Detailed information for compound 971800

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 448.506 | Formula: C24H32O8
  • H donors: 3 H acceptors: 5 LogP: 1.43 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(=O)O[C@H]1CC[C@]([C@@]23[C@]1(C)[C@@H](OC(=O)c1ccccc1)[C@@H](O)[C@H]([C@H]3O)C(O2)(C)C)(C)O
  • InChi: 1S/C24H32O8/c1-13(25)30-15-11-12-22(4,29)24-18(27)16(21(2,3)32-24)17(26)19(23(15,24)5)31-20(28)14-9-7-6-8-10-14/h6-10,15-19,26-27,29H,11-12H2,1-5H3/t15-,16+,17-,18+,19-,22-,23-,24-/m0/s1
  • InChiKey: CMSNKLSCKFKAGB-HPYSGJSDSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi cytoplasmic intermediate filament protein 0.0029 0.0248 0.0508
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0043 0.0427 0.1254
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0092 0.027
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.003 0.0261 0.6833
Trypanosoma cruzi cytochrome P450, putative 0.0012 0.0042 0.0078
Mycobacterium tuberculosis Probable oxidoreductase 0.0117 0.1332 0.4057
Entamoeba histolytica acyl-coA synthetase, putative 0.0049 0.0497 0.1462
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0092 0.0235
Schistosoma mansoni dihydrofolate reductase 0.0115 0.1314 0.409
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.0092 0.0234
Echinococcus granulosus histone lysine methyltransferase setb 0.0058 0.0609 0.1551
Trichomonas vaginalis adenylate cyclase, putative 0.0012 0.0046 0.0027
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0058 0.0609 0.0608
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.0229 0.2706 0.839
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0014 0.0072 0.0172
Trichomonas vaginalis DNA helicase recq1, putative 0.0021 0.015 0.0214
Loa Loa (eye worm) CYP4Cod1 0.0012 0.0042 0.0087
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.0469 0.0792
Trypanosoma cruzi cytochrome P450, putative 0.0012 0.0042 0.0078
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0261 0.0416
Mycobacterium ulcerans acyl-CoA synthetase 0.0014 0.0072 0.0089
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0261 0.0416
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0012 0.0046 0.0091
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0035 0.032 0.0861
Onchocerca volvulus 0.0048 0.0485 0.0797
Loa Loa (eye worm) hypothetical protein 0.0049 0.0497 0.102
Loa Loa (eye worm) cytochrome P450 family protein 0.0012 0.0042 0.0087
Toxoplasma gondii NADPH-glutathione reductase 0.0016 0.0092 0.0268
Brugia malayi Intermediate filament tail domain containing protein 0.0053 0.0553 0.1135
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0049 0.0497 0.1354
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0014 0.0072 0.0182
Plasmodium falciparum thioredoxin reductase 0.0046 0.0462 0.1436
Loa Loa (eye worm) hypothetical protein 0.0014 0.0072 0.0148
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0016 0.0092 0.0148
Loa Loa (eye worm) hypothetical protein 0.0012 0.0046 0.0095
Trichomonas vaginalis guanylate cyclase, putative 0.0012 0.0046 0.0027
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0016 0.0092 0.0142
Brugia malayi Cytochrome P450 family protein 0.0012 0.0042 0.0086
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0012 0.0046 0.0027
Brugia malayi hypothetical protein 0.0021 0.015 0.0306
Toxoplasma gondii adenosylhomocysteinase, putative 0.027 0.3213 0.945
Onchocerca volvulus 0.0021 0.015 0.0188
Leishmania major protein kinase, putative 0.0012 0.0046 0.0091
Loa Loa (eye worm) hypothetical protein 0.0037 0.0345 0.0708
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0092 0.0234
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0014 0.0072 0.0077
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0685 0.213
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0092 0.0092
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0069 0.0747 0.1533
Plasmodium falciparum LCCL domain-containing protein 0.0021 0.015 0.0464
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0014 0.0072 0.0077
Onchocerca volvulus 0.0014 0.0072 0.0047
Plasmodium falciparum acyl-CoA synthetase 0.0037 0.0345 0.1071
Loa Loa (eye worm) hypothetical protein 0.0021 0.015 0.0307
Mycobacterium ulcerans hypothetical protein 0.0049 0.0497 0.1354
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0012 0.0046 0.0091
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.002 0.0138 0.0283
Brugia malayi AMP-binding enzyme family protein 0.0014 0.0072 0.0147
Echinococcus granulosus adenosylhomocysteinase 0.027 0.3213 0.8186
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.003 0.0261 0.0812
