TDR Targets

Basic information

Technical information

TDR Targets ID: 979258
Name: 4-[(4-methyl-1H-indol-5-yl)amino]-2-[(E)-3-ox o-3-pyrrolidin-1-ylprop-1-enyl]thieno[3,2-e]p yridine-5-carbonitrile
MW: 427.521 | Formula: C24H21N5OS
H donors: 2 H acceptors: 3 LogP: 4.92 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: N#Cc1cnc2c(c1Nc1ccc3c(c1C)cc[nH]3)cc(s2)/C=C/C(=O)N1CCCC1
InChi: 1S/C24H21N5OS/c1-15-18-8-9-26-21(18)6-5-20(15)28-23-16(13-25)14-27-24-19(23)12-17(31-24)4-7-22(30)29-10-2-3-11-29/h4-9,12,14,26H,2-3,10-11H2,1H3,(H,27,28)/b7-4+
InChiKey: CRPUDAVZTZIKMJ-QPJJXVBHSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

4-[(4-methyl-1H-indol-5-yl)amino]-2-[(E)-3-oxo-3-pyrrolidin-1-yl-prop-1-enyl]thieno[3,2-e]pyridine-5-carbonitrile
4-[(4-methyl-1H-indol-5-yl)amino]-2-[(E)-3-oxo-3-1-pyrrolidinylprop-1-enyl]-5-thieno[3,2-e]pyridinecarbonitrile
2-[(E)-3-keto-3-pyrrolidin-1-yl-prop-1-enyl]-4-[(4-methyl-1H-indol-5-yl)amino]thieno[3,2-e]pyridine-5-carbonitrile

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	FYN proto-oncogene, Src family tyrosine kinase	Starlite/ChEMBL	References
Homo sapiens	SRC proto-oncogene, non-receptor tyrosine kinase	Starlite/ChEMBL	References
Homo sapiens	protein kinase C, epsilon	Starlite/ChEMBL	References
Homo sapiens	HCK proto-oncogene, Src family tyrosine kinase	Starlite/ChEMBL	References
Homo sapiens	LYN proto-oncogene, Src family tyrosine kinase	Starlite/ChEMBL	References
Homo sapiens	protein kinase C, delta	Starlite/ChEMBL	References
Homo sapiens	LCK proto-oncogene, Src family tyrosine kinase	Starlite/ChEMBL	References
Homo sapiens	protein kinase C, theta	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus granulosus	serine:threonine protein kinase N2	Get druggable targets OG5_129314	All targets in OG5_129314
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	Get druggable targets OG5_127750	All targets in OG5_127750
Loa Loa (eye worm)	TK protein kinase	Get druggable targets OG5_127750	All targets in OG5_127750
Onchocerca volvulus		Get druggable targets OG5_132502	All targets in OG5_132502
Echinococcus multilocularis	tyrosine protein kinase Srms	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma mansoni	serine/threonine protein kinase	Get druggable targets OG5_129314	All targets in OG5_129314
Echinococcus multilocularis	tyrosine protein kinase Fyn	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma japonicum	Protein kinase C epsilon type, putative	Get druggable targets OG5_129314	All targets in OG5_129314
Echinococcus granulosus	tyrosine protein kinase Src64B	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma mansoni	tyrosine kinase	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	tyrosine kinase	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	tyrosine protein kinase Fyn	Get druggable targets OG5_127750	All targets in OG5_127750
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_132502	All targets in OG5_132502
Echinococcus multilocularis	tyrosine protein kinase HCK	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma japonicum	Proto-oncogene tyrosine-protein kinase FGR, putative	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma mansoni	tyrosine kinase	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	serine:threonine protein kinase N2	Get druggable targets OG5_129314	All targets in OG5_129314
Loa Loa (eye worm)	SRC-1	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	Get druggable targets OG5_127750	All targets in OG5_127750
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_132502	All targets in OG5_132502
Echinococcus multilocularis	tyrosine protein kinase Fyn	Get druggable targets OG5_127750	All targets in OG5_127750
Loa Loa (eye worm)	AGC/PKC/ETA protein kinase	Get druggable targets OG5_129314	All targets in OG5_129314
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	Get druggable targets OG5_127750	All targets in OG5_127750
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_132502	All targets in OG5_132502
Echinococcus granulosus	tyrosine protein kinase Fyn	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	tyrosine protein kinase Src42A	Get druggable targets OG5_127750	All targets in OG5_127750
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_132502	All targets in OG5_132502
Echinococcus granulosus	tyrosine protein kinase Blk	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma japonicum	Proto-oncogene tyrosine-protein kinase FYN, putative	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma japonicum	Proto-oncogene tyrosine-protein kinase Yrk, putative	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase Fyn	Get druggable targets OG5_127750	All targets in OG5_127750
Brugia malayi	SRC-1	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	tyrosine protein kinase Src42A	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	tyrosine protein kinase Lyn	Get druggable targets OG5_127750	All targets in OG5_127750
Entamoeba histolytica	PH domain containing protein kinase, putative	Get druggable targets OG5_129314	All targets in OG5_129314
Schistosoma japonicum	Proto-oncogene tyrosine-protein kinase FYN, putative	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	protein kinase c epsilon type	Get druggable targets OG5_129314	All targets in OG5_129314
Schistosoma japonicum	ko:K06068 novel protein kinase C, putative	Get druggable targets OG5_129314	All targets in OG5_129314
