Detailed information for compound 207175

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 401.264 | Formula: C20H15Cl2FN4--
  • H donors: 1 H acceptors: 3 LogP: 5.65 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: Fc1ccc2c(c1)nc(nc2NCc1ccccc1)c1cccnc1.[Cl-].[Cl-]
  • InChi: 1S/C20H15FN4.2ClH/c21-16-8-9-17-18(11-16)24-19(15-7-4-10-22-13-15)25-20(17)23-12-14-5-2-1-3-6-14;;/h1-11,13H,12H2,(H,23,24,25);2*1H/p-2
  • InChiKey: IDIMEDVIQMTXHX-UHFFFAOYSA-L  


Substructure search Similarity search

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0057 0.0561 0.1038
Loa Loa (eye worm) hypothetical protein 0.0074 0.0773 0.186
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0022 0.0115 0.0444
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.0076 0.0147
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0097 0.1073 0.2001
Plasmodium falciparum histone acetyltransferase GCN5 0.0038 0.0321 0.3341
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0076 0.0147
Onchocerca volvulus 0.0042 0.0365 0.0981
Mycobacterium tuberculosis Probable dehydrogenase 0.0084 0.0898 0.1583
Echinococcus multilocularis neuropeptide s receptor 0.0426 0.5263 0.5252
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0074 0.077 0.2225
Schistosoma mansoni mixed-lineage leukemia protein mll 0.012 0.1366 0.2596
Plasmodium falciparum flap endonuclease 1 0.0088 0.0947 1
Entamoeba histolytica exonuclease, putative 0.0026 0.0163 0.0589
Plasmodium vivax glutathione reductase, putative 0.0037 0.0299 0.3107
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0076 0.0109
Mycobacterium leprae Probable lipase LipE 0.0067 0.0682 0.1222
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0035 0.0279 0.0486
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0074 0.077 0.2225
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0035 0.0282 0.1915
Echinococcus multilocularis neuropeptide receptor A26 0.0426 0.5263 0.5252
Schistosoma mansoni flap endonuclease-1 0.0075 0.079 0.1482
Plasmodium falciparum DNA repair protein RAD2, putative 0.0076 0.0803 0.8462
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0074 0.077 0.2225
Schistosoma mansoni hypothetical protein 0.0076 0.08 0.1501
Brugia malayi Thioredoxin reductase 0.0037 0.0299 0.0893
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0074 0.077 0.2225
Schistosoma mansoni hypothetical protein 0.0016 0.0034 0.0019
Loa Loa (eye worm) hypothetical protein 0.003 0.0217 0.0439
Trypanosoma brucei ISWI complex protein 0.0016 0.0034 0.0066
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0057 0.0561 0.3459
Plasmodium falciparum plasmepsin I 0.0017 0.0045 0.0417
Loa Loa (eye worm) transcription factor SMAD2 0.011 0.1228 0.3026
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0074 0.077 0.2225
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0088 0.0947 1
Leishmania major isopentenyl-diphosphate delta-isomerase, putative,isomerase, putative 0.0135 0.1556 1
Trichomonas vaginalis D-aminoacylase, putative 0.0067 0.0682 0.1955
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0076 0.0458
Trichomonas vaginalis ap endonuclease, putative 0.0037 0.0298 0.0777
Loa Loa (eye worm) hypothetical protein 0.0019 0.0076 0.0079
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.0033 0.0245 0.0705
Echinococcus granulosus GTP binding nuclear protein Ran 0.0022 0.0115 0.0173
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0067 0.0682 0.1166
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0076 0.0099
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0074 0.077 0.2225
Echinococcus granulosus tar DNA binding protein 0.0068 0.0695 0.128
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0069 0.0711 0.1311
Loa Loa (eye worm) hypothetical protein 0.0067 0.0682 0.1628
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0017 0.0045 0.004
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0057 0.0561 0.106
Trypanosoma cruzi DNA repair protein RAD2, putative 0.0026 0.0163 0.1413
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0033 0.0245 0.0614
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0084 0.0898 0.1583
Trypanosoma cruzi DNA repair and recombination helicase protein PIF6, putative 0.0062 0.0621 0.6423
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0017 0.0045 0.004
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0217 0.0418
