Detailed information for compound 100720

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 340.272 | Formula: C13H17N4O5P
  • H donors: 3 H acceptors: 6 LogP: -0.81 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(NC(CP(=O)(O)O)Cn1cncn1)COc1ccccc1
  • InChi: 1S/C13H17N4O5P/c18-13(7-22-12-4-2-1-3-5-12)16-11(8-23(19,20)21)6-17-10-14-9-15-17/h1-5,9-11H,6-8H2,(H,16,18)(H2,19,20,21)
  • InChiKey: LWPVRQFHZOSLCV-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Cryptococcus neoformans var. neoformans B-3501A Imidazoleglycerol-phosphate dehydratase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Candida albicans Imidazole glycerol phosphate dehydratase Get druggable targets OG5_129258 All targets in OG5_129258
Candida albicans Imidazole glycerol phosphate dehydratase Get druggable targets OG5_129258 All targets in OG5_129258
Mycobacterium leprae Probable imidazole glycerol-phosphate dehydratase HisB Get druggable targets OG5_129258 All targets in OG5_129258
Mycobacterium ulcerans imidazoleglycerol-phosphate dehydratase Get druggable targets OG5_129258 All targets in OG5_129258
Mycobacterium tuberculosis Probable imidazole glycerol-phosphate dehydratase HisB Get druggable targets OG5_129258 All targets in OG5_129258
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Onchocerca volvulus Nanchung homolog Imidazoleglycerol-phosphate dehydratase   202 aa 162 aa 19.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0135 0.1747 0.2048
Loa Loa (eye worm) hypothetical protein 0.0089 0.1092 0.1279
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0135 0.1747 0.2725
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0083 0.1008 1
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0012 0.0011 0.0011
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0052 0.0568 0.1393
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0113 0.0546
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0113 0.009
Trypanosoma brucei hypothetical protein, conserved 0.0246 0.3304 0.8103
Loa Loa (eye worm) hypothetical protein 0.0023 0.0161 0.0189
Brugia malayi glutathione reductase 0.0038 0.038 0.0592
Schistosoma mansoni hypothetical protein 0.0184 0.2435 0.2435
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0014 0.0034 0.0034
Mycobacterium ulcerans citrate lyase beta subunit, CitE_2 0.0028 0.0241 0.0254
Loa Loa (eye worm) hypothetical protein 0.0012 0.0011 0.0013
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0346 0.0849
Trichomonas vaginalis glutathione reductase, putative 0.0013 0.0028 0.0039
Trichomonas vaginalis alpha-glucosidase, putative 0.0013 0.003 0.0041
Echinococcus multilocularis Smad4 0.0017 0.0076 0.0076
Brugia malayi Probable ClpP-like protease 0.0158 0.2068 0.3225
Loa Loa (eye worm) hypothetical protein 0.0028 0.0232 0.0272
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0018 0.0096 0.0096
Loa Loa (eye worm) cytochrome P450 family protein 0.0016 0.007 0.0082
Echinococcus multilocularis smad 0.0017 0.0076 0.0076
Loa Loa (eye worm) CYP4Cod1 0.0016 0.007 0.0082
Brugia malayi pyruvate kinase, muscle isozyme 0.0016 0.0064 0.01
Echinococcus granulosus importin subunit beta 1 0.0058 0.0656 0.0656
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0013 0.0028 0.007
Brugia malayi MH2 domain containing protein 0.0017 0.0076 0.0119
Brugia malayi MH1 domain containing protein 0.0017 0.0076 0.0119
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.005 0.0548 0.1284
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0043 0.0453 0.2192
Leishmania major 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0028 0.0241 0.0525
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.0028 0.007
Echinococcus multilocularis lamin 0.0028 0.0239 0.0239
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0346 0.0473
Plasmodium falciparum pyruvate kinase 2 0.0038 0.0383 0.1851
Brugia malayi hypothetical protein 0.0044 0.0465 0.0724
Echinococcus multilocularis lipoxygenase domain containing protein 0.0044 0.0465 0.0465
Echinococcus multilocularis musashi 0.0028 0.0239 0.0239
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0097 0.1205 0.1247
Echinococcus granulosus muscleblind protein 0.0455 0.6257 0.6257
Echinococcus multilocularis RUN 0.0044 0.0465 0.0465
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0113 0.0546
Loa Loa (eye worm) isocitrate dehydrogenase 0.0018 0.0096 0.0113
Brugia malayi Steroid receptor seven-up type 2 0.0023 0.0161 0.0251
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0466 0.6413 0.7516
Brugia malayi RNA, U transporter 1 0.0164 0.2157 0.3364
Schistosoma mansoni hypothetical protein 0.0048 0.0512 0.0512
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0087 0.1068 0.1102
Brugia malayi cytoplasmic intermediate filament protein 0.0015 0.0055 0.0085
Brugia malayi latrophilin 2 splice variant baaae 0.0103 0.129 0.2011
Plasmodium vivax thioredoxin reductase, putative 0.0038 0.038 0.1836
Echinococcus granulosus histone acetyltransferase KAT2B 0.0043 0.0453 0.0453
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0013 0.0028 0.003
Plasmodium falciparum glutathione reductase 0.0038 0.038 0.1836
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0346 0.0849
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0048 0.0512 0.0512
Echinococcus granulosus Polycystic kidney disease protein 0.0044 0.0465 0.0465
Brugia malayi hypothetical protein 0.0012 0.0011 0.0017
Brugia malayi Calcitonin receptor-like protein seb-1 0.015 0.1959 0.3056
Loa Loa (eye worm) hypothetical protein 0.0023 0.0161 0.0189