Brugia malayi	protein-tyrosine kinase	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase Src64B	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase Blk	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma japonicum	ko:K08892 fyn-related kinase, putative	Get druggable targets OG5_127750	All targets in OG5_127750
Brugia malayi	protein kinase C II.	Get druggable targets OG5_129314	All targets in OG5_129314
Echinococcus multilocularis	tyrosine protein kinase Fgr	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	tyrosine protein kinase HCK	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase Src42A	Get druggable targets OG5_127750	All targets in OG5_127750
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_132502	All targets in OG5_132502
Echinococcus granulosus	tyrosine protein kinase Fyn	Get druggable targets OG5_127750	All targets in OG5_127750
Entamoeba histolytica	protein kinase, putative	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase Src42A	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma japonicum	ko:K05703 proto-oncogene tyrosine-protein kinase Fyn, putative	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	protein kinase c epsilon type	Get druggable targets OG5_129314	All targets in OG5_129314
Loa Loa (eye worm)	TK protein kinase	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase Fyn	Get druggable targets OG5_127750	All targets in OG5_127750

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	calpain 7 C02 family	0.0019	0.0022	0.0099
Echinococcus granulosus	calpain	0.0019	0.0022	0.0099
Echinococcus multilocularis	SH2 domain containing protein 7	0.0023	0.0046	0.0203
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0064	0.0064
Onchocerca volvulus	Rap guanine nucleotide exchange factor 1 homolog	0.018	0.1081	0.1043
Echinococcus multilocularis	calpain family protein 1, d	0.0045	0.0193	0.0857
Echinococcus granulosus	myotubularin protein 13	0.0026	0.0064	0.0285
Entamoeba histolytica	hypothetical protein	0.0022	0.0042	0.002
Brugia malayi	diacylglycerol kinase	0.0026	0.0064	0.0064
Echinococcus multilocularis	calpain A	0.0068	0.0341	0.1509
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0023	0.0046	0.0203
Loa Loa (eye worm)	TK/FER protein kinase	0.0029	0.0088	0.0088
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0122	0.0696	0.3085
Onchocerca volvulus		0.1538	1	1
Brugia malayi	Phorbol esters/diacylglycerol binding domain	0.0026	0.007	0.007
Echinococcus granulosus	c src tyrosine kinase	0.0051	0.0233	0.1034
Toxoplasma gondii	AGC kinase	0.0036	0.0134	1
Echinococcus multilocularis	expressed protein	0.0022	0.0042	0.0187
Onchocerca volvulus		0.0023	0.0046	0.0004
Schistosoma mansoni	serine/threonine protein kinase	0.0036	0.0134	0.1447
Brugia malayi	SH2 domain containing protein	0.0029	0.0088	0.0088
Echinococcus granulosus	protein kinase c eta type	0.0026	0.0064	0.0285
Schistosoma mansoni	tensin	0.0023	0.0046	0.0495
Brugia malayi	hypothetical protein	0.0029	0.0088	0.0088
Echinococcus multilocularis	fch and double sh3 domains protein 2	0.0022	0.0042	0.0187
Echinococcus multilocularis	hypothetical protein	0.0019	0.0022	0.0099
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0046	0.0197	0.0197
Echinococcus granulosus	expressed protein	0.0022	0.0042	0.0187
Onchocerca volvulus		0.0023	0.0046	0.0004
Loa Loa (eye worm)	hypothetical protein	0.0034	0.012	0.012
Loa Loa (eye worm)	TK/FER protein kinase	0.0029	0.0088	0.0088
Echinococcus granulosus	C2 calcium dependent membrane targeting	0.0027	0.0074	0.033
Schistosoma mansoni	tensin	0.0023	0.0046	0.0495
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase abl1	0.0045	0.0192	0.2068
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0042	0.0042
Schistosoma mansoni	nck2/grb4	0.0045	0.0192	0.2068
Schistosoma mansoni	protein tyrosine phosphatase n11 (shp2)	0.0023	0.0046	0.0495
Echinococcus granulosus	tyrosine protein kinase shark	0.0029	0.0088	0.0389
Loa Loa (eye worm)	hypothetical protein	0.0333	0.2087	0.2087
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0046	0.0197	0.2122
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0064	0.0064
Echinococcus granulosus	hematopoietic lineage cell specific protein	0.0022	0.0042	0.0187
Echinococcus granulosus	calpain A	0.0019	0.0022	0.0099
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0051	0.0233	0.1034
Schistosoma mansoni	unc-13 (munc13)	0.0027	0.0074	0.0803
Onchocerca volvulus		0.0026	0.0064	0.0022
Brugia malayi	Calcitonin receptor-like protein seb-1	0.005	0.0224	0.0224
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0029	0.0088	0.0066
Brugia malayi	protein-tyrosine kinase	0.0022	0.0042	0.0042
Brugia malayi	SH2 domain containing protein	0.0023	0.0046	0.0046
Schistosoma mansoni	tyrosine kinase	0.0122	0.0696	0.7517
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0046	0.0197	0.0871
Echinococcus multilocularis	slit robo rho gtpase activating protein 1	0.0022	0.0042	0.0187
Entamoeba histolytica	protein kinase, putative	0.0036	0.0134	0.0112
Trichomonas vaginalis	AGC family protein kinase	0.0036	0.0134	0.0092
Brugia malayi	SH2 domain containing protein	0.0023	0.0046	0.0046
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0048	0.0214	0.2308
Schistosoma mansoni	Dab2-interacting protein-like	0.0022	0.0042	0.0455
Entamoeba histolytica	protein kinase, putative	0.0077	0.0401	0.038
Trichomonas vaginalis	low molecular weight protein tyrosine phosphatase, putative	0.1538	1	1
Brugia malayi	Protein kinase domain containing protein	0.0029	0.0088	0.0088
