Detailed information for compound 457386

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 356.468 | Formula: C16H16N6S2
  • H donors: 4 H acceptors: 2 LogP: 3.8 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: Nc1ccc2c(c1)sc(n2)NCCNc1nc2c(s1)cc(cc2)N
  • InChi: 1S/C16H16N6S2/c17-9-1-3-11-13(7-9)23-15(21-11)19-5-6-20-16-22-12-4-2-10(18)8-14(12)24-16/h1-4,7-8H,5-6,17-18H2,(H,19,21)(H,20,22)
  • InChiKey: KHTXZHBJGIYHTL-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Pre-SET motif family protein 0.0384 0.405 1
Echinococcus multilocularis lipoxygenase domain containing protein 0.0036 0.0253 0.0372
Schistosoma mansoni rab6-interacting 0.0036 0.0253 0.0253
Treponema pallidum thioredoxin reductase (trxB) 0.0027 0.0148 0.0223
Schistosoma mansoni hypothetical protein 0.0062 0.0534 0.0534
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0025 0.0129 0.0318
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0018 0.0049 0.0005
Entamoeba histolytica disulphide oxidoreductase, putative 0.0027 0.0148 0.036
Leishmania major pyruvate kinase 0.0061 0.0527 0.1611
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0022 0.0091 0.0149
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0025 0.0129 0.0189
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0025 0.0129 0.0189
Loa Loa (eye worm) hypothetical protein 0.0025 0.0129 0.0318
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0112 0.1075 0.1315
Brugia malayi AMP-binding enzyme family protein 0.0039 0.0278 0.0687
Brugia malayi AKH receptor 0.0039 0.0287 0.071
Mycobacterium leprae THIOREDOXIN TRXC (TRX) (MPT46) 0.0027 0.0148 0.0129
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0101 0.0956 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0039 0.0287 0.0423
Echinococcus granulosus GPCR family 2 0.0029 0.017 0.0249
Onchocerca volvulus 0.0039 0.0287 0.0525
Echinococcus granulosus rhodopsin orphan GPCR 0.0039 0.0287 0.0423
Echinococcus granulosus biogenic amine 5HT receptor 0.0039 0.0287 0.0423
Loa Loa (eye worm) pyruvate kinase 0.0061 0.0527 0.1302
Brugia malayi neuropeptide F receptor 0.0039 0.0287 0.071
Plasmodium falciparum thioredoxin reductase 0.029 0.3029 1
Schistosoma mansoni hypothetical protein 0.0055 0.0453 0.0453
Schistosoma mansoni serine/threonine protein kinase 0.0018 0.0049 0.0049
Echinococcus granulosus rhodopsin orphan GPCR 0.0039 0.0287 0.0423
Mycobacterium ulcerans thioredoxin reductase TrxB2 0.0027 0.0148 0.0223
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0192 0.196 0.4014
Loa Loa (eye worm) hypothetical protein 0.0029 0.0171 0.0423
Echinococcus multilocularis g protein coupled receptor 0.0039 0.0287 0.0423
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0527 0.0527
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0269 0.2797 0.6002
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0017 0.0047 0.0012
Echinococcus multilocularis regulator of G protein signaling 3 0.0018 0.0049 0.0072
Loa Loa (eye worm) hypothetical protein 0.0029 0.0171 0.0423
Loa Loa (eye worm) hypothetical protein 0.0113 0.1089 0.2688
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0527 0.0527
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0025 0.0129 0.0189
Echinococcus multilocularis neuropeptides capa receptor 0.0039 0.0287 0.0423
Echinococcus granulosus geminin 0.0156 0.1561 0.2296
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0027 0.0148 0.0221
Mycobacterium ulcerans monoxygenase 0.0027 0.0148 0.0223
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0527 0.0527
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0039 0.0278 0.0496
Schistosoma mansoni hypothetical protein 0.0029 0.017 0.017
Brugia malayi latrophilin 2 splice variant baaae 0.0062 0.0534 0.1317
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0039 0.0287 0.0423
Onchocerca volvulus 0.0025 0.0129 0.0179
Entamoeba histolytica NAD(FAD)-dependent dehydrogenase, putative 0.0027 0.0148 0.036
Echinococcus granulosus regulator of G protein signaling 7 0.0018 0.0049 0.0072
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0662 0.7095 0.8972
Trichomonas vaginalis pyruvate kinase, putative 0.0061 0.0527 0.1049
Loa Loa (eye worm) hypothetical protein 0.0039 0.0287 0.071
Brugia malayi follicle stimulating hormone receptor 0.0039 0.0287 0.071
Loa Loa (eye worm) hypothetical protein 0.0039 0.0287 0.071
Brugia malayi Dopamine receptor protein 2 0.0039 0.0287 0.071
Loa Loa (eye worm) phosphofructokinase 0.0192 0.196 0.4838
Echinococcus granulosus biogenic amine 5HT receptor 0.0039 0.0287 0.0423
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0053 0.0435 0.0639
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0662 0.7095 0.8972
Schistosoma mansoni histamine h1 receptor 0.0039 0.0287 0.0287
Echinococcus granulosus g protein coupled receptor 0.0039 0.0287 0.0423
Echinococcus granulosus orexin receptor type 2 0.0039 0.0287 0.0423
Loa Loa (eye worm) hypothetical protein 0.0039 0.0287 0.071
Echinococcus granulosus lipoxygenase domain containing protein 0.0036 0.0253 0.0372
Entamoeba histolytica phosphofructokinase, putative 0.0192 0.196 0.6953
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0131 0.1293 0.2619
Schistosoma mansoni z-protein (S1r protein) 0.0018 0.0049 0.0049
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0042 0.0316 0.0465
Onchocerca volvulus Huntingtin homolog 0.0113 0.1089 0.2274
Giardia lamblia NADH oxidase lateral transfer candidate 0.0101 0.0956 0.3049
Echinococcus granulosus 6 phosphofructokinase 0.0192 0.196 0.2882
Echinococcus multilocularis sex peptide receptor 0.0039 0.0287 0.0423
Leishmania major 2,4-dienoyl-coa reductase fadh1, putative 0.0027 0.0148 0.0339
Loa Loa (eye worm) G-protein coupled receptor 0.0039 0.0287 0.071
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0027 0.0148 0.0339
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0039 0.0287 0.0423
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0025 0.0129 0.0318
Loa Loa (eye worm) hypothetical protein 0.0039 0.0287 0.071
Loa Loa (eye worm) apoptosis regulator protein 0.0055 0.0453 0.1119
Echinococcus multilocularis neuropeptide Y receptor 0.0039 0.0287 0.0423
Echinococcus multilocularis rhodopsin orphan GPCR 0.0039 0.0287 0.0423
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0017 0.0047 0.0047
Onchocerca volvulus 0.0039 0.0287 0.0525
Schistosoma mansoni apoptosis regulator bax 0.0055 0.0453 0.0453
Brugia malayi 6-phosphofructokinase 0.0192 0.196 0.4838
Loa Loa (eye worm) hypothetical protein 0.0039 0.0287 0.071
Loa Loa (eye worm) latrophilin receptor protein 2 0.0029 0.017 0.0419
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0101 0.0956 0.3047
Brugia malayi hypothetical protein 0.0039 0.0287 0.071
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0025 0.0129 0.0318
Schistosoma mansoni hypothetical protein 0.0055 0.0453 0.0453
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0101 0.0956 0.2359
Brugia malayi nuclear hormone receptor 0.0025 0.0129 0.0318
Entamoeba histolytica acyl-CoA synthetase, putative 0.0039 0.0278 0.0835
Brugia malayi steroid hormone receptor 0.0025 0.0129 0.0318
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0039 0.0278 0.0496
Trypanosoma brucei hypothetical protein, conserved 0.0022 0.0091 0.0149
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0101 0.0956 0.3047
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0056 0.0462 0.1394
Onchocerca volvulus 0.0139 0.1377 0.2902
Brugia malayi Tachykinin-like peptides receptor 99D 0.0039 0.0287 0.071
Schistosoma mansoni axis inhibition protein axin 0.0018 0.0049 0.0049
Echinococcus granulosus TGF beta signal transducer SmadC 0.0014 0.0013 0.002
Schistosoma mansoni glutamate synthase 0.0027 0.0148 0.0148
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0736 0.7902 1
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0025 0.0129 0.0318
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0056 0.0462 0.0462
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0018 0.0049 0.012
Loa Loa (eye worm) hypothetical protein 0.0039 0.0287 0.071
Echinococcus granulosus Polycystic kidney disease protein 0.0036 0.0253 0.0372
