Detailed information for compound 930627

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 349.426 | Formula: C21H23N3O2
  • H donors: 2 H acceptors: 3 LogP: 3.22 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: ONC(=O)CCCCc1ccn(n1)Cc1ccc(cc1)c1ccccc1
  • InChi: 1S/C21H23N3O2/c25-21(23-26)9-5-4-8-20-14-15-24(22-20)16-17-10-12-19(13-11-17)18-6-2-1-3-7-18/h1-3,6-7,10-15,26H,4-5,8-9,16H2,(H,23,25)
  • InChiKey: GIMAODGURWKHJY-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens histone deacetylase 10 Starlite/ChEMBL References
Homo sapiens histone deacetylase 3 Starlite/ChEMBL References
Homo sapiens histone deacetylase 2 Starlite/ChEMBL References
Homo sapiens histone deacetylase 11 Starlite/ChEMBL References
Homo sapiens histone deacetylase 8 Starlite/ChEMBL References
Homo sapiens histone deacetylase 6 Starlite/ChEMBL References
Homo sapiens histone deacetylase 1 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Candida albicans one of two distinct genes with strong similarity to S. cerevisiae RPD3 (YNL330C) SIN3 histone deacetylase complex component Get druggable targets OG5_126742 All targets in OG5_126742
Leishmania mexicana histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Trypanosoma brucei histone deacetylase 1 Get druggable targets OG5_126742 All targets in OG5_126742
Leishmania donovani histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Neospora caninum hypothetical protein Get druggable targets OG5_126654 All targets in OG5_126654
Echinococcus multilocularis histone deacetylase 3 Get druggable targets OG5_126742 All targets in OG5_126742
Loa Loa (eye worm) histone deacetylase 1 Get druggable targets OG5_126742 All targets in OG5_126742
Schistosoma japonicum Histone deacetylase 10, putative Get druggable targets OG5_126654 All targets in OG5_126654
Plasmodium vivax histone deacetylase 1, putative Get druggable targets OG5_126742 All targets in OG5_126742
Schistosoma japonicum hypothetical protein Get druggable targets OG5_126654 All targets in OG5_126654
Echinococcus multilocularis histone deacetylase Get druggable targets OG5_126654 All targets in OG5_126654
Schistosoma japonicum IPR000286,Histone deacetylase superfamily;IPR013838,Beta tubulin, autoregulation binding site,domain-containing Get druggable targets OG5_126654 All targets in OG5_126654
Entamoeba histolytica histone deacetylase, putative Get druggable targets OG5_126742 All targets in OG5_126742
Candida albicans one of two distinct genes with strong similarity to S. cerevisiae RPD3 (YNL330C) SIN3 histone deacetylase complex component Get druggable targets OG5_126742 All targets in OG5_126742
Brugia malayi Histone deacetylase family protein Get druggable targets OG5_126654 All targets in OG5_126654
Echinococcus granulosus histone deacetylase 3 Get druggable targets OG5_126742 All targets in OG5_126742
Leishmania infantum histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Leishmania donovani histone deacetylase, putative Get druggable targets OG5_126742 All targets in OG5_126742
Echinococcus multilocularis histone deacetylase 7 Get druggable targets OG5_126654 All targets in OG5_126654
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126742 All targets in OG5_126742
Plasmodium yoelii histone deacetylase/AcuC/AphA family protein, putative Get druggable targets OG5_129938 All targets in OG5_129938
Plasmodium berghei histone deacetylase 1, putative Get druggable targets OG5_126742 All targets in OG5_126742
Plasmodium knowlesi histone deacetylase 1, putative Get druggable targets OG5_126742 All targets in OG5_126742
Trypanosoma brucei histone deacetylase 4 Get druggable targets OG5_126654 All targets in OG5_126654
Plasmodium falciparum histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Leishmania infantum histone deacetylase, putative Get druggable targets OG5_126742 All targets in OG5_126742
Leishmania braziliensis histone deacetylase, putative Get druggable targets OG5_126742 All targets in OG5_126742
Trypanosoma cruzi histone deacetylase 1, putative Get druggable targets OG5_126742 All targets in OG5_126742
Trypanosoma congolense histone deacetylase 4 Get druggable targets OG5_126654 All targets in OG5_126654
Schistosoma mansoni histone deacetylase Get druggable targets OG5_126742 All targets in OG5_126742
Plasmodium knowlesi histone deacetylase, putative Get druggable targets OG5_129938 All targets in OG5_129938
Leishmania braziliensis histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Leishmania major histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Schistosoma japonicum Histone deacetylase 6, putative Get druggable targets OG5_126654 All targets in OG5_126654
Trypanosoma congolense histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_129938 All targets in OG5_129938
Brugia malayi histone deacetylase 1 (HD1) Get druggable targets OG5_126742 All targets in OG5_126742
Leishmania major histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126654 All targets in OG5_126654
Plasmodium falciparum histone deacetylase 1 Get druggable targets OG5_126742 All targets in OG5_126742
Loa Loa (eye worm) histone deacetylase 11 Get druggable targets OG5_129938 All targets in OG5_129938
Schistosoma japonicum Histone deacetylase 10, putative Get druggable targets OG5_126654 All targets in OG5_126654
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126654 All targets in OG5_126654
Toxoplasma gondii histone deacetylase HDAC3 Get druggable targets OG5_126742 All targets in OG5_126742
Cryptosporidium hominis histone deacetylase Get druggable targets OG5_126742 All targets in OG5_126742
Babesia bovis histone deacetylase Get druggable targets OG5_126742 All targets in OG5_126742
Neospora caninum histone deacetylase, putative Get druggable targets OG5_126742 All targets in OG5_126742
Trichomonas vaginalis histone deacetylase, putative Get druggable targets OG5_126742 All targets in OG5_126742
Echinococcus multilocularis histone deacetylase 1 Get druggable targets OG5_126742 All targets in OG5_126742
Trypanosoma brucei gambiense histone deacetylase 1,histone deacetylase-like 1 protein, putative Get druggable targets OG5_126742 All targets in OG5_126742
Trypanosoma brucei histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Leishmania mexicana histone deacetylase, putative Get druggable targets OG5_126742 All targets in OG5_126742
Loa Loa (eye worm) histone deacetylase 3 Get druggable targets OG5_126742 All targets in OG5_126742
Toxoplasma gondii histone deacetylase HDAC1 Get druggable targets OG5_126654 All targets in OG5_126654
Leishmania infantum histone deacetylase, putative Get druggable targets OG5_126742 All targets in OG5_126742
Trypanosoma congolense histone deacetylase-like 1 protein, putative Get druggable targets OG5_126742 All targets in OG5_126742
Loa Loa (eye worm) histone deacetylase Get druggable targets OG5_126654 All targets in OG5_126654
Toxoplasma gondii histone deacetylase HDAC4 Get druggable targets OG5_129938 All targets in OG5_129938
Plasmodium yoelii histone deacetylase Get druggable targets OG5_126742 All targets in OG5_126742
Trypanosoma brucei histone deacetylase 3 Get druggable targets OG5_126654 All targets in OG5_126654
Cryptosporidium hominis hypothetical protein Get druggable targets OG5_126654 All targets in OG5_126654
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative Get druggable targets OG5_126742 All targets in OG5_126742
Schistosoma japonicum Histone deacetylase 6, putative Get druggable targets OG5_126654 All targets in OG5_126654
Schistosoma mansoni histone deacetylase 4 5 Get druggable targets OG5_126654 All targets in OG5_126654
Trichomonas vaginalis histone deacetylase, putative Get druggable targets OG5_126742 All targets in OG5_126742
Cryptosporidium parvum histone deactylase of possible bacterial origin with ankyrin repeats at the N-terminus Get druggable targets OG5_126654 All targets in OG5_126654
Candida albicans one of two distinct genes with strong similarity to S. cerevisiae RPD3 (YNL330C) SIN3 histone deacetylase complex component Get druggable targets OG5_126742 All targets in OG5_126742
Theileria parva histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Neospora caninum hypothetical protein Get druggable targets OG5_126742 All targets in OG5_126742