Echinococcus multilocularis	ribosomal protein s6 kinase beta 1	0.0036	0.0134	0.0594
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0046	0.0046
Brugia malayi	SRC-1	0.0122	0.0696	0.0696
Echinococcus multilocularis	SH2 motif	0.0023	0.0046	0.0203
Schistosoma mansoni	sh3-containing grb2-like protein 1 (endophilin II)	0.0022	0.0042	0.0455
Schistosoma mansoni	shc transforming protein	0.0023	0.0046	0.0495
Brugia malayi	SH2 domain containing protein	0.0023	0.0046	0.0046
Echinococcus granulosus	expressed conserved protein	0.0023	0.0046	0.0203
Schistosoma mansoni	adapter molecule crk	0.0045	0.0192	0.2068
Echinococcus granulosus	protein kinase c epsilon type	0.0147	0.0859	0.3808
Entamoeba histolytica	BAR/SH3 domain containing protein	0.0022	0.0042	0.002
Schistosoma mansoni	calpain-7 (C02 family)	0.0019	0.0022	0.024
Loa Loa (eye worm)	hypothetical protein	0.0369	0.2324	0.2324
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.0051	0.0233	0.1034
Onchocerca volvulus		0.0023	0.0046	0.0004
Echinococcus multilocularis	myotubularin protein 13	0.0026	0.0064	0.0285
Brugia malayi	calpain 5	0.0021	0.0032	0.0032
Trichomonas vaginalis	AGC family protein kinase	0.0036	0.0134	0.0092
Echinococcus multilocularis	protein kinase c eta type	0.0026	0.0064	0.0285
Brugia malayi	Protein kinase domain containing protein	0.0029	0.0088	0.0088
Brugia malayi	Protein kinase domain containing protein	0.0029	0.0088	0.0088
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0122	0.0696	0.3085
Trichomonas vaginalis	AGC family protein kinase	0.0036	0.0134	0.0092
Echinococcus granulosus	N chimaerin	0.0048	0.0214	0.0947
Trichomonas vaginalis	AGC family protein kinase	0.0036	0.0134	0.0092
Schistosoma mansoni	serine/threonine kinase	0.0036	0.0134	0.1447
Entamoeba histolytica	SH2 domain containing protein	0.0023	0.0046	0.0024
Loa Loa (eye worm)	cytokine inducible SH2-containing protein 5	0.0023	0.0046	0.0046
Loa Loa (eye worm)	TK protein kinase	0.0077	0.0401	0.0401
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.0068	0.0341	0.3678
Trichomonas vaginalis	low molecular weight protein tyrosine phosphatase, putative	0.0474	0.3011	0.2981
Entamoeba histolytica	protein tyrosine phosphatase, putative	0.1538	1	1
Brugia malayi	calpain family protein 1	0.0064	0.0319	0.0319
Trichomonas vaginalis	AGC family protein kinase	0.0036	0.0134	0.0092
Echinococcus granulosus	src region	0.0022	0.0042	0.0187
Echinococcus granulosus	protein kinase c iota type	0.0062	0.0302	0.1338
Entamoeba histolytica	hypothetical protein	0.0022	0.0042	0.002
Echinococcus multilocularis	calpain	0.0019	0.0022	0.0099
Trichomonas vaginalis	serine/threonine-protein kinase sgk, putative	0.0035	0.0129	0.0087
Onchocerca volvulus		0.0029	0.0088	0.0046
Brugia malayi	Protein kinase domain containing protein	0.0036	0.0134	0.0134
Echinococcus multilocularis	epidermal growth factor receptor kinase	0.0022	0.0042	0.0187
Onchocerca volvulus		0.0027	0.0074	0.0032
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.01	0.0551	0.244
Echinococcus granulosus	voltage dependent calcium channel subunit	0.0359	0.2257	1
Brugia malayi	Protein kinase domain containing protein	0.0036	0.0134	0.0134
Echinococcus granulosus	fch and double sh3 domains protein 2	0.0022	0.0042	0.0187
Echinococcus granulosus	tensin C1 domain containing phosphatase	0.0023	0.0046	0.0203
Schistosoma mansoni	growth factor receptor-bound protein	0.0045	0.0192	0.2068
Schistosoma mansoni	serine/threonine protein kinase	0.0063	0.0312	0.3367
Brugia malayi	Variant SH3 domain containing protein	0.0024	0.0056	0.0056
Echinococcus granulosus	tyrosine protein kinase ABL1	0.0029	0.0088	0.0389
Loa Loa (eye worm)	TK/ABL protein kinase	0.0029	0.0088	0.0088
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.0023	0.0046	0.0203
Echinococcus granulosus	tyrosine kinase	0.0029	0.0088	0.0389
Schistosoma mansoni	hypothetical protein	0.0084	0.0451	0.4869
Echinococcus multilocularis	tyrosine protein kinase shark	0.0029	0.0088	0.0389
Brugia malayi	Variant SH3 domain containing protein	0.0045	0.0192	0.0192
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0093	0.0509	0.2254
Entamoeba histolytica	hypothetical protein, conserved	0.0022	0.0042	0.002
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0122	0.0696	0.3085
Entamoeba histolytica	protein kinase, putative	0.0022	0.0042	0.002
Schistosoma mansoni	tyrosine kinase	0.0029	0.0088	0.0948
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0042	0.0042
Schistosoma mansoni	sorting nexin	0.0022	0.0042	0.0455
Trypanosoma brucei	conserved protein	0.0022	0.0042	0.0067
Schistosoma mansoni	serine/threonine protein kinase	0.0036	0.0134	0.1447
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.005	0.0224	0.0224
Trichomonas vaginalis	AGC family protein kinase	0.0036	0.0134	0.0092
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0042	0.0042
Brugia malayi	hypothetical protein	0.0023	0.0046	0.0046
Loa Loa (eye worm)	TK/FER protein kinase	0.0029	0.0088	0.0088
Echinococcus multilocularis	Ribosomal protein S6 kinase beta 2	0.0036	0.0134	0.0594
Echinococcus multilocularis	tyrosine protein kinase Srms	0.01	0.0551	0.244
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0064	0.0064
Loa Loa (eye worm)	AGC/NDR protein kinase	0.0036	0.0134	0.0134
Echinococcus multilocularis	SHC transforming protein 3	0.0023	0.0046	0.0203
Schistosoma mansoni	tyrosine-protein kinase zap-70	0.0023	0.0046	0.0495
Echinococcus granulosus	Spectrin alpha actinin	0.0022	0.0042	0.0187
