Detailed information for compound 925520

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 403.151 | Formula: C10H7BrF4N4O2S
  • H donors: 1 H acceptors: 4 LogP: 1.37 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: BrCCc1nnn(c1)c1c(F)c(F)c(c(c1F)F)S(=O)(=O)N
  • InChi: 1S/C10H7BrF4N4O2S/c11-2-1-4-3-19(18-17-4)9-5(12)7(14)10(22(16,20)21)8(15)6(9)13/h3H,1-2H2,(H2,16,20,21)
  • InChiKey: JMWBFQICPMCBHK-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens carbonic anhydrase XII Starlite/ChEMBL References
Homo sapiens carbonic anhydrase IX Starlite/ChEMBL References
Homo sapiens carbonic anhydrase II Starlite/ChEMBL References
Homo sapiens carbonic anhydrase I Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis carbonic anhydrase II Get druggable targets OG5_127628 All targets in OG5_127628
Echinococcus granulosus carbonic anhydrase II Get druggable targets OG5_127628 All targets in OG5_127628
Leishmania major carbonic anhydrase-like protein Get druggable targets OG5_127628 All targets in OG5_127628
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) Get druggable targets OG5_127628 All targets in OG5_127628
Leishmania mexicana carbonic anhydrase-like protein Get druggable targets OG5_127628 All targets in OG5_127628
Leishmania braziliensis carbonic anhydrase-like protein Get druggable targets OG5_127628 All targets in OG5_127628
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) Get druggable targets OG5_127628 All targets in OG5_127628
Trypanosoma cruzi carbonic anhydrase-like protein, putative Get druggable targets OG5_127628 All targets in OG5_127628
Leishmania donovani carbonic anhydrase-like protein Get druggable targets OG5_127628 All targets in OG5_127628
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase Get druggable targets OG5_127628 All targets in OG5_127628
Loa Loa (eye worm) carbonic anhydrase 3 Get druggable targets OG5_127628 All targets in OG5_127628
Trypanosoma brucei carbonic anhydrase-like protein Get druggable targets OG5_127628 All targets in OG5_127628
Trypanosoma congolense carbonic anhydrase-like protein Get druggable targets OG5_127628 All targets in OG5_127628
Trypanosoma congolense carbonic anhydrase-like protein Get druggable targets OG5_127628 All targets in OG5_127628
Trypanosoma brucei gambiense carbonic anhydrase-like protein Get druggable targets OG5_127628 All targets in OG5_127628
Brugia malayi Eukaryotic-type carbonic anhydrase family protein Get druggable targets OG5_127628 All targets in OG5_127628
Schistosoma japonicum ko:K01672 carbonic anhydrase [EC4.2.1.1], putative Get druggable targets OG5_127628 All targets in OG5_127628
Leishmania infantum carbonic anhydrase-like protein Get druggable targets OG5_127628 All targets in OG5_127628
Trypanosoma cruzi carbonic anhydrase-like protein, putative Get druggable targets OG5_127628 All targets in OG5_127628
Brugia malayi Putative carbonic anhydrase 5 precursor Get druggable targets OG5_127628 All targets in OG5_127628
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma cruzi carbonic anhydrase-like protein, putative carbonic anhydrase XII 354 aa 295 aa 23.1 %
Brugia malayi Carbonic anhydrase like protein 2 precursor carbonic anhydrase II 260 aa 259 aa 32.0 %
Trypanosoma brucei carbonic anhydrase-like protein carbonic anhydrase I 261 aa 281 aa 25.3 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis geminin 0.0875 0.97 0.97
Echinococcus multilocularis BC026374 protein (S09 family) 0.0152 0.1539 0.1538
Echinococcus granulosus chromobox protein 1 0.0078 0.0695 0.0695
Echinococcus multilocularis dnaJ subfamily B 0.0456 0.4965 0.4965
Mycobacterium tuberculosis Probable dehydrogenase 0.0084 0.0762 0.2718
Echinococcus granulosus lamin dm0 0.003 0.0158 0.0157
Brugia malayi Augmenter of liver regeneration 0.0036 0.0219 0.0219
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0151 0.1528 0.1528
Echinococcus granulosus glutamate receptor ionotropic kainate 0.0048 0.0361 0.0361
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.004 0.0271 0.1579
Loa Loa (eye worm) histone methyltransferase 0.0019 0.0027 0.0027
Loa Loa (eye worm) acetylcholinesterase 1 0.0902 1 1
Echinococcus multilocularis snurportin 1 0.0298 0.3184 0.3184
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0043 0.0307 0.6649
Echinococcus granulosus glutamate receptor 2 0.0107 0.1021 0.102
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0152 0.1539 0.1538
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0479 0.5222 0.5222
Mycobacterium tuberculosis Probable esterase LipL 0.004 0.0271 0.0887
Plasmodium falciparum importin beta, putative 0.0028 0.0134 0.0768
Echinococcus granulosus Alpha N acetylgalactosaminidase 0.0107 0.1032 0.1031
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0026 0.0115 0.0477
Loa Loa (eye worm) hypothetical protein 0.0187 0.1932 0.1932
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0152 0.1539 0.1538
Mycobacterium ulcerans esterase/lipase LipP 0.004 0.0271 0.1579
Mycobacterium ulcerans hypothetical protein 0.004 0.0271 0.1579
