Detailed information for compound 1003538

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 597.868 | Formula: C37H59NO5
  • H donors: 1 H acceptors: 3 LogP: 7.99 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 2
  • SMILES: CC(=O)OCC(NC(=O)[C@@]12CC[C@H]([C@@H]([C@H]2C2=CC[C@H]3[C@@]([C@@]2(CC1)C)(C)CC[C@@H]1[C@]3(C)CC[C@@H](C1(C)C)OC(=O)C)C)C)C
  • InChi: 1S/C37H59NO5/c1-22-13-18-37(32(41)38-23(2)21-42-25(4)39)20-19-35(9)27(31(37)24(22)3)11-12-29-34(8)16-15-30(43-26(5)40)33(6,7)28(34)14-17-36(29,35)10/h11,22-24,28-31H,12-21H2,1-10H3,(H,38,41)/t22-,23?,24+,28+,29-,30+,31+,34+,35-,36-,37+/m1/s1
  • InChiKey: APNMRFDQAGTIRO-LSBYEQMCSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0019 0.0013 0.0136
Plasmodium vivax thioredoxin reductase, putative 0.0054 0.0107 0.5048
Brugia malayi Cathepsin L-like precursor 0.0018 0.0012 0.0126
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.006 0.0123 0.0172
Schistosoma mansoni hypothetical protein 0.0119 0.0282 0.0277
Schistosoma mansoni hypothetical protein 0.0119 0.0282 0.0277
Leishmania major cathepsin L-like protease 0.0018 0.0012 0.0475
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.0045 0.0039
Onchocerca volvulus 0.0059 0.0123 0.1867
Echinococcus granulosus smad 0.0025 0.0031 0.0025
Loa Loa (eye worm) fibroinase 0.0018 0.0012 0.012
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0054 0.0108 0.0102
Brugia malayi Cathepsin L-like precursor 0.0018 0.0012 0.0126
Trichomonas vaginalis endoplasmin, putative 0.0023 0.0026 0.0333
Brugia malayi AMP-binding enzyme family protein 0.0028 0.0038 0.0392
Plasmodium falciparum thioredoxin reductase 0.0019 0.0013 0.039
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0036 0.2134
Leishmania major heat shock protein 83-1 0.0038 0.0066 0.4199
Brugia malayi MH2 domain containing protein 0.0025 0.0031 0.0315
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0012 0.0109
Loa Loa (eye worm) ctsf protein 0.0018 0.0012 0.012
Leishmania major heat shock protein 83-1 0.0038 0.0066 0.4199
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0019 0.0013 0.0547
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0091 0.0207 0.0302
Mycobacterium ulcerans transcriptional regulator 0.2411 0.6434 1
Brugia malayi hypothetical protein 0.0017 0.001 0.0106
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0012 0.0109
Schistosoma mansoni hypothetical protein 0.038 0.0983 0.0978
Echinococcus multilocularis peptidase Clp (S14 family) 0.006 0.0123 0.0118
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0012 0.0109
Plasmodium vivax SET domain protein, putative 0.0031 0.0048 0.21
Brugia malayi Thioredoxin reductase 0.0054 0.0107 0.1104
Brugia malayi MH1 domain containing protein 0.0014 0.0001 0.0006
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0054 0.0108 0.1107
Schistosoma mansoni lamin 0.0059 0.0123 0.0117
Entamoeba histolytica heat shock protein 90, putative 0.0038 0.0066 0.6591
Trypanosoma brucei heat shock protein, putative 0.0038 0.0066 0.4199
Echinococcus granulosus lipoxygenase domain containing protein 0.0066 0.0141 0.0136
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0031 0.0047 0.0014
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.003 0.0045 0.004
Leishmania major cathepsin L-like protease 0.0069 0.0149 1
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0017 0.0008 0.0199
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.0149 1
Brugia malayi heat shock protein 90 0.0038 0.0066 0.0678
Plasmodium falciparum thioredoxin reductase 0.0054 0.0107 0.5048
Schistosoma mansoni peptidase Clp (S14 family) 0.0091 0.0207 0.0202
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0091 0.0207 1
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0028 0.0038 0.0039
Entamoeba histolytica acyl-CoA synthetase, putative 0.0028 0.0038 0.357
Schistosoma mansoni hypothetical protein 0.038 0.0983 0.0978
Trypanosoma cruzi heat shock protein 90, putative 0.0038 0.0066 0.4199
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0091 0.0207 0.0202
Loa Loa (eye worm) hypothetical protein 0.0257 0.0653 0.6719
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0031 0.0047 0.2082
Loa Loa (eye worm) hypothetical protein 0.0091 0.0207 0.2128
Onchocerca volvulus 0.0028 0.0038 0.0522
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.005 0.0097 0.637
Trypanosoma cruzi heat shock protein 90, putative 0.003 0.0045 0.275
Schistosoma mansoni loxhd1 0.0066 0.0141 0.0136
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0135 0.0327 0.0322
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0091 0.0207 1
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0019 0.0013 0.0547
Loa Loa (eye worm) thioredoxin reductase 0.0054 0.0107 0.1099
Echinococcus granulosus lamin dm0 0.0059 0.0123 0.0117
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0091 0.0207 1
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.0048 0.21