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0113 0.0277
Echinococcus granulosus lysosomal alpha glucosidase 0.0161 0.2113 0.2113
Echinococcus granulosus neutral alpha glucosidase AB 0.0036 0.0346 0.0346
Echinococcus multilocularis microtubule associated protein 2 0.0721 1 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0023 0.0161 0.0161
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0023 0.0161 0.0189
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0043 0.0441 0.4929
Brugia malayi MH2 domain containing protein 0.0017 0.0076 0.0119
Loa Loa (eye worm) hypothetical protein 0.0075 0.0895 0.1049
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0346 0.0473
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.005 0.0548 0.1284
Echinococcus granulosus neuropeptide s receptor 0.0502 0.6917 0.6917
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.005 0.0548 0.1345
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0135 0.1747 0.1747
Trichomonas vaginalis set domain proteins, putative 0.0531 0.7321 1
Loa Loa (eye worm) hypothetical protein 0.0455 0.6257 0.7333
Loa Loa (eye worm) hypothetical protein 0.0138 0.1789 0.2097
Echinococcus granulosus ecdysone induced protein 78C 0.0023 0.0161 0.0161
Echinococcus multilocularis pyruvate kinase 0.0075 0.0895 0.0895
Echinococcus granulosus histone acetyltransferase KAT2B 0.0143 0.1862 0.1862
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0013 0.003 0.0073
Brugia malayi N-terminal motif family protein 0.0215 0.2878 0.4488
Echinococcus multilocularis mitogen activated protein kinase 0.005 0.0548 0.0548
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0054 0.0609 0.1327
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0043 0.0453 0.2192
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0113 0.0209
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0074 0.0886 0.1931
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0043 0.0453 0.2192
Loa Loa (eye worm) inositol-1 0.0083 0.1008 0.1182
Treponema pallidum NADH oxidase 0.0013 0.0028 0.0137
Trypanosoma cruzi trypanothione reductase, putative 0.0038 0.038 0.0931
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0097 0.1205 0.1247
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0215 0.2878 0.3932
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0083 0.1008 0.2473
Loa Loa (eye worm) hypothetical protein 0.0028 0.0239 0.028
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0346 0.0473
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0023 0.0161 0.0251
Trypanosoma cruzi pyruvate kinase 2, putative 0.0075 0.0895 0.2196
Brugia malayi hypothetical protein 0.0049 0.0531 0.0828
Loa Loa (eye worm) hypothetical protein 0.0089 0.1092 0.1279
Giardia lamblia Pyruvate kinase 0.0075 0.0895 1
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0017 0.0076 0.0076
Loa Loa (eye worm) hypothetical protein 0.015 0.1959 0.2297
Schistosoma mansoni lipoxygenase 0.0185 0.2445 0.2445
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0158 0.2068 1
Toxoplasma gondii hypothetical protein 0.0048 0.0525 0.254
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0054 0.0609 0.2945
Leishmania major GTP-binding protein, putative 0.0043 0.0441 0.102
Toxoplasma gondii pyruvate kinase PyK1 0.0075 0.0895 0.4329
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0013 0.0028 0.007
Entamoeba histolytica pyruvate kinase, putative 0.0052 0.0577 0.5719
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0023 0.0161 0.0161
Brugia malayi Inositol-1 0.0083 0.1008 0.1572
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0113 0.0132
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0067 0.0785 0.0785
Echinococcus multilocularis lipoxygenase domain containing protein 0.0044 0.0465 0.0465
Brugia malayi MAP kinase sur-1 0.005 0.0548 0.0855
Brugia malayi hypothetical protein 0.0044 0.0465 0.0724
Loa Loa (eye worm) cytochrome P450 family protein 0.0016 0.007 0.0082
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0617 0.8532 1
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0548 0.0749
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0018 0.0096 0.0465
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0264 0.3566 0.3566
Plasmodium falciparum histone acetyltransferase GCN5 0.004 0.0402 0.1946
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0113 0.0113
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0147 0.192 0.192
Plasmodium vivax SET domain protein, putative 0.0067 0.0785 0.3794
Loa Loa (eye worm) hypothetical protein 0.0023 0.0161 0.0189
Onchocerca volvulus 0.0028 0.0239 0.0327
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0013 0.0028 0.007
Schistosoma mansoni microtubule-associated protein tau 0.0721 1 1
Trypanosoma brucei cytochrome P450, putative 0.0016 0.007 0.0172
Brugia malayi nuclear receptor RXR 0.0012 0.0011 0.0017
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0036 0.0346 0.3432
Brugia malayi Glycosyl hydrolases family 31 protein 0.0161 0.2113 0.3295
Trichomonas vaginalis mercuric reductase, putative 0.0013 0.0028 0.0039
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0113 0.0119
Leishmania major mitochondrial DNA polymerase beta 0.0301 0.4077 1
Loa Loa (eye worm) hypothetical protein 0.0044 0.0465 0.0545
Brugia malayi hypothetical protein 0.0089 0.1092 0.1702
Loa Loa (eye worm) hypothetical protein 0.0048 0.0512 0.06
Giardia lamblia Histone acetyltransferase GCN5 0.004 0.0402 0.4494
Schistosoma mansoni intermediate filament proteins 0.0028 0.0239 0.0239