Echinococcus multilocularis transfer RNA-Lys 0.0035 0.0325 0.0324
Mycobacterium ulcerans acetyl-CoA synthetase 0.0014 0.0072 0.0089
Echinococcus multilocularis RUN 0.0021 0.015 0.0149
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0016 0.0092 0.0234
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0037 0.0345 0.0901
Schistosoma mansoni adenosylhomocysteinase 0.0167 0.1948 0.6064
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0012 0.004 0.008
Entamoeba histolytica acyl-CoA synthetase, putative 0.0049 0.0497 0.1462
Echinococcus multilocularis thioredoxin glutathione reductase 0.0046 0.0462 0.0461
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0011 0.0031 0.0045
Mycobacterium leprae DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) 0.0115 0.1314 0.4005
Brugia malayi Pre-SET motif family protein 0.0058 0.0609 0.125
Schistosoma mansoni lamin 0.0053 0.0553 0.172
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.0092 0.0234
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0043 0.0427 0.1254
Echinococcus granulosus lamin dm0 0.0053 0.0553 0.1408
Brugia malayi RNA recognition motif domain containing protein 0.0064 0.0685 0.1405
Brugia malayi RNA binding protein 0.0064 0.0685 0.1405
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0012 0.0046 0.0027
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0685 0.213
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0012 0.0046 0.0091
Mycobacterium ulcerans acyl-CoA synthetase 0.0049 0.0497 0.1354
Plasmodium vivax acetyl-CoA synthetase, putative 0.0014 0.0072 0.0014
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0261 0.0416
Brugia malayi AMP-binding enzyme family protein 0.0014 0.0072 0.0147
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0261 0.0416
Toxoplasma gondii 3-methyl-2-oxobutanoate hydroxymethyltransferase 0.0285 0.34 1
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0049 0.0497 0.1419
Onchocerca volvulus 0.046 0.5557 1
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0053 0.0553 0.1136
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0026 0.0213 0.0541
Toxoplasma gondii S-Adenosyl homocysteine hydrolase 0.027 0.3213 0.945
Plasmodium vivax 6-phosphofructokinase, putative 0.003 0.0261 0.0616
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0069 0.0747 0.0746
Schistosoma mansoni adenosylhomocysteinase 0.0167 0.1948 0.6064
Mycobacterium tuberculosis Probable dehydrogenase 0.0105 0.1187 0.3601
Trypanosoma cruzi S-adenosylhomocysteine hydrolase, putative 0.027 0.3213 1
Loa Loa (eye worm) hypothetical protein 0.0158 0.1842 0.3781
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0012 0.0046 0.0091
Toxoplasma gondii propionate-CoA ligase 0.0014 0.0072 0.021
Loa Loa (eye worm) doublecortin family protein 0.0021 0.015 0.0307
Onchocerca volvulus 0.0021 0.015 0.0188
Trichomonas vaginalis conserved hypothetical protein 0.0285 0.34 0.6095
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase, putative 0.0054 0.0558 0.1692
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0016 0.0092 0.0148
Brugia malayi Isocitrate dehydrogenase 0.0016 0.0092 0.0189
Giardia lamblia NADH oxidase lateral transfer candidate 0.0016 0.0092 0.2389
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0014 0.0072 0.0089
Mycobacterium ulcerans acyl-CoA synthetase 0.0049 0.0497 0.1354
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.0092 0.0234
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.0072 0.0077
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0124 0.1416 0.3607
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0058 0.0609 0.1894
Loa Loa (eye worm) hypothetical protein 0.0009 0.0001 0.0001
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0117 0.1332 0.4059
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0.0092 0.0286
Loa Loa (eye worm) hypothetical protein 0.0049 0.0497 0.102
Toxoplasma gondii PPIC-type PPIASE domain-containing protein 0.001 0.0017 0.0049
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0016 0.0092 0.0187
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0014 0.0072 0.0148
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0012 0.004 0.008
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.0014 0.0072 0.0081
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0069 0.0747 0.2283
Echinococcus granulosus lamin 0.0053 0.0553 0.1408
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0049 0.0497 0.1354
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0058 0.0609 0.1894
Onchocerca volvulus 0.0053 0.0553 0.092
