Detailed information for compound 1003153

Basic information

Technical information
  • TDR Targets ID: 1003153
  • Name: (4aR,5R,6aR,6aS,6bR,8aR,10S,12aR,14bS)-10-[(2 S,3R,4S,5S)-3-[(2S,3R,4R,5S,6S)-3,5-dihydroxy -6-methyl-4-[(2S,3R,4S,5S,6R)-3,4,5-trihydrox y-6-(hydroxymethyl)oxan-2-yl]oxyoxan-2-yl]oxy -4,5-dihydroxyoxan-2-yl]oxy-5-hydroxy-2,2,6a, 6b,9,9,12a-heptamethyl-1,3,4,5,6,6a,7,8,8a,10 ,11,12,13,14b-tetradecahydropicene-4a-carboxy lic acid
  • MW: 913.096 | Formula: C47H76O17
  • H donors: 10 H acceptors: 11 LogP: 2.66 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 4
  • SMILES: OC[C@H]1O[C@@H](O[C@H]2[C@@H](O)[C@H](O[C@H]3[C@@H](OC[C@@H]([C@@H]3O)O)O[C@H]3CC[C@]4([C@H](C3(C)C)CC[C@@]3([C@@H]4CC=C4[C@@]3(C)C[C@H]([C@@]3([C@H]4CC(C)(C)CC3)C(=O)O)O)C)C)O[C@H]([C@@H]2O)C)[C@@H]([C@H]([C@@H]1O)O)O
  • InChi: 1S/C47H76O17/c1-21-30(51)36(63-38-34(55)33(54)32(53)25(19-48)61-38)35(56)39(60-21)64-37-31(52)24(49)20-59-40(37)62-29-12-13-44(6)26(43(29,4)5)11-14-45(7)27(44)10-9-22-23-17-42(2,3)15-16-47(23,41(57)58)28(50)18-46(22,45)8/h9,21,23-40,48-56H,10-20H2,1-8H3,(H,57,58)/t21-,23-,24-,25+,26-,27+,28+,29-,30-,31-,32+,33-,34+,35+,36+,37+,38-,39-,40-,44-,45+,46+,47+/m0/s1
  • InChiKey: YCIBWFKSAZNJMF-WYTBTIRESA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • (4aR,5R,6aR,6aS,6bR,8aR,10S,12aR,14bS)-10-[(2S,3R,4S,5S)-3-[(2S,3R,4R,5S,6S)-3,5-dihydroxy-6-methyl-4-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydropyran-2-yl]oxy-tetrahydropyran-2-yl]oxy-4,5-dihydroxy-tetrahydropyran-2-yl]oxy-5-hydroxy-2,2,6a,6b,9,9,12a-heptamethyl-1,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydropicene-4a-carboxylic acid
  • (4aR,5R,6aR,6aS,6bR,8aR,10S,12aR,14bS)-10-[[(2S,3R,4S,5S)-3-[[(2S,3R,4R,5S,6S)-3,5-dihydroxy-6-methyl-4-[[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)-2-tetrahydropyranyl]oxy]-2-tetrahydropyranyl]oxy]-4,5-dihydroxy-2-tetrahydropyranyl]oxy]-5-hydroxy-2,2,6a,6b,9,9,12a-heptamethyl-1,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydropicene-4a-carboxylic acid
  • (4aR,5R,6aR,6aS,6bR,8aR,10S,12aR,14bS)-10-[(2S,3R,4S,5S)-3-[(2S,3R,4R,5S,6S)-3,5-dihydroxy-6-methyl-4-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-methylol-tetrahydropyran-2-yl]oxy-tetrahydropyran-2-yl]oxy-4,5-dihydroxy-tetrahydropyran-2-yl]oxy-5-hydroxy-2,2,6a,6b,9,9,12a-heptamethyl-1,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydropicene-4a-carboxylic acid
  • (4aR,5R,6aR,6aS,6bR,8aR,10S,12aR,14bS)-10-[(2S,3R,4S,5S)-3-[(2S,3R,4R,5S,6S)-3,5-dihydroxy-6-methyl-4-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-oxan-2-yl]oxy-4,5-dihydroxy-oxan-2-yl]oxy-5-hydroxy-2,2,6a,6b,9,9,12a-heptamethyl-1,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydropicene-4a-carboxylic acid

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium vivax acyl-CoA synthetase, putative 0.002 0.0018 0.0714
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0074 0.0168 0.0167
Brugia malayi metabotropic glutamate receptor subtype 5a (mGluR5a), putative 0.0466 0.1239 0.4376
Mycobacterium tuberculosis Conserved protein 0.0074 0.0168 0.0759
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.0021 0.0021 0.007
Echinococcus granulosus jumonji domain containing protein 0.0042 0.008 0.008
Schistosoma mansoni hypothetical protein 0.0526 0.1404 0.1403
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0195 0.0498 0.0498
Brugia malayi PAN domain containing protein 0.0096 0.0226 0.0798
Echinococcus multilocularis beta LACTamase domain containing family member 0.0074 0.0168 0.0168
Trichomonas vaginalis CMGC family protein kinase 0.0119 0.0289 0.0685
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0119 0.0289 0.3813
Loa Loa (eye worm) PAN domain-containing protein 0.0096 0.0226 0.08
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0051 0.0103 0.0363
Onchocerca volvulus 0.0096 0.0226 0.0781
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0039 0.0136
Loa Loa (eye worm) glutamate receptor 0.0202 0.0517 0.1829
Echinococcus multilocularis peregrin 0.0034 0.0057 0.0057
Plasmodium vivax hypothetical protein, conserved 0.0074 0.0168 0.7481
Loa Loa (eye worm) CMGC/MAPK/P38 protein kinase 0.0289 0.0754 0.2664
Loa Loa (eye worm) PAN domain-containing protein 0.0096 0.0226 0.08
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0653 0.1752 0.6193
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0034 0.0056 0.0717
Entamoeba histolytica hypothetical protein 0.0038 0.0068 0.0157
Loa Loa (eye worm) RGC/RGC protein kinase 0.0048 0.0096 0.034
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0045 0.0087 0.1133
Brugia malayi Trypsin family protein 0.0021 0.0021 0.007
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.3411 0.93 0.93
Trypanosoma cruzi importin beta-1 subunit, putative 0.005 0.01 0.13
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0036 0.0125
Brugia malayi beta-lactamase family protein 0.0074 0.0168 0.0591
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.0168 0.0396
Trypanosoma brucei mitogen-activated protein kinase 3, putative 0.0289 0.0754 1
Echinococcus multilocularis pyruvate kinase 0.0038 0.0067 0.0067
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0018 0.0225
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0038 0.0068 0.0068
Echinococcus multilocularis dna polymerase eta 0.002 0.0018 0.0018
Schistosoma mansoni tyrosine kinase 0.0048 0.0096 0.0096
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0021 0.0021 0.002
Brugia malayi MAP kinase sur-1 0.0119 0.0289 0.1018
Giardia lamblia Kinase, CMGC MAPK 0.0119 0.0289 0.0685
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.0047 0.0112
Loa Loa (eye worm) hypothetical protein 0.0021 0.0021 0.0073
Trichomonas vaginalis Importin beta-1 subunit, putative 0.005 0.01 0.0233
Echinococcus granulosus mitogen activated protein kinase 14 0.0289 0.0754 0.0754
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.0085 0.0197 0.0465
Onchocerca volvulus 0.0074 0.0168 0.0558
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0045 0.0087 0.6583
Echinococcus granulosus pyruvate kinase 0.0019 0.0017 0.0017
Loa Loa (eye worm) trypsin family protein 0.0021 0.0021 0.0073
Loa Loa (eye worm) hypothetical protein 0.0364 0.0961 0.3395
Onchocerca volvulus 0.0108 0.0258 0.0902
Loa Loa (eye worm) receptor family ligand binding region containing protein 0.0132 0.0325 0.1147