Mycobacterium tuberculosis Two component sensor histidine kinase DevS 0.0023 0.013 0.0103
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0074 0.077 0.2225
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.0076 0.0458
Schistosoma mansoni zinc finger protein 0.0027 0.0177 0.0295
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0239 0.2882 0.7257
Echinococcus granulosus GPCR family 2 0.0035 0.0279 0.0486
Loa Loa (eye worm) hypothetical protein 0.0156 0.1819 0.4539
Echinococcus multilocularis GPCR, family 2 0.0035 0.0279 0.0255
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0033 0.0245 0.0614
Entamoeba histolytica hypothetical protein, conserved 0.0062 0.0621 0.368
Schistosoma mansoni ran 0.0022 0.0115 0.0175
Entamoeba histolytica isopentenyl-diphosphate delta-isomerase, putative 0.0135 0.1556 1
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0074 0.077 0.2225
Schistosoma mansoni cathepsin D (A01 family) 0.0017 0.0045 0.004
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0111 0.1249 0.4242
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0038 0.0309 0.0543
Trichomonas vaginalis exonuclease%2C+putative 0.0026 0.0163 0.0362
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0074 0.077 0.2225
Mycobacterium ulcerans beta-lactamase 0.0067 0.0682 0.1325
Echinococcus granulosus fetal alzheimer antigen falz 0.0027 0.0172 0.0281
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0276 0.0252
Mycobacterium tuberculosis Probable hydrolase 0.0067 0.0682 0.1166
Brugia malayi latrophilin 2 splice variant baaae 0.0076 0.08 0.266
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0084 0.0898 0.1701
Onchocerca volvulus 0.0035 0.0282 0.0726
Trichomonas vaginalis ran, putative 0.0022 0.0115 0.0213
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0276 0.0486
Trypanosoma cruzi hypothetical protein, conserved 0.0026 0.0163 0.1413
Echinococcus granulosus histone acetyltransferase KAT2B 0.0044 0.0397 0.071
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0074 0.077 0.2225
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0067 0.0682 0.1273
Trypanosoma brucei DNA repair and recombination helicase protein PIF7 0.0062 0.0621 0.1196
Loa Loa (eye worm) flap endonuclease-1 0.0088 0.0947 0.2308
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0037 0.0298 0.0428
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0076 0.0052
Giardia lamblia Exonuclease 1 0.0026 0.0163 0.1001
Loa Loa (eye worm) TAR-binding protein 0.0068 0.0695 0.1662
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0033 0.0245 0.0705
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0097 0.1073 0.2029
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0076 0.0095
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0035 0.0282 0.0498
Schistosoma mansoni survival motor neuron protein 0.0042 0.0365 0.0659
Trichomonas vaginalis importin beta-1, putative 0.0025 0.0144 0.0302
Trypanosoma cruzi DNA repair protein RAD2, putative 0.0026 0.0163 0.1413
Echinococcus multilocularis snurportin 1 0.0324 0.3954 0.3939
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.0074 0.077 0.1443
Schistosoma mansoni tar DNA-binding protein 0.0068 0.0695 0.1298
Echinococcus granulosus flap endonuclease GEN 1 0.0026 0.0163 0.0265
Echinococcus multilocularis survival motor neuron protein 1 0.0205 0.2449 0.2431
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0044 0.0397 0.4149
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0017 0.0045 0.004
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0027 0.0172 0.0285
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0145 0.168 0.3205
Leishmania major GTP-binding protein, putative 0.0022 0.0115 0.0529
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0088 0.0947 0.1826
Brugia malayi hypothetical protein 0.0205 0.2449 0.8474
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0074 0.077 0.2225
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0217 0.0418
Loa Loa (eye worm) hypothetical protein 0.0067 0.0682 0.1628
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0074 0.077 0.2225
Schistosoma mansoni methyl-cpg binding protein mbd 0.0018 0.0058 0.0064
Schistosoma mansoni hypothetical protein 0.0324 0.3954 0.7608
Onchocerca volvulus 0.0067 0.0682 0.1955
Toxoplasma gondii ABC1 family protein 0.0067 0.0682 0.5157
Leishmania major hypothetical protein, conserved 0.0026 0.0163 0.0848