Trichomonas vaginalis phosphofructokinase, putative 0.011 0.125 0.2205
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0261 0.0416
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0012 0.0046 0.0091
Brugia malayi TAR-binding protein 0.0064 0.0685 0.1405
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.002 0.0138 0.0285
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.011 0.125 0.3858
Echinococcus multilocularis tumor protein p63 0.0328 0.3924 0.3924
Brugia malayi 6-phosphofructokinase 0.011 0.125 0.2566
Mycobacterium ulcerans 6-phosphofructokinase 0.011 0.125 0.3597
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0105 0.1187 0.3601
Schistosoma mansoni adenosylhomocysteinase 0.0167 0.1948 0.6064
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0404 0.487 1
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0105 0.1187 0.3604
Echinococcus granulosus dihydrofolate reductase 0.0115 0.1314 0.3348
Echinococcus multilocularis isocitrate dehydrogenase 0.0016 0.0092 0.0092
Plasmodium vivax 6-phosphofructokinase, putative 0.003 0.0261 0.0616
Loa Loa (eye worm) hypothetical protein 0.0048 0.0485 0.0996
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0014 0.0072 0.0077
Treponema pallidum exodeoxyribonuclease (exoA) 0.002 0.0138 0.0399
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0069 0.0747 0.2283
Echinococcus multilocularis transcription factor Dp 1 0.004 0.0388 0.0388
Mycobacterium ulcerans acyl-CoA synthetase 0.0014 0.0072 0.0089
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0014 0.0072 0.021
Brugia malayi hypoxia-induced factor 1 0.0146 0.1691 0.3471
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0032 0.0286 0.0842
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0033 0.0296 0.0606
Mycobacterium ulcerans acyl-CoA synthetase 0.0014 0.0072 0.0089
Loa Loa (eye worm) 6-phosphofructokinase 0.011 0.125 0.2567
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0049 0.0497 0.1354
Loa Loa (eye worm) RNA binding protein 0.0064 0.0685 0.1406
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0046 0.0027
Echinococcus granulosus transcription factor Dp 1 0.004 0.0388 0.0988
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0014 0.0072 0.0089
Loa Loa (eye worm) TAR-binding protein 0.0064 0.0685 0.1406
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0056 0.0583 0.1484
Echinococcus multilocularis dihydrofolate reductase 0.0115 0.1314 0.1314
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.0229 0.2706 0.8415
Brugia malayi hypothetical protein 0.0054 0.0558 0.1144
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.0072 0.0077
Toxoplasma gondii phosphofructokinase domain-containing protein 0.003 0.0261 0.0768
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0014 0.0072 0.0089
Entamoeba histolytica exodeoxyribonuclease III, putative 0.002 0.0138 0.0335
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0014 0.0072 0.0172
Leishmania major 4-coumarate:coa ligase-like protein 0.0049 0.0497 0.15
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0092 0.0234
Trypanosoma brucei cytochrome P450, putative 0.0012 0.0042 0.0078
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0046 0.0027
Plasmodium falciparum histone acetyltransferase GCN5 0.004 0.0382 0.1189
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0147 0.1702 0.1701
Mycobacterium tuberculosis Probable reductase 0.0105 0.1187 0.3601
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.002 0.0138 0.3599
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0014 0.0072 0.0077
Brugia malayi hypothetical protein 0.0021 0.015 0.0306
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0035 0.032 0.0861
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0092 0.027
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0069 0.0747 0.2323
Echinococcus multilocularis lamin dm0 0.0053 0.0553 0.0553
Brugia malayi AMP-binding enzyme family protein 0.0014 0.0072 0.0147
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0069 0.0747 0.1901
Schistosoma mansoni adenosylhomocysteinase 0.0167 0.1948 0.6064
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.0012 0.0046 0.0027
Brugia malayi acetyltransferase, GNAT family protein 0.0147 0.1702 0.3493
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0032 0.0286 0.0842
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.0092 0.0234
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0092 0.0235
Loa Loa (eye worm) intermediate filament protein 0.0053 0.0553 0.1136
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0069 0.0747 0.2283
Brugia malayi Doublecortin family protein 0.0021 0.015 0.0306