Leishmania braziliensis histone deacetylase, putative Get druggable targets OG5_126742 All targets in OG5_126742
Candida albicans strong similarity to S. cerevisiae HDA1 (YNL021W) class II histone deacetylase HDA1 complex subunit Get druggable targets OG5_126654 All targets in OG5_126654
Leishmania braziliensis histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Trichomonas vaginalis histone deacetylase, putative Get druggable targets OG5_126742 All targets in OG5_126742
Echinococcus granulosus histone deacetylase 6 Get druggable targets OG5_126654 All targets in OG5_126654
Theileria parva histone deacetylase, putative Get druggable targets OG5_126742 All targets in OG5_126742
Echinococcus granulosus histone deacetylase Get druggable targets OG5_126654 All targets in OG5_126654
Echinococcus multilocularis histone deacetylase 6 Get druggable targets OG5_126654 All targets in OG5_126654
Plasmodium vivax histone deacetylase 2, putative Get druggable targets OG5_126654 All targets in OG5_126654
Schistosoma mansoni histone deacetylase 4 5 Get druggable targets OG5_126654 All targets in OG5_126654
Toxoplasma gondii histone deacetylase HDAC2 Get druggable targets OG5_126742 All targets in OG5_126742
Schistosoma mansoni histone deacetylase Get druggable targets OG5_126742 All targets in OG5_126742
Candida albicans strong similarity to S. cerevisiae HDA1 (YNL021W) class II histone deacetylase HDA1 complex subunit Get druggable targets OG5_126654 All targets in OG5_126654
Giardia lamblia Histone deacetylase Get druggable targets OG5_126742 All targets in OG5_126742
Leishmania donovani histone deacetylase, putative Get druggable targets OG5_126742 All targets in OG5_126742
Echinococcus granulosus histone deacetylase 1 Get druggable targets OG5_126742 All targets in OG5_126742
Theileria parva hypothetical protein Get druggable targets OG5_126654 All targets in OG5_126654
Cryptosporidium hominis histone deacetylase Get druggable targets OG5_126742 All targets in OG5_126742
Echinococcus multilocularis histone deacetylase 6 Get druggable targets OG5_126654 All targets in OG5_126654
Theileria parva hypothetical protein Get druggable targets OG5_126654 All targets in OG5_126654
Plasmodium vivax histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Trypanosoma cruzi histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Trichomonas vaginalis histone deacetylase, putative Get druggable targets OG5_126742 All targets in OG5_126742
Cryptosporidium parvum histone deacetylase HDA2/Rpd3p Get druggable targets OG5_126742 All targets in OG5_126742
Loa Loa (eye worm) histone deacetylase 7A Get druggable targets OG5_126654 All targets in OG5_126654
Candida albicans one of two distinct genes with strong similarity to S. cerevisiae RPD3 (YNL330C) SIN3 histone deacetylase complex component Get druggable targets OG5_126742 All targets in OG5_126742
Plasmodium falciparum histone deacetylase 2 Get druggable targets OG5_126654 All targets in OG5_126654
Schistosoma japonicum Histone deacetylase 4, putative Get druggable targets OG5_126654 All targets in OG5_126654
Brugia malayi histone deacetylase 11 Get druggable targets OG5_129938 All targets in OG5_129938
Schistosoma japonicum ko:K01463 Hdac3 [EC:3.5.1.-], putative Get druggable targets OG5_126742 All targets in OG5_126742
Leishmania mexicana histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Leishmania infantum histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Schistosoma mansoni histone deacetylase hda2 Get druggable targets OG5_126654 All targets in OG5_126654
Trichomonas vaginalis histone deacetylase, putative Get druggable targets OG5_126742 All targets in OG5_126742
Trypanosoma cruzi histone deacetylase 1, putative Get druggable targets OG5_126742 All targets in OG5_126742
Leishmania major histone deacetylase, putative Get druggable targets OG5_126742 All targets in OG5_126742
Plasmodium yoelii hypothetical protein Get druggable targets OG5_126654 All targets in OG5_126654
Trypanosoma brucei gambiense histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Trypanosoma congolense histone deacetylase 4 Get druggable targets OG5_126654 All targets in OG5_126654
Trichomonas vaginalis histone deacetylase, putative Get druggable targets OG5_126742 All targets in OG5_126742
Leishmania mexicana histone deacetylase, putative Get druggable targets OG5_126742 All targets in OG5_126742
Schistosoma japonicum Histone deacetylase 4, putative Get druggable targets OG5_126654 All targets in OG5_126654
Neospora caninum hypothetical protein Get druggable targets OG5_129938 All targets in OG5_129938
Trypanosoma cruzi histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Plasmodium berghei histone deacetylase, putative Get druggable targets OG5_129938 All targets in OG5_129938
Plasmodium berghei histone deacetylase 2, putative Get druggable targets OG5_126654 All targets in OG5_126654
Echinococcus granulosus histone deacetylase 6 Get druggable targets OG5_126654 All targets in OG5_126654
Echinococcus granulosus histone deacetylase 7 Get druggable targets OG5_126654 All targets in OG5_126654
Plasmodium knowlesi histone deacetylase 2, putative Get druggable targets OG5_126654 All targets in OG5_126654
Plasmodium yoelii Histone deacetylase family, putative Get druggable targets OG5_126654 All targets in OG5_126654
Leishmania major histone deacetylase, putative Get druggable targets OG5_126742 All targets in OG5_126742
Trypanosoma cruzi histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Plasmodium vivax histone deacetylase, putative Get druggable targets OG5_129938 All targets in OG5_129938
Babesia bovis histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Brugia malayi Histone deacetylase 1 Get druggable targets OG5_126742 All targets in OG5_126742
Plasmodium knowlesi histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Echinococcus granulosus histone deacetylase 6 Get druggable targets OG5_126654 All targets in OG5_126654
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative Get druggable targets OG5_126742 All targets in OG5_126742
Leishmania donovani histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Cryptosporidium parvum RPD3/HD1 histone deacetylase Get druggable targets OG5_126742 All targets in OG5_126742
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative Get druggable targets OG5_126742 All targets in OG5_126742
Echinococcus multilocularis histone deacetylase 6 Get druggable targets OG5_126654 All targets in OG5_126654
Brugia malayi histone deacetylase 3 (HD3) Get druggable targets OG5_126742 All targets in OG5_126742
Plasmodium berghei histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Brugia malayi Histone deacetylase family protein Get druggable targets OG5_126654 All targets in OG5_126654
Schistosoma japonicum ko:K06067 histone deacetylase 1/2, putative Get druggable targets OG5_126742 All targets in OG5_126742
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi Histone deacetylase family protein histone deacetylase 11 296 aa 290 aa 24.5 %
Trypanosoma brucei histone deacetylase 2 histone deacetylase 2 488 aa 427 aa 29.0 %
Plasmodium falciparum histone deacetylase 1 histone deacetylase 8 286 aa 241 aa 44.8 %
Trypanosoma cruzi histone deacetylase, putative histone deacetylase 3 428 aa 374 aa 30.5 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi SH2 domain containing protein 0.0132 0.2581 0.3067
Entamoeba histolytica protein kinase, putative 0.0071 0.099 0.1242
Schistosoma mansoni apoptosis stimulating of P53 0.0123 0.2347 0.2347
Entamoeba histolytica BAR/SH3 domain containing protein 0.0123 0.2347 0.3143
Brugia malayi Protein kinase domain containing protein 0.0037 0.0105 0.0124
Schistosoma mansoni serine/threonine protein kinase 0.0052 0.0503 0.0503
Echinococcus multilocularis SHC transforming protein 3 0.0132 0.2581 0.2581
Schistosoma mansoni adapter molecule crk 0.0255 0.5791 0.5791
Schistosoma mansoni vav2 0.0142 0.2827 0.2827
Plasmodium falciparum protein kinase 5 0.0052 0.0503 0.0559
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0037 0.0105 0.0105
Loa Loa (eye worm) TK/INSR protein kinase 0.0037 0.0105 0.0124
Schistosoma mansoni histone deacetylase 1 2 3 0.0146 0.2946 0.2946
Schistosoma mansoni ephrin receptor 0.0037 0.0105 0.0105