Loa Loa (eye worm) hypothetical protein 0.0025 0.0097 0.0097
Echinococcus multilocularis lamin 0.003 0.0158 0.0157
Loa Loa (eye worm) hypothetical protein 0.0152 0.1539 0.1539
Echinococcus granulosus glutamate receptor ionotropic kainate 3 0.0048 0.0361 0.0361
Loa Loa (eye worm) hypothetical protein 0.0134 0.1333 0.1333
Schistosoma mansoni intermediate filament proteins 0.003 0.0158 0.0157
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.005 0.005
Loa Loa (eye worm) hypothetical protein 0.0134 0.1333 0.1333
Brugia malayi chromobox protein homolog 3 0.0044 0.031 0.031
Schistosoma mansoni hypothetical protein 0.0298 0.3184 0.3184
Loa Loa (eye worm) hypothetical protein 0.004 0.0271 0.0271
Loa Loa (eye worm) metabotropic glutamate receptor 8 0.0025 0.0097 0.0097
Echinococcus multilocularis metabotropic glutamate receptor 2 0.0025 0.0097 0.0096
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0093 0.0867 0.3111
Schistosoma mansoni glutamate receptor NMDA 0.041 0.4446 0.4445
Brugia malayi Carboxylesterase family protein 0.0152 0.1539 0.1539
Echinococcus granulosus glutamate NMDA receptor subunit 0.0309 0.3303 0.3303
Leishmania major alpha glucosidase II subunit, putative 0.0038 0.0246 0.0824
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0037 0.0232 0.074
Plasmodium vivax ataxin-2 like protein, putative 0.0055 0.0444 1
Mycobacterium tuberculosis Probable oxidoreductase 0.0093 0.0867 0.3111
Schistosoma mansoni hypothetical protein 0.0151 0.1528 0.1528
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0134 0.1333 0.1333
Loa Loa (eye worm) glutathione reductase 0.0037 0.0232 0.0232
Mycobacterium tuberculosis Carboxylesterase LipT 0.0152 0.1539 0.5618
Trichomonas vaginalis chromobox protein, putative 0.0078 0.0695 0.3845
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.01 0.0943 0.0943
Brugia malayi Putative carbonic anhydrase 5 precursor 0.0248 0.2616 0.2616
Schistosoma mansoni survival motor neuron protein 0.005 0.0382 0.0382
Brugia malayi beta-lactamase family protein 0.004 0.0271 0.0271
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0038 0.0246 0.1242
Schistosoma mansoni tyrosine kinase 0.0025 0.0097 0.0096
Entamoeba histolytica hypothetical protein 0.0039 0.0258 0.9005
Echinococcus multilocularis tyrosine kinase 0.0025 0.0097 0.0096
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0026 0.0115 0.0477
Loa Loa (eye worm) hypothetical protein 0.0152 0.1539 0.1539
Loa Loa (eye worm) intermediate filament protein 0.003 0.0158 0.0158
Echinococcus multilocularis glutamate (NMDA) receptor subunit 0.0309 0.3303 0.3303
Brugia malayi Glycosyl hydrolases family 31 protein 0.0171 0.1748 0.1748
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0271 0.1386
Echinococcus multilocularis survival motor neuron protein 1 0.0245 0.2581 0.2581
Plasmodium vivax importin-beta 2, putative 0.0028 0.0134 0.2433
Trypanosoma brucei trypanothione reductase 0.0037 0.0232 0.0767
Mycobacterium ulcerans lipase LipD 0.004 0.0271 0.1579
Schistosoma mansoni ran 0.0021 0.005 0.005
Onchocerca volvulus 0.005 0.0382 0.1554
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.005 0.005
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0246 0.0824
Echinococcus granulosus acetylcholinesterase 0.0902 1 1
Echinococcus multilocularis transcription factor btf3 0.0039 0.0258 0.0258
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.005 0.0715
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.004 0.0271 0.0271
Toxoplasma gondii thioredoxin reductase 0.0037 0.0232 0.1525
Echinococcus granulosus BC026374 protein S09 family 0.0152 0.1539 0.1538
Plasmodium vivax FAD-linked sulfhydryl oxidase ERV1, putative 0.0036 0.0219 0.4517
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0171 0.1748 0.1748
Toxoplasma gondii Erv1 / Alr family protein 0.0036 0.0219 0.1426
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.01 0.0943 0.0943
Loa Loa (eye worm) hypothetical protein 0.004 0.0271 0.0271
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0038 0.0246 0.1242
Loa Loa (eye worm) hypothetical protein 0.0152 0.1539 0.1539
Echinococcus granulosus beta LACTamase domain containing family member 0.004 0.0271 0.0271
Echinococcus granulosus glutamate receptor NMDA 0.0255 0.27 0.27
Echinococcus multilocularis GPCR, family 2 0.0151 0.1528 0.1528
Trichomonas vaginalis esterase, putative 0.004 0.0271 0.1386
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0041 0.0283 1
Schistosoma mansoni metabotropic glutamate receptor 0.0025 0.0097 0.0096
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.01 0.0943 0.0943
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.005 0.0064
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.01 0.0943 0.0943
Loa Loa (eye worm) hypothetical protein 0.0025 0.0097 0.0097
Brugia malayi Inositol-1 0.0041 0.0283 0.0283
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0152 0.1539 0.5618
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0107 0.1032 0.1031
Loa Loa (eye worm) hypothetical protein 0.0025 0.0097 0.0097
