Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium vivax | beta-ketoacyl-acyl carrier protein synthase III precursor, putative | 0.3327 | 1 | 1 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0023 | 0.0019 | 0.0062 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0019 | 0.0062 |
Brugia malayi | mbt repeat family protein | 0.0055 | 0.0117 | 0.0381 |
Loa Loa (eye worm) | mbt repeat family protein | 0.0055 | 0.0117 | 0.0381 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0023 | 0.0019 | 0.0062 |
Toxoplasma gondii | sphingolipid delta 4 desaturase/c-4 hydroxylase protein des2 family protein | 0.0272 | 0.0771 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0044 | 0.0143 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0023 | 0.0019 | 0.0062 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0031 | 0.0044 | 0.0143 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0023 | 0.0019 | 0.0148 |
Mycobacterium ulcerans | transmembrane alkane 1-monooxygenase AlkB | 0.0272 | 0.0771 | 0.0771 |
Brugia malayi | intermediate filament protein | 0.0031 | 0.0044 | 0.0143 |
Mycobacterium ulcerans | linoleoyl-CoA desaturase, DesA3_2 | 0.0272 | 0.0771 | 0.0771 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0023 | 0.0019 | 0.0186 |
Loa Loa (eye worm) | hypothetical protein | 0.0055 | 0.0117 | 0.0381 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0053 | 0.011 | 0.1093 |
Entamoeba histolytica | fatty acid elongase, putative | 0.0432 | 0.1255 | 0.5 |
Echinococcus granulosus | SAM and MBT domain containing protein | 0.0055 | 0.0117 | 0.146 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0023 | 0.0019 | 0.0062 |
Echinococcus granulosus | FTZ F1 alpha | 0.0023 | 0.0019 | 0.0186 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.0124 | 0.0406 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0023 | 0.0019 | 0.0148 |
Trypanosoma cruzi | fatty acid desaturase, putative | 0.0272 | 0.0771 | 0.1987 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0018 | 0.0005 | 0.0015 |
Trypanosoma cruzi | fatty acid desaturase, putative | 0.103 | 0.306 | 0.7883 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0031 | 0.0044 | 0.0143 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0023 | 0.0019 | 0.0053 |
Schistosoma mansoni | coup transcription factor | 0.0023 | 0.0019 | 0.0148 |
Echinococcus granulosus | Sphingolipid delta4 desaturase DES1 | 0.0272 | 0.0771 | 1 |
Brugia malayi | Delta5 fatty acid desaturase | 0.0272 | 0.0771 | 0.252 |
Mycobacterium ulcerans | hypothetical protein | 0.0272 | 0.0771 | 0.0771 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.014 | 0.0457 |
Echinococcus granulosus | lamin dm0 | 0.0031 | 0.0044 | 0.0512 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0023 | 0.0019 | 0.0186 |
Mycobacterium ulcerans | linoleoyl-CoA desaturase, DesA3 | 0.0272 | 0.0771 | 0.0771 |
Onchocerca volvulus | 0.0055 | 0.0117 | 0.0253 | |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0023 | 0.0019 | 0.0062 |
Mycobacterium ulcerans | beta-ketoacyl synthase-like protein | 0.3327 | 1 | 1 |
Trypanosoma cruzi | sphingolipid delta 4 desaturase, putative | 0.0272 | 0.0771 | 0.1987 |
Mycobacterium ulcerans | hypothetical protein | 0.0272 | 0.0771 | 0.0771 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.004 | 0.0069 | 0.0225 |
Echinococcus multilocularis | Peptidase M, neutral zinc metallopeptidases, zinc binding site | 0.0272 | 0.0771 | 0.2859 |
Mycobacterium ulcerans | 3-oxoacyl-ACP synthase | 0.3327 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0019 | 0.0062 |
Echinococcus granulosus | suppression of tumorigenicity 18 protein | 0.0063 | 0.014 | 0.1762 |
Echinococcus multilocularis | suppression of tumorigenicity 18 protein | 0.0063 | 0.014 | 0.0504 |
Trypanosoma cruzi | fatty acid desaturase, putative | 0.1302 | 0.3882 | 1 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0023 | 0.0019 | 0.0148 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0023 | 0.0019 | 0.0062 |