Loa Loa (eye worm) hypothetical protein 0.0076 0.0909 0.1065
Mycobacterium ulcerans hypothetical protein 0.0028 0.0241 0.0254
Trypanosoma brucei protein kinase, putative 0.005 0.0548 0.1345
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0023 0.0161 0.0161
Echinococcus granulosus mothers against decapentaplegic 5 0.0017 0.0076 0.0076
Onchocerca volvulus Pyruvate kinase homolog 0.0075 0.0895 0.1223
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.0028 0.007
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0158 0.2068 1
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0158 0.2068 0.4507
Trypanosoma brucei PAB1-binding protein , putative 0.0076 0.0909 0.2229
Leishmania major pyruvate kinase 0.0075 0.0895 0.2141
Echinococcus granulosus thioredoxin glutathione reductase 0.0039 0.0387 0.0387
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0018 0.0096 0.0072
Echinococcus multilocularis neutral alpha glucosidase AB 0.0036 0.0346 0.0346
Loa Loa (eye worm) hypothetical protein 0.0023 0.0161 0.0189
Echinococcus multilocularis mothers against decapentaplegic 5 0.0017 0.0076 0.0076
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.0028 0.0241 0.0254
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0018 0.0096 0.0465
Echinococcus multilocularis pyruvate kinase 0.0075 0.0895 0.0895
Brugia malayi intermediate filament protein 0.0028 0.0239 0.0373
Echinococcus granulosus mitogen activated protein kinase 3 0.005 0.0548 0.0548
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0034 0.0321 0.0321
Loa Loa (eye worm) hypothetical protein 0.0013 0.003 0.0035
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0023 0.0161 0.0251
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0023 0.0161 0.0161
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0142 0.1846 0.4529
Echinococcus granulosus snurportin 1 0.0617 0.8532 0.8532
Trypanosoma cruzi importin beta-1 subunit, putative 0.0047 0.0502 0.1232
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0023 0.0161 0.0251
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0018 0.0096 0.0236
Echinococcus granulosus TGF beta signal transducer SmadC 0.0017 0.0076 0.0076
Brugia malayi Cytochrome P450 family protein 0.0016 0.007 0.0109
Brugia malayi Isocitrate dehydrogenase 0.0018 0.0096 0.015
Loa Loa (eye worm) hypothetical protein 0.0081 0.0979 0.1147
Echinococcus multilocularis neuropeptide receptor A26 0.0502 0.6917 0.6917
Brugia malayi pyruvate kinase 0.0016 0.0064 0.01
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0074 0.0886 0.0909
Echinococcus granulosus pyruvate kinase 0.0075 0.0895 0.0895
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0043 0.0441 0.1082
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0075 0.0895 0.0918
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.005 0.0548 0.1345
Echinococcus granulosus mitogen activated protein kinase 0.005 0.0548 0.0548
Schistosoma mansoni smad1 5 8 and 0.0017 0.0076 0.0076
Schistosoma mansoni eyes absent homolog 0.0089 0.1092 0.1092
Entamoeba histolytica hypothetical protein 0.0038 0.0372 0.3687
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0083 0.1008 0.1065
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0042 0.0438 0.1073
Brugia malayi hypothetical protein 0.0012 0.0011 0.0017
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0142 0.1846 0.449
Trypanosoma brucei pyruvate kinase 1, putative 0.0075 0.0895 0.2196
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0013 0.0028 0.0028
Schistosoma mansoni hypothetical protein 0.0103 0.129 0.129
Loa Loa (eye worm) hypothetical protein 0.0012 0.0011 0.0013
Schistosoma mansoni loxhd1 0.0044 0.0465 0.0465
Echinococcus granulosus neuropeptide receptor A26 0.0502 0.6917 0.6917
Toxoplasma gondii pyruvate kinase PyKII 0.0038 0.0383 0.1851
Onchocerca volvulus 0.0044 0.0465 0.0635
Schistosoma mansoni hypothetical protein 0.0038 0.0372 0.0372
Brugia malayi acetyltransferase, GNAT family protein 0.0147 0.192 0.2994
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0147 0.192 0.192
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0043 0.0441 0.1082
Schistosoma mansoni alpha-glucosidase 0.0139 0.1797 0.1797
Mycobacterium leprae Probable imidazole glycerol-phosphate dehydratase HisB 0.0337 0.4589 1
Echinococcus multilocularis geminin 0.0184 0.2435 0.2435
Schistosoma mansoni alpha-glucosidase 0.0139 0.1797 0.1797
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0087 0.1068 0.1102
Trypanosoma brucei glucosidase, putative 0.0036 0.0346 0.0849
Echinococcus granulosus histone lysine methyltransferase setb 0.0067 0.0785 0.0785
Echinococcus granulosus pyruvate kinase 0.0038 0.0383 0.0383
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0087 0.1068 0.1102
Echinococcus granulosus GPCR family 2 0.0048 0.0512 0.0512
Schistosoma mansoni ran 0.0043 0.0441 0.0441
Loa Loa (eye worm) hypothetical protein 0.0138 0.1789 0.2097
Trypanosoma cruzi PAB1-binding protein , putative 0.0076 0.0909 0.2229
Plasmodium vivax pyruvate kinase, putative 0.0075 0.0895 0.4329
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0023 0.0161 0.0161
Echinococcus multilocularis lysosomal alpha glucosidase 0.0161 0.2113 0.2113
Leishmania major alpha glucosidase II subunit, putative 0.0036 0.0346 0.0784
Trichomonas vaginalis importin beta-1, putative 0.0047 0.0502 0.0686
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0013 0.0028 0.007
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0264 0.3566 0.3566
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0023 0.0161 0.0251