Mycobacterium ulcerans beta-lactamase 0.0017 0.0047 0.0012
Brugia malayi Serotonin receptor 0.0039 0.0287 0.071
Onchocerca volvulus 0.0039 0.0287 0.0525
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0662 0.7095 0.8972
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0039 0.0287 0.0287
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0025 0.0129 0.0129
Onchocerca volvulus 0.0046 0.0354 0.067
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0018 0.0049 0.0049
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0027 0.0148 0.0217
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0039 0.0287 0.0287
Plasmodium falciparum type II NADH:ubiquinone oxidoreductase 0.0027 0.0148 0.0193
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0101 0.0956 0.3047
Schistosoma mansoni hypothetical protein 0.0029 0.017 0.017
Mycobacterium ulcerans NADH dehydrogenase Ndh 0.0027 0.0148 0.0223
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0101 0.0956 0.3047
Echinococcus granulosus RUN 0.0036 0.0253 0.0372
Mycobacterium ulcerans acyl-CoA synthetase 0.0039 0.0278 0.0496
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0039 0.0287 0.071
Onchocerca volvulus Pyruvate kinase homolog 0.0061 0.0527 0.1049
Trypanosoma cruzi trypanothione reductase, putative 0.0101 0.0956 0.3047
Loa Loa (eye worm) thioredoxin reductase 0.029 0.3029 0.7479
Loa Loa (eye worm) hypothetical protein 0.0039 0.0287 0.071
Mycobacterium tuberculosis Conserved protein 0.0017 0.0047 0.0007
Brugia malayi Pyruvate kinase, alpha/beta domain containing protein 0.0019 0.0059 0.0146
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0131 0.1293 0.1586
Toxoplasma gondii non-proton pumping type-II NADH dehydrogenase I 0.0027 0.0148 0.0339
Loa Loa (eye worm) hypothetical protein 0.0039 0.0287 0.071
Schistosoma mansoni lipoxygenase 0.0159 0.1598 0.1598
Brugia malayi hypothetical protein 0.0018 0.0049 0.012
Leishmania major hypothetical protein, conserved 0.0027 0.0148 0.0339
Mycobacterium ulcerans hypothetical protein 0.0039 0.0278 0.0496
Trichomonas vaginalis apoptosis inducing factor, putative 0.0027 0.0148 0.0221
Loa Loa (eye worm) hypothetical protein 0.0018 0.0049 0.012
Leishmania major isopentenyl-diphosphate delta-isomerase, putative,isomerase, putative 0.0163 0.1635 0.5326
Echinococcus granulosus tachykinin peptides receptor 99D 0.0039 0.0287 0.0423
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0101 0.0956 0.3047
Loa Loa (eye worm) hypothetical protein 0.0018 0.0049 0.012
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0027 0.0148 0.0221
Schistosoma mansoni 6-phosphofructokinase 0.0192 0.196 0.196
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0039 0.0287 0.0423
Entamoeba histolytica acyl-CoA synthetase, putative 0.0039 0.0278 0.0835
Echinococcus granulosus pyruvate kinase 0.0061 0.0527 0.0775
Giardia lamblia Pyruvate kinase 0.0061 0.0527 0.1432
Brugia malayi TAR-binding protein 0.0061 0.0527 0.1301
Schistosoma mansoni regulator of G protein signaling 0.0018 0.0049 0.0049
Trichomonas vaginalis phosphofructokinase, putative 0.0052 0.0424 0.0824
Echinococcus granulosus microtubule associated protein 2 0.0635 0.68 1
Echinococcus multilocularis g protein coupled receptor 0.0039 0.0287 0.0423
Brugia malayi AMP-binding enzyme family protein 0.0039 0.0278 0.0687
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0029 0.017 0.0419
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0052 0.0424 0.1266
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0018 0.0049 0.0072
Echinococcus multilocularis regulator of G protein signaling 3 0.0018 0.0049 0.0072
Echinococcus granulosus regulator of G protein signaling 3 0.0018 0.0049 0.0072
Echinococcus granulosus G protein coupled receptor 139 0.0039 0.0287 0.0423
Brugia malayi hypothetical protein 0.0039 0.0287 0.071
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0027 0.0148 0.0339
Loa Loa (eye worm) hypothetical protein 0.0039 0.0278 0.0687
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0039 0.0287 0.0287
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0049 0.0394 0.0974
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0056 0.0462 0.0462
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0269 0.2797 0.6002
Loa Loa (eye worm) hypothetical protein 0.0018 0.0049 0.012
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0039 0.0287 0.0423
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0039 0.0287 0.0287
Schistosoma mansoni thyroid hormone receptor 0.0025 0.0129 0.0129
Loa Loa (eye worm) hypothetical protein 0.0039 0.0287 0.071
Brugia malayi Pyruvate kinase, muscle isozyme 0.0061 0.0527 0.1302
Echinococcus granulosus neuropeptides capa receptor 0.0039 0.0287 0.0423
Schistosoma mansoni aldehyde dehydrogenase 0.0056 0.0467 0.0467
Trichomonas vaginalis phosphofructokinase, putative 0.0052 0.0424 0.0824
Echinococcus multilocularis pyruvate kinase 0.0048 0.0386 0.0567
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0025 0.0129 0.0129
Entamoeba histolytica acyl-coA synthetase, putative 0.0039 0.0278 0.0835
Echinococcus granulosus FTZ F1 alpha 0.0025 0.0129 0.0189
Onchocerca volvulus 0.0024 0.0121 0.0162
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0027 0.0148 0.0365
Plasmodium vivax pyruvate kinase, putative 0.0061 0.0527 0.1611
Mycobacterium tuberculosis Probable esterase LipL 0.0017 0.0047 0.0007
Trypanosoma brucei NADH dehydrogenase 0.0027 0.0148 0.0339
Wolbachia endosymbiont of Brugia malayi NADPH-dependent glutamate synthase beta chain 0.0027 0.0148 0.0654
Plasmodium falciparum ferrodoxin reductase-like protein 0.0027 0.0148 0.0193
Echinococcus multilocularis beta LACTamase domain containing family member 0.0017 0.0047 0.0069
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0017 0.0047 0.0007
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0039 0.0287 0.0287
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0027 0.0148 0.0339
Loa Loa (eye worm) melatonin receptor type 1A 0.0039 0.0287 0.071
Schistosoma mansoni hypothetical protein 0.0039 0.0287 0.0287
Plasmodium vivax NAD(P)H-dependent glutamate synthase, putative 0.0027 0.0148 0.0339
Loa Loa (eye worm) hypothetical protein 0.0039 0.0287 0.071
Schistosoma mansoni bcl-2 homologous antagonist/killer (bak) 0.0055 0.0453 0.0453
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0039 0.0287 0.0423
Schistosoma mansoni neuropeptide receptor 0.0039 0.0287 0.0287
Trypanosoma cruzi NADH dehydrogenase, putative 0.0027 0.0148 0.0339
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0018 0.0049 0.012
Echinococcus multilocularis ecdysone induced protein 78C 0.0025 0.0129 0.0189
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0039 0.0287 0.0423
Onchocerca volvulus 0.0039 0.0287 0.0525
Onchocerca volvulus Bile acid receptor homolog 0.0025 0.0129 0.0179
Entamoeba histolytica pyruvate kinase, putative 0.0043 0.0324 0.1002
Entamoeba histolytica dihydropyrimidine dehydrogenase, putative 0.0027 0.0148 0.036
Schistosoma mansoni retinoic acid receptor RXR 0.0025 0.0129 0.0129
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0039 0.0287 0.0423
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0101 0.0956 0.1913
Schistosoma mansoni axis inhibition protein axin 0.0018 0.0049 0.0049
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0269 0.2797 0.6002
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0025 0.0129 0.0189
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0039 0.0287 0.0287
Echinococcus granulosus neuropeptides capa receptor 0.0039 0.0287 0.0423
Mycobacterium ulcerans ferredoxin reductase 0.0027 0.0148 0.0223
Brugia malayi Pre-SET motif family protein 0.0056 0.0462 0.1142
Echinococcus multilocularis pyruvate kinase 0.0032 0.02 0.0295
Echinococcus multilocularis apoptosis inducing factor 1 mitochondrial 0.0027 0.0148 0.0217
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0101 0.0956 1
Plasmodium falciparum NAD(P)H-dependent glutamate synthase, putative 0.0027 0.0148 0.0193
Loa Loa (eye worm) hypothetical protein 0.0039 0.0287 0.071
Echinococcus granulosus g protein coupled receptor 0.0039 0.0287 0.0423
Loa Loa (eye worm) hypothetical protein 0.0077 0.0693 0.171