Echinococcus multilocularis	signal transduction protein lnk realted	0.0023	0.0046	0.0203
Schistosoma mansoni	vav2	0.0048	0.0214	0.2308
Schistosoma mansoni	growth factor receptor-bound protein	0.0045	0.0192	0.2068
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0051	0.0233	0.2521
Echinococcus multilocularis	arf GAP with SH3 domain, ANK repeat and PH	0.0022	0.0042	0.0187
Echinococcus granulosus	NCK adaptor protein	0.0045	0.0192	0.0849
Entamoeba histolytica	protein kinase, putative	0.0024	0.0051	0.0029
Loa Loa (eye worm)	thyroid receptor interactor	0.0022	0.0042	0.0042
Trichomonas vaginalis	low molecular weight protein tyrosine phosphatase, putative	0.0474	0.3011	0.2981
Loa Loa (eye worm)	guanylate kinase	0.0022	0.0042	0.0042
Schistosoma mansoni	protein kinase C	0.0027	0.0074	0.0803
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0122	0.0696	0.3085
Echinococcus multilocularis	c src tyrosine kinase	0.0051	0.0233	0.1034
Trypanosoma brucei	low molecular weight protein tyrosine phosphatase, putative	0.0474	0.3011	1
Echinococcus multilocularis	tyrosine protein kinase Abl	0.0051	0.0233	0.1034
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0048	0.0214	0.2308
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0122	0.0696	0.3085
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0122	0.0696	0.3085
Echinococcus granulosus	arf GAP with SH3 domain ANK repeat and PH	0.0022	0.0042	0.0187
Echinococcus multilocularis	serine:threonine protein kinase N2	0.0036	0.0134	0.0594
Schistosoma mansoni	tensin-related	0.0023	0.0046	0.0495
Brugia malayi	Protein kinase domain containing protein	0.0026	0.007	0.007
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0064	0.0064
Brugia malayi	Src substrate cortactin	0.0022	0.0042	0.0042
Loa Loa (eye worm)	TK/FER protein kinase	0.0029	0.0088	0.0088
Trypanosoma cruzi	hypothetical protein, conserved	0.0474	0.3011	1
Brugia malayi	Protein kinase domain containing protein	0.0029	0.0088	0.0088
Brugia malayi	SH2 domain containing protein	0.0023	0.0046	0.0046
Schistosoma mansoni	serine/threonine protein kinase	0.0036	0.0134	0.1447
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0064	0.0064
Loa Loa (eye worm)	AGC/RSK/RSK protein kinase	0.0036	0.0134	0.0134
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0046	0.0046
Giardia lamblia	Low molecular weight protein-tyrosine-phosphatase	0.1538	1	0.5
Echinococcus granulosus	phosphatidylinositol 3 kinase regulatory subunit	0.0023	0.0046	0.0203
Schistosoma mansoni	development and differentiation-enhancing factor ddef	0.0022	0.0042	0.0455
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.0064	0.0319	0.3445
Onchocerca volvulus		0.0029	0.0088	0.0046
Schistosoma mansoni	dreadlocks/dock	0.0022	0.0042	0.0455
Trichomonas vaginalis	AGC family protein kinase	0.0036	0.0134	0.0092
Brugia malayi	latrophilin 2 splice variant baaae	0.0034	0.012	0.012
Brugia malayi	Peripheral plasma membrane protein CASK	0.0022	0.0042	0.0042
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0042	0.0042
Echinococcus granulosus	serine:threonine protein kinase N2	0.0084	0.0449	0.1991
Trichomonas vaginalis	low molecular weight protein tyrosine phosphatase, putative	0.1538	1	1
Schistosoma mansoni	tensin-related	0.0023	0.0046	0.0495
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0122	0.0696	0.3085
Echinococcus multilocularis	calpain 7 (C02 family)	0.0019	0.0022	0.0099
Brugia malayi	diacylglycerol kinase	0.0026	0.0064	0.0064
Echinococcus multilocularis	C2 calcium dependent membrane targeting	0.0027	0.0074	0.033
Loa Loa (eye worm)	Ras association domain family 1 isoform A	0.0026	0.0064	0.0064
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0093	0.0509	0.2254
Entamoeba histolytica	hypothetical protein	0.0022	0.0042	0.002
Schistosoma mansoni	signal transducing adapter molecule (stam)	0.0022	0.0042	0.0455
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0042	0.0042
Onchocerca volvulus		0.0023	0.0047	0.0005
Schistosoma mansoni	GTPase activating protein	0.0023	0.0046	0.0495
Loa Loa (eye worm)	protein-tyrosine kinase	0.0022	0.0042	0.0042
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.01	0.0551	0.244
Brugia malayi	SH2 domain containing protein	0.0023	0.0046	0.0046
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0046	0.0046
Entamoeba histolytica	hypothetical protein	0.0022	0.0042	0.002
Echinococcus granulosus	SHC transforming protein 3	0.0023	0.0046	0.0203
Schistosoma mansoni	serine/threonine protein kinase	0.0063	0.0312	0.3367
Schistosoma mansoni	serine/threonine protein kinase	0.0032	0.0106	0.1148
Echinococcus multilocularis	endophilin A3	0.0022	0.0042	0.0187
Echinococcus granulosus	epidermal growth factor receptor kinase	0.0022	0.0042	0.0187
Loa Loa (eye worm)	TK protein kinase	0.01	0.0551	0.0551
Brugia malayi	Protein kinase domain containing protein	0.0029	0.0088	0.0088
Brugia malayi	Variant SH3 domain containing protein	0.0022	0.0042	0.0042
Loa Loa (eye worm)	SH2 domain-containing protein	0.0023	0.0046	0.0046
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0122	0.0696	0.3085
Onchocerca volvulus		0.0023	0.0046	0.0004
Brugia malayi	Variant SH3 domain containing protein	0.0022	0.0042	0.0042
Trichomonas vaginalis	low molecular weight protein tyrosine phosphatase, putative	0.1538	1	1
Echinococcus multilocularis	voltage dependent calcium channel subunit	0.0163	0.097	0.4298
Loa Loa (eye worm)	hypothetical protein	0.005	0.0224	0.0224
Loa Loa (eye worm)	calpain family protein 1	0.0064	0.0319	0.0319