Onchocerca volvulus 0.0132 0.2581 0.5621
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0052 0.0503 0.0598
Loa Loa (eye worm) TK protein kinase 0.0203 0.4434 0.5268
Echinococcus granulosus histone deacetylase 3 0.0311 0.7241 0.7241
Loa Loa (eye worm) hypothetical protein 0.021 0.4609 0.5475
Echinococcus granulosus tyrosine protein kinase csk 0.0074 0.1067 0.1067
Trypanosoma cruzi cdc2-related kinase 3 0.0052 0.0503 0.0559
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0139 0.2765 0.2765
Loa Loa (eye worm) AGC/PKC/ALPHA protein kinase 0.005 0.0443 0.0526
Echinococcus multilocularis SH2 domain containing protein 7 0.0132 0.2581 0.2581
Loa Loa (eye worm) hypothetical protein 0.0037 0.0105 0.0124
Trichomonas vaginalis conserved hypothetical protein 0.0123 0.2347 0.3143
Entamoeba histolytica hypothetical protein 0.0123 0.2347 0.3143
Brugia malayi SH2 domain containing protein 0.0132 0.2581 0.3067
Echinococcus multilocularis protein kinase 0.0037 0.0105 0.0105
Loa Loa (eye worm) TK/ROR protein kinase 0.0037 0.0105 0.0124
Schistosoma mansoni shc transforming protein 0.0132 0.2581 0.2581
Toxoplasma gondii histone deacetylase HDAC5 0.0146 0.2946 0.3418
Echinococcus granulosus cyclin dependent kinase 5 0.0052 0.0503 0.0503
Echinococcus multilocularis serine threonine protein kinase 0.0072 0.1015 0.1015
Echinococcus multilocularis epidermal growth factor receptor 0.0037 0.0105 0.0105
Echinococcus granulosus histone deacetylase 1 0.0311 0.7241 0.7241
Brugia malayi Protein kinase domain containing protein 0.0037 0.0105 0.0124
Brugia malayi Protein kinase domain containing protein 0.0037 0.0105 0.0124
Loa Loa (eye worm) TK protein kinase 0.0037 0.0105 0.0124
Brugia malayi Protein kinase domain containing protein 0.0037 0.0105 0.0124
Schistosoma mansoni histone deacetylase 4 5 0.0231 0.5162 0.5162
Loa Loa (eye worm) hypothetical protein 0.0037 0.0105 0.0124
Schistosoma mansoni protein kinase 0.0037 0.0105 0.0105
Echinococcus granulosus fibroblast growth factor receptor 4 0.0037 0.0105 0.0105
Schistosoma mansoni tensin-related 0.0132 0.2581 0.2581
Trypanosoma brucei conserved protein 0.0123 0.2347 0.3143
Trichomonas vaginalis histone deacetylase, putative 0.0311 0.7241 1
Onchocerca volvulus 0.0132 0.2581 0.5621
Echinococcus multilocularis tyrosine protein kinase Abl 0.0292 0.6758 0.6758
Onchocerca volvulus 0.0132 0.2581 0.5621
Schistosoma mansoni serine/threonine protein kinase 0.0044 0.0288 0.0288
Plasmodium vivax protein kinase Crk2 0.0052 0.0503 0.048
Echinococcus multilocularis protein KINase family member (kin 25) 0.0037 0.0105 0.0105
Brugia malayi Protein kinase domain containing protein 0.0037 0.0105 0.0124
Loa Loa (eye worm) SH2 domain-containing protein 0.0132 0.2581 0.3067
Loa Loa (eye worm) hypothetical protein 0.0146 0.2946 0.35
Echinococcus granulosus growth factor receptor bound protein 2 0.0255 0.5791 0.5791
Loa Loa (eye worm) TK/FER protein kinase 0.0037 0.0105 0.0124
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0292 0.6758 0.6758
Echinococcus multilocularis suppressor of cytokine signaling 7 0.0132 0.2581 0.2581
Leishmania major histone deacetylase, putative 0.0311 0.7241 1
Echinococcus granulosus tyrosine protein kinase Fyn 0.0327 0.7644 0.7644
Entamoeba histolytica histone deacetylase, putative 0.0311 0.7241 1
Brugia malayi Tensin 0.0132 0.2581 0.3067
Entamoeba histolytica protein kinase, putative 0.0051 0.0463 0.0503
Loa Loa (eye worm) hypothetical protein 0.0132 0.2581 0.3067
Schistosoma mansoni suppressor of cytokine signaling 0.0132 0.2581 0.2581
Echinococcus granulosus Spectrin alpha actinin 0.0123 0.2347 0.2347
Brugia malayi Variant SH3 domain containing protein 0.0255 0.5791 0.6879
Echinococcus granulosus activated cdc42 kinase 1 0.0037 0.0105 0.0105
Trypanosoma brucei rac serine-threonine kinase, putative 0.0051 0.0463 0.0503
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0037 0.0105 0.0124
Toxoplasma gondii histone deacetylase HDAC4 0.0356 0.8418 1
Echinococcus multilocularis tyrosine kinase 0.0169 0.3548 0.3548
Loa Loa (eye worm) hypothetical protein 0.0135 0.2644 0.3141
Echinococcus multilocularis mitogen activated protein kinase 0.0062 0.0741 0.0741
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0037 0.0105 0.0105
Loa Loa (eye worm) TK/FER protein kinase 0.0037 0.0105 0.0124
Echinococcus granulosus activated cdc42 kinase 1 0.0037 0.0105 0.0105
Loa Loa (eye worm) TK/FER protein kinase 0.0037 0.0105 0.0124
Echinococcus granulosus dual specificity testis-specific protein kinase 0.004 0.0173 0.0173
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0169 0.3548 0.3548
Echinococcus granulosus rho guanine nucleotide exchange factor 7 0.0123 0.2347 0.2347
Brugia malayi Protein kinase domain containing protein 0.0037 0.0105 0.0124
Loa Loa (eye worm) TK/FER protein kinase 0.0169 0.3548 0.4215
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.0503 0.0559
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0311 0.7241 1
Schistosoma mansoni tyrosine kinase 0.0037 0.0105 0.0105
Brugia malayi SH2 domain containing protein 0.0132 0.2581 0.3067
Brugia malayi Adenylate and Guanylate cyclase catalytic domain containing protein 0.0037 0.0105 0.0124
Loa Loa (eye worm) protein-tyrosine kinase 0.0123 0.2347 0.2788
Trichomonas vaginalis STE family protein kinase 0.0089 0.1448 0.1883
Echinococcus granulosus N chimaerin 0.0139 0.2765 0.2765
Trichomonas vaginalis conserved hypothetical protein 0.0123 0.2347 0.3143
Brugia malayi Adenylate and Guanylate cyclase catalytic domain containing protein 0.0037 0.0105 0.0124
Toxoplasma gondii AGC kinase 0.0048 0.0401 0.0357
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0132 0.2581 0.2581
Loa Loa (eye worm) hypothetical protein 0.0037 0.0105 0.0124
Trypanosoma brucei protein kinase, putative 0.004 0.0173 0.0096
Schistosoma mansoni tyrosine kinase 0.0327 0.7644 0.7644
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0169 0.3548 0.3548
Schistosoma mansoni tyrosine-protein kinase fps85d 0.0037 0.0105 0.0105
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0037 0.0105 0.0105
Echinococcus granulosus mitogen activated protein kinase 0.0062 0.0741 0.0741
Trypanosoma cruzi paraflagellar rod protein 5, putative 0.0123 0.2347 0.3143
Echinococcus granulosus SH2 domain containing adapter protein F 0.0132 0.2581 0.2581
Loa Loa (eye worm) TK/FER protein kinase 0.0169 0.3548 0.4215
Schistosoma mansoni histone deacetylase hda2 0.0239 0.5356 0.5356
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0132 0.2581 0.2581
Loa Loa (eye worm) TK/EGFR protein kinase 0.0037 0.0105 0.0124
Loa Loa (eye worm) cytokine inducible SH2-containing protein 5 0.0132 0.2581 0.3067
Echinococcus multilocularis protein tyrosine kinase 0.0037 0.0105 0.0105
Entamoeba histolytica hypothetical protein 0.0123 0.2347 0.3143
Entamoeba histolytica protein kinase, putative 0.0051 0.0463 0.0503
Echinococcus granulosus tyrosine protein kinase Src64B 0.0327 0.7644 0.7644
Echinococcus granulosus tensin 0.0132 0.2581 0.2581
Schistosoma mansoni serine/threonine protein kinase 0.0037 0.0105 0.0105
Entamoeba histolytica protein kinase, putative 0.0048 0.0401 0.0415
Entamoeba histolytica BAR/SH3 domain containing protein 0.0123 0.2347 0.3143
Onchocerca volvulus LIM and SH3 domain protein homolog 0.0123 0.2347 0.509
Loa Loa (eye worm) thyroid receptor interactor 0.0123 0.2347 0.2788
Entamoeba histolytica hypothetical protein 0.0123 0.2347 0.3143
Echinococcus multilocularis c src tyrosine kinase 0.0329 0.772 0.772
Schistosoma mansoni tyrosine kinase 0.0037 0.0105 0.0105
Loa Loa (eye worm) hypothetical protein 0.0123 0.2347 0.2788
Leishmania major mitogen-activated protein kinase kinase 5, putative;with=GeneDB:LmxM36.0860 0.0089 0.1448 0.1883
Schistosoma mansoni Dab2-interacting protein-like 0.0123 0.2347 0.2347
Loa Loa (eye worm) TK/ACK protein kinase 0.0037 0.0105 0.0124
Schistosoma mansoni tensin 0.0132 0.2581 0.2581
Brugia malayi Protein kinase domain containing protein 0.0037 0.0105 0.0124
Trichomonas vaginalis conserved hypothetical protein 0.0123 0.2347 0.3143
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0052 0.0503 0.0559
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0327 0.7644 0.7644
Echinococcus multilocularis tyrosine protein kinase csk 0.0074 0.1067 0.1067