Brugia malayi | ecdysteroid receptor | 0.0023 | 0.0019 | 0.0062 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0005 | 0.0015 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0023 | 0.0019 | 0.0062 |
Loa Loa (eye worm) | fatty acid desaturase | 0.0272 | 0.0771 | 0.252 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0023 | 0.0019 | 0.0148 |
Echinococcus multilocularis | histone acetyltransferase MYST2 | 0.0063 | 0.014 | 0.0504 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0023 | 0.0019 | 0.0062 |
Brugia malayi | Fatty acid desaturase family protein | 0.0272 | 0.0771 | 0.252 |
Loa Loa (eye worm) | MBCTL1 | 0.0063 | 0.014 | 0.0457 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0023 | 0.0019 | 0.0186 |
Entamoeba histolytica | fatty acid elongase, putative | 0.0432 | 0.1255 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0019 | 0.0062 |
Schistosoma mansoni | nuclear hormone receptor | 0.0023 | 0.0019 | 0.0148 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0053 | 0.011 | 0.0392 |
Brugia malayi | nuclear receptor NHR-88 | 0.0023 | 0.0019 | 0.0062 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0018 | 0.0005 | 0.0015 |
Trypanosoma brucei | fatty acid desaturase, putative | 0.1302 | 0.3882 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0272 | 0.0771 | 0.252 |
Brugia malayi | nuclear hormone receptor | 0.0023 | 0.0019 | 0.0062 |
Trypanosoma brucei | delta-6 fatty acid desaturase, putative | 0.0272 | 0.0771 | 0.1987 |
Trypanosoma cruzi | delta-4 fatty acid desaturase, putative | 0.0272 | 0.0771 | 0.1987 |
Trypanosoma brucei | cytochrome b5-dependent oleate desaturase | 0.0272 | 0.0771 | 0.1987 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0023 | 0.0019 | 0.0186 |
Echinococcus multilocularis | endonuclease exonuclease phosphatase | 0.0218 | 0.0608 | 0.2252 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0017 | 0.0000013781 | 0.0000045041 |
Echinococcus multilocularis | Peptidase M, neutral zinc metallopeptidases, zinc binding site | 0.0272 | 0.0771 | 0.2859 |
Onchocerca volvulus | 0.0272 | 0.0771 | 0.1948 | |
Loa Loa (eye worm) | fatty acid desaturase | 0.0272 | 0.0771 | 0.252 |
Schistosoma mansoni | sex comb on midleg homolog | 0.0055 | 0.0117 | 0.1164 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0019 | 0.0062 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0023 | 0.0019 | 0.0062 |
Onchocerca volvulus | Polycomb protein Sfmbt homolog | 0.0055 | 0.0117 | 0.0253 |
Echinococcus granulosus | polycomb protein SCMH1 | 0.0055 | 0.0117 | 0.146 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0023 | 0.0019 | 0.0053 |
Trypanosoma brucei | sphingolipid delta 4 desaturase, putative | 0.0272 | 0.0771 | 0.1987 |
Mycobacterium ulcerans | linoleoyl-CoA desaturase, DesA3 | 0.0272 | 0.0771 | 0.0771 |
Schistosoma mansoni | hypothetical protein | 0.004 | 0.0069 | 0.0668 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0023 | 0.0019 | 0.0053 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0053 | 0.011 | 0.1093 |
Schistosoma mansoni | hypothetical protein | 0.0337 | 0.0966 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0019 | 0.0062 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0053 | 0.011 | 0.1093 |
Leishmania major | fatty acid desaturase, putative,sphingolipid delta 4 desaturase, putative | 0.0272 | 0.0771 | 0.1987 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0023 | 0.0019 | 0.0148 |
Leishmania major | fatty acid desaturase, putative | 0.0272 | 0.0771 | 0.1987 |
Leishmania major | fatty acid desaturase, putative,sphingolipid delta 4 desaturase, putative | 0.0272 | 0.0771 | 0.1987 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0042 | 0.0138 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0023 | 0.0019 | 0.0053 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0017 | 0.0000013781 | 0.0000045041 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0023 | 0.0019 | 0.0062 |
