Detailed information for compound 1000888

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 471.885 | Formula: C23H15ClFNO5S
  • H donors: 1 H acceptors: 5 LogP: 5.99 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1ccc(cc1)CS/C(=C/c1ccc(c(c1)[N+](=O)[O-])F)/C(=O)c1ccc(cc1)C(=O)O
  • InChi: 1S/C23H15ClFNO5S/c24-18-8-1-14(2-9-18)13-32-21(12-15-3-10-19(25)20(11-15)26(30)31)22(27)16-4-6-17(7-5-16)23(28)29/h1-12H,13H2,(H,28,29)/b21-12+
  • InChiKey: QMOGFTXYFWPGAL-CIAFOILYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens breakpoint cluster region Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus active breakpoint cluster region Get druggable targets OG5_131841 All targets in OG5_131841
Echinococcus multilocularis active breakpoint cluster region Get druggable targets OG5_131841 All targets in OG5_131841
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major ATP-binding cassette protein subfamily B, member 2, putative 0.001 0.0019 0.0221
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.002 0.002
Schistosoma mansoni aldo-keto reductase 0.0064 0.0424 0.0424
Treponema pallidum sodium- and chloride- dependent transporter 0.1316 1 1
Trichomonas vaginalis aldo-keto reductase, putative 0.0064 0.0424 0.2033
Entamoeba histolytica aldose reductase, putative 0.0064 0.0424 1
Trypanosoma cruzi cytochrome P450, putative 0.0013 0.0036 0.0839
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0011 0.002 0.002
Trypanosoma cruzi DNA polymerase kappa, putative 0.0042 0.0262 0.6184
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0262 0.6184
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0015 0.0053 0.0053
Echinococcus granulosus caspase 0.0121 0.0861 0.0861
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0011 0.002 0.002
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.0223 0.1647 1
Loa Loa (eye worm) hypothetical protein 0.0042 0.0263 0.0263
Schistosoma mansoni sodium/chloride dependent transporter 0.0223 0.1647 0.1647
Echinococcus multilocularis microtubule associated protein 2 0.0712 0.538 0.538
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.0223 0.1647 0.1647
Entamoeba histolytica aldose reductase, putative 0.0064 0.0424 1
Schistosoma mansoni sex comb on midleg homolog 0.0049 0.0314 0.0314
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0064 0.0424 0.2033
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0197 0.1446 0.1446
Loa Loa (eye worm) hypothetical protein 0.0223 0.1647 0.1647
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0011 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.0049 0.0314 0.0314
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.002 0.002
Echinococcus granulosus 5'partial|ATP binding cassette sub family B 0.001 0.0018 0.0018
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0015 0.0053 0.0053
Onchocerca volvulus 0.0049 0.0314 0.0314
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.0223 0.1647 0.1647
Echinococcus granulosus histone acetyltransferase MYST2 0.0056 0.0365 0.0365
Echinococcus granulosus potassium voltage gated channel subfamily A 0.0097 0.0679 0.0679
Entamoeba histolytica P-glycoprotein-5 0.001 0.0019 0.0443
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0046 0.0287 0.1377
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0064 0.0424 0.0424
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0011 0.002 0.002
Onchocerca volvulus 0.0014 0.0046 0.0046
Brugia malayi ABC transporter family protein 0.001 0.0019 0.0019
Plasmodium falciparum transporter, putative 0.0223 0.1647 1
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.0287 0.1377
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0087 0.2048
Trypanosoma brucei DNA polymerase IV, putative 0.0036 0.021 0.4958
Plasmodium falciparum metacaspase-like protein 0.0046 0.0287 0.1746
Loa Loa (eye worm) hypothetical protein 0.001 0.0019 0.0019
Brugia malayi PAN domain containing protein 0.0014 0.0046 0.0046
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0011 0.0026 0.0158
Leishmania major aldo-keto reductase-like protein 0.0064 0.0424 0.4988
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0011 0.002 0.002
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.001 0.0019 0.0019
Trichomonas vaginalis aldo-keto reductase, putative 0.0064 0.0424 0.2033
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.0056 0.0365 0.0365
Loa Loa (eye worm) oxidoreductase 0.0064 0.0424 0.0424
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0064 0.0424 0.0424
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0223 0.1647 0.1647
Leishmania major metacaspase, putative 0.0046 0.0287 0.3379
Onchocerca volvulus Bile acid receptor homolog 0.0011 0.002 0.002
Schistosoma mansoni hypothetical protein 0.0174 0.1271 0.1271
Trichomonas vaginalis aldo-keto reductase, putative 0.0064 0.0424 0.2033
Schistosoma mansoni RAR-like nuclear receptor 0.0011 0.002 0.002
Toxoplasma gondii microneme protein MIC17A 0.0014 0.0046 0.0278
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0262 0.6184