Plasmodium falciparum FAD-linked sulfhydryl oxidase ERV1, putative 0.0036 0.0219 0.1426
Brugia malayi Receptor family ligand binding region containing protein 0.0025 0.0097 0.0097
Loa Loa (eye worm) hypothetical protein 0.003 0.0158 0.0158
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0246 0.1242
Schistosoma mansoni ATP-binding cassette transporter 0.013 0.1285 0.1285
Entamoeba histolytica hypothetical protein 0.004 0.0271 0.9516
Echinococcus granulosus geminin 0.0875 0.97 0.97
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0152 0.1539 0.5618
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.0155 0.1563 0.1563
Echinococcus granulosus thioredoxin glutathione reductase 0.0037 0.0237 0.0237
Plasmodium vivax basic transcription factor 3b, putative 0.0039 0.0258 0.547
Echinococcus granulosus dnaJ subfamily B 0.0456 0.4965 0.4965
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0248 0.2616 1
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0258 0.131
Plasmodium vivax glutathione reductase, putative 0.0037 0.0232 0.483
Onchocerca volvulus 0.004 0.0271 0.0952
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0246 0.1242
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0134 0.1333 0.1333
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.0048 0.0361 0.0361
Leishmania major basic transcription factor 3a, putative 0.0039 0.0258 0.0869
Schistosoma mansoni lamin 0.003 0.0158 0.0157
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0246 0.1242
Schistosoma mansoni carbonic anhydrase 0.0134 0.1333 0.1333
Schistosoma mansoni BC026374 protein (S09 family) 0.0152 0.1539 0.1538
Trypanosoma cruzi trypanothione reductase, putative 0.0037 0.0232 0.0767
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0084 0.0762 0.2718
Loa Loa (eye worm) hypothetical protein 0.0025 0.0097 0.0097
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0127 0.1251 0.1251
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0155 0.1563 0.1563
Echinococcus multilocularis glutamate receptor 2 0.0155 0.1563 0.1563
Brugia malayi Glycosyl hydrolases family 31 protein 0.0038 0.0246 0.0246
Echinococcus multilocularis importin subunit beta 1 0.0028 0.0134 0.0133
Brugia malayi metabotropic glutamate receptor type 2 0.0025 0.0097 0.0097
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0151 0.1528 0.1528
Echinococcus granulosus histone acetyltransferase KAT2B 0.0143 0.1432 0.1432
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0041 0.0283 1
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 0.0036 0.0219 0.0718
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0041 0.0283 0.1918
Trypanosoma cruzi extracellular receptor, putative 0.0025 0.0097 0.0243
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0038 0.0246 0.8537
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0134 0.1333 0.1333
Leishmania major hypothetical protein, conserved 0.0036 0.0219 0.0718
Loa Loa (eye worm) receptor family ligand binding region containing protein 0.0025 0.0097 0.0097
Echinococcus granulosus carbonic anhydrase 0.0134 0.1333 0.1333
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.01 0.0943 0.0943
Echinococcus granulosus glutamate receptor 2 0.0155 0.1563 0.1563
Echinococcus granulosus carbonic anhydrase II 0.0248 0.2616 0.2616
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0166 0.0775
Leishmania major GTP-binding protein, putative 0.0021 0.005 0.0064
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0034 0.5
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0038 0.0246 0.1637
Loa Loa (eye worm) hypothetical protein 0.004 0.0271 0.0271
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0093 0.0867 1
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0026 0.0115 0.0477
Schistosoma mansoni hypothetical protein 0.0327 0.3512 0.3512
Toxoplasma gondii histone lysine methyltransferase SET1 0.0117 0.1138 0.8501
Mycobacterium tuberculosis Probable lipase LipD 0.004 0.0271 0.0887
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.005 0.005
Schistosoma mansoni hypothetical protein 0.005 0.0382 0.0382
Schistosoma mansoni gliotactin 0.0152 0.1539 0.1538
Loa Loa (eye worm) ICD-1 protein 0.0039 0.0258 0.0258
Brugia malayi hypothetical protein 0.0055 0.0444 0.0444
Onchocerca volvulus 0.006 0.0494 0.2164
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0155 0.1563 0.1563
Echinococcus granulosus FAD linked sulfhydryl oxidase ALR 0.0036 0.0219 0.0219
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0041 0.0283 0.0965
Onchocerca volvulus 0.0152 0.1539 0.7859
Trichomonas vaginalis chromobox protein, putative 0.0078 0.0695 0.3845
Plasmodium falciparum basic transcription factor 3b, putative 0.0039 0.0258 0.1727
Mycobacterium tuberculosis Probable reductase 0.0084 0.0762 0.2718
Echinococcus granulosus histone acetyltransferase KAT2B 0.0043 0.0307 0.0306
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0155 0.1563 0.1563
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0034 0.0034
Echinococcus multilocularis nmda type glutamate receptor 0.028 0.2979 0.2979