Loa Loa (eye worm) histone deacetylase 3 0.0311 0.7241 0.8602
Loa Loa (eye worm) TK/Met protein kinase 0.0037 0.0105 0.0124
Brugia malayi Variant SH3 domain containing protein 0.0123 0.2347 0.2788
Loa Loa (eye worm) TKL/RAF/KSR protein kinase 0.0037 0.0105 0.0124
Echinococcus granulosus protein tyrosine kinase 0.0037 0.0105 0.0105
Plasmodium falciparum histone deacetylase 1 0.0311 0.7241 1
Echinococcus granulosus SH2 domain containing protein 7 0.0132 0.2581 0.2581
Echinococcus multilocularis histone deacetylase 6 0.0231 0.5162 0.5162
Trypanosoma cruzi hypothetical protein, conserved 0.0123 0.2347 0.3143
Schistosoma mansoni tyrosine kinase 0.0037 0.0105 0.0105
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0255 0.5791 0.6879
Trichomonas vaginalis neutrophil cytosolic factor 2, neutrophil NADPH oxidase factor, putative 0.0123 0.2347 0.3143
Loa Loa (eye worm) RGC/RGC protein kinase 0.0037 0.0105 0.0124
Onchocerca volvulus Suppressor of cytokine signaling at 36E homolog 0.0132 0.2581 0.5621
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0135 0.265 0.3567
Schistosoma mansoni histone deacetylase hda2 0.0146 0.2946 0.2946
Entamoeba histolytica protein kinase domain containing protein 0.004 0.0173 0.0096
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0132 0.2581 0.3067
Onchocerca volvulus 0.0126 0.2416 0.5246
Echinococcus granulosus tyrosine protein kinase ABL1 0.0169 0.3548 0.3548
Echinococcus multilocularis hematopoietic lineage cell specific protein 0.0123 0.2347 0.2347
Loa Loa (eye worm) RhoGAP domain-containing protein 0.0139 0.2765 0.3285
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.0503 0.0559
Leishmania major histone deacetylase, putative 0.0231 0.5162 0.7087
Brugia malayi Protein kinase domain containing protein 0.0037 0.0105 0.0124
Schistosoma mansoni tensin 0.0132 0.2581 0.2581
Echinococcus multilocularis rho guanine nucleotide exchange factor 7 0.0123 0.2347 0.2347
Schistosoma mansoni tyrosine kinase 0.0037 0.0105 0.0105
Echinococcus multilocularis dual specificity mitogen activated protein 0.0089 0.1448 0.1448
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0052 0.0503 0.0598
Echinococcus granulosus suppressor of cytokine signaling 7 0.0132 0.2581 0.2581
Loa Loa (eye worm) TK/FER protein kinase 0.0169 0.3548 0.4215
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0327 0.7644 0.7644
Loa Loa (eye worm) TK/KIN6 protein kinase 0.0037 0.0105 0.0124
Brugia malayi hypothetical protein 0.0132 0.2581 0.3067
Entamoeba histolytica hypothetical protein 0.0123 0.2347 0.3143
Schistosoma mansoni hypothetical protein 0.0123 0.2347 0.2347
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0203 0.4434 0.4434
Echinococcus multilocularis SH2 motif 0.0132 0.2581 0.2581
Loa Loa (eye worm) hypothetical protein 0.0132 0.2581 0.3067
Echinococcus granulosus tyrosine protein kinase Srms 0.0169 0.3548 0.3548
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0327 0.7644 0.7644
Loa Loa (eye worm) STE/STE7/MEK1 protein kinase 0.0089 0.1448 0.172
Brugia malayi Protein kinase domain containing protein 0.0037 0.0105 0.0124
Brugia malayi SH2 domain containing protein 0.0132 0.2581 0.3067
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.0139 0.2765 0.2765
Schistosoma mansoni tyrosine-protein kinase zap-70 0.0132 0.2581 0.2581
Echinococcus multilocularis tyrosine protein kinase 0.0037 0.0105 0.0105
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0037 0.0105 0.0105
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0037 0.0105 0.0105
Echinococcus granulosus retinal guanylyl cyclase 2 0.0037 0.0105 0.0105
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0169 0.3548 0.4826
Loa Loa (eye worm) TK protein kinase 0.0037 0.0105 0.0124
Echinococcus granulosus protein kinase C gamma type 0.0072 0.1015 0.1015
Echinococcus multilocularis tensin 0.0132 0.2581 0.2581
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0052 0.0503 0.0598
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0037 0.0105 0.0105
Onchocerca volvulus 0.0132 0.2581 0.5621
Brugia malayi hypothetical protein 0.0037 0.0105 0.0124
Echinococcus multilocularis tyrosine protein kinase shark 0.0417 1 1
Echinococcus granulosus mitogen-activated protein kinase kinase kinase 9 0.0037 0.0105 0.0105
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0062 0.0741 0.0891
Brugia malayi Protein kinase domain containing protein 0.0037 0.0105 0.0124
Brugia malayi Tyrosine-protein kinase PR2 0.0037 0.0105 0.0124
Echinococcus multilocularis histone deacetylase 6 0.0239 0.5356 0.5356
Brugia malayi bone morphogenetic protein type 1 receptor 0.0037 0.0105 0.0124
Loa Loa (eye worm) histone deacetylase 7A 0.0231 0.5162 0.6132
Echinococcus granulosus SHC transforming protein 3 0.0132 0.2581 0.2581
Loa Loa (eye worm) p53BP2 0.0123 0.2347 0.2788
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0311 0.7241 1
Schistosoma mansoni slit-robo rho gtpase activating protein 0.0123 0.2347 0.2347
Echinococcus granulosus RNA directed DNA polymerase 0.0046 0.0336 0.0336
Brugia malayi cell division control protein 2 homolog 0.0052 0.0503 0.0598
Loa Loa (eye worm) hypothetical protein 0.0132 0.2581 0.3067
Loa Loa (eye worm) TKL/MLK/ILK protein kinase 0.0037 0.0105 0.0124
Loa Loa (eye worm) hypothetical protein 0.0132 0.2581 0.3067
Echinococcus multilocularis nostrin 0.0123 0.2347 0.2347
Brugia malayi Protein kinase domain containing protein 0.0037 0.0105 0.0124
Echinococcus granulosus endophilin A3 0.0123 0.2347 0.2347
Trypanosoma brucei histone deacetylase 4 0.0231 0.5162 0.7087
Plasmodium falciparum histone deacetylase 2 0.0231 0.5162 0.7087
Echinococcus multilocularis tyrosine protein kinase HCK 0.0071 0.099 0.099
Loa Loa (eye worm) RGC/RGC protein kinase 0.0037 0.0105 0.0124
Loa Loa (eye worm) SRC-1 0.0327 0.7644 0.908
Loa Loa (eye worm) hypothetical protein 0.0132 0.2581 0.3067
Brugia malayi Protein kinase domain containing protein 0.0051 0.0463 0.055
Trypanosoma cruzi histone deacetylase, putative 0.0231 0.5162 0.7087
Loa Loa (eye worm) TK protein kinase 0.0037 0.0105 0.0124
Schistosoma mansoni protein kinase 0.0089 0.1448 0.1448
Trypanosoma cruzi histone deacetylase, putative 0.0231 0.5162 0.7087
Brugia malayi STAT protein, DNA binding domain containing protein 0.0132 0.2581 0.3067
Schistosoma mansoni serine/threonine protein kinase 0.0062 0.0741 0.0741
Trichomonas vaginalis conserved hypothetical protein 0.0123 0.2347 0.3143
Plasmodium vivax histone deacetylase 1, putative 0.0311 0.7241 0.8584
Brugia malayi histone deacetylase 1 (HD1) 0.0311 0.7241 0.8602
Echinococcus multilocularis tyrosine protein kinase Srms 0.0203 0.4434 0.4434
Schistosoma mansoni hypothetical protein 0.0132 0.2581 0.2581
Loa Loa (eye worm) hypothetical protein 0.0053 0.052 0.0617
Onchocerca volvulus 0.0169 0.3548 0.7816
Leishmania major hypothetical protein, conserved 0.0123 0.2347 0.3143
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.0255 0.5791 0.5791
Entamoeba histolytica unconventional myosin IB 0.0123 0.2347 0.3143
Brugia malayi Histone deacetylase 1 0.0311 0.7241 0.8602
Trypanosoma brucei mitogen-activated protein kinase kinase 5 0.0089 0.1448 0.1883
Trichomonas vaginalis STE family protein kinase 0.0089 0.1448 0.1883
Loa Loa (eye worm) hypothetical protein 0.0123 0.2347 0.2788
Echinococcus multilocularis SH2 motif 0.0132 0.2581 0.2581
Onchocerca volvulus 0.0123 0.2347 0.509
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0327 0.7644 0.7644
Loa Loa (eye worm) hypothetical protein 0.0132 0.2581 0.3067
Toxoplasma gondii calcium dependent protein kinase CDPK8 0.004 0.0173 0.0083
Echinococcus granulosus tyrosine protein kinase csk 0.0074 0.1067 0.1067
Trypanosoma cruzi hypothetical protein, conserved 0.0123 0.2347 0.3143
Echinococcus granulosus tyrosine protein kinase csk 0.0074 0.1067 0.1067
Brugia malayi Tyrosine-protein kinase F09A5.2 in chromosome X, putative 0.0037 0.0105 0.0124
Echinococcus granulosus histone deacetylase 7 0.0231 0.5162 0.5162
Brugia malayi Protein kinase domain containing protein 0.0169 0.3548 0.4215
Echinococcus multilocularis fibroblast growth factor receptor 4 0.0037 0.0105 0.0105
Loa Loa (eye worm) TK/ABL protein kinase 0.0169 0.3548 0.4215
Schistosoma mansoni tyrosine kinase 0.0037 0.0105 0.0105
Entamoeba histolytica cell division protein kinase 2, putative 0.0052 0.0503 0.0559
