Detailed information for compound 951862

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 1921.29 | Formula: C84H125N23O21S4
  • H donors: 22 H acceptors: 21 LogP: -4.69 Rotable bonds: 26
    Rule of 5 violations (Lipinski): 4
  • SMILES: CSCC[C@@H]1NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](NC(=O)[C@@H]2CCCN2C(=O)[C@@H](NC(=O)[C@H](CSCc2cc3CSC[C@H](NC1=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H]([C@H](CC)C)C(=O)N[C@@H](CC(=O)O)C(=O)NCC(=O)N1[C@H](C(=O)N[C@@H](CSCc(c3)c2)C(=O)NCC(=O)N)CCC1)NC(=O)[C@@H](N)C)C)Cc1c[nH]c2c1cccc2)[C@H](O)C
  • InChi: 1S/C84H125N23O21S4/c1-9-42(4)67-81(126)100-57(31-66(112)113)70(115)93-34-65(111)106-22-13-18-61(106)79(124)103-58(71(116)92-33-64(87)110)38-130-35-46-26-47-28-48(27-46)37-132-40-60(78(123)97-54(25-41(2)3)74(119)98-56(30-63(86)109)76(121)104-67)102-72(117)53(20-24-129-8)96-82(127)68(45(7)108)105-73(118)52(17-12-21-90-84(88)89)95-75(120)55(29-49-32-91-51-16-11-10-15-50(49)51)99-80(125)62-19-14-23-107(62)83(128)44(6)94-77(122)59(39-131-36-47)101-69(114)43(5)85/h10-11,15-16,26-28,32,41-45,52-62,67-68,91,108H,9,12-14,17-25,29-31,33-40,85H2,1-8H3,(H2,86,109)(H2,87,110)(H,92,116)(H,93,115)(H,94,122)(H,95,120)(H,96,127)(H,97,123)(H,98,119)(H,99,125)(H,100,126)(H,101,114)(H,102,117)(H,103,124)(H,104,121)(H,105,118)(H,112,113)(H4,88,89,90)/t42-,43-,44-,45+,52-,53-,54-,55-,56-,57-,58-,59-,60-,61-,62-,67-,68-/m0/s1
  • InChiKey: RVUOJQLUUJHGMT-IXAMDXIDSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.001 0.0085 0.0185
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0094 0.156 0.1556
Echinococcus multilocularis aldehyde reductase 0.0067 0.108 0.1075
Trichomonas vaginalis aldo-keto reductase, putative 0.0094 0.156 0.3583
Echinococcus granulosus bloom syndrome protein 0.0022 0.0292 0.0287
Brugia malayi PAN domain containing protein 0.0023 0.0307 0.0696
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0166 0.2836 1
Trichomonas vaginalis DNA helicase recq, putative 0.0022 0.0292 0.0662
Schistosoma mansoni blooms syndrome DNA helicase 0.0017 0.021 0.021
Schistosoma mansoni hypothetical protein 0.001 0.0086 0.0086
Loa Loa (eye worm) MH1 domain-containing protein 0.0007 0.0034 0.0067
Brugia malayi cytoplasmic intermediate filament protein 0.0012 0.0113 0.025
Trypanosoma brucei unspecified product 0.0034 0.0497 0.2666
Onchocerca volvulus 0.0023 0.0307 0.1067
Trichomonas vaginalis aldo-keto reductase, putative 0.0027 0.0382 0.0869
Trichomonas vaginalis aldo-keto reductase, putative 0.0094 0.156 0.3583
Toxoplasma gondii microneme protein, putative 0.0023 0.0307 0.0424
Schistosoma mansoni aldo-keto reductase 0.0094 0.156 0.156
Giardia lamblia DINP protein human, muc B family 0.0055 0.0872 0.5403
Brugia malayi MH2 domain containing protein 0.0007 0.0034 0.0067
Echinococcus multilocularis dna polymerase eta 0.0072 0.1179 0.1174
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0049 0.0765 0.0765
Trypanosoma cruzi PAB1-binding protein , putative 0.0023 0.0312 0.1973
Schistosoma mansoni microtubule-associated protein tau 0.0572 1 1
Brugia malayi intermediate filament protein 0.0022 0.0297 0.0672
Brugia malayi glutamate-cysteine ligase modifier subunit 0.0027 0.0382 0.0869
Trypanosoma cruzi DNA damage repair protein, putative 0.0015 0.017 0.106
Echinococcus granulosus hypothetical protein 0.0094 0.156 0.1556
Schistosoma mansoni ras GTP exchange factor son of sevenless 0.0006 0.0005 0.0005
Leishmania major aldo/keto reductase, putative,aldo/keto reductase family-like protein 0.0027 0.0382 0.1875