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0248 0.2616 0.2616
Onchocerca volvulus 0.0099 0.0934 0.4566
Loa Loa (eye worm) carboxylesterase 0.0152 0.1539 0.1539
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0026 0.0115 0.0477
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0258 0.131
Brugia malayi beta-lactamase 0.004 0.0271 0.0271
Schistosoma mansoni metabotropic glutamate receptor 0.0025 0.0097 0.0096
Loa Loa (eye worm) glutamate receptor 1 0.013 0.1285 0.1285
Echinococcus multilocularis metabotropic glutamate receptor 5 0.0025 0.0097 0.0096
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0248 0.2616 1
Echinococcus multilocularis lysosomal alpha glucosidase 0.0171 0.1748 0.1748
Loa Loa (eye worm) RGC/RGC protein kinase 0.0025 0.0097 0.0097
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.01 0.0943 0.0943
Brugia malayi glutathione reductase 0.0037 0.0232 0.0232
Brugia malayi hypothetical protein 0.0152 0.1539 0.1539
Echinococcus granulosus nmda type glutamate receptor 0.028 0.2979 0.2979
Echinococcus multilocularis Glycoside hydrolase, family 27 0.0107 0.1032 0.1031
Brugia malayi Receptor family ligand binding region containing protein 0.0025 0.0097 0.0097
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.005 0.0405
Echinococcus granulosus inositol monophosphatase 1 0.0041 0.0283 0.0283
Schistosoma mansoni cpg binding protein 0.0063 0.0532 0.0532
Brugia malayi Cytochrome P450 family protein 0.005 0.0387 0.0387
Entamoeba histolytica Ran family GTPase 0.0021 0.005 0.0666
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0479 0.5222 0.5222
Loa Loa (eye worm) hypothetical protein 0.0245 0.2581 0.2581
Echinococcus multilocularis carbonic anhydrase 0.0134 0.1333 0.1333
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.005 0.0128
Loa Loa (eye worm) glutamate receptor 2 0.013 0.1285 0.1285
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.005 0.005
Mycobacterium tuberculosis Conserved protein 0.004 0.0271 0.0887
Loa Loa (eye worm) latrophilin receptor protein 2 0.0151 0.1528 0.1528
Echinococcus granulosus neuroligin 0.0152 0.1539 0.1538
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0041 0.0283 0.1656
Brugia malayi hypothetical protein 0.0245 0.2581 0.2581
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0034 0.0033
Echinococcus granulosus carboxylesterase 5A 0.0902 1 1
Echinococcus multilocularis atrial natriuretic peptide receptor 0.0025 0.0097 0.0096
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.005 0.0064
Echinococcus multilocularis neutral alpha glucosidase AB 0.0038 0.0246 0.0246
Leishmania major hypothetical protein, conserved 0.0055 0.0444 0.1589
Schistosoma mansoni alpha-glucosidase 0.0147 0.1479 0.1479
Echinococcus multilocularis beta LACTamase domain containing family member 0.004 0.0271 0.0271
Echinococcus granulosus microtubule associated protein 2 0.0724 0.7993 0.7993
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0084 0.0762 0.2718
Echinococcus multilocularis cpg binding protein 0.0063 0.0532 0.0532
Brugia malayi hypothetical protein 0.0036 0.0222 0.0222
Echinococcus multilocularis Alpha N acetylgalactosaminidase 0.0107 0.1032 0.1031
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.0155 0.1563 0.1563
Onchocerca volvulus 0.0161 0.1633 0.8372
Loa Loa (eye worm) hypothetical protein 0.0134 0.1333 0.1333
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0034 0.0006
Echinococcus granulosus chromobox protein 1 0.0078 0.0695 0.0695
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0152 0.1539 0.1538
Mycobacterium leprae Probable lipase LipE 0.004 0.0271 0.0584
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0271 0.092
Trypanosoma brucei carbonic anhydrase-like protein 0.0248 0.2616 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0026 0.0115 0.0477
Mycobacterium ulcerans carboxylesterase, LipT 0.0152 0.1539 1
Brugia malayi Importin beta-1 subunit 0.0028 0.0134 0.0134
Schistosoma mansoni lamin 0.003 0.0158 0.0157
Schistosoma mansoni ran 0.0021 0.005 0.005
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0248 0.2616 0.2616
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0152 0.1539 0.8745
Loa Loa (eye worm) hypothetical protein 0.0902 1 1
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0155 0.1563 0.1563
Brugia malayi RNA, U transporter 1 0.0079 0.0715 0.0715
Echinococcus multilocularis lysosomal alpha glucosidase 0.0171 0.1748 0.1748
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0072 0.0627 0.0627
Toxoplasma gondii ABC1 family protein 0.004 0.0271 0.1828
Trichomonas vaginalis penicillin-binding protein, putative 0.004 0.0271 0.1386
Trypanosoma brucei PAB1-binding protein , putative 0.0055 0.0444 0.1589
Loa Loa (eye worm) hypothetical protein 0.0028 0.0134 0.0134
Schistosoma mansoni alpha glucosidase 0.0038 0.0246 0.0246
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0151 0.1528 0.1528
Loa Loa (eye worm) hypothetical protein 0.0025 0.0097 0.0097
Brugia malayi hypothetical protein 0.0161 0.1633 0.1633