Brugia malayi AMP-binding enzyme family protein 0.0049 0.0497 0.1019
Trichomonas vaginalis phosphofructokinase, putative 0.011 0.125 0.2205
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.011 0.125 0.3799
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0014 0.0072 0.0147
Echinococcus granulosus 6 phosphofructokinase 0.011 0.125 0.3184
Mycobacterium leprae POSSIBLE FATTY-ACID-CoA LIGASE FADD10 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0014 0.0072 0.0081
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0016 0.0092 0.0235
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.002 0.0138 0.0286
Trypanosoma cruzi S-adenosylhomocysteine hydrolase, putative 0.027 0.3213 1
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0018 0.0119 0.0369
Echinococcus granulosus bloom syndrome protein 0.0021 0.015 0.0381
Entamoeba histolytica adenosylhomocysteinase, putative 0.027 0.3213 1
Loa Loa (eye worm) glutathione reductase 0.0046 0.0462 0.0948
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0009 0.0001 0.00000000014073
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0138 0.0193
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0016 0.0092 0.0079
Onchocerca volvulus 0.0113 0.1287 0.2252
Echinococcus granulosus thioredoxin glutathione reductase 0.0046 0.0462 0.1176
Trichomonas vaginalis guanylate cyclase, putative 0.0012 0.0046 0.0027
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0016 0.0092 0.0234
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0246 0.2925 0.2924
Leishmania major acetyl-CoA synthetase, putative 0.0014 0.0072 0.0172
Loa Loa (eye worm) thymidylate synthase 0.0113 0.1287 0.2644
Leishmania major S-adenosylhomocysteine hydrolase 0.027 0.3213 1
Brugia malayi AMP-binding enzyme family protein 0.0049 0.0497 0.1019
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0105 0.1187 0.3601
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0016 0.0092 0.0268
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0064 0.0685 0.1406
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0014 0.0072 0.0089
Plasmodium vivax adenosylhomocysteinase(S-adenosyl-L-homocystein e hydrolase), putative 0.027 0.3213 1
Trichomonas vaginalis conserved hypothetical protein 0.0054 0.0558 0.0952
Trichomonas vaginalis adenosylhomocysteinase, putative 0.027 0.3213 0.5757
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0016 0.0092 0.0234
Trichomonas vaginalis rotamase, putative 0.0033 0.0296 0.0478
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0012 0.0046 0.0091
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.0092 0.0234
Mycobacterium ulcerans acyl-CoA synthetase 0.0014 0.0072 0.0089
Echinococcus multilocularis expressed protein 0.0033 0.0296 0.0295
Echinococcus granulosus lipoxygenase domain containing protein 0.0021 0.015 0.038
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0016 0.0092 0.6175
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0016 0.0092 0.0284
Loa Loa (eye worm) adenosylhomocysteinase 0.027 0.3213 0.6597
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.011 0.125 0.3802
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0046 0.0462 0.1309
Loa Loa (eye worm) oxidoreductase 0.0014 0.0072 0.0148
Mycobacterium ulcerans thymidylate synthase 0.0113 0.1287 0.3709
Loa Loa (eye worm) hypothetical protein 0.0025 0.0201 0.0412
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0016 0.0092 0.0148
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.002 0.0138 0.035
Plasmodium vivax SET domain protein, putative 0.0058 0.0609 0.1722
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0117 0.1332 0.4057
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0011 0.0031 0.0045
Entamoeba histolytica phosphofructokinase, putative 0.011 0.125 0.383
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.003 0.0261 0.1465
Schistosoma mansoni acetyl-CoA synthetase 0.0014 0.0072 0.0222
Brugia malayi intermediate filament protein 0.0053 0.0553 0.1135
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0092 0.0234
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0014 0.0072 0.0071
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0092 0.0234
Brugia malayi thymidylate synthase 0.0113 0.1287 0.2643
Trichomonas vaginalis adenylate cyclase, type VII, putative 0.0012 0.0046 0.0027
Trichomonas vaginalis 6-phosphofructokinase, putative 0.003 0.0261 0.0416
Echinococcus granulosus tumor protein p63 0.0328 0.3924 1
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0016 0.0092 0.0235
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0014 0.0072 0.0089
