Detailed information for compound 978174

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 287.314 | Formula: C15H17N3O3
  • H donors: 3 H acceptors: 2 LogP: 3.07 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: COC(=O)c1cc([nH]c1NNC(=O)CC)c1ccccc1
  • InChi: 1S/C15H17N3O3/c1-3-13(19)17-18-14-11(15(20)21-2)9-12(16-14)10-7-5-4-6-8-10/h4-9,16,18H,3H2,1-2H3,(H,17,19)
  • InChiKey: XFCXENNZYYFPEW-UHFFFAOYSA-N  


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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni hypothetical protein 0.0008 0.0003 0.0003
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0008 0.0007 0.0004
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0041 0.0529 0.7983
Echinococcus multilocularis thyroid hormone receptor alpha 0.0008 0.0007 0.0007
Brugia malayi hypothetical protein 0.0035 0.0429 0.0806
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0008 0.0007 0.0007
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0008 0.0007 0.0007
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0008 0.0007 0.0007
Loa Loa (eye worm) histone methyltransferase 0.001 0.003 0.0026
Entamoeba histolytica hypothetical protein 0.0049 0.0648 1
Echinococcus multilocularis sodium:glucose cotransporter 2 0.0038 0.0476 0.0476
Brugia malayi ecdysteroid receptor 0.0008 0.0007 0.0007
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0041 0.0529 1
Leishmania major importin beta-1 subunit, putative 0.0049 0.0648 1
Trichomonas vaginalis dynamin, putative 0.0023 0.024 0.3079
Onchocerca volvulus 0.0035 0.0429 0.1289
Loa Loa (eye worm) hypothetical protein 0.0035 0.0429 0.0426
Echinococcus granulosus sodium and chloride dependent glycine 0.0035 0.0429 0.0429
Brugia malayi hypothetical protein 0.0028 0.0322 0.0603
Plasmodium vivax amine transporter, putative 0.0035 0.0429 0.4828
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0044 0.0577 0.6744
Schistosoma mansoni sodium-dependent amino acid transporter 0.0035 0.0429 0.0429
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0008 0.0007 0.0007
Schistosoma mansoni dynamin 0.0025 0.0267 0.0267
Loa Loa (eye worm) hypothetical protein 0.006 0.0827 0.0824
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0035 0.0429 0.0429
Schistosoma mansoni hypothetical protein 0.0032 0.0387 0.0387
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0008 0.0007 0.0007
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0044 0.0577 0.6961
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0035 0.0429 0.0806
Echinococcus granulosus importin subunit beta 1 0.006 0.0827 0.0827
Loa Loa (eye worm) kap beta 3 protein 0.0011 0.0058 0.0055
Leishmania major hypothetical protein, conserved 0.0028 0.0322 0.4951
Schistosoma mansoni dynamin 0.0025 0.0267 0.0267
Onchocerca volvulus 0.0038 0.0476 0.143
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0008 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0035 0.0429 0.0426
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0232 0.3514 0.3514
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0232 0.3514 0.3514
Toxoplasma gondii dynamin-related protein DRPB 0.0023 0.024 0.2869
Onchocerca volvulus 0.0031 0.0367 0.1098
Trichomonas vaginalis dynamin, putative 0.0023 0.024 0.3079
Trichomonas vaginalis dynamin, putative 0.0023 0.024 0.3079
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.0035 0.0429 0.5
Trypanosoma cruzi dynamin-1-like protein 0.0023 0.024 0.3667
Loa Loa (eye worm) hypothetical protein 0.0232 0.3514 0.3512
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0041 0.0529 0.6379
Trypanosoma cruzi PAB1-binding protein , putative 0.0028 0.0322 0.4951
Schistosoma mansoni hypothetical protein 0.0032 0.0387 0.0387
Brugia malayi Dynamin 0.0025 0.0267 0.05
Echinococcus multilocularis 0.0008 0.0003 0.0003
Brugia malayi Dynamin central region family protein 0.0023 0.024 0.0447
Echinococcus granulosus sodium coupled monocarboxylate transporter 1 0.0038 0.0476 0.0476
