Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Serotonin 1a (5-HT1a) receptor | Starlite/ChEMBL | References |
Rattus norvegicus | Serotonin 2a (5-HT2a) receptor | Starlite/ChEMBL | References |
Rattus norvegicus | Dopamine D2 receptor | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | sphingolipid delta 4 desaturase, putative | 0.0295 | 0.1991 | 0.1991 |
Brugia malayi | acyl-CoA desaturase | 0.1116 | 0.7884 | 1 |
Echinococcus multilocularis | Peptidase M, neutral zinc metallopeptidases, zinc binding site | 0.0295 | 0.1991 | 1 |
Trypanosoma brucei | delta-4 fatty acid desaturase | 0.0295 | 0.1991 | 0.1991 |
Loa Loa (eye worm) | hypothetical protein | 0.0156 | 0.0993 | 0.1259 |
Loa Loa (eye worm) | FAT-3 protein | 0.0295 | 0.1991 | 0.2525 |
Leishmania major | delta-6 fatty acid desaturase | 0.0295 | 0.1991 | 0.1991 |
Loa Loa (eye worm) | fatty acid desaturase | 0.0295 | 0.1991 | 0.2525 |
Trypanosoma brucei | cytochrome b5-dependent oleate desaturase | 0.0295 | 0.1991 | 0.1991 |
Leishmania major | fatty acid desaturase, putative,sphingolipid delta 4 desaturase, putative | 0.0295 | 0.1991 | 0.1991 |
Mycobacterium ulcerans | hypothetical protein | 0.0295 | 0.1991 | 1 |
Brugia malayi | Fatty acid desaturase family protein | 0.0295 | 0.1991 | 0.2525 |
Leishmania major | delta-4 fatty acid desaturase | 0.0295 | 0.1991 | 0.1991 |
Trypanosoma cruzi | fatty acid desaturase, putative | 0.0295 | 0.1991 | 0.1991 |
Toxoplasma gondii | sphingolipid delta 4 desaturase/c-4 hydroxylase protein des2 family protein | 0.0295 | 0.1991 | 0.5 |
Trypanosoma cruzi | fatty acid desaturase, putative | 0.0295 | 0.1991 | 0.1991 |
Echinococcus granulosus | Fatty acid desaturase type 1 | 0.0295 | 0.1991 | 1 |
Trypanosoma cruzi | fatty acid desaturase, putative | 0.1116 | 0.7884 | 0.7884 |
Mycobacterium ulcerans | transmembrane alkane 1-monooxygenase AlkB | 0.0295 | 0.1991 | 1 |
Mycobacterium ulcerans | linoleoyl-CoA desaturase, DesA3 | 0.0295 | 0.1991 | 1 |
Mycobacterium tuberculosis | Probable conserved membrane protein | 0.0295 | 0.1991 | 0.5 |
Trypanosoma cruzi | delta-4 fatty acid desaturase, putative | 0.0295 | 0.1991 | 0.1991 |
Trypanosoma cruzi | fatty acid desaturase, putative | 0.1116 | 0.7884 | 0.7884 |
Echinococcus multilocularis | Fatty acid desaturase, type 1 | 0.0295 | 0.1991 | 1 |
Loa Loa (eye worm) | fatty acid desaturase | 0.0295 | 0.1991 | 0.2525 |
Trypanosoma cruzi | sphingolipid delta 4 desaturase, putative | 0.0295 | 0.1991 | 0.1991 |
Echinococcus granulosus | Sphingolipid delta4 desaturase DES1 | 0.0295 | 0.1991 | 1 |
Leishmania major | fatty acid desaturase, putative | 0.0295 | 0.1991 | 0.1991 |
Echinococcus multilocularis | Peptidase M, neutral zinc metallopeptidases, zinc binding site | 0.0295 | 0.1991 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0156 | 0.0993 | 0.1259 |
Onchocerca volvulus | 0.141 | 1 | 1 | |
Trypanosoma cruzi | cytochrome b5-dependent oleate desaturase | 0.0295 | 0.1991 | 0.1991 |
Plasmodium falciparum | stearoyl-CoA desaturase | 0.1116 | 0.7884 | 0.5 |
Loa Loa (eye worm) | acyl-CoA desaturase | 0.1116 | 0.7884 | 1 |
Trypanosoma brucei | fatty acid desaturase, putative | 0.141 | 1 | 1 |