Plasmodium vivax aspartyl proteinase, putative 0.0017 0.0045 0.0417
Trypanosoma brucei hypothetical protein, conserved 0.0067 0.0682 0.1314
Echinococcus multilocularis beta LACTamase domain containing family member 0.0067 0.0682 0.0659
Leishmania major DNA polymerase eta, putative 0.0019 0.0076 0.0275
Brugia malayi XPG N-terminal domain containing protein 0.0062 0.0627 0.2051
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0019 0.0068 0.0083
Trichomonas vaginalis conserved hypothetical protein 0.0065 0.0654 0.187
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0017 0.0045 0.004
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0076 0.0147
Toxoplasma gondii thioredoxin reductase 0.0037 0.0299 0.2052
Schistosoma mansoni ap endonuclease 0.0037 0.0298 0.053
Plasmodium falciparum plasmepsin X 0.0017 0.0045 0.0417
Loa Loa (eye worm) hypothetical protein 0.0046 0.0418 0.0953
Schistosoma mansoni tar DNA-binding protein 0.0068 0.0695 0.1298
Mycobacterium ulcerans L-lactate dehydrogenase (cytochrome) LldD1 0.0135 0.1556 0.3239
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0076 0.01
Plasmodium vivax aspartyl proteinase, putative 0.0017 0.0045 0.0417
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0035 0.0279 0.0486
Schistosoma mansoni ap endonuclease 0.0037 0.0298 0.053
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0057 0.0561 0.106
Brugia malayi glutathione reductase 0.0037 0.0299 0.0893
Schistosoma mansoni xp-G/rad2 DNA repair endonuclease family member 0.0026 0.0163 0.0269
Plasmodium falciparum plasmepsin VII 0.0017 0.0045 0.0417
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0093 0.1017 0.1965
Loa Loa (eye worm) hypothetical protein 0.0067 0.0682 0.1628
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.0033 0.0245 0.0221
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0093 0.1017 0.1812
Leishmania major importin beta-1 subunit, putative 0.0025 0.0144 0.0719
Brugia malayi RNA recognition motif domain containing protein 0.0068 0.0695 0.2291
Plasmodium falciparum plasmepsin VIII, putative 0.0017 0.0045 0.0417
Trichomonas vaginalis conserved hypothetical protein 0.0074 0.077 0.2225
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0037 0.0298 0.289
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0076 0.0147
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0076 0.0147
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0053 0.0509 0.0938
Loa Loa (eye worm) thioredoxin reductase 0.0037 0.0299 0.0648
Mycobacterium tuberculosis Probable lipase LipE 0.0067 0.0682 0.1166
Plasmodium vivax aspartyl protease, putative 0.0017 0.0045 0.0417
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.0033 0.0245 0.0421
Schistosoma mansoni cathepsin D (A01 family) 0.0017 0.0045 0.004
Plasmodium vivax hypothetical protein, conserved 0.0023 0.013 0.1314
Onchocerca volvulus 0.0056 0.0547 0.154
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.0074 0.077 0.2225
Giardia lamblia hypothetical protein 0.0026 0.0163 0.1001
Schistosoma mansoni hypothetical protein 0.0022 0.0105 0.0157
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0017 0.0045 0.004
Schistosoma mansoni hypothetical protein 0.0035 0.0279 0.0493
Loa Loa (eye worm) hypothetical protein 0.0205 0.2449 0.615
Plasmodium falciparum thioredoxin reductase 0.0037 0.0299 0.3107
Echinococcus granulosus importin subunit beta 1 0.003 0.0217 0.0367
Echinococcus granulosus methyl CpG binding domain protein 2 0.0018 0.0058 0.0063
Plasmodium vivax aspartyl protease, putative 0.0017 0.0045 0.0417
Toxoplasma gondii XPG N-terminal domain-containing protein 0.0026 0.0163 0.0956
Schistosoma mansoni zinc finger protein 0.0016 0.0034 0.0019
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0074 0.077 0.1483
Mycobacterium tuberculosis Conserved protein 0.0067 0.0682 0.1166
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0017 0.0045 0.004
Schistosoma mansoni ran 0.0022 0.0115 0.0175
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0076 0.0079
Plasmodium falciparum glutathione reductase 0.0037 0.0299 0.3107
Loa Loa (eye worm) beta-lactamase 0.0067 0.0682 0.1628
Mycobacterium tuberculosis Possible L-lactate dehydrogenase (cytochrome) LldD2 0.0378 0.4645 0.8799
Brugia malayi exodeoxyribonuclease III family protein 0.0037 0.0298 0.0891
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0067 0.0682 0.1166