Echinococcus multilocularis musashi 0.0053 0.0553 0.0553
Leishmania major 4-coumarate:coa ligase-like protein 0.0049 0.0497 0.15
Plasmodium falciparum thioredoxin reductase 0.0016 0.0092 0.0284
Trypanosoma cruzi trypanothione reductase, putative 0.0046 0.0462 0.1392
Entamoeba histolytica phosphofructokinase, putative 0.011 0.125 0.383
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0016 0.0092 0.0234
Trichomonas vaginalis antibiotic synthetase, putative 0.0014 0.0072 0.0073
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0049 0.0497 0.1422
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0037 0.0345 0.2353
Schistosoma mansoni 6-phosphofructokinase 0.011 0.125 0.389
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0016 0.0092 0.0359
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.002 0.0138 0.0378
Brugia malayi hypothetical protein 0.0158 0.1842 0.3781
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0092 0.0235
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0049 0.0497 0.1422
Trichomonas vaginalis bromodomain-containing protein, putative 0.0043 0.0427 0.0715
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.002 0.0138 0.0378
Brugia malayi dihydrofolate reductase family protein 0.0115 0.1314 0.2698
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.0229 0.2706 0.8424
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0035 0.032 0.0861
Loa Loa (eye worm) hypothetical protein 0.0052 0.0541 0.1111
Echinococcus multilocularis bloom syndrome protein 0.0021 0.015 0.0149
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0032 0.0286 0.0842
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0049 0.0497 0.1419
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0092 0.0092
Loa Loa (eye worm) RecQ helicase 0.0021 0.015 0.0308
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0058 0.0609 0.1894
Mycobacterium tuberculosis Probable thymidylate synthase ThyA (ts) (TSASE) 0.0113 0.1287 0.3917
Schistosoma mansoni ap endonuclease 0.002 0.0138 0.0428
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0105 0.1187 0.3601
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0014 0.0072 0.0077
Loa Loa (eye worm) hypothetical protein 0.0037 0.0345 0.0708
Trichomonas vaginalis phosphofructokinase, putative 0.011 0.125 0.2205
Mycobacterium leprae putative S-adenosyl-L-homocysteine hydrolase SahH 0.027 0.3213 1
Plasmodium falciparum glutathione reductase 0.0046 0.0462 0.1436
Onchocerca volvulus 0.0053 0.0553 0.092
Echinococcus granulosus expressed protein 0.0033 0.0296 0.0752
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0261 0.0416
Brugia malayi 6-phosphofructokinase 0.011 0.125 0.2566
Trichomonas vaginalis adenosylhomocysteinase, putative 0.027 0.3213 0.5757
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0016 0.0092 0.0286
Loa Loa (eye worm) hypothetical protein 0.0016 0.0098 0.0202
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0092 0.0092
Mycobacterium ulcerans ketopantoate reductase, ApbA 0.0285 0.34 1
Loa Loa (eye worm) hypothetical protein 0.0053 0.0553 0.1136
Loa Loa (eye worm) phosphofructokinase 0.011 0.125 0.2567
Schistosoma mansoni lipoxygenase 0.0124 0.1416 0.4407
Loa Loa (eye worm) hypothetical protein 0.0025 0.0201 0.0412
Mycobacterium leprae POSSIBLE O-SUCCINYLBENZOIC ACID--CoA LIGASE MENE (OSB-CoA SYNTHETASE) (O-SUCCINYLBENZOATE-CoA SYNTHASE) 0.0014 0.0072 0.0081
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.011 0.125 0.3858
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.0072 0.0077
Trypanosoma brucei S-adenosylhomocysteine hydrolase, putative 0.027 0.3213 1
Loa Loa (eye worm) acetyltransferase 0.0147 0.1702 0.3494
Trypanosoma brucei trypanothione reductase 0.0046 0.0462 0.1392
Mycobacterium ulcerans putative regulatory protein 0.0035 0.0325 0.0842
Brugia malayi Thioredoxin reductase 0.0046 0.0462 0.0947
Mycobacterium ulcerans S-adenosyl-L-homocysteine hydrolase 0.027 0.3213 0.9443
Plasmodium vivax multidomain scavenger receptor, putative 0.0021 0.015 0.0261
Brugia malayi Pre-SET motif family protein 0.0404 0.487 1
Chlamydia trachomatis dihydrofolate reductase 0.0115 0.1314 1
Toxoplasma gondii 6-phosphofructokinase 0.003 0.0261 0.0768
Echinococcus multilocularis Polycystic kidney disease protein 0.0021 0.015 0.0149
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.002 0.0138 1
Leishmania major trypanothione reductase 0.0046 0.0462 0.1392
Leishmania major ATP-dependent phosphofructokinase 0.011 0.125 0.3858
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0685 0.213
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0014 0.0072 0.0147
