Detailed information for compound 1008867

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 435.469 | Formula: C25H25NO6
  • H donors: 0 H acceptors: 3 LogP: 3.98 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOC(=O)c1c2CCc3c(c2c(n1Cc1ccc(cc1)C)C)oc(=O)c(c3)C(=O)OC
  • InChi: 1S/C25H25NO6/c1-5-31-25(29)21-18-11-10-17-12-19(23(27)30-4)24(28)32-22(17)20(18)15(3)26(21)13-16-8-6-14(2)7-9-16/h6-9,12H,5,10-11,13H2,1-4H3
  • InChiKey: UUCGYZHEHXZSJQ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0025 0.0168 0.0311
Echinococcus multilocularis Niemann Pick C1 protein 0.0103 0.1102 0.1102
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0617 0.0726
Plasmodium vivax hypothetical protein, conserved 0.0349 0.4056 1
Brugia malayi Pyruvate kinase, M2 isozyme 0.0036 0.0307 0.0756
Trichomonas vaginalis glucosylceramidase, putative 0.0126 0.1377 0.3248
Schistosoma mansoni transcription factor LCR-F1 0.0038 0.0321 0.0378
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.019 0.2146 0.5291
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0071 0.0725 0.0854
Brugia malayi Calcitonin receptor-like protein seb-1 0.0158 0.176 0.4339
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0057 0.0551 0.1358
Trichomonas vaginalis glucosylceramidase, putative 0.0119 0.13 0.3054
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0617 0.0726
Brugia malayi beta-lactamase 0.0039 0.0342 0.0844
Schistosoma mansoni microtubule-associated protein tau 0.0719 0.8491 1
Plasmodium falciparum SWIB/MDM2 domain-containing protein 0.0349 0.4056 1
Trichomonas vaginalis alpha-galactosidase/alpha-N-acetylgalactosaminidase, putative 0.0071 0.0725 0.1603
Echinococcus multilocularis tar DNA binding protein 0.0062 0.0617 0.0617
Toxoplasma gondii DNA topoisomerase domain-containing protein 0.0349 0.4056 1
Echinococcus multilocularis Glycoside hydrolase, family 27 0.0107 0.1151 0.1151
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0018 0.0089 0.0219
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0168 0.0235
Loa Loa (eye worm) hypothetical protein 0.0044 0.04 0.0985
Echinococcus granulosus importin subunit beta 1 0.0025 0.0167 0.0196
Loa Loa (eye worm) hypothetical protein 0.0039 0.0342 0.0844
Mycobacterium ulcerans 4-aminobutyrate aminotransferase 0.0023 0.0142 0.0153
Loa Loa (eye worm) hypothetical protein 0.0026 0.0187 0.0461
Echinococcus multilocularis pyruvate kinase 0.0029 0.0215 0.0215
Toxoplasma gondii ornithine aminotransferase, mitochondrial precursor, putative 0.0023 0.0142 0.0222
Toxoplasma gondii ran binding protein 0.0124 0.136 0.3266
Trichomonas vaginalis glucosylceramidase, putative 0.0119 0.13 0.3054
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0018 0.0093 0.0033
Brugia malayi hypothetical protein 0.0242 0.2773 0.6836
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0617 0.0726
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0032 0.026 0.0641
Mycobacterium ulcerans lipase LipD 0.0039 0.0342 0.0781
Trypanosoma cruzi mitochondrial RNA binding complex 1 subunit, putative 0.0124 0.136 1
Onchocerca volvulus Glucosylceramidase homolog 0.0119 0.13 0.3206
Mycobacterium tuberculosis Conserved protein 0.0039 0.0342 0.0934
Loa Loa (eye worm) transcription factor SMAD2 0.0121 0.1317 0.3248
Loa Loa (eye worm) SWIB/MDM2 domain-containing protein 0.0349 0.4056 1
Trypanosoma cruzi pyruvate kinase 2, putative 0.0036 0.0307 0.1715
Schistosoma mansoni hypothetical protein 0.0349 0.4056 0.4777
Mycobacterium tuberculosis Adenosylmethionine-8-amino-7-oxononanoate aminotransferase BioA 0.0158 0.1771 0.604
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.0236 0.0278
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0018 0.0089 0.0089
Brugia malayi hypothetical protein 0.0038 0.0321 0.0792
Mycobacterium tuberculosis Probable glutamate-1-semialdehyde 2,1-aminomutase HemL (GSA) (glutamate-1-semialdehyde aminotransferase) (GSA-at) 0.0023 0.0142 0.0217
Trichomonas vaginalis protein kinase inhibitor, putative 0.0065 0.0649 0.1411
Trichomonas vaginalis pyruvate kinase, putative 0.0036 0.0307 0.055