Onchocerca volvulus Uncharacterized family 31 glucosidase KIAA1161 homolog 0.0013 0.003 0.0041
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0023 0.0161 0.0161
Trypanosoma brucei ULK family serine/threonine-protein kinase, putative 0.0011 0.0002 0.0006
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0548 0.0749
Plasmodium falciparum ataxin-2 like protein, putative 0.0076 0.0909 0.4395
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0013 0.0028 0.0028
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0113 0.0154
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0064 0.075 0.075
Brugia malayi Thioredoxin reductase 0.0038 0.038 0.0592
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0054 0.0609 0.2945
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0034 0.0321 0.0321
Schistosoma mansoni pyruvate kinase 0.0075 0.0895 0.0895
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0023 0.0161 0.0251
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0023 0.0161 0.0189
Onchocerca volvulus Huntingtin homolog 0.0138 0.1789 0.2444
Brugia malayi Pre-SET motif family protein 0.0466 0.6413 1
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0113 0.0154
Trypanosoma brucei importin beta-1 subunit, putative 0.0058 0.0656 0.1609
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0018 0.0096 0.0167
Schistosoma mansoni Smad4 0.0017 0.0076 0.0076
Loa Loa (eye worm) hypothetical protein 0.0012 0.0011 0.0013
Schistosoma mansoni polycystin 1-related 0.0044 0.0465 0.0465
Brugia malayi Doublecortin family protein 0.0044 0.0465 0.0724
Loa Loa (eye worm) pigment dispersing factor receptor c 0.015 0.1959 0.2297
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0301 0.4077 1
Brugia malayi Nuclear hormone receptor-like 1 0.0012 0.0011 0.0017
Brugia malayi Nuclear hormone receptor-like 1 0.0012 0.0011 0.0017
Trypanosoma cruzi PAB1-binding protein , putative 0.0076 0.0909 0.2229
Echinococcus granulosus smad 0.0017 0.0076 0.0076
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.0239 0.028
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.0096 0.0096
Echinococcus multilocularis peptidase Clp (S14 family) 0.0104 0.1301 0.1301
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0043 0.0441 0.2134
Brugia malayi Intermediate filament tail domain containing protein 0.0028 0.0239 0.0373
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0346 0.0473
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0158 0.2068 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0113 0.0277
Trypanosoma cruzi trypanothione reductase, putative 0.0013 0.0028 0.007
Trypanosoma brucei pyruvate kinase 1 0.0075 0.0895 0.2196
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0301 0.4077 1
Echinococcus multilocularis ecdysone induced protein 78C 0.0023 0.0161 0.0161
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0158 0.2068 0.2068
Onchocerca volvulus 0.0093 0.1155 0.1578
Plasmodium falciparum LCCL domain-containing protein 0.0044 0.0465 0.2247
Loa Loa (eye worm) hypothetical protein 0.0455 0.6257 0.7333
Leishmania major trypanothione reductase 0.0038 0.038 0.0868
Trichomonas vaginalis maltase-glucoamylase, putative 0.0036 0.0346 0.0473
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0013 0.0028 0.003
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0013 0.0028 0.0137
Echinococcus granulosus Smad4 0.0017 0.0076 0.0076
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0023 0.0161 0.0251
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0438 0.1073
Trichomonas vaginalis inositol monophosphatase, putative 0.0083 0.1008 0.1377
Mycobacterium ulcerans imidazoleglycerol-phosphate dehydratase 0.0683 0.9467 1
Schistosoma mansoni serine/threonine protein kinase 0.005 0.0548 0.0548
Schistosoma mansoni coup transcription factor 0.0023 0.0161 0.0161
Schistosoma mansoni ap endonuclease 0.0019 0.0113 0.0113
Schistosoma mansoni hypothetical protein 0.0617 0.8532 0.8532
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0013 0.0028 0.007
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0023 0.0161 0.0161
Trypanosoma cruzi hypothetical protein, conserved 0.0246 0.3304 0.8103
Loa Loa (eye worm) hypothetical protein 0.0023 0.0161 0.0189
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0113 0.0176
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0023 0.0161 0.022
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0013 0.003 0.0041
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0012 0.0011 0.0011
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0158 0.2068 1
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0087 0.1068 0.1102
Trypanosoma brucei trypanothione reductase 0.0038 0.038 0.0931
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0036 0.0346 0.3432
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0113 0.0546
Toxoplasma gondii LsmAD domain-containing protein 0.0076 0.0909 0.4395
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0013 0.0028 0.003
Brugia malayi isocitrate dehydrogenase 0.0018 0.0096 0.015
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0158 0.2068 0.2184
Echinococcus multilocularis neuropeptide s receptor 0.0502 0.6917 0.6917
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0023 0.0161 0.0189
Echinococcus granulosus pyruvate kinase 0.0038 0.0383 0.0383
Schistosoma mansoni RAR-like nuclear receptor 0.0023 0.0161 0.0161
Schistosoma mansoni lamin 0.0028 0.0239 0.0239
Echinococcus multilocularis importin subunit beta 1 0.0058 0.0656 0.0656
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0135 0.1747 0.1747
