pI: 8.8781 |
Length (AA): 216 |
MW (Da): 23325 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
PDB Structures:
Ortholog group members (OG5_127762)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT4G31300 | 20S proteasome subunit PBA1 |
Babesia bovis | BBOV_II005970 | proteosome A, putative |
Brugia malayi | Bm1_51640 | Proteasome A-type and B-type family protein |
Candida albicans | CaO19.6991 | multicatalytic endopeptidase |
Caenorhabditis elegans | CELE_K08D12.1 | Protein PBS-1 |
Cryptosporidium hominis | Chro.20097 | proteasome B type subunit |
Cryptosporidium parvum | cgd2_860 | Pre3p/proteasome regulatory subunit beta type 6, NTN hydrolase fold |
Dictyostelium discoideum | DDB_G0267390 | 20S proteasome subunit beta-6 |
Drosophila melanogaster | Dmel_CG8392 | Proteasome beta1 subunit |
Echinococcus granulosus | EgrG_000230600 | proteasome subunit beta type 6 |
Entamoeba histolytica | EHI_024470 | proteasome subunit beta type 6 precursor, putative |
Echinococcus multilocularis | EmuJ_000230600 | proteasome subunit beta type 6 |
Giardia lamblia | GL50803_9824 | Proteasome subunit beta type 9 precursor |
Homo sapiens | ENSG00000142507 | proteasome (prosome, macropain) subunit, beta type, 6 |
Leishmania braziliensis | LbrM.12.0040 | proteasome beta-1 subunit, putative |
Leishmania donovani | LdBPK_120030.1 | proteasome beta-1 subunit, putative |
Leishmania major | LmjF.12.0030 | proteasome beta-1 subunit, putative |
Leishmania mexicana | LmxM.12.0030 | proteasome beta-1 subunit, putative |
Loa Loa (eye worm) | LOAG_02565 | proteasome A-type and B-type family protein |
Mus musculus | ENSMUSG00000018286 | proteasome (prosome, macropain) subunit, beta type 6 |
Neospora caninum | NCLIV_048880 | Proteasome subunit beta type-7, related |
Oryza sativa | 4330861 | Os02g0770000 |
Oryza sativa | 4340065 | Os06g0139900 |
Plasmodium berghei | PBANKA_0832600 | proteasome subunit beta type-6, putative |
Plasmodium falciparum | PF3D7_0931800 | proteasome subunit beta type-6, putative |
Plasmodium knowlesi | PKNH_0730500 | proteasome subunit beta type-6, putative |
Plasmodium vivax | PVX_087115 | proteasome subunit beta type-6, putative |
Plasmodium yoelii | PY03212 | proteasome beta-subunit, putative |
Saccharomyces cerevisiae | YJL001W | proteasome core particle subunit beta 1 |
Schistosoma japonicum | Sjp_0080900 | ko:K02738 20S proteasome subunit beta 1, putative |
Schistosoma mansoni | Smp_034490 | proteasome catalytic subunit 1 (T01 family) |
Schmidtea mediterranea | mk4.000268.10 | Proteasome subunit beta type |
Trypanosoma brucei gambiense | Tbg972.6.970 | proteasome beta-1 subunit, putative |
Trypanosoma brucei | Tb927.6.1260 | proteasome beta-1 subunit, putative |
Trypanosoma congolense | TcIL3000_6_820 | proteasome beta-1 subunit, putative |
Trypanosoma cruzi | TcCLB.509429.110 | proteasome beta-1 subunit, putative |
Trypanosoma cruzi | TcCLB.507603.40 | proteasome beta-1 subunit, putative |
Toxoplasma gondii | TGME49_223590 | proteasome subunit |
Theileria parva | TP02_0560 | proteasome precursor, putative |
Trichomonas vaginalis | TVAG_127250 | Family T1, proteasome beta subunit, threonine peptidase |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.6.1260 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (3 days) | alsford |
Tb927.6.1260 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb927.6.1260 | Trypanosoma brucei | significant loss of fitness in procyclic forms | alsford |
Tb927.6.1260 | Trypanosoma brucei | significant loss of fitness in differentiation of procyclic to bloodstream forms | alsford |
CELE_K08D12.1 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_K08D12.1 | Caenorhabditis elegans | larval arrest | wormbase |
CELE_K08D12.1 | Caenorhabditis elegans | slow growth | wormbase |
CELE_K08D12.1 | Caenorhabditis elegans | sterile | wormbase |
YJL001W | Saccharomyces cerevisiae | inviable | yeastgenome |
PBANKA_0832600 | Plasmodium berghei | Slow | plasmo |
TGME49_223590 | Toxoplasma gondii | Essentiality uncertain | sidik |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Species | Known druggable target | Linked compounds | Reference |
---|---|---|---|
Homo sapiens | proteasome (prosome, macropain) subunit, beta type, 6 | Compounds | References |