Loa Loa (eye worm) hypothetical protein 0.0054 0.0518 0.1278
Loa Loa (eye worm) DnaJ domain-containing protein 0.0065 0.0649 0.1599
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0306 0.1706
Plasmodium vivax SET domain protein, putative 0.0032 0.025 0.0407
Trichomonas vaginalis glucosylceramidase, putative 0.0119 0.13 0.3054
Echinococcus granulosus beta LACTamase domain containing family member 0.0039 0.0342 0.0403
Echinococcus multilocularis Upstream activation factor subunit UAF30 0.0349 0.4056 0.4056
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0025 0.0168 0.0235
Loa Loa (eye worm) hypothetical protein 0.0018 0.0093 0.023
Trichomonas vaginalis acetylornithine aminotransferase, putative 0.0158 0.1771 0.4239
Loa Loa (eye worm) hypothetical protein 0.0103 0.1102 0.2716
Onchocerca volvulus 0.0124 0.136 0.3354
Mycobacterium ulcerans L-lysine aminotransferase 0.0023 0.0142 0.0153
Brugia malayi Importin beta-1 subunit 0.0025 0.0167 0.0411
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0251 0.2878 1
Trichomonas vaginalis Importin beta-1 subunit, putative 0.002 0.0111 0.0056
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0107 0.1151 0.1356
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.019 0.2146 0.2527
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0107 0.1151 0.1356
Leishmania major pyruvate kinase 0.0036 0.0307 0.1662
Onchocerca volvulus Ubiquitin thioesterase ZRANB1 homolog 0.0124 0.136 0.3354
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.003 0.0235 0.0581
Echinococcus granulosus sterol regulatory element binding protein 0.0044 0.04 0.0471
Trichomonas vaginalis penicillin-binding protein, putative 0.0039 0.0342 0.0639
Schistosoma mansoni pyruvate kinase 0.0036 0.0307 0.0361
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0107 0.1151 0.1356
Toxoplasma gondii melibiase subfamily protein 0.0107 0.1151 0.2743
Brugia malayi SWIB/MDM2 domain containing protein 0.0349 0.4056 1
Echinococcus multilocularis ornithine aminotransferase 0.0023 0.0142 0.0142
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0128 0.14 0.4716
Trichomonas vaginalis glucosylceramidase, putative 0.0182 0.2049 0.4941
Loa Loa (eye worm) hypothetical protein 0.0124 0.136 0.3354
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.025 0.0295
Onchocerca volvulus 0.0251 0.2876 0.709
Toxoplasma gondii aldehyde dehydrogenase 0.0128 0.14 0.3366
Mycobacterium tuberculosis Conserved protein 0.0039 0.0342 0.0934
Plasmodium vivax acyl-CoA synthetase, putative 0.0018 0.0093 0.0011
Brugia malayi Intermediate filament tail domain containing protein 0.0057 0.0551 0.1358
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0018 0.0093 0.0033
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0168 0.0235
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0124 0.136 0.3354
Brugia malayi Melibiase family protein 0.0071 0.0725 0.1787
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.025 0.0295
Echinococcus multilocularis musashi 0.0057 0.0551 0.0551
Echinococcus granulosus tumor protein p63 0.0238 0.272 0.3204
Onchocerca volvulus 0.0039 0.0342 0.0844
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0039 0.0342 0.0844
Loa Loa (eye worm) hypothetical protein 0.0025 0.0175 0.0432
Loa Loa (eye worm) hypothetical protein 0.0025 0.0168 0.0414
Schistosoma mansoni pyruvate kinase 0.0036 0.0307 0.0361
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0025 0.0168 0.0161
Echinococcus granulosus zinc finger protein Ran binding 0.0124 0.136 0.1602
Schistosoma mansoni zinc finger protein 0.0124 0.136 0.1602
Echinococcus granulosus dnaJ subfamily C 6 0.0065 0.0649 0.0764
Schistosoma mansoni pyruvate kinase 0.0019 0.0095 0.0112
Onchocerca volvulus 0.0057 0.0551 0.1358
Echinococcus multilocularis protein patched 0.0044 0.04 0.04
Trichomonas vaginalis glutaminase, putative 0.0285 0.3286 0.8059
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0104 0.1121 0.132
Schistosoma mansoni inositol monophosphatase 0.0036 0.0306 0.036