Loa Loa (eye worm)	hypothetical protein	0.0064	0.0319	0.0319
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0193	0.0193
Echinococcus multilocularis	Spectrin alpha actinin	0.0022	0.0042	0.0187
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0046	0.0197	0.2122
Schistosoma mansoni	calpain (C02 family)	0.0019	0.0022	0.024
Echinococcus multilocularis	raf serine:threonine protein kinase	0.0032	0.0106	0.0471
Trichomonas vaginalis	low molecular weight protein-tyrosine-phosphatase, putative	0.1538	1	1
Schistosoma mansoni	dihydropyridine-sensitive l-type calcium channel	0.0157	0.0926	1
Echinococcus multilocularis	tensin	0.0023	0.0046	0.0203
Echinococcus granulosus	tensin	0.0023	0.0046	0.0203
Loa Loa (eye worm)	AGC/PKC/IOTA protein kinase	0.0026	0.007	0.007
Schistosoma mansoni	SH2A	0.0023	0.0046	0.0495
Echinococcus multilocularis	serine:threonine protein kinase N2	0.0119	0.0682	0.302
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0064	0.0064
Schistosoma mansoni	rac gtpase activating protein	0.0026	0.0064	0.0696
Loa Loa (eye worm)	AGC/PKC/ETA protein kinase	0.0147	0.0859	0.0859
Schistosoma mansoni	diacylglycerol kinase theta	0.0026	0.0064	0.0696
Echinococcus granulosus	suppressor of cytokine signaling 7	0.0023	0.0046	0.0203
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0122	0.0696	0.3085
Onchocerca volvulus		0.0026	0.0064	0.0022
Entamoeba histolytica	hypothetical protein	0.0026	0.0064	0.0042
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0046	0.0046
Onchocerca volvulus		0.0029	0.0088	0.0046
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0046	0.0046
Schistosoma mansoni	hypothetical protein	0.0034	0.012	0.1296
Echinococcus multilocularis	tyrosine kinase	0.0029	0.0088	0.0389
Echinococcus granulosus	hypothetical protein	0.0023	0.0046	0.0203
Loa Loa (eye worm)	hypothetical protein	0.0064	0.0319	0.0319
Brugia malayi	Ras association domain family 1 isoform A	0.0026	0.0064	0.0064
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0088	0.0088
Trypanosoma cruzi	paraflagellar rod protein 5, putative	0.0022	0.0042	0.0067
Schistosoma mansoni	apoptosis stimulating of P53	0.0022	0.0042	0.0455
Echinococcus granulosus	Protein kinase C brain isozyme	0.0063	0.0312	0.1382
Echinococcus multilocularis	transfer RNA-Ala	0.0022	0.0042	0.0187
Entamoeba histolytica	hypothetical protein	0.0022	0.0042	0.002
Brugia malayi	calpain 7	0.0019	0.0022	0.0022
Echinococcus granulosus	intersectin 2	0.0024	0.0052	0.0231
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0024	0.0056	0.0056
Schistosoma mansoni	dynamin-associated protein	0.0022	0.0042	0.0455
Schistosoma mansoni	signal transduction protein lnk-related	0.0023	0.0046	0.0495
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0122	0.0696	0.3085
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0024	0.0051	0.0029
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0023	0.0046	0.0046
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0046	0.0046
Echinococcus multilocularis	SH2 domain containing adapter protein F	0.0023	0.0046	0.0203
Schistosoma mansoni	unc-13 (munc13)	0.0027	0.0074	0.0803
Brugia malayi	STAT protein, DNA binding domain containing protein	0.0023	0.0046	0.0046
Trichomonas vaginalis	AGC family protein kinase	0.0036	0.0134	0.0092
Loa Loa (eye worm)	AGC/RSK/P70 protein kinase	0.0036	0.0134	0.0134
Loa Loa (eye worm)	hypothetical protein	0.0333	0.2087	0.2087
Brugia malayi	Variant SH3 domain containing protein	0.0045	0.0192	0.0192
Echinococcus granulosus	NDR protein kinase	0.0036	0.0134	0.0594
Onchocerca volvulus		0.0029	0.0088	0.0046
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0042	0.0042
Echinococcus granulosus	raf serine:threonine protein kinase	0.0032	0.0106	0.0471
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.005	0.0224	0.0224
Schistosoma mansoni	tyrosine kinase	0.0051	0.0233	0.2521
Loa Loa (eye worm)	hypothetical protein	0.0359	0.2255	0.2255
Loa Loa (eye worm)	CAMK/PKD protein kinase	0.0026	0.007	0.007
Echinococcus granulosus	tyrosine kinase	0.01	0.0551	0.244
Echinococcus granulosus	nostrin	0.0022	0.0042	0.0187
Trypanosoma cruzi	hypothetical protein, conserved	0.0474	0.3011	1
Schistosoma mansoni	atypical protein kinase C	0.0062	0.0302	0.3259
Schistosoma mansoni	serine/threonine protein kinase	0.0026	0.007	0.0751
Brugia malayi	cytokine inducible SH2-containing protein 5	0.0023	0.0046	0.0046
Echinococcus multilocularis	calpain 5	0.0021	0.0032	0.0143
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0122	0.0696	0.3085
Echinococcus granulosus	unc 13 munc13	0.0027	0.0074	0.033
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0023	0.0046	0.0203
Brugia malayi	Variant SH3 domain containing protein	0.0022	0.0042	0.0042
Echinococcus granulosus	protein kinase C gamma type	0.0038	0.0144	0.0638
Echinococcus granulosus	Serine/threonine-protein kinase Genghis Khan	0.0026	0.007	0.0308
Echinococcus granulosus	suppressor of cytokine signaling 6	0.0023	0.0046	0.0203
Brugia malayi	RhoGAP domain containing protein	0.0048	0.0214	0.0214
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0046	0.0046
Loa Loa (eye worm)	SRC-1	0.0122	0.0696	0.0696
Echinococcus granulosus	rho guanine nucleotide exchange factor 7	0.0022	0.0042	0.0187
Trypanosoma cruzi	hypothetical protein, conserved	0.0022	0.0042	0.0067
Echinococcus granulosus	calpain 5	0.0021	0.0032	0.0143
Brugia malayi	protein kinase C II.	0.0147	0.0859	0.0859
Brugia malayi	Myosin tail family protein	0.0022	0.0042	0.0042