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0037 0.0298 0.0523
Echinococcus granulosus neuropeptide receptor A26 0.0426 0.5263 1
Echinococcus granulosus thioredoxin glutathione reductase 0.0037 0.0305 0.0535
Brugia malayi hypothetical protein 0.0156 0.1819 0.6254
Loa Loa (eye worm) RNA binding protein 0.0068 0.0695 0.1662
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0093 0.1017 0.1812
Trichomonas vaginalis D-aminoacylase, putative 0.0067 0.0682 0.1955
Trichomonas vaginalis flap endonuclease-1, putative 0.0026 0.0163 0.0362
Schistosoma mansoni cpg binding protein 0.0061 0.0613 0.1139
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0067 0.0682 0.1325
Schistosoma mansoni bromodomain containing protein 0.0073 0.0759 0.1422
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.0074 0.077 0.1422
Plasmodium falciparum plasmepsin V 0.0017 0.0045 0.0417
Entamoeba histolytica hypothetical protein 0.0035 0.0276 0.1348
Entamoeba histolytica hypothetical protein 0.0025 0.0144 0.0457
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0053 0.0509 0.0938
Toxoplasma gondii histone lysine methyltransferase SET1 0.0114 0.1279 1
Plasmodium falciparum plasmepsin IX 0.0017 0.0045 0.0417
Loa Loa (eye worm) hypothetical protein 0.0067 0.0682 0.1628
Trypanosoma brucei DNA repair and recombination helicase protein PIF6 0.0062 0.0621 0.1196
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0076 0.0147
Mycobacterium leprae POSSIBLE L-LACTATE DEHYDROGENASE (CYTOCHROME) LLDD2 0.0378 0.4645 1
Leishmania major trypanothione reductase 0.0037 0.0299 0.1736
Loa Loa (eye worm) hypothetical protein 0.0051 0.0484 0.1122
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0115 0.0882
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0076 0.0458
Plasmodium vivax exonuclease I, putative 0.0026 0.0163 0.1671
Plasmodium falciparum plasmepsin II 0.0017 0.0045 0.0417
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0076 0.0109
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0074 0.077 0.8054
Mycobacterium leprae conserved hypothetical protein 0.0067 0.0682 0.1222
Onchocerca volvulus 0.0067 0.0682 0.1955
Schistosoma mansoni tar DNA-binding protein 0.0068 0.0695 0.1298
Mycobacterium ulcerans esterase/lipase LipP 0.0067 0.0682 0.1325
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0097 0.1073 0.1051
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0069 0.0711 0.0688
Brugia malayi beta-lactamase family protein 0.0067 0.0682 0.2244
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0097 0.1073 0.2029
Echinococcus multilocularis zinc finger protein 0.0027 0.0177 0.0153
Trypanosoma brucei RNA helicase, putative 0.042 0.519 1
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0037 0.0298 0.5
Trichomonas vaginalis D-aminoacylase, putative 0.0067 0.0682 0.1955
Schistosoma mansoni importin beta-1 0.003 0.0217 0.0372
Loa Loa (eye worm) XPG I-region family protein 0.0026 0.0163 0.0302
Mycobacterium ulcerans putative regulatory protein 0.0023 0.013 0.0117
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0018 0.0058 0.0033
Loa Loa (eye worm) hypothetical protein 0.0067 0.0682 0.1628
Schistosoma mansoni exonuclease 0.0026 0.0163 0.0269
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0022 0.0115 0.1156
Brugia malayi Calcitonin receptor-like protein seb-1 0.0111 0.1249 0.4242
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0074 0.077 0.1483
Trichomonas vaginalis set domain proteins, putative 0.0272 0.3301 1
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0074 0.077 0.2225
Loa Loa (eye worm) hypothetical protein 0.0111 0.1249 0.3079
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0017 0.0045 0.004
Loa Loa (eye worm) latrophilin receptor protein 2 0.0035 0.0279 0.0598
Brugia malayi F/Y-rich N-terminus family protein 0.002 0.0091 0.016
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0076 0.0147
Echinococcus granulosus flap endonuclease 1 0.0088 0.0947 0.1762
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0076 0.0275
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0074 0.077 0.2225
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0057 0.0561 0.0933
Schistosoma mansoni xp-G/rad2 DNA repair endonuclease family 0.0076 0.0803 0.1506
Schistosoma mansoni cpg binding protein 0.0061 0.0613 0.1139
Treponema pallidum hypothetical protein 0.0378 0.4645 1
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0076 0.0095