Mycobacterium tuberculosis Probable oxidoreductase 0.0094 0.156 1
Echinococcus multilocularis voltage gated potassium channel subunit 0.0027 0.0382 0.0377
Brugia malayi Intermediate filament tail domain containing protein 0.0022 0.0297 0.0672
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0039 0.0584 0.0874
Loa Loa (eye worm) glutaminase 0.0251 0.4345 1
Loa Loa (eye worm) hypothetical protein 0.0009 0.0063 0.0134
Loa Loa (eye worm) DIX domain-containing protein 0.0008 0.0046 0.0096
Brugia malayi acetyltransferase, GNAT family protein 0.0084 0.1394 0.3201
Schistosoma mansoni ras GTP exchange factor son of sevenless 0.0006 0.0005 0.0005
Loa Loa (eye worm) RecQ helicase 0.0022 0.0292 0.0662
Echinococcus granulosus lamin 0.0022 0.0297 0.0292
Echinococcus granulosus Smad4 0.0007 0.0034 0.0029
Brugia malayi MH2 domain containing protein 0.0007 0.0034 0.0067
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0025 0.0341 0.0479
Trypanosoma brucei DNA polymerase IV, putative 0.0073 0.1197 0.7495
Brugia malayi DIX domain containing protein 0.0008 0.0046 0.0096
Brugia malayi Flap endonuclease-1 0.0024 0.0325 0.0738
Loa Loa (eye worm) PAN domain-containing protein 0.0023 0.0307 0.0696
Onchocerca volvulus 0.0022 0.0297 0.103
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0055 0.0872 0.5253
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0012 0.0113 0.025
Onchocerca volvulus 0.0023 0.0307 0.1067
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0011 0.0093 0.0088
Echinococcus multilocularis aldo keto reductase 0.0094 0.156 0.1556
Echinococcus multilocularis smad 0.0007 0.0034 0.0029
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0024 0.0325 0.0453
Onchocerca volvulus 0.0008 0.0046 0.0146
Echinococcus granulosus aldo keto reductase family 1, member B4 0.0027 0.0382 0.0377
Onchocerca volvulus 0.0023 0.0307 0.1067
Loa Loa (eye worm) hypothetical protein 0.0094 0.156 0.3583
Plasmodium falciparum ataxin-2 like protein, putative 0.0023 0.0312 0.779
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0009 0.0063 0.0058
Trypanosoma cruzi PAB1-binding protein , putative 0.0023 0.0312 0.1973
Onchocerca volvulus 0.0094 0.156 0.5492
Trypanosoma brucei DNA damage repair protein, putative 0.0015 0.017 0.0409
Onchocerca volvulus 0.0023 0.0307 0.1067
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0008 0.0046 0.0096
Onchocerca volvulus Segment polarity protein dishevelled homolog 0.0008 0.0046 0.0146
Trichomonas vaginalis glutaminase, putative 0.0251 0.4345 1
Brugia malayi Smad1 0.0007 0.0034 0.0067
Trypanosoma cruzi hypothetical protein, conserved 0.0015 0.017 0.106
Trypanosoma cruzi DNA polymerase kappa, putative 0.0073 0.1197 0.7665
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0049 0.0765 0.175
Trypanosoma brucei DNA polymerase kappa, putative 0.0073 0.1197 0.7495
Schistosoma mansoni DNA helicase recq1 0.0009 0.0063 0.0063
Plasmodium vivax ataxin-2 like protein, putative 0.0023 0.0312 0.6741
Plasmodium falciparum aldehyde reductase, putative 0.0027 0.0382 1
Loa Loa (eye worm) hypothetical protein 0.0022 0.0297 0.0672
Brugia malayi N-terminal motif family protein 0.0166 0.2836 0.6523
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0008 0.0046 0.0096
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0009 0.0063 0.0058
Trypanosoma brucei aldo-keto reductase, putative 0.0094 0.156 1
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0382 0.0869
Trichomonas vaginalis aldo-keto reductase, putative 0.0094 0.156 0.3583