Echinococcus granulosus	breast cancer anti estrogen resistance protein	0.0022	0.0042	0.0187
Schistosoma mansoni	calpain C (C02 family)	0.0019	0.0022	0.024
Schistosoma mansoni	run and tbc1 domain containing	0.0022	0.0042	0.0455
Entamoeba histolytica	BAR/SH3 domain containing protein	0.0022	0.0042	0.002
Schistosoma mansoni	tyrosine kinase	0.0029	0.0088	0.0948
Entamoeba histolytica	protein tyrosine phosphatase, putative	0.1538	1	1
Entamoeba histolytica	diacylglycerol kinase, putative	0.0026	0.0064	0.0042
Trichomonas vaginalis	low molecular weight protein-tyrosine-phosphatase, putative	0.1538	1	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0029	0.0088	0.0088
Schistosoma mansoni	tensin	0.0023	0.0046	0.0495
Schistosoma mansoni	suppressor of cytokine signaling	0.0023	0.0046	0.0495
Echinococcus multilocularis	tensin	0.0023	0.0046	0.0203
Echinococcus granulosus	growth factor receptor bound protein 2	0.0045	0.0192	0.0849
Echinococcus granulosus	SH2 domain containing adapter protein F	0.0023	0.0046	0.0203
Loa Loa (eye worm)	phosphotyrosine protein phosphatase	0.1538	1	1
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0046	0.0197	0.0197
Brugia malayi	Guanylate kinase family protein	0.0022	0.0042	0.0042
Trypanosoma cruzi	hypothetical protein, conserved	0.0022	0.0042	0.0067
Loa Loa (eye worm)	protein kinase C and casein kinase substrate in neurons protein 2	0.0022	0.0042	0.0042
Schistosoma mansoni	hypothetical protein	0.0023	0.0046	0.0495
Echinococcus multilocularis	serine:threonine protein kinase 38	0.0036	0.0134	0.0594
Echinococcus granulosus	tyrosine protein kinase Srms	0.0029	0.0088	0.0389
Brugia malayi	calpain family protein 1	0.0064	0.0319	0.0319
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0022	0.0042	0.0042
Schistosoma mansoni	eps8-related protein	0.0022	0.0042	0.0455
Echinococcus multilocularis	growth factor receptor bound protein 2	0.0045	0.0192	0.0849
Schistosoma mansoni	protein kinase C mu	0.0026	0.0064	0.0696
Loa Loa (eye worm)	TK/FER protein kinase	0.0029	0.0088	0.0088
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0193	0.0193
Brugia malayi	RhoGAP domain containing protein	0.0026	0.0064	0.0064
Echinococcus granulosus	tyrosine protein kinase Blk	0.01	0.0551	0.244
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0046	0.0046
Brugia malayi	SH2 domain containing protein	0.0023	0.0046	0.0046
Schistosoma mansoni	C-fyn	0.0022	0.0042	0.0455
Echinococcus granulosus	tyrosine protein kinase Fps85D	0.0029	0.0088	0.0389
Schistosoma mansoni	serine/threonine protein kinase	0.0036	0.0134	0.1447
Schistosoma mansoni	sorbin	0.0022	0.0042	0.0455
Entamoeba histolytica	hypothetical protein	0.0022	0.0042	0.002
Brugia malayi	SH2 domain containing protein	0.0023	0.0046	0.0046
Echinococcus granulosus	endophilin A3	0.0022	0.0042	0.0187
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0122	0.0701	0.3108
Schistosoma mansoni	suppressor of cytokine signaling	0.0023	0.0046	0.0495
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0122	0.0696	0.3085
Echinococcus multilocularis	Diacylglycerol kinase theta	0.0026	0.0064	0.0285
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0045	0.0192	0.0192
Loa Loa (eye worm)	calpain family protein 1	0.0045	0.0193	0.0193
Loa Loa (eye worm)	hypothetical protein	0.018	0.1081	0.1081
Echinococcus granulosus	slit robo rho gtpase activating protein 1	0.0022	0.0042	0.0187
Echinococcus granulosus	Rac GTPase activating protein 1	0.0026	0.0064	0.0285
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0122	0.0696	0.3085
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0046	0.0046
Schistosoma mansoni	calpain-7 (C02 family)	0.0019	0.0022	0.024
Loa Loa (eye worm)	SH2 domain-containing protein	0.0023	0.0046	0.0046
Entamoeba histolytica	hypothetical protein	0.0022	0.0042	0.002
Brugia malayi	Sex muscle abnormal protein 5	0.0045	0.0192	0.0192
Echinococcus multilocularis	NCK adaptor protein	0.0045	0.0192	0.0849
Brugia malayi	protein-tyrosine kinase	0.01	0.0551	0.0551
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0042	0.0042
Schistosoma mansoni	hypothetical protein	0.0026	0.0064	0.0696
Brugia malayi	Pleckstrin Homology Domain	0.0026	0.0064	0.0064
Loa Loa (eye worm)	hypothetical protein	0.0333	0.2087	0.2087
Onchocerca volvulus		0.0333	0.2087	0.2053
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.0029	0.0088	0.0389
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0064	0.0064
Schistosoma mansoni	serine-rich repeat protein	0.0084	0.0451	0.4869
Schistosoma mansoni	Mername-AA248 (C02 family)	0.0021	0.0032	0.0348
Leishmania major	hypothetical protein, conserved	0.0474	0.3011	1
Loa Loa (eye worm)	AGC/PKN protein kinase	0.0036	0.0134	0.0134
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0074	0.0074
Plasmodium vivax	calpain, putative	0.0019	0.0022	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0029	0.0088	0.0088
Entamoeba histolytica	protein kinase, putative	0.002	0.0027	0.0005
Echinococcus granulosus	tyrosine protein kinase HCK	0.0077	0.0401	0.1778
Echinococcus multilocularis	hematopoietic lineage cell specific protein	0.0022	0.0042	0.0187
Loa Loa (eye worm)	STAT protein	0.0023	0.0046	0.0046
Brugia malayi	Cache domain containing protein	0.0072	0.0372	0.0372
Brugia malayi	SH3 domain containing protein	0.0022	0.0042	0.0042
Loa Loa (eye worm)	AGC/RSK/MSK protein kinase	0.0036	0.0134	0.0134
Brugia malayi	Protein kinase c protein 2	0.0028	0.008	0.008
Entamoeba histolytica	hypothetical protein	0.0022	0.0042	0.002
