TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 366.857 | Formula: C19H24ClFN2O2
H donors: 0 H acceptors: 1 LogP: 4.29 Rotable bonds: 8
Rule of 5 violations (Lipinski): 1
SMILES: FCCCCc1ccc(cc1)COc1cnn(c(=O)c1Cl)C(C)(C)C
InChi: 1S/C19H24ClFN2O2/c1-19(2,3)23-18(24)17(20)16(12-22-23)25-13-15-9-7-14(8-10-15)6-4-5-11-21/h7-10,12H,4-6,11,13H2,1-3H3
InChiKey: KXTQTSAQSJMKLA-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	phosphoglycerate mutase	0.0039	0.0039	0.0034
Schistosoma mansoni	sodium/chloride dependent transporter	0.0185	0.068	0.0675
Leishmania major	hypothetical protein, conserved	0.0039	0.0039	0.0027
Brugia malayi	phosphoglycerate mutase family protein	0.0039	0.0039	0.0073
Echinococcus multilocularis	phosphoglycerate mutase	0.0039	0.0039	0.0034
Entamoeba histolytica	phosphoglycerate mutase family protein, putative	0.0039	0.0039	0.004
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	0.0185	0.068	0.0675
Trichomonas vaginalis	conserved hypothetical protein	0.0039	0.0039	0.3738
Echinococcus multilocularis	phosphoglycerate mutase	0.0039	0.0039	0.0034
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0033	0.0012	0.0009
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0034	0.0015	0.0512
Loa Loa (eye worm)	hypothetical protein	0.0185	0.068	0.0677
Echinococcus granulosus	serotonin transporter	0.109	0.465	0.4647
Toxoplasma gondii	phosphoglycerate mutase PGMII	0.0039	0.0039	0.0407
Mycobacterium ulcerans	hypothetical protein	0.1363	0.5848	1
Loa Loa (eye worm)	hypothetical protein	0.0185	0.068	0.0677
Leishmania major	phosphoglycerate mutase family member 5, putative	0.0039	0.0039	0.0027
Mycobacterium tuberculosis	PE-PGRS family protein PE_PGRS11	0.0039	0.0039	0.0495
Brugia malayi	beta-lactamase	0.0033	0.0012	0.0015
Toxoplasma gondii	phosphoglycerate mutase family protein	0.0039	0.0039	0.0407
Mycobacterium tuberculosis	Conserved protein	0.0039	0.0039	0.0495
Trypanosoma cruzi	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatas, putative	0.0039	0.0039	0.0027
Mycobacterium leprae	PROBABLE PHOSPHOGLYCERATE MUTASE (PHOSPHOGLYCEROMUTASE)	0.0039	0.0039	1
Trypanosoma brucei	Serine/threonine-protein phosphatase PGAM5, mitochondrial, putative	0.0039	0.0039	0.0027
Mycobacterium leprae	Possible phosphoglycerate mutase	0.0039	0.0039	1
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.0185	0.068	0.0675
Toxoplasma gondii	phosphoglycerate mutase family protein	0.0039	0.0039	0.0407
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0005	0.0003
Onchocerca volvulus		0.0033	0.0012	0.0007
Echinococcus multilocularis	sodium and chloride dependent glycine	0.0185	0.068	0.0675
Mycobacterium ulcerans	lipoprotein LpqD	0.0039	0.0039	0.0047
Trypanosoma cruzi	Histidine phosphatase superfamily (branch 1), putative	0.0039	0.0039	0.0027
Mycobacterium tuberculosis	Possible phosphoglycerate mutase Gpm2 (phosphoglyceromutase) (PGAM) (BPG-dependent PGAM)	0.0039	0.0039	0.0495
Toxoplasma gondii	phosphoglycerate mutase family protein	0.0039	0.0039	0.0407
Trypanosoma brucei	Histidine phosphatase superfamily (branch 1), putative	0.0039	0.0039	0.0027
Trypanosoma cruzi	phosphoglycerate mutase protein, putative	0.0039	0.0039	0.0027
Plasmodium vivax	amine transporter, putative	0.0185	0.068	1
Leishmania major	hypothetical protein, conserved	0.0039	0.0039	0.0027
Trypanosoma cruzi	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative	0.0985	0.4191	0.4184