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.0072 0.0077
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0069 0.0747 0.1532
Brugia malayi Bloom's syndrome protein homolog 0.0021 0.015 0.0307
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0058 0.0609 0.179
Leishmania major 4-coumarate:coa ligase-like protein 0.0049 0.0497 0.15
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0009 0.0001 0.0001
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0037 0.0345 0.0939
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0138 0.0193
Schistosoma mansoni bifunctional dihydrofolate reductase-thymidylate synthase 0.0113 0.1287 0.4006
Schistosoma mansoni blooms syndrome DNA helicase 0.0016 0.0096 0.0298
Echinococcus granulosus single minded 2 0.0035 0.0325 0.0826
Echinococcus multilocularis adenosylhomocysteinase 0.027 0.3213 0.3212
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0092 0.0234
Brugia malayi Cytochrome P450 family protein 0.0012 0.0042 0.0086
Trichomonas vaginalis mercuric reductase, putative 0.0016 0.0092 0.0109
Entamoeba histolytica phosphofructokinase, putative 0.011 0.125 0.383
Trichomonas vaginalis glutathione reductase, putative 0.0016 0.0092 0.0109
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.002 0.0138 0.0137
Echinococcus granulosus Aryl hydrocarbon receptor nuclear 0.0012 0.0046 0.0117
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0016 0.0092 0.0077
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0035 0.032 0.0861
Plasmodium falciparum glutathione reductase 0.0016 0.0092 0.0284
Trichomonas vaginalis DNA helicase recq, putative 0.0021 0.015 0.0214
Leishmania major acetyl-CoA synthetase, putative 0.0014 0.0072 0.0172
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.002 0.0138 0.0378
Mycobacterium leprae PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) 0.0113 0.1287 0.392
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0016 0.0092 0.0284
Brugia malayi isocitrate dehydrogenase 0.0016 0.0092 0.0189
Echinococcus multilocularis Aryl hydrocarbon receptor nuclear 0.0012 0.0046 0.0046
Toxoplasma gondii peptidylprolyl isomerase 0.0032 0.0286 0.084
Plasmodium vivax acyl-CoA synthetase, putative 0.0037 0.0345 0.0881
Onchocerca volvulus 0.0049 0.0497 0.0817
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0105 0.1187 0.3601
Schistosoma mansoni lipoxygenase 0.0086 0.0959 0.2982
Loa Loa (eye worm) hypothetical protein 0.0026 0.0213 0.0437
Trichomonas vaginalis adenosylhomocysteinase, putative 0.0085 0.0937 0.1638
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0117 0.1332 0.4057
Schistosoma mansoni polycystin 1-related 0.0021 0.015 0.0464
Echinococcus multilocularis lipoxygenase domain containing protein 0.0021 0.015 0.0149
Echinococcus multilocularis 6 phosphofructokinase 0.011 0.125 0.1249
Brugia malayi phosphofructokinase 0.011 0.125 0.2566
Loa Loa (eye worm) 6-phosphofructokinase 0.011 0.125 0.2567
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0014 0.0072 0.0148
Schistosoma mansoni rab6-interacting 0.0021 0.015 0.0464
Onchocerca volvulus 0.0014 0.0072 0.0047
Trichomonas vaginalis conserved hypothetical protein 0.0285 0.34 0.6095
Leishmania major protein kinase, putative 0.0012 0.0046 0.0091
Leishmania major cytochrome p450-like protein 0.0012 0.0042 0.0078
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.0092 0.0234
Mycobacterium tuberculosis Hypothetical protein 0.0054 0.0558 0.1612
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0296 0.0478
Brugia malayi exodeoxyribonuclease III family protein 0.002 0.0138 0.0282
Loa Loa (eye worm) dihydrofolate reductase 0.0115 0.1314 0.2699
Loa Loa (eye worm) hypothetical protein 0.0037 0.0345 0.0708
Loa Loa (eye worm) hypothetical protein 0.0058 0.0609 0.1251
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0016 0.0092 0.0092
Brugia malayi AMP-binding enzyme family protein 0.0014 0.0072 0.0147
Schistosoma mansoni rab6-interacting 0.0021 0.015 0.0464
Loa Loa (eye worm) hypothetical protein 0.0037 0.0345 0.0708
Mycobacterium ulcerans dihydrofolate reductase DfrA 0.0115 0.1314 0.3789
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0014 0.0072 0.0172
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0014 0.0072 0.0172
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0032 0.0286 0.0842
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0026 0.0213 0.0212
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0138 0.0224
Schistosoma mansoni adenosylhomocysteinase 0.027 0.3213 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0014 0.0072 0.0089