Echinococcus granulosus neuropeptide Y receptor 0.0039 0.0287 0.0423
Plasmodium falciparum pyruvate kinase 2 0.0032 0.02 0.0372
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0039 0.0287 0.0423
Echinococcus granulosus tm gpcr rhodopsin 0.0039 0.0287 0.0423
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0056 0.0472 0.0902
Loa Loa (eye worm) hypothetical protein 0.0017 0.0047 0.0115
Loa Loa (eye worm) TAR-binding protein 0.0061 0.0527 0.1301
Loa Loa (eye worm) CXXC zinc finger family protein 0.0024 0.0121 0.0299
Loa Loa (eye worm) hypothetical protein 0.0039 0.0287 0.071
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0039 0.0287 0.0423
Mycobacterium ulcerans aldehyde dehydrogenase 0.0056 0.0467 0.0891
Loa Loa (eye worm) hypothetical protein 0.0039 0.0287 0.071
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0101 0.0956 0.3047
Plasmodium vivax multidomain scavenger receptor, putative 0.0036 0.0253 0.0691
Trypanosoma cruzi NADH dehydrogenase, putative 0.0027 0.0148 0.0339
Echinococcus granulosus peptide allatostatin:somatostatin 0.0039 0.0287 0.0423
Echinococcus granulosus rhodopsin orphan GPCR 0.0039 0.0287 0.0423
Echinococcus granulosus expressed protein 0.0344 0.3612 0.5312
Schistosoma mansoni amine GPCR 0.0039 0.0287 0.0287
Echinococcus multilocularis GPCR, family 2 0.0029 0.017 0.0249
Echinococcus multilocularis FTZ F1 alpha 0.0025 0.0129 0.0189
Schistosoma mansoni myosin xvIII 0.0039 0.0287 0.0287
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0027 0.0148 0.0217
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0025 0.0129 0.0189
Brugia malayi hypothetical protein 0.0039 0.0287 0.071
Schistosoma mansoni cpg binding protein 0.0026 0.0136 0.0136
Onchocerca volvulus 0.0039 0.0287 0.0525
Brugia malayi hypothetical protein 0.0039 0.0287 0.071
Toxoplasma gondii NADH dehydrogenase (NDH2-II) 0.0027 0.0148 0.0339
Trypanosoma brucei 2,4-dienoyl-coa reductase-like protein 0.0027 0.0148 0.0339
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0025 0.0129 0.0318
Loa Loa (eye worm) hypothetical protein 0.0061 0.0527 0.1302
Trypanosoma brucei pyruvate kinase 1, putative 0.0061 0.0527 0.1611
Loa Loa (eye worm) hypothetical protein 0.0039 0.0287 0.071
Mycobacterium ulcerans esterase/lipase LipP 0.0017 0.0047 0.0012
Schistosoma mansoni adenoreceptor 0.0039 0.0287 0.0287
Echinococcus multilocularis g-protein coupled receptor 0.0039 0.0287 0.0423
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0018 0.0049 0.012
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0527 0.0527
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0025 0.0129 0.0189
Echinococcus multilocularis pyruvate kinase 0.0061 0.0527 0.0775
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0022 0.0091 0.0149
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0027 0.0154 0.0144
Mycobacterium tuberculosis Probable NADPH:adrenodoxin oxidoreductase FprB (adrenodoxin reductase) (AR) (ferredoxin-NADP(+) reductase) 0.0027 0.0148 0.0136
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0029 0.0171 0.1427
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0039 0.0287 0.0287
Toxoplasma gondii phosphofructokinase PFKII 0.0052 0.0424 0.1266
Toxoplasma gondii pyruvate kinase PyK1 0.0061 0.0527 0.1611
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0017 0.0047 0.0007
Schistosoma mansoni neuropeptide receptor 0.0039 0.0287 0.0287
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0049 0.0005
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0027 0.0154 0.0144
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0027 0.0148 0.0339
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0101 0.0956 0.3047
Loa Loa (eye worm) hypothetical protein 0.0025 0.0129 0.0318
Loa Loa (eye worm) hypothetical protein 0.0027 0.0148 0.0365
Brugia malayi phosphofructokinase 0.0192 0.196 0.4838
Echinococcus multilocularis rhodopsin orphan GPCR 0.0039 0.0287 0.0423
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0101 0.0956 0.2942
Leishmania major ATP-dependent phosphofructokinase 0.0192 0.196 0.6414
Echinococcus multilocularis rhodopsin orphan GPCR 0.0039 0.0287 0.0423
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0056 0.0462 0.068
Plasmodium vivax ferrodoxin reductase, putative 0.0027 0.0148 0.0339
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0025 0.0129 0.0318
Schistosoma mansoni lipoxygenase 0.0094 0.0884 0.0884
Echinococcus multilocularis regulator of G protein signaling 7 0.0018 0.0049 0.0072
Brugia malayi MH2 domain containing protein 0.0014 0.0013 0.0033
Mycobacterium ulcerans acyl-CoA synthetase 0.0039 0.0278 0.0496
Echinococcus multilocularis neuropeptide FF receptor 2 0.0039 0.0287 0.0423
Loa Loa (eye worm) hypothetical protein 0.0039 0.0287 0.071
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0101 0.0956 0.3047
Echinococcus multilocularis axis inhibition protein axin 0.0018 0.0049 0.0072
Plasmodium falciparum LCCL domain-containing protein 0.0036 0.0253 0.055
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0027 0.0148 0.0221
Loa Loa (eye worm) transcription factor SMAD2 0.0211 0.2166 0.5349
Brugia malayi hypothetical protein 0.0039 0.0287 0.071
Mycobacterium tuberculosis Probable NADPH dependent 2,4-dienoyl-CoA reductase FadH (2,4-dienoyl coenzyme A reductase) (4-enoyl-CoA reductase) 0.0027 0.0148 0.0136
Loa Loa (eye worm) pyruvate kinase 0.0061 0.0527 0.1302
Echinococcus multilocularis neuropeptide receptor 0.0039 0.0287 0.0423
Onchocerca volvulus 0.0036 0.0253 0.045
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0039 0.0278 0.0302
Echinococcus multilocularis orexin receptor type 2 0.0039 0.0287 0.0423
Leishmania major NADH dehydrogenase, putative 0.0027 0.0148 0.0339
Echinococcus multilocularis allatostatin A receptor 0.0039 0.0287 0.0423
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0022 0.0091 0.0105
Echinococcus granulosus neuropeptide Y receptor 0.0039 0.0287 0.0423
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0269 0.2797 1
Loa Loa (eye worm) hypothetical protein 0.0025 0.0129 0.0318
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0025 0.0129 0.0189
Loa Loa (eye worm) hypothetical protein 0.0039 0.0287 0.071
Schistosoma mansoni biogenic amine receptor 0.0039 0.0287 0.0287
Schistosoma mansoni serine/threonine protein kinase 0.0018 0.0049 0.0049
Echinococcus granulosus Regulator of G protein signaling 20 0.0018 0.0049 0.0072
Loa Loa (eye worm) hypothetical protein 0.0018 0.0049 0.012
Schistosoma mansoni serine/threonine protein kinase 0.0018 0.0049 0.0049
Echinococcus granulosus mothers against decapentaplegic 5 0.0014 0.0013 0.002
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0101 0.0956 0.1405
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0025 0.0129 0.0318
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0027 0.0148 0.0221
Echinococcus multilocularis pyruvate kinase 0.0061 0.0527 0.0775
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.029 0.3029 0.3801
Chlamydia trachomatis pyruvate kinase 0.0061 0.0527 0.5317
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0662 0.7095 0.8972
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0039 0.0287 0.071
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0052 0.0424 0.0824
Schistosoma mansoni Smad4 0.0014 0.0013 0.0013
Brugia malayi Nuclear hormone receptor-like 1 0.0025 0.0129 0.0318
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0101 0.0956 0.3047
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0101 0.0956 0.3047
Brugia malayi G protein-coupled receptor F59B2.13 0.0039 0.0287 0.071
Schistosoma mansoni growth hormone secretagogue receptor 0.0039 0.0287 0.0287
Brugia malayi MH2 domain containing protein 0.0014 0.0013 0.0033
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0077 0.0693 0.171
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0192 0.196 0.6414
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0074 0.0664 0.1638
Brugia malayi Melatonin receptor type 1A 0.0039 0.0287 0.071
Plasmodium vivax pyruvate kinase 2, putative 0.0032 0.02 0.0516
Brugia malayi neuropeptide F receptor 0.0039 0.0287 0.071
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0025 0.0129 0.0318