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0185	0.068	0.1453
Mycobacterium ulcerans	hydrolase MutT1	0.0039	0.0039	0.0047
Schistosoma mansoni	sodium/chloride dependent transporter	0.0185	0.068	0.0675
Mycobacterium tuberculosis	Probable esterase LipL	0.0033	0.0012	0.0149
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0033	0.0012	0.0149
Mycobacterium tuberculosis	Conserved protein	0.0033	0.0012	0.0149
Toxoplasma gondii	histone lysine acetyltransferase GCN5-A	0.0049	0.0084	0.1089
Onchocerca volvulus	Protein UBASH3A homolog	0.0039	0.0039	0.0034
Echinococcus multilocularis	serine:threonine protein phosphatase PGAM5	0.0039	0.0039	0.0034
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0033	0.0012	0.0007
Brugia malayi	Sodium:neurotransmitter symporter family protein 1, putative	0.0185	0.068	0.1453
Trypanosoma cruzi	Histidine phosphatase superfamily (branch 1), putative	0.0039	0.0039	0.0027
Trypanosoma cruzi	Histidine phosphatase superfamily (branch 1), putative	0.0039	0.0039	0.0027
Entamoeba histolytica	acetyltransferase, GNAT family	0.0045	0.0066	0.0087
Onchocerca volvulus		0.0039	0.0039	0.0034
Leishmania major	fructose-6-phosphate2-kinase/fructose-2,6-bisph os phatase-likeprotein	0.0039	0.0039	0.0027
Loa Loa (eye worm)	acetyltransferase	0.0168	0.0604	0.0602
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0049	0.0084	0.008
Echinococcus multilocularis	serine:threonine protein phosphatase PGAM5	0.0039	0.0039	0.0034
Loa Loa (eye worm)	intermediate filament protein	0.0031	0.0005	0.0003
Plasmodium vivax	hypothetical protein, conserved	0.0185	0.068	1
Toxoplasma gondii	Sodium:neurotransmitter symporter family protein	0.0185	0.068	1
Brugia malayi	beta-lactamase family protein	0.0033	0.0012	0.0015
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0034	0.0015	0.0512
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	0.0185	0.068	0.0675
Echinococcus granulosus	sodium:chloride dependent neurotransmitter	0.0185	0.068	0.0675
Trypanosoma cruzi	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative	0.0985	0.4191	0.4184
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0012	0.0009
Mycobacterium tuberculosis	Conserved protein	0.0033	0.0012	0.0149
Giardia lamblia	Hypothetical protein	0.1363	0.5848	1
Mycobacterium tuberculosis	Conserved protein	0.0039	0.0039	0.0495
Echinococcus multilocularis	uncharacterized sodium dependent transporter	0.0185	0.068	0.0675
Toxoplasma gondii	inositol(myo)-1(or 4)-monophosphatase 2, putative	0.0034	0.0015	0.0056
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0012	0.0009
Trypanosoma cruzi	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative	0.2309	1	1
Trypanosoma cruzi	Histidine phosphatase superfamily (branch 1), putative	0.0039	0.0039	0.0027
Trypanosoma cruzi	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative	0.2309	1	1
Trypanosoma brucei	phosphoglycerate mutase protein, putative	0.0039	0.0039	0.0027
Echinococcus granulosus	inositol monophosphatase 1	0.0034	0.0015	0.0011
Toxoplasma gondii	hypothetical protein	0.0185	0.068	1
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0034	0.0015	0.0004
Echinococcus granulosus	uncharacterized sodium dependent transporter	0.0185	0.068	0.0675
Schistosoma mansoni	sodium-dependent neurotransmitter transporter	0.0185	0.068	0.0675
Toxoplasma gondii	hypothetical protein	0.0185	0.068	1