Schistosoma mansoni rab6-interacting 0.0066 0.0141 0.0136
Leishmania major heat shock protein 83-1 0.0038 0.0066 0.4199
Schistosoma mansoni lipoxygenase 0.0256 0.0651 0.0646
Leishmania major heat shock protein 83-1 0.0038 0.0066 0.4199
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0036 0.0482
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0122 0.0292 0.0396
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0019 0.0013 0.039
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0012 0.0109
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.005 0.0097 1
Echinococcus granulosus cathepsin l cysteine peptidase 0.0018 0.0012 0.0007
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.003 0.0045 0.0011
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.006 0.0123 0.0133
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.007 0.1026
Loa Loa (eye worm) RNA binding protein 0.0074 0.0163 0.1674
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0021 0.0019 0.0942
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0012 0.0109
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.0078 0.1151
Echinococcus multilocularis musashi 0.0059 0.0123 0.0117
Toxoplasma gondii LsmAD domain-containing protein 0.0027 0.0036 0.1523
Leishmania major phosphatidylinositol 3-kinase, putative 0.0017 0.0008 0.0199
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0012 0.0109
Loa Loa (eye worm) hypothetical protein 0.0018 0.0012 0.012
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.005 0.0097 1
Loa Loa (eye worm) hypothetical protein 0.0376 0.0972 1
Schistosoma mansoni hypothetical protein 0.0257 0.0653 0.0648
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0091 0.0207 1
Toxoplasma gondii heat shock protein 90, putative 0.0038 0.0066 0.2996
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0063 0.0916
Schistosoma mansoni Smad4 0.0025 0.0031 0.0025
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0012 0.0109
Echinococcus granulosus intermediate filament protein 0.0059 0.0123 0.0117
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0012 0.0109
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0028 0.0038 0.0039
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0012 0.0109
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0119 0.0282 0.0277
Loa Loa (eye worm) hypothetical protein 0.0027 0.0036 0.0366
Trypanosoma cruzi cysteine peptidase, putative 0.0069 0.0149 1
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.0048 0.0042
Brugia malayi latrophilin 2 splice variant baaae 0.0257 0.0653 0.6717
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.0149 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0063 0.0916
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0019 0.0013 0.0008
Loa Loa (eye worm) hypothetical protein 0.0111 0.026 0.2675
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0054 0.0108 0.0102
Echinococcus multilocularis survival motor neuron protein 1 0.0257 0.0653 0.0648
Mycobacterium ulcerans acyl-CoA synthetase 0.0028 0.0038 0.0039
Loa Loa (eye worm) hypothetical protein 0.0028 0.0038 0.0387
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0048 0.0042
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0018 0.0012 0.0007
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0019 0.0013 0.0547
Loa Loa (eye worm) doublecortin family protein 0.0066 0.0141 0.1445
Mycobacterium ulcerans AcrR family transcriptional regulator 0.2411 0.6434 1
Schistosoma mansoni cathepsin F (C01 family) 0.0018 0.0012 0.0007
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.007 0.1026
Mycobacterium leprae Probable transcriptional regulatory repressor protein (TetR-family) EthR 0.2411 0.6434 1
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0019 0.0013 0.039
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0018 0.0012 0.012
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0019 0.0013 0.0008
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0219 0.0552 0.5676
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0021 0.0019 0.0009
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.0149 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0043 0.0604
Entamoeba histolytica acyl-coA synthetase, putative 0.0028 0.0038 0.357
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0119 0.0282 0.0277
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0019 0.0013 0.039
Echinococcus granulosus RUN 0.0066 0.0141 0.0136
Leishmania major cathepsin L-like protease 0.0069 0.0149 1
Echinococcus granulosus tar DNA binding protein 0.0074 0.0163 0.0158
Schistosoma mansoni tar DNA-binding protein 0.0074 0.0163 0.0158
Mycobacterium ulcerans heat shock protein 90 0.003 0.0045 0.0049
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0135 0.0327 0.0322
Onchocerca volvulus 0.025 0.0633 1
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0021 0.0019 0.0009
Brugia malayi Cathepsin L-like precursor 0.0018 0.0012 0.0126