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0364 0.0961 0.3393
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0048 0.011
Schistosoma mansoni jumonji/arid domain-containing protein 0.0037 0.0065 0.0064
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0036 0.0125
Leishmania major DNA polymerase eta, putative 0.002 0.0018 0.0218
Onchocerca volvulus 0.0984 0.2657 1
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0036 0.0125
Echinococcus granulosus mitogen activated protein kinase 11 0.0289 0.0754 0.0754
Brugia malayi jmjC domain containing protein 0.0037 0.0065 0.0226
Trichomonas vaginalis chromobox protein, putative 0.0077 0.0176 0.0415
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0018 0.0063
Trichomonas vaginalis CMGC family protein kinase 0.0119 0.0289 0.0685
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0095 0.0224 0.0223
Echinococcus granulosus lamin dm0 0.0027 0.0039 0.0039
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0018 0.0218
Mycobacterium tuberculosis Probable lipase LipD 0.0074 0.0168 0.0759
Loa Loa (eye worm) hypothetical protein 0.0173 0.0438 0.155
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0195 0.0498 0.0498
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.002 0.0018 0.0018
Echinococcus granulosus c-Jun N-terminal kinases 0.1047 0.2829 0.2829
Echinococcus granulosus peregrin 0.0034 0.0057 0.0057
Trichomonas vaginalis importin beta-1, putative 0.005 0.01 0.0233
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0108 0.0258 0.0258
Loa Loa (eye worm) PAN domain-containing protein 0.0096 0.0226 0.08
Mycobacterium tuberculosis Conserved protein 0.0074 0.0168 0.0759
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0026 0.0036 0.0091
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1544 0.4189 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0021 0.0073
Brugia malayi hypothetical protein 0.0038 0.0068 0.0238
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.0036 0.0453
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0223 0.0575 0.0575
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0058 0.0134
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0136 0.0335 0.4435
Schistosoma mansoni pyruvate kinase 0.0019 0.0017 0.0016
Brugia malayi PAN domain containing protein 0.0096 0.0226 0.0798
Echinococcus granulosus PHD finger protein rhinoceros 0.003 0.0047 0.0047
Loa Loa (eye worm) pip kinase 2 0.0173 0.0438 0.155
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0058 0.0123 0.0123
Echinococcus granulosus GPCR family 2 0.0065 0.0143 0.0143
Loa Loa (eye worm) hypothetical protein 0.025 0.0647 0.2288
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0039 0.0136
Onchocerca volvulus Metabotropic glutamate receptor homolog 0.0083 0.0192 0.0651
Echinococcus multilocularis snurportin 1 0.0653 0.1752 0.1752
Schistosoma mansoni hypothetical protein 0.0653 0.1752 0.1751
Echinococcus granulosus histone lysine methyltransferase setb 0.0095 0.0224 0.0224
Trypanosoma brucei pyruvate kinase 1, putative 0.0038 0.0067 0.087
Onchocerca volvulus 0.0096 0.0226 0.0781
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0754 0.2028 1
Brugia malayi Trypsin family protein 0.0021 0.0021 0.007
Leishmania major pyruvate kinase 0.0038 0.0067 0.0864
Loa Loa (eye worm) hypothetical protein 0.0048 0.0096 0.034
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0066 0.0154
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0119 0.0289 0.3813
Toxoplasma gondii microneme protein, putative 0.0096 0.0226 0.0555
Trichomonas vaginalis pyruvate kinase, putative 0.0038 0.0067 0.0155
Plasmodium vivax hypothetical protein, conserved 0.003 0.0047 0.2038
Brugia malayi PAN domain containing protein 0.0096 0.0226 0.0798
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0095 0.0224 0.0548
Mycobacterium leprae conserved hypothetical protein 0.0074 0.0168 0.0661
Schistosoma mansoni phosphatidylinositol-4-phosphate-5-kinaseputativ e 0.0014 0.0002 0.0001
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0661 0.1774 0.627
Brugia malayi hypothetical protein 0.0034 0.0058 0.0202
Brugia malayi metabotropic glutamate receptor type 2 0.0251 0.065 0.2294
Brugia malayi Trypsin-like protease protein 5 0.0021 0.0021 0.007
Trichomonas vaginalis chromobox protein, putative 0.0047 0.0092 0.0214
Loa Loa (eye worm) hypothetical protein 0.0074 0.0168 0.0593
Giardia lamblia Pyruvate kinase 0.0019 0.0017 0.0035
Loa Loa (eye worm) hypothetical protein 0.002 0.0018 0.0063
Plasmodium vivax pyruvate kinase 2, putative 0.0019 0.0017 0.0667
Echinococcus granulosus glutamate receptor 2 0.0048 0.0096 0.0096
Brugia malayi hypothetical protein 0.0089 0.0208 0.0733
Mycobacterium ulcerans esterase/lipase LipP 0.0074 0.0168 0.0746
Loa Loa (eye worm) hypothetical protein 0.0053 0.0109 0.0387
Plasmodium vivax SET domain protein, putative 0.0095 0.0224 1
Mycobacterium ulcerans lipase LipD 0.0074 0.0168 0.0746
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0066 0.0855
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0074 0.0168 0.0759
Loa Loa (eye worm) hypothetical protein 0.0021 0.0021 0.0073
Schistosoma mansoni cercarial elastase (S01 family) 0.0021 0.0021 0.002
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0058 0.0123 0.0122
Onchocerca volvulus Alhambra homolog 0.003 0.0047 0.0101
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.0036 0.0453
Echinococcus granulosus glycoprotein Antigen 5 0.0021 0.0021 0.0021
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0051 0.0104 0.0104
Schistosoma mansoni hypothetical protein 0.0024 0.0029 0.0028
Loa Loa (eye worm) RGC/RGC protein kinase 0.0048 0.0096 0.034
Echinococcus granulosus phosphatidylinositol 5 phosphate 4 kinase type 2 0.0173 0.0438 0.0438
Brugia malayi Guanylyl cyclase protein 23 0.0048 0.0096 0.0338
Schistosoma mansoni aldehyde dehydrogenase 0.0136 0.0335 0.0335
Toxoplasma gondii pyruvate kinase PyKII 0.0019 0.0017 0.0037
Plasmodium vivax pyruvate kinase, putative 0.0038 0.0067 0.293
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0048 0.0096 0.0096
Onchocerca volvulus Pyruvate kinase homolog 0.0038 0.0067 0.0176
Brugia malayi intermediate filament protein 0.0027 0.0039 0.0134
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0036 0.0091
Chlamydia trachomatis pyruvate kinase 0.0038 0.0067 1
Trypanosoma brucei DNA polymerase eta, putative 0.002 0.0018 0.0225