Entamoeba histolytica hypothetical protein 0.0023 0.0074 0.1613
Echinococcus multilocularis carbonic anhydrase 0.0134 0.1333 0.1333
Leishmania major importin beta-1 subunit, putative 0.0023 0.0074 0.0156
Schistosoma mansoni hypothetical protein 0.0875 0.97 0.97
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0246 0.0824
Echinococcus granulosus GPCR family 2 0.0151 0.1528 0.1528
Brugia malayi N-terminal motif family protein 0.0187 0.1932 0.1932
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0084 0.0762 0.8336
Echinococcus multilocularis nmda type glutamate receptor 0.0303 0.3243 0.3243
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0041 0.0283 0.1454
Echinococcus granulosus intermediate filament protein 0.003 0.0158 0.0157
Brugia malayi Carboxylesterase family protein 0.0902 1 1
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.005 0.0064
Leishmania major trypanothione reductase 0.0037 0.0232 0.0767
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0155 0.1563 0.1563
Echinococcus granulosus survival motor neuron protein 1 0.0245 0.2581 0.2581
Trichomonas vaginalis chromobox protein, putative 0.0047 0.0347 0.1825
Schistosoma mansoni glutamate receptor kainate 0.013 0.1285 0.1285
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0152 0.1539 0.1538
Onchocerca volvulus 0.003 0.0158 0.0333
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0248 0.2616 0.2616
Schistosoma mansoni hypothetical protein 0.0025 0.0099 0.0099
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0084 0.0762 0.2718
Echinococcus granulosus para nitrobenzyl esterase 0.0152 0.1539 0.1538
Toxoplasma gondii HEAT repeat-containing protein 0.0028 0.0134 0.0768
Mycobacterium tuberculosis Probable conserved lipoprotein 0.004 0.0271 0.0887
Trichomonas vaginalis alpha-galactosidase/alpha-N-acetylgalactosaminidase, putative 0.0072 0.0627 0.3453
Echinococcus multilocularis inositol monophosphatase 1 0.0041 0.0283 0.0283
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.01 0.0943 0.0943
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0147 0.1479 0.1478
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0034 0.0033
Brugia malayi intermediate filament protein 0.003 0.0158 0.0158
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0902 1 1
Toxoplasma gondii Erv1 / Alr family protein 0.0036 0.0219 0.1426
Loa Loa (eye worm) hypothetical protein 0.0152 0.1539 0.1539
Loa Loa (eye worm) carbonic anhydrase 3 0.0248 0.2616 0.2616
Schistosoma mansoni hypothetical protein 0.0456 0.4965 0.4965
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0271 0.1386
Loa Loa (eye worm) hypothetical protein 0.0152 0.1539 0.1539
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0038 0.0246 0.8537
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0043 0.0307 0.159
Brugia malayi Carboxylesterase family protein 0.0152 0.1539 0.1539
Plasmodium falciparum histone acetyltransferase GCN5 0.004 0.0266 0.1786
Brugia malayi hypothetical protein 0.0025 0.0097 0.0097
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0034 0.0034
Leishmania major carbonic anhydrase-like protein 0.0248 0.2616 1
Schistosoma mansoni protein kinase 0.0025 0.0097 0.0096
Echinococcus multilocularis glutamate receptor 2 0.0107 0.1021 0.102
Echinococcus granulosus receptor type guanylyl cyclase 0.0025 0.0097 0.0096
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0134 0.1333 0.1333
Onchocerca volvulus 0.0152 0.1539 0.7859
Loa Loa (eye worm) glutamate receptor 0.0025 0.0097 0.0097
Brugia malayi Carboxylesterase family protein 0.0152 0.1539 0.1539
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0271 0.1386
Schistosoma mansoni tyrosine kinase 0.0025 0.0097 0.0096
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0134 0.0387
Mycobacterium tuberculosis Probable lipase LipE 0.004 0.0271 0.0887
Echinococcus granulosus carbonic anhydrase 0.0134 0.1333 0.1333
Echinococcus granulosus transcription factor btf3 0.0039 0.0258 0.0258
Loa Loa (eye worm) hypothetical protein 0.004 0.0271 0.0271
Loa Loa (eye worm) hypothetical protein 0.0025 0.0097 0.0097
Echinococcus granulosus metabotropic glutamate receptor 2 0.0025 0.0097 0.0096
Mycobacterium tuberculosis Conserved protein 0.004 0.0271 0.0887
Plasmodium falciparum ataxin-2 like protein, putative 0.0055 0.0444 0.3157
Entamoeba histolytica hypothetical protein 0.004 0.0271 0.9516
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0041 0.0283 0.1454
Plasmodium falciparum glutathione reductase 0.0037 0.0232 0.1525
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0134 0.0387
Loa Loa (eye worm) hypothetical protein 0.0152 0.1539 0.1539
Brugia malayi beta-NAC-like protein 0.0039 0.0258 0.0258
Echinococcus granulosus metabotropic glutamate receptor 5 0.0025 0.0097 0.0096
Loa Loa (eye worm) hypothetical protein 0.0025 0.0097 0.0097
Onchocerca volvulus 0.0034 0.0203 0.0583
Echinococcus multilocularis lamin dm0 0.003 0.0158 0.0157
Mycobacterium tuberculosis Probable hydrolase 0.004 0.0271 0.0887
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.004 0.0271 0.0271