Trypanosoma cruzi | fatty acid desaturase, putative | 0.103 | 0.306 | 0.7883 |
Schistosoma mansoni | lamin | 0.0031 | 0.0044 | 0.0408 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0053 | 0.011 | 0.1371 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0019 | 0.0062 |
Plasmodium falciparum | beta-ketoacyl-ACP synthase III | 0.3327 | 1 | 1 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0023 | 0.0019 | 0.0053 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0023 | 0.0019 | 0.0062 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0053 | 0.011 | 0.0392 |
Leishmania major | delta-5 fatty acid desaturase | 0.0272 | 0.0771 | 0.1987 |
Mycobacterium ulcerans | 3-oxoacyl-ACP synthase | 0.3327 | 1 | 1 |
Schistosoma mansoni | lamin | 0.0031 | 0.0044 | 0.0408 |
Loa Loa (eye worm) | acyl-CoA desaturase | 0.103 | 0.306 | 1 |
Onchocerca volvulus | 0.1302 | 0.3882 | 1 | |
Echinococcus multilocularis | polycomb protein SCMH1 | 0.0055 | 0.0117 | 0.0417 |
Echinococcus granulosus | Fatty acid desaturase type 1 | 0.0272 | 0.0771 | 1 |
Brugia malayi | mbt repeat family protein | 0.0055 | 0.0117 | 0.0381 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0023 | 0.0019 | 0.0062 |
Leishmania major | delta-12 fatty acid desaturase | 0.0272 | 0.0771 | 0.1987 |
Brugia malayi | steroid hormone receptor | 0.0023 | 0.0019 | 0.0062 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0018 | 0.0005 | 0.0015 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0023 | 0.0019 | 0.0062 |
Trypanosoma cruzi | delta-4 fatty acid desaturase, putative | 0.0272 | 0.0771 | 0.1987 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0023 | 0.0019 | 0.0053 |
Brugia malayi | Cytochrome P450 family protein | 0.0017 | 0.0000013781 | 0.0000045041 |
Entamoeba histolytica | fatty acid elongase, putative | 0.0432 | 0.1255 | 0.5 |
Onchocerca volvulus | 0.0031 | 0.0044 | 0.0065 | |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0023 | 0.0019 | 0.0186 |
Trypanosoma cruzi | cytochrome b5-dependent oleate desaturase | 0.0272 | 0.0771 | 0.1987 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0023 | 0.0019 | 0.0053 |
Echinococcus multilocularis | lamin | 0.0031 | 0.0044 | 0.0146 |
Leishmania major | stearic acid desaturase, putative | 0.1302 | 0.3882 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0019 | 0.0062 |
Schistosoma mansoni | fatty acid desaturase | 0.0272 | 0.0771 | 0.7974 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0023 | 0.0019 | 0.0062 |
Leishmania major | delta-4 fatty acid desaturase | 0.0272 | 0.0771 | 0.1987 |
Trypanosoma brucei | delta-4 fatty acid desaturase | 0.0272 | 0.0771 | 0.1987 |
Schistosoma mansoni | sex comb on midleg homolog | 0.0055 | 0.0117 | 0.1164 |
Brugia malayi | Cytochrome P450 family protein | 0.0017 | 0.0000013781 | 0.0000045041 |
Echinococcus multilocularis | musashi | 0.0031 | 0.0044 | 0.0146 |
Mycobacterium tuberculosis | 3-oxoacyl-[acyl-carrier-protein] synthase III FabH (beta-ketoacyl-ACP synthase III) (KAS III) | 0.3327 | 1 | 1 |
Leishmania major | delta-6 fatty acid desaturase | 0.0272 | 0.0771 | 0.1987 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0023 | 0.0019 | 0.0062 |
Entamoeba histolytica | fatty acid elongase, putative | 0.0432 | 0.1255 | 0.5 |
Schistosoma mansoni | scm-relatedprotein containing 4 mbt domains (sfmbt) | 0.0055 | 0.0117 | 0.1164 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0023 | 0.0019 | 0.0053 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0069 | 0.0225 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0023 | 0.0019 | 0.0062 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0023 | 0.0019 | 0.0062 |