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0023 0.0161 0.0161
Plasmodium vivax pyruvate kinase 2, putative 0.0038 0.0383 0.1851
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0023 0.0161 0.0161
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0023 0.0161 0.0161
Schistosoma mansoni steroid hormone receptor ad4bp 0.0023 0.0161 0.0161
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0135 0.1747 0.1747
Loa Loa (eye worm) hypothetical protein 0.0023 0.0161 0.0189
Schistosoma mansoni smad 0.0017 0.0076 0.0076
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0016 0.007 0.0074
Schistosoma mansoni thyroid hormone receptor 0.0023 0.0161 0.0161
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0018 0.0096 0.0096
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0023 0.0161 0.0161
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0014 0.0034 0.0034
Trichomonas vaginalis sucrase-isomaltase, putative 0.0036 0.0346 0.0473
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0548 0.0749
Plasmodium falciparum thioredoxin reductase 0.0038 0.038 0.1836
Loa Loa (eye worm) hypothetical protein 0.0023 0.0161 0.0189
Trichomonas vaginalis maltase-glucoamylase, putative 0.0013 0.003 0.0041
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0135 0.1747 0.1747
Echinococcus multilocularis Polycystic kidney disease protein 0.0044 0.0465 0.0465
Echinococcus multilocularis lysosomal alpha glucosidase 0.0161 0.2113 0.2113
Schistosoma mansoni rab6-interacting 0.0044 0.0465 0.0465
Loa Loa (eye worm) MH2 domain-containing protein 0.0244 0.3277 0.3841
Giardia lamblia Kinase, CMGC MAPK 0.005 0.0548 0.6123
Trichomonas vaginalis bromodomain-containing protein, putative 0.0043 0.0453 0.0619
Echinococcus granulosus lipoxygenase domain containing protein 0.0044 0.0465 0.0465
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0012 0.0011 0.0011
Trypanosoma cruzi hypothetical protein, conserved 0.0246 0.3304 0.8103
Schistosoma mansoni importin beta-1 0.0058 0.0656 0.0656
Mycobacterium tuberculosis Probable imidazole glycerol-phosphate dehydratase HisB 0.0683 0.9467 1
Loa Loa (eye worm) hypothetical protein 0.0158 0.2068 0.2424
Mycobacterium tuberculosis Probable dehydrogenase 0.0087 0.1068 0.1102
Toxoplasma gondii NADPH-glutathione reductase 0.0013 0.0028 0.0137
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0036 0.0346 0.1673
Onchocerca volvulus 0.0067 0.0785 0.1072
Mycobacterium ulcerans hypothetical protein 0.0158 0.2073 0.219
Schistosoma mansoni peptidase Clp (S14 family) 0.0158 0.2068 0.2068
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0113 0.112
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0042 0.0438 0.1073
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0012 0.0011 0.0011
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0083 0.1008 0.4876
Echinococcus granulosus peptidase Clp S14 family 0.0104 0.1301 0.1301
Echinococcus multilocularis inositol monophosphatase 1 0.0083 0.1008 0.1008
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0023 0.0161 0.0189
Loa Loa (eye worm) MH2 domain-containing protein 0.0017 0.0076 0.0089
Brugia malayi Pyruvate kinase, M2 isozyme 0.0075 0.0895 0.1396
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0158 0.2068 1
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0113 0.0546
Trypanosoma brucei glycosyl hydrolase-like protein 0.0013 0.003 0.0073
Echinococcus multilocularis isocitrate dehydrogenase 0.0018 0.0096 0.0096
Echinococcus granulosus GTP binding nuclear protein Ran 0.0043 0.0441 0.0441
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.015 0.1959 0.3056
Loa Loa (eye worm) hypothetical protein 0.0058 0.0656 0.0769
Brugia malayi Pre-SET motif family protein 0.0067 0.0785 0.1223
Loa Loa (eye worm) hypothetical protein 0.0012 0.0011 0.0013
Toxoplasma gondii thioredoxin reductase 0.0038 0.038 0.1836
Echinococcus multilocularis snurportin 1 0.0617 0.8532 0.8532
Brugia malayi Cytochrome P450 family protein 0.0016 0.007 0.0109
Entamoeba histolytica hypothetical protein 0.0038 0.0372 0.3687
Loa Loa (eye worm) MH1 domain-containing protein 0.0017 0.0076 0.0089
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0135 0.1747 0.1747
Loa Loa (eye worm) pyruvate kinase 0.0016 0.0064 0.0075
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.005 0.0548 0.1345
Echinococcus multilocularis thyroid hormone receptor alpha 0.0023 0.0161 0.0161
Schistosoma mansoni smad1 5 8 and 0.0017 0.0076 0.0076
Schistosoma mansoni pyruvate kinase 0.0075 0.0895 0.0895
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0043 0.0441 0.0517
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0013 0.0028 0.0044
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0013 0.0028 0.0137
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0113 0.0277
Plasmodium vivax importin-beta 2, putative 0.0058 0.0656 0.3173
Schistosoma mansoni thyroid hormone receptor 0.0023 0.0161 0.0161
Trichomonas vaginalis pyruvate kinase, putative 0.0075 0.0895 0.1223
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0104 0.1301 0.1348
Schistosoma mansoni smad1 5 8 and 0.0017 0.0076 0.0076
Echinococcus granulosus citrate lyase subunit beta protein 0.0028 0.0241 0.0241
Mycobacterium ulcerans hypothetical protein 0.0028 0.0241 0.0254
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0013 0.0028 0.0028
Echinococcus multilocularis pyruvate kinase 0.0038 0.0383 0.0383
Plasmodium falciparum pyruvate kinase 0.0075 0.0895 0.4329
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0067 0.0785 0.3794