Entamoeba histolytica hypothetical protein 0.0041 0.0073 0.7355
Toxoplasma gondii cathepsin CPL 0.0018 0.0012 0.0339
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0036 0.1523
Echinococcus granulosus mothers against decapentaplegic 5 0.0025 0.0031 0.0025
Echinococcus multilocularis Smad4 0.0025 0.0031 0.0025
Loa Loa (eye worm) hypothetical protein 0.0119 0.0282 0.2902
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0012 0.0109
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0008 0.0046
Loa Loa (eye worm) heat shock protein 75 0.0016 0.0005 0.0049
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0012 0.0109
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0012 0.0109
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0063 0.0916
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.007 0.1026
Echinococcus multilocularis cysteine protease 0.0018 0.0012 0.0007
Leishmania major cathepsin L-like protease 0.0018 0.0012 0.0475
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.005 0.0097 0.0092
Echinococcus granulosus TGF beta signal transducer SmadC 0.0025 0.0031 0.0025
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0036 0.1523
Leishmania major hypothetical protein, conserved 0.0027 0.0036 0.2134
Leishmania major heat shock protein 83-1 0.0038 0.0066 0.4199
Schistosoma mansoni endoplasmin 0.0038 0.0066 0.0061
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0028 0.0038 0.0039
Loa Loa (eye worm) hypothetical protein 0.0028 0.0037 0.0378
Onchocerca volvulus 0.0018 0.0012 0.0109
Trypanosoma brucei heat shock protein 90, putative 0.0038 0.0066 0.4199
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.0149 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0368 0.0951 0.978
Leishmania major heat shock protein 83-1 0.0038 0.0066 0.4199
Mycobacterium tuberculosis Probable dehydrogenase 0.0122 0.0292 0.0435
Brugia malayi Calcitonin receptor-like protein seb-1 0.0376 0.0972 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0012 0.0109
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0019 0.0013 0.0547
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.0149 1
Plasmodium vivax multidomain scavenger receptor, putative 0.0066 0.0141 0.6713
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0036 0.0482
Entamoeba histolytica acyl-CoA synthetase, putative 0.0028 0.0038 0.357
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.003 0.0045 0.1636
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0053 0.0761
Schistosoma mansoni heat shock protein 0.0038 0.0066 0.0061
Leishmania major heat shock protein 83-1 0.0038 0.0066 0.4199
Schistosoma mansoni microtubule-associated protein tau 0.3739 1 1
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0122 0.0292 0.0435
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0035 0.048
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0016 0.0005
Schistosoma mansoni cathepsin F (C01 family) 0.0018 0.0012 0.0007
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0091 0.0207 0.0265
Plasmodium vivax acyl-CoA synthetase, putative 0.0021 0.0019 0.0687
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0376 0.0972 1
Trypanosoma brucei heat shock protein, putative 0.0038 0.0066 0.4199
Toxoplasma gondii thioredoxin reductase 0.0054 0.0107 0.5048
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0028 0.0038 0.0039
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.007 0.1026
Leishmania major cysteine peptidase A (CPA) 0.0018 0.0012 0.0475
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0031 0.0048 0.0042
Loa Loa (eye worm) hypothetical protein 0.0021 0.0019 0.0192
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0019 0.0013 0.0547
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0376 0.0972 1
Echinococcus granulosus tumor protein p63 0.0756 0.1993 0.1988
Schistosoma mansoni tar DNA-binding protein 0.0074 0.0163 0.0158
Brugia malayi RNA binding protein 0.0074 0.0163 0.1679
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0091 0.0207 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0054 0.0108 0.1102
Schistosoma mansoni rab6-interacting 0.0066 0.0141 0.0136
Loa Loa (eye worm) glutathione reductase 0.0054 0.0107 0.1099
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0063 0.0916
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0012 0.0109
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0032 0.0049 0.0495
Entamoeba histolytica hypothetical protein 0.0041 0.0073 0.7355
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0136 0.0328 0.0492
Loa Loa (eye worm) heat shock protein 90 0.0038 0.0066 0.0672
Echinococcus multilocularis lipoxygenase domain containing protein 0.0066 0.0141 0.0136
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0036 0.2134
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.0149 1
Schistosoma mansoni lipoxygenase 0.0137 0.0332 0.0327
Giardia lamblia Grp94/Hsp90 0.003 0.0045 0.3783