Loa Loa (eye worm) beta-lactamase 0.004 0.0271 0.0271
Echinococcus multilocularis microtubule associated protein 2 0.0724 0.7993 0.7993
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0019 0.0027 0.0027
Echinococcus granulosus carbonic anhydrase 0.0134 0.1333 0.1333
Toxoplasma gondii melibiase subfamily protein 0.0107 0.1032 0.7678
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.01 0.0943 0.0943
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0271 0.092
Echinococcus multilocularis glutamate receptor ionotropic kainate 0.0048 0.0361 0.0361
Schistosoma mansoni ap endonuclease 0.0019 0.0034 0.0033
Loa Loa (eye worm) hypothetical protein 0.0025 0.0097 0.0097
Schistosoma mansoni glutamate receptor AMPA 0.013 0.1285 0.1285
Schistosoma mansoni cpg binding protein 0.0063 0.0532 0.0532
Giardia lamblia Histone acetyltransferase GCN5 0.004 0.0266 1
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0074 0.024
Loa Loa (eye worm) metabotropic GABA-B receptor subtype 2 0.0025 0.0097 0.0097
Echinococcus granulosus lamin 0.003 0.0158 0.0157
Echinococcus granulosus nmda type glutamate receptor 0.0303 0.3243 0.3243
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0044 0.0065
Mycobacterium tuberculosis Conserved protein 0.004 0.0271 0.0887
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 0.0036 0.0219 0.0718
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0166 0.0775
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0134 0.1333 0.1333
Entamoeba histolytica hypothetical protein 0.004 0.0271 0.9516
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.004 0.0271 0.0271
Onchocerca volvulus 0.0152 0.1539 0.7859
Echinococcus granulosus Ribosomal protein S1 RNA binding domain 0.0048 0.0361 0.0361
Echinococcus multilocularis carbonic anhydrase II 0.0248 0.2616 0.2616
Trichomonas vaginalis bromodomain-containing protein, putative 0.0043 0.0307 0.159
Loa Loa (eye worm) thioredoxin reductase 0.0037 0.0232 0.0232
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0041 0.0283 0.0965
Loa Loa (eye worm) RGC/RGC protein kinase 0.0025 0.0097 0.0097
Echinococcus multilocularis Ribosomal protein S1, RNA binding domain 0.0048 0.0361 0.0361
Loa Loa (eye worm) hypothetical protein 0.0044 0.031 0.031
Loa Loa (eye worm) hypothetical protein 0.004 0.0271 0.0271
Trypanosoma cruzi ERV/ALR sulfhydryl oxidase domain-containing protein 0.0036 0.0219 0.0718
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0093 0.0867 0.3111
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0258 0.131
Schistosoma mansoni importin beta-1 0.0028 0.0134 0.0133
Loa Loa (eye worm) cytochrome P450 family protein 0.005 0.0387 0.0387
Schistosoma mansoni glutamate receptor kainate 0.013 0.1285 0.1285
Schistosoma mansoni carbonic anhydrase-related 0.0134 0.1333 0.1333
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.004 0.0271 0.0271
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0134 0.1333 0.1333
Schistosoma mansoni ap endonuclease 0.0019 0.0034 0.0033
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0025 0.0099 0.0099
Trichomonas vaginalis sucrase-isomaltase, putative 0.0038 0.0246 0.1242
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0037 0.0234 0.0749
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.005 0.0128
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0107 0.1032 0.1031
Onchocerca volvulus 0.003 0.0158 0.0333
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.01 0.0943 0.0943
Trichomonas vaginalis chromobox protein, putative 0.0047 0.0347 0.1825
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0026 0.0115 0.0477
Mycobacterium ulcerans beta-lactamase 0.004 0.0271 0.1579
Loa Loa (eye worm) RGC/RGC protein kinase 0.0025 0.0097 0.0097
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0151 0.1528 0.1528
Loa Loa (eye worm) hypothetical protein 0.0151 0.1528 0.1528
Loa Loa (eye worm) hypothetical protein 0.0072 0.0627 0.0627
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0026 0.0115 0.0477
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.003 0.0158 0.0158
Loa Loa (eye worm) carboxylesterase 0.0902 1 1
Schistosoma mansoni acetylcholinesterase 0.0152 0.1539 0.1538
Trypanosoma cruzi PAB1-binding protein , putative 0.0055 0.0444 0.1589
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0044 0.031 0.1161
Schistosoma mansoni hypothetical protein 0.0151 0.1528 0.1528
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0256 0.2712 1
Onchocerca volvulus 0.0152 0.1539 0.7859
Schistosoma mansoni hypothetical protein 0.004 0.0271 0.0271
Onchocerca volvulus 0.004 0.0271 0.0952
Brugia malayi Calcitonin receptor-like protein seb-1 0.0479 0.5222 0.5222
Loa Loa (eye worm) heterochromatin protein 1 0.0078 0.0695 0.0695
Trypanosoma brucei glucosidase, putative 0.0038 0.0246 0.0824
Loa Loa (eye worm) acetyltransferase 0.0147 0.1479 0.1479
Echinococcus granulosus neutral alpha glucosidase AB 0.0038 0.0246 0.0246
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.002 0.0044 0.0065
Loa Loa (eye worm) hepatopoietin HPO2 0.0036 0.0219 0.0219
