0213 0.3968 0.9028
Schistosoma mansoni short chain dehydrogenase 0.0017 0.0117 0.0117
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0017 0.0117 0.0247
Brugia malayi lactate dehydrogenase. 0.0022 0.0199 0.0438
Brugia malayi hypothetical protein 0.0044 0.065 0.1489
Schistosoma mansoni lipoxygenase 0.0044 0.065 0.0704
Brugia malayi M-phase phosphoprotein, mpp8 0.0026 0.028 0.0628
Brugia malayi hypothetical protein 0.0017 0.0117 0.0247
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.041 0.0611
Echinococcus multilocularis carbonyl reductase 1 0.0017 0.0117 0.0129
Echinococcus multilocularis 3 ketodihydrosphingosine reductase 0.0017 0.0117 0.0129
Echinococcus multilocularis malate dehydrogenase 0.0022 0.0199 0.0219
Echinococcus granulosus retinol dehydrogenase 11 0.0017 0.0117 0.0129
Trichomonas vaginalis malate dehydrogenase, putative 0.0051 0.0784 0.1389
Loa Loa (eye worm) oxidoreductase 0.0017 0.0117 0.0273
Entamoeba histolytica phosphofructokinase, putative 0.012 0.2129 0.5224
Brugia malayi Pre-SET motif family protein 0.0034 0.0435 0.0989
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0032 0.041 0.0297
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0023 0.0223 0.0234
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0032 0.041 0.0297
Plasmodium vivax lactate dehydrogenase 0.0022 0.0199 0.0083
Echinococcus granulosus RUN 0.0044 0.065 0.0716
Trypanosoma cruzi cytosolic malate dehydrogenase, putative 0.0051 0.0784 0.1563
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0017 0.0117 0.0247
Trichomonas vaginalis CAMK family protein kinase 0.0213 0.3968 0.8018
Schistosoma mansoni steroid hormone receptor ad4bp 0.0023 0.0223 0.0234
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0017 0.0117 0.0247
Toxoplasma gondii aldehyde dehydrogenase 0.0137 0.247 0.2381
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0053 0.0814 0.0897
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0032 0.041 0.0761
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0032 0.041 0.0297
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0032 0.041 0.0611
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.028 0.034
Echinococcus multilocularis Polycystic kidney disease protein 0.0044 0.065 0.0716
Loa Loa (eye worm) short chain dehydrogenase/reductase family oxidoreductase 0.0017 0.0117 0.0273
Echinococcus multilocularis lipoxygenase domain containing protein 0.0044 0.065 0.0716
Echinococcus granulosus cytosolic malate dehydrogenase 0.0051 0.0784 0.0864
Schistosoma mansoni kinase 0.0108 0.1906 0.209
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0027 0.0305 0.044
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.012 0.2129 0.1792
Echinococcus multilocularis cytosolic malate dehydrogenase 0.0051 0.0784 0.0864
Schistosoma mansoni tar DNA-binding protein 0.007 0.1147 0.1253
Plasmodium vivax hypothetical protein, conserved 0.0026 0.028 0.0165
Brugia malayi Type III restriction enzyme, res subunit family protein 0.0026 0.028 0.0628
Trichomonas vaginalis conserved hypothetical protein 0.0088 0.1508 0.2896
Loa Loa (eye worm) hypothetical protein 0.0017 0.0117 0.0273
Loa Loa (eye worm) 6-phosphofructokinase 0.012 0.2129 0.4954
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0213 0.3968 0.4373
Trichomonas vaginalis hypothetical protein 0.0026 0.028 0.034
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0137 0.247 0.9905
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0137 0.247 0.2722
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0023 0.0223 0.0494
Echinococcus multilocularis thyroid hormone receptor alpha 0.0023 0.0223 0.0246
Onchocerca volvulus 0.0262 0.492 1