Onchocerca volvulus 0.0023 0.0161 0.022
Echinococcus multilocularis muscleblind protein 1 0.0455 0.6257 0.6257
Toxoplasma gondii isocitrate dehydrogenase 0.0018 0.0096 0.0465
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0023 0.0161 0.0251
Schistosoma mansoni alpha glucosidase 0.0036 0.0346 0.0346
Schistosoma mansoni hypothetical protein 0.0034 0.0321 0.0321
Trypanosoma cruzi cytochrome P450, putative 0.0016 0.007 0.0172
Onchocerca volvulus Pyruvate kinase homolog 0.0075 0.0895 0.1223
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0018 0.0096 0.0096
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0013 0.0028 0.0137
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0023 0.0161 0.0161
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.005 0.0548 0.2651
Brugia malayi nuclear hormone receptor 0.0023 0.0161 0.0251
Toxoplasma gondii exonuclease III APE 0.0019 0.0113 0.0546
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0023 0.0161 0.0161
Brugia malayi Latrophilin receptor protein 2 0.0048 0.0512 0.0799
Leishmania major hypothetical protein, conserved 0.0076 0.0909 0.2175
Brugia malayi photoreceptor-specific nuclear receptor 0.0023 0.0161 0.0251
Mycobacterium tuberculosis Conserved hypothetical protein 0.0158 0.2073 0.2166
Echinococcus multilocularis muscleblind protein 0.0455 0.6257 0.6257
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0036 0.0346 0.0405
Echinococcus granulosus FTZ F1 alpha 0.0023 0.0161 0.0161
Loa Loa (eye worm) pyruvate kinase 0.0075 0.0895 0.1049
Loa Loa (eye worm) hypothetical protein 0.0067 0.0785 0.092
Brugia malayi Nuclear hormone receptor-like 1 0.0023 0.0161 0.0251
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.005 0.0548 0.1345
Schistosoma mansoni hypothetical protein 0.0048 0.0512 0.0512
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0038 0.0372 0.0372
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0013 0.0028 0.0137
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0054 0.0609 0.2945
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0135 0.1747 0.1747
Schistosoma mansoni ap endonuclease 0.0019 0.0113 0.0113
Echinococcus multilocularis pyruvate kinase 0.0038 0.0383 0.0383
Trichomonas vaginalis alpha-glucosidase, putative 0.0013 0.003 0.0041
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0018 0.0096 0.0236
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0097 0.1205 0.2626
Plasmodium vivax multidomain scavenger receptor, putative 0.0044 0.0465 0.2247
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0067 0.0785 0.0785
Entamoeba histolytica hypothetical protein 0.0038 0.0372 0.3687
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0023 0.0161 0.0251
Loa Loa (eye worm) doublecortin family protein 0.0044 0.0465 0.0545
Schistosoma mansoni hypothetical protein 0.0184 0.2435 0.2435
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0038 0.0372 0.0372
Onchocerca volvulus Huntingtin homolog 0.0138 0.1789 0.2444
Brugia malayi MH1 domain containing protein 0.0017 0.0076 0.0119
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.0096 0.0096
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0083 0.1008 0.2473
Schistosoma mansoni ran 0.0043 0.0441 0.0441
Schistosoma mansoni inositol monophosphatase 0.0083 0.1008 0.1008
Echinococcus granulosus lamin 0.0028 0.0239 0.0239
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0067 0.0785 0.0785
Echinococcus granulosus inositol monophosphatase 1 0.0083 0.1008 0.1008
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0017 0.0076 0.0076
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0161 0.2113 0.2476
Loa Loa (eye worm) pyruvate kinase-PB 0.0052 0.0577 0.0676
Leishmania major pyruvate kinase 0.0075 0.0895 0.2141
Trichomonas vaginalis alpha-glucosidase, putative 0.0013 0.003 0.0041
Toxoplasma gondii hypothetical protein 0.0054 0.0609 0.2945
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0055 0.0064
Plasmodium falciparum glutathione reductase 0.0013 0.0028 0.0137
Loa Loa (eye worm) hypothetical protein 0.0012 0.0011 0.0013
Echinococcus granulosus intermediate filament protein 0.0028 0.0239 0.0239
Loa Loa (eye worm) hypothetical protein 0.0103 0.129 0.1511
Toxoplasma gondii isocitrate dehydrogenase 0.0018 0.0096 0.0465
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0047 0.0502 0.0686
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0083 0.1008 0.1377
Trichomonas vaginalis alpha-glucosidase, putative 0.0013 0.003 0.0041
Toxoplasma gondii HEAT repeat-containing protein 0.0058 0.0656 0.3173
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.005 0.0548 0.1345
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0083 0.1008 0.242
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0113 0.1261
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0048 0.0512 0.0799
Schistosoma mansoni lamin 0.0028 0.0239 0.0239
Echinococcus multilocularis thioredoxin glutathione reductase 0.0039 0.0387 0.0387
Trichomonas vaginalis Citrate lyase beta chain, putative 0.0028 0.0241 0.0329
Brugia malayi Glycosyl hydrolases family 31 protein 0.0036 0.0346 0.054
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0028 0.0241 0.059
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0104 0.1301 0.1348
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0023 0.0161 0.0189
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0012 0.0011 0.0013
Schistosoma mansoni inositol monophosphatase 0.0083 0.1008 0.1008
Onchocerca volvulus Bile acid receptor homolog 0.0023 0.0161 0.022
Schistosoma mansoni transcription factor LCR-F1 0.0038 0.0372 0.0372