Loa Loa (eye worm) endoplasmin 0.0038 0.0066 0.0672
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0054 0.0108 0.0102
Echinococcus multilocularis cathepsin L cysteine protease 0.0018 0.0012 0.0007
Leishmania major 4-coumarate:coa ligase-like protein 0.0028 0.0038 0.2274
Echinococcus multilocularis cathepsin L cysteine protease 0.0018 0.0012 0.0007
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0054 0.0108 0.0102
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.0149 1
Mycobacterium tuberculosis Probable oxidoreductase 0.0136 0.0328 0.0492
Brugia malayi Probable ClpP-like protease 0.0091 0.0207 0.2133
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0048 0.0042
Echinococcus multilocularis lamin dm0 0.0059 0.0123 0.0117
Trypanosoma cruzi heat shock protein 85, putative 0.0038 0.0066 0.4199
Schistosoma mansoni transcription factor LCR-F1 0.0041 0.0073 0.0068
Brugia malayi Latrophilin receptor protein 2 0.0119 0.0282 0.2906
Echinococcus multilocularis lipoxygenase domain containing protein 0.0066 0.0141 0.0136
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0019 0.0013 0.0547
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0041 0.0073 0.0068
Giardia lamblia Heat shock protein HSP 90-alpha 0.0038 0.0066 0.6271
Leishmania major heat shock protein 83-1 0.0038 0.0066 0.4199
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.005 0.0097 0.0092
Onchocerca volvulus 0.0018 0.0012 0.0109
Brugia malayi hypothetical protein 0.0041 0.0073 0.075
Echinococcus multilocularis tumor protein p63 0.0756 0.1993 0.1988
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0017 0.0008 0.0085
Leishmania major heat shock protein 83-1 0.0038 0.0066 0.4199
Trichomonas vaginalis heat shock protein, putative 0.003 0.0045 0.0631
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0256 0.0651 0.0646
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0012 0.0109
Echinococcus multilocularis microtubule associated protein 2 0.3739 1 1
Echinococcus multilocularis smad 0.0025 0.0031 0.0025
Trypanosoma cruzi trypanothione reductase, putative 0.0054 0.0107 0.7074
Plasmodium falciparum acyl-CoA synthetase 0.0021 0.0019 0.0687
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0091 0.0207 1
Onchocerca volvulus Cathepsin L homolog 0.0018 0.0012 0.0109
Loa Loa (eye worm) hypothetical protein 0.0028 0.0037 0.0378
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0122 0.0292 0.0435
Brugia malayi MH1 domain containing protein 0.0014 0.0001 0.0006
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.0149 1
Leishmania major heat shock protein 83-1 0.0038 0.0066 0.4199
Leishmania major heat shock protein 83-1 0.0038 0.0066 0.4199
Onchocerca volvulus 0.0018 0.0012 0.0109
Loa Loa (eye worm) hypothetical protein 0.0257 0.0653 0.6715
Plasmodium vivax ataxin-2 like protein, putative 0.0027 0.0036 0.1523
Trypanosoma brucei heat shock protein, putative 0.0038 0.0066 0.4199
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0035 0.048
Loa Loa (eye worm) hypothetical protein 0.0059 0.0123 0.1256
Echinococcus multilocularis endoplasmin 0.003 0.0045 0.004
Brugia malayi MH2 domain containing protein 0.0025 0.0031 0.0315
Leishmania major 4-coumarate:coa ligase-like protein 0.0028 0.0038 0.2274
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0043 0.0604
Loa Loa (eye worm) Smad1 0.0025 0.0031 0.0309
Schistosoma mansoni smad1 5 8 and 0.0025 0.0031 0.0025
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0016 0.0005
Trypanosoma cruzi cysteine peptidase, putative 0.0069 0.0149 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.005 0.0097 0.1462
Schistosoma mansoni tar DNA-binding protein 0.0074 0.0163 0.0158
Loa Loa (eye worm) hypothetical protein 0.0029 0.004 0.0408
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0019 0.0013 0.0547
Brugia malayi hypothetical protein 0.0066 0.0141 0.145
Loa Loa (eye worm) hypothetical protein 0.0021 0.0019 0.0192
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0019 0.0013 0.0008
Onchocerca volvulus 0.0017 0.0009 0.0062
Echinococcus granulosus lamin 0.0059 0.0123 0.0117
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0063 0.0916
Plasmodium falciparum glutathione reductase 0.0054 0.0107 0.5048
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0256 0.0651 0.0646
Trichomonas vaginalis set domain proteins, putative 0.025 0.0633 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0016 0.0005
Plasmodium vivax glutathione reductase, putative 0.0054 0.0107 0.5048
Loa Loa (eye worm) hypothetical protein 0.0058 0.012 0.1226
Plasmodium vivax vivapain-2 0.0018 0.0012 0.0339
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.005 0.0097 0.637
Toxoplasma gondii heat shock protein HSP90 0.0038 0.0066 0.2996
Schistosoma mansoni hypothetical protein 0.0066 0.0141 0.0136
Brugia malayi MH1 domain containing protein 0.0025 0.0031 0.0315
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0043 0.0592