Trypanosoma brucei DNA damage repair protein, putative 0.0015 0.017 0.0409
Brugia malayi PAN domain containing protein 0.0023 0.0307 0.0696
Onchocerca volvulus 0.0023 0.0307 0.1067
Toxoplasma gondii aldose reductase, putative 0.0094 0.156 0.2461
Schistosoma mansoni guanine-nucleotide-exchange-factor 0.0006 0.0005 0.0005
Echinococcus granulosus aldo keto reductase 0.0094 0.156 0.1556
Loa Loa (eye worm) hypothetical protein 0.0008 0.0046 0.0096
Loa Loa (eye worm) hypothetical protein 0.004 0.0602 0.1375
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0094 0.156 0.1556
Loa Loa (eye worm) hypothetical protein 0.0011 0.0093 0.0202
Plasmodium falciparum DNA repair protein REV1, putative 0.0015 0.017 0.3342
Leishmania major prostaglandin f2-alpha synthase/D-arabinose dehydrogenase 0.0094 0.156 1
Echinococcus granulosus aldo keto reductase 0.0094 0.156 0.1556
Trypanosoma brucei DNA polymerase IV, putative 0.0067 0.109 0.6755
Trypanosoma brucei unspecified product 0.0067 0.109 0.6755
Entamoeba histolytica alcohol dehydrogenase, putative 0.0027 0.0382 0.2426
Loa Loa (eye worm) hypothetical protein 0.0111 0.1866 0.4288
Leishmania major DNA polymerase kappa, putative 0.0015 0.017 0.0409
Loa Loa (eye worm) hypothetical protein 0.0023 0.0307 0.0696
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0094 0.156 0.1556
Toxoplasma gondii PAN domain-containing protein 0.0356 0.6196 1
Schistosoma mansoni dishevelled 0.0008 0.0046 0.0046
Entamoeba histolytica recQ family helicase, putative 0.0012 0.0111 0.0678
Onchocerca volvulus 0.0094 0.156 0.5492
Toxoplasma gondii aldo-keto reductase 0.0027 0.0382 0.0546
Entamoeba histolytica aldose reductase, putative 0.0094 0.156 1
Echinococcus multilocularis lamin 0.0022 0.0297 0.0292
Trichomonas vaginalis aldo-keto reductase, putative 0.0027 0.0382 0.0869
Trichomonas vaginalis DNA helicase recq1, putative 0.0022 0.0292 0.0662
Echinococcus granulosus smad 0.0007 0.0034 0.0029
Schistosoma mansoni Smad4 0.0007 0.0034 0.0034
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0094 0.156 0.3583
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0024 0.0325 0.1482
Echinococcus multilocularis dna polymerase kappa 0.0073 0.1197 0.1192
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0602 0.3391
Toxoplasma gondii PAN domain-containing protein 0.0023 0.0307 0.0424
Toxoplasma gondii PAN domain-containing protein 0.0023 0.0307 0.0424
Brugia malayi hypothetical protein 0.0023 0.0312 0.0707
Trichomonas vaginalis aldo-keto reductase, putative 0.0094 0.156 0.3583
Plasmodium falciparum ataxin-2 like protein, putative 0.0023 0.0312 0.779
Schistosoma mansoni z-protein (S1r protein) 0.0008 0.0046 0.0046
Trypanosoma brucei hypothetical protein, conserved 0.0015 0.017 0.0409
Schistosoma mansoni smad1 5 8 and 0.0007 0.0034 0.0034
Trichomonas vaginalis aldo/keto reductase, putative 0.0094 0.156 0.3583
Loa Loa (eye worm) hypothetical protein 0.0023 0.0307 0.0696
Echinococcus granulosus aldo keto reductase 0.0094 0.156 0.1556
Toxoplasma gondii microneme protein MIC17C 0.0023 0.0307 0.0424
Trichomonas vaginalis aldo-keto reductase, putative 0.0094 0.156 0.3583
Schistosoma mansoni aldo-keto reductase 0.0094 0.156 0.156
Mycobacterium tuberculosis Conserved protein 0.0027 0.0382 0.2405
Loa Loa (eye worm) hypothetical protein 0.0023 0.0307 0.0696
Schistosoma mansoni DNA polymerase eta 0.0072 0.1179 0.1179
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0084 0.1394 0.1394
Echinococcus granulosus dna polymerase kappa 0.0073 0.1197 0.1192
Onchocerca volvulus 0.0023 0.0307 0.1067