Loa Loa (eye worm) hypothetical protein 0.0008 0.0007 0.0004
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0044 0.0577 1
Echinococcus granulosus GPCR family 2 0.0032 0.0387 0.0387
Loa Loa (eye worm) hypothetical protein 0.0035 0.0429 0.0426
Loa Loa (eye worm) hypothetical protein 0.0038 0.0476 0.0472
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0232 0.3514 0.3514
Toxoplasma gondii HEAT repeat-containing protein 0.006 0.0827 1
Brugia malayi vesicular acetylcholine transporter unc-17 0.0217 0.3283 0.6204
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0008 0.0007 0.0007
Trichomonas vaginalis interferon-induced GTP-binding protein mx, putative 0.0023 0.024 0.3079
Echinococcus multilocularis cpg binding protein 0.0033 0.0394 0.0394
Loa Loa (eye worm) hypothetical protein 0.0008 0.0007 0.0004
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0013 0.0078 0.0078
Loa Loa (eye worm) hypothetical protein 0.0157 0.2347 0.2345
Schistosoma mansoni hypothetical protein 0.0528 0.8162 0.8162
Trypanosoma cruzi PAB1-binding protein , putative 0.0028 0.0322 0.4951
Echinococcus granulosus solute carrier family 5 0.0038 0.0476 0.0476
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0102 0.1485 0.1483
Brugia malayi Nuclear hormone receptor-like 1 0.0008 0.0007 0.0007
Toxoplasma gondii histone lysine methyltransferase SET1 0.0059 0.0803 0.9711
Entamoeba histolytica dynamin-like protein 0.0023 0.024 0.3079
Echinococcus granulosus serotonin transporter 0.0035 0.0429 0.0429
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0008 0.0007 0.0007
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0008 0.0007 0.0007
Plasmodium falciparum amino acid transporter, putative 0.0035 0.0429 0.4828
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0008 0.0007 0.0007
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0035 0.0429 0.0426
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0008 0.0007 0.0004
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0044 0.0577 0.6961
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0066 0.0914 0.0914
Echinococcus granulosus GTP binding nuclear protein Ran 0.0044 0.0577 0.0577
Toxoplasma gondii transporter, solute:sodium symporter (SSS) family protein 0.0038 0.0476 0.5733
Brugia malayi hypothetical protein 0.0157 0.2347 0.4434
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0035 0.0429 0.5172
Echinococcus granulosus cpg binding protein 0.0033 0.0394 0.0394
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0035 0.0429 0.0429
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0008 0.0007 0.0007
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0041 0.0529 0.8154
Loa Loa (eye worm) hypothetical protein 0.0032 0.0387 0.0384
Schistosoma mansoni sodium/chloride dependent transporter 0.0035 0.0429 0.0429
Brugia malayi Importin beta-1 subunit 0.006 0.0827 0.1558
Schistosoma mansoni steroid hormone receptor ad4bp 0.0008 0.0007 0.0007
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0013 0.0078 0.0078
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0429 0.4828
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.0035 0.0429 0.0429
Echinococcus multilocularis sodium coupled monocarboxylate transporter 1 0.0038 0.0476 0.0476
Brugia malayi nuclear hormone receptor 0.0008 0.0007 0.0007
Leishmania major GTP-binding protein, putative 0.0044 0.0577 0.8898
Echinococcus granulosus sodium:glucose cotransporter 0.0038 0.0476 0.0476
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.0232 0.3514 0.3514
Schistosoma mansoni hypothetical protein 0.0032 0.0387 0.0387
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0035 0.0429 0.0429
Echinococcus multilocularis dynamin 1 0.0025 0.0267 0.0267
Schistosoma mansoni ran 0.0044 0.0577 0.0577
Trypanosoma brucei dynamin-1-like protein 0.0023 0.024 0.2869
Loa Loa (eye worm) norepinephrine transporter 0.0035 0.0429 0.0426
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0041 0.0529 0.6379