Plasmodium vivax	phosphoglucomutase-2, putative	0.0039	0.0039	0.0407
Mycobacterium tuberculosis	Possible hydrolase MutT1	0.0039	0.0039	0.0495
Mycobacterium ulcerans	acid phosphatase	0.0039	0.0039	0.0047
Schistosoma mansoni	hypothetical protein	0.0039	0.0039	0.0034
Brugia malayi	phosphoglycerate mutase family protein	0.0039	0.0039	0.0073
Brugia malayi	UBASH3A protein homolog	0.0039	0.0039	0.0073
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0039	0.0037
Trypanosoma cruzi	phosphoglycerate mutase, putative	0.0039	0.0039	0.0027
Onchocerca volvulus	Protein UBASH3A homolog	0.0039	0.0039	0.0034
Schistosoma mansoni	hypothetical protein	0.0039	0.0039	0.0034
Entamoeba histolytica	phosphoglycerate mutase family protein, putative	0.0039	0.0039	0.004
Trypanosoma cruzi	Histidine phosphatase superfamily (branch 1), putative	0.0039	0.0039	0.0027
Leishmania major	phosphoglycerate mutase protein, putative	0.0039	0.0039	0.0027
Echinococcus granulosus	sodium and chloride dependent glycine	0.0185	0.068	0.0675
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0012	0.0009
Trypanosoma brucei	phosphoglycerate mutase, putative	0.0039	0.0039	0.0027
Brugia malayi	beta-lactamase family protein	0.0033	0.0012	0.0015
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0033	0.0012	0.0149
Trypanosoma brucei	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative	0.0985	0.4191	0.4184
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0039	0.0039	0.0495
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0034	0.0015	0.0004
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0012	0.0009
Mycobacterium tuberculosis	Probable lipase LipE	0.0033	0.0012	0.0149
Mycobacterium leprae	conserved hypothetical protein	0.0039	0.0039	1
Trypanosoma cruzi	6-phosphofructo-2-kinase 1	0.227	0.9829	0.9829
Leishmania major	glycerolphosphate mutase, putative	0.0039	0.0039	0.0027
Trichomonas vaginalis	phosphoglycerate mutase, putative	0.0039	0.0039	0.3738
Echinococcus multilocularis	phosphoglycerate mutase	0.0039	0.0039	0.0034
Mycobacterium ulcerans	phosphoglyceromutase	0.0039	0.0039	0.0047
Loa Loa (eye worm)	phosphoglycerate mutase	0.0039	0.0039	0.0037
Mycobacterium tuberculosis	Probable conserved lipoprotein LpqD	0.0039	0.0039	0.0495
Loa Loa (eye worm)	hypothetical protein	0.0185	0.068	0.0677
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0031	0.0005	0.0003
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0185	0.068	0.1453
Schistosoma mansoni	sodium-dependent neurotransmitter transporter	0.0185	0.068	0.0675
Loa Loa (eye worm)	hypothetical protein	0.2309	1	1
Leishmania major	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase-1-like protein	0.0985	0.4191	0.4184
Mycobacterium tuberculosis	Conserved protein	0.0033	0.0012	0.0149
Mycobacterium leprae	conserved hypothetical protein	0.0039	0.0039	1
Schistosoma mansoni	phosphoglycerate mutase	0.0039	0.0039	0.0034
Toxoplasma gondii	Sodium:neurotransmitter symporter family protein	0.0185	0.068	1
Onchocerca volvulus		0.0033	0.0012	0.0007
Plasmodium falciparum	histone acetyltransferase GCN5	0.0045	0.0066	0.0429
Mycobacterium ulcerans	hypothetical protein	0.0039	0.0039	0.0047
Wolbachia endosymbiont of Brugia malayi	fructose-1,6-bisphosphatase	0.0034	0.0015	0.5
Trypanosoma brucei	inositol-1(or 4)-monophosphatase 1, putative	0.0034	0.0015	0.0004
Onchocerca volvulus		0.0033	0.0012	0.0007