Plasmodium falciparum plasmepsin III 0.0017 0.0045 0.0417
Loa Loa (eye worm) hypothetical protein 0.0067 0.0682 0.1628
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0074 0.077 0.8054
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0038 0.0309 0.0285
Trypanosoma cruzi DNA repair and recombination helicase protein PIF7, putative 0.0062 0.0621 0.6423
Mycobacterium tuberculosis Conserved protein 0.0067 0.0682 0.1166
Echinococcus granulosus histone acetyltransferase KAT2B 0.0139 0.1597 0.3002
Schistosoma mansoni hypothetical protein 0.0035 0.0279 0.0493
Brugia malayi Importin beta-1 subunit 0.003 0.0217 0.0605
Brugia malayi acetyltransferase, GNAT family protein 0.0145 0.168 0.5762
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0076 0.0147
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0076 0.0458
Giardia lamblia Histone acetyltransferase GCN5 0.0038 0.0321 0.2805
Trypanosoma brucei trypanothione reductase 0.0037 0.0299 0.0575
Brugia malayi hypothetical protein 0.0035 0.0276 0.0812
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0068 0.0695 0.1662
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0022 0.0115 0.1156
Trypanosoma brucei exonuclease, putative 0.0026 0.0163 0.0315
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0035 0.0279 0.0255
Echinococcus granulosus histone lysine methyltransferase setb 0.0053 0.0509 0.0924
Echinococcus multilocularis flap endonuclease 1 0.0088 0.0947 0.0925
Echinococcus multilocularis tar DNA binding protein 0.0068 0.0695 0.0672
Loa Loa (eye worm) hypothetical protein 0.004 0.0342 0.0758
Echinococcus granulosus survival motor neuron protein 1 0.0205 0.2449 0.4628
Mycobacterium tuberculosis Probable reductase 0.0084 0.0898 0.1583
Plasmodium vivax plasmepsin IV, putative 0.0017 0.0045 0.0417
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0037 0.0298 0.15
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0037 0.0298 0.289
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0067 0.0682 0.2244
Echinococcus multilocularis importin subunit beta 1 0.003 0.0217 0.0193
Plasmodium vivax hypothetical protein, conserved 0.0067 0.0682 0.7178
Echinococcus granulosus dna polymerase eta 0.0019 0.0076 0.0099
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0035 0.0282 0.0258
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0074 0.077 0.2225
Trichomonas vaginalis conserved hypothetical protein 0.0065 0.0654 0.187
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0019 0.0068 0.0044
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.005 0.0471 0.4777
Schistosoma mansoni DNA polymerase eta 0.0019 0.0076 0.01
Trypanosoma brucei isopentenyl-diphosphate delta-isomerase (type II) 0.0135 0.1556 0.2999
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0074 0.077 0.2225
Schistosoma mansoni hypothetical protein 0.0035 0.0276 0.0486
Trichomonas vaginalis penicillin-binding protein, putative 0.0067 0.0682 0.1955
Entamoeba histolytica DNA-repair protein, putative 0.0076 0.0803 0.4909
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0097 0.1073 0.2628
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0076 0.0147
Schistosoma mansoni hypothetical protein 0.0042 0.0365 0.0659
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0022 0.0115 0.0178
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0074 0.077 0.2225
Echinococcus granulosus beta LACTamase domain containing family member 0.0067 0.0682 0.1255
Toxoplasma gondii hypothetical protein 0.0065 0.0654 0.4934
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0076 0.0052
Plasmodium vivax plasmepsin V, putative 0.0017 0.0045 0.0417
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.013 0.0259
Brugia malayi RNA binding protein 0.0068 0.0695 0.2291
Trichomonas vaginalis esterase, putative 0.0067 0.0682 0.1955
Toxoplasma gondii exonuclease III APE 0.0037 0.0298 0.2049
Loa Loa (eye worm) acetyltransferase 0.0145 0.168 0.4181
Trichomonas vaginalis flap endonuclease-1, putative 0.0026 0.0163 0.0362
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0022 0.0115 0.0245
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.0033 0.0245 0.0427
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0044 0.0397 0.2847
Leishmania major PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative 0.0062 0.0621 0.3854
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0097 0.1073 0.3622