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0032 0.0387 0.0387
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0018 0.0168 0.2561
Loa Loa (eye worm) hypothetical protein 0.0008 0.0007 0.0004
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0035 0.0429 0.0429
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0008 0.0007 0.0004
Schistosoma mansoni ran 0.0044 0.0577 0.0577
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0168 0.0312
Entamoeba histolytica Ran family GTPase 0.0044 0.0577 0.8795
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0008 0.0007 0.0004
Onchocerca volvulus 0.0035 0.0429 0.1289
Echinococcus granulosus transportin 1 0.0011 0.0058 0.0058
Trypanosoma brucei PAB1-binding protein , putative 0.0028 0.0322 0.3873
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.0035 0.0429 0.0429
Trypanosoma cruzi importin beta-1 subunit, putative 0.0049 0.0648 1
Echinococcus multilocularis solute carrier family 5 0.0038 0.0476 0.0476
Echinococcus granulosus cytochrome P450 2K1 0.0008 0.0003 0.0003
Trypanosoma brucei dynamin-1-like protein 0.0023 0.024 0.2869
Echinococcus multilocularis GPCR, family 2 0.0032 0.0387 0.0387
Echinococcus multilocularis importin subunit beta 1 0.006 0.0827 0.0827
Plasmodium vivax ataxin-2 like protein, putative 0.0028 0.0322 0.3436
Brugia malayi nuclear receptor NHR-88 0.0008 0.0007 0.0007
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0008 0.0007 0.0007
Schistosoma mansoni cpg binding protein 0.0031 0.0367 0.0367
Echinococcus multilocularis dynamin 0.0023 0.024 0.024
Toxoplasma gondii exonuclease III APE 0.0018 0.0168 0.2004
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0044 0.0577 0.1085
Schistosoma mansoni nuclear hormone receptor 0.0008 0.0007 0.0007
Echinococcus multilocularis translational activator gcn1 0.0011 0.0058 0.0058
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0645 1 1
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0035 0.0429 0.0429
Plasmodium falciparum ataxin-2 like protein, putative 0.0028 0.0322 0.3436
Echinococcus multilocularis vesicular acetylcholine transporter 0.0217 0.3283 0.3283
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0008 0.0007 0.0004
Loa Loa (eye worm) vesicular acetylcholine transporter unc-17 0.0217 0.3283 0.328
Plasmodium vivax importin-beta 2, putative 0.006 0.0827 1
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0041 0.0529 1
Toxoplasma gondii hypothetical protein 0.0035 0.0429 0.5172
Echinococcus granulosus inositol monophosphatase 1 0.0041 0.0529 0.0529
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0008 0.0007 0.0007
Echinococcus multilocularis ecdysone induced protein 78C 0.0008 0.0007 0.0007
Echinococcus granulosus sodium:myo inositol cotransporter 0.0038 0.0476 0.0476
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0168 0.0165
Schistosoma mansoni hypothetical protein 0.0013 0.0078 0.0078
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0008 0.0007 0.0007
Echinococcus granulosus FTZ F1 alpha 0.0008 0.0007 0.0007
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0168 0.1434
Treponema pallidum sodium- and chloride- dependent transporter 0.0035 0.0429 1
Schistosoma mansoni RAR-like nuclear receptor 0.0008 0.0007 0.0007
Brugia malayi photoreceptor-specific nuclear receptor 0.0008 0.0007 0.0007
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0041 0.0529 0.8154
Trichomonas vaginalis dynamin, putative 0.0023 0.024 0.3079
Echinococcus multilocularis sodium and chloride dependent glycine 0.0035 0.0429 0.0429
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0168 0.187
Schistosoma mansoni hypothetical protein 0.0528 0.8162 0.8162
Brugia malayi Latrophilin receptor protein 2 0.0032 0.0387 0.0726
Schistosoma mansoni ap endonuclease 0.0018 0.0168 0.0168
Brugia malayi Steroid receptor seven-up type 2 0.0008 0.0007 0.0007
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0168 0.187
Schistosoma mansoni dynamin 0.0023 0.024 0.024