Trichomonas vaginalis aldo-keto reductase, putative 0.0094 0.156 0.3583
Echinococcus multilocularis flap endonuclease 1 0.0024 0.0325 0.032
Mycobacterium tuberculosis Conserved hypothetical protein 0.0049 0.0765 0.4871
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0094 0.156 0.1556
Echinococcus granulosus mothers against decapentaplegic 5 0.0007 0.0034 0.0029
Schistosoma mansoni smad1 5 8 and 0.0007 0.0034 0.0034
Onchocerca volvulus 0.0094 0.156 0.5492
Echinococcus multilocularis aldo keto reductase 0.0094 0.156 0.1556
Schistosoma mansoni fyve finger-containing phosphoinositide kinase fyv1 0.0008 0.0046 0.0046
Trypanosoma brucei DNA polymerase kappa, putative 0.0073 0.1197 0.7495
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0009 0.0063 0.0134
Echinococcus granulosus intermediate filament protein 0.0022 0.0297 0.0292
Trypanosoma brucei aldo/keto reductase, putative 0.0027 0.0382 0.1875
Giardia lamblia Histone acetyltransferase GCN5 0.0023 0.0304 0.1611
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0025 0.0341 0.0479
Onchocerca volvulus 0.0023 0.0307 0.1067
Loa Loa (eye worm) hypothetical protein 0.0072 0.1179 0.2704
Trypanosoma brucei DNA polymerase kappa, putative 0.0073 0.1197 0.7495
Toxoplasma gondii microneme protein MIC17A 0.0023 0.0307 0.0424
Trypanosoma brucei DNA polymerase kappa, putative 0.0073 0.1197 0.7495
Schistosoma mansoni pol-related 0.0094 0.156 0.156
Trypanosoma cruzi aldo/keto reductase, putative 0.0094 0.156 1
Echinococcus multilocularis aldo keto reductase 0.0094 0.156 0.1556
Brugia malayi PAN domain containing protein 0.0023 0.0307 0.0696
Trypanosoma brucei chrX additional, unordered contigs 0.0015 0.017 0.0409
Giardia lamblia Flap structure-specific endonuclease 0.0024 0.0325 0.1752
Brugia malayi MH2 domain containing protein 0.011 0.1842 0.4234
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0009 0.0063 0.0058
Trichomonas vaginalis aldo-keto reductase, putative 0.0094 0.156 0.3583
Schistosoma mansoni DNA polymerase IV / kappa 0.0015 0.017 0.017
Schistosoma mansoni ras GTP exchange factor son of sevenless 0.0006 0.0005 0.0005
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0084 0.1394 0.139
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0094 0.156 0.1556
Loa Loa (eye worm) oxidoreductase 0.0094 0.156 0.3583
Schistosoma mansoni DNA helicase recq5 0.0009 0.0063 0.0063
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0008 0.0046 0.0096
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0094 0.156 0.1556
Loa Loa (eye worm) oxidoreductase 0.0094 0.156 0.3583
Entamoeba histolytica deoxycytidyl transferase, putative 0.0049 0.0765 0.4885
Entamoeba histolytica Flap nuclease, putative 0.0024 0.0325 0.206
Echinococcus granulosus Pleckstrin G protein interacting region 0.0008 0.0046 0.0041
Giardia lamblia Aldose reductase 0.0094 0.156 1
Echinococcus granulosus aldehyde reductase 0.0067 0.108 0.1075
Schistosoma mansoni glutaminase 0.0251 0.4345 0.4345
Mycobacterium leprae Conserved hypothetical protein 0.0067 0.108 0.5922
Schistosoma mansoni potassium channel beta 0.0027 0.0382 0.0382
Echinococcus multilocularis segment polarity protein dishevelled 0.0008 0.0046 0.0041
Loa Loa (eye worm) hypothetical protein 0.0023 0.0307 0.0696
Leishmania major DNA polymerase kappa, putative 0.0055 0.0872 0.5253
Brugia malayi ImpB/MucB/SamB family protein 0.0049 0.0765 0.175
Loa Loa (eye worm) MH2 domain-containing protein 0.011 0.1842 0.4234
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0049 0.0765 0.076