Trichomonas vaginalis flap endonuclease-1, putative 0.0088 0.0947 0.277
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0074 0.077 0.8054
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0084 0.0898 0.1583
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0076 0.0147
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0037 0.0298 0.0274
Mycobacterium ulcerans lipase LipD 0.0067 0.0682 0.1325
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0144 0.0302
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0035 0.0282 0.0498
Trypanosoma cruzi importin beta-1 subunit, putative 0.0025 0.0144 0.1199
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0097 0.1073 0.2001
Brugia malayi TAR-binding protein 0.0068 0.0695 0.2291
Entamoeba histolytica exonuclease, putative 0.0026 0.0163 0.0589
Brugia malayi CXXC zinc finger family protein 0.0056 0.0547 0.1767
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0017 0.0045 0.004
Loa Loa (eye worm) hypothetical protein 0.0033 0.0245 0.0511
Echinococcus granulosus dna polymerase kappa 0.0019 0.0076 0.0099
Loa Loa (eye worm) PHD-finger family protein 0.0022 0.0105 0.0154
Loa Loa (eye worm) MH2 domain-containing protein 0.011 0.1228 0.3026
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0033 0.025 0.043
Entamoeba histolytica Ran family GTPase 0.0022 0.0115 0.0261
Toxoplasma gondii XPG N-terminal domain-containing protein 0.0026 0.0163 0.0956
Trichomonas vaginalis conserved hypothetical protein 0.0065 0.0654 0.187
Echinococcus granulosus cathepsin d lysosomal aspartyl protease 0.0017 0.0045 0.004
Echinococcus multilocularis thioredoxin glutathione reductase 0.0037 0.0305 0.0281
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0076 0.0458
Giardia lamblia Rrm3p helicase 0.0062 0.0621 0.6251
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0074 0.077 0.2225
Echinococcus granulosus snurportin 1 0.0324 0.3954 0.7501
Brugia malayi beta-lactamase 0.0067 0.0682 0.2244
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0076 0.01
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0037 0.0298 0.0486
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0067 0.0682 0.1166
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0037 0.0298 0.3104
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0037 0.0298 0.3104
Leishmania major PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative 0.0062 0.0621 0.3854
Brugia malayi Pre-SET motif family protein 0.0239 0.2882 1
Echinococcus multilocularis ATP dependent DNA helicase PIF1 0.0062 0.0621 0.0598
Brugia malayi Latrophilin receptor protein 2 0.0035 0.0279 0.0825
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0115 0.0882
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0017 0.0045 0.004
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0427 0.5269 1
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0037 0.0298 0.0647
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0145 0.168 0.1659
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0057 0.0561 0.1024
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0057 0.0561 0.0538
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.005 0.0471 0.1306
Brugia malayi XPG I-region family protein 0.0026 0.0163 0.0416
Loa Loa (eye worm) hypothetical protein 0.0026 0.0163 0.0302
Loa Loa (eye worm) histone methyltransferase 0.0019 0.0068 0.0058
Leishmania major DNA polymerase kappa, putative 0.0019 0.0076 0.0275
Echinococcus multilocularis cpg binding protein 0.0061 0.0613 0.059
Plasmodium falciparum GAF domain-related protein, putative 0.0023 0.013 0.1314
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0074 0.077 0.2225
Brugia malayi RNA, U transporter 1 0.0086 0.0929 0.3115
Giardia lamblia Flap structure-specific endonuclease 0.0088 0.0947 1
Echinococcus multilocularis cathepsin d (lysosomal aspartyl protease) 0.0017 0.0045 0.0021
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0057 0.0561 0.1817
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0074 0.077 0.2225
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0144 0.0302
Entamoeba histolytica hypothetical protein 0.0035 0.0276 0.1348
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0111 0.1249 0.3079
Mycobacterium ulcerans two component sensor histidine kinase DevS 0.0023 0.013 0.0117
Schistosoma mansoni hypothetical protein 0.0062 0.0621 0.1154