Echinococcus multilocularis thioredoxin glutathione reductase 0.0054 0.0107 0.0102
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0043 0.0592
Trichomonas vaginalis PIKK family atypical protein kinase 0.005 0.0097 0.1462
Loa Loa (eye worm) hypothetical protein 0.0021 0.0019 0.0192
Echinococcus granulosus heat shock protein 90 0.003 0.0045 0.004
Trypanosoma brucei heat shock protein 90, putative 0.0038 0.0066 0.4199
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0048 0.0042
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0012 0.0109
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0036 0.0482
Onchocerca volvulus 0.0031 0.0048 0.0675
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0021 0.0019 0.0309
Leishmania major heat shock protein 83-1 0.0038 0.0066 0.4199
Schistosoma mansoni survival motor neuron protein 0.0052 0.0104 0.0099
Entamoeba histolytica cysteine proteinase, putative 0.0018 0.0012 0.0746
Echinococcus granulosus heat shock protein 0.0038 0.0066 0.0061
Brugia malayi intermediate filament protein 0.0059 0.0123 0.1261
Trichomonas vaginalis heat shock protein, putative 0.003 0.0045 0.0631
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.005 0.0097 0.637
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0019 0.0013 0.0547
Brugia malayi MH1 domain containing protein 0.0025 0.0031 0.0315
Onchocerca volvulus 0.0018 0.0012 0.0109
Brugia malayi AMP-binding enzyme family protein 0.0028 0.0038 0.0392
Trypanosoma brucei heat shock protein, putative 0.0038 0.0066 0.4199
Trichomonas vaginalis mercuric reductase, putative 0.0019 0.0013 0.0125
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0019 0.0013 0.0547
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0091 0.0207 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0119 0.0282 0.2902
Schistosoma mansoni thyroid hormone receptor 0.0146 0.0356 0.0351
Brugia malayi Smad1 0.0025 0.0031 0.0315
Echinococcus granulosus lipoxygenase domain containing protein 0.0066 0.0141 0.0136
Trypanosoma cruzi heat shock protein 85, putative 0.0038 0.0066 0.4199
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0018 0.0012 0.0339
Brugia malayi hypothetical protein 0.0066 0.0141 0.145
Trypanosoma brucei target of rapamycin kinase 3, putative 0.004 0.007 0.4478
Schistosoma mansoni polycystin 1-related 0.0066 0.0141 0.0136
Schistosoma mansoni thyroid hormone receptor 0.0146 0.0356 0.0351
Trypanosoma cruzi cruzipain precursor, putative 0.0069 0.0149 1
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0025 0.0031 0.0025
Schistosoma mansoni smad1 5 8 and 0.0025 0.0031 0.0025
Entamoeba histolytica heat shock protein 90, putative 0.0038 0.0066 0.6591
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.005 0.0715
Brugia malayi cytoplasmic intermediate filament protein 0.0032 0.0049 0.0501
Brugia malayi Pre-SET motif family protein 0.0031 0.0048 0.0492
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0091 0.0207 1
Onchocerca volvulus 0.0018 0.0012 0.0109
Echinococcus multilocularis heat shock protein 0.0038 0.0066 0.0061
Mycobacterium tuberculosis Probable reductase 0.0122 0.0292 0.0435
Brugia malayi Cathepsin L-like precursor 0.0018 0.0012 0.0126
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.003 0.0045 0.275
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.006 0.0123 0.0172
Loa Loa (eye worm) phosphatidylinositol 3 0.0017 0.0008 0.0079
Echinococcus multilocularis heat shock protein 90 0.003 0.0045 0.004
Schistosoma mansoni hypothetical protein 0.0135 0.0327 0.0322
Trichomonas vaginalis glutathione reductase, putative 0.0019 0.0013 0.0125
Echinococcus granulosus GPCR family 2 0.0119 0.0282 0.0277
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0059 0.0123 0.1256
Leishmania major heat shock protein 83-1 0.0038 0.0066 0.4199
Echinococcus granulosus Smad4 0.0025 0.0031 0.0025
Toxoplasma gondii NADPH-glutathione reductase 0.0019 0.0013 0.039
Trypanosoma cruzi Heat shock protein 83, putative 0.0038 0.0066 0.4199
Entamoeba histolytica hypothetical protein 0.0041 0.0073 0.7355
Onchocerca volvulus 0.0111 0.026 0.4062
Loa Loa (eye worm) hypothetical protein 0.0028 0.0038 0.0387
Trypanosoma brucei Heat shock protein 83, putative 0.0038 0.0066 0.4199
Brugia malayi Intermediate filament tail domain containing protein 0.0059 0.0123 0.1261
Plasmodium falciparum glutathione reductase 0.0019 0.0013 0.039
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0091 0.0207 0.0202
Leishmania major heat shock protein 83-1 0.0038 0.0066 0.4199
Leishmania major cathepsin L-like protease 0.0018 0.0012 0.0475
Onchocerca volvulus 0.0059 0.0123 0.1867
Echinococcus granulosus heat shock protein 90 0.0038 0.0066 0.0061
Leishmania major heat shock protein 83-1 0.0038 0.0066 0.4199
Brugia malayi hypothetical protein 0.0257 0.0653 0.6721
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0019 0.0013 0.0547
Schistosoma mansoni hypothetical protein 0.0119 0.0282 0.0277
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0019 0.0013 0.0547