Echinococcus multilocularis	phosphatidylinositol 3 kinase regulatory subunit	0.0023	0.0046	0.0203
Loa Loa (eye worm)	p53BP2	0.0022	0.0042	0.0042
Entamoeba histolytica	protein kinase, putative	0.0036	0.0134	0.0112
Trypanosoma brucei	rac serine-threonine kinase, putative	0.0036	0.0134	0.0374
Echinococcus multilocularis	rho guanine nucleotide exchange factor 7	0.0022	0.0042	0.0187
Brugia malayi	RhoGEF domain containing protein	0.0026	0.0064	0.0064
Loa Loa (eye worm)	AGC/DMPK/GEK protein kinase	0.0036	0.0134	0.0134
Onchocerca volvulus		0.0029	0.0088	0.0046
Loa Loa (eye worm)	SH2 domain-containing protein	0.0023	0.0046	0.0046
Brugia malayi	Tyrosine-protein kinase abl-1	0.0051	0.0233	0.0233
Echinococcus multilocularis	intersectin 2	0.0024	0.0052	0.0231
Brugia malayi	Variant SH3 domain containing protein	0.0022	0.0042	0.0042
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0046	0.0197	0.0871
Brugia malayi	Variant SH3 domain containing protein	0.0048	0.0214	0.0214
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0064	0.0064
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.0023	0.0046	0.0203
Entamoeba histolytica	diacylglycerol kinase, putative	0.0026	0.0064	0.0042
Echinococcus multilocularis	tyrosine protein kinase Fps85D	0.0029	0.0088	0.0389
Loa Loa (eye worm)	TK/FER protein kinase	0.0029	0.0088	0.0088
Schistosoma mansoni	hypothetical protein	0.0023	0.0046	0.0495
Trichomonas vaginalis	AGC family protein kinase	0.0036	0.0134	0.0092
Brugia malayi	C1-like domain containing protein	0.0026	0.007	0.007
Echinococcus granulosus	ribosomal protein s6 kinase beta 1	0.0036	0.0134	0.0594
Trichomonas vaginalis	AGC family protein kinase	0.0036	0.0134	0.0092
Loa Loa (eye worm)	calpain 5	0.0019	0.0022	0.0022
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0122	0.0696	0.3085
Schistosoma mansoni	serine/threonine protein kinase	0.0026	0.007	0.0751
Onchocerca volvulus	Suppressor of cytokine signaling at 36E homolog	0.0023	0.0046	0.0004
Echinococcus multilocularis	unc 13 (munc13)	0.0027	0.0074	0.033
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0042	0.0042
Loa Loa (eye worm)	RhoGAP domain-containing protein	0.0048	0.0214	0.0214
Schistosoma mansoni	hypothetical protein	0.0022	0.0042	0.0455
Brugia malayi	Protein kinase domain containing protein	0.0036	0.0134	0.0134
Echinococcus granulosus	calpain A	0.0068	0.0341	0.1509
Onchocerca volvulus		0.0045	0.0193	0.0152
Loa Loa (eye worm)	RasGEF domain-containing protein	0.0028	0.0078	0.0078
Loa Loa (eye worm)	TK/FER protein kinase	0.0029	0.0088	0.0088
Echinococcus granulosus	Diacylglycerol kinase theta	0.0026	0.0064	0.0285
Echinococcus multilocularis	serine:threonine protein kinase MRCK beta	0.0026	0.007	0.0308
Echinococcus granulosus	family C2 unassigned peptidase C02 family	0.0068	0.0341	0.1509
Schistosoma mansoni	tyrosine kinase	0.0122	0.0696	0.7517
Schistosoma mansoni	formin binding protein and related proteins	0.0022	0.0042	0.0455
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.0068	0.0341	0.3678
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0064	0.0064
Echinococcus multilocularis	suppressor of cytokine signaling 6	0.0023	0.0046	0.0203
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0046	0.0046
Brugia malayi	Tensin	0.0023	0.0046	0.0046
Entamoeba histolytica	protein kinase, putative	0.0036	0.0134	0.0112
Echinococcus granulosus	SH2 domain containing protein 7	0.0023	0.0046	0.0203
Echinococcus multilocularis	guanine nucleotide exchange factor VAV2	0.0048	0.0214	0.0947
Loa Loa (eye worm)	TK/FER protein kinase	0.0029	0.0088	0.0088
Echinococcus multilocularis	N chimaerin	0.0048	0.0214	0.0947
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0026	0.0064	0.0064
Schistosoma mansoni	tyrosine kinase	0.0051	0.0233	0.2521
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0084	0.0449	0.0428
Echinococcus multilocularis	protein kinase c epsilon type	0.0147	0.0859	0.3808
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0046	0.0197	0.0871
Echinococcus multilocularis	voltage dependent calcium channel subunit	0.0359	0.2257	1
Echinococcus multilocularis	family C2 unassigned peptidase (C02 family)	0.0068	0.0341	0.1509
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0046	0.0197	0.0871
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0046	0.0046
Brugia malayi	protein kinase C3,putative	0.0026	0.007	0.007
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0122	0.0696	0.3085
Echinococcus multilocularis		0.0023	0.0046	0.0203
Schistosoma mansoni	serine/threonine protein kinase	0.0147	0.0859	0.9279
Mycobacterium ulcerans	phosphotyrosine protein phosphatase PtpA	0.1538	1	0.5
Schistosoma mansoni	protein kinase C mu	0.0026	0.007	0.0751
Schistosoma mansoni	cell polarity protein	0.0022	0.0042	0.0455
Schistosoma mansoni	dihydropyridine-sensitive l-type calcium channel	0.0079	0.0416	0.4487
Echinococcus multilocularis	tyrosine protein kinase HCK	0.0077	0.0401	0.1778
Echinococcus granulosus	signal transduction protein lnk realted	0.0023	0.0046	0.0203
Brugia malayi	N-terminal motif family protein	0.018	0.1081	0.1081
Schistosoma mansoni	slit-robo rho gtpase activating protein	0.0022	0.0042	0.0455
Echinococcus granulosus	SH2 motif	0.0023	0.0046	0.0203
Brugia malayi	p70 ribosomal S6 kinase beta	0.0036	0.0134	0.0134
Echinococcus granulosus	serine:threonine protein kinase N2	0.0036	0.0134	0.0594
Schistosoma mansoni	hypothetical protein	0.0022	0.0042	0.0455
Loa Loa (eye worm)	raf kinase	0.0026	0.0064	0.0064
Echinococcus multilocularis	serine threonine protein kinase	0.0038	0.0144	0.0638