Mycobacterium tuberculosis Probable citrate (pro-3S)-lyase (beta subunit) CitE (citrase) (citratase) (citritase) (citridesmolase) (citrase aldolase) 0.0027 0.0305 0.0791
Trypanosoma cruzi malate dehydrogenase, putative 0.0022 0.0199 0.0192
Trypanosoma cruzi cytosolic malate dehydrogenase, putative 0.0051 0.0784 0.1563
Loa Loa (eye worm) 6-phosphofructokinase 0.012 0.2129 0.4954
Trichomonas vaginalis malate dehydrogenase, putative 0.0051 0.0784 0.1389
Loa Loa (eye worm) hypothetical protein 0.0026 0.028 0.0653
Schistosoma mansoni tar DNA-binding protein 0.007 0.1147 0.1253
Loa Loa (eye worm) CHromoDomain protein family member 0.0028 0.0318 0.0739
Loa Loa (eye worm) hypothetical protein 0.0023 0.0223 0.0519
Schistosoma mansoni rab6-interacting 0.0044 0.065 0.0704
Schistosoma mansoni chromobox protein 0.0026 0.028 0.0297
Echinococcus multilocularis tar DNA binding protein 0.007 0.1147 0.1264
Leishmania major ATP-dependent phosphofructokinase 0.012 0.2129 0.4716
Echinococcus multilocularis muscleblind protein 0.0173 0.317 0.3494
Schistosoma mansoni chromobox protein 0.0157 0.2868 0.3152
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0053 0.0814 0.0897
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0138 0.2493 0.2404
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0012 0.0011 0.0012
Echinococcus multilocularis malate dehydrogenase 0.0022 0.0199 0.0219
Mycobacterium ulcerans malate dehydrogenase 0.0051 0.0784 0.0675
Loa Loa (eye worm) oxidoreductase 0.0017 0.0117 0.0273
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0023 0.0223 0.0494
Echinococcus granulosus 3 ketodihydrosphingosine reductase 0.0017 0.0117 0.0129
Mycobacterium leprae PROBABLE MALATE DEHYDROGENASE MDH 0.0051 0.0784 0.0675
Echinococcus granulosus Dehydrogenase:reductase SDR family 0.0017 0.0117 0.0129
Toxoplasma gondii lactate dehydrogenase LDH1 0.0022 0.0199 0.0083
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0023 0.0223 0.0246
Echinococcus granulosus oxidoreductase 0.0017 0.0117 0.0129
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0026 0.028 0.0165
Trichomonas vaginalis malate and lactate dehydrogenase, putative 0.0051 0.0784 0.1389
Brugia malayi oxidoreductase 0.0017 0.0117 0.0247
Echinococcus granulosus carbonyl reductase 1 0.0017 0.0117 0.0129
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0028 0.0318 0.035
Leishmania major glycosomal malate dehydrogenase 0.0022 0.0199 0.0192
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0121 0.215 0.5003
Plasmodium vivax 1-deoxy-D-xylulose 5-phosphate reductoisomerase, putative 0.052 1 1
Echinococcus granulosus lactate dehydrogenase a 0.0022 0.0199 0.0219
Brugia malayi steroid hormone receptor 0.0023 0.0223 0.0494
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0033 0.0428 0.0648
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0023 0.0223 0.0494
Leishmania major hypothetical protein, conserved 0.0234 0.4383 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0053 0.0814 0.0897
Schistosoma mansoni carbonyl reductase 0.0017 0.0117 0.0117
Loa Loa (eye worm) hypothetical protein 0.0017 0.0117 0.0273
Schistosoma mansoni short chain dehydrogenase 0.0017 0.0117 0.0117
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0095 0.164 0.317
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0026 0.028 0.034
Entamoeba histolytica serine/threonine protein kinase, putative 0.0213 0.3968 1
Echinococcus multilocularis lactate dehydrogenase a 0.0022 0.0199 0.0219
Schistosoma mansoni aldehyde dehydrogenase 0.0137 0.247 0.2713
Trypanosoma brucei cytosolic malate dehydrogenase 0.0051 0.0784 0.1563
Trypanosoma cruzi polo-like protein kinase, putative 0.0213 0.3968 0.9028
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0138 0.2493 0.2747