Echinococcus granulosus	phosphoglycerate mutase	0.0039	0.0039	0.0034
Plasmodium falciparum	transporter, putative	0.0185	0.068	1
Loa Loa (eye worm)	norepinephrine transporter	0.109	0.465	0.4649
Loa Loa (eye worm)	hypothetical protein	0.0185	0.068	0.0677
Schistosoma mansoni	inositol monophosphatase	0.0034	0.0015	0.0011
Trypanosoma cruzi	phosphoglycerate mutase, putative	0.0039	0.0039	0.0027
Schistosoma mansoni	inositol monophosphatase	0.0034	0.0015	0.0011
Schistosoma mansoni	hypothetical protein	0.0039	0.0039	0.0034
Echinococcus multilocularis	phosphoglycerate mutase	0.0039	0.0039	0.0034
Schistosoma mansoni	hypothetical protein	0.0039	0.0039	0.0034
Toxoplasma gondii	phosphoglycerate mutase family protein	0.0039	0.0039	0.0407
Chlamydia trachomatis	Ssodium-dependent amino acid transporter	0.0185	0.068	1
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0209	0.0787	1
Loa Loa (eye worm)	inositol-1	0.0034	0.0015	0.0013
Schistosoma mansoni	6-phosphofructokinase	0.2309	1	1
Echinococcus multilocularis	inositol monophosphatase 1	0.0034	0.0015	0.0011
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.0185	0.068	0.0675
Entamoeba histolytica	phosphoglycerate mutase family protein, putative	0.1363	0.5848	1
Leishmania major	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative	0.227	0.9829	0.9829
Brugia malayi	acetyltransferase, GNAT family protein	0.0168	0.0604	0.129
Onchocerca volvulus		0.0039	0.0039	0.0034
Echinococcus granulosus	sodium and chloride dependent glycine	0.0185	0.068	0.0675
Mycobacterium tuberculosis	Probable hydrolase	0.0033	0.0012	0.0149
Leishmania major	hypothetical protein, unknown function	0.0039	0.0039	0.0027
Schistosoma mansoni	phosphoglycerate mutase	0.0039	0.0039	0.0034
Loa Loa (eye worm)	hypothetical protein	0.109	0.465	0.4649
Loa Loa (eye worm)	hypothetical protein	0.0185	0.068	0.0677
Schistosoma mansoni	sodium-dependent amino acid transporter	0.0185	0.068	0.0675
Trichomonas vaginalis	phosphoglycerate mutase, putative	0.0039	0.0039	0.3738
Trichomonas vaginalis	phosphoglycerate mutase, putative	0.0039	0.0039	0.3738
Leishmania major	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0034	0.0015	0.0004
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0039	0.0037
Mycobacterium leprae	probable isochorismate synthase EntC	0.0039	0.0039	1
Echinococcus granulosus	serine:threonine protein phosphatase PGAM5	0.0039	0.0039	0.0034
Trichomonas vaginalis	cat eye syndrome critical region protein 2, cscr2, putative	0.0049	0.0084	1
Echinococcus granulosus	phosphoglycerate mutase	0.0039	0.0039	0.0034
Loa Loa (eye worm)	hypothetical protein	0.227	0.9829	0.9829
Trichomonas vaginalis	conserved hypothetical protein	0.0039	0.0039	0.3738
Mycobacterium leprae	conserved hypothetical protein	0.0039	0.0039	1
Trypanosoma cruzi	phosphoglycerate mutase protein, putative	0.0039	0.0039	0.0027
Mycobacterium leprae	Probable phosphoglycerate mutase (phosphoglyceromutase) (phosphoglycerate phosphomutase)	0.0039	0.0039	1
Echinococcus multilocularis	phosphoglycerate mutase	0.0039	0.0039	0.0034
Trypanosoma brucei	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatas, putative	0.0039	0.0039	0.0027
Trypanosoma brucei	glycerolphosphate mutase, putative	0.0039	0.0039	0.0027
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0049	0.0084	1
Trichomonas vaginalis	phosphoglycerate mutase, putative	0.0039	0.0039	0.3738