Mycobacterium tuberculosis Conserved protein 0.0017 0.0047 0.0007
Mycobacterium ulcerans NADPH dependent 2,4-dienoyl-CoA reductase FadH 0.0027 0.0148 0.0223
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0027 0.0148 0.0217
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0025 0.0129 0.0318
Echinococcus granulosus beta-adrenergic receptor kinase 0.0018 0.0049 0.0072
Loa Loa (eye worm) doublecortin family protein 0.0036 0.0253 0.0624
Schistosoma mansoni amine GPCR 0.0039 0.0287 0.0287
Mycobacterium leprae Probable NADPH:adrenodoxin oxidoreductase FprA (NADPH-FERREDOXIN REDUCTASE) 0.0027 0.0148 0.0129
Schistosoma mansoni hypothetical protein 0.0029 0.017 0.017
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0018 0.0049 0.0049
Plasmodium falciparum glutathione reductase 0.0101 0.0956 0.2942
Brugia malayi putative neuropeptide receptor 0.0039 0.0287 0.071
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0039 0.0287 0.0287
Echinococcus multilocularis beta adrenergic receptor kinase 0.0018 0.0049 0.0072
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0039 0.0287 0.0423
Brugia malayi hypothetical protein 0.0039 0.0287 0.071
Mycobacterium ulcerans hypothetical protein 0.0017 0.0047 0.0012
Trypanosoma cruzi hypothetical protein, conserved 0.0027 0.0148 0.0339
Echinococcus granulosus fmrfamide receptor 0.0039 0.0287 0.0423
Echinococcus multilocularis G-protein coupled receptor, putative 0.0039 0.0287 0.0423
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0039 0.0287 0.071
Trichomonas vaginalis phosphofructokinase, putative 0.0192 0.196 0.4174
Loa Loa (eye worm) hypothetical protein 0.0025 0.0129 0.0318
Plasmodium falciparum glutathione reductase 0.029 0.3029 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0091 0.0847 0.2092
Loa Loa (eye worm) hypothetical protein 0.0091 0.0847 0.2092
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0025 0.0129 0.0318
Schistosoma mansoni glutamate synthase 0.0027 0.0148 0.0148
Echinococcus multilocularis pyruvate kinase 0.0032 0.02 0.0295
Schistosoma mansoni sulfide quinone reductase 0.0027 0.0148 0.0148
Loa Loa (eye worm) hypothetical protein 0.0029 0.0171 0.0423
Echinococcus multilocularis pyruvate kinase 0.0032 0.02 0.0295
Loa Loa (eye worm) hypothetical protein 0.0025 0.0129 0.0318
Brugia malayi PXA domain containing protein 0.0018 0.0049 0.012
Mycobacterium tuberculosis Probable thioredoxin reductase TrxB2 (TRXR) (TR) 0.0027 0.0148 0.0136
Mycobacterium leprae Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate 0.0027 0.0148 0.0129
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0018 0.0049 0.0049
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0101 0.0956 0.3047
Onchocerca volvulus Protein ultraspiracle homolog 0.0025 0.0129 0.0179
Entamoeba histolytica phosphofructokinase, putative 0.0192 0.196 0.6953
Schistosoma mansoni coup transcription factor 0.0025 0.0129 0.0129
Giardia lamblia Fructose-bisphosphate aldolase 0.0269 0.2797 1
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0052 0.0424 0.419
Loa Loa (eye worm) hypothetical protein 0.0039 0.0287 0.071
Onchocerca volvulus 0.0056 0.0462 0.0907
Onchocerca volvulus 0.0039 0.0278 0.0505
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0025 0.0129 0.0318
Echinococcus granulosus neuropeptide receptor 0.0039 0.0287 0.0423
Echinococcus granulosus pyruvate kinase 0.0061 0.0527 0.0775
Loa Loa (eye worm) 6-phosphofructokinase 0.0192 0.196 0.4838
Onchocerca volvulus Huntingtin homolog 0.0113 0.1089 0.2274
Mycobacterium ulcerans isopentenyl pyrophosphate isomerase 0.0163 0.1635 0.3336
Brugia malayi G protein-coupled receptor 0.0039 0.0287 0.071
Brugia malayi Dopamine receptor protein 1 0.0039 0.0287 0.071
Loa Loa (eye worm) hypothetical protein 0.0113 0.1089 0.2688
Echinococcus multilocularis 6 phosphofructokinase 0.0192 0.196 0.2882
Loa Loa (eye worm) hypothetical protein 0.0029 0.0171 0.0423
Leishmania major 4-coumarate:coa ligase-like protein 0.0039 0.0278 0.0776
Entamoeba histolytica phosphofructokinase, putative 0.0192 0.196 0.6953
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0042 0.0316 0.0316
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0056 0.0472 0.0472
Echinococcus multilocularis smad 0.0014 0.0013 0.002
Brugia malayi hypothetical protein 0.0113 0.1089 0.2688
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0017 0.0047 0.0007
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0052 0.0424 0.1133
Echinococcus granulosus neuropeptide receptor A26 0.0039 0.0287 0.0423
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0025 0.0129 0.0129
Echinococcus multilocularis Smad4 0.0014 0.0013 0.002
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0039 0.0287 0.0525
Brugia malayi Dopamine receptor 0.0039 0.0287 0.071
Echinococcus multilocularis neuropeptide Y receptor 0.0039 0.0287 0.0423
Schistosoma mansoni biogenic amine (5HT) receptor 0.0039 0.0287 0.0287
Echinococcus multilocularis rhodopsin orphan GPCR 0.0039 0.0287 0.0423
Brugia malayi hypothetical protein 0.0036 0.0253 0.0624
Echinococcus multilocularis Bcl 2 ous antagonist:killer 0.0055 0.0453 0.0667
Brugia malayi Regulator of G protein signaling domain containing protein 0.0018 0.0049 0.012
Brugia malayi hypothetical protein 0.0036 0.0253 0.0624
Schistosoma mansoni cpg binding protein 0.0024 0.0121 0.0121
Echinococcus multilocularis microtubule associated protein 2 0.0635 0.68 1
Echinococcus multilocularis expressed protein 0.0344 0.3612 0.5312
Trichomonas vaginalis pyruvate kinase, putative 0.0061 0.0527 0.1049
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0025 0.0129 0.0318
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0101 0.0956 0.3047
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0101 0.0956 0.3047
Trichomonas vaginalis phosphofructokinase, putative 0.0192 0.196 0.4174
Brugia malayi nuclear receptor NHR-88 0.0025 0.0129 0.0318
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0025 0.0129 0.0318
Loa Loa (eye worm) hypothetical protein 0.0039 0.0287 0.071
Brugia malayi Thioredoxin reductase 0.029 0.3029 0.7479
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0056 0.0462 0.0462
Mycobacterium tuberculosis Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate 0.0027 0.0148 0.0136
Brugia malayi hypothetical protein 0.0018 0.0049 0.012
Echinococcus multilocularis neuropeptide s receptor 0.0039 0.0287 0.0423
Plasmodium vivax SET domain protein, putative 0.0056 0.0462 0.1394
Loa Loa (eye worm) programmed cell death 8 0.0027 0.0148 0.0365
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0039 0.0287 0.0423
Schistosoma mansoni thyroid hormone receptor 0.0025 0.0129 0.0129
Brugia malayi Latrophilin receptor protein 2 0.0029 0.017 0.0419
Loa Loa (eye worm) hypothetical protein 0.0039 0.0287 0.071
Trichomonas vaginalis set domain proteins, putative 0.0437 0.4629 1
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0131 0.1293 0.1592
Onchocerca volvulus 0.0039 0.0287 0.0525
Trichomonas vaginalis phosphofructokinase, putative 0.0052 0.0424 0.0824
Echinococcus multilocularis dro:myosuppressin receptor 0.0039 0.0287 0.0423
Echinococcus multilocularis L aminoadipate semialdehyde 0.0077 0.0693 0.1018
Treponema pallidum NADH oxidase 0.0101 0.0956 0.1913
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0039 0.0287 0.0287
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0269 0.2797 0.6002
Brugia malayi sulfakinin receptor protein 0.0039 0.0287 0.071
Echinococcus granulosus glutamate synthase 0.0027 0.0148 0.0217
Toxoplasma gondii NADPH-glutathione reductase 0.0101 0.0956 0.3047
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0101 0.0956 0.1913
Loa Loa (eye worm) hypothetical protein 0.0029 0.017 0.0419
Schistosoma mansoni neuropeptide receptor 0.0039 0.0287 0.0287
Loa Loa (eye worm) hypothetical protein 0.0039 0.0287 0.071
Onchocerca volvulus 0.0039 0.0287 0.0525
Trypanosoma brucei isopentenyl-diphosphate delta-isomerase (type II) 0.0163 0.1635 0.5326
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0022 0.0091 0.0105
Plasmodium vivax 6-phosphofructokinase, putative 0.0052 0.0424 0.1266
Loa Loa (eye worm) hypothetical protein 0.0046 0.0354 0.0873