Echinococcus multilocularis ring and YY1 binding protein 0.0124 0.136 0.136
Echinococcus multilocularis lamin dm0 0.0057 0.0551 0.0551
Echinococcus granulosus pyruvate kinase 0.0019 0.0095 0.0112
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0062 0.0617 0.152
Mycobacterium leprae conserved hypothetical protein 0.0039 0.0342 0.1232
Schistosoma mansoni hypothetical protein 0.0263 0.3019 0.3555
Schistosoma mansoni aldehyde dehydrogenase 0.0128 0.14 0.1649
Echinococcus multilocularis snurportin 1 0.0263 0.3019 0.3019
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0107 0.1151 0.1356
Echinococcus multilocularis Alpha N acetylgalactosaminidase 0.0107 0.1151 0.1151
Trichomonas vaginalis set domain proteins, putative 0.0251 0.2876 0.7025
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0168 0.0414
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0036 0.0307 0.0807
Mycobacterium tuberculosis Probable ornithine aminotransferase (N-terminus part) RocD1 (ornithine--oxo-acid aminotransferase) 0.0023 0.0142 0.0217
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.019 0.2146 0.2527
Echinococcus granulosus intermediate filament protein 0.0057 0.0551 0.0649
Brugia malayi Niemann-Pick C1 protein precursor 0.0103 0.1102 0.2716
Brugia malayi Pyruvate kinase, muscle isozyme 0.0036 0.0307 0.0756
Schistosoma mansoni lamin 0.0057 0.0551 0.0649
Chlamydia trachomatis SWIB complex protein 0.0349 0.4056 1
Echinococcus granulosus expressed conserved protein 0.0096 0.1027 0.1209
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0018 0.0089 0.0219
Brugia malayi Latrophilin receptor protein 2 0.005 0.0469 0.1157
Echinococcus multilocularis ornithine aminotransferase 0.0023 0.0142 0.0142
Schistosoma mansoni hypothetical protein 0.0042 0.0381 0.0448
Plasmodium vivax SWIB/MDM2 domain-containing protein, putative 0.0349 0.4056 1
Mycobacterium ulcerans esterase/lipase LipP 0.0039 0.0342 0.0781
Echinococcus granulosus microtubule associated protein 2 0.0719 0.8491 1
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0617 0.0726
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0182 0.2049 0.5052
Leishmania major hypothetical protein, conserved 0.0124 0.136 0.9695
Trypanosoma cruzi WLM domain containing protein, putative 0.0124 0.136 1
Mycobacterium ulcerans acetylornithine aminotransferase 0.0023 0.0142 0.0153
Trichomonas vaginalis glucosylceramidase, putative 0.0182 0.2049 0.4941
Loa Loa (eye worm) hypothetical protein 0.005 0.0469 0.1157
Trypanosoma brucei importin beta-1 subunit, putative 0.0025 0.0167 0.0612
Echinococcus granulosus GTP binding nuclear protein Ran 0.0018 0.0089 0.0105
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0018 0.0093 0.0033
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0039 0.0342 0.0844
Brugia malayi Pre-SET motif family protein 0.022 0.2511 0.6191
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0306 0.0547
Trypanosoma brucei mitochondrial RNA binding complex 1 subunit 0.0124 0.136 1
Entamoeba histolytica hypothetical protein 0.002 0.0111 0.0218
Schistosoma mansoni hypothetical protein 0.0349 0.4056 0.4777
Mycobacterium ulcerans pyruvate kinase 0.0036 0.0307 0.067
Brugia malayi RNA, U transporter 1 0.007 0.071 0.1751
Onchocerca volvulus 0.0039 0.0342 0.0844
Trichomonas vaginalis Importin beta-1 subunit, putative 0.002 0.0111 0.0056
Mycobacterium ulcerans 4-aminobutyrate aminotransferase 0.0023 0.0142 0.0153
Trypanosoma brucei hypothetical protein, conserved 0.0039 0.0342 0.1995
Loa Loa (eye worm) hypothetical protein 0.0039 0.0342 0.0844
Loa Loa (eye worm) intermediate filament protein 0.0057 0.0551 0.1358
Entamoeba histolytica hypothetical protein 0.0038 0.0321 0.2295
Loa Loa (eye worm) hypothetical protein 0.0018 0.0093 0.023
Mycobacterium tuberculosis Conserved protein 0.0039 0.0342 0.0934
Toxoplasma gondii exonuclease III APE 0.0018 0.0093 0.01
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0039 0.0342 0.0934
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0025 0.0168 0.0161
Mycobacterium ulcerans adenosylmethionine-8-amino-7-oxononanoate aminotransferase 0.0158 0.1771 0.5254