Echinococcus multilocularis FTZ F1 alpha 0.0023 0.0161 0.0161
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0135 0.1747 0.1747
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0067 0.0785 0.0785
Schistosoma mansoni lipoxygenase 0.0264 0.3566 0.3566
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0013 0.0028 0.0137
Trypanosoma cruzi pyruvate kinase 2, putative 0.0075 0.0895 0.2196
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0043 0.0441 0.0688
Leishmania major cytochrome p450-like protein 0.0016 0.007 0.0103
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0023 0.0161 0.0251
Trichomonas vaginalis pyruvate kinase, putative 0.0075 0.0895 0.1223
Giardia lamblia NADH oxidase lateral transfer candidate 0.0013 0.0028 0.0317
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0023 0.0161 0.0161
Onchocerca volvulus Pyruvate kinase homolog 0.0075 0.0895 0.1223
Mycobacterium leprae Probable pyruvate kinase PykA 0.0075 0.0895 0.1951
Leishmania major hypothetical protein, conserved 0.0246 0.3304 0.809
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0023 0.0161 0.0161
Loa Loa (eye worm) thioredoxin reductase 0.0038 0.038 0.0445
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0013 0.0028 0.007
Leishmania major glycosyl hydrolase-like protein 0.0013 0.003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0044 0.0465 0.0545
Echinococcus multilocularis citrate lyase subunit beta protein 0.0028 0.0241 0.0241
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0087 0.1068 0.2328
Echinococcus granulosus pyruvate kinase 0.0075 0.0895 0.0895
Echinococcus multilocularis pyruvate kinase 0.0038 0.0383 0.0383
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.0028 0.007
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0067 0.0785 0.0785
Schistosoma mansoni hypothetical protein 0.0048 0.0512 0.0512
Echinococcus granulosus pyruvate kinase 0.0038 0.0383 0.0383
Plasmodium falciparum importin beta, putative 0.0058 0.0656 0.3173
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0023 0.0161 0.0189
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.0028 0.007
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0043 0.0441 0.0441
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.0096 0.0096
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0043 0.0453 0.0619
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0036 0.0346 0.0473
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0013 0.0028 0.0137
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0047 0.0502 0.0686
Loa Loa (eye worm) steroid hormone receptor 0.0023 0.0161 0.0189
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0023 0.0161 0.0161
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0048 0.0512 0.0512
Giardia lamblia Pyruvate kinase 0.0038 0.0383 0.4274
Loa Loa (eye worm) hypothetical protein 0.0013 0.0026 0.0031
Onchocerca volvulus Protein ultraspiracle homolog 0.0023 0.0161 0.022
Echinococcus granulosus lamin dm0 0.0028 0.0239 0.0239
Brugia malayi nuclear receptor NHR-88 0.0023 0.0161 0.0251
Entamoeba histolytica hypothetical protein 0.0038 0.0372 0.3687
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0023 0.0161 0.0189
Echinococcus multilocularis pyruvate kinase 0.0059 0.0673 0.0673
Loa Loa (eye worm) pyruvate kinase 0.0075 0.0895 0.1049
Schistosoma mansoni hypothetical protein 0.0048 0.0512 0.0512
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0067 0.0785 0.0785
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0023 0.0161 0.0251
Echinococcus granulosus lipoxygenase domain containing protein 0.0044 0.0465 0.0465
Schistosoma mansoni retinoic acid receptor RXR 0.0023 0.0161 0.0161
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0158 0.2068 1
Brugia malayi MH2 domain containing protein 0.0244 0.3277 0.5111
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0083 0.1008 0.4876
Mycobacterium tuberculosis Conserved protein 0.0028 0.0241 0.0225
Loa Loa (eye worm) acetyltransferase 0.0147 0.192 0.225
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.0028 0.007
Loa Loa (eye worm) transcription factor SMAD2 0.0244 0.3277 0.3841
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0104 0.1301 0.2835
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.005 0.0548 0.0642
Mycobacterium tuberculosis Probable reductase 0.0087 0.1068 0.1102
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0083 0.1008 0.1377
Brugia malayi hypothetical protein 0.0138 0.1789 0.279
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0023 0.0161 0.0251
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0043 0.0441 0.1082
Entamoeba histolytica Ran family GTPase 0.0043 0.0441 0.4377
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0043 0.0441 0.2134
Echinococcus multilocularis mitogen activated protein kinase 3 0.005 0.0548 0.0548
Mycobacterium tuberculosis Probable citrate (pro-3S)-lyase (beta subunit) CitE (citrase) (citratase) (citritase) (citridesmolase) (citrase aldolase) 0.0028 0.0241 0.0225
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.0028 0.0241 0.0254
Brugia malayi ecdysteroid receptor 0.0023 0.0161 0.0251
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0038 0.038 0.0372
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0158 0.2068 0.2184
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0048 0.0512 0.0512
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0013 0.003 0.0073
Plasmodium falciparum ataxin-2 like protein, putative 0.0076 0.0909 0.4395
Onchocerca volvulus 0.0044 0.0465 0.0635