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0022 0.0091 0.0064
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0027 0.0148 0.0365
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0027 0.0148 0.0221
Giardia lamblia Pyruvate kinase 0.0032 0.02 0.0199
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0159 0.1598 0.235
Echinococcus multilocularis thioredoxin glutathione reductase 0.0293 0.3053 0.449
Loa Loa (eye worm) hypothetical protein 0.0039 0.0287 0.071
Echinococcus multilocularis cpg binding protein 0.0026 0.0136 0.02
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0056 0.0467 0.0542
Trichomonas vaginalis phosphofructokinase, putative 0.0192 0.196 0.4174
Loa Loa (eye worm) MH2 domain-containing protein 0.0014 0.0013 0.0033
Trichomonas vaginalis glutamate synthase, putative 0.0027 0.0148 0.0221
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0025 0.0129 0.0318
Loa Loa (eye worm) hypothetical protein 0.0017 0.0047 0.0115
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0052 0.0424 0.1366
Plasmodium falciparum pyruvate kinase 0.0061 0.0527 0.1484
Schistosoma mansoni smad1 5 8 and 0.0014 0.0013 0.0013
Mycobacterium ulcerans aldehyde dehydrogenase 0.0056 0.0467 0.0891
Echinococcus granulosus neuropeptide FF receptor 2 0.0039 0.0287 0.0423
Brugia malayi hypothetical protein 0.0039 0.0287 0.071
Loa Loa (eye worm) hypothetical protein 0.0039 0.0287 0.071
Loa Loa (eye worm) hypothetical protein 0.0017 0.0047 0.0115
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0056 0.0472 0.0694
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0018 0.0049 0.012
Brugia malayi beta-lactamase 0.0017 0.0047 0.0115
Loa Loa (eye worm) hypothetical protein 0.0039 0.0287 0.071
Schistosoma mansoni aldehyde dehydrogenase 0.0056 0.0467 0.0467
Schistosoma mansoni glutamate synthase 0.0027 0.0148 0.0148
Echinococcus multilocularis regulator of G protein signaling 7 0.0018 0.0049 0.0072
Loa Loa (eye worm) G-protein coupled receptor 0.0039 0.0287 0.071
Brugia malayi Serotonin receptor 0.0039 0.0287 0.071
Treponema pallidum oxidoreductase 0.0027 0.0148 0.0223
Brugia malayi GnHR receptor homolog 0.0039 0.0287 0.071
Trypanosoma cruzi 2,4-dienoyl-coa reductase-like protein, putative 0.0027 0.0148 0.0339
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0039 0.0287 0.0287
Toxoplasma gondii histone lysine methyltransferase SET1 0.0048 0.038 0.1118
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0192 0.196 0.2435
Echinococcus multilocularis thyroid hormone receptor alpha 0.0025 0.0129 0.0189
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0039 0.0287 0.0423
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0039 0.0287 0.071
Brugia malayi MH1 domain containing protein 0.0014 0.0013 0.0033
Toxoplasma gondii 6-phosphofructokinase 0.0052 0.0424 0.1266
Schistosoma mansoni hypothetical protein 0.0156 0.1561 0.1561
Brugia malayi glutamate synthase 0.0027 0.0148 0.0365
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0056 0.0467 0.0687
Mycobacterium tuberculosis Conserved protein 0.0017 0.0047 0.0007
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0077 0.0693 0.0693
Echinococcus multilocularis somatostatin receptor 0.0039 0.0287 0.0423
Schistosoma mansoni biogenic amine receptor 0.0039 0.0287 0.0287
Echinococcus granulosus nmda type glutamate receptor 0.0024 0.0113 0.0166
Trichomonas vaginalis glutathione reductase, putative 0.0101 0.0956 0.1983
Loa Loa (eye worm) MH2 domain-containing protein 0.0211 0.2166 0.5349
Echinococcus granulosus rhodopsin orphan GPCR 0.0039 0.0287 0.0423
Mycobacterium ulcerans glutamate synthase subunit beta 0.0027 0.0148 0.0223
Mycobacterium ulcerans L-lactate dehydrogenase (cytochrome) LldD1 0.0163 0.1635 0.3336
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0039 0.0278 0.0496
Echinococcus granulosus rhodopsin orphan GPCR 0.0039 0.0287 0.0423
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0056 0.0472 0.0902
Echinococcus granulosus tar DNA binding protein 0.0061 0.0527 0.0775
Echinococcus granulosus pyruvate kinase 0.0032 0.02 0.0295
Brugia malayi hypothetical protein 0.0039 0.0287 0.071
Onchocerca volvulus 0.0018 0.0058 0.0024
Loa Loa (eye worm) hypothetical protein 0.0039 0.0287 0.071
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0052 0.0424 0.419
Brugia malayi beta-lactamase family protein 0.0017 0.0047 0.0115
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.0027 0.0148 0.0223
Echinococcus granulosus tm gpcr rhodopsin 0.0039 0.0287 0.0423
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0017 0.0047 0.0115
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0039 0.0287 0.0287
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0025 0.0129 0.0189
Mycobacterium leprae POSSIBLE L-LACTATE DEHYDROGENASE (CYTOCHROME) LLDD2 0.0454 0.4821 0.6077
Echinococcus multilocularis neuropeptide receptor A26 0.0039 0.0287 0.0423
Schistosoma mansoni amine GPCR 0.0039 0.0287 0.0287
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0039 0.0287 0.071
Onchocerca volvulus 0.0039 0.0287 0.0525
Trichomonas vaginalis phosphofructokinase, putative 0.0192 0.196 0.4174
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0039 0.0278 0.0295
Trypanosoma cruzi pyruvate kinase 2, putative 0.0061 0.0527 0.1611
Schistosoma mansoni sulfide quinone reductase 0.0027 0.0148 0.0148
Loa Loa (eye worm) hypothetical protein 0.0039 0.0287 0.071
Echinococcus multilocularis rhodopsin orphan GPCR 0.0039 0.0287 0.0423
Loa Loa (eye worm) 6-phosphofructokinase 0.0192 0.196 0.4838
Echinococcus granulosus hypothetical protein 0.0039 0.0287 0.0423
Loa Loa (eye worm) hypothetical protein 0.0043 0.0324 0.08
Onchocerca volvulus 0.0039 0.0287 0.0525
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0384 0.405 1
Brugia malayi Apoptosis regulator proteins, Bcl-2 family protein 0.0055 0.0453 0.1119
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0056 0.0462 0.0462
Treponema pallidum hypothetical protein 0.0454 0.4821 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0269 0.2797 0.6002
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0042 0.0316 0.0465
Loa Loa (eye worm) hypothetical protein 0.0039 0.0287 0.071
Echinococcus multilocularis geminin 0.0156 0.1561 0.2296
Schistosoma mansoni steroid hormone receptor ad4bp 0.0025 0.0129 0.0129
Trichomonas vaginalis glutamate synthase, putative 0.0027 0.0148 0.0221
Loa Loa (eye worm) hypothetical protein 0.0139 0.1377 0.3398
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0269 0.2797 0.6002
Echinococcus granulosus L aminoadipate semialdehyde 0.0077 0.0693 0.1018
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0022 0.0091 0.0549
Mycobacterium leprae PROBABLE NADPH:ADRENODOXIN OXIDOREDUCTASE FPRB (ADRENODOXIN REDUCTASE) (AR) (FERREDOXIN-NADP(+) REDUCTASE) 0.0027 0.0148 0.0129
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0039 0.0287 0.0423
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0025 0.0129 0.0318
Loa Loa (eye worm) hypothetical protein 0.0039 0.0287 0.071
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0052 0.0424 0.1133
Echinococcus granulosus tumor protein p63 0.0311 0.3256 0.4788
Trypanosoma brucei RNA helicase, putative 0.0171 0.173 0.5644
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0014 0.0013 0.002
Echinococcus granulosus axis inhibition protein axin 0.0018 0.0049 0.0072
Echinococcus multilocularis EGFP:Bcl2 fusion protein 0.0055 0.0453 0.0667
Wolbachia endosymbiont of Brugia malayi thioredoxin reductase 0.0027 0.0148 0.0654
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0039 0.0278 0.0302
Brugia malayi Doublecortin family protein 0.0036 0.0253 0.0624
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0014 0.0013 0.0013
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0061 0.0527 0.0619
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0074 0.0664 0.1638
Brugia malayi RNA recognition motif domain containing protein 0.0061 0.0527 0.1301
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0039 0.0287 0.0423
Echinococcus granulosus allatostatin A receptor 0.0039 0.0287 0.0423
Echinococcus granulosus somatostatin receptor 0.0039 0.0287 0.0423
Mycobacterium ulcerans dehydrogenase 0.0027 0.0148 0.0223