Mycobacterium ulcerans acyl-CoA synthetase 0.0049 0.0497 0.1354
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0012 0.0046 0.0027
Echinococcus multilocularis tar DNA binding protein 0.0064 0.0685 0.0684
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0032 0.0286 0.0801
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.0229 0.2706 0.796
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0049 0.0497 0.1354
Schistosoma mansoni loxhd1 0.0021 0.015 0.0464
Plasmodium vivax thioredoxin reductase, putative 0.0046 0.0462 0.1254
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0016 0.0092 0.0234
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0246 0.2925 0.7452
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0014 0.0066 0.0191
Mycobacterium tuberculosis Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) 0.0115 0.1314 0.4003
Loa Loa (eye worm) hypothetical protein 0.0014 0.0072 0.0148
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0043 0.0427 0.1142
Trichomonas vaginalis hypothetical protein 0.0064 0.0678 0.117
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.011 0.125 1
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0043 0.0427 0.0715
Schistosoma mansoni 6-phosphofructokinase 0.011 0.125 0.389
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0124 0.1416 0.1416
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0014 0.0072 0.0127
Schistosoma mansoni rotamase 0.0033 0.0296 0.0918
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0014 0.0072 0.0089
Mycobacterium ulcerans 2-dehydropantoate 2-reductase 0.011 0.1252 0.3602
Echinococcus granulosus intermediate filament protein 0.0053 0.0553 0.1408
Schistosoma mansoni aryl hydrocarbon receptor 0.0047 0.0476 0.1479
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0014 0.0072 0.021
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.0229 0.2706 0.8415
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0685 0.213
Echinococcus granulosus Polycystic kidney disease protein 0.0021 0.015 0.038
Schistosoma mansoni intermediate filament proteins 0.0053 0.0553 0.172
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0.0092 0.019
Schistosoma mansoni lamin 0.0053 0.0553 0.172
Schistosoma mansoni cellular tumor antigen P53 0.0048 0.0485 0.1509
Schistosoma mansoni hypothetical protein 0.0021 0.015 0.0464
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0014 0.0072 0.0077
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0685 0.213
Onchocerca volvulus 0.0014 0.0072 0.0047
Schistosoma mansoni single-minded 0.0047 0.0476 0.1479
Onchocerca volvulus 0.0035 0.0325 0.0505
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0058 0.0609 0.1894
Plasmodium falciparum adenosylhomocysteinase 0.027 0.3213 1
Trichomonas vaginalis rotamase, putative 0.0032 0.0286 0.0461
Mycobacterium tuberculosis Conserved hypothetical protein 0.011 0.1252 0.3804
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0012 0.0046 0.0091
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.003 0.0261 0.1697
Loa Loa (eye worm) hypothetical protein 0.0021 0.015 0.0307
Echinococcus granulosus RUN 0.0021 0.015 0.038
Onchocerca volvulus 0.0014 0.0072 0.0047
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0092 0.0234
Echinococcus multilocularis lamin 0.0053 0.0553 0.0553
Echinococcus granulosus lipoxygenase domain containing protein 0.0021 0.015 0.038
Trypanosoma cruzi trypanothione reductase, putative 0.0016 0.0092 0.0234
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0058 0.0609 0.0608
Loa Loa (eye worm) hypoxia-induced factor 1 0.0146 0.1691 0.3472
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0016 0.0092 0.0232
Loa Loa (eye worm) hypothetical protein 0.0037 0.0345 0.0708
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0138 0.0428
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0033 0.0296 0.0607
Echinococcus granulosus histone acetyltransferase KAT2B 0.0143 0.1651 0.4206
Loa Loa (eye worm) thioredoxin reductase 0.0046 0.0462 0.0948
Brugia malayi Dihydrofolate reductase 0.0115 0.1314 0.2698
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0069 0.0747 0.2248
Trichomonas vaginalis phosphofructokinase, putative 0.011 0.125 0.2205
Entamoeba histolytica acyl-CoA synthetase, putative 0.0049 0.0497 0.1462
Onchocerca volvulus 0.0058 0.0609 0.1021
Toxoplasma gondii phosphofructokinase PFKII 0.003 0.0261 0.0768
Leishmania major dihydrofolate reductase-thymidylate synthase 0.0229 0.2706 0.8415
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0016 0.0092 0.0091
Trichomonas vaginalis antibiotic synthetase, putative 0.0014 0.0072 0.0073