Trypanosoma brucei DNA polymerase eta, putative 0.0015 0.0053 0.1243
Schistosoma mansoni hypothetical protein 0.0022 0.0104 0.0104
Trypanosoma cruzi metacaspase, putative 0.0046 0.0287 0.6774
Toxoplasma gondii exonuclease III APE 0.0019 0.0087 0.0528
Plasmodium vivax oxidoreductase, aldo/keto reductase domain containing protein 0.0018 0.0079 0.0482
Echinococcus multilocularis aldo keto reductase 0.0064 0.0424 0.0424
Echinococcus multilocularis histone acetyltransferase MYST2 0.0056 0.0365 0.0365
Echinococcus multilocularis SAM and MBT domain containing protein 0.0049 0.0314 0.0314
Trichomonas vaginalis aldo/keto reductase, putative 0.0064 0.0424 0.2033
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0011 0.002 0.002
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0046 0.0287 0.1746
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0064 0.0424 0.0424
Schistosoma mansoni glutaminase 0.0281 0.2088 0.2088
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0046 0.0287 0.1746
Trypanosoma brucei DNA polymerase kappa, putative 0.0017 0.0069 0.1634
Echinococcus multilocularis ATP binding cassette sub family B 0.001 0.0018 0.0018
Brugia malayi PAN domain containing protein 0.0014 0.0046 0.0046
Mycobacterium ulcerans DNA polymerase IV 0.0042 0.0262 0.1257
Mycobacterium tuberculosis Probable transmembrane multidrug efflux pump 0.001 0.0019 0.0221
Schistosoma mansoni hypothetical protein 0.0042 0.0263 0.0263
Onchocerca volvulus 0.0064 0.0424 0.0424
Trichomonas vaginalis aldo-keto reductase, putative 0.0018 0.0079 0.038
Giardia lamblia Aldose reductase 0.0064 0.0424 1
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0011 0.002 0.002
Echinococcus multilocularis caspase 2 0.0088 0.0612 0.0612
Schistosoma mansoni caspase-7 (C14 family) 0.0121 0.0861 0.0861
Trichomonas vaginalis DNA polymerase eta, putative 0.0042 0.0262 0.1257
Mycobacterium ulcerans oxidoreductase 0.0064 0.0424 0.2033
Trichomonas vaginalis aldo-keto reductase, putative 0.0064 0.0424 0.2033
Echinococcus granulosus SAM and MBT domain containing protein 0.0049 0.0314 0.0314
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0223 0.1647 0.1647
Brugia malayi mbt repeat family protein 0.0049 0.0314 0.0314
Echinococcus multilocularis potassium voltage gated channel subfamily A 0.0093 0.0647 0.0647
Entamoeba histolytica alcohol dehydrogenase, putative 0.0018 0.0079 0.1869
Echinococcus granulosus multidrug resistance protein 1 0.001 0.0019 0.0019
Trypanosoma brucei DNA polymerase kappa, putative 0.0017 0.0069 0.1634
Loa Loa (eye worm) hypothetical protein 0.001 0.0018 0.0018
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0262 0.6184
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0011 0.002 0.002
Loa Loa (eye worm) glutaminase 0.0281 0.2088 0.2088
Brugia malayi Kringle domain containing protein 0.0022 0.0104 0.0104
Brugia malayi PAN domain containing protein 0.0014 0.0046 0.0046
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0223 0.1647 0.1647
Toxoplasma gondii kringle domain-containing protein 0.0022 0.0104 0.0634
Entamoeba histolytica P-glycoprotein 5, putative 0.001 0.0019 0.0443
Loa Loa (eye worm) hypothetical protein 0.1316 1 1
Onchocerca volvulus 0.0014 0.0046 0.0046
Trichomonas vaginalis alcohol dehydrogenase, putative 0.0018 0.0079 0.038
Entamoeba histolytica P-glycoprotein-1 0.001 0.0019 0.0443
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0011 0.002 0.002
Brugia malayi NADH-dependent xylose reductase 0.0018 0.0079 0.0079
Brugia malayi polk-prov protein 0.0032 0.0184 0.0184
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0087 1
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0087 0.0087
Onchocerca volvulus 0.0223 0.1647 0.1647
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0046 0.0287 0.1377
Brugia malayi hypothetical protein 0.0042 0.0263 0.0263
Plasmodium vivax multidrug resistance protein 1, putative 0.001 0.0019 0.0114
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0087 0.0416
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.002 0.002
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.001 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0014 0.0046 0.0046
Loa Loa (eye worm) hypothetical protein 0.0011 0.002 0.002
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0046 0.0287 0.1377
Echinococcus multilocularis aldo keto reductase 0.0064 0.0424 0.0424
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.0121 0.0861 0.0861
Trypanosoma cruzi DNA polymerase kappa, putative 0.0042 0.0262 0.6184
Loa Loa (eye worm) hypothetical protein 0.0011 0.002 0.002
Mycobacterium ulcerans glutaminase 0.0281 0.2088 1
Schistosoma mansoni pol-related 0.0064 0.0424 0.0424
Loa Loa (eye worm) hypothetical protein 0.0014 0.0046 0.0046
Trypanosoma cruzi aldo/keto reductase, putative 0.0064 0.0424 1
Brugia malayi Protein kinase domain containing protein 0.0022 0.0104 0.0104
Loa Loa (eye worm) hypothetical protein 0.0011 0.002 0.002
Schistosoma mansoni myelin transcription factor 1 myt1 0.0056 0.0365 0.0365
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0079 0.038