Echinococcus granulosus pyruvate kinase 0.0032 0.02 0.0295
Leishmania major pyruvate kinase 0.0061 0.0527 0.1611
Brugia malayi AMP-binding enzyme family protein 0.0039 0.0278 0.0687
Echinococcus multilocularis tar DNA binding protein 0.0061 0.0527 0.0775
Trichomonas vaginalis phosphofructokinase, putative 0.0052 0.0424 0.0824
Treponema pallidum fructose-bisphosphate aldolase 0.0269 0.2797 0.5766
Echinococcus granulosus apoptosis inducing factor 1 mitochondrial 0.0027 0.0148 0.0217
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0056 0.0472 0.0548
Loa Loa (eye worm) hypothetical protein 0.0039 0.0287 0.071
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0056 0.0462 0.068
Schistosoma mansoni polycystin 1-related 0.0036 0.0253 0.0253
Loa Loa (eye worm) hypothetical protein 0.0039 0.0278 0.0687
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0017 0.0047 0.0115
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0025 0.0129 0.0318
Trypanosoma brucei trypanothione reductase 0.029 0.3029 1
Schistosoma mansoni regulator of G protein signaling 0.0018 0.0049 0.0049
Trypanosoma cruzi trypanothione reductase, putative 0.029 0.3029 1
Schistosoma mansoni hypothetical protein 0.0039 0.0287 0.0287
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0101 0.0956 0.3047
Schistosoma mansoni hypothetical protein 0.0039 0.0287 0.0287
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0042 0.0316 0.0781
Loa Loa (eye worm) hypothetical protein 0.0039 0.0287 0.071
Brugia malayi CXXC zinc finger family protein 0.0024 0.0121 0.0299
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.0027 0.0148 0.0221
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0049 0.0005
Loa Loa (eye worm) TYRA-2 protein 0.0039 0.0287 0.071
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0017 0.0047 0.0047
Echinococcus granulosus 7tm_1 domain containing protein 0.0039 0.0287 0.0423
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0025 0.0129 0.0189
Schistosoma mansoni 6-phosphofructokinase 0.0192 0.196 0.196
Brugia malayi hypothetical protein 0.0039 0.0287 0.071
Loa Loa (eye worm) hypothetical protein 0.0018 0.0049 0.012
Echinococcus granulosus histone lysine methyltransferase setb 0.0056 0.0462 0.068
Mycobacterium ulcerans NADH dehydrogenase 0.0027 0.0148 0.0223
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0101 0.0956 1
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0039 0.0287 0.0423
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0039 0.0287 0.0423
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0101 0.0956 0.3047
Mycobacterium tuberculosis Possible L-lactate dehydrogenase (cytochrome) LldD2 0.0454 0.4821 0.608
Entamoeba histolytica pyridine nucleotide-disulfide oxidoreductase family protein 0.0027 0.0148 0.036
Loa Loa (eye worm) hypothetical protein 0.0039 0.0287 0.071
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0061 0.0527 0.1301
Echinococcus multilocularis mothers against decapentaplegic 5 0.0014 0.0013 0.002
Brugia malayi A-kinase anchor protein 10, precursor 0.0018 0.0049 0.012
Plasmodium vivax acyl-CoA synthetase, putative 0.0029 0.0171 0.0418
Loa Loa (eye worm) hypothetical protein 0.0039 0.0287 0.071
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0039 0.0287 0.0423
Echinococcus multilocularis g protein coupled receptor 0.0039 0.0287 0.0423
Echinococcus granulosus sex peptide receptor 0.0039 0.0287 0.0423
Mycobacterium tuberculosis Probable lipase LipD 0.0017 0.0047 0.0007
Schistosoma mansoni neuropeptide f receptor 76f 0.0039 0.0287 0.0287
Onchocerca volvulus 0.0437 0.4629 1
Echinococcus multilocularis pyridine nucleotide disulfide oxidoreductase 0.0027 0.0148 0.0217
Loa Loa (eye worm) RNA binding protein 0.0061 0.0527 0.1301
Schistosoma mansoni opsin-like receptor 0.0039 0.0287 0.0287
Leishmania major trypanothione reductase 0.029 0.3029 1
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0056 0.0472 0.1426
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0018 0.0049 0.0072
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0029 0.017 0.0249
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0042 0.0316 0.0316
Trypanosoma brucei hypothetical protein, conserved 0.0027 0.0148 0.0339
Loa Loa (eye worm) hypothetical protein 0.0018 0.0049 0.012
Onchocerca volvulus 0.0036 0.0253 0.045
Mycobacterium tuberculosis Probable oxidoreductase 0.0736 0.7902 1
Plasmodium falciparum acyl-CoA synthetase 0.0029 0.0171 0.0273
Loa Loa (eye worm) steroid hormone receptor 0.0025 0.0129 0.0318
Schistosoma mansoni regulator of G protein signaling 0.0018 0.0049 0.0049
Leishmania major 4-coumarate:coa ligase-like protein 0.0039 0.0278 0.0776
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0101 0.0956 0.1913
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0192 0.196 0.6414
Mycobacterium ulcerans 6-phosphofructokinase 0.0192 0.196 0.4014
Onchocerca volvulus 0.0027 0.0148 0.0221
Loa Loa (eye worm) hypothetical protein 0.0017 0.0047 0.0115
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0056 0.0472 0.1165
Onchocerca volvulus 0.0039 0.0287 0.0525
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0056 0.0472 0.0694
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0039 0.0287 0.0287
Loa Loa (eye worm) hypothetical protein 0.0039 0.0287 0.071
Loa Loa (eye worm) hypothetical protein 0.0039 0.0287 0.071
Mycobacterium ulcerans hypothetical protein 0.0027 0.0148 0.0223
Echinococcus granulosus pyruvate kinase 0.0032 0.02 0.0295
Echinococcus multilocularis fmrfamide receptor 0.0039 0.0287 0.0423
Loa Loa (eye worm) hypothetical protein 0.0039 0.0287 0.071
Echinococcus multilocularis RUN 0.0036 0.0253 0.0372
Brugia malayi NADPH:adrenodoxin oxidoreductase, mitochondrial precursor 0.0027 0.0148 0.0365
Entamoeba histolytica hypothetical protein 0.0022 0.0091 0.0154
Plasmodium vivax thioredoxin reductase, putative 0.029 0.3029 1
Schistosoma mansoni pyruvate kinase 0.0061 0.0527 0.0527
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0091 0.0847 0.2092
Entamoeba histolytica isopentenyl-diphosphate delta-isomerase, putative 0.0163 0.1635 0.5773
Toxoplasma gondii aldehyde dehydrogenase 0.0056 0.0467 0.1409
Echinococcus granulosus regulator of G protein signaling 7 0.0018 0.0049 0.0072
Echinococcus granulosus pyridine nucleotide disulfide oxidoreductase 0.0027 0.0148 0.0217
Brugia malayi 6-phosphofructokinase 0.0192 0.196 0.4838
Echinococcus multilocularis G protein coupled receptor 139 0.0039 0.0287 0.0423
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0053 0.044 0.044
Schistosoma mansoni smad1 5 8 and 0.0014 0.0013 0.0013
Brugia malayi beta-lactamase family protein 0.0017 0.0047 0.0115
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0039 0.0278 0.0295
Wolbachia endosymbiont of Brugia malayi thioredoxin reductase 0.0027 0.0148 0.0654
Schistosoma mansoni loxhd1 0.0036 0.0253 0.0253
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0269 0.2797 0.6002
Echinococcus multilocularis rhodopsin orphan GPCR 0.0039 0.0287 0.0423
Echinococcus multilocularis nmda type glutamate receptor 0.0024 0.0113 0.0166
Onchocerca volvulus Neuropeptide F receptor homolog 0.0039 0.0287 0.0525
Loa Loa (eye worm) hypothetical protein 0.0039 0.0287 0.071
Loa Loa (eye worm) hypothetical protein 0.0025 0.0129 0.0318
Schistosoma mansoni opsin-like receptor 0.0039 0.0287 0.0287
Echinococcus multilocularis sulfide:quinone oxidoreductase 0.0027 0.0148 0.0217
Echinococcus granulosus g protein coupled receptor 0.0039 0.0287 0.0423
Loa Loa (eye worm) hypothetical protein 0.0039 0.0287 0.071
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0101 0.0956 0.1163
Brugia malayi photoreceptor-specific nuclear receptor 0.0025 0.0129 0.0318
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0039 0.0287 0.071
Onchocerca volvulus 0.0039 0.0287 0.0525
Loa Loa (eye worm) Smad1 0.0014 0.0013 0.0033
Schistosoma mansoni biogenic amine (5HT) receptor 0.0039 0.0287 0.0287
Echinococcus granulosus rhodopsin orphan GPCR 0.0039 0.0287 0.0423
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0029 0.0171 0.0273
Echinococcus granulosus sulfide:quinone oxidoreductase 0.0027 0.0148 0.0217