Schistosoma mansoni transcription factor btf3 0.0039 0.0258 0.0258
Trypanosoma cruzi transcription factor btf3, putative 0.0039 0.0258 0.0869
Plasmodium vivax hypothetical protein, conserved 0.004 0.0271 0.5789
Trichomonas vaginalis conserved hypothetical protein 0.0172 0.1755 1
Toxoplasma gondii LsmAD domain-containing protein 0.0055 0.0444 0.3157
Echinococcus multilocularis glutamate receptor 2 0.013 0.1285 0.1285
Loa Loa (eye worm) hypothetical protein 0.0034 0.0203 0.0203
Schistosoma mansoni chromobox protein 0.0078 0.0695 0.0695
Echinococcus granulosus acetylcholinesterase 0.0902 1 1
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0074 0.024
Loa Loa (eye worm) hypothetical protein 0.0902 1 1
Brugia malayi hypothetical protein 0.004 0.0271 0.0271
Schistosoma mansoni inositol monophosphatase 0.0041 0.0283 0.0283
Mycobacterium leprae conserved hypothetical protein 0.004 0.0271 0.0584
Brugia malayi acetyltransferase, GNAT family protein 0.0147 0.1479 0.1479
Schistosoma mansoni hypothetical protein 0.0048 0.0361 0.0361
Brugia malayi Thioredoxin reductase 0.0037 0.0232 0.0232
Entamoeba histolytica hypothetical protein 0.0025 0.0097 0.2521
Trypanosoma cruzi PAB1-binding protein , putative 0.0055 0.0444 0.1589
Schistosoma mansoni hypothetical protein 0.0134 0.1333 0.1333
Schistosoma mansoni hypothetical protein 0.0151 0.1528 0.1528
Brugia malayi metabotropic GABA-B receptor subtype 2 0.0025 0.0097 0.0097
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0147 0.1479 0.1478
Schistosoma mansoni microtubule-associated protein tau 0.0724 0.7993 0.7993
Brugia malayi Heterochromatin protein 1 0.0078 0.0695 0.0695
Brugia malayi latrophilin 2 splice variant baaae 0.0327 0.3512 0.3512
Echinococcus multilocularis receptor type guanylyl cyclase 0.0025 0.0097 0.0096
Brugia malayi beta-lactamase family protein 0.004 0.0271 0.0271
Schistosoma mansoni chromobox protein 0.0078 0.0695 0.0695
Brugia malayi F/Y-rich N-terminus family protein 0.0018 0.0025 0.0025
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.031 0.1608
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.004 0.0271 0.0887
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0043 0.0307 0.2099
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.004 0.0271 0.0887
Onchocerca volvulus 0.004 0.0271 0.0952
Echinococcus granulosus lysosomal alpha glucosidase 0.0171 0.1748 0.1748
Brugia malayi Guanylyl cyclase protein 23 0.0025 0.0097 0.0097
Echinococcus granulosus atrial natriuretic peptide receptor 0.0025 0.0097 0.0096
Echinococcus multilocularis neuroligin 0.0152 0.1539 0.1538
Plasmodium falciparum thioredoxin reductase 0.0037 0.0232 0.1525
Brugia malayi Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog 0.0176 0.1809 0.1809
Loa Loa (eye worm) hypothetical protein 0.0152 0.1539 0.1539
Loa Loa (eye worm) hypothetical protein 0.0161 0.1633 0.1633
Echinococcus multilocularis glutamate receptor NMDA 0.0255 0.27 0.27
Schistosoma mansoni neuroligin 3 (S09 family) 0.0152 0.1539 0.1538
Echinococcus multilocularis glutamate receptor subunit protein glur 0.0048 0.0361 0.0361
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0107 0.1032 0.1031
Echinococcus granulosus snurportin 1 0.0298 0.3184 0.3184
Brugia malayi Melibiase family protein 0.0072 0.0627 0.0627
Echinococcus multilocularis chromobox protein 1 0.0078 0.0695 0.0695
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.031 0.1608
Trichomonas vaginalis spcc417.12 protein, putative 0.0152 0.1539 0.8745
Toxoplasma gondii hypothetical protein 0.0134 0.1333 1
Echinococcus granulosus tyrosine kinase 0.0025 0.0097 0.0096
Schistosoma mansoni hypothetical protein 0.0875 0.97 0.97
Schistosoma mansoni glutamate receptor NMDA 0.0309 0.3303 0.3303
Loa Loa (eye worm) carboxylesterase 0.0152 0.1539 0.1539
Loa Loa (eye worm) hypothetical protein 0.003 0.0151 0.0151
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0074 0.024
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0047 0.0347 0.1365
Entamoeba histolytica transcription factor BTF3, putative 0.0039 0.0258 0.9005
Echinococcus multilocularis chromobox protein 1 0.0078 0.0695 0.0695
Echinococcus multilocularis FAD linked sulfhydryl oxidase ALR 0.0036 0.0219 0.0219
Brugia malayi Latrophilin receptor protein 2 0.0151 0.1528 0.1528
Schistosoma mansoni hypothetical protein 0.0151 0.1528 0.1528
Trichomonas vaginalis penicillin-binding protein, putative 0.004 0.0271 0.1386
Brugia malayi Carboxylesterase family protein 0.0152 0.1539 0.1539
Trypanosoma brucei hypothetical protein, conserved 0.004 0.0271 0.092
Schistosoma mansoni alpha-glucosidase 0.0147 0.1479 0.1479
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0187 0.1932 1
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0038 0.0246 0.0246
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0151 0.1528 0.1528
Echinococcus granulosus cpg binding protein 0.0063 0.0532 0.0532
Echinococcus multilocularis acetylcholinesterase 0.0902 1 1
Echinococcus multilocularis acetylcholinesterase 0.0902 1 1