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0064 0.0424 0.0424
Brugia malayi steroid hormone receptor 0.0011 0.002 0.002
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.001 0.0019 0.009
Echinococcus granulosus sodium and chloride dependent glycine 0.0223 0.1647 0.1647
Echinococcus granulosus aldo keto reductase 0.0064 0.0424 0.0424
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0262 0.6184
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0087 0.1021
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.002 0.002
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0064 0.0424 0.0424
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0087 0.0087
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0223 0.1647 0.1647
Loa Loa (eye worm) hypothetical protein 0.0223 0.1647 0.1647
Trichomonas vaginalis abcb9, putative 0.001 0.0019 0.009
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0064 0.0424 0.0424
Trypanosoma brucei unspecified product 0.001 0.0017 0.0408
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0064 0.0424 0.0424
Echinococcus multilocularis multidrug resistance protein 1 0.001 0.0019 0.0019
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0011 0.002 0.002
Toxoplasma gondii PAN domain-containing protein 0.0014 0.0046 0.0278
Loa Loa (eye worm) hypothetical protein 0.0014 0.0046 0.0046
Echinococcus granulosus potassium voltage gated channel protein 0.0097 0.0679 0.0679
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0223 0.1647 0.1647
Onchocerca volvulus 0.0014 0.0046 0.0046
Toxoplasma gondii PAN domain-containing protein 0.0014 0.0046 0.0278
Echinococcus multilocularis tissue type plasminogen activator 0.0022 0.0104 0.0104
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0056 0.0365 0.0365
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0022 0.0104 0.0634
Echinococcus multilocularis sodium and chloride dependent glycine 0.0223 0.1647 0.1647
Echinococcus multilocularis dna polymerase kappa 0.0042 0.0262 0.0262
Toxoplasma gondii microneme protein MIC17C 0.0014 0.0046 0.0278
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0011 0.002 0.002
Trypanosoma cruzi DNA polymerase eta, putative 0.0015 0.0053 0.1243
Echinococcus multilocularis active breakpoint cluster region 0.0122 0.087 0.087
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0064 0.0424 0.0424
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0087 0.0416
Brugia malayi Cytochrome P450 family protein 0.0013 0.0036 0.0036
Echinococcus granulosus tissue type plasminogen activator 0.0022 0.0104 0.0104
Plasmodium vivax hypothetical protein, conserved 0.0223 0.1647 1
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0064 0.0424 0.0424
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0223 0.1647 0.1647
Trypanosoma brucei metacaspase 0.0046 0.0287 0.6774
Loa Loa (eye worm) hypothetical protein 0.0011 0.002 0.002
Schistosoma mansoni voltage-gated potassium channel 0.0097 0.0679 0.0679
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.002 0.002
Brugia malayi PAN domain containing protein 0.0014 0.0046 0.0046
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0111 0.0789 0.0789
Mycobacterium leprae Conserved hypothetical protein 0.0045 0.0284 0.6684
Toxoplasma gondii aldo/keto reductase family oxidoreductase 0.0018 0.0079 0.0482
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0064 0.0424 0.0424
Loa Loa (eye worm) hypothetical protein 0.0088 0.0612 0.0612
Brugia malayi PAN domain containing protein 0.0014 0.0046 0.0046
Loa Loa (eye worm) glutaminase 2 0.0281 0.2088 0.2088
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0046 0.0287 0.1377
Trypanosoma cruzi metacaspase 5, putative 0.0046 0.0287 0.6774
Plasmodium falciparum aldehyde reductase, putative 0.0018 0.0079 0.0482
Echinococcus granulosus voltage gated potassium channel subunit 0.0018 0.0079 0.0079
Loa Loa (eye worm) hypothetical protein 0.0011 0.002 0.002
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0011 0.002 0.002
Plasmodium vivax hypothetical protein, conserved 0.0046 0.0287 0.1746
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0119 0.0851 0.0851
Echinococcus granulosus caspase 3 0.0075 0.0512 0.0512
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0087 0.0528
Echinococcus multilocularis caspase 8 0.0046 0.0287 0.0287
Loa Loa (eye worm) hypothetical protein 0.0223 0.1647 0.1647
Loa Loa (eye worm) mbt repeat family protein 0.0049 0.0314 0.0314
Loa Loa (eye worm) hypothetical protein 0.1316 1 1
Toxoplasma gondii microneme protein MIC4 0.0014 0.0046 0.0278
Echinococcus multilocularis multidrug resistance protein 1 0.001 0.0019 0.0019
Loa Loa (eye worm) oxidoreductase 0.0064 0.0424 0.0424
Onchocerca volvulus 0.0042 0.0263 0.0263
Onchocerca volvulus 0.0014 0.0046 0.0046
Brugia malayi ecdysteroid receptor 0.0011 0.002 0.002
Trichomonas vaginalis ABC transporter, putative 0.001 0.0019 0.009
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0262 0.6184
Entamoeba histolytica aldose reductase, putative 0.0064 0.0424 1