Entamoeba histolytica | fatty acid elongase, putative | 0.0432 | 0.1255 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0023 | 0.0019 | 0.0062 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0019 | 0.0062 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0053 | 0.011 | 0.1371 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0023 | 0.0019 | 0.0148 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0023 | 0.0019 | 0.0062 |
Echinococcus multilocularis | atpase aaa+ type core atpase aaa type core | 0.0906 | 0.2686 | 1 |
Trypanosoma cruzi | fatty acid desaturase, putative | 0.0272 | 0.0771 | 0.1987 |
Schistosoma mansoni | myelin transcription factor 1 myt1 | 0.0063 | 0.014 | 0.1405 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0023 | 0.0019 | 0.0062 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0023 | 0.0019 | 0.0062 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0017 | 0.0000013781 | 0.0000045041 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0058 | 0.0124 | 0.0406 |
Onchocerca volvulus | 0.0031 | 0.0044 | 0.0065 | |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0058 | 0.0124 | 0.0406 |
Schistosoma mansoni | intermediate filament proteins | 0.0031 | 0.0044 | 0.0408 |
Mycobacterium ulcerans | electron transfer protein FdxB | 0.0272 | 0.0771 | 0.0771 |
Echinococcus granulosus | histone acetyltransferase MYST2 | 0.0063 | 0.014 | 0.1762 |
Loa Loa (eye worm) | intermediate filament protein | 0.0031 | 0.0044 | 0.0143 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0053 | 0.011 | 0.0359 |
Leishmania major | fatty acid desaturase, putative,sphingolipid delta 4 desaturase, putative | 0.0272 | 0.0771 | 0.1987 |
Echinococcus granulosus | endonuclease exonuclease phosphatase | 0.0218 | 0.0608 | 0.7875 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0023 | 0.0019 | 0.0062 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0023 | 0.0019 | 0.0053 |
Schistosoma mansoni | thyroid hormone receptor | 0.0023 | 0.0019 | 0.0148 |
Leishmania major | fatty-acid desaturase, putative | 0.1302 | 0.3882 | 1 |
Brugia malayi | C2-HC type zinc finger protein C.e-MyT1 | 0.0063 | 0.014 | 0.0457 |
Schistosoma mansoni | thyroid hormone receptor | 0.0023 | 0.0019 | 0.0148 |
Brugia malayi | acyl-CoA desaturase | 0.103 | 0.306 | 1 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0023 | 0.0019 | 0.0148 |
Wolbachia endosymbiont of Brugia malayi | 3-oxoacyl-ACP synthase | 0.3327 | 1 | 0.5 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0023 | 0.0019 | 0.0186 |
Echinococcus granulosus | intermediate filament protein | 0.0031 | 0.0044 | 0.0512 |
Echinococcus multilocularis | SAM and MBT domain containing protein | 0.0055 | 0.0117 | 0.0417 |
Leishmania major | fatty acid desaturase, putative | 0.0272 | 0.0771 | 0.1987 |
Onchocerca volvulus | 0.1302 | 0.3882 | 1 | |
Echinococcus multilocularis | lamin dm0 | 0.0031 | 0.0044 | 0.0146 |
Brugia malayi | Fatty acid desaturase family protein | 0.0272 | 0.0771 | 0.252 |
Echinococcus granulosus | lamin | 0.0031 | 0.0044 | 0.0512 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0023 | 0.0019 | 0.0062 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0023 | 0.0019 | 0.0062 |
Leishmania major | fatty acid desaturase, putative,sphingolipid delta 4 desaturase, putative | 0.0272 | 0.0771 | 0.1987 |
Loa Loa (eye worm) | FAT-3 protein | 0.0272 | 0.0771 | 0.252 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0023 | 0.0019 | 0.0186 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0058 | 0.0124 | 0.0406 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0023 | 0.0019 | 0.0148 |
Echinococcus multilocularis | Fatty acid desaturase, type 1 | 0.0272 | 0.0771 | 0.2859 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0053 | 0.011 | 0.0359 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0023 | 0.0019 | 0.0186 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0023 | 0.0019 | 0.0148 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.