Onchocerca volvulus 0.0066 0.0141 0.2159
Plasmodium vivax heat shock protein 86, putative 0.0038 0.0066 0.2996
Loa Loa (eye worm) transcription factor SMAD2 0.0368 0.0951 0.978
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.0149 1
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.005 0.0097 0.637
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0018 0.0012 0.0109
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0063 0.0133 0.8879
Leishmania major cathepsin L-like protease 0.0018 0.0012 0.0475
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.005 0.0097 0.0092
Plasmodium vivax endoplasmin, putative 0.0038 0.0066 0.2996
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0028 0.0038 0.0039
Echinococcus multilocularis lamin 0.0059 0.0123 0.0117
Brugia malayi glutathione reductase 0.0054 0.0107 0.1104
Toxoplasma gondii hypothetical protein 0.0031 0.0047 0.2082
Schistosoma mansoni smad 0.0025 0.0031 0.0025
Mycobacterium ulcerans acyl-CoA synthetase 0.0028 0.0038 0.0039
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0136 0.0328 0.0492
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0031 0.0047 0.176
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0008 0.0046
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0017 0.0008 0.0003
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0024 0.0027 0.1476
Echinococcus granulosus geminin 0.038 0.0983 0.0978
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0029 0.004 0.0035
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0028 0.0038 0.0039
Echinococcus multilocularis RUN 0.0066 0.0141 0.0136
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0019 0.0013 0.0547
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.004 0.007 0.4478
Brugia malayi hypothetical protein 0.0027 0.0036 0.0372
Brugia malayi AMP-binding enzyme family protein 0.0028 0.0038 0.0392
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0031 0.0048 0.0042
Trypanosoma cruzi cysteine peptidase, putative 0.0018 0.0012 0.0475
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0019 0.0013 0.0547
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0019 0.0013 0.0547
Schistosoma mansoni intermediate filament proteins 0.0059 0.0123 0.0117
Leishmania major heat shock protein 83-1 0.0038 0.0066 0.4199
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0012 0.0109
Onchocerca volvulus Cathepsin F homolog 0.0018 0.0012 0.0109
Loa Loa (eye worm) intermediate filament protein 0.0059 0.0123 0.1256
Trypanosoma cruzi heat shock protein 85, putative 0.003 0.0045 0.275
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0016 0.0005
Echinococcus multilocularis geminin 0.038 0.0983 0.0978
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0119 0.0282 0.0277
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.005 0.0097 0.1
Brugia malayi RNA recognition motif domain containing protein 0.0074 0.0163 0.1679
Loa Loa (eye worm) MH1 domain-containing protein 0.0025 0.0031 0.0309
Entamoeba histolytica cysteine proteinase, putative 0.0018 0.0012 0.0746
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.003 0.0045 0.005
Brugia malayi Cathepsin L-like precursor 0.0018 0.0012 0.0126
Plasmodium falciparum endoplasmin, putative 0.0023 0.0026 0.1034
Entamoeba histolytica cysteine protease, putative 0.0018 0.0012 0.0746
Onchocerca volvulus 0.0018 0.0012 0.0109
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0012 0.0109
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0012 0.0109
Brugia malayi Hsp90 protein 0.0016 0.0005 0.0055
Plasmodium falciparum cysteine proteinase falcipain 3 0.0018 0.0012 0.0339
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0017 0.0008 0.0199
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0074 0.0163 0.1674
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0019 0.0013 0.0547
Brugia malayi TAR-binding protein 0.0074 0.0163 0.1679
Trypanosoma cruzi heat shock protein 90, putative 0.0023 0.0024 0.1284
Giardia lamblia Heat shock protein HSP 90-alpha 0.003 0.0045 0.3783
Mycobacterium ulcerans acyl-CoA synthetase 0.0028 0.0038 0.0039
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.007 0.1026
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0031 0.0047 0.2082
Trypanosoma cruzi target of rapamycin kinase 3 0.004 0.007 0.4478
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0122 0.0292 0.0435
Trypanosoma cruzi heat shock protein 85, putative 0.0038 0.0066 0.4199
Echinococcus multilocularis thyroid hormone receptor alpha 0.0146 0.0356 0.0351
Schistosoma mansoni endoplasmin 0.0038 0.0066 0.0061
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0119 0.0282 0.2906
Brugia malayi Pre-SET motif family protein 0.0219 0.0552 0.5678
Mycobacterium ulcerans TetR family transcriptional regulator 0.2411 0.6434 1
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.005 0.0097 0.637
Schistosoma mansoni heat shock protein 0.0038 0.0066 0.0061