Trypanosoma brucei unspecified product 0.0034 0.0497 0.2666
Plasmodium vivax DNA repair protein REV1, putative 0.0015 0.017 0.018
Trypanosoma brucei DNA polymerase kappa, putative 0.0073 0.1197 0.7495
Brugia malayi MH1 domain containing protein 0.0007 0.0034 0.0067
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0012 0.0111 0.0678
Loa Loa (eye worm) intermediate filament protein 0.0022 0.0297 0.0672
Echinococcus multilocularis bloom syndrome protein 0.0022 0.0292 0.0287
Trichomonas vaginalis aldo/keto reductase, putative 0.0094 0.156 0.3583
Echinococcus granulosus lamin dm0 0.0022 0.0297 0.0292
Trypanosoma brucei DNA polymerase eta, putative 0.0072 0.1179 0.737
Echinococcus granulosus segment polarity protein dishevelled 0.0008 0.0046 0.0041
Schistosoma mansoni dep domain containing protein 0.0008 0.0046 0.0046
Schistosoma mansoni smad1 5 8 and 0.0007 0.0034 0.0034
Mycobacterium ulcerans oxidoreductase 0.0094 0.156 0.3329
Schistosoma mansoni flap endonuclease-1 0.0022 0.0285 0.0285
Echinococcus multilocularis regulator of G protein signaling 7 0.0008 0.0046 0.0041
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0094 0.156 0.1556
Onchocerca volvulus 0.0023 0.0307 0.1067
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0022 0.0297 0.0672
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0011 0.0093 0.0088
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0094 0.156 0.1556
Toxoplasma gondii subtilisin SUB12 0.0023 0.0307 0.0424
Trichomonas vaginalis aldo/keto reductase, putative 0.0094 0.156 0.3583
Loa Loa (eye worm) acetyltransferase 0.0084 0.1394 0.3201
Trypanosoma brucei DNA polymerase kappa, putative 0.0073 0.1197 0.7495
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0024 0.0325 0.1482
Onchocerca volvulus 0.0022 0.0297 0.103
Leishmania major DNA polymerase eta, putative 0.0039 0.0584 0.3265
Toxoplasma gondii PAN domain-containing protein 0.0023 0.0307 0.0424
Onchocerca volvulus 0.0023 0.0307 0.1067
Loa Loa (eye worm) hypothetical protein 0.0022 0.0289 0.0655
Echinococcus multilocularis lamin dm0 0.0022 0.0297 0.0292
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0009 0.0063 0.0058
Trypanosoma cruzi DNA polymerase kappa, putative 0.0073 0.1197 0.7665
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0007 0.0034 0.0029
Schistosoma mansoni regulator of G protein signaling 0.0008 0.0046 0.0046
Loa Loa (eye worm) PAN domain-containing protein 0.0023 0.0307 0.0696
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.001 0.0086 0.0081
Echinococcus multilocularis mothers against decapentaplegic 5 0.0007 0.0034 0.0029
Trichomonas vaginalis aldo-keto reductase, putative 0.0094 0.156 0.3583
Leishmania major aldo-keto reductase-like protein 0.0094 0.156 1
Echinococcus granulosus regulator of G protein signaling 7 0.0008 0.0046 0.0041
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0015 0.017 0.0201
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0604 0.3406
Toxoplasma gondii PAN domain-containing protein 0.0023 0.0307 0.0424
Brugia malayi hypothetical protein 0.0015 0.0167 0.0372
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0094 0.156 0.3583
Trichomonas vaginalis aldo-keto reductase, putative 0.0094 0.156 0.3583
Giardia lamblia DNA damage repair protein 0.0015 0.017 0.0713
Entamoeba histolytica alcohol dehydrogenase, putative 0.0027 0.0382 0.2426
Leishmania major DNA damage repair protein, putative 0.0015 0.017 0.0409
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0094 0.156 0.3583
Onchocerca volvulus 0.0023 0.0307 0.1067