Toxoplasma gondii hypothetical protein 0.0096 0.0226 0.0555
Echinococcus multilocularis PHD finger protein rhinoceros 0.003 0.0047 0.0047
Loa Loa (eye worm) FYVE finger-containing phosphoinositide kinase 0.0014 0.0002 0.0007
Echinococcus granulosus mitogen activated protein kinase 0.0119 0.0289 0.0289
Trypanosoma brucei phosphatidylinositol phosphate kinase alpha 0.0014 0.0002 0.0007
Loa Loa (eye worm) hypothetical protein 0.0021 0.0021 0.0073
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0051 0.0104 0.136
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0051 0.0104 0.0104
Schistosoma mansoni phosphatidylinositol-4-phosphate 5-kinase type II 0.0173 0.0438 0.0438
Loa Loa (eye worm) hypothetical protein 0.0132 0.0325 0.1147
Loa Loa (eye worm) hypothetical protein 0.0074 0.0168 0.0593
Entamoeba histolytica pyruvate kinase, putative 0.0026 0.0036 0.0081
Loa Loa (eye worm) metabotropic GABA-B receptor subtype 2 0.0132 0.0325 0.1147
Schistosoma mansoni hypothetical protein 0.0083 0.0192 0.0192
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0195 0.0498 0.0497
Loa Loa (eye worm) hypothetical protein 0.0984 0.2657 0.939
Loa Loa (eye worm) hypothetical protein 0.0021 0.0021 0.0073
Loa Loa (eye worm) hypothetical protein 0.002 0.0018 0.0063
Brugia malayi PAN domain containing protein 0.0096 0.0226 0.0798
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0066 0.0855
Echinococcus multilocularis jumonji domain containing protein 0.0042 0.008 0.008
Brugia malayi PAN domain containing protein 0.0096 0.0226 0.0798
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0058 0.0123 0.0521
Trypanosoma cruzi PAB1-binding protein , putative 0.0053 0.0109 0.1428
Echinococcus granulosus lamin 0.0027 0.0039 0.0039
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0045 0.0087 0.0306
Echinococcus multilocularis pyruvate kinase 0.0019 0.0017 0.0017
Onchocerca volvulus 0.0096 0.0226 0.0781
Toxoplasma gondii PAN/Apple domain-containing protein 0.0096 0.0226 0.0555
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0045 0.0087 0.1139
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.0021 0.0021 0.0021
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0021 0.0021 0.002
Echinococcus multilocularis mitogen activated protein kinase 11 0.0289 0.0754 0.0754
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0119 0.0289 0.3813
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1544 0.4189 1
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.002 0.0018 0.0018
Onchocerca volvulus 0.0173 0.0438 0.1585
Leishmania major importin beta-1 subunit, putative 0.005 0.01 0.13
Schistosoma mansoni hypothetical protein 0.003 0.0047 0.0046
Toxoplasma gondii isocitrate dehydrogenase 0.0051 0.0104 0.0253
Echinococcus multilocularis pyruvate kinase 0.0019 0.0017 0.0017
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0018 0.0225
Loa Loa (eye worm) pyruvate kinase 0.0038 0.0067 0.0237
Echinococcus granulosus Mastin 0.0021 0.0021 0.0021
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0018 0.0225
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0058 0.0123 0.0431
Schistosoma mansoni cercarial elastase (S01 family) 0.0021 0.0021 0.002
Trichomonas vaginalis ran, putative 0.0045 0.0087 0.0203
Loa Loa (eye worm) hypothetical protein 0.0089 0.0208 0.0736
Schistosoma mansoni hypothetical protein 0.0065 0.0143 0.0142
Schistosoma mansoni cercarial elastase (S01 family) 0.0021 0.0021 0.002
Loa Loa (eye worm) hypothetical protein 0.0151 0.0378 0.1336
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0051 0.0104 0.136
Loa Loa (eye worm) hypothetical protein 0.0026 0.0036 0.0128
Loa Loa (eye worm) hypothetical protein 0.0633 0.1696 0.5994
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0045 0.0087 0.0203
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0018 0.0225
Schistosoma mansoni hypothetical protein 0.0065 0.0143 0.0142
Schistosoma mansoni metabotropic glutamate receptor 0.0251 0.065 0.0649
Loa Loa (eye worm) RGC/RGC protein kinase 0.0048 0.0096 0.034
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.0047 0.0112
Loa Loa (eye worm) hypothetical protein 0.0048 0.0096 0.034
Echinococcus granulosus histone acetyltransferase KAT2B 0.0044 0.0084 0.0084
Schistosoma mansoni cercarial elastase (S01 family) 0.0021 0.0021 0.002
Trichomonas vaginalis CMGC family protein kinase 0.0119 0.0289 0.0685
Onchocerca volvulus 0.0048 0.0096 0.0287
Loa Loa (eye worm) jmjC domain-containing protein 0.0037 0.0065 0.0229
Brugia malayi Pyruvate kinase, muscle isozyme 0.0038 0.0067 0.0234
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.002 0.0018 0.0018
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0044 0.0084 0.0203
Mycobacterium tuberculosis Probable esterase LipL 0.0074 0.0168 0.0759
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0195 0.0498 0.176
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0026 0.0036 0.0091
Trypanosoma brucei ULK family serine/threonine-protein kinase, putative 0.0016 0.0007 0.0074
Echinococcus granulosus metabotropic glutamate receptor 2 0.0431 0.1142 0.1142
Trypanosoma cruzi hypothetical protein, conserved 0.0074 0.0168 0.2205
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0021 0.0021 0.002
Echinococcus granulosus receptor type guanylyl cyclase 0.0048 0.0096 0.0096
Entamoeba histolytica acyl-CoA synthetase, putative 0.0026 0.0036 0.0081
Echinococcus multilocularis nmda type glutamate receptor 0.0048 0.0096 0.0096
Brugia malayi hypothetical protein 0.0021 0.0021 0.007
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0021 0.0021 0.002
Brugia malayi Muscleblind-like protein 0.0151 0.0378 0.1334
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0018 0.0063
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.003 0.0047 0.0046
Loa Loa (eye worm) hypothetical protein 0.0052 0.0107 0.0377
Loa Loa (eye worm) hypothetical protein 0.0026 0.0036 0.0127
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0004 0.0014
Echinococcus multilocularis inositol monophosphatase 1 0.0037 0.0066 0.0066
Onchocerca volvulus 0.0096 0.0226 0.0781
Trypanosoma cruzi DNA polymerase eta, putative 0.002 0.0018 0.0218
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.0168 0.0396
Schistosoma mansoni DNA polymerase eta 0.002 0.0018 0.0018
Trypanosoma cruzi pyruvate kinase 2, putative 0.0038 0.0067 0.0864
Onchocerca volvulus 0.0753 0.2024 0.76