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0052 0.0104 0.1071
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0119 0.0282 0.0277
Schistosoma mansoni hypothetical protein 0.0119 0.0282 0.0277
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0036 0.0482
Leishmania major cathepsin L-like protease 0.0069 0.0149 1
Trypanosoma cruzi cysteine peptidase, putative 0.0069 0.0149 1
Plasmodium falciparum LCCL domain-containing protein 0.0066 0.0141 0.6713
Plasmodium vivax vivapain-2 0.0018 0.0012 0.0339
Loa Loa (eye worm) hypothetical protein 0.0031 0.0048 0.0486
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0012 0.0109
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0019 0.0013 0.0547
Onchocerca volvulus 0.0066 0.0141 0.2159
Echinococcus granulosus cathepsin l1 0.0018 0.0012 0.0007
Echinococcus multilocularis GPCR, family 2 0.0119 0.0282 0.0277
Leishmania major trypanothione reductase 0.0054 0.0107 0.7074
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0091 0.0207 0.0302
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0012 0.0109
Toxoplasma gondii target of rapamycin (TOR), putative 0.0037 0.0063 0.2848
Giardia lamblia GTOR 0.005 0.0097 1
Onchocerca volvulus 0.0052 0.0104 0.1572
Loa Loa (eye worm) hypothetical protein 0.0021 0.0019 0.0192
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0017 0.0008 0.0199
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0008 0.0046
Schistosoma mansoni tar DNA-binding protein 0.0074 0.0163 0.0158
Trypanosoma brucei heat shock protein, putative 0.0038 0.0066 0.4199
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0008 0.0046
Trichomonas vaginalis heat shock protein, putative 0.003 0.0045 0.0631
Leishmania major 4-coumarate:coa ligase-like protein 0.0028 0.0038 0.2274
Mycobacterium tuberculosis Transcriptional regulatory repressor protein (TetR-family) EthR 0.2406 0.6421 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0063 0.0916
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0054 0.0107 0.0147
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0017 0.0008 0.0003
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0017 0.0008 0.0199
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0018 0.0012 0.0109
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0019 0.0013 0.039
Trichomonas vaginalis PIKK family atypical protein kinase 0.005 0.0097 0.1462
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0054 0.0108 0.0102
Echinococcus multilocularis tar DNA binding protein 0.0074 0.0163 0.0158
Loa Loa (eye worm) MH2 domain-containing protein 0.0025 0.0031 0.0309
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0025 0.0031 0.0025
Echinococcus granulosus thioredoxin glutathione reductase 0.0054 0.0107 0.0102
Trypanosoma brucei trypanothione reductase 0.0054 0.0107 0.7074
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0043 0.0604
Trypanosoma brucei PAB1-binding protein , putative 0.0027 0.0036 0.2134
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0035 0.048
Brugia malayi Cathepsin L-like precursor 0.0018 0.0012 0.0126
Brugia malayi MH2 domain containing protein 0.0368 0.0951 0.978
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0018 0.0012 0.0007
Loa Loa (eye worm) hypothetical protein 0.0021 0.0019 0.0192
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0012 0.0109
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0054 0.0108 0.0102
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0017 0.0008 0.0199
Trypanosoma brucei heat shock protein, putative 0.0038 0.0066 0.4199
Onchocerca volvulus Cathepsin L homolog 0.0018 0.0012 0.0109
Brugia malayi Papain family cysteine protease containing protein 0.0018 0.0012 0.0126
Echinococcus multilocularis cysteine protease 0.0018 0.0012 0.0007
Trichomonas vaginalis heat shock protein, putative 0.0023 0.0026 0.0333
Echinococcus granulosus peptidase Clp S14 family 0.006 0.0123 0.0118
Leishmania major cathepsin L-like protease 0.0018 0.0012 0.0475
Schistosoma mansoni cellular tumor antigen P53 0.0111 0.026 0.0255
Echinococcus multilocularis heat shock protein 90 0.0038 0.0066 0.0061
Loa Loa (eye worm) TAR-binding protein 0.0074 0.0163 0.1674
Treponema pallidum heat shock protein 90 0.003 0.0045 0.1636
Trypanosoma brucei heat shock protein, putative 0.0038 0.0066 0.4199
Schistosoma mansoni hypothetical protein 0.0041 0.0073 0.0068
Trypanosoma brucei heat shock protein, putative 0.0038 0.0066 0.4199
Trypanosoma cruzi major cysteine proteinase, putative 0.0054 0.011 0.7236
Trypanosoma cruzi trypanothione reductase, putative 0.0019 0.0013 0.0547
Loa Loa (eye worm) hypothetical protein 0.0028 0.0038 0.0387
Echinococcus granulosus cathepsin L cysteine proteinase 0.0018 0.0012 0.0007
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0054 0.0108 0.0102
Echinococcus granulosus survival motor neuron protein 1 0.0257 0.0653 0.0648
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0018 0.0012 0.012