Loa Loa (eye worm) hypothetical protein 0.0076 0.0803 0.1937
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0027 0.0172 0.0148
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0022 0.0115 0.0091
Mycobacterium tuberculosis Probable lipase LipD 0.0067 0.0682 0.1166
Plasmodium falciparum plasmepsin IV 0.0017 0.0045 0.0417
Schistosoma mansoni hypothetical protein 0.042 0.519 1
Plasmodium vivax thioredoxin reductase, putative 0.0037 0.0299 0.3107
Toxoplasma gondii HEAT repeat-containing protein 0.003 0.0217 0.139
Trypanosoma brucei unspecified product 0.0019 0.0076 0.0147
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0067 0.0682 0.1628
Leishmania major hypothetical protein, conserved 0.0067 0.0682 0.4254
Trichomonas vaginalis flap endonuclease-1, putative 0.0076 0.0803 0.2326
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0037 0.0298 0.2549
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0076 0.0147
Trypanosoma cruzi hypothetical protein, conserved 0.0067 0.0682 0.7091
Plasmodium falciparum importin beta, putative 0.003 0.0217 0.2239
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0022 0.0115 0.0221
Toxoplasma gondii hypothetical protein 0.0023 0.013 0.0684
Brugia malayi Bromodomain containing protein 0.0085 0.0915 0.3065
Mycobacterium ulcerans hypothetical protein 0.0067 0.0682 0.1325
Trichomonas vaginalis bromodomain-containing protein, putative 0.0044 0.0397 0.1079
Loa Loa (eye worm) glutathione reductase 0.0037 0.0299 0.0648
Loa Loa (eye worm) hypothetical protein 0.0076 0.08 0.1931
Loa Loa (eye worm) follicle stimulating hormone receptor 0.023 0.2763 0.6953
Echinococcus multilocularis exonuclease 1 0.0026 0.0163 0.0139
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0074 0.077 0.2225
Mycobacterium ulcerans putative regulatory protein 0.0023 0.013 0.0117
Schistosoma mansoni cpg binding protein 0.0056 0.0547 0.1011
Plasmodium vivax DNA repair protein RAD2, putative 0.0076 0.0803 0.8462
Onchocerca volvulus 0.0156 0.1819 0.5448
Trypanosoma cruzi DNA repair and recombination helicase protein PIF7, putative 0.0062 0.0621 0.6423
Trypanosoma cruzi hypothetical protein, conserved 0.0067 0.0682 0.7091
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0037 0.0298 0.1734
Brugia malayi beta-lactamase family protein 0.0067 0.0682 0.2244
Entamoeba histolytica acetyltransferase, GNAT family 0.0038 0.0321 0.1651
Trichomonas vaginalis flap endonuclease-1, putative 0.0026 0.0163 0.0362
Entamoeba histolytica hypothetical protein 0.0035 0.0276 0.1348
Schistosoma mansoni tar DNA-binding protein 0.0068 0.0695 0.1298
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0088 0.0947 0.731
Brugia malayi PHD-finger family protein 0.0033 0.0248 0.0713
Plasmodium vivax importin-beta 2, putative 0.003 0.0217 0.2239
Mycobacterium tuberculosis Probable esterase LipL 0.0067 0.0682 0.1166
Echinococcus granulosus cpg binding protein 0.0061 0.0613 0.1123
Loa Loa (eye worm) DEAH box polypeptide 35 0.0035 0.0282 0.0606
Brugia malayi Flap endonuclease-1 0.0088 0.0947 0.318
Mycobacterium ulcerans isopentenyl pyrophosphate isomerase 0.0135 0.1556 0.3239
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0044 0.0397 0.2847
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0022 0.0115 0.0563
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0074 0.077 0.2225
Echinococcus multilocularis dna polymerase eta 0.0019 0.0076 0.0052
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0074 0.077 0.2225
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0035 0.0279 0.0255
Schistosoma mansoni tar DNA-binding protein 0.0068 0.0695 0.1298
Loa Loa (eye worm) hypothetical protein 0.0053 0.0509 0.1186
Onchocerca volvulus 0.0067 0.0682 0.1955
Brugia malayi Bromodomain containing protein 0.0044 0.0385 0.1198
Echinococcus granulosus ATP dependent DNA helicase PIF1 0.0062 0.0621 0.1138
Brugia malayi follicle stimulating hormone receptor 0.023 0.2763 0.9581
Schistosoma mansoni hypothetical protein 0.0035 0.0279 0.0493
Echinococcus granulosus neuropeptide s receptor 0.0426 0.5263 1
Mycobacterium tuberculosis Probable oxidoreductase 0.0093 0.1017 0.1812
Brugia malayi Pre-SET motif family protein 0.0035 0.0282 0.0833
Trichomonas vaginalis ap endonuclease, putative 0.0037 0.0298 0.0777
Schistosoma mansoni hypothetical protein 0.0035 0.0279 0.0493
Echinococcus multilocularis DNA repair protein complementing XP G cells 0.0076 0.0803 0.078