Echinococcus multilocularis geminin 0.0526 0.1404 0.1404
Loa Loa (eye worm) pip kinase 1 0.0014 0.0002 0.0007
Mycobacterium tuberculosis Probable hydrolase 0.0074 0.0168 0.0759
Entamoeba histolytica acetyltransferase, GNAT family 0.004 0.0074 0.0172
Echinococcus granulosus beta LACTamase domain containing family member 0.0074 0.0168 0.0168
Brugia malayi Pre-SET motif family protein 0.0095 0.0224 0.0788
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0119 0.0289 0.102
Brugia malayi latrophilin 2 splice variant baaae 0.0141 0.035 0.1233
Schistosoma mansoni inositol monophosphatase 0.0037 0.0066 0.0066
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.002 0.0018 0.0015
Mycobacterium ulcerans aldehyde dehydrogenase 0.0136 0.0335 0.158
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0018 0.0225
Loa Loa (eye worm) hypothetical protein 0.0061 0.0132 0.0465
Onchocerca volvulus 0.0096 0.0226 0.0781
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0048 0.0096 0.0096
Echinococcus multilocularis phosphatidylinositol phosphate 5 kinase type III 0.0014 0.0002 0.0002
Brugia malayi Pip kinase protein 2 0.0173 0.0438 0.1547
Loa Loa (eye worm) acetyltransferase 0.0149 0.0373 0.1317
Loa Loa (eye worm) glutamate receptor 0.0514 0.1371 0.4845
Loa Loa (eye worm) hypothetical protein 0.0089 0.0208 0.0736
Echinococcus granulosus expressed protein 0.0034 0.0058 0.0058
Schistosoma mansoni hypothetical protein 0.0065 0.0143 0.0142
Onchocerca volvulus 0.0096 0.0226 0.0781
Schistosoma mansoni phosphatidylinositol-4-phosphate 5-kinase type II 0.0014 0.0002 0.0001
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0119 0.0289 0.3813
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0051 0.0104 0.0104
Brugia malayi Receptor family ligand binding region containing protein 0.0132 0.0325 0.1145
Toxoplasma gondii PAN domain-containing protein 0.0096 0.0226 0.0555
Echinococcus granulosus phosphatidylinositol phosphate 5 kinase type III 0.0014 0.0002 0.0002
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0066 0.0154
Plasmodium falciparum ataxin-2 like protein, putative 0.0053 0.0109 0.8297
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0026 0.0036 0.0091
Schistosoma mansoni hypothetical protein 0.0021 0.0021 0.002
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1544 0.4189 1
Schistosoma mansoni ran 0.0045 0.0087 0.0087
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0026 0.0036 0.0105
Schistosoma mansoni survival motor neuron protein 0.0051 0.0103 0.0103
Brugia malayi RNA, U transporter 1 0.0174 0.044 0.1554
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0083 0.0193
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0021 0.0021 0.002
Echinococcus granulosus chromobox protein 1 0.0077 0.0176 0.0176
Brugia malayi Stress-activated protein kinase jnk-1 0.1047 0.2829 1
Loa Loa (eye worm) hypothetical protein 0.0095 0.0224 0.079
Entamoeba histolytica hypothetical protein 0.0048 0.0096 0.0225
Loa Loa (eye worm) metabotropic glutamate receptor 8 0.0048 0.0096 0.034
Schistosoma mansoni phosphatidylinositol-4-phosphate 5-kinase type II 0.0173 0.0438 0.0438
Entamoeba histolytica acyl-CoA synthetase, putative 0.0026 0.0036 0.0081
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0119 0.0289 0.3813
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0034 0.0058 0.0206
Toxoplasma gondii 1,3(4)-beta-glucanase 0.0096 0.0226 0.0555
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1544 0.4189 1
Brugia malayi hypothetical protein 0.0053 0.0109 0.0384
Trypanosoma cruzi PAB1-binding protein , putative 0.0053 0.0109 0.1428
Echinococcus multilocularis Phosphatidylinositol 4 phosphate 5 kinase type 1 0.0014 0.0002 0.0002
Brugia malayi hypothetical protein 0.0048 0.0096 0.0338
Schistosoma mansoni jumonji/arid domain-containing protein 0.0037 0.0065 0.0064
Onchocerca volvulus 0.0096 0.0226 0.0781
Echinococcus multilocularis c Jun NH2 terminal kinase 0.1047 0.2829 0.2829
Echinococcus multilocularis chromobox protein 1 0.0077 0.0176 0.0176
Schistosoma mansoni lamin 0.0027 0.0039 0.0038
Echinococcus granulosus transmembrane protease serine 3 0.0021 0.0021 0.0021
Trichomonas vaginalis DNA polymerase eta, putative 0.002 0.0018 0.0039
Loa Loa (eye worm) hypothetical protein 0.0043 0.0083 0.0293
Entamoeba histolytica hypothetical protein 0.005 0.01 0.0233
Entamoeba histolytica hypothetical protein 0.0038 0.0068 0.0157
Onchocerca volvulus 0.0096 0.0226 0.0781
Toxoplasma gondii PAN domain-containing protein 0.0096 0.0226 0.0555
Trypanosoma brucei hypothetical protein, conserved 0.0074 0.0168 0.221
Schistosoma mansoni cercarial elastase (S01 family) 0.0021 0.0021 0.002
Echinococcus multilocularis microtubule associated protein 2 0.3667 1 1
Schistosoma mansoni hypothetical protein 0.0065 0.0143 0.0142
Schistosoma mansoni tyrosine kinase 0.0048 0.0096 0.0096
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0036 0.0091
Brugia malayi Bromodomain containing protein 0.0034 0.0057 0.02
Brugia malayi P38 map kinase family protein 2 0.0289 0.0754 0.2662
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.01 0.0237 0.0237
Toxoplasma gondii microneme protein MIC17B 0.0096 0.0226 0.0555
Schistosoma mansoni cercarial elastase (S01 family) 0.0021 0.0021 0.002
Loa Loa (eye worm) hypothetical protein 0.0096 0.0226 0.08
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0051 0.0104 0.0104
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0043 0.0083 0.0236
Trichomonas vaginalis esterase, putative 0.0074 0.0168 0.0396
Plasmodium vivax importin-beta 2, putative 0.0061 0.0132 0.5842
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0038 0.0067 0.0259
Trypanosoma brucei importin beta-1 subunit, putative 0.0061 0.0132 0.1727
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.0168 0.0396
Echinococcus multilocularis importin subunit beta 1 0.0061 0.0132 0.0132
Echinococcus multilocularis pyruvate kinase 0.0019 0.0017 0.0017
Loa Loa (eye worm) isocitrate dehydrogenase 0.0051 0.0104 0.0369
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0045 0.0087 0.1133
Brugia malayi Trypsin family protein 0.0021 0.0021 0.007
Loa Loa (eye worm) hypothetical protein 0.0027 0.0039 0.0136
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0051 0.0104 0.1366
Mycobacterium leprae Probable pyruvate kinase PykA 0.0038 0.0067 0.0155
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0065 0.0143 0.0143