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0049 0.0314 0.0314
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.001 0.0019 0.0019
Schistosoma mansoni hypothetical protein 0.0302 0.2248 0.2248
Toxoplasma gondii subtilisin SUB12 0.0014 0.0046 0.0278
Loa Loa (eye worm) oxidoreductase 0.0064 0.0424 0.0424
Brugia malayi PAN domain containing protein 0.0014 0.0046 0.0046
Loa Loa (eye worm) hypothetical protein 0.0011 0.002 0.002
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.001 0.0019 0.009
Onchocerca volvulus 0.0223 0.1647 0.1647
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.1316 1 1
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0223 0.1647 0.1647
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.0011 0.002 0.002
Leishmania major DNA polymerase kappa, putative 0.0022 0.0105 0.1231
Onchocerca volvulus 0.0064 0.0424 0.0424
Onchocerca volvulus 0.0064 0.0424 0.0424
Trypanosoma brucei Metacaspase-4 0.0046 0.0287 0.6774
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.001 0.0019 0.0019
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.001 0.0019 0.0019
Echinococcus granulosus multidrug resistance protein 1 0.001 0.0019 0.0019
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0223 0.1647 0.1647
Trypanosoma brucei DNA polymerase kappa, putative 0.0017 0.0069 0.1634
Loa Loa (eye worm) hypothetical protein 0.0097 0.0679 0.0679
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.001 0.0019 0.009
Trypanosoma cruzi aldo-keto reductase 0.0064 0.0424 1
Echinococcus granulosus apoptotic protease activating factor 1 0.0042 0.0263 0.0263
Trichomonas vaginalis aldo-keto reductase, putative 0.0018 0.0079 0.038
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0087 0.0416
Trichomonas vaginalis aldo-keto reductase, putative 0.0064 0.0424 0.2033
Loa Loa (eye worm) PAN domain-containing protein 0.0014 0.0046 0.0046
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.002 0.002
Trypanosoma cruzi metacaspase, putative 0.0046 0.0287 0.6774
Trichomonas vaginalis taga, putative 0.001 0.0019 0.009
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0119 0.0851 0.0851
Entamoeba histolytica P-glycoprotein-2 0.001 0.0019 0.0443
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.001 0.0019 0.009
Onchocerca volvulus 0.0223 0.1647 0.1647
Trichomonas vaginalis aldo-keto reductase, putative 0.0064 0.0424 0.2033
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.001 0.0019 0.009
Brugia malayi Steroid receptor seven-up type 2 0.0011 0.002 0.002
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0087 0.2048
Brugia malayi mucosa associated lymphoid tissue lymphoma translocation protein 1 0.0046 0.0287 0.0287
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.0223 0.1647 0.1647
Giardia lamblia Aldose reductase 0.0064 0.0424 1
Loa Loa (eye worm) ATP-binding cassette sub-family B member 2 0.001 0.0019 0.0019
Trichomonas vaginalis glutaminase, putative 0.0281 0.2088 1
Brugia malayi PAN domain containing protein 0.0014 0.0046 0.0046
Leishmania major hypothetical protein, conserved 0.0022 0.0104 0.1227
Echinococcus granulosus sodium and chloride dependent glycine 0.0223 0.1647 0.1647
Trypanosoma brucei metacaspase MCA2 0.0046 0.0287 0.6774
Schistosoma mansoni aldo-keto reductase 0.0064 0.0424 0.0424
Trypanosoma brucei metacaspase MCA3 0.0046 0.0287 0.6774
Entamoeba histolytica P-glycoprotein-2 0.001 0.0019 0.0443
Schistosoma mansoni thyroid hormone receptor 0.0011 0.002 0.002
Plasmodium vivax metacaspase 1, putative 0.0046 0.0287 0.1746
Giardia lamblia DINP protein human, muc B family 0.0022 0.0105 0.2469
Schistosoma mansoni caspase-3 (C14 family) 0.0121 0.0861 0.0861
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0223 0.1647 1
Trypanosoma brucei aldo-keto reductase, putative 0.0064 0.0424 1
Echinococcus multilocularis sodium and chloride dependent glycine 0.0223 0.1647 0.1647
Loa Loa (eye worm) oxidoreductase 0.0064 0.0424 0.0424
Schistosoma mansoni thyroid hormone receptor 0.0011 0.002 0.002
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0011 0.002 0.002
Entamoeba histolytica P-glyco protein 6, putative 0.001 0.0019 0.0443
Trypanosoma brucei DNA polymerase IV, putative 0.0042 0.0262 0.6184
Loa Loa (eye worm) hypothetical protein 0.0032 0.0184 0.0184
Entamoeba histolytica P-glycoprotein-2, putative 0.001 0.0019 0.0443
Brugia malayi photoreceptor-specific nuclear receptor 0.0011 0.002 0.002
Brugia malayi PAN domain containing protein 0.0014 0.0046 0.0046
Leishmania major aldo/keto reductase, putative,aldo/keto reductase family-like protein 0.0018 0.0079 0.0932
Trichomonas vaginalis ABC transporter, putative 0.001 0.0019 0.009
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0087 0.1021
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0262 0.6184
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0262 0.6184
Loa Loa (eye worm) hypothetical protein 0.0011 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.0009 0.0008 0.0008
Echinococcus multilocularis thyroid hormone receptor alpha 0.0011 0.002 0.002