Trichomonas vaginalis histone deacetylase, putative 0.0311 0.7241 1
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0311 0.7241 1
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0037 0.0105 0.0105
Echinococcus multilocularis heat shock protein 70 0.0037 0.0105 0.0105
Trichomonas vaginalis conserved hypothetical protein 0.0123 0.2347 0.3143
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0048 0.0401 0.0476
Loa Loa (eye worm) TK/FER protein kinase 0.0169 0.3548 0.4215
Entamoeba histolytica hypothetical protein, conserved 0.0123 0.2347 0.3143
Brugia malayi Src substrate cortactin 0.0123 0.2347 0.2788
Loa Loa (eye worm) TK protein kinase 0.0037 0.0105 0.0124
Loa Loa (eye worm) TK/FER protein kinase 0.0037 0.0105 0.0124
Entamoeba histolytica hypothetical protein 0.0123 0.2347 0.3143
Brugia malayi Protein kinase domain containing protein 0.0037 0.0105 0.0124
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0132 0.2581 0.3067
Echinococcus multilocularis intersectin 2 0.0125 0.2385 0.2385
Echinococcus granulosus fch and double sh3 domains protein 2 0.0123 0.2347 0.2347
Schistosoma mansoni tyrosine kinase 0.0037 0.0105 0.0105
Echinococcus multilocularis activin receptor type 0.004 0.0173 0.0173
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0062 0.0741 0.0891
Entamoeba histolytica hypothetical protein, conserved 0.0123 0.2347 0.3143
Toxoplasma gondii histone deacetylase HDAC3 0.0311 0.7241 0.8584
Loa Loa (eye worm) hypothetical protein 0.0255 0.5791 0.6879
Echinococcus multilocularis histone deacetylase 8 0.0146 0.2946 0.2946
Echinococcus granulosus tyrosine protein kinase Src42A 0.0327 0.7644 0.7644
Brugia malayi Protein kinase domain containing protein 0.0169 0.3548 0.4215
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.0503 0.0559
Trichomonas vaginalis AGC family protein kinase 0.0051 0.0463 0.0503
Schistosoma mansoni tyrosine kinase 0.0037 0.0105 0.0105
Schistosoma mansoni serine/threonine protein kinase 0.0079 0.1198 0.1198
Loa Loa (eye worm) hypothetical protein 0.0123 0.2347 0.2788
Loa Loa (eye worm) hypothetical protein 0.0311 0.7241 0.8602
Loa Loa (eye worm) TK/DDR protein kinase 0.0037 0.0105 0.0124
Loa Loa (eye worm) hypothetical protein 0.0132 0.2581 0.3067
Brugia malayi Protein kinase domain containing protein 0.0169 0.3548 0.4215
Schistosoma mansoni tensin 0.0132 0.2581 0.2581
Schistosoma mansoni tyrosine kinase 0.0037 0.0105 0.0105
Trichomonas vaginalis AGC family protein kinase 0.0051 0.0463 0.0503
Echinococcus multilocularis tensin 0.0132 0.2581 0.2581
Brugia malayi Immunoglobulin I-set domain containing protein 0.0037 0.0105 0.0124
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0327 0.7644 0.7644
Onchocerca volvulus 0.0132 0.2581 0.5621
Schistosoma mansoni tyrosine kinase 0.0037 0.0105 0.0105
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0327 0.7644 0.7644
Onchocerca volvulus 0.0169 0.3548 0.7816
Loa Loa (eye worm) protein kinase domain-containing protein 0.0037 0.0105 0.0124
Echinococcus granulosus cyclin dependent kinase 0.0052 0.0503 0.0503
Echinococcus granulosus retinal guanylyl cyclase 2 0.0037 0.0105 0.0105
Echinococcus granulosus src region 0.0123 0.2347 0.2347
Echinococcus multilocularis SH2 motif 0.0132 0.2581 0.2581
Echinococcus granulosus epidermal growth factor receptor 0.0037 0.0105 0.0105
Loa Loa (eye worm) hypothetical protein 0.0037 0.0105 0.0124
Echinococcus granulosus histone deacetylase 0.0231 0.5162 0.5162
Schistosoma mansoni serine/threonine RGC 0.0037 0.0105 0.0105
Brugia malayi ephrin receptor 1 precursor 0.0037 0.0105 0.0124
Echinococcus granulosus tyrosine protein kinase 0.0037 0.0105 0.0105
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0037 0.0105 0.0105
Brugia malayi Variant SH3 domain containing protein 0.0255 0.5791 0.6879
Brugia malayi C-terminal src kinase protein 1 0.0037 0.0105 0.0124
Echinococcus multilocularis suppressor of cytokine signaling 7 0.0132 0.2581 0.2581
Schistosoma mansoni protein tyrosine kinase 0.0037 0.0105 0.0105
Echinococcus granulosus atrial natriuretic peptide receptor 1 0.0037 0.0105 0.0105
Entamoeba histolytica hypothetical protein 0.0123 0.2347 0.3143
Schistosoma mansoni serine/threonine protein kinase 0.016 0.3314 0.3314
Loa Loa (eye worm) hypothetical protein 0.0037 0.0105 0.0124
Echinococcus multilocularis cyclin dependent kinase 1 0.0052 0.0503 0.0503
Loa Loa (eye worm) hypothetical protein 0.0092 0.1547 0.1838
Echinococcus multilocularis natriuretic peptide receptor 1 0.0037 0.0105 0.0105
Brugia malayi Receptor family ligand binding region containing protein 0.0037 0.0105 0.0124
Brugia malayi SH2 domain containing protein 0.0169 0.3548 0.4215
Schistosoma mansoni tyrosine kinase 0.0037 0.0105 0.0105
Echinococcus granulosus intersectin 2 0.0125 0.2385 0.2385
Schistosoma mansoni eps8-related protein 0.0123 0.2347 0.2347
Brugia malayi Protein kinase domain containing protein 0.0037 0.0105 0.0124
Schistosoma mansoni src-type protein tyrosine kinase-related 0.0037 0.0105 0.0105
Brugia malayi Fes/CIP4 homology domain containing protein 0.0123 0.2347 0.2788
Echinococcus granulosus tyrosine protein kinase Fyn 0.0327 0.7644 0.7644
Schistosoma mansoni tyrosine kinase 0.0037 0.0105 0.0105
Brugia malayi Protein kinase domain containing protein 0.0037 0.0105 0.0124
Brugia malayi Protein kinase domain containing protein 0.0037 0.0105 0.0124
Echinococcus multilocularis histone deacetylase 7 0.0231 0.5162 0.5162
Loa Loa (eye worm) TK/EPH protein kinase 0.0037 0.0105 0.0124
Loa Loa (eye worm) TK/FER protein kinase 0.0169 0.3548 0.4215
Entamoeba histolytica SH2 domain containing protein 0.0132 0.2581 0.3471
Brugia malayi Protein kinase domain containing protein 0.0169 0.3548 0.4215
Echinococcus granulosus tyrosine kinase 0.0037 0.0105 0.0105
Schistosoma mansoni tyrosine kinase 0.0037 0.0105 0.0105
Loa Loa (eye worm) TK/FER protein kinase 0.0037 0.0105 0.0124
Schistosoma mansoni ephrin receptor 0.0037 0.0105 0.0105
Echinococcus granulosus ephrin type A receptor 4 A 0.0037 0.0105 0.0105
Brugia malayi SRC-1 0.0327 0.7644 0.908
Loa Loa (eye worm) hypothetical protein 0.005 0.0435 0.0516
Trichomonas vaginalis histone deacetylase, putative 0.0311 0.7241 1
Entamoeba histolytica protein kinase, putative 0.0123 0.2347 0.3143
Brugia malayi p70 ribosomal S6 kinase beta 0.0048 0.0401 0.0476
Echinococcus granulosus macrophage colony stimulating factor 1 receptor 0.0037 0.0105 0.0105
Loa Loa (eye worm) TKL/MLK/HH498 protein kinase 0.0037 0.0105 0.0124
Onchocerca volvulus 0.0169 0.3548 0.7816
Brugia malayi hypothetical protein 0.0037 0.0105 0.0124
Loa Loa (eye worm) TK/CSK protein kinase 0.0074 0.1067 0.1267
Schistosoma mansoni tyrosine kinase 0.0037 0.0105 0.0105
Echinococcus multilocularis dual specificity testis specific protein kinase 0.004 0.0173 0.0173
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0327 0.7644 0.7644
Schistosoma mansoni dynamin-associated protein 0.0123 0.2347 0.2347
Onchocerca volvulus Histone deacetylase 10 homolog 0.0146 0.2946 0.645
Trypanosoma cruzi histone deacetylase 1, putative 0.0311 0.7241 1
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0052 0.0503 0.0503
Trypanosoma cruzi cdc2-related kinase 3 0.0052 0.0503 0.0559
Loa Loa (eye worm) hypothetical protein 0.0132 0.2581 0.3067
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0292 0.6758 0.6758
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0062 0.0741 0.0891
Trichomonas vaginalis CMGC family protein kinase 0.0062 0.0741 0.0891
Schistosoma mansoni hypothetical protein 0.0123 0.2347 0.2347
Echinococcus multilocularis atrial natriuretic peptide receptor 1 0.0037 0.0105 0.0105
Echinococcus granulosus epidermal growth factor receptor 0.0037 0.0105 0.0105
Echinococcus granulosus mitogen activated protein kinase 3 0.0062 0.0741 0.0741
Schistosoma mansoni tyrosine kinase 0.0292 0.6758 0.6758
Trichomonas vaginalis AGC family protein kinase 0.0051 0.0463 0.0503
Schistosoma mansoni tyrosine-protein kinase fps85d 0.0037 0.0105 0.0105
Brugia malayi Protein kinase domain containing protein 0.0052 0.0503 0.0598
Loa Loa (eye worm) serine/threonine protein kinase 0.0037 0.0105 0.0124
Schistosoma mansoni protein tyrosine phosphatase n11 (shp2) 0.0132 0.2581 0.2581
Brugia malayi Probable tyrosine-protein kinase kin-31 0.0037 0.0105 0.0124