Trypanosoma brucei	Histidine phosphatase superfamily (branch 1), putative	0.0039	0.0039	0.0027
Echinococcus granulosus	phosphoglycerate mutase	0.0039	0.0039	0.0034
Leishmania major	hypothetical protein, conserved	0.0039	0.0039	0.0027
Giardia lamblia	Hypothetical protein	0.1363	0.5848	1
Loa Loa (eye worm)	serotonin transporter b	0.109	0.465	0.4649
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.109	0.465	0.4647
Echinococcus multilocularis	sodium:chloride dependent neurotransmitter	0.0185	0.068	0.0675
Plasmodium vivax	histone acetyltransferase GCN5, putative	0.0049	0.0084	0.1089
Onchocerca volvulus	Protein UBASH3A homolog	0.0039	0.0039	0.0034
Mycobacterium leprae	conserved hypothetical protein	0.0033	0.0012	0.3018
Trypanosoma cruzi	glycerolphosphate mutase, putative	0.0039	0.0039	0.0027
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0033	0.0012	0.0007
Loa Loa (eye worm)	hypothetical protein	0.1324	0.5677	0.5676
Mycobacterium leprae	POSSIBLE HYDROLASE MUTT1	0.0039	0.0039	1
Entamoeba histolytica	phosphoglycerate mutase family protein. putative	0.0039	0.0039	0.004
Loa Loa (eye worm)	Sodium:neurotransmitter symporter family protein	0.0185	0.068	0.0677
Schistosoma mansoni	gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2	0.0168	0.0604	0.06
Toxoplasma gondii	phosphoglycerate mutase	0.0039	0.0039	0.0407
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0039	0.0037
Mycobacterium ulcerans	fructose-2,6-bisphosphatase GpmB	0.1363	0.5848	1
Mycobacterium tuberculosis	Glucosyl-3-phosphoglycerate phosphatase GpgP	0.0039	0.0039	0.0495
Schistosoma mansoni	hypothetical protein	0.0039	0.0039	0.0034
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0039	0.0037
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0033	0.0012	0.0007
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0012	0.0009
Echinococcus multilocularis	6 phosphofructo 2 kinase:fructose 2	0.2309	1	1
Loa Loa (eye worm)	hypothetical protein	0.0185	0.068	0.0677
Onchocerca volvulus		0.0039	0.0039	0.0034
Leishmania major	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative	0.2309	1	1
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0163	0.0584	0.0579
Echinococcus multilocularis	gcn5proteinral control of amino acid synthesis	0.0168	0.0604	0.06
Echinococcus granulosus	sodium dependent neurotransmitter transporter	0.0185	0.068	0.0675
Echinococcus multilocularis	sodium and chloride dependent glycine	0.0185	0.068	0.0675
Trypanosoma brucei	Histidine phosphatase superfamily (branch 1), putative	0.0039	0.0039	0.0027
Mycobacterium ulcerans	bifunctional RNase H/acid phosphatase	0.0039	0.0039	0.0047
Schistosoma mansoni	hypothetical protein	0.0039	0.0039	0.0034
Brugia malayi	Inositol-1	0.0034	0.0015	0.0023
Echinococcus granulosus	beta LACTamase domain containing family member	0.0033	0.0012	0.0007
Onchocerca volvulus		0.2309	1	1
Trypanosoma cruzi	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatas, putative	0.0039	0.0039	0.0027
Mycobacterium ulcerans	phosphohistidine phosphatase SixA	0.0039	0.0039	0.0047
Loa Loa (eye worm)	solute carrier family 6 member 4	0.109	0.465	0.4649
Mycobacterium ulcerans	phosphoglycerate mutase	0.0039	0.0039	0.0047
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0185	0.068	0.1453
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0033	0.0012	0.0149
Schistosoma mansoni	sodium/chloride dependent transporter	0.109	0.465	0.4647