Mycobacterium ulcerans hypothetical protein 0.0028 0.0038 0.0039
Onchocerca volvulus 0.0018 0.0012 0.0109
Loa Loa (eye worm) phosphatidylinositol 3 0.005 0.0097 0.0995
Echinococcus granulosus endoplasmin 0.003 0.0045 0.004
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0063 0.0916
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.0149 1
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0029 0.004 0.0035
Schistosoma mansoni tar DNA-binding protein 0.0074 0.0163 0.0158
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0017 0.0008 0.0003
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0136 0.0328 0.0454
Brugia malayi Endoplasmin precursor 0.0038 0.0066 0.0678
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0019 0.0013 0.039
Brugia malayi Doublecortin family protein 0.0066 0.0141 0.145
Echinococcus granulosus histone lysine methyltransferase setb 0.0031 0.0048 0.0042
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0012 0.0109
Schistosoma mansoni lamin 0.0059 0.0123 0.0117
Entamoeba histolytica hypothetical protein 0.0041 0.0073 0.7355
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0122 0.0292 0.0435
Echinococcus multilocularis mothers against decapentaplegic 5 0.0025 0.0031 0.0025
Echinococcus granulosus Polycystic kidney disease protein 0.0066 0.0141 0.0136
Schistosoma mansoni hypothetical protein 0.0052 0.0104 0.0099
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0008 0.0046
Echinococcus multilocularis Polycystic kidney disease protein 0.0066 0.0141 0.0136
Schistosoma mansoni smad1 5 8 and 0.0025 0.0031 0.0025
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0041 0.0073 0.0068
Loa Loa (eye worm) cysteine protease 0.0018 0.0012 0.012
Plasmodium falciparum heat shock protein 90 0.0038 0.0066 0.2996
Loa Loa (eye worm) hypothetical protein 0.0066 0.0141 0.1445
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.0149 1
Loa Loa (eye worm) hypothetical protein 0.0066 0.0141 0.1445
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0018 0.0012 0.0339
Leishmania major heat shock protein 83-1 0.0038 0.0066 0.4199
Trichomonas vaginalis heat shock protein, putative 0.0038 0.0066 0.0964
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.005 0.0097 0.637

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) = 8.5 % Cell cycle arrest in human HeLa cells by accumulation at G2/M phase at 5.0 uM after 24 hrs using PI staining by flow cytometry ChEMBL. 19091579
Activity (functional) = 9.3 % Cell cycle arrest in human HeLa cells by accumulation at G2/M phase at 10.0 uM after 24 hrs using PI staining by flow cytometry ChEMBL. 19091579
Activity (functional) = 13.6 % Cell cycle arrest in human HeLa cells by accumulation at G2/M phase at 2.5 uM after 24 hrs using PI staining by flow cytometry ChEMBL. 19091579
Activity (functional) = 32.5 % Induction of apoptosis in human HeLa cells assessed as apoptotic cells at 10 uM by flow cytometry ChEMBL. 19091579
Activity (functional) = 36.7 % Cell cycle arrest in human HeLa cells by accumulation at G1 phase at 10.0 uM after 24 hrs using PI staining by flow cytometry ChEMBL. 19091579
Activity (functional) = 39.4 % Cell cycle arrest in human HeLa cells by accumulation at S phase at 2.5 uM after 24 hrs using PI staining by flow cytometry ChEMBL. 19091579
Activity (functional) = 44.8 % Cell cycle arrest in human HeLa cells by accumulation at S phase at 5.0 uM after 24 hrs using PI staining by flow cytometry ChEMBL. 19091579
Activity (functional) = 46.7 % Cell cycle arrest in human HeLa cells by accumulation at G1 phase at 5.0 uM after 24 hrs using PI staining by flow cytometry ChEMBL. 19091579
Activity (functional) = 47 % Cell cycle arrest in human HeLa cells by accumulation at G1 phase at 2.5 uM after 24 hrs using PI staining by flow cytometry ChEMBL. 19091579
Activity (functional) = 54 % Cell cycle arrest in human HeLa cells by accumulation at S phase at 10.0 uM after 24 hrs using PI staining by flow cytometry ChEMBL. 19091579
IC50 (functional) = 2.24 uM Antiproliferative activity against human SKOV3 cells after 96 hrs by MTT assay ChEMBL. 19091579
IC50 (functional) = 2.62 uM Antiproliferative activity against human HeLa cells after 96 hrs by MTT assay ChEMBL. 19091579
IC50 (functional) = 8.3 uM Antiproliferative activity against human BGC823 cells after 96 hrs by MTT assay ChEMBL. 19091579
Inhibition (functional) = 56.32 % Antiproliferative activity against human BGC823 cells at 10 uM after 96 hrs by MTT assay ChEMBL. 19091579
Inhibition (functional) = 69.34 % Antiproliferative activity against human HeLa cells at 10 uM after 96 hrs by MTT assay ChEMBL. 19091579
Inhibition (functional) = 70.54 % Antiproliferative activity against human SKOV3 cells at 10 uM after 96 hrs by MTT assay ChEMBL. 19091579

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23 19091579

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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