Echinococcus multilocularis high affinity choline transporter 1 0.0345 0.5289 0.5289
Echinococcus granulosus translational activator gcn1 0.0011 0.0058 0.0058
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0102 0.1485 0.2804
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0008 0.0007 0.0004
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0008 0.0007 0.0007
Brugia malayi kap beta 3 protein 0.0011 0.0058 0.0104
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0008 0.0007 0.0007
Echinococcus multilocularis dynamin 1 protein 0.0023 0.024 0.024
Echinococcus granulosus geminin 0.0528 0.8162 0.8162
Echinococcus granulosus dynamin 1 0.0025 0.0267 0.0267
Schistosoma mansoni high-affinity choline transporter 0.0345 0.5289 0.5289
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0044 0.0577 0.8898
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0018 0.0168 0.2004
Schistosoma mansoni thyroid hormone receptor 0.0008 0.0007 0.0007
Brugia malayi latrophilin 2 splice variant baaae 0.007 0.0977 0.1842
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0049 0.0648 1
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0044 0.0577 0.8898
Schistosoma mansoni sodium/chloride dependent transporter 0.0035 0.0429 0.0429
Schistosoma mansoni retinoic acid receptor RXR 0.0008 0.0007 0.0007
Schistosoma mansoni cytochrome P450 0.0008 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0008 0.0007 0.0004
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0008 0.0007 0.0007
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0008 0.0007 0.0007
Schistosoma mansoni importin beta-1 0.006 0.0827 0.0827
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0018 0.0168 0.187
Echinococcus multilocularis sodium:myo inositol cotransporter 0.0038 0.0476 0.0476
Toxoplasma gondii HEAT repeat-containing protein 0.0011 0.0058 0.0665
Schistosoma mansoni vesicular acetylcholine transporter 0.0217 0.3283 0.3283
Brugia malayi Sodium:solute symporter family protein 0.0038 0.0476 0.0893
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0008 0.0007 0.0007
Echinococcus multilocularis geminin 0.0528 0.8162 0.8162
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0037 0.0461 1
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0008 0.0007 0.0007
Plasmodium falciparum importin beta, putative 0.006 0.0827 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0008 0.0007 0.0004
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.0035 0.0429 0.0806
Echinococcus multilocularis FTZ F1 alpha 0.0008 0.0007 0.0007
Brugia malayi RNA, U transporter 1 0.0172 0.2575 0.4865
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0044 0.0577 0.0573
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0018 0.0168 0.3141
Schistosoma mansoni coup transcription factor 0.0008 0.0007 0.0007
Onchocerca volvulus Vesicular acetylcholine transporter homolog 0.0217 0.3283 1
Echinococcus granulosus dynamin 0.0023 0.024 0.024
Echinococcus granulosus dynamin 1 protein 0.0023 0.024 0.024
Trichomonas vaginalis mgm1, putative 0.0023 0.024 0.3079
Loa Loa (eye worm) hypothetical protein 0.0008 0.0007 0.0004
Loa Loa (eye worm) hypothetical protein 0.0102 0.1485 0.1483
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0168 0.0168
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0018 0.0168 0.2561
Brugia malayi Inositol-1 0.0041 0.0529 0.0994
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0041 0.0529 0.7983
Trichomonas vaginalis dynamin, putative 0.0023 0.024 0.3079
Loa Loa (eye worm) hypothetical protein 0.0028 0.0322 0.0319
Loa Loa (eye worm) importin-beta domain-containing protein 0.0011 0.0058 0.0055
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0008 0.0007 0.0007
Plasmodium falciparum ataxin-2 like protein, putative 0.0028 0.0322 0.3436
Loa Loa (eye worm) hypothetical protein 0.0232 0.3514 0.3512
Schistosoma mansoni thyroid hormone receptor 0.0008 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0035 0.0429 0.0426