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0032 0.025 0.0493
Echinococcus granulosus ornithine aminotransferase 0.0023 0.0142 0.0167
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0015 0.0053 0.0062
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0039 0.0342 0.0403
Brugia malayi latrophilin 2 splice variant baaae 0.0108 0.1163 0.2866
Toxoplasma gondii ABC1 family protein 0.0039 0.0342 0.0723
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0027 0.0199 0.0235
Schistosoma mansoni RNA binding protein 0.0124 0.136 0.1602
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0036 0.0306 1
Onchocerca volvulus Pyruvate kinase homolog 0.0036 0.0307 0.0756
Schistosoma mansoni ap endonuclease 0.0018 0.0093 0.0109
Plasmodium falciparum SWIB/MDM2 domain-containing protein 0.0349 0.4056 1
Loa Loa (eye worm) pyruvate kinase 0.0036 0.0307 0.0756
Trypanosoma cruzi Zn-finger in Ran binding protein and others/FYVE zinc finger, putative 0.0124 0.136 1
Leishmania major hypothetical protein, conserved 0.0039 0.0342 0.1934
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0093 0.001
Trichomonas vaginalis glucosylceramidase, putative 0.0126 0.1377 0.3248
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0103 0.1102 1
Chlamydia trachomatis pyruvate kinase 0.0036 0.0307 0.0539
Echinococcus multilocularis survival motor neuron protein 1 0.0242 0.2773 0.2773
Trichomonas vaginalis pyruvate kinase, putative 0.0036 0.0307 0.055
Echinococcus granulosus inositol monophosphatase 1 0.0036 0.0306 0.036
Leishmania major hypothetical protein, conserved 0.0124 0.136 0.9695
Mycobacterium tuberculosis Probable esterase LipL 0.0039 0.0342 0.0934
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0039 0.0342 0.0403
Mycobacterium leprae PROBABLE ADENOSYLMETHIONINE-8-AMINO-7-OXONONANOATE AMINOTRANSFERASE BIOA 0.0158 0.1771 1
Schistosoma mansoni hypothetical protein 0.0065 0.0649 0.0764
Echinococcus granulosus Protein patched homolog 1 0.0044 0.04 0.0471
Trypanosoma cruzi mitochondrial RNA binding complex 1 subunit, putative 0.0124 0.136 1
Echinococcus multilocularis microtubule associated protein 2 0.0719 0.8491 0.8491
Loa Loa (eye worm) RNA binding protein 0.0062 0.0617 0.152
Mycobacterium ulcerans aldehyde dehydrogenase 0.0128 0.14 0.4094
Echinococcus granulosus ring and YY1 binding protein 0.0124 0.136 0.1602
Loa Loa (eye worm) hypothetical protein 0.0124 0.136 0.3354
Plasmodium falciparum zinc finger Ran-binding domain-containing protein 2, putative 0.0124 0.136 0.3205
Echinococcus multilocularis zinc finger protein Ran binding 0.0124 0.136 0.136
Schistosoma mansoni hypothetical protein 0.005 0.0469 0.0553
Trypanosoma brucei hypothetical protein, conserved 0.0124 0.136 1
Wolbachia endosymbiont of Brugia malayi acetylornithine transaminase protein 0.0023 0.0142 0.2294
Schistosoma mansoni hypothetical protein 0.0108 0.1163 0.1369
Schistosoma mansoni hypothetical protein 0.005 0.0469 0.0553
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0032 0.025 0.025
Schistosoma mansoni hypothetical protein 0.0124 0.136 0.1602
Trypanosoma brucei importin beta-1 subunit, putative 0.0025 0.0167 0.0612
Onchocerca volvulus 0.0124 0.136 0.3354
Schistosoma mansoni hypothetical protein 0.0042 0.0381 0.0448
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0263 0.3019 0.7443
Plasmodium falciparum importin beta, putative 0.0025 0.0167 0.0196
Loa Loa (eye worm) hypothetical protein 0.0158 0.176 0.4339
Mycobacterium ulcerans ornithine aminotransferase RocD1 and RocD2 0.0023 0.0142 0.0153
Brugia malayi cytoplasmic intermediate filament protein 0.003 0.0235 0.0581
Brugia malayi brahma associated protein 60 kDa 0.0349 0.4056 1
Echinococcus multilocularis lamin 0.0057 0.0551 0.0551
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0032 0.025 0.025
Schistosoma mansoni hypothetical protein 0.005 0.0469 0.0553
Chlamydia trachomatis glutamate-1-semialdehyde-2,1-aminomutase 0.0023 0.0142 0.0123
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0158 0.176 0.4339