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0018 0.0225
Loa Loa (eye worm) hypothetical protein 0.0096 0.0226 0.08
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0038 0.0068 0.0068
Loa Loa (eye worm) hypothetical protein 0.0085 0.0197 0.0696
Loa Loa (eye worm) hypothetical protein 0.0141 0.035 0.1236
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.002 0.0018 0.0018
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0044 0.0084 0.0196
Trypanosoma cruzi extracellular receptor, putative 0.0048 0.0096 0.1253
Echinococcus multilocularis muscleblind protein 0.0151 0.0378 0.0378
Leishmania major hypothetical protein, conserved 0.0074 0.0168 0.2205
Mycobacterium ulcerans hypothetical protein 0.0026 0.0036 0.0091
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0024 0.0029 0.0029
Brugia malayi Pip kinase protein 1 0.0014 0.0002 0.0005
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0195 0.0498 0.0497
Brugia malayi PAN domain containing protein 0.0096 0.0226 0.0798
Loa Loa (eye worm) hypothetical protein 0.0096 0.0226 0.08
Echinococcus multilocularis pyruvate kinase 0.0038 0.0067 0.0067
Toxoplasma gondii hypothetical protein 0.0096 0.0226 0.0555
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0289 0.0754 1
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0074 0.0168 0.0591
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0136 0.0335 0.0335
Brugia malayi hypothetical protein 0.0984 0.2657 0.939
Entamoeba histolytica Ran family GTPase 0.0045 0.0087 0.0203
Toxoplasma gondii peptidylprolyl isomerase 0.0034 0.0056 0.0133
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0119 0.0289 0.3813
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0021 0.0021 0.002
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0018 0.0003
Leishmania major pyruvate kinase 0.0038 0.0067 0.0864
Echinococcus granulosus glutamate receptor 2 0.0048 0.0096 0.0096
Plasmodium falciparum acyl-CoA synthetase 0.002 0.0018 0.1222
Echinococcus multilocularis lysine specific demethylase 5A 0.0037 0.0065 0.0065
Schistosoma mansoni serine/threonine protein kinase 0.0119 0.0289 0.0288
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0065 0.0143 0.0501
Echinococcus multilocularis mitogen activated protein kinase 14 0.0289 0.0754 0.0754
Loa Loa (eye worm) hypothetical protein 0.003 0.0047 0.0167
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1544 0.4189 1
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0083 0.0193
Schistosoma mansoni intermediate filament proteins 0.0027 0.0039 0.0038
Toxoplasma gondii PAN domain-containing protein 0.0096 0.0226 0.0555
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0051 0.0104 0.0444
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0037 0.0066 0.0154
Schistosoma mansoni cercarial elastase (S01 family) 0.0021 0.0021 0.002
Schistosoma mansoni pyruvate kinase 0.0038 0.0067 0.0066
Toxoplasma gondii PAN domain-containing protein 0.0096 0.0226 0.0555
Loa Loa (eye worm) hypothetical protein 0.0074 0.0168 0.0593
Echinococcus multilocularis lamin dm0 0.0027 0.0039 0.0039
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.0085 0.0197 0.0465
Plasmodium falciparum importin beta, putative 0.0061 0.0132 1
Echinococcus multilocularis glycoprotein Antigen 5 0.0021 0.0021 0.0021
Giardia lamblia DINP protein human, muc B family 0.002 0.0018 0.0039
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0095 0.0224 0.0224
Echinococcus granulosus nmda type glutamate receptor 0.0048 0.0096 0.0096
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.01 0.0237 0.0237
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0037 0.0066 0.0159
Schistosoma mansoni ran 0.0045 0.0087 0.0087
Mycobacterium ulcerans hypothetical protein 0.0074 0.0168 0.0746
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.0021 0.0021 0.0021
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0045 0.0087 0.3845
Echinococcus granulosus pyruvate kinase 0.0019 0.0017 0.0017
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.1544 0.4189 1
Loa Loa (eye worm) pyruvate kinase 0.0038 0.0067 0.0237
Echinococcus multilocularis mitogen activated protein kinase 3 0.0119 0.0289 0.0289
Onchocerca volvulus Atrial natriuretic peptide receptor 3 homolog 0.0048 0.0096 0.0287
Trichomonas vaginalis bromodomain-containing protein, putative 0.0044 0.0084 0.0196
Brugia malayi PHD-finger family protein 0.003 0.0047 0.0164
Toxoplasma gondii PAN domain-containing protein 0.149 0.4041 1
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.0021 0.0021 0.0021
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0037 0.0066 0.5
Echinococcus multilocularis metabotropic glutamate receptor 5 0.0633 0.1696 0.1696
Loa Loa (eye worm) hypothetical protein 0.002 0.0018 0.0063
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0018 0.0225
Trypanosoma brucei unspecified product 0.002 0.0018 0.0225
Loa Loa (eye worm) PHD-finger family protein 0.003 0.0047 0.0167
Loa Loa (eye worm) hypothetical protein 0.0074 0.0168 0.0593
Schistosoma mansoni eyes absent homolog 0.0089 0.0208 0.0207
Trypanosoma brucei importin beta-1 subunit, putative 0.0061 0.0132 0.1727
Schistosoma mansoni microtubule-associated protein tau 0.3667 1 1
Giardia lamblia Histone acetyltransferase GCN5 0.004 0.0074 0.0172
Brugia malayi Importin beta-1 subunit 0.0061 0.0132 0.0462
Echinococcus multilocularis atrial natriuretic peptide receptor 0.0048 0.0096 0.0096
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0018 0.0225
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.002 0.0018 0.0218
Schistosoma mansoni aldehyde dehydrogenase 0.0136 0.0335 0.0335
Giardia lamblia PHD finger protein 15 0.003 0.0047 0.0108
Toxoplasma gondii ABC1 family protein 0.0074 0.0168 0.041
Leishmania major GTP-binding protein, putative 0.0045 0.0087 0.1133
Brugia malayi beta-lactamase family protein 0.0074 0.0168 0.0591
Trichomonas vaginalis penicillin-binding protein, putative 0.0074 0.0168 0.0396
Loa Loa (eye worm) hypothetical protein 0.0021 0.0021 0.0073
Loa Loa (eye worm) hypothetical protein 0.0096 0.0226 0.08
Loa Loa (eye worm) hypothetical protein 0.002 0.0018 0.0063
Mycobacterium ulcerans aldehyde dehydrogenase 0.0136 0.0335 0.158
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0039 0.0134
Loa Loa (eye worm) hypothetical protein 0.0026 0.0036 0.0128
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0026 0.0036 0.0105