Trypanosoma cruzi | fatty acid desaturase, putative | 0.141 | 1 | 1 |
Leishmania major | fatty acid desaturase, putative,sphingolipid delta 4 desaturase, putative | 0.0295 | 0.1991 | 0.1991 |
Mycobacterium ulcerans | linoleoyl-CoA desaturase, DesA3 | 0.0295 | 0.1991 | 1 |
Leishmania major | fatty acid desaturase, putative | 0.0295 | 0.1991 | 0.1991 |
Mycobacterium ulcerans | electron transfer protein FdxB | 0.0295 | 0.1991 | 1 |
Trypanosoma cruzi | delta-4 fatty acid desaturase, putative | 0.0295 | 0.1991 | 0.1991 |
Onchocerca volvulus | 0.141 | 1 | 1 | |
Leishmania major | delta-12 fatty acid desaturase | 0.0295 | 0.1991 | 0.1991 |
Mycobacterium ulcerans | linoleoyl-CoA desaturase, DesA3_2 | 0.0295 | 0.1991 | 1 |
Trypanosoma brucei | delta-6 fatty acid desaturase, putative | 0.0295 | 0.1991 | 0.1991 |
Leishmania major | delta-5 fatty acid desaturase | 0.0295 | 0.1991 | 0.1991 |
Mycobacterium tuberculosis | Possible electron transfer protein FdxB | 0.0295 | 0.1991 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0295 | 0.1991 | 0.2525 |
Leishmania major | fatty-acid desaturase, putative | 0.141 | 1 | 1 |
Leishmania major | fatty acid desaturase, putative,sphingolipid delta 4 desaturase, putative | 0.0295 | 0.1991 | 0.1991 |
Mycobacterium tuberculosis | Probable transmembrane alkane 1-monooxygenase AlkB (alkane 1-hydroxylase) (lauric acid omega-hydroxylase) (omega-hydroxylase) (f | 0.0295 | 0.1991 | 0.5 |
Plasmodium vivax | stearoyl-CoA desaturase (acyl-CoA desaturase, faty acid desaturase), putative | 0.1116 | 0.7884 | 0.5 |
Brugia malayi | Fatty acid desaturase family protein | 0.0295 | 0.1991 | 0.2525 |
Mycobacterium ulcerans | hypothetical protein | 0.0295 | 0.1991 | 1 |
Schistosoma mansoni | fatty acid desaturase | 0.0295 | 0.1991 | 1 |
Leishmania major | fatty acid desaturase, putative,sphingolipid delta 4 desaturase, putative | 0.0295 | 0.1991 | 0.1991 |
Brugia malayi | Delta5 fatty acid desaturase | 0.0295 | 0.1991 | 0.2525 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Functional profile (functional) | Ability of the compound inhibit symptoms induced by 8-OH-DPAT was regarded as postsynaptic 5-HT1A receptor antagonistic activity; Antagonist | ChEMBL. | 15115407 | |
Functional profile (functional) | The ability to antagonize head twitches in mice, observed after administration of (+/-)- DOI, was used to evaluate 5-HT2A receptor antagonistic property; Antagonist | ChEMBL. | 15115407 | |
Ki (binding) | nM | Ability to bind to alpha-1 adrenergic receptor in vitro in cortex of the rat brain using [3H]-prazosin; Not determined | ChEMBL. | 15115407 |
Ki (binding) | = 64 nM | Ability to bind to central serotonin 5-hydroxytryptamine 2A receptor in vitro in cortex of the rat brain using [3H]-ketanserin radioligand | ChEMBL. | 15115407 |
Ki (binding) | = 68 nM | Ability to bind to central serotonin 5-hydroxytryptamine 1A receptor in vitro in hippocampus of the rat brain using [3H]-8-OH-DPAT radioligand | ChEMBL. | 15115407 |
Ki (binding) | = 165 nM | Ability to bind to Dopamine receptor D2 in vitro in rat sriatal membranes using [3H]-spiperone radioligand | ChEMBL. | 15115407 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.