Echinococcus multilocularis thioredoxin glutathione reductase 0.0037 0.0237 0.0237
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0034 0.0006
Echinococcus multilocularis carbonic anhydrase 0.0134 0.1333 0.1333
Entamoeba histolytica acetyltransferase, GNAT family 0.004 0.0266 0.9313
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.004 0.0271 0.0271
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.004 0.0271 0.0271
Plasmodium falciparum ataxin-2 like protein, putative 0.0055 0.0444 0.3157
Schistosoma mansoni glutamate receptor kainate 0.013 0.1285 0.1285
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0072 0.0627 0.0627
Entamoeba histolytica hypothetical protein 0.004 0.0271 0.9516
Schistosoma mansoni glutamate receptor AMPA 0.013 0.1285 0.1285
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0107 0.1032 0.1031
Echinococcus multilocularis NMDA receptor 0.0048 0.0361 0.0361
Trypanosoma brucei transcription factor BTF3, putative 0.0039 0.0258 0.0869
Brugia malayi CXXC zinc finger family protein 0.006 0.0494 0.0494
Loa Loa (eye worm) hypothetical protein 0.0025 0.0097 0.0097
Loa Loa (eye worm) hypothetical protein 0.0176 0.1809 0.1809
Plasmodium vivax thioredoxin reductase, putative 0.0037 0.0232 0.483
Loa Loa (eye worm) hypothetical protein 0.0055 0.0444 0.0444
Echinococcus granulosus importin subunit beta 1 0.0028 0.0134 0.0133
Trichomonas vaginalis maltase-glucoamylase, putative 0.0038 0.0246 0.1242
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0248 0.2616 0.2616
Schistosoma mansoni carbonic anhydrase-related 0.0134 0.1333 0.1333
Loa Loa (eye worm) hypothetical protein 0.0327 0.3512 0.3512
Trypanosoma brucei ERV/ALR sulfhydryl oxidase domain-containing protein 0.0036 0.0219 0.0718
Leishmania major hypothetical protein, conserved 0.004 0.0271 0.092
Echinococcus multilocularis musashi 0.003 0.0158 0.0157
Echinococcus multilocularis carboxylesterase 5A 0.0902 1 1
Loa Loa (eye worm) inositol-1 0.0041 0.0283 0.0283
Trypanosoma cruzi transcription factor btf3, putative 0.0039 0.0258 0.0869
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0246 0.1242
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0155 0.1563 0.1563
Loa Loa (eye worm) hypothetical protein 0.004 0.0271 0.0271
Brugia malayi Glutamate receptor 1 precursor 0.013 0.1285 0.1285
Echinococcus granulosus glutamate receptor subunit protein glur 0.0048 0.0361 0.0361
Plasmodium falciparum carbonic anhydrase 0.0134 0.1333 1
Loa Loa (eye worm) hypothetical protein 0.0479 0.5222 0.5222
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0019 0.0027 0.0027
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0026 0.0115 0.0477
Trichomonas vaginalis inositol monophosphatase, putative 0.0041 0.0283 0.1454
Loa Loa (eye worm) CXXC zinc finger family protein 0.006 0.0494 0.0494
Brugia malayi Glutamate receptor 2 precursor 0.013 0.1285 0.1285
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0246 0.1242
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0152 0.1539 0.1538
Echinococcus multilocularis para nitrobenzyl esterase 0.0152 0.1539 0.1538
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0041 0.0283 0.0965
Toxoplasma gondii NAC domain-containing protein 0.0039 0.0258 0.1727
Brugia malayi Intermediate filament tail domain containing protein 0.003 0.0158 0.0158
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0084 0.0762 0.2718
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0074 0.0156
Schistosoma mansoni inositol monophosphatase 0.0041 0.0283 0.0283
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0025 0.0099 0.0099
Onchocerca volvulus 0.0152 0.1539 0.7859
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0041 0.0283 0.0965
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.005 0.0382 0.0382
Schistosoma mansoni carbonic anhydrase-related 0.0134 0.1333 0.1333
Brugia malayi Metabotropic glutamate receptor precursor. 0.0025 0.0097 0.0097
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0298 0.3184 0.3184
Trichomonas vaginalis ran, putative 0.0021 0.005 0.0103
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0043 0.0307 0.2099
Schistosoma mansoni transcription factor LCR-F1 0.004 0.0271 0.0271
Schistosoma mansoni cpg binding protein 0.006 0.0494 0.0493
Leishmania major extracellular receptor, putative 0.0025 0.0097 0.0243

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 0.8 nM Inhibition of recombinant human carbonic anhydrase 12 preincubated for 15 mins by stopped-flow CO2 hydrase Assay ChEMBL. 25147616
Ki (binding) = 5.3 nM Inhibition of recombinant human carbonic anhydrase 9 preincubated for 15 mins by stopped-flow CO2 hydrase Assay ChEMBL. 25147616
Ki (binding) = 98.1 nM Inhibition of recombinant human carbonic anhydrase 2 preincubated for 15 mins by stopped-flow CO2 hydrase Assay ChEMBL. 25147616
Ki (binding) = 416 nM Inhibition of recombinant human carbonic anhydrase 1 preincubated for 15 mins by stopped-flow CO2 hydrase Assay ChEMBL. 25147616

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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