Loa Loa (eye worm) hypothetical protein 0.0108 0.1163 0.2866
Loa Loa (eye worm) hypothetical protein 0.0242 0.2773 0.6836
Loa Loa (eye worm) glutaminase 0.0285 0.3286 0.8102
Plasmodium vivax pyruvate kinase 2, putative 0.0019 0.0095 0.0016
Toxoplasma gondii pyruvate kinase PyK1 0.0036 0.0307 0.0634
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0093 0.001
Onchocerca volvulus 0.0025 0.0168 0.0414
Plasmodium vivax importin-beta 2, putative 0.0025 0.0167 0.0196
Leishmania major importin beta-1 subunit, putative 0.002 0.0111 0.0168
Echinococcus multilocularis inositol monophosphatase 1 0.0036 0.0306 0.0306
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0071 0.0725 0.0854
Trichomonas vaginalis glucosylceramidase, putative 0.0182 0.2049 0.4941
Loa Loa (eye worm) hypothetical protein 0.0124 0.136 0.3354
Schistosoma mansoni glutaminase 0.0285 0.3286 0.387
Trypanosoma brucei hypothetical protein, conserved 0.0124 0.136 1
Mycobacterium ulcerans hypothetical protein 0.0039 0.0342 0.0781
Mycobacterium leprae Probable pyruvate kinase PykA 0.0036 0.0307 0.1013
Onchocerca volvulus 0.0124 0.136 0.3354
Brugia malayi RNA binding protein 0.0062 0.0617 0.152
Echinococcus granulosus Zinc finger RanBP2 type 0.0124 0.136 0.1602
Schistosoma mansoni intermediate filament proteins 0.0057 0.0551 0.0649
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0617 0.0726
Mycobacterium ulcerans hypothetical protein 0.0158 0.1771 0.5254
Toxoplasma gondii HEAT repeat-containing protein 0.0025 0.0167 0.0284
Echinococcus granulosus survival motor neuron protein 1 0.0242 0.2773 0.3266
Trichomonas vaginalis inositol monophosphatase, putative 0.0036 0.0306 0.0547
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0128 0.14 0.1649
Toxoplasma gondii Zn-finger in Ran binding protein and others domain-containing protein 0.0124 0.136 0.3266
Loa Loa (eye worm) hypothetical protein 0.0018 0.0093 0.023
Onchocerca volvulus 0.0032 0.025 0.0617
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0342 0.0639
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0128 0.14 0.14
Trichomonas vaginalis esterase, putative 0.0039 0.0342 0.0639
Schistosoma mansoni aldehyde dehydrogenase 0.0128 0.14 0.1649
Schistosoma mansoni importin beta-1 0.0025 0.0167 0.0196
Echinococcus granulosus pyruvate kinase 0.0036 0.0307 0.0361
Schistosoma mansoni TRABID protein (C64 family) 0.0124 0.136 0.1602
Plasmodium falciparum ornithine aminotransferase 0.0023 0.0142 0.0134
Schistosoma mansoni ran 0.0018 0.0089 0.0105
Leishmania major pyruvate kinase 0.0036 0.0307 0.1662
Mycobacterium tuberculosis Probable aminotransferase 0.0158 0.1771 0.604
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.019 0.2146 0.2527
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0168 0.0414
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0342 0.0639
Trichomonas vaginalis glucosylceramidase, putative 0.0119 0.13 0.3054
Echinococcus granulosus Upstream activation factor subunit UAF30 0.0349 0.4056 0.4777
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0168 0.0604
Plasmodium falciparum pyruvate kinase 0.0036 0.0307 0.055
Echinococcus multilocularis SWI:SNF matrix associated 0.0349 0.4056 0.4056
Trypanosoma cruzi Zn-finger in Ran binding protein and others, putative 0.0124 0.136 1
Trypanosoma cruzi hypothetical protein, conserved 0.0124 0.136 1
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0342 0.1995
Echinococcus multilocularis pyruvate kinase 0.0036 0.0307 0.0307
Echinococcus multilocularis sterol regulatory element binding protein 0.0044 0.04 0.04
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0025 0.0168 0.0235
Brugia malayi Inositol-1 0.0036 0.0306 0.0754
Trypanosoma cruzi importin beta-1 subunit, putative 0.002 0.0111 0.0174
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0124 0.136 0.3354
Schistosoma mansoni ap endonuclease 0.0018 0.0093 0.0109
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0158 0.176 0.4339
Onchocerca volvulus 0.0049 0.0464 0.1143
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