Echinococcus multilocularis transfer RNA-Thr 0.0037 0.0105 0.0105
Entamoeba histolytica hypothetical protein 0.0126 0.241 0.323
Loa Loa (eye worm) TKL/RAF/RAF protein kinase 0.0037 0.0105 0.0124
Brugia malayi Variant SH3 domain containing protein 0.0123 0.2347 0.2788
Echinococcus granulosus suppressor of cytokine signaling 6 0.0132 0.2581 0.2581
Loa Loa (eye worm) TK/FER protein kinase 0.0169 0.3548 0.4215
Echinococcus multilocularis SH2 domain containing adapter protein F 0.0132 0.2581 0.2581
Loa Loa (eye worm) guanylate kinase 0.0123 0.2347 0.2788
Schistosoma mansoni tyrosine kinase 0.0037 0.0105 0.0105
Trypanosoma brucei histone deacetylase, putative 0.0231 0.5162 0.7087
Trichomonas vaginalis p67phox protein, putative 0.0123 0.2347 0.3143
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.0037 0.0105 0.0105
Echinococcus granulosus tyrosine protein kinase Fyn 0.0327 0.7644 0.7644
Loa Loa (eye worm) TK/FER protein kinase 0.0169 0.3548 0.4215
Schistosoma mansoni serine/threonine protein kinase 0.0037 0.0105 0.0105
Loa Loa (eye worm) TKL/MLK/TAK1 protein kinase 0.0037 0.0105 0.0124
Brugia malayi Histone deacetylase family protein 0.0231 0.5162 0.6132
Schistosoma mansoni protein kinase 0.004 0.0173 0.0173
Brugia malayi protein-tyrosine kinase 0.0203 0.4434 0.5268
Loa Loa (eye worm) TK protein kinase 0.0037 0.0105 0.0124
Leishmania major protein kinase, putative 0.004 0.0173 0.0096
Brugia malayi Variant SH3 domain containing protein 0.0139 0.2765 0.3285
Echinococcus multilocularis cyclin dependent kinase 0.0052 0.0503 0.0503
Brugia malayi Guanylate kinase family protein 0.0123 0.2347 0.2788
Echinococcus granulosus activin receptor type 0.004 0.0173 0.0173
Schistosoma mansoni tyrosine kinase 0.0037 0.0105 0.0105
Echinococcus granulosus signal transduction protein lnk realted 0.0132 0.2581 0.2581
Echinococcus multilocularis arf GAP with SH3 domain, ANK repeat and PH 0.0126 0.241 0.241
Trichomonas vaginalis CMGC family protein kinase 0.0062 0.0741 0.0891
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0037 0.0105 0.0105
Giardia lamblia Kinase, CMGC CDK 0.0052 0.0503 0.0559
Plasmodium falciparum protein kinase, putative 0.004 0.0173 0.0096
Trichomonas vaginalis AGC family protein kinase 0.0051 0.0463 0.0503
Brugia malayi Protein kinase domain containing protein 0.0037 0.0105 0.0124
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0062 0.0741 0.0891
Echinococcus granulosus dual specificity mitogen activated protein 0.0089 0.1448 0.1448
Loa Loa (eye worm) TK/RYK protein kinase 0.0037 0.0105 0.0124
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.0037 0.0105 0.0105
Echinococcus multilocularis histone deacetylase 6 0.0231 0.5162 0.5162
Trichomonas vaginalis conserved hypothetical protein 0.0123 0.2347 0.3143
Echinococcus multilocularis activated cdc42 kinase 1 0.0037 0.0105 0.0105
Trypanosoma brucei histone deacetylase 1 0.0311 0.7241 1
Echinococcus granulosus hypothetical protein 0.0132 0.2581 0.2581
Echinococcus multilocularis transfer RNA-Ala 0.0123 0.2347 0.2347
Echinococcus granulosus arf GAP with SH3 domain ANK repeat and PH 0.0126 0.241 0.241
Echinococcus granulosus raf serine:threonine protein kinase 0.0044 0.0288 0.0288
Brugia malayi Variant SH3 domain containing protein 0.0123 0.2347 0.2788
Schistosoma mansoni tyrosine kinase 0.0037 0.0105 0.0105
Echinococcus multilocularis histone deacetylase 3 0.0311 0.7241 0.7241
Schistosoma mansoni GTPase activating protein 0.0132 0.2581 0.2581
Echinococcus granulosus cyclin dependent kinase 1 0.0052 0.0503 0.0503
Loa Loa (eye worm) hypothetical protein 0.0132 0.2581 0.3067
Brugia malayi cytokine inducible SH2-containing protein 5 0.0132 0.2581 0.3067
Entamoeba histolytica cell division protein kinase 2, putative 0.0052 0.0503 0.0559
Schistosoma mansoni tyrosine protein kinase 0.0037 0.0105 0.0105
Leishmania major histone deacetylase, putative 0.0311 0.7241 1
Loa Loa (eye worm) RGC/RGC protein kinase 0.0037 0.0105 0.0124
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0062 0.0741 0.0891
Echinococcus multilocularis fch and double sh3 domains protein 2 0.0123 0.2347 0.2347
Brugia malayi MAP kinase sur-1 0.0062 0.0741 0.088
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.0139 0.2765 0.2765
Echinococcus multilocularis telomerase reverse transcriptase subunit 0.0046 0.0336 0.0336
Onchocerca volvulus 0.0123 0.2347 0.509
Plasmodium vivax histone deacetylase, putative 0.0356 0.8418 1
Schistosoma mansoni formin binding protein and related proteins 0.0123 0.2347 0.2347
Schistosoma mansoni tyrosine kinase 0.0417 1 1
Brugia malayi Protein kinase c protein 2 0.0057 0.0626 0.0744
Trypanosoma cruzi histone deacetylase, putative 0.0146 0.2946 0.3982
Schistosoma mansoni growth factor receptor-bound protein 0.0255 0.5791 0.5791
Plasmodium falciparum histone deacetylase, putative 0.0231 0.5162 0.7087
Brugia malayi hypothetical protein 0.0169 0.3548 0.4215
Schistosoma mansoni protein kinase 0.0037 0.0105 0.0105
Trypanosoma cruzi mitogen-activated protein kinase kinase 5 0.0089 0.1448 0.1883
Loa Loa (eye worm) hypothetical protein 0.0169 0.3548 0.4215
Echinococcus multilocularis slit robo rho gtpase activating protein 1 0.0123 0.2347 0.2347
Echinococcus granulosus tyrosine kinase 0.0203 0.4434 0.4434
Schistosoma mansoni serine/threonine protein kinase 0.0079 0.1198 0.1198
Loa Loa (eye worm) hypothetical protein 0.0123 0.2347 0.2788
Loa Loa (eye worm) TK/FER protein kinase 0.0037 0.0105 0.0124
Trypanosoma cruzi cdc2-related kinase 1 0.0052 0.0503 0.0559
Loa Loa (eye worm) histone deacetylase 1 0.0311 0.7241 0.8602
Echinococcus granulosus integrin linked protein kinase 0.0037 0.0105 0.0105
Schistosoma mansoni growth factor receptor-bound protein 0.0255 0.5791 0.5791
Loa Loa (eye worm) hypothetical protein 0.0046 0.0336 0.0399
Echinococcus granulosus tyrosine protein kinase Lyn 0.0329 0.7712 0.7712
Loa Loa (eye worm) TKL/STKR/TYPE1 protein kinase 0.0037 0.0105 0.0124
Brugia malayi Immunoglobulin I-set domain containing protein 0.0037 0.0105 0.0124
Echinococcus multilocularis integrin linked protein kinase 0.0037 0.0105 0.0105
Brugia malayi histone deacetylase 11 0.0356 0.8418 1
Schistosoma mansoni tyrosine kinase 0.0169 0.3548 0.3548
Echinococcus multilocularis tyrosine protein kinase csk 0.0074 0.1067 0.1067
Echinococcus granulosus Protein kinase C brain isozyme 0.0079 0.1198 0.1198
Loa Loa (eye worm) hypothetical protein 0.0132 0.2581 0.3067
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0037 0.0105 0.0105
Echinococcus multilocularis histone deacetylase 0.0231 0.5162 0.5162
Schistosoma mansoni SH2A 0.0132 0.2581 0.2581
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0166 0.3467 0.3467
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0327 0.7644 0.7644
Loa Loa (eye worm) hypothetical protein 0.0123 0.2347 0.2788
Echinococcus granulosus tensin C1 domain containing phosphatase 0.0132 0.2581 0.2581
Schistosoma mansoni protein kinase 0.004 0.0173 0.0173
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0123 0.2347 0.2788
Toxoplasma gondii histone deacetylase HDAC1 0.0231 0.5162 0.6083
Schistosoma mansoni run and tbc1 domain containing 0.0123 0.2347 0.2347
Schistosoma mansoni tyrosine protein kinase fes (fps) (ptk group IV) 0.0037 0.0105 0.0105
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0037 0.0105 0.0105
Schistosoma mansoni histone deacetylase 0.0311 0.7241 0.7241
Schistosoma mansoni tyrosine kinase 0.0329 0.772 0.772
Plasmodium vivax histone deacetylase 2, putative 0.0231 0.5162 0.6083
Echinococcus granulosus nostrin 0.0123 0.2347 0.2347
Echinococcus multilocularis mitogen activated protein kinase 3 0.0062 0.0741 0.0741
Brugia malayi Protein kinase domain containing protein 0.0037 0.0105 0.0124
Trichomonas vaginalis CMGC family protein kinase 0.0062 0.0741 0.0891
Brugia malayi histone deacetylase 3 (HD3) 0.0311 0.7241 0.8602
Loa Loa (eye worm) hypothetical protein 0.0037 0.0105 0.0124
Echinococcus multilocularis breast cancer anti estrogen resistance protein 0.0123 0.2347 0.2347
Echinococcus granulosus receptor type guanylyl cyclase 0.0037 0.0105 0.0105
Brugia malayi Variant SH3 domain containing protein 0.0123 0.2347 0.2788
Trichomonas vaginalis conserved hypothetical protein 0.0123 0.2347 0.3143
Schistosoma mansoni protein kinase 0.0037 0.0105 0.0105