Trichomonas vaginalis aldo-keto reductase, putative 0.0094 0.156 0.3583
Loa Loa (eye worm) oxidoreductase 0.0094 0.156 0.3583
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0015 0.0163 0.0189
Trypanosoma cruzi aldo/keto reductase, putative 0.0027 0.0382 0.2426
Plasmodium vivax oxidoreductase, aldo/keto reductase domain containing protein 0.0027 0.0382 1
Onchocerca volvulus 0.0094 0.156 0.5492
Mycobacterium ulcerans DNA polymerase IV 0.0073 0.1197 0.246
Loa Loa (eye worm) Smad1 0.0007 0.0034 0.0067
Toxoplasma gondii PAN/Apple domain-containing protein 0.0023 0.0307 0.0424
Trypanosoma brucei DNA polymerase IV, putative 0.0073 0.1197 0.7495
Onchocerca volvulus 0.0023 0.0307 0.1067
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0094 0.156 0.3583
Onchocerca volvulus 0.0094 0.156 0.5492
Echinococcus multilocularis dnaJ subfamily C 6 0.0056 0.0898 0.0893
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0009 0.0063 0.0134
Echinococcus granulosus histone acetyltransferase KAT2B 0.0082 0.1352 0.1348
Trichomonas vaginalis DNA helicase recq, putative 0.0012 0.0111 0.0243
Schistosoma mansoni smad 0.0007 0.0034 0.0034
Plasmodium vivax aldehyde reductase, putative 0.0027 0.0382 1
Echinococcus multilocularis Smad4 0.0007 0.0034 0.0029
Leishmania major aldehyde reductase, putative,oxidoreductase, putative 0.0094 0.156 1
Loa Loa (eye worm) hypothetical protein 0.0023 0.0307 0.0696
Brugia malayi hypothetical protein 0.0008 0.0046 0.0096
Plasmodium falciparum flap endonuclease 1 0.0024 0.0325 0.8216
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0094 0.156 0.1556
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0094 0.156 0.1556
Loa Loa (eye worm) glutamate-cysteine ligase modifier subunit 0.0027 0.0382 0.0869
Leishmania major prostaglandin f synthase, putative 0.0094 0.156 1
Echinococcus multilocularis musashi 0.0022 0.0297 0.0292
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0094 0.156 0.3583
Trypanosoma cruzi hypothetical protein, conserved 0.0015 0.017 0.106
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0094 0.156 0.1556
Trypanosoma cruzi DNA polymerase kappa, putative 0.0073 0.1197 0.7665
Onchocerca volvulus 0.0027 0.0382 0.1332
Brugia malayi NADH-dependent xylose reductase 0.0027 0.0382 0.0869
Loa Loa (eye worm) PAN domain-containing protein 0.0023 0.0307 0.0696
Brugia malayi hypothetical protein 0.0008 0.0046 0.0096
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0009 0.0063 0.0027
Echinococcus granulosus segment polarity protein dishevelled 0.0008 0.0046 0.0041
Mycobacterium ulcerans glutaminase 0.0251 0.4345 1
Toxoplasma gondii microneme protein MIC4 0.0023 0.0307 0.0424
Trypanosoma brucei hypothetical protein, conserved 0.0015 0.017 0.0409
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0025 0.0341 0.0774
Entamoeba histolytica acetyltransferase, GNAT family 0.0023 0.0304 0.1925
Trypanosoma brucei DNA polymerase kappa, putative 0.0073 0.1197 0.7495
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0024 0.0325 0.206
Loa Loa (eye worm) hypothetical protein 0.0023 0.0307 0.0696
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0073 0.1197 0.2746
Schistosoma mansoni ras GTP exchange factor 0.0006 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0023 0.0312 0.0707
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0007 0.0034 0.0034
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0094 0.156 0.1556
Loa Loa (eye worm) hypothetical protein 0.0166 0.2836 0.6523
Loa Loa (eye worm) hypothetical protein 0.0008 0.0046 0.0096