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0014 0.0072 0.0172
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0014 0.0072 0.0089
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0012 0.0046 0.0095
Giardia lamblia Histone acetyltransferase GCN5 0.004 0.0382 1
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0016 0.0092 0.0077
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0016 0.0092 0.014
Brugia malayi bHLH-PAS transcription factor 0.0035 0.0325 0.0666
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0014 0.0072 0.0222
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0014 0.0072 0.0172
Echinococcus granulosus histone acetyltransferase KAT2B 0.0043 0.0427 0.1086
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0016 0.0092 0.6175
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0069 0.0747 0.2283
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0046 0.0027
Echinococcus granulosus thymidylate synthase 0.0113 0.1287 0.328
Echinococcus multilocularis thymidylate synthase 0.0113 0.1287 0.1287
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0011 0.0031 0.0045
Mycobacterium ulcerans acyl-CoA synthetase 0.0014 0.0072 0.0089
Echinococcus granulosus aryl hydrocarbon receptor 0.0012 0.0046 0.0117
Trichomonas vaginalis set domain proteins, putative 0.046 0.5557 1
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0029 0.0248 0.0509
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0246 0.2925 0.9104
Entamoeba histolytica acetyltransferase, GNAT family 0.004 0.0382 0.1103
Loa Loa (eye worm) hypothetical protein 0.0049 0.0497 0.102
Mycobacterium ulcerans acyl-CoA synthetase 0.0014 0.0072 0.0089
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.003 0.0261 0.1697
Brugia malayi AMP-binding enzyme family protein 0.0049 0.0497 0.1019
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.003 0.0261 0.0812
Echinococcus multilocularis lipoxygenase domain containing protein 0.0021 0.015 0.0149
Toxoplasma gondii thioredoxin reductase 0.0046 0.0462 0.1357
Brugia malayi glutathione reductase 0.0046 0.0462 0.0947
Brugia malayi Adenosylhomocysteinase 0.027 0.3213 0.6597
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.002 0.0138 0.0378
Schistosoma mansoni ap endonuclease 0.002 0.0138 0.0428
Loa Loa (eye worm) cytochrome P450 family protein 0.0012 0.0042 0.0087
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0014 0.0072 0.0089
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0014 0.0072 0.0172
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0147 0.1702 0.5296
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0016 0.0092 0.0284
Mycobacterium ulcerans acyl-CoA synthetase 0.0014 0.0072 0.0089
Toxoplasma gondii exonuclease III APE 0.002 0.0138 0.0404
Brugia malayi PAS domain containing protein 0.0047 0.0476 0.0976
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.003 0.0261 0.0723
Echinococcus multilocularis aryl hydrocarbon receptor 0.0012 0.0046 0.0046
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0014 0.0072 0.0077
Echinococcus granulosus tar DNA binding protein 0.0064 0.0685 0.1744
Mycobacterium tuberculosis Probable adenosylhomocysteinase SahH (S-adenosyl-L-homocysteine hydrolase) (adohcyase) 0.027 0.3213 1
Plasmodium vivax glutathione reductase, putative 0.0046 0.0462 0.1254

Activities

Activity type Activity value Assay description Source Reference
ED50 (functional) = 16.2 ug ml-1 Cytotoxicity against human MCF7 cells after 3 days by SRB assay ChEMBL. 14640511
ED50 (functional) > 20 ug ml-1 Cytotoxicity against human A549 cells after 3 days by SRB assay ChEMBL. 14640511
ED50 (functional) > 20 ug ml-1 Cytotoxicity against human KB cells after 3 days by SRB assay ChEMBL. 14640511
ED50 (functional) > 20 ug ml-1 Cytotoxicity against human PC3 cells after 3 days by SRB assay ChEMBL. 14640511
ED50 (functional) > 20 ug ml-1 Cytotoxicity against human 1A9 cells after 3 days by SRB assay ChEMBL. 14640511
ED50 (functional) > 20 ug ml-1 Cytotoxicity against human 1A9/PTX10 cells after 3 days by SRB assay ChEMBL. 14640511
ED50 (functional) > 20 ug ml-1 Cytotoxicity against human 1A9 cells after 6 days by SRB assay ChEMBL. 14640511
ED50 (functional) > 20 ug ml-1 Cytotoxicity against human 1A9/PTX10 cells after 6 days by SRB assay ChEMBL. 14640511
MIC (functional) > 25 ug ml-1 Antimycobacterial activity against Mycobacterium tuberculosis isolate 02TBDM039EP097 after 24 hrs by tetrazolium microplate assay ChEMBL. 21419633

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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