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0158 0.2068 1
Echinococcus granulosus geminin 0.0184 0.2435 0.2435
Schistosoma mansoni nuclear hormone receptor 0.0023 0.0161 0.0161
Entamoeba histolytica acetyltransferase, GNAT family 0.004 0.0402 0.399
Brugia malayi hypothetical protein 0.0076 0.0909 0.1417
Loa Loa (eye worm) Smad1 0.0017 0.0076 0.0089
Brugia malayi Pyruvate kinase, alpha/beta domain containing protein 0.0023 0.0161 0.0251
Echinococcus multilocularis lamin dm0 0.0028 0.0239 0.0239
Leishmania major importin beta-1 subunit, putative 0.0047 0.0502 0.117
Loa Loa (eye worm) hypothetical protein 0.0052 0.0577 0.0676
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0036 0.0346 0.0473
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0158 0.2068 1
Schistosoma mansoni rab6-interacting 0.0044 0.0465 0.0465
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0023 0.0161 0.0161
Plasmodium vivax ataxin-2 like protein, putative 0.0076 0.0909 0.4395
Plasmodium falciparum thioredoxin reductase 0.0013 0.0028 0.0137
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0142 0.1846 0.4529
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0113 0.0113
Mycobacterium ulcerans pyruvate kinase 0.0075 0.0895 0.0946
Loa Loa (eye worm) latrophilin receptor protein 2 0.0048 0.0512 0.06
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0301 0.4077 1
Echinococcus multilocularis GPCR, family 2 0.0048 0.0512 0.0512
Schistosoma mansoni hypothetical protein 0.0044 0.0465 0.0465
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.0081 0.0979 0.9709
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0023 0.0161 0.0251
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0013 0.0028 0.0137
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0023 0.0161 0.0161
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0158 0.2068 0.2068
Brugia malayi Muscleblind-like protein 0.0455 0.6257 0.9757
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0013 0.003 0.0295
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0048 0.0512 0.0512
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0023 0.0161 0.0251
Brugia malayi Importin beta-1 subunit 0.0058 0.0656 0.1023
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.0081 0.0979 0.9709
Loa Loa (eye worm) hypothetical protein 0.0013 0.0026 0.0031
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0018 0.0096 0.0236
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0013 0.0028 0.0137
Mycobacterium tuberculosis Probable oxidoreductase 0.0097 0.1205 0.1247
Trypanosoma brucei importin beta-1 subunit, putative 0.0058 0.0656 0.1609
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0013 0.003 0.0041
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0438 0.1073
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0028 0.0241 0.059
Brugia malayi Pyruvate kinase, muscle isozyme 0.0075 0.0895 0.1396
Loa Loa (eye worm) pyruvate kinase 0.0075 0.0895 0.1049
Entamoeba histolytica hypothetical protein 0.0047 0.0502 0.4981
Loa Loa (eye worm) glutathione reductase 0.0038 0.038 0.0445
Brugia malayi Glycosyl hydrolases family 31 protein 0.0013 0.003 0.0046
Trypanosoma cruzi cytochrome P450, putative 0.0016 0.007 0.0172
Trichomonas vaginalis ran, putative 0.0043 0.0441 0.0603
Plasmodium vivax glutathione reductase, putative 0.0038 0.038 0.1836
Loa Loa (eye worm) hypothetical protein 0.0215 0.2878 0.3373
Brugia malayi steroid hormone receptor 0.0023 0.0161 0.0251
Onchocerca volvulus 0.0531 0.7321 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0013 0.003 0.0041
Schistosoma mansoni pyruvate kinase 0.0038 0.0383 0.0383
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0083 0.1008 0.2473
Brugia malayi hypothetical protein 0.0038 0.0372 0.058
Brugia malayi Smad1 0.0017 0.0076 0.0119
Onchocerca volvulus 0.0028 0.0239 0.0327
Loa Loa (eye worm) hypothetical protein 0.0023 0.0161 0.0189
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0018 0.0096 0.0236
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.0028 0.007
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0043 0.0441 0.2134
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0548 0.0749
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0346 0.0473
Loa Loa (eye worm) intermediate filament protein 0.0028 0.0239 0.028
Loa Loa (eye worm) hypothetical protein 0.0014 0.0034 0.0039
Chlamydia trachomatis pyruvate kinase 0.0075 0.0895 0.4329
Echinococcus granulosus RUN 0.0044 0.0465 0.0465
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0023 0.0161 0.0161

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 0.38 uM Inhibitory concentration against imidazole glycerol phosphate dehydratase (IGPD) from Cryptococcus neoformans ChEMBL. 10450980
IC50 (binding) = 0.38 uM Inhibitory concentration against imidazole glycerol phosphate dehydratase (IGPD) from Cryptococcus neoformans ChEMBL. 10450980
Ki (binding) = 0.08 uM Binding affinity imidazole glycerol phosphate dehydratase (IGPD) obtained from Cryptococcus neoformans ChEMBL. 10450980
Ki (binding) = 0.08 uM Binding affinity imidazole glycerol phosphate dehydratase (IGPD) obtained from Cryptococcus neoformans ChEMBL. 10450980
Kis (binding) = 0.27 uM Kinetic constant for the inhibition of imidazole glycerol phosphate dehydratase (IGPD) ChEMBL. 10450980
Kis (binding) = 0.27 uM Kinetic constant for the inhibition of imidazole glycerol phosphate dehydratase (IGPD) ChEMBL. 10450980

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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