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0027 0.0148 0.0339
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0027 0.0148 0.0221
Echinococcus granulosus g-protein coupled receptor 0.0039 0.0287 0.0423
Loa Loa (eye worm) hypothetical protein 0.0036 0.0253 0.0624
Echinococcus granulosus ecdysone induced protein 78C 0.0025 0.0129 0.0189
Trypanosoma cruzi 2,4-dienoyl-coa reductase fadh1, putative 0.0027 0.0148 0.0339
Schistosoma mansoni biogenic amine receptor 0.0039 0.0287 0.0287
Echinococcus multilocularis serotonin receptor 0.0039 0.0287 0.0423
Mycobacterium tuberculosis NADPH:adrenodoxin oxidoreductase FprA (NADPH-ferredoxin reductase) 0.0027 0.0148 0.0136
Mycobacterium ulcerans NADH dehydrogenase Ndh1 0.0027 0.0148 0.0223
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0039 0.0287 0.0287
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0025 0.0129 0.0318
Mycobacterium leprae Probable pyruvate kinase PykA 0.0061 0.0527 0.0612
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0027 0.0154 0.0144
Echinococcus multilocularis axis inhibition protein axin 0.0018 0.0049 0.0072
Echinococcus granulosus cpg binding protein 0.0026 0.0136 0.02
Loa Loa (eye worm) hypothetical protein 0.0055 0.0453 0.1119
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0039 0.0287 0.0287
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0039 0.0287 0.0287
Mycobacterium tuberculosis Probable hydrolase 0.0017 0.0047 0.0007
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0052 0.0424 0.0802
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0025 0.0129 0.0189
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0027 0.0154 0.0144
Schistosoma mansoni pyruvate kinase 0.0032 0.02 0.02
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0025 0.0129 0.0179
Brugia malayi larval opioid receptor 0.0039 0.0287 0.071
Leishmania major hypothetical protein, conserved 0.0027 0.0148 0.0339
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0039 0.0278 0.0496
Brugia malayi ORL1-like opioid receptor 0.0039 0.0287 0.071
Loa Loa (eye worm) hypothetical protein 0.0039 0.0287 0.071
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0029 0.017 0.0249
Brugia malayi glutathione reductase 0.029 0.3029 0.7479
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0039 0.0287 0.0287
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0049 0.0005
Brugia malayi Pyruvate kinase, M2 isozyme 0.0061 0.0527 0.1302
Schistosoma mansoni regulator of G protein signaling 0.0018 0.0049 0.0049
Loa Loa (eye worm) pyruvate kinase-PB 0.0043 0.0324 0.08
Onchocerca volvulus 0.0039 0.0287 0.0525
Leishmania major 4-coumarate:coa ligase-like protein 0.0039 0.0278 0.0776
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0042 0.0316 0.0316
Onchocerca volvulus Pyruvate kinase homolog 0.0061 0.0527 0.1049
Trypanosoma brucei pyruvate kinase 1 0.0061 0.0527 0.1611
Loa Loa (eye worm) hypothetical protein 0.0062 0.0534 0.1317
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0101 0.0956 0.1405
Schistosoma mansoni neuropeptide receptor 0.0039 0.0287 0.0287
Brugia malayi Regulator of G protein signaling domain containing protein 0.0018 0.0049 0.012
Schistosoma mansoni opsin-like receptor 0.0039 0.0287 0.0287
Echinococcus multilocularis neuropeptides capa receptor 0.0039 0.0287 0.0423
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0049 0.0005
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0039 0.0287 0.0287
Brugia malayi MH2 domain containing protein 0.0211 0.2166 0.5349
Trypanosoma cruzi pyruvate kinase 2, putative 0.0061 0.0527 0.1611
Toxoplasma gondii pyruvate kinase PyKII 0.0032 0.02 0.0516
Brugia malayi G-protein coupled receptor 0.0039 0.0287 0.071
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0039 0.0287 0.071
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0039 0.0287 0.071
Loa Loa (eye worm) hypothetical protein 0.0039 0.0287 0.071
Mycobacterium tuberculosis Probable reductase 0.0662 0.7095 0.8972
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprB 0.0027 0.0148 0.0223
Onchocerca volvulus 0.0077 0.0693 0.1409
Loa Loa (eye worm) hypothetical protein 0.0039 0.0287 0.071
Plasmodium falciparum thioredoxin reductase 0.0101 0.0956 0.2942
Mycobacterium ulcerans L-lactate dehydrogenase (cytochrome) LldD2 0.0454 0.4821 1
Loa Loa (eye worm) hypothetical protein 0.0025 0.0129 0.0318
Schistosoma mansoni smad1 5 8 and 0.0014 0.0013 0.0013
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0269 0.2797 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0042 0.0316 0.0465
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0736 0.7902 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0025 0.0129 0.0318
Trichomonas vaginalis phosphofructokinase, putative 0.0052 0.0424 0.0824
Plasmodium vivax 6-phosphofructokinase, putative 0.0052 0.0424 0.1266
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0039 0.0287 0.0287
Loa Loa (eye worm) hypothetical protein 0.0039 0.0287 0.071
Trypanosoma cruzi NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0027 0.0148 0.0339
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0101 0.0956 0.3047
Echinococcus multilocularis regulator of G protein signaling 0.0018 0.0049 0.0072
Onchocerca volvulus Pyruvate kinase homolog 0.0061 0.0527 0.1049
Schistosoma mansoni hypothetical protein 0.0039 0.0287 0.0287
Schistosoma mansoni cpg binding protein 0.0026 0.0136 0.0136
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0025 0.0129 0.0129
Mycobacterium ulcerans aldehyde dehydrogenase 0.0056 0.0467 0.0891
Echinococcus granulosus neuropeptide s receptor 0.0039 0.0287 0.0423
Brugia malayi PXA domain containing protein 0.0018 0.0049 0.012
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0101 0.0956 0.3047
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0027 0.0148 0.036
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0039 0.0287 0.071
Loa Loa (eye worm) hypothetical protein 0.0017 0.0047 0.0115
Echinococcus multilocularis rhodopsin orphan GPCR 0.0039 0.0287 0.0423
Echinococcus granulosus regulator of G protein signaling 3 0.0018 0.0049 0.0072
Loa Loa (eye worm) hypothetical protein 0.0017 0.0047 0.0115
Loa Loa (eye worm) hypothetical protein 0.0056 0.0462 0.1142
Schistosoma mansoni hypothetical protein 0.0029 0.017 0.017
Loa Loa (eye worm) glutathione reductase 0.029 0.3029 0.7479
Mycobacterium ulcerans pyruvate kinase 0.0061 0.0527 0.1017
Schistosoma mansoni hypothetical protein 0.0055 0.0453 0.0453
Onchocerca volvulus 0.0039 0.0287 0.0525
Echinococcus granulosus serotonin receptor 0.0039 0.0287 0.0423
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0039 0.0287 0.071
Loa Loa (eye worm) hypothetical protein 0.0039 0.0287 0.071
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0025 0.0129 0.0189
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0042 0.0316 0.0465
Echinococcus granulosus Bcl 2 ous antagonist:killer 0.0055 0.0453 0.0667
Mycobacterium tuberculosis Probable dehydrogenase 0.0662 0.7095 0.8972
Echinococcus multilocularis glutamate synthase 0.0027 0.0148 0.0217
Loa Loa (eye worm) hypothetical protein 0.0039 0.0287 0.071
Brugia malayi Smad1 0.0014 0.0013 0.0033
Schistosoma mansoni hypothetical protein 0.0027 0.0148 0.0148
Plasmodium vivax type II NADH:ubiquinone oxidoreductase, putative 0.0027 0.0148 0.0339
Echinococcus granulosus smad 0.0014 0.0013 0.002
Echinococcus granulosus lipoxygenase domain containing protein 0.0036 0.0253 0.0372
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0056 0.0467 0.1409
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0269 0.2797 0.6002
Echinococcus granulosus 7TM GPCR rhodopsin 0.0039 0.0287 0.0423
Loa Loa (eye worm) pyridine nucleotide-disufhide oxidoreductase 0.0027 0.0148 0.0365
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0527 0.0527
Schistosoma mansoni amine GPCR 0.0039 0.0287 0.0287
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0042 0.0316 0.0781
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0025 0.0129 0.0189
Loa Loa (eye worm) hypothetical protein 0.0039 0.0287 0.071
Loa Loa (eye worm) MH1 domain-containing protein 0.0014 0.0013 0.0033
Brugia malayi ecdysteroid receptor 0.0025 0.0129 0.0318