Entamoeba histolytica DNA repair and recombination protein, putative 0.0062 0.0621 0.368
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0037 0.0299 0.0428
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0076 0.0147
Toxoplasma gondii XPG N-terminal domain-containing protein 0.0076 0.0803 0.6137
Loa Loa (eye worm) hypothetical protein 0.0023 0.013 0.0216
Brugia malayi MH2 domain containing protein 0.011 0.1228 0.4169
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0324 0.3954 1
Trichomonas vaginalis conserved hypothetical protein 0.0062 0.0621 0.1767
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0033 0.0245 0.0614
Echinococcus granulosus exonuclease 1 0.0026 0.0163 0.0265
Schistosoma mansoni memapsin-2 (A01 family) 0.042 0.5179 0.9979
Trichomonas vaginalis penicillin-binding protein, putative 0.0067 0.0682 0.1955
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0074 0.077 0.2225
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0097 0.1073 0.1051
Mycobacterium ulcerans L-lactate dehydrogenase (cytochrome) LldD2 0.0378 0.4645 1
Plasmodium falciparum plasmepsin VI 0.0017 0.0045 0.0417
Echinococcus granulosus zinc finger protein 0.0027 0.0177 0.029
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0067 0.0682 0.1273
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0044 0.0397 0.1079
Plasmodium vivax SET domain protein, putative 0.0035 0.0282 0.2927
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0088 0.0947 0.6
Loa Loa (eye worm) CXXC zinc finger family protein 0.0056 0.0547 0.1283
Mycobacterium tuberculosis Conserved protein 0.0067 0.0682 0.1166
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0074 0.077 0.2225
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0053 0.0512 0.1193
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0074 0.077 0.2225
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0037 0.0298 0.0575
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.0074 0.077 0.0747
Loa Loa (eye worm) hypothetical protein 0.0035 0.0279 0.0598
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0097 0.1073 0.2029
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0084 0.0898 0.1583
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0074 0.077 0.2225
Trypanosoma cruzi trypanothione reductase, putative 0.0037 0.0299 0.2894
Echinococcus granulosus DNA repair protein complementing XP G cells 0.0076 0.0803 0.1485
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0076 0.0147
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0276 0.0479
Loa Loa (eye worm) bromodomain containing protein 0.0022 0.011 0.0166
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.005 0.0471 0.1306
Mycobacterium tuberculosis Two component sensor histidine kinase DosT 0.0023 0.013 0.0103
Entamoeba histolytica hypothetical protein 0.0035 0.0276 0.1348
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0076 0.0147
Brugia malayi Probable ATP-dependent helicase DHX35 0.0035 0.0282 0.0835
Plasmodium falciparum exonuclease I, putative 0.0026 0.0163 0.1671
Plasmodium vivax flap endonuclease 1, putative 0.0088 0.0947 1
Schistosoma mansoni methyl-cpg binding protein mbd 0.0018 0.0058 0.0064
Toxoplasma gondii hypothetical protein 0.0023 0.013 0.0684
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0042 0.0365 0.1126
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0035 0.0279 0.0825
Trypanosoma brucei DNA repair protein RAD2, putative 0.0026 0.0163 0.0315
Entamoeba histolytica Flap nuclease, putative 0.0088 0.0947 0.5887
Onchocerca volvulus 0.0272 0.3301 1
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0053 0.0509 0.0485
Echinococcus multilocularis flap endonuclease GEN 1 0.0026 0.0163 0.0139
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0084 0.0898 0.1583
Toxoplasma gondii GAF domain-containing protein 0.0023 0.013 0.0684
Loa Loa (eye worm) hypothetical protein 0.0035 0.0282 0.0606
Plasmodium vivax aspartyl protease, putative 0.0017 0.0045 0.0417
Toxoplasma gondii XPG N-terminal domain-containing protein 0.0026 0.0163 0.0956
Trypanosoma cruzi hypothetical protein, conserved 0.0026 0.0163 0.1413

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 0.48 uM Inhibitory activity against phosphodiesterase 5 from human platelets ChEMBL. 7658441

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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