Echinococcus granulosus histone acetyltransferase KAT2B 0.0025 0.0341 0.0336
Plasmodium falciparum histone acetyltransferase GCN5 0.0023 0.0304 0.7556
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0094 0.156 0.1556
Echinococcus multilocularis aldo keto reductase 0.0094 0.156 0.1556
Echinococcus granulosus voltage gated potassium channel subunit 0.0027 0.0382 0.0377
Loa Loa (eye worm) MH2 domain-containing protein 0.0007 0.0034 0.0067
Brugia malayi DnaJ domain containing protein 0.0056 0.0898 0.2057
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0049 0.0765 0.076
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0009 0.0063 0.0134
Schistosoma mansoni lamin 0.0022 0.0297 0.0297
Mycobacterium ulcerans hypothetical protein 0.0027 0.0382 0.0509
Mycobacterium leprae PROBABLE OXIDOREDUCTASE 0.0094 0.156 1
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0604 0.3406
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0604 0.3406
Loa Loa (eye worm) oxidoreductase 0.0094 0.156 0.3583
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0094 0.156 0.1556
Echinococcus granulosus dnaJ subfamily C 6 0.0056 0.0898 0.0893
Brugia malayi PAN domain containing protein 0.0023 0.0307 0.0696
Loa Loa (eye worm) hypothetical protein 0.0023 0.0307 0.0696
Entamoeba histolytica aldose reductase, putative 0.0094 0.156 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0073 0.1197 0.7495
Brugia malayi PAN domain containing protein 0.0023 0.0307 0.0696
Trichomonas vaginalis aldo-keto reductase, putative 0.0094 0.156 0.3583
Schistosoma mansoni dishevelled 0.0008 0.0046 0.0046
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0021 0.0277 0.0375
Trichomonas vaginalis DNA polymerase eta, putative 0.0073 0.1197 0.2746
Loa Loa (eye worm) PAN domain-containing protein 0.0023 0.0307 0.0696
Echinococcus multilocularis microtubule associated protein 2 0.0572 1 1
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0019 0.0245 0.5694
Trichomonas vaginalis flap endonuclease-1, putative 0.0024 0.0325 0.0738
Trypanosoma brucei PAB1-binding protein , putative 0.0023 0.0312 0.1388
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0094 0.156 0.3583
Entamoeba histolytica aldose reductase, putative 0.0094 0.156 1
Echinococcus multilocularis Pleckstrin G protein, interacting region 0.0008 0.0046 0.0041
Echinococcus granulosus flap endonuclease 1 0.0024 0.0325 0.032
Echinococcus granulosus TGF beta signal transducer SmadC 0.0007 0.0034 0.0029
Echinococcus multilocularis segment polarity protein dishevelled 0.0008 0.0046 0.0041
Echinococcus granulosus dna polymerase eta 0.0072 0.1179 0.1174
Loa Loa (eye worm) transcription factor SMAD2 0.011 0.1842 0.4234
Brugia malayi ImpB/MucB/SamB family protein 0.0072 0.1179 0.2704
Plasmodium vivax flap endonuclease 1, putative 0.0024 0.0325 0.7368
Toxoplasma gondii aldo/keto reductase family oxidoreductase 0.0027 0.0382 0.0546
Schistosoma mansoni intermediate filament proteins 0.0022 0.0297 0.0297
Trypanosoma cruzi DNA damage repair protein, putative 0.0015 0.017 0.106
Brugia malayi PAN domain containing protein 0.0023 0.0307 0.0696
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0055 0.0872 0.5563
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0094 0.156 0.1556
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.001 0.0086 0.0081
Echinococcus granulosus regulator of G protein signaling 7 0.0008 0.0046 0.0041
Trichomonas vaginalis aldo-keto reductase, putative 0.0027 0.0382 0.0869
Trypanosoma cruzi aldo-keto reductase 0.0094 0.156 1