Schistosoma mansoni serine/threonine protein kinase 0.1047 0.2829 0.2829
Loa Loa (eye worm) PAN domain-containing protein 0.0096 0.0226 0.08
Brugia malayi PAN domain containing protein 0.0096 0.0226 0.0798
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0051 0.0104 0.0104
Mycobacterium ulcerans beta-lactamase 0.0074 0.0168 0.0746
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0058 0.0123 0.1603
Trichomonas vaginalis rotamase, putative 0.0034 0.0058 0.0134
Plasmodium falciparum histone acetyltransferase GCN5 0.004 0.0074 0.5571
Echinococcus multilocularis GPCR, family 3, C terminal 0.0083 0.0192 0.0192
Brugia malayi Receptor family ligand binding region containing protein 0.0048 0.0096 0.0338
Onchocerca volvulus 0.0048 0.0096 0.0287
Echinococcus multilocularis chromobox protein 1 0.0077 0.0176 0.0176
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0051 0.0104 0.1366
Plasmodium falciparum phd finger protein, putative 0.003 0.0047 0.3489
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0026 0.0036 0.0091
Loa Loa (eye worm) PAN domain-containing protein 0.0096 0.0226 0.08
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.002 0.0018 0.0065
Brugia malayi PAN domain containing protein 0.0096 0.0226 0.0798
Mycobacterium ulcerans pyruvate kinase 0.0038 0.0067 0.0244
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0018 0.0225
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.0048 0.0096 0.0096
Entamoeba histolytica deoxycytidyl transferase, putative 0.002 0.0018 0.0039
Echinococcus granulosus atrial natriuretic peptide receptor 0.0048 0.0096 0.0096
Echinococcus multilocularis phosphatidylinositol 5 phosphate 4 kinase type 2 0.0173 0.0438 0.0438
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0021 0.0021 0.002
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0034 0.0058 0.0203
Trichomonas vaginalis inositol monophosphatase, putative 0.0037 0.0066 0.0154
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0095 0.0224 0.0224
Echinococcus granulosus pyruvate kinase 0.0038 0.0067 0.0067
Onchocerca volvulus 0.0027 0.0039 0.0068
Loa Loa (eye worm) hypothetical protein 0.0048 0.0096 0.034
Echinococcus granulosus intermediate filament protein 0.0027 0.0039 0.0039
Schistosoma mansoni inositol monophosphatase 0.0037 0.0066 0.0066
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0051 0.0104 0.7901
Toxoplasma gondii microneme protein MIC17C 0.0096 0.0226 0.0555
Echinococcus granulosus importin subunit beta 1 0.0061 0.0132 0.0132
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0033 0.0056 0.0202
Brugia malayi Pre-SET motif family protein 0.0661 0.1774 0.6269
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0033 0.0056 0.0098
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0018 0.0003
Treponema pallidum fructose-bisphosphate aldolase 0.1544 0.4189 0.5
Schistosoma mansoni protein kinase 0.0048 0.0096 0.0096
Echinococcus granulosus Phosphatidylinositol 4 phosphate 5 kinase type 1 0.0014 0.0002 0.0002
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0074 0.0168 0.0167
Leishmania major DNA polymerase kappa, putative 0.002 0.0018 0.0218
Brugia malayi cytoplasmic intermediate filament protein 0.0015 0.0004 0.0011
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0136 0.0335 0.1592
Toxoplasma gondii pyruvate kinase PyK1 0.0038 0.0067 0.0161
Schistosoma mansoni hypothetical protein 0.0141 0.035 0.0349
Trypanosoma brucei phosphatidylinositol (3,5) kinase, putative 0.0014 0.0002 0.0007
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0036 0.0091
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.0021 0.0021 0.0021
Echinococcus granulosus inositol monophosphatase 1 0.0037 0.0066 0.0066
Loa Loa (eye worm) hypothetical protein 0.0096 0.0226 0.08
Schistosoma mansoni terminal deoxycytidyl transferase 0.002 0.0018 0.0018
Echinococcus multilocularis survival motor neuron protein 1 0.025 0.0647 0.0647
Schistosoma mansoni cercarial elastase (S01 family) 0.0021 0.0021 0.002
Echinococcus granulosus GTP binding nuclear protein Ran 0.0045 0.0087 0.0087
Echinococcus multilocularis glutamate receptor 2 0.0048 0.0096 0.0096
Loa Loa (eye worm) heterochromatin protein 1 0.0077 0.0176 0.0622
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0021 0.0021 0.002
Trypanosoma cruzi pyruvate kinase 2, putative 0.0038 0.0067 0.0864
Toxoplasma gondii isocitrate dehydrogenase 0.0051 0.0104 0.0253
Trichomonas vaginalis chromobox protein, putative 0.0077 0.0176 0.0415
Loa Loa (eye worm) latrophilin receptor protein 2 0.0065 0.0143 0.0504
Echinococcus granulosus enteropeptidase 0.0021 0.0021 0.0021
Trypanosoma brucei pyruvate kinase 1 0.0038 0.0067 0.087
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0074 0.0168 0.0759
Echinococcus multilocularis enteropeptidase 0.0021 0.0021 0.0021
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0074 0.0168 0.0593
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0149 0.0373 0.0372
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0024 0.0029 0.0029
Trichomonas vaginalis set domain proteins, putative 0.0753 0.2024 0.483
Schistosoma mansoni transcription factor LCR-F1 0.0038 0.0068 0.0067
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.0048 0.0096 0.0096
Brugia malayi chromobox protein homolog 3 0.0043 0.0083 0.029
Schistosoma mansoni phosphatidylinositol-4-phosphate 5-kinase type II 0.0014 0.0002 0.0001
Loa Loa (eye worm) hypothetical protein 0.0083 0.0192 0.068
Echinococcus granulosus geminin 0.0526 0.1404 0.1404
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0058 0.0123 0.0123
Onchocerca volvulus 0.0096 0.0226 0.0781
Brugia malayi Metabotropic glutamate receptor precursor. 0.0514 0.1371 0.4844
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0195 0.0498 0.0497
Leishmania major mitogen-activated protein kinase 3, putative,map kinase 3, putative 0.0289 0.0754 1
Loa Loa (eye worm) pyruvate kinase-PB 0.0026 0.0036 0.0127
Trypanosoma brucei PAB1-binding protein , putative 0.0053 0.0109 0.1434
Toxoplasma gondii microneme protein MIC17A 0.0096 0.0226 0.0555
Mycobacterium tuberculosis Conserved hypothetical protein 0.002 0.0018 0.0018
Leishmania major hypothetical protein, conserved 0.0053 0.0109 0.1428
Brugia malayi FYVE finger-containing phosphoinositide kinase, putative 0.0014 0.0002 0.0005
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0136 0.0335 0.0335