Brugia malayi Protein kinase domain containing protein 0.0037 0.0105 0.0124
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.004 0.0173 0.0096
Echinococcus multilocularis ephrin type A receptor 4 A 0.0037 0.0105 0.0105
Brugia malayi SH3 domain containing protein 0.0123 0.2347 0.2788
Brugia malayi Protein kinase domain containing protein 0.0037 0.0105 0.0124
Schistosoma mansoni dreadlocks/dock 0.0123 0.2347 0.2347
Trypanosoma brucei STE/STE11 serine/threonine-protein kinase, putative 0.004 0.0173 0.0096
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0062 0.0741 0.0891
Onchocerca volvulus 0.0123 0.2347 0.509
Brugia malayi Guanylyl cyclase protein 23 0.0037 0.0105 0.0124
Loa Loa (eye worm) TK protein kinase 0.0037 0.0105 0.0124
Echinococcus multilocularis tyrosine protein kinase csk 0.0074 0.1067 0.1067
Giardia lamblia Kinase, CMGC CDK 0.0052 0.0503 0.0559
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0136 0.2682 0.3186
Echinococcus granulosus 3'partial|retinal guanylyl cyclase 2 0.0037 0.0105 0.0105
Schistosoma mansoni signal transducing adapter molecule (stam) 0.0123 0.2347 0.2347
Loa Loa (eye worm) histone deacetylase 0.0231 0.5162 0.6132
Echinococcus granulosus SH2 motif 0.0132 0.2581 0.2581
Onchocerca volvulus Suppressor of cytokine signaling 7 homolog 0.0132 0.2581 0.5621
Trypanosoma brucei cdc2-related kinase 1 0.0052 0.0503 0.0559
Schistosoma mansoni tyrosine kinase 0.0037 0.0105 0.0105
Trypanosoma cruzi histone deacetylase, putative 0.0231 0.5162 0.7087
Brugia malayi tRNA modification GTPase TrmE family protein 0.0132 0.2581 0.3067
Brugia malayi Tyrosine-protein kinase abl-1 0.0292 0.6758 0.8028
Brugia malayi Protein kinase domain containing protein 0.0037 0.0105 0.0124
Echinococcus multilocularis tyrosine protein kinase Fes:Fps 0.0037 0.0105 0.0105
Giardia lamblia Histone deacetylase 0.0311 0.7241 1
Echinococcus multilocularis tyrosine protein kinase csk 0.0074 0.1067 0.1067
Echinococcus multilocularis tyrosine protein kinase Blk 0.0203 0.4434 0.4434
Echinococcus granulosus hematopoietic lineage cell specific protein 0.0123 0.2347 0.2347
Schistosoma mansoni hypothetical protein 0.0132 0.2581 0.2581
Echinococcus granulosus SH2 motif 0.0132 0.2581 0.2581
Schistosoma mansoni development and differentiation-enhancing factor ddef 0.0126 0.241 0.241
Trichomonas vaginalis AGC family protein kinase 0.0051 0.0463 0.0503
Schistosoma mansoni tyrosine kinase 0.0037 0.0105 0.0105
Schistosoma mansoni protein kinase 0.0037 0.0105 0.0105
Echinococcus granulosus slit robo rho gtpase activating protein 1 0.0123 0.2347 0.2347
Echinococcus multilocularis endophilin A3 0.0123 0.2347 0.2347
Loa Loa (eye worm) AGC/AKT protein kinase 0.0051 0.0463 0.055
Schistosoma mansoni tyrosine kinase 0.0037 0.0105 0.0105
Echinococcus granulosus natriuretic peptide receptor 1 0.0037 0.0105 0.0105
Trichomonas vaginalis histone deacetylase, putative 0.0311 0.7241 1
Brugia malayi SH2 domain containing protein 0.0132 0.2581 0.3067
Schistosoma mansoni signal transduction protein lnk-related 0.0132 0.2581 0.2581
Echinococcus granulosus kinase suppressor of Ras 1 0.0037 0.0105 0.0105
Schistosoma mansoni protein kinase 0.0037 0.0105 0.0105
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0132 0.2581 0.2581
Entamoeba histolytica protein kinase, putative 0.0135 0.265 0.3567
Schistosoma mansoni tyrosine protein kinase fes (fps) (ptk group IV) 0.0037 0.0105 0.0105
Echinococcus granulosus epidermal growth factor receptor kinase 0.0123 0.2347 0.2347
Schistosoma mansoni sorting nexin 0.0123 0.2347 0.2347
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0062 0.0741 0.0765
Brugia malayi Protein kinase domain containing protein 0.0037 0.0105 0.0124
Echinococcus multilocularis tyrosine protein kinase pr2 0.0037 0.0105 0.0105
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0327 0.7644 0.7644
Brugia malayi integrin-linked kinase 0.0037 0.0105 0.0124
Echinococcus multilocularis protein kinase 0.0037 0.0105 0.0105
Loa Loa (eye worm) hypothetical protein 0.0123 0.2347 0.2788
Loa Loa (eye worm) TK protein kinase 0.0071 0.099 0.1177
Loa Loa (eye worm) hypothetical protein 0.0132 0.2581 0.3067
Echinococcus multilocularis phosphatidylinositol 3 kinase regulatory subunit 0.0132 0.2581 0.2581
Loa Loa (eye worm) TK/ALK protein kinase 0.0037 0.0105 0.0124
Schistosoma mansoni serine/threonine protein kinase 0.0052 0.0503 0.0503
Trichomonas vaginalis AGC family protein kinase 0.0051 0.0463 0.0503
Loa Loa (eye worm) SH2 domain-containing protein 0.0169 0.3544 0.421
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0327 0.7644 0.7644
Echinococcus multilocularis growth factor receptor bound protein 2 0.0255 0.5791 0.5791
Onchocerca volvulus Putative cortactin 0.0123 0.2347 0.509
Leishmania major histone deacetylase, putative 0.0231 0.5162 0.7087
Schistosoma mansoni histone deacetylase 0.0311 0.7241 0.7241
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0037 0.0105 0.0105
Loa Loa (eye worm) TK/FAK protein kinase 0.0037 0.0105 0.0124
Onchocerca volvulus 0.0123 0.2347 0.509
Brugia malayi Peripheral plasma membrane protein CASK 0.0123 0.2347 0.2788
Echinococcus granulosus c src tyrosine kinase 0.0329 0.772 0.772
Echinococcus multilocularis suppressor of cytokine signaling 6 0.0132 0.2581 0.2581
Brugia malayi Myosin tail family protein 0.0123 0.2347 0.2788
Loa Loa (eye worm) TK/FER protein kinase 0.0037 0.0105 0.0124
Echinococcus multilocularis NCK adaptor protein 0.0255 0.5791 0.5791
Schistosoma mansoni tyrosine kinase 0.0037 0.0105 0.0105
Echinococcus granulosus tyrosine protein kinase Blk 0.0203 0.4434 0.4434
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0037 0.0105 0.0105
Trypanosoma brucei protein kinase, putative 0.0062 0.0741 0.0891
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0132 0.2581 0.2581
Brugia malayi proto-oncogene tyrosine-protein kinase FER 0.0037 0.0105 0.0124
Brugia malayi Furin-like cysteine rich region family protein 0.0037 0.0105 0.0124
Echinococcus multilocularis signal transduction protein lnk realted 0.0132 0.2581 0.2581
Echinococcus granulosus expressed protein 0.0123 0.2347 0.2347
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0062 0.0741 0.088
Schistosoma mansoni tyrosine kinase 0.0037 0.0105 0.0105
Loa Loa (eye worm) histone deacetylase 11 0.0356 0.8418 1
Trypanosoma brucei cdc2-related kinase 3 0.0052 0.0503 0.0559
Echinococcus multilocularis cyclin dependent kinase 5 0.0052 0.0503 0.0503
Loa Loa (eye worm) SH2 domain-containing protein 0.0132 0.2581 0.3067
Echinococcus multilocularis epidermal growth factor receptor 0.0037 0.0105 0.0105
Echinococcus granulosus insulin receptor 0.0037 0.0105 0.0105
Onchocerca volvulus 0.0132 0.2581 0.5621
Trichomonas vaginalis histone deacetylase, putative 0.0311 0.7241 1
Brugia malayi SH2 domain containing protein 0.0132 0.2581 0.3067
Trypanosoma cruzi histone deacetylase 1, putative 0.0311 0.7241 1
Echinococcus multilocularis Spectrin alpha actinin 0.0123 0.2347 0.2347
Loa Loa (eye worm) hypothetical protein 0.0037 0.0105 0.0124
Echinococcus granulosus expressed conserved protein 0.0132 0.2581 0.2581
Echinococcus granulosus histone deacetylase 8 0.0146 0.2946 0.2946
Schistosoma mansoni tyrosine kinase 0.0037 0.0105 0.0105
Trichomonas vaginalis histone deacetylase, putative 0.0311 0.7241 1
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.004 0.0173 0.0096
Loa Loa (eye worm) TK/FER protein kinase 0.0169 0.3548 0.4215
Brugia malayi Protein kinase domain containing protein 0.0037 0.0105 0.0124
Loa Loa (eye worm) hypothetical protein 0.0037 0.0105 0.0124
Brugia malayi Probable tyrosine-protein kinase kin-31 0.0037 0.0105 0.0124
Brugia malayi Histone deacetylase family protein 0.0231 0.5162 0.6132
Entamoeba histolytica hypothetical protein 0.0123 0.2347 0.3143
Loa Loa (eye worm) TK/FER protein kinase 0.0169 0.3548 0.4215
Brugia malayi SH2 domain containing protein 0.0132 0.2581 0.3067
Schistosoma mansoni hypothetical protein 0.0037 0.0105 0.0105
Brugia malayi Dual specificity mitogen-activated protein kinase kinase mek-2 0.0089 0.1448 0.172
Loa Loa (eye worm) hypothetical protein 0.0085 0.1353 0.1607
Giardia lamblia Kinase, STE STE20 0.0089 0.1448 0.1883
Echinococcus multilocularis expressed protein 0.0123 0.2347 0.2347
Onchocerca volvulus 0.0206 0.4511 1
Schistosoma mansoni histone deacetylase 4 5 0.0231 0.5162 0.5162