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0101 0.0956 0.3047
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0049 0.0005
Entamoeba histolytica thioredoxin reductase, putative 0.0027 0.0148 0.036
Echinococcus granulosus Smad4 0.0014 0.0013 0.002
Loa Loa (eye worm) hypothetical protein 0.0039 0.0287 0.071
Leishmania major hypothetical protein, conserved 0.0027 0.0148 0.0339
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0025 0.0129 0.0129
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0056 0.0467 0.0687
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0039 0.0287 0.0287
Loa Loa (eye worm) PXA domain-containing protein 0.0018 0.0049 0.012
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0029 0.0171 0.0166
Schistosoma mansoni pyruvate kinase 0.0061 0.0527 0.0527
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0025 0.0129 0.0318
Trichomonas vaginalis phosphofructokinase, putative 0.0052 0.0424 0.0824
Brugia malayi regulator of G-protein signaling egl-10 0.0018 0.0049 0.012
Loa Loa (eye worm) neuropeptide F receptor 0.0039 0.0287 0.071
Mycobacterium ulcerans acyl-CoA synthetase 0.0039 0.0278 0.0496
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0027 0.0148 0.0339
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0027 0.0148 0.0339
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.0027 0.0148 0.0223
Echinococcus granulosus axis inhibition protein axin 0.0018 0.0049 0.0072
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0101 0.0956 0.3047
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0027 0.0148 0.0217
Schistosoma mansoni cellular tumor antigen P53 0.0046 0.0354 0.0354
Loa Loa (eye worm) hypothetical protein 0.0039 0.0278 0.0687
Trypanosoma cruzi hypothetical protein, conserved 0.0027 0.0148 0.0339
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0101 0.0956 0.0956
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0039 0.0287 0.0287
Toxoplasma gondii thioredoxin reductase 0.029 0.3029 1
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0736 0.7902 1
Schistosoma mansoni disulfide oxidoreductase 0.0027 0.0148 0.0148
Mycobacterium tuberculosis Probable lipase LipE 0.0017 0.0047 0.0007
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0025 0.0129 0.0318
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0662 0.7095 0.8972
Brugia malayi hypothetical protein 0.0139 0.1377 0.3398
Trichomonas vaginalis dihydrolipoamide dehydrogenase, putative 0.0027 0.0148 0.0221
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0029 0.017 0.0249
Echinococcus granulosus tm gpcr rhodopsin 0.0039 0.0287 0.0423
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0049 0.0005
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0101 0.0956 0.2942
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0039 0.0287 0.0287
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0052 0.0424 0.1043
Schistosoma mansoni hypothetical protein 0.0036 0.0253 0.0253
Loa Loa (eye worm) RGS-3 protein 0.0018 0.0049 0.012
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0025 0.0129 0.0189
Schistosoma mansoni hypothetical protein 0.0156 0.1561 0.1561
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0039 0.0287 0.0423
Trichomonas vaginalis mercuric reductase, putative 0.0101 0.0956 0.1983
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.0024 0.0113 0.0166
Mycobacterium leprae conserved hypothetical protein 0.0022 0.0091 0.0057
Onchocerca volvulus 0.0039 0.0287 0.0525
Loa Loa (eye worm) beta-lactamase 0.0017 0.0047 0.0115
Schistosoma mansoni amine GPCR 0.0039 0.0287 0.0287
Schistosoma mansoni alpha-1 adrenergic receptor 0.0039 0.0287 0.0287
Schistosoma mansoni neuropeptide F-like receptor 0.0039 0.0287 0.0287
Mycobacterium tuberculosis Possible dehydrogenase/reductase 0.0027 0.0148 0.0136
Mycobacterium ulcerans lipase LipD 0.0017 0.0047 0.0012
Onchocerca volvulus 0.0039 0.0287 0.0525
Schistosoma mansoni microtubule-associated protein tau 0.0635 0.68 0.68
Brugia malayi hypothetical protein 0.0039 0.0287 0.071
Loa Loa (eye worm) hypothetical protein 0.0025 0.0129 0.0318
Trypanosoma brucei NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0027 0.0148 0.0339
Brugia malayi putative neuropeptide receptor NPR1 0.0039 0.0287 0.071
Chlamydia trachomatis thioredoxin reductase 0.0027 0.0148 0.1168
Brugia malayi regulator of G-protein signaling rgs-7 0.0018 0.0049 0.012
Schistosoma mansoni nuclear hormone receptor 0.0025 0.0129 0.0129
Echinococcus multilocularis lipoxygenase domain containing protein 0.0036 0.0253 0.0372
Echinococcus multilocularis tumor protein p63 0.0311 0.3256 0.4788
Echinococcus granulosus NADPH:adrenodoxin oxidoreductase 0.0027 0.0148 0.0217
Brugia malayi Steroid receptor seven-up type 2 0.0025 0.0129 0.0318
Brugia malayi Calcitonin receptor-like protein seb-1 0.0091 0.0847 0.2092
Brugia malayi G-protein coupled receptor 0.0039 0.0287 0.071
Echinococcus multilocularis fmrfamide receptor 0.0039 0.0287 0.0423
Brugia malayi MH1 domain containing protein 0.0014 0.0013 0.0033
Toxoplasma gondii selenide, water dikinase 0.0027 0.0148 0.0339
Echinococcus multilocularis Regulator of G protein signaling 20 0.0018 0.0049 0.0072
Echinococcus granulosus beta LACTamase domain containing family member 0.0017 0.0047 0.0069
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0039 0.0287 0.0423
Echinococcus multilocularis NADPH:adrenodoxin oxidoreductase 0.0027 0.0148 0.0217
Echinococcus granulosus neuropeptide receptor 0.0039 0.0287 0.0423
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0039 0.0287 0.0287
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0027 0.0148 0.0221
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0022 0.0091 0.0149
Echinococcus granulosus rhodopsin orphan GPCR 0.0039 0.0287 0.0423
Leishmania major phosphopantetheinyl transferase-like protein 0.0022 0.0091 0.0149
Onchocerca volvulus 0.0039 0.0287 0.0525
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0192 0.196 0.244
Schistosoma mansoni neuropeptide F-like receptor 0.0039 0.0287 0.0287
Schistosoma mansoni rab6-interacting 0.0036 0.0253 0.0253
Echinococcus multilocularis serotonin receptor 0.0039 0.0287 0.0423
Loa Loa (eye worm) hypothetical protein 0.0036 0.0253 0.0624
Echinococcus granulosus thioredoxin glutathione reductase 0.0293 0.3053 0.449
Echinococcus multilocularis neuropeptide receptor 0.0039 0.0287 0.0423
Echinococcus granulosus alpha 1A adrenergic receptor 0.0039 0.0287 0.0423
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0029 0.017 0.0249
Loa Loa (eye worm) neuropeptide F receptor 0.0039 0.0287 0.071
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0027 0.0148 0.036
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0025 0.0129 0.0129
Loa Loa (eye worm) pyruvate kinase 0.0061 0.0527 0.1302
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0039 0.0287 0.0423
Schistosoma mansoni hypothetical protein 0.0171 0.173 0.173
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0159 0.1598 0.235
Schistosoma mansoni smad 0.0014 0.0013 0.0013
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0022 0.0091 0.0105
Leishmania major 2,4-dienoyl-coa reductase-like protein 0.0027 0.0148 0.0339
Loa Loa (eye worm) hypothetical protein 0.0039 0.0287 0.071
Loa Loa (eye worm) hypothetical protein 0.0029 0.0171 0.0423
Schistosoma mansoni RAR-like nuclear receptor 0.0025 0.0129 0.0129
Plasmodium vivax glutathione reductase, putative 0.029 0.3029 1
Brugia malayi RNA binding protein 0.0061 0.0527 0.1301
Echinococcus granulosus dro:myosuppressin receptor 0.0039 0.0287 0.0423
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0027 0.0148 0.0221
Onchocerca volvulus 0.0039 0.0287 0.0525
Echinococcus granulosus EGFP:Bcl2 fusion protein 0.0055 0.0453 0.0667
Schistosoma mansoni regulator of G protein signaling 0.0018 0.0049 0.0049
Brugia malayi RE15519p 0.0039 0.0287 0.071
Echinococcus multilocularis Polycystic kidney disease protein 0.0036 0.0253 0.0372

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 0.69 nM Displacement of [125I]TZDM from human beta amyloid fibril 1-42 ChEMBL. 17544669

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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