Onchocerca volvulus 0.0096 0.0226 0.0781
Echinococcus multilocularis expressed protein 0.0034 0.0058 0.0058
Schistosoma mansoni chromobox protein 0.0077 0.0176 0.0175
Trypanosoma brucei phosphatidylinositol-4-phosphate 5-kinase, putative 0.0014 0.0002 0.0007
Echinococcus granulosus tyrosine kinase 0.0048 0.0096 0.0096
Brugia malayi jmjC domain containing protein 0.01 0.0237 0.0834
Schistosoma mansoni cercarial elastase (S01 family) 0.0021 0.0021 0.002
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0034 0.0056 0.0723
Toxoplasma gondii PAN domain-containing protein 0.149 0.4041 1
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0048 0.011
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0066 0.0861
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0045 0.0087 0.0211
Echinococcus multilocularis mitogen activated protein kinase 0.0119 0.0289 0.0289
Schistosoma mansoni glutamate receptor NMDA 0.0048 0.0096 0.0096
Loa Loa (eye worm) CMGC/MAPK/JNK protein kinase 0.1047 0.2829 1
Toxoplasma gondii subtilisin SUB12 0.0096 0.0226 0.0555
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0095 0.0224 0.0223
Schistosoma mansoni hypothetical protein 0.0526 0.1404 0.1403
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0754 0.2028 1
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0149 0.0373 0.0373
Loa Loa (eye worm) hypothetical protein 0.002 0.0018 0.0065
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0223 0.0575 0.0575
Schistosoma mansoni phosphatidylinositol-4-phosphate 5-kinase type I 0.0014 0.0002 0.0001
Mycobacterium ulcerans aldehyde dehydrogenase 0.0136 0.0335 0.158
Echinococcus multilocularis Mastin 0.0021 0.0021 0.0021
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0034 0.0056 0.0717
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0074 0.0168 0.0759
Brugia malayi acetyltransferase, GNAT family protein 0.0149 0.0373 0.1315
Echinococcus granulosus survival motor neuron protein 1 0.025 0.0647 0.0647
Schistosoma mansoni chromobox protein 0.0077 0.0176 0.0175
Entamoeba histolytica hypothetical protein 0.0038 0.0068 0.0157
Onchocerca volvulus 0.0074 0.0168 0.0558
Toxoplasma gondii HEAT repeat-containing protein 0.0061 0.0132 0.032
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0048 0.0096 0.0096
Loa Loa (eye worm) hypothetical protein 0.0065 0.0143 0.0504
Brugia malayi Latrophilin receptor protein 2 0.0065 0.0143 0.0501
Brugia malayi Calcitonin receptor-like protein seb-1 0.0206 0.0528 0.1865
Trypanosoma brucei phosphatidylinositol-4-phosphate 5-kinase, putative 0.0014 0.0002 0.0007
Echinococcus multilocularis tyrosine kinase 0.0048 0.0096 0.0096
Echinococcus granulosus dna polymerase eta 0.002 0.0018 0.0018
Echinococcus multilocularis isocitrate dehydrogenase 0.0051 0.0104 0.0104
Echinococcus multilocularis mitogen activated protein kinase 14 0.0289 0.0754 0.0754
Echinococcus multilocularis pyruvate kinase 0.003 0.0045 0.0045
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0045 0.0087 0.0309
Loa Loa (eye worm) hypothetical protein 0.0074 0.0168 0.0593
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0018 0.0225
Brugia malayi hypothetical protein 0.025 0.0647 0.2286
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0037 0.0066 0.0241
Trichomonas vaginalis rotamase, putative 0.0034 0.0056 0.0129
Leishmania major extracellular receptor, putative 0.0048 0.0096 0.1253
Toxoplasma gondii LsmAD domain-containing protein 0.0053 0.0109 0.0266
Trichomonas vaginalis CMGC family protein kinase 0.0119 0.0289 0.0685
Brugia malayi metabotropic GABA-B receptor subtype 2 0.0083 0.0192 0.0677
Loa Loa (eye worm) hypothetical protein 0.0096 0.0226 0.08
Echinococcus granulosus dna polymerase kappa 0.002 0.0018 0.0018
Trypanosoma cruzi hypothetical protein, conserved 0.0074 0.0168 0.2205
Loa Loa (eye worm) hypothetical protein 0.0074 0.0168 0.0593
Echinococcus granulosus pyruvate kinase 0.0038 0.0067 0.0067
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.002 0.0018 0.0039
Brugia malayi beta-lactamase 0.0074 0.0168 0.0591
Schistosoma mansoni importin beta-1 0.0061 0.0132 0.0131
Loa Loa (eye worm) hypothetical protein 0.0048 0.0096 0.034
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0065 0.0143 0.0143
Brugia malayi PAN domain containing protein 0.0096 0.0226 0.0798
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0195 0.0498 0.0498
Echinococcus multilocularis mitogen activated protein kinase 11 0.0289 0.0754 0.0754
Entamoeba histolytica acyl-coA synthetase, putative 0.0026 0.0036 0.0081
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0195 0.0498 0.0498
Echinococcus multilocularis glutamate receptor 2 0.0048 0.0096 0.0096
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.0036 0.0453
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1544 0.4189 1
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0091 0.0214 0.0214
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0058 0.0123 0.0535
Trichomonas vaginalis penicillin-binding protein, putative 0.0074 0.0168 0.0396
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1544 0.4189 1
Schistosoma mansoni hypothetical protein 0.0051 0.0103 0.0103
Echinococcus granulosus histone acetyltransferase KAT2B 0.0145 0.0361 0.0361
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0195 0.0498 0.1758
Loa Loa (eye worm) hypothetical protein 0.002 0.0018 0.0063
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0044 0.0084 0.3707
Mycobacterium leprae Probable lipase LipE 0.0074 0.0168 0.0661
Plasmodium falciparum pyruvate kinase 2 0.0019 0.0017 0.1142
Trichomonas vaginalis pyruvate kinase, putative 0.0038 0.0067 0.0155
Onchocerca volvulus 0.0096 0.0226 0.0781
Brugia malayi metabotropic GABA-B receptor subtype 2 0.0048 0.0096 0.0338
Brugia malayi isocitrate dehydrogenase 0.0051 0.0104 0.0366
Loa Loa (eye worm) hypothetical protein 0.0151 0.0378 0.1336
Loa Loa (eye worm) hypothetical protein 0.0048 0.0096 0.034
Echinococcus granulosus metabotropic glutamate receptor 5 0.0633 0.1696 0.1696
Toxoplasma gondii aldehyde dehydrogenase 0.0136 0.0335 0.0825
Echinococcus granulosus chromobox protein 1 0.0077 0.0176 0.0176
Schistosoma mansoni lamin 0.0027 0.0039 0.0038
Echinococcus multilocularis musashi 0.0027 0.0039 0.0039
Brugia malayi Heterochromatin protein 1 0.0077 0.0176 0.0619
Toxoplasma gondii microneme protein MIC4 0.0096 0.0226 0.0555