Toxoplasma gondii histone deacetylase HDAC2 0.0311 0.7241 0.8584
Brugia malayi Protein kinase domain containing protein 0.0037 0.0105 0.0124
Loa Loa (eye worm) hypothetical protein 0.0123 0.2347 0.2788
Trypanosoma cruzi histone deacetylase, putative 0.0146 0.2946 0.3982
Echinococcus granulosus histone deacetylase 6 0.0231 0.5162 0.5162
Schistosoma mansoni cell polarity protein 0.0123 0.2347 0.2347
Loa Loa (eye worm) hypothetical protein 0.0132 0.2581 0.3067
Echinococcus granulosus tyrosine protein kinase HCK 0.0071 0.099 0.099
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0255 0.5791 0.6879
Echinococcus multilocularis receptor type guanylyl cyclase 0.0037 0.0105 0.0105
Echinococcus granulosus histone deacetylase 6 0.0239 0.5356 0.5356
Loa Loa (eye worm) TK/FER protein kinase 0.0169 0.3548 0.4215
Echinococcus granulosus tyrosine protein kinase Src42A 0.0166 0.3467 0.3467
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0037 0.0105 0.0105
Echinococcus multilocularis 0.0132 0.2581 0.2581
Schistosoma mansoni nck2/grb4 0.0255 0.5791 0.5791
Trypanosoma cruzi cdc2-related kinase 1 0.0052 0.0503 0.0559
Loa Loa (eye worm) hypothetical protein 0.0123 0.2347 0.2788
Giardia lamblia Kinase, CMGC MAPK 0.0062 0.0741 0.0891
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0062 0.0741 0.0891
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0292 0.6758 0.6758
Onchocerca volvulus 0.0169 0.3548 0.7816
Plasmodium vivax histone deacetylase, putative 0.0231 0.5162 0.6083
Schistosoma mansoni tyrosine kinase 0.0037 0.0105 0.0105
Schistosoma mansoni C-fyn 0.0123 0.2347 0.2347
Loa Loa (eye worm) hypothetical protein 0.0037 0.0105 0.0124
Echinococcus multilocularis macrophage colony stimulating factor 1 receptor 0.0037 0.0105 0.0105
Brugia malayi Spectrin alpha chain 0.0123 0.2347 0.2788
Brugia malayi Protein kinase domain containing protein 0.0037 0.0105 0.0124
Loa Loa (eye worm) hypothetical protein 0.0037 0.0105 0.0124
Schistosoma mansoni protein kinase 0.0037 0.0105 0.0105
Onchocerca volvulus 0.0169 0.3548 0.7816
Echinococcus granulosus protein kinase 0.0037 0.0105 0.0105
Brugia malayi Variant SH3 domain containing protein 0.0123 0.2347 0.2788
Brugia malayi Protein kinase domain containing protein 0.0169 0.3548 0.4215
Brugia malayi SH2 domain containing protein 0.0206 0.4511 0.5358
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0052 0.0503 0.048
Loa Loa (eye worm) protein kinase C and casein kinase substrate in neurons protein 2 0.0123 0.2347 0.2788
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0037 0.0105 0.0105
Trichomonas vaginalis STE family protein kinase 0.0089 0.1448 0.1883
Echinococcus multilocularis raf serine:threonine protein kinase 0.0044 0.0288 0.0288
Brugia malayi protein-tyrosine kinase 0.0123 0.2347 0.2788
Brugia malayi Variant SH3 domain containing protein 0.0123 0.2347 0.2788
Brugia malayi Variant SH3 domain containing protein 0.0136 0.2682 0.3186
Echinococcus multilocularis kinase suppressor of Ras 1 0.0037 0.0105 0.0105
Brugia malayi Raf kinase 0.0037 0.0105 0.0124
Echinococcus granulosus retinal guanylyl cyclase 2 0.0037 0.0105 0.0105
Echinococcus multilocularis tyrosine kinase 0.0037 0.0105 0.0105
Brugia malayi Protein kinase domain containing protein 0.0037 0.0105 0.0124
Trypanosoma cruzi hypothetical protein, conserved 0.0123 0.2347 0.3143
Loa Loa (eye worm) hypothetical protein 0.0037 0.0105 0.0124
Echinococcus multilocularis cyclin dependent kinase 1 0.0052 0.0503 0.0503
Echinococcus granulosus breast cancer anti estrogen resistance protein 0.0123 0.2347 0.2347
Loa Loa (eye worm) TK protein kinase 0.0037 0.0105 0.0124
Trypanosoma brucei histone deacetylase 2 0.0146 0.2946 0.3982
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0203 0.4434 0.4434
Schistosoma mansoni tyrosine kinase 0.0037 0.0105 0.0105
Echinococcus multilocularis epidermal growth factor receptor kinase 0.0123 0.2347 0.2347
Echinococcus multilocularis histone deacetylase 1 0.0311 0.7241 0.7241
Echinococcus granulosus tyrosine kinase 0.0169 0.3548 0.3548
Echinococcus multilocularis FL cytokine receptor 0.0037 0.0105 0.0105
Trichomonas vaginalis AGC family protein kinase 0.0051 0.0463 0.0503
Schistosoma mansoni tyrosine kinase 0.0285 0.6556 0.6556
Schistosoma mansoni sh3-containing grb2-like protein 1 (endophilin II) 0.0123 0.2347 0.2347
Echinococcus multilocularis RNA directed DNA polymerase 0.0046 0.0336 0.0336
Loa Loa (eye worm) STAT protein 0.0132 0.2581 0.3067
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0079 0.1198 0.1198
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0139 0.2765 0.2765
Loa Loa (eye worm) hypothetical protein 0.0132 0.2581 0.3067
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0327 0.7644 0.7644
Echinococcus granulosus phosphatidylinositol 3 kinase regulatory subunit 0.0132 0.2581 0.2581
Schistosoma mansoni suppressor of cytokine signaling 0.0132 0.2581 0.2581
Schistosoma mansoni protein kinase 0.0037 0.0105 0.0105
Loa Loa (eye worm) hypothetical protein 0.0037 0.0105 0.0124
Schistosoma mansoni tensin-related 0.0132 0.2581 0.2581
Loa Loa (eye worm) TK protein kinase 0.0037 0.0105 0.0124
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0169 0.3548 0.3548
Brugia malayi RhoGAP domain containing protein 0.0139 0.2765 0.3285
Trypanosoma brucei histone deacetylase 3 0.0231 0.5162 0.7087
Brugia malayi Sex muscle abnormal protein 5 0.0255 0.5791 0.6879
Echinococcus granulosus tyrosine protein kinase pr2 0.0037 0.0105 0.0105
Trichomonas vaginalis CMGC family protein kinase 0.0062 0.0741 0.0891
Echinococcus multilocularis insulin receptor 0.0037 0.0105 0.0105
Loa Loa (eye worm) hypothetical protein 0.0123 0.2347 0.2788
Echinococcus multilocularis N chimaerin 0.0139 0.2765 0.2765
Schistosoma mansoni protein kinase 0.004 0.0173 0.0173
Echinococcus granulosus tyrosine protein kinase Fes:Fps 0.0037 0.0105 0.0105
Schistosoma mansoni sorbin 0.0123 0.2347 0.2347
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0052 0.0503 0.0559
Loa Loa (eye worm) RGC/RGC protein kinase 0.0037 0.0105 0.0124
Echinococcus granulosus NCK adaptor protein 0.0255 0.5791 0.5791
Schistosoma mansoni protein kinase 0.0037 0.0105 0.0105
Schistosoma mansoni tyrosine kinase 0.0327 0.7644 0.7644
Echinococcus granulosus histone deacetylase 6 0.0231 0.5162 0.5162

Activities

Activity type Activity value Assay description Source Reference
GI50 (functional) = 1.23 uM Antiproliferative activity against human HeLa cells assessed as growth inhibition after 72 hrs by CCK-8 assay ChEMBL. 25218912
IC50 (binding) = 0.029 uM Inhibition of human recombinant HDAC10 after 60 mins by fluorimetric assay ChEMBL. 25218912
IC50 (binding) = 0.03 uM Inhibition of human recombinant HDAC3 after 60 mins by fluorimetric assay ChEMBL. 25218912
IC50 (binding) = 0.033 uM Inhibition of human recombinant HDAC1 after 60 mins by fluorimetric assay ChEMBL. 25218912
IC50 (binding) = 0.034 uM Inhibition of human recombinant HDAC6 after 60 mins by fluorimetric assay ChEMBL. 25218912
IC50 (binding) = 0.226 uM Inhibition of human recombinant HDAC2 after 60 mins by fluorimetric assay ChEMBL. 25218912
IC50 (binding) = 1.725 uM Inhibition of human recombinant HDAC11 after 60 mins by fluorimetric assay ChEMBL. 25218912
IC50 (binding) = 5.238 uM Inhibition of human recombinant HDAC8 after 60 mins by fluorimetric assay ChEMBL. 25218912
IC50 (binding) = 47.2 uM Inhibition of human recombinant HDAC9 after 60 mins by fluorimetric assay ChEMBL. 25218912
IC50 (binding) = 83.1 uM Inhibition of human recombinant HDAC4 after 60 mins by fluorimetric assay ChEMBL. 25218912
Inhibition (binding) Inhibition of HDAC in human HCT116 cells assessed as increase in acetylated alpha-tubulin level after 24 hrs by Western blot analysis ChEMBL. 25218912
Inhibition (binding) Inhibition of HDAC in human HCT116 cells assessed as increase in acetylated H3 level after 24 hrs by Western blot analysis ChEMBL. 25218912
Inhibition (binding) Inhibition of human recombinant HDAC6 up to 10 uM after 60 mins by fluorimetric assay ChEMBL. 25218912
Inhibition (binding) Inhibition of human recombinant HDAC10 up to 10 uM after 60 mins by fluorimetric assay ChEMBL. 25218912

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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