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0032 0.0387 0.0726
Loa Loa (eye worm) steroid hormone receptor 0.0008 0.0007 0.0004
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0035 0.0429 0.0806
Loa Loa (eye worm) solute carrier family 6 member 4 0.0035 0.0429 0.0426
Echinococcus multilocularis serotonin transporter 0.0035 0.0429 0.0429
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0041 0.0529 0.7983
Echinococcus multilocularis snurportin 1 0.0645 1 1
Loa Loa (eye worm) DRP-1 protein 0.0023 0.024 0.0236
Toxoplasma gondii HEAT repeat-containing protein 0.0011 0.0058 0.0665
Loa Loa (eye worm) inositol-1 0.0041 0.0529 0.0526
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0018 0.0168 0.3609
Leishmania major hypothetical protein, conserved 0.0011 0.0058 0.085
Schistosoma mansoni hypothetical protein 0.0032 0.0387 0.0387
Schistosoma mansoni importin-beta 2 0.0011 0.0058 0.0058
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0008 0.0007 0.0007
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0008 0.0007 0.0007
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0035 0.0429 0.0426
Trypanosoma brucei Importin-beta N-terminal domain/HEAT-like repeat, putative 0.0011 0.0058 0.0665
Leishmania major GTP-binding protein, putative 0.0023 0.024 0.3667
Loa Loa (eye worm) latrophilin receptor protein 2 0.0032 0.0387 0.0384
Giardia lamblia Dynamin 0.0023 0.024 0.1745
Loa Loa (eye worm) CXXC zinc finger family protein 0.0031 0.0367 0.0363
Echinococcus granulosus importin 5 0.0011 0.0058 0.0058
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0008 0.0007 0.0007
Echinococcus multilocularis sodium and chloride dependent glycine 0.0035 0.0429 0.0429
Schistosoma mansoni sodium/chloride dependent transporter 0.0035 0.0429 0.0429
Trichomonas vaginalis dynamin, putative 0.0023 0.024 0.3079
Echinococcus granulosus ecdysone induced protein 78C 0.0008 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0345 0.5289 0.5287
Toxoplasma gondii hypothetical protein 0.0035 0.0429 0.5172
Trichomonas vaginalis importin beta-1, putative 0.0049 0.0648 1
Trypanosoma brucei ULK family serine/threonine-protein kinase, putative 0.0011 0.0058 0.0665
Toxoplasma gondii dynamin-related protein DRPA 0.0023 0.024 0.2869
Onchocerca volvulus 0.0157 0.2347 0.7144
Loa Loa (eye worm) hypothetical protein 0.0025 0.0267 0.0264
Loa Loa (eye worm) hypothetical protein 0.0008 0.0007 0.0004
Loa Loa (eye worm) hypothetical protein 0.0008 0.0007 0.0004
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0049 0.0648 1
Schistosoma mansoni inositol monophosphatase 0.0041 0.0529 0.0529
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0032 0.0387 0.0387
Echinococcus multilocularis inositol monophosphatase 1 0.0041 0.0529 0.0529
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0168 0.1434
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0018 0.0168 0.2561
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0035 0.0429 0.5172
Loa Loa (eye worm) hypothetical protein 0.007 0.0977 0.0974
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0008 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0035 0.0429 0.0426
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0008 0.0007 0.0007
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0008 0.0007 0.0007
Echinococcus granulosus sodium:glucose cotransporter 2 0.0038 0.0476 0.0476
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.0028 0.0046
Loa Loa (eye worm) hypothetical protein 0.0035 0.0429 0.0426
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0168 0.0168
Loa Loa (eye worm) hypothetical protein 0.0008 0.0007 0.0004
Echinococcus multilocularis transportin 1 0.0011 0.0058 0.0058
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0008 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0035 0.0429 0.0426
Schistosoma mansoni cpg binding protein 0.0033 0.0394 0.0394
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0035 0.0429 0.0429
