pI: 5.4569 |
Length (AA): 269 |
MW (Da): 30655 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 5 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
3 | 246 | 1iru (C) | 2 | 251 | 28.00 | 0 | 1 | 1.26 | -0.76 |
4 | 233 | 1iru (F) | 4 | 234 | 44.00 | 0 | 1 | 1.51 | -1.26 |
4 | 240 | 4r3o (F) | 4 | 241 | 42.00 | 0 | 1 | 1.47844 | -0.86 |
4 | 245 | 4r3o (C) | 3 | 250 | 28.00 | 0 | 1 | 1.29303 | -0.62 |
6 | 235 | 1ryp (B) | 5 | 250 | 31.00 | 0 | 1 | 1.21842 | -0.62 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 80-100% percentile | intraerythrocytic - 6 hs, intraerythrocytic - 12 hs, intraerythrocytic - 18 hs, intraerythrocytic - 24 hs, intraerythrocytic - 30 hs. | Zhu L |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 60-80% percentile | intraerythrocytic - 36 hs, intraerythrocytic - 40 hs, intraerythrocytic - 48 hs. | Zhu L |
Zhu L | New insights into the Plasmodium vivax transcriptome using RNA-Seq. |
Ortholog group members (OG5_127884)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT1G47250 | 20S proteasome alpha subunit F2 |
Arabidopsis thaliana | AT5G42790 | proteasome alpha subunit F1 |
Babesia bovis | BBOV_IV000320 | proteasome subunit alpha type 1 |
Brugia malayi | Bm1_26725 | Proteasome subunit alpha type 1 |
Brugia malayi | Bm1_17805 | proteasome subunit alpha type 1 |
Candida albicans | CaO19_7178 | hypothetical protein |
Candida albicans | CaO19.7178 | proteasome alpha-subunit |
Caenorhabditis elegans | CELE_CD4.6 | Protein PAS-6 |
Cryptosporidium hominis | Chro.20222 | proteasome A type subunit |
Cryptosporidium parvum | cgd2_2050 | proteasome subunit alpha type 1, NTN hydrolase |
Dictyostelium discoideum | DDB_G0282363 | 20S proteasome subunit C2 |
Drosophila melanogaster | Dmel_CG4904 | Proteasome alpha6 subunit |
Drosophila melanogaster | Dmel_CG5648 | Proteasome alpha6 subunit, Testis-specific |
Echinococcus granulosus | EgrG_000750500 | 20S proteasome subunit alpha 6 |
Echinococcus granulosus | EgrG_000750600 | cyclin |
Entamoeba histolytica | EHI_086080 | proteasome subunit alpha type 1, putative |
Echinococcus multilocularis | EmuJ_000750500 | 20S proteasome subunit alpha 6 |
Echinococcus multilocularis | EmuJ_000750600 | cyclin |
Giardia lamblia | GL50803_7962 | 20S proteasome alpha subunit 6 |
Homo sapiens | ENSG00000129084 | proteasome (prosome, macropain) subunit, alpha type, 1 |
Leishmania braziliensis | LbrM.35.1750 | proteasome alpha 1 subunit, putative |
Leishmania donovani | LdBPK_361670.1 | proteasome subunit alpha type-1, putative |
Leishmania infantum | LinJ.36.1670 | proteasome alpha 1 subunit, putative |
Leishmania major | LmjF.36.1600 | proteasome alpha 1 subunit, putative |
Leishmania mexicana | LmxM.36.1600 | proteasome alpha 1 subunit, putative |
Loa Loa (eye worm) | LOAG_09359 | proteasome subunit alpha type 1 |
Mus musculus | ENSMUSG00000030751 | proteasome (prosome, macropain) subunit, alpha type 1 |
Neospora caninum | NCLIV_067980 | Proteasome subunit alpha type (EC 3.4.25.1), related |
Oryza sativa | 4328215 | Os02g0133800 |
Plasmodium berghei | PBANKA_1301400 | proteasome subunit alpha type-1, putative |
Plasmodium falciparum | PF3D7_1474800 | proteasome subunit alpha type-1, putative |
Plasmodium knowlesi | PKNH_1245100 | proteasome subunit alpha type-1, putative |
Plasmodium vivax | PVX_118620 | proteasome subunit alpha type-1, putative |
Plasmodium yoelii | PY00267 | proteasome subunit alpha type 1 |
Saccharomyces cerevisiae | YMR314W | proteasome core particle subunit alpha 6 |
Schistosoma japonicum | Sjp_0200730 | ko:K06634 cyclin H, putative |
Schistosoma japonicum | Sjp_0200740 | ko:K02725 20S proteasome subunit alpha 6, putative |
Schistosoma mansoni | Smp_170730 | proteasome subunit alpha 1 (T01 family) |
Schmidtea mediterranea | mk4.006997.01 | Proteasome subunit alpha type-1 |
Schmidtea mediterranea | mk4.004243.00 | CyclinH-like protein |
Schmidtea mediterranea | mk4.004704.00 | Proteasome subunit alpha type-1 |
Schmidtea mediterranea | mk4.006997.00 | Proteasome subunit alpha type-1 |
Trypanosoma brucei gambiense | Tbg972.10.7380 | proteasome alpha 1 subunit, putative,20S proteasome subunit alpha-6, (putative) |
Trypanosoma brucei | Tb11.v5.0196 | Proteasome subunit A N-terminal signature/Proteasome subunit, putative |
Trypanosoma congolense | TcIL3000_10_5090 | proteasome subunit alpha type-1, putative |
Trypanosoma cruzi | TcCLB.506167.40 | proteasome subunit alpha type-1, putative |
Toxoplasma gondii | TGME49_278050 | proteasome subunit alpha type 1, putative |
Theileria parva | TP02_0930 | proteasome subunit alpha type 1, putative |
Theileria parva | TP02_0927 | proteasome subunit alpha type 1, putative |
Trichomonas vaginalis | TVAG_206040 | Family T1, proteasome alpha subunit, threonine peptidase |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.10.6030 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
Tb927.10.6030 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb927.10.6030 | Trypanosoma brucei | significant loss of fitness in procyclic forms | alsford |
Tb927.10.6030 | Trypanosoma brucei | significant loss of fitness in differentiation of procyclic to bloodstream forms | alsford |
CELE_CD4.6 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_CD4.6 | Caenorhabditis elegans | larval arrest | wormbase |
CELE_CD4.6 | Caenorhabditis elegans | larval lethal | wormbase |
CELE_CD4.6 | Caenorhabditis elegans | slow growth | wormbase |
CELE_CD4.6 | Caenorhabditis elegans | sterile | wormbase |
YMR314W | Saccharomyces cerevisiae | inviable | yeastgenome |
PBANKA_1301400 | Plasmodium berghei | Essential | plasmo |
TGME49_278050 | Toxoplasma gondii | Probably essential | sidik |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Species | Known druggable target | Linked compounds | Reference |
---|---|---|---|
Homo sapiens | proteasome (prosome, macropain) subunit, alpha type, 1 | Compounds | References |