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0023	0.0046	0.0046
Brugia malayi	Hr1 repeat family protein	0.0036	0.0134	0.0134
Brugia malayi	Variant SH3 domain containing protein	0.0022	0.0042	0.0042
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0023	0.0046	0.0203
Leishmania major	hypothetical protein, conserved	0.0022	0.0042	0.0067
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0046	0.0197	0.2122
Echinococcus multilocularis	Protein kinase C, brain isozyme	0.0063	0.0312	0.1382
Trichomonas vaginalis	AGC family protein kinase	0.0036	0.0134	0.0092
Onchocerca volvulus	Suppressor of cytokine signaling 7 homolog	0.0023	0.0046	0.0004
Echinococcus multilocularis	tyrosine protein kinase Blk	0.01	0.0551	0.244
Echinococcus multilocularis	protein kinase c iota type	0.0062	0.0302	0.1338
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0122	0.0696	0.3085
Loa Loa (eye worm)	sex muscle abnormal protein 5	0.0045	0.0192	0.0192
Brugia malayi	Variant SH3 domain containing protein	0.0022	0.0042	0.0042
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0023	0.0046	0.0203
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0046	0.0046
Echinococcus multilocularis	SH2 motif	0.0023	0.0046	0.0203
Echinococcus multilocularis	SH2 motif	0.0023	0.0046	0.0203
Loa Loa (eye worm)	AGC/AKT protein kinase	0.0036	0.0134	0.0134
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0046	0.0046
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0042	0.0042
Loa Loa (eye worm)	calpain	0.0019	0.0022	0.0022
Mycobacterium tuberculosis	Phosphotyrosine protein phosphatase PtpA (protein-tyrosine-phosphatase) (PTPase) (LMW phosphatase)	0.1064	0.6886	0.5
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0064	0.0064
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0192	0.0192
Brugia malayi	SH2 domain containing protein	0.0029	0.0088	0.0088
Echinococcus multilocularis	breast cancer anti estrogen resistance protein	0.0022	0.0042	0.0187
Onchocerca volvulus		0.0029	0.0088	0.0046
Onchocerca volvulus		0.0023	0.0046	0.0004
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0046	0.0046
Echinococcus multilocularis	ribosomal protein S6 kinase alpha 3	0.0036	0.0134	0.0594
Trypanosoma cruzi	hypothetical protein, conserved	0.0022	0.0042	0.0067
Echinococcus multilocularis	Rac GTPase activating protein 1	0.0026	0.0064	0.0285
Echinococcus granulosus	guanine nucleotide exchange factor VAV2	0.0048	0.0214	0.0947
Schistosoma mansoni	diacylglycerol kinase theta	0.0026	0.0064	0.0696
Trichomonas vaginalis	low molecular weight protein-tyrosine-phosphatase, putative	0.1538	1	1
Onchocerca volvulus		0.0023	0.0046	0.0004
Loa Loa (eye worm)	hypothetical protein	0.0072	0.0372	0.0372
Brugia malayi	Fes/CIP4 homology domain containing protein	0.0022	0.0042	0.0042
Entamoeba histolytica	protein kinase, putative	0.0036	0.0134	0.0112
Entamoeba histolytica	hypothetical protein, conserved	0.0022	0.0042	0.002
Echinococcus granulosus	Ribosomal protein S6 kinase beta 2	0.0036	0.0134	0.0594
Echinococcus granulosus	ribosomal protein S6 kinase alpha 3	0.0036	0.0134	0.0594
Entamoeba histolytica	unconventional myosin IB	0.0022	0.0042	0.002
Schistosoma mansoni	serine/threonine protein kinase	0.0029	0.0084	0.0908
Brugia malayi	tRNA modification GTPase TrmE family protein	0.0023	0.0046	0.0046
Echinococcus multilocularis	nostrin	0.0022	0.0042	0.0187
Brugia malayi	Spectrin alpha chain	0.0022	0.0042	0.0042
Echinococcus granulosus	voltage dependent calcium channel subunit	0.0163	0.097	0.4298
Echinococcus granulosus	SH2 motif	0.0023	0.0046	0.0203

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 3.8 nM	Inhibition of PKCtheta	ChEMBL.	18606543
IC50 (binding)	= 25 nM	Inhibition of FYN	ChEMBL.	18606543
IC50 (binding)	= 26 nM	Inhibition of HCK	ChEMBL.	18606543
IC50 (binding)	= 28 nM	Inhibition of LYN	ChEMBL.	18606543
IC50 (binding)	= 46 nM	Inhibition of LCK	ChEMBL.	18606543
IC50 (binding)	= 330 nM	Inhibition of SRC	ChEMBL.	18606543
IC50 (binding)	= 1300 nM	Inhibition of PKCdelta	ChEMBL.	18606543
IC50 (binding)	= 3000 nM	Inhibition of PKCepsilon	ChEMBL.	18606543
IC50 (binding)	> 20000 nM	Inhibition of ITK	ChEMBL.	18606543
IC50 (binding)	> 50000 nM	Inhibition of PDGFRalpha	ChEMBL.	18606543
IC50 (binding)	> 50000 nM	Inhibition of MET	ChEMBL.	18606543
IC50 (binding)	> 50000 nM	Inhibition of IKK-beta	ChEMBL.	18606543
IC50 (binding)	> 50000 nM	Inhibition of IKKalpha	ChEMBL.	18606543
IC50 (binding)	> 50000 nM	Inhibition of ROCK1	ChEMBL.	18606543
IC50 (binding)	> 50000 nM	Inhibition of PKCalpha	ChEMBL.	18606543
IC50 (binding)	> 50000 nM	Inhibition of VEGFR2	ChEMBL.	18606543
IC50 (binding)	> 50000 nM	Inhibition of CHK1	ChEMBL.	18606543
IC50 (binding)	> 50000 nM	Inhibition of RSK1	ChEMBL.	18606543
IC50 (binding)	> 50000 nM	Inhibition of P38alpha	ChEMBL.	18606543
IC50 (binding)	> 50000 nM	Inhibition of MK2	ChEMBL.	18606543
IC50 (binding)	> 50000 nM	Inhibition of CDK1/cyclinB	ChEMBL.	18606543
IC50 (binding)	> 50000 nM	Inhibition of ERK2	ChEMBL.	18606543
IC50 (binding)	> 50000 nM	Inhibition of CK1gamma1	ChEMBL.	18606543
IC50 (binding)	> 50000 nM	Inhibition of Aurora B	ChEMBL.	18606543
IC50 (binding)	= 51000 nM	Inhibition of PKCeta	ChEMBL.	18606543
IC50 (binding)	> 100000 nM	Inhibition of PKCbeta	ChEMBL.	18606543
IC50 (binding)	> 100000 nM	Inhibition of PKCzeta	ChEMBL.	18606543

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL477817

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 979258