pI: 8.689 |
Length (AA): 414 |
MW (Da): 45574 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 5 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
20 | 403 | 1kbi (B) | 108 | 480 | 33.00 | 0 | 1 | 1.22274 | -0.06 |
31 | 403 | 6gmc (A) | 2 | 362 | 34.00 | 0 | 1 | 1.35987 | -0.69 |
32 | 401 | 6bfg (A) | 3 | 372 | 38.00 | 0 | 1 | 1.40552 | -0.6 |
34 | 402 | 6dvh (A) | 23 | 390 | 31.00 | 0 | 1 | 1.3372 | -0.66 |
95 | 389 | 2cdh (0) | 64 | 342 | 41.00 | 0 | 1 | 0.76936 | 1.25 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_126945)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT3G14150 | Aldolase-type TIM barrel family protein |
Arabidopsis thaliana | AT3G14420 | peroxisomal (S)-2-hydroxy-acid oxidase GLO1 |
Arabidopsis thaliana | AT3G14415 | peroxisomal (S)-2-hydroxy-acid oxidase GLO2 |
Arabidopsis thaliana | AT3G14130 | Aldolase-type TIM barrel family protein |
Candida albicans | CaO19.12467 | cytochrome b2 precursor |
Candida albicans | CaO19.5000 | cytochrome b2 precursor |
Caenorhabditis elegans | CELE_F41E6.5 | Protein F41E6.5, isoform A |
Dictyostelium discoideum | DDB_G0291814 | hydroxyacid oxidase |
Drosophila melanogaster | Dmel_CG18003 | CG18003 gene product from transcript CG18003-RB |
Escherichia coli | b3605 | L-lactate dehydrogenase, FMN-linked |
Homo sapiens | ENSG00000116882 | hydroxyacid oxidase 2 (long chain) |
Homo sapiens | ENSG00000101323 | hydroxyacid oxidase (glycolate oxidase) 1 |
Mycobacterium leprae | ML2046 | POSSIBLE L-LACTATE DEHYDROGENASE (CYTOCHROME) LLDD2 |
Mus musculus | ENSMUSG00000027261 | hydroxyacid oxidase 1, liver |
Mus musculus | ENSMUSG00000027870 | hydroxyacid oxidase 2 |
Mycobacterium tuberculosis | Rv1872c | Possible L-lactate dehydrogenase (cytochrome) LldD2 |
Mycobacterium ulcerans | MUL_3002 | L-lactate dehydrogenase (cytochrome) LldD2 |
Oryza sativa | 9266434 | Os08g0198700 |
Oryza sativa | 4337048 | Os04g0623500 |
Oryza sativa | 4343908 | Os07g0616500 |
Oryza sativa | 9266366 | Os04g0623600 |
Oryza sativa | 4334349 | Os03g0786100 |
Oryza sativa | 4342420 | Os07g0152900 |
Saccharomyces cerevisiae | YML054C | Cyb2p |
Schmidtea mediterranea | mk4.009795.02 | |
Schmidtea mediterranea | mk4.009795.01 | |
Treponema pallidum | TP0291 | hypothetical protein |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
mtu1902 | Mycobacterium tuberculosis | non-essential | nmpdr |
b3605 | Escherichia coli | non-essential | goodall |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Species | Known druggable target | Linked compounds | Reference |
---|---|---|---|
Homo sapiens | hydroxyacid oxidase 2 (long chain) | Compounds | References |
Rattus norvegicus | Hydroxyacid oxidase 2 | Compounds | References |
Homo sapiens | hydroxyacid oxidase (glycolate oxidase) 1 | Compounds | References |