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0008 0.0007 0.0007
Schistosoma mansoni sodium/solute symporter 0.0038 0.0476 0.0476
Loa Loa (eye worm) serotonin transporter b 0.0035 0.0429 0.0426
Brugia malayi hypothetical protein 0.0018 0.0165 0.0306
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0032 0.0387 0.0387
Echinococcus granulosus sodium and chloride dependent glycine 0.0035 0.0429 0.0429
Brugia malayi CXXC zinc finger family protein 0.0031 0.0367 0.0687
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0035 0.0429 0.0806
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.003 0.003
Brugia malayi GH02984p 0.0345 0.5289 1
Plasmodium falciparum dynamin-like protein 0.0023 0.024 0.2361
Trypanosoma brucei importin beta-1 subunit, putative 0.006 0.0827 1
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0035 0.0429 0.0429
Onchocerca volvulus 0.0035 0.0429 0.1289
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0008 0.0007 0.0007
Plasmodium vivax dynamin-like protein, putative 0.0023 0.024 0.2361
Brugia malayi steroid hormone receptor 0.0008 0.0007 0.0007
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0041 0.0529 0.8154
Schistosoma mansoni hypothetical protein 0.0645 1 1
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0044 0.0577 0.6744
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0032 0.0387 0.0387
Schistosoma mansoni ap endonuclease 0.0018 0.0168 0.0168
Trypanosoma brucei importin beta-1 subunit, putative 0.006 0.0827 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0429 0.0426
Schistosoma mansoni hypothetical protein 0.007 0.0977 0.0977
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0008 0.0007 0.0007
Schistosoma mansoni cpg binding protein 0.0033 0.0394 0.0394
Trichomonas vaginalis ran, putative 0.0044 0.0577 0.8795
Schistosoma mansoni inositol monophosphatase 0.0041 0.0529 0.0529
Schistosoma mansoni inositol transporter 0.0038 0.0476 0.0476
Echinococcus granulosus vesicular acetylcholine transporter 0.0217 0.3283 0.3283
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0035 0.0429 0.5172
Plasmodium falciparum transporter, putative 0.0035 0.0429 0.4828
Entamoeba histolytica dynamin-1-like protein, putative 0.0023 0.024 0.3079
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.0035 0.0429 0.0429
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0008 0.0007 0.0007
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0037 0.0461 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0102 0.1485 0.2804
Toxoplasma gondii dynamin gtpase 0.0015 0.0117 0.1374
Echinococcus multilocularis importin 5 0.0011 0.0058 0.0058
Echinococcus granulosus high affinity choline transporter 1 0.0345 0.5289 0.5289
Onchocerca volvulus 0.0035 0.0429 0.1289
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.0232 0.3514 0.3514
Plasmodium falciparum dynamin-like protein 0.0023 0.024 0.2361
Schistosoma mansoni inositol transporter 0.0038 0.0476 0.0476
Brugia malayi Dynamin 0.0025 0.0267 0.05
Toxoplasma gondii LsmAD domain-containing protein 0.0028 0.0322 0.3873
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0044 0.0577 0.0577
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.003 0.003
Trichomonas vaginalis inositol monophosphatase, putative 0.0041 0.0529 0.7983
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0035 0.0429 0.0429
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0035 0.0429 0.0806
Plasmodium vivax dynamin protein, putative 0.0023 0.024 0.2361

Activities

Activity type Activity value Assay description Source Reference
MFC (functional) = 6.25 ug ml-1 Antimicrobial activity against Candida albicans ATCC 10231 after 72 hrs by broth microdilution method ChEMBL. 18809229
MIC (functional) = 3.12 ug ml-1 Antimicrobial activity against Candida albicans ATCC 10231 by broth microdilution method ChEMBL. 18809229

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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