Trypanosoma cruzi	6-phosphofructo-2-kinase 1	0.227	0.9829	0.9829
Schistosoma mansoni	sodium-dependent neurotransmitter transporter	0.0185	0.068	0.0675
Loa Loa (eye worm)	Sodium:neurotransmitter symporter family protein	0.0185	0.068	0.0677
Echinococcus multilocularis	serotonin transporter	0.109	0.465	0.4647
Mycobacterium leprae	Probable lipase LipE	0.0033	0.0012	0.3018
Onchocerca volvulus		0.0185	0.068	0.0675
Mycobacterium tuberculosis	Probable lipase LipD	0.0033	0.0012	0.0149
Trypanosoma brucei	6-phosphofructo-2-kinase 2	0.227	0.9829	0.9829
Loa Loa (eye worm)	hypothetical protein	0.109	0.465	0.4649
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.109	0.465	1
Mycobacterium tuberculosis	Probable phosphoglycerate mutase (phosphoglyceromutase) (phosphoglycerate phosphomutase)	0.0039	0.0039	0.0495
Echinococcus granulosus	phosphoglycerate mutase	0.0039	0.0039	0.0034
Trypanosoma cruzi	phosphoglycerate mutase family member 5, putative	0.0039	0.0039	0.0027
Onchocerca volvulus		0.0185	0.068	0.0675
Echinococcus multilocularis	sodium dependent neurotransmitter transporter	0.0185	0.068	0.0675
Mycobacterium ulcerans	hypothetical protein	0.0039	0.0039	0.0047
Mycobacterium leprae	PROBABLE PHOSPHOGLYCERATE MUTASE 1 GPM1 (PHOSPHOGLYCEROMUTASE) (PGAM) (BPG-DEPENDENT PGAM)	0.0039	0.0039	1
Plasmodium falciparum	amino acid transporter, putative	0.0185	0.068	1
Mycobacterium ulcerans	extragenic suppressor protein SuhB	0.0034	0.0015	0.0006
Loa Loa (eye worm)	hypothetical protein	0.109	0.465	0.4649
Toxoplasma gondii	histone lysine acetyltransferase GCN5-B	0.0049	0.0084	0.1089
Onchocerca volvulus		0.109	0.465	0.4647
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	0.0185	0.068	0.0675
Plasmodium vivax	phosphoglycerate mutase, putative	0.0039	0.0039	0.0407
Brugia malayi	hypothetical protein	0.0185	0.068	0.1453
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0012	0.0009
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0033	0.0012	0.0015
Treponema pallidum	sodium- and chloride- dependent transporter	0.109	0.465	1
Trichomonas vaginalis	phosphoglycerate mutase, putative	0.0039	0.0039	0.3738
Leishmania major	phosphoglycerate mutase, putative	0.0039	0.0039	0.0027
Echinococcus granulosus	phosphoglycerate mutase	0.0039	0.0039	0.0034
Onchocerca volvulus		0.0185	0.068	0.0675
Echinococcus granulosus	uncharacterized sodium dependent transporter	0.0185	0.068	0.0675
Mycobacterium ulcerans	phosphoglycerate mutase	0.0039	0.0039	0.0047
Echinococcus granulosus	serine:threonine protein phosphatase PGAM5	0.0039	0.0039	0.0034
Toxoplasma gondii	Sodium:neurotransmitter symporter family protein	0.0185	0.068	1
Loa Loa (eye worm)	hypothetical protein	0.0185	0.068	0.0677
Trypanosoma brucei	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative	0.2309	1	1
Trypanosoma cruzi	glycerolphosphate mutase, putative	0.0039	0.0039	0.0027
Loa Loa (eye worm)	beta-lactamase	0.0033	0.0012	0.0009
Trichomonas vaginalis	inositol monophosphatase, putative	0.0034	0.0015	0.0512
Trypanosoma cruzi	phosphoglycerate mutase family member 5, putative	0.0039	0.0039	0.0027
Onchocerca volvulus	Protein UBASH3A homolog	0.0039	0.0039	0.0034

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL493593

Bibliographic References

No literature references available for this target.

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Detailed information for compound 997420