Schistosoma mansoni metabotropic glutamate receptor 2 3 (mglur group 2) 0.0584 0.1564 0.1563
Trypanosoma brucei protein kinase, putative 0.0119 0.0289 0.3817
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0034 0.0056 0.0129
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1544 0.4189 1
Echinococcus granulosus lysine specific demethylase 5A 0.0037 0.0065 0.0065
Onchocerca volvulus Pyruvate kinase homolog 0.0038 0.0067 0.0176
Schistosoma mansoni pyruvate kinase 0.0038 0.0067 0.0066
Loa Loa (eye worm) hypothetical protein 0.0038 0.0067 0.0237
Mycobacterium tuberculosis Probable lipase LipE 0.0074 0.0168 0.0759
Brugia malayi Pyruvate kinase, M2 isozyme 0.0038 0.0067 0.0234
Onchocerca volvulus 0.0034 0.0057 0.0139
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0048 0.0096 0.0096
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0054 0.0112 0.0396
Loa Loa (eye worm) FYVE zinc finger family protein 0.0014 0.0002 0.0007
Onchocerca volvulus 0.0051 0.0103 0.0314
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0048 0.0096 0.0096
Echinococcus granulosus GPCR family 3 C terminal 0.0083 0.0192 0.0192
Onchocerca volvulus 0.0074 0.0168 0.0558
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0074 0.0168 0.0746
Onchocerca volvulus 0.0026 0.0036 0.0059
Brugia malayi PAN domain containing protein 0.0096 0.0226 0.0798
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0018 0.0218
Schistosoma mansoni cercarial elastase (S01 family) 0.0021 0.0021 0.002
Loa Loa (eye worm) hypothetical protein 0.0034 0.0057 0.0202
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0044 0.0084 0.0203
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0754 0.2028 1
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0018 0.0225
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0119 0.0289 0.3817
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0018 0.0218
Echinococcus multilocularis metabotropic glutamate receptor 2 0.0431 0.1142 0.1142
Onchocerca volvulus Pyruvate kinase homolog 0.0038 0.0067 0.0176
Echinococcus granulosus pyruvate kinase 0.0019 0.0017 0.0017
Loa Loa (eye worm) hypothetical protein 0.0026 0.0036 0.0128
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0051 0.0104 0.136
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0476 0.1266 0.6216
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0018 0.0225
Loa Loa (eye worm) hypothetical protein 0.0027 0.0037 0.0132
Echinococcus granulosus snurportin 1 0.0653 0.1752 0.1752
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0066 0.0855
Trichomonas vaginalis chromobox protein, putative 0.0047 0.0092 0.0214
Plasmodium falciparum ataxin-2 like protein, putative 0.0053 0.0109 0.8297
Loa Loa (eye worm) beta-lactamase 0.0074 0.0168 0.0593
Entamoeba histolytica hypothetical protein 0.0038 0.0068 0.0157
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0051 0.0104 0.4616
Echinococcus multilocularis muscleblind protein 1 0.0151 0.0378 0.0378
Schistosoma mansoni rotamase 0.0034 0.0058 0.0057
Mycobacterium ulcerans hypothetical protein 0.0021 0.0021 0.0013
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0206 0.0528 0.1867
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0018 0.0218
Plasmodium falciparum pyruvate kinase 0.0038 0.0067 0.5016
Schistosoma mansoni hypothetical protein 0.0038 0.0068 0.0067
Brugia malayi SET domain containing protein 0.0016 0.0008 0.0026
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0119 0.0289 0.0709
Mycobacterium tuberculosis Conserved protein 0.0074 0.0168 0.0759
Schistosoma mansoni metabotropic glutamate receptor 0.0431 0.1142 0.1142
Loa Loa (eye worm) inositol-1 0.0037 0.0066 0.0235
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0045 0.0087 0.0087
Echinococcus multilocularis dna polymerase kappa 0.002 0.0018 0.0018
Brugia malayi Trypsin family protein 0.0021 0.0021 0.007
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0051 0.0104 0.0104
Loa Loa (eye worm) hypothetical protein 0.0048 0.0096 0.034
Echinococcus granulosus mitogen activated protein kinase 3 0.0119 0.0289 0.0289
Echinococcus multilocularis transmembrane protease serine 3 0.0021 0.0021 0.0021
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0289 0.0754 1
Giardia lamblia Fructose-bisphosphate aldolase 0.1544 0.4189 1
Echinococcus granulosus muscleblind protein 0.0151 0.0378 0.0378
Loa Loa (eye worm) pyruvate kinase 0.0038 0.0067 0.0237
Onchocerca volvulus 0.0027 0.0039 0.0068
Brugia malayi Inositol-1 0.0037 0.0066 0.0232
Loa Loa (eye worm) hypothetical protein 0.0021 0.0021 0.0073
Onchocerca volvulus Poor gastrulation protein homolog 0.0083 0.0192 0.0651
Plasmodium vivax ataxin-2 like protein, putative 0.0053 0.0109 0.4847
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0095 0.0224 0.0223
Trichomonas vaginalis Importin beta-1 subunit, putative 0.005 0.01 0.0233
Schistosoma mansoni hypothetical protein 0.0021 0.0021 0.002
Schistosoma mansoni cercarial elastase (S01 family) 0.0021 0.0021 0.002
Schistosoma mansoni jumonji domain containing protein 0.0079 0.0181 0.018
Loa Loa (eye worm) hypothetical protein 0.0048 0.0096 0.034
Loa Loa (eye worm) jmjC domain-containing protein 0.0063 0.0136 0.048
Brugia malayi Isocitrate dehydrogenase 0.0051 0.0104 0.0366
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0048 0.0096 0.0096
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0047 0.0092 0.027
Echinococcus multilocularis lamin 0.0027 0.0039 0.0039
Echinococcus multilocularis GPCR, family 2 0.0065 0.0143 0.0143
Loa Loa (eye worm) hypothetical protein 0.0096 0.0226 0.08
Giardia lamblia Pyruvate kinase 0.0038 0.0067 0.0155
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.1544 0.4189 1
Echinococcus multilocularis receptor type guanylyl cyclase 0.0048 0.0096 0.0096
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0034 0.0056 0.0717
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0018 0.0225
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0058 0.0123 0.0521

Activities

Activity type Activity value Assay description Source Reference
IC50 (ADMET) = 0.19 uM Antiproliferative activity against mouse J774 cells assessed as reduction of cell growth after 72 hrs by MTT method ChEMBL. 10757708

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Mus musculus ChEMBL23 10757708

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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