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0064 0.0424 0.0424
Trypanosoma cruzi metacaspase, putative 0.0046 0.0287 0.6774
Schistosoma mansoni sodium/chloride dependent transporter 0.0223 0.1647 0.1647
Brugia malayi ImpB/MucB/SamB family protein 0.0015 0.0053 0.0053
Trypanosoma cruzi DNA polymerase kappa, putative 0.0042 0.0262 0.6184
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0011 0.002 0.002
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.001 0.0019 0.009
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0223 0.1647 0.1647
Loa Loa (eye worm) hypothetical protein 0.0046 0.0287 0.0287
Loa Loa (eye worm) hypothetical protein 0.0022 0.0104 0.0104
Schistosoma mansoni retinoic acid receptor RXR 0.0011 0.002 0.002
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0013 0.0036 0.017
Toxoplasma gondii PAN domain-containing protein 0.0014 0.0046 0.0278
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0119 0.0851 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0032 0.0184 0.4329
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.001 0.0019 0.0019
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0046 0.0287 0.1746
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.001 0.0019 0.0019
Echinococcus granulosus dna polymerase kappa 0.0042 0.0262 0.0262
Brugia malayi Cytochrome P450 family protein 0.0013 0.0036 0.0036
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0011 0.002 0.002
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.001 0.0019 0.009
Brugia malayi nuclear hormone receptor 0.0011 0.002 0.002
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0011 0.002 0.002
Trichomonas vaginalis aldo-keto reductase, putative 0.0064 0.0424 0.2033
Onchocerca volvulus Protein ultraspiracle homolog 0.0011 0.002 0.002
Echinococcus multilocularis voltage gated potassium channel subunit 0.0018 0.0079 0.0079
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.001 0.0019 0.0019
Echinococcus multilocularis aldo keto reductase 0.0064 0.0424 0.0424
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.001 0.0019 0.009
Echinococcus granulosus microtubule associated protein 2 0.0712 0.538 0.538
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0064 0.0424 0.0424
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.001 0.0019 0.009
Toxoplasma gondii aldose reductase, putative 0.0064 0.0424 0.2577
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.0287 0.1377
Trypanosoma cruzi hypothetical protein, conserved 0.0022 0.0104 0.246
Echinococcus granulosus aldo keto reductase 0.0064 0.0424 0.0424
Trypanosoma brucei DNA polymerase kappa, putative 0.0032 0.0184 0.4329
Echinococcus multilocularis apoptotic protease activating factor 1 0.0042 0.0263 0.0263
Schistosoma mansoni potassium channel beta 0.0018 0.0079 0.0079
Loa Loa (eye worm) MBCTL1 0.0056 0.0365 0.0365
Echinococcus granulosus hypothetical protein 0.0064 0.0424 0.0424
Trypanosoma cruzi cytochrome P450, putative 0.0013 0.0036 0.0839
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0011 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.0223 0.1647 0.1647
Echinococcus granulosus multidrug resistance protein 1 0.001 0.0019 0.0019
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0011 0.002 0.002
Onchocerca volvulus 0.001 0.0019 0.0019
Plasmodium falciparum metacaspase 1 0.0046 0.0287 0.1746
Loa Loa (eye worm) multidrug resistance protein 3 0.001 0.0019 0.0019
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0011 0.002 0.002
Trypanosoma cruzi metacaspase 5, putative 0.0046 0.0287 0.6774
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0223 0.1647 0.1647
Leishmania major cytochrome p450-like protein 0.0013 0.0036 0.0418
Brugia malayi ImpB/MucB/SamB family protein 0.0015 0.0053 0.0053
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.001 0.0019 0.009
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0011 0.002 0.002
Loa Loa (eye worm) PAN domain-containing protein 0.0014 0.0046 0.0046
Trichomonas vaginalis aldo-keto reductase, putative 0.0064 0.0424 0.2033
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0223 0.1647 0.1647
Echinococcus granulosus ecdysone induced protein 78C 0.0011 0.002 0.002
Toxoplasma gondii microneme protein, putative 0.0014 0.0046 0.0278
Echinococcus granulosus FTZ F1 alpha 0.0011 0.002 0.002
Leishmania major prostaglandin f2-alpha synthase/D-arabinose dehydrogenase 0.0064 0.0424 0.4988
Mycobacterium leprae Possible oxidoreductase 0.0018 0.0079 0.1869
Trypanosoma brucei cytochrome P450, putative 0.0013 0.0036 0.0839
Mycobacterium ulcerans hypothetical protein 0.0018 0.0079 0.038
Trypanosoma brucei unspecified product 0.001 0.0017 0.0408
Leishmania major DNA polymerase eta, putative 0.0015 0.0053 0.062
Toxoplasma gondii oxidoreductase, aldo/keto reductase family protein 0.0018 0.0079 0.0482
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0011 0.002 0.002
Onchocerca volvulus 0.0022 0.0104 0.0104
Brugia malayi nuclear receptor NHR-88 0.0011 0.002 0.002
Brugia malayi PAN domain containing protein 0.0014 0.0046 0.0046
Brugia malayi hypothetical protein 0.0223 0.1647 0.1647
Onchocerca volvulus 0.0014 0.0046 0.0046
Loa Loa (eye worm) hypothetical protein 0.0014 0.0046 0.0046
Loa Loa (eye worm) PAN domain-containing protein 0.0014 0.0046 0.0046
Toxoplasma gondii hypothetical protein 0.0223 0.1647 1
Schistosoma mansoni smdr2 0.001 0.0019 0.0019
Onchocerca volvulus 0.1316 1 1
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0087 0.0528
Schistosoma mansoni caspase-7 (C14 family) 0.0088 0.0612 0.0612
Trypanosoma brucei unspecified product 0.0036 0.021 0.4958
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0049 0.0314 0.0314
Leishmania major p-glycoprotein 0.001 0.0019 0.0221
Onchocerca volvulus Cell death protein 3 homolog 0.0088 0.0612 0.0612
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0087 0.2048
Mycobacterium tuberculosis Conserved hypothetical protein 0.0015 0.0053 0.062
Trichomonas vaginalis abcb9, putative 0.001 0.0019 0.009
Echinococcus granulosus caspase 2 0.0088 0.0612 0.0612
Echinococcus multilocularis aldehyde reductase 0.0045 0.0284 0.0284
Trichomonas vaginalis aldo/keto reductase, putative 0.0064 0.0424 0.2033
Loa Loa (eye worm) solute carrier family 6 member 4 0.1316 1 1
Onchocerca volvulus 0.0064 0.0424 0.0424
Toxoplasma gondii hypothetical protein 0.0014 0.0046 0.0278
Brugia malayi mbt repeat family protein 0.0049 0.0314 0.0314
Onchocerca volvulus 0.0014 0.0046 0.0046
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.001 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.1316 1 1
Echinococcus granulosus active breakpoint cluster region 0.0122 0.087 0.087
Loa Loa (eye worm) steroid hormone receptor 0.0011 0.002 0.002
Schistosoma mansoni sodium/chloride dependent transporter 0.1316 1 1
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0064 0.0424 0.0424
Toxoplasma gondii aldo-keto reductase 0.0018 0.0079 0.0482
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0064 0.0424 0.0424
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0022 0.0105 0.1231
Toxoplasma gondii PAN domain-containing protein 0.0014 0.0046 0.0278
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0223 0.1647 0.1647
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0011 0.002 0.002
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0119 0.0851 0.4075
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0064 0.0424 0.0424
Toxoplasma gondii PAN/Apple domain-containing protein 0.0014 0.0046 0.0278
Loa Loa (eye worm) serotonin transporter b 0.1316 1 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.002 0.002
Echinococcus multilocularis aldo keto reductase 0.0064 0.0424 0.0424
Loa Loa (eye worm) hypothetical protein 0.0223 0.1647 0.1647
Leishmania major prostaglandin f synthase, putative 0.0064 0.0424 0.4988
Onchocerca volvulus 0.0014 0.0046 0.0046
Echinococcus granulosus aldo keto reductase family 1, member B4 0.0018 0.0079 0.0079
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0011 0.002 0.002
Loa Loa (eye worm) norepinephrine transporter 0.1316 1 1
Trypanosoma brucei aldo/keto reductase, putative 0.0018 0.0079 0.1869
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.0223 0.1647 0.1647
Onchocerca volvulus 0.0014 0.0046 0.0046
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0022 0.0105 0.1231
Echinococcus multilocularis potassium voltage gated channel protein 0.0097 0.0679 0.0679
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0087 0.2048
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0056 0.0365 0.0365
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0064 0.0424 0.0424
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0064 0.0424 0.0424
Trypanosoma brucei metacaspase 5, putative 0.0046 0.0287 0.6774
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.001 0.0019 0.009
Trichomonas vaginalis aldo-keto reductase, putative 0.0064 0.0424 0.2033
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0223 0.1647 0.1647
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.002 0.002
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0046 0.0287 0.1377
Toxoplasma gondii ATP-binding cassette transporter ABC.B1 0.001 0.0019 0.0114
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0223 0.1647 1
Schistosoma mansoni subfamily C14A unassigned peptidase (C14 family) 0.0046 0.0287 0.0287
Schistosoma mansoni sodium-dependent amino acid transporter 0.0223 0.1647 0.1647
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0087 0.2048
Toxoplasma gondii microneme protein MIC17B 0.0014 0.0046 0.0278
Mycobacterium ulcerans DNA polymerase IV 0.0042 0.0262 0.1257
Echinococcus granulosus aldo keto reductase 0.0064 0.0424 0.0424
Onchocerca volvulus 0.0014 0.0046 0.0046
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0087 0.0087
Echinococcus granulosus serotonin transporter 0.1316 1 1
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0046 0.0287 0.1377
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0011 0.002 0.002
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0011 0.002 0.002
Echinococcus granulosus geminin 0.0174 0.1271 0.1271
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0064 0.0424 0.0424
Entamoeba histolytica alcohol dehydrogenase, putative 0.0018 0.0079 0.1869
Echinococcus multilocularis dna polymerase eta 0.0015 0.0053 0.0053
Echinococcus multilocularis serotonin transporter 0.1316 1 1
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0056 0.0365 0.0365
Loa Loa (eye worm) hypothetical protein 0.0014 0.0046 0.0046
Onchocerca volvulus 0.0011 0.002 0.002
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0011 0.002 0.002
Trichomonas vaginalis aldo-keto reductase, putative 0.0064 0.0424 0.2033
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0223 0.1647 0.1647
Plasmodium falciparum aldo-keto reductase, putative 0.0018 0.0079 0.0482
Echinococcus multilocularis caspase 0.0121 0.0861 0.0861
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0119 0.0851 0.0851
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.0223 0.1647 0.1647
Schistosoma mansoni ap endonuclease 0.0019 0.0087 0.0087
Toxoplasma gondii 1,3(4)-beta-glucanase 0.0014 0.0046 0.0278
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.0287 0.1377
Echinococcus multilocularis polycomb protein SCMH1 0.0049 0.0314 0.0314
Mycobacterium tuberculosis Conserved protein 0.0018 0.0079 0.0932
Loa Loa (eye worm) CYP4Cod1 0.0013 0.0036 0.0036
Brugia malayi glutaminase DH11.1 0.0281 0.2088 0.2088
Trichomonas vaginalis ABC transporter, putative 0.001 0.0019 0.009
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.001 0.0019 0.0114
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.0223 0.1647 0.1647
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0046 0.0287 0.1377
Echinococcus granulosus polycomb protein SCMH1 0.0049 0.0314 0.0314
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.001 0.0019 0.009
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0046 0.0287 0.1377
Onchocerca volvulus 0.0064 0.0424 0.0424
Loa Loa (eye worm) TK/ROR protein kinase 0.0022 0.0104 0.0104
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.001 0.0019 0.009
Loa Loa (eye worm) hypothetical protein 0.0014 0.0046 0.0046
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.002 0.002
Schistosoma mansoni sex comb on midleg homolog 0.0049 0.0314 0.0314
Trypanosoma cruzi DNA polymerase kappa, putative 0.0042 0.0262 0.6184
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0011 0.002 0.002
Plasmodium vivax aldehyde reductase, putative 0.0018 0.0079 0.0482
Schistosoma mansoni multidrug resistance protein 0.001 0.0019 0.0019
Plasmodium vivax amine transporter, putative 0.0223 0.1647 1
Loa Loa (eye worm) PAN domain-containing protein 0.0014 0.0046 0.0046
Onchocerca volvulus 0.0064 0.0424 0.0424
Schistosoma mansoni terminal deoxycytidyl transferase 0.0015 0.0053 0.0053
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0262 0.6184
Brugia malayi Voltage-gated potassium channel, Shaker-family (KCNA, Kv1-like) alpha-subunit 0.0097 0.0679 0.0679
Plasmodium falciparum amino acid transporter, putative 0.0223 0.1647 1
Trypanosoma brucei DNA polymerase IV, putative 0.0042 0.0262 0.6184
Echinococcus multilocularis caspase 3 0.0075 0.0512 0.0512
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0046 0.0287 0.1377
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.0287 0.1377
Echinococcus multilocularis FTZ F1 alpha 0.0011 0.002 0.002
Mycobacterium leprae PROBABLE OXIDOREDUCTASE 0.0064 0.0424 1
Schistosoma mansoni multidrug resistance protein 0.001 0.0019 0.0019
Toxoplasma gondii PAN domain-containing protein 0.0014 0.0046 0.0278
Schistosoma mansoni steroid hormone receptor ad4bp 0.0011 0.002 0.002
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.0121 0.0861 0.0861
Brugia malayi Cell death protein 3 precursor 0.0088 0.0612 0.0612
Schistosoma mansoni microtubule-associated protein tau 0.0712 0.538 0.538
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0119 0.0851 0.0851
Echinococcus multilocularis geminin 0.0174 0.1271 0.1271
Loa Loa (eye worm) cytochrome P450 family protein 0.0013 0.0036 0.0036
Schistosoma mansoni multidrug resistance protein 0.001 0.0019 0.0019
Schistosoma mansoni ap endonuclease 0.0019 0.0087 0.0087
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0064 0.0424 0.0424
Trichomonas vaginalis aldo-keto reductase, putative 0.0064 0.0424 0.2033
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0262 0.6184
Echinococcus granulosus caspase 8 0.0046 0.0287 0.0287
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.001 0.0019 0.009
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.001 0.0019 0.009
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0042 0.0262 0.1257
Trypanosoma cruzi metacaspase, putative 0.0046 0.0287 0.6774
Onchocerca volvulus 0.0014 0.0046 0.0046
Leishmania major aldehyde reductase, putative,oxidoreductase, putative 0.0064 0.0424 0.4988
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.0287 0.1377
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0223 0.1647 1
Onchocerca volvulus 0.0018 0.0079 0.0079
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0011 0.002 0.002
Toxoplasma gondii hypothetical protein 0.0223 0.1647 1
Schistosoma mansoni DNA polymerase eta 0.0015 0.0053 0.0053
Mycobacterium tuberculosis Probable oxidoreductase 0.0064 0.0424 0.4988
Loa Loa (eye worm) hypothetical protein 0.001 0.0019 0.0019
Schistosoma mansoni coup transcription factor 0.0011 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.0223 0.1647 0.1647
Echinococcus multilocularis ecdysone induced protein 78C 0.0011 0.002 0.002
Entamoeba histolytica deoxycytidyl transferase, putative 0.0015 0.0053 0.1243
Trichomonas vaginalis ABC transporter, half transporter, putative 0.001 0.0019 0.009
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0064 0.0424 0.0424
Trypanosoma brucei prostaglandin f synthase 0.0064 0.0424 1
Trichomonas vaginalis ABC transporter, putative 0.001 0.0019 0.009
Plasmodium falciparum multidrug resistance protein 1 0.001 0.0019 0.0114
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0015 0.0053 0.0053
Brugia malayi glutamate-cysteine ligase modifier subunit 0.0018 0.0079 0.0079
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0015 0.0053 0.0053
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0064 0.0424 0.2033
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.001 0.0019 0.009
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0064 0.0424 0.0424
Loa Loa (eye worm) hypothetical protein 0.0064 0.0424 0.0424
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0011 0.002 0.002
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0087 0.0087
Brugia malayi multidrug resistance protein 3 0.001 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0014 0.0046 0.0046
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0011 0.002 0.002
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.001 0.0019 0.009
Trichomonas vaginalis aldo-keto reductase, putative 0.0064 0.0424 0.2033
Loa Loa (eye worm) hypothetical protein 0.0015 0.0053 0.0053
Loa Loa (eye worm) hypothetical protein 0.0223 0.1647 0.1647
Loa Loa (eye worm) cytochrome P450 family protein 0.0013 0.0036 0.0036
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0064 0.0424 0.0424
Loa Loa (eye worm) glutamate-cysteine ligase modifier subunit 0.0018 0.0079 0.0079
Loa Loa (eye worm) oxidoreductase 0.0064 0.0424 0.0424
Trichomonas vaginalis abcb9, putative 0.001 0.0019 0.009
Trichomonas vaginalis ABC transporter, half transporter, putative 0.001 0.0019 0.009
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.001 0.0019 0.009
Trypanosoma cruzi aldo/keto reductase, putative 0.0018 0.0079 0.1869
Schistosoma mansoni hypothetical protein 0.0174 0.1271 0.1271
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.001 0.0019 0.009
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0064 0.0424 0.0424
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0119 0.0851 0.4075
Trichomonas vaginalis aldo/keto reductase, putative 0.0064 0.0424 0.2033
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0197 0.1446 0.1446
Echinococcus granulosus aldehyde reductase 0.0045 0.0284 0.0284
Schistosoma mansoni nuclear hormone receptor 0.0011 0.002 0.002
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.001 0.0019 0.009
Plasmodium falciparum cysteine repeat modular protein 1 0.0022 0.0104 0.0634
Toxoplasma gondii PAN domain-containing protein 0.0014 0.0046 0.0278
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0105 0.2469
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0064 0.0424 0.2033
Trichomonas vaginalis aldo-keto reductase, putative 0.0018 0.0079 0.038
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0119 0.0851 1
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.0287 0.1377
Onchocerca volvulus 0.0014 0.0046 0.0046
Brugia malayi PAN domain containing protein 0.0014 0.0046 0.0046
Toxoplasma gondii hypothetical protein 0.0014 0.0046 0.0278
Loa Loa (eye worm) PAN domain-containing protein 0.0014 0.0046 0.0046
Echinococcus granulosus dna polymerase eta 0.0015 0.0053 0.0053
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0064 0.0424 0.0424
Schistosoma mansoni voltage-gated potassium channel 0.0097 0.0679 0.0679
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0223 0.1647 0.1647

Activities

Activity type Activity value Assay description Source Reference
GI50 (functional) = 10 uM Growth inhibition of human K562 cells expressing p210Bcr/Abl after 96 hrs by trypan blue exclusion assay ChEMBL. 20188579
GI50 (functional) = 50 uM Growth inhibition of human DU145 cells after 96 hrs by trypan blue exclusion assay ChEMBL. 20188579
IC50 (functional) = 0.5 uM Growth inhibition of human K562 cells expressing p210Bcr/Abl after 96 hrs by trypan blue exclusion assay ChEMBL. 20188579
IC50 (binding) = 2.5 uM Inhibition of BCR/ABL p210 autophosphorylation in human K562 cells after 2 hrs by Western blot analysis ChEMBL. 20188579

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23 20188579

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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