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0094 0.156 0.1556
Plasmodium falciparum aldo-keto reductase, putative 0.0027 0.0382 1
Trypanosoma brucei prostaglandin f synthase 0.0094 0.156 1
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0025 0.0341 0.8085
Leishmania major hypothetical protein, conserved 0.0023 0.0312 0.1388
Trypanosoma brucei DNA polymerase kappa, putative 0.0073 0.1197 0.7495
Loa Loa (eye worm) PAN domain-containing protein 0.0023 0.0307 0.0696
Loa Loa (eye worm) DnaJ domain-containing protein 0.0056 0.0898 0.2057
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0602 0.3391
Trichomonas vaginalis aldo-keto reductase, putative 0.0094 0.156 0.3583
Trichomonas vaginalis alcohol dehydrogenase, putative 0.0027 0.0382 0.0869
Trichomonas vaginalis protein kinase inhibitor, putative 0.0056 0.0898 0.2057
Loa Loa (eye worm) glutaminase 2 0.0251 0.4345 1
Brugia malayi polk-prov protein 0.004 0.0602 0.1375
Leishmania major DNA polymerase eta, putative 0.0072 0.1179 0.737
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0009 0.0063 0.0027
Onchocerca volvulus 0.0094 0.156 0.5492
Brugia malayi Bloom's syndrome protein homolog 0.0022 0.0292 0.0662
Toxoplasma gondii oxidoreductase, aldo/keto reductase family protein 0.0027 0.0382 0.0546
Brugia malayi PAN domain containing protein 0.0023 0.0307 0.0696
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0094 0.156 0.1556
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0094 0.156 0.1556
Trypanosoma cruzi DNA polymerase eta, putative 0.0072 0.1179 0.7548
Brugia malayi regulator of G-protein signaling egl-10 0.0008 0.0046 0.0096
Toxoplasma gondii hypothetical protein 0.0023 0.0307 0.0424
Loa Loa (eye worm) oxidoreductase 0.0094 0.156 0.3583
Schistosoma mansoni hypothetical protein 0.0056 0.0898 0.0898
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0094 0.156 0.3583
Toxoplasma gondii 1,3(4)-beta-glucanase 0.0023 0.0307 0.0424
Trypanosoma cruzi DNA polymerase kappa, putative 0.0073 0.1197 0.7665
Toxoplasma gondii LsmAD domain-containing protein 0.0023 0.0312 0.0431
Toxoplasma gondii hypothetical protein 0.0023 0.0307 0.0424
Giardia lamblia Aldose reductase 0.0094 0.156 1
Mycobacterium ulcerans DNA polymerase IV 0.0073 0.1197 0.246
Brugia malayi glutaminase DH11.1 0.0251 0.4345 1
Brugia malayi PAN domain containing protein 0.0023 0.0307 0.0696
Toxoplasma gondii microneme protein MIC17B 0.0023 0.0307 0.0424
Toxoplasma gondii PAN domain-containing protein 0.0356 0.6196 1
Echinococcus multilocularis regulator of G protein signaling 7 0.0008 0.0046 0.0041
Loa Loa (eye worm) hypothetical protein 0.0008 0.0046 0.0096
Trichomonas vaginalis bromodomain-containing protein, putative 0.0025 0.0341 0.0774
Brugia malayi MH1 domain containing protein 0.0007 0.0034 0.0067
Trypanosoma brucei DNA polymerase kappa, putative 0.0055 0.0872 0.5253
Trypanosoma cruzi DNA polymerase eta, putative 0.0039 0.0584 0.3722
Brugia malayi PAN domain containing protein 0.0023 0.0307 0.0696
Loa Loa (eye worm) flap endonuclease-1 0.0024 0.0325 0.0738
Schistosoma mansoni terminal deoxycytidyl transferase 0.0049 0.0765 0.0765
Schistosoma mansoni lamin 0.0022 0.0297 0.0297
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0094 0.156 0.1556
Loa Loa (eye worm) hypothetical protein 0.001 0.0085 0.0185
Brugia malayi PAN domain containing protein 0.0023 0.0307 0.0696
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0094 0.156 0.1556

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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