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0023 0.0223 0.0519
Schistosoma mansoni steroid dehydrogenase 0.0017 0.0117 0.0117
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0023 0.0223 0.0246
Entamoeba histolytica phosphofructokinase, putative 0.012 0.2129 0.5224
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.028 0.034
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.028 0.034
Schistosoma mansoni steroid dehydrogenase 0.0017 0.0117 0.0117
Echinococcus granulosus malate dehydrogenase 0.0022 0.0199 0.0219
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0023 0.0223 0.0246
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0023 0.0223 0.0234
Mycobacterium ulcerans 1-deoxy-D-xylulose 5-phosphate reductoisomerase 0.052 1 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0011 0.0026
Echinococcus multilocularis conserved hypothetical protein 0.0017 0.0117 0.0129
Brugia malayi CXXC zinc finger family protein 0.0033 0.0427 0.097
Mycobacterium leprae PROBABLE 1-DEOXY-D-XYLULOSE 5-PHOSPHATE REDUCTOISOMERASE DXR (DXP REDUCTOISOMERASE) (1-DEOXYXYLULOSE-5-PHOSPHATE REDUCTOISOMERAS 0.052 1 1
Schistosoma mansoni L-lactate dehydrogenase 0.0022 0.0199 0.0207
Brugia malayi TAR-binding protein 0.007 0.1147 0.2649
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0072 0.1183 0.1293
Schistosoma mansoni chromobox protein 0.0026 0.028 0.0297
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0023 0.0223 0.0246
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0138 0.2493 0.579
Wolbachia endosymbiont of Brugia malayi malate dehydrogenase 0.0022 0.0199 0.0083
Schistosoma mansoni steroid dehydrogenase 0.0017 0.0117 0.0117
Trichomonas vaginalis CAMK family protein kinase 0.0213 0.3968 0.8018
Leishmania major mitochondrial malate dehydrogenase 0.0022 0.0199 0.0192
Loa Loa (eye worm) malate dehydrogenase 0.0022 0.0199 0.0463
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0012 0.0011 0.0026
Schistosoma mansoni malate dehydrogenase 0.0022 0.0199 0.0207
Echinococcus multilocularis oxidoreductase 0.0017 0.0117 0.0129
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0213 0.3968 0.4373
Loa Loa (eye worm) hypothetical protein 0.0012 0.0011 0.0026
Trichomonas vaginalis Citrate lyase beta chain, putative 0.0027 0.0305 0.0391
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0023 0.0223 0.0246
Trichomonas vaginalis chromobox protein, putative 0.0157 0.2868 0.5726
Brugia malayi 6-phosphofructokinase 0.012 0.2129 0.4941
Brugia malayi Probable malate dehydrogenase, mitochondrial precursor 0.0022 0.0199 0.0438
Echinococcus multilocularis carbonyl reductase 1 0.0017 0.0117 0.0129
Plasmodium vivax SET domain protein, putative 0.0034 0.0435 0.0322
Trichomonas vaginalis malate dehydrogenase, putative 0.0051 0.0784 0.1389
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0023 0.0223 0.0519
Schistosoma mansoni steroid dehydrogenase 0.0017 0.0117 0.0117
Onchocerca volvulus 0.0044 0.065 0.1109
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0026 0.028 0.0165
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0033 0.0428 0.0648
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0053 0.0814 0.1873
Loa Loa (eye worm) oxidoreductase 0.0017 0.0117 0.0273
Schistosoma mansoni carbonyl reductase 0.0017 0.0117 0.0117
Echinococcus multilocularis cpg binding protein 0.0035 0.0464 0.0512
Echinococcus granulosus hypothetical protein 0.0017 0.0117 0.0129
Trypanosoma cruzi hypothetical protein, conserved 0.0234 0.4383 1
Schistosoma mansoni steroid dehydrogenase 0.0017 0.0117 0.0117
Schistosoma mansoni coup transcription factor 0.0023 0.0223 0.0234
Trichomonas vaginalis malate dehydrogenase, putative 0.0051 0.0784 0.1389
Echinococcus granulosus retinol dehydrogenase 11 0.0017 0.0117 0.0129
Trichomonas vaginalis CAMK family protein kinase 0.0213 0.3968 0.8018
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0137 0.247 0.2722
Onchocerca volvulus 0.0026 0.028 0.034
Echinococcus multilocularis chromobox protein 2 0.0026 0.028 0.0309
Brugia malayi Muscleblind-like protein 0.0173 0.317 0.7371
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0028 0.0318 0.035
Trypanosoma cruzi hypothetical protein, conserved 0.0234 0.4383 1
Plasmodium falciparum malate dehydrogenase 0.0022 0.0199 0.0083
Echinococcus granulosus carbonyl reductase 1 0.0017 0.0117 0.0129
Echinococcus multilocularis epidermal retinal dehydrogenase 2 0.0017 0.0117 0.0129
Mycobacterium ulcerans citrate lyase beta subunit, CitE_2 0.0027 0.0305 0.019
Trichomonas vaginalis chromobox protein, putative 0.0095 0.164 0.317
Brugia malayi Pre-SET motif family protein 0.023 0.4297 1
Loa Loa (eye worm) hypothetical protein 0.0023 0.0223 0.0519
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0023 0.0223 0.0494
Schistosoma mansoni hypothetical protein 0.0026 0.028 0.0297
Loa Loa (eye worm) hypothetical protein 0.0026 0.028 0.0653
Trichomonas vaginalis phosphofructokinase, putative 0.012 0.2129 0.4189
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0017 0.0117 0.0247
Brugia malayi RNA recognition motif domain containing protein 0.007 0.1147 0.2649
Wolbachia endosymbiont of Brugia malayi 1-deoxy-D-xylulose 5-phosphate reductoisomerase 0.052 1 1
Echinococcus multilocularis chromobox protein 1 0.0157 0.2868 0.316
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0023 0.0223 0.0494
Echinococcus multilocularis carbonyl reductase 1 0.0017 0.0117 0.0129
Leishmania major malate dehydrogenase, putative 0.0022 0.0199 0.0192
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0137 0.247 0.5516
Plasmodium vivax heterochromatin protein 1, putative 0.0026 0.028 0.0165
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0028 0.0318 0.0338
Trypanosoma brucei hypothetical protein, conserved 0.0234 0.4383 1
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0033 0.0428 0.0648
Trichomonas vaginalis malate dehydrogenase, putative 0.0051 0.0784 0.1389
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0023 0.0223 0.0519
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0033 0.0428 0.0648
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0026 0.028 0.034
Echinococcus granulosus WW domain containing oxidoreductase 0.0017 0.0117 0.0129
Echinococcus multilocularis lactate dehydrogenase protein 0.0022 0.0199 0.0219
Echinococcus multilocularis L lactate dehydrogenase B chain 0.0022 0.0199 0.0219
Plasmodium vivax hypothetical protein, conserved 0.0026 0.028 0.0165
Loa Loa (eye worm) hypothetical protein 0.0173 0.317 0.7378
Loa Loa (eye worm) oxidoreductase 0.0017 0.0117 0.0273
Onchocerca volvulus Serine\/threonine kinase homolog 0.0213 0.3968 0.8018
Schistosoma mansoni L-lactate dehydrogenase 0.0022 0.0199 0.0207
Schistosoma mansoni steroid dehydrogenase 0.0017 0.0117 0.0117
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0435 0.0468
Schistosoma mansoni short chain dehydrogenase 0.0017 0.0117 0.0117
Schistosoma mansoni tar DNA-binding protein 0.007 0.1147 0.1253
Loa Loa (eye worm) hypothetical protein 0.0088 0.1508 0.351
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.012 0.2129 0.4716
Echinococcus granulosus 6 phosphofructokinase 0.012 0.2129 0.2346
Brugia malayi nuclear hormone receptor 0.0023 0.0223 0.0494
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0138 0.2493 0.2747
Schistosoma mansoni short chain dehydrogenase 0.0017 0.0117 0.0117
Echinococcus granulosus FTZ F1 alpha 0.0023 0.0223 0.0246
Onchocerca volvulus Protein ultraspiracle homolog 0.0023 0.0223 0.022
Loa Loa (eye worm) hypothetical protein 0.0026 0.028 0.0653
Schistosoma mansoni short chain dehydrogenase 0.0017 0.0117 0.0117
Loa Loa (eye worm) hypothetical protein 0.0017 0.0117 0.0273
Onchocerca volvulus 0.0033 0.0427 0.0645
Onchocerca volvulus 0.0044 0.065 0.1109
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0017 0.0117 0.0247
Loa Loa (eye worm) oxidoreductase 0.0017 0.0117 0.0273
Schistosoma mansoni short chain dehydrogenase 0.0017 0.0117 0.0117
Loa Loa (eye worm) hypothetical protein 0.0017 0.0117 0.0273
Echinococcus granulosus hypothetical protein 0.0017 0.0117 0.0129
Onchocerca volvulus Bile acid receptor homolog 0.0023 0.0223 0.022
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0026 0.028 0.0424
Entamoeba histolytica hypothetical protein 0.0026 0.028 0.0424
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0023 0.0223 0.0494
Loa Loa (eye worm) steroid hormone receptor 0.0023 0.0223 0.0519
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0023 0.0223 0.0494
Echinococcus granulosus ecdysone induced protein 78C 0.0023 0.0223 0.0246
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.041 0.0611
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.028 0.034
Schistosoma mansoni hypothetical protein 0.0044 0.065 0.0704
Schistosoma mansoni oxidoreductase short chain dehydrogenase/reductase family 0.0017 0.0117 0.0117
Loa Loa (eye worm) hypothetical protein 0.0069 0.1134 0.2638
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0017 0.0117 0.0247
Loa Loa (eye worm) hypothetical protein 0.0017 0.0117 0.0273
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0034 0.0435 0.0322
Brugia malayi Protein cec-1. 0.0026 0.028 0.0628
Trichomonas vaginalis CAMK family protein kinase 0.0213 0.3968 0.8018
Schistosoma mansoni short chain dehydrogenase 0.0017 0.0117 0.0117
Loa Loa (eye worm) hypothetical protein 0.0034 0.0435 0.1013
Schistosoma mansoni hypothetical protein 0.0473 0.9073 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0117 0.0273
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.0027 0.0305 0.019
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0023 0.0223 0.0519
Echinococcus multilocularis muscleblind protein 1 0.0173 0.317 0.3494
Loa Loa (eye worm) dehydrogenase 0.0017 0.0117 0.0273
Loa Loa (eye worm) oxidoreductase 0.0017 0.0117 0.0273
Plasmodium falciparum 1-deoxy-D-xylulose 5-phosphate reductoisomerase 0.052 1 1
Echinococcus multilocularis FTZ F1 alpha 0.0023 0.0223 0.0246
Echinococcus granulosus lipoxygenase domain containing protein 0.0044 0.065 0.0716
Toxoplasma gondii malate dehydrogenase MDH 0.0022 0.0199 0.0083
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0125 0.2225 0.2453
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0017 0.0117 0.0247
Loa Loa (eye worm) hypothetical protein 0.0023 0.0223 0.0519
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0033 0.0428 0.0648
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0023 0.0223 0.022
Trichomonas vaginalis malate dehydrogenase, putative 0.0051 0.0784 0.1389
Plasmodium falciparum heterochromatin protein 1 0.0026 0.028 0.0165
Brugia malayi chromobox protein homolog 3 0.0088 0.1508 0.3493
Onchocerca volvulus 0.0026 0.028 0.034
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0029 0.0349 0.0483
Echinococcus multilocularis steroid dehydrogenase 0.0017 0.0117 0.0129
Trichomonas vaginalis CAMK family protein kinase 0.0213 0.3968 0.8018
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0125 0.2225 0.2453
Chlamydia trachomatis malate dehydrogenase 0.0051 0.0784 0.039
Echinococcus multilocularis Dehydrogenase:reductase SDR family 0.0017 0.0117 0.0129
Echinococcus granulosus dnaJ subfamily B 0.0473 0.9073 1
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.023 0.4297 1
Schistosoma mansoni 6-phosphofructokinase 0.012 0.2129 0.2337
Entamoeba histolytica phosphofructokinase, putative 0.012 0.2129 0.5224
Onchocerca volvulus 0.0059 0.0941 0.1716
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0023 0.0223 0.0494
Trichomonas vaginalis CAMK family protein kinase 0.0106 0.185 0.3609
Schistosoma mansoni hypothetical protein 0.0196 0.3627 0.399
Echinococcus granulosus chromodomain helicase DNA binding protein 1 0.0026 0.028 0.0309
Loa Loa (eye worm) hypothetical protein 0.0017 0.0117 0.0273
Loa Loa (eye worm) RNA binding protein 0.007 0.1147 0.2668
Loa Loa (eye worm) hypothetical protein 0.0026 0.028 0.0653
Schistosoma mansoni short chain dehydrogenase 0.0017 0.0117 0.0117
Brugia malayi Doublecortin family protein 0.0044 0.065 0.1489
Schistosoma mansoni hypothetical protein 0.0196 0.3627 0.399
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.041 0.0611
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0435 0.0468
Trichomonas vaginalis chromobox protein, putative 0.0026 0.028 0.034
Loa Loa (eye worm) malate dehydrogenase 0.0051 0.0784 0.1825
Schistosoma mansoni short chain dehydrogenase 0.0017 0.0117 0.0117
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0088 0.1508 0.2896
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0032 0.0397 0.0438
Schistosoma mansoni malate dehydrogenase 0.0051 0.0784 0.0853
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0017 0.0117 0.0247
Schistosoma mansoni nuclear hormone receptor 0.0023 0.0223 0.0234
Echinococcus multilocularis chromodomain helicase DNA binding protein 1 0.0026 0.028 0.0309
Entamoeba histolytica malate dehydrogenase, putative 0.0051 0.0784 0.1732
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.041 0.0611
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0435 0.0468
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0138 0.2493 0.2404
Echinococcus multilocularis geminin 0.0196 0.3627 0.3997
Mycobacterium ulcerans aldehyde dehydrogenase 0.0137 0.247 0.2381

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 0.4 uM Inhibition of Thermus flavus MDH pre-incubated for 4 mins before reaction initiation in presence of OAA and NAPH in absence of 0.01% Triton X100 by UV-Vis spectrophotometry ChEMBL. 24890653
IC50 (binding) = 4.1 uM Inhibition of His-tagged Escherichia coli DXR pre-incubated for 2 mins before reaction initiation in presence of 160 uM NADPH in absence of 0.01% Triton X100 ChEMBL. 24890653
Inhibition (binding) < 5 % Inhibition of His-tagged Escherichia coli DXR at 10 uM in presence of 160 uM NADPH ChEMBL. 24890653
Inhibition (binding) < 5 % Inhibition of Thermus flavus MDH at 50 uM pre-incubated for 4 mins before reaction initiation in presence of OAA and NAPH in presence of 0.01% Triton X100 by UV-Vis spectrophotometry ChEMBL. 24890653
Inhibition (binding) = 10 % Inhibition of His-tagged Escherichia coli DXR at 20 uM pre-incubated for 2 mins before reaction initiation in presence of 160 uM NADPH in presence of 0.01% Triton X100 ChEMBL. 24890653
Inhibition (binding) = 30 % Inhibition of His-tagged Escherichia coli DXR at 6 uM pre-incubated for 2 mins before reaction initiation in presence of 160 uM NADPH ChEMBL. 24890653
Inhibition (binding) = 38 % Inhibition of His-tagged Escherichia coli DXR at 6 uM pre-incubated for 2 mins before reaction initiation in absence of 160 uM NADPH ChEMBL. 24890653
Inhibition (binding) = 53 % Inhibition of His-tagged Escherichia coli DXR at 10 uM pre-incubated for 2 mins before reaction initiation in presence of 160 uM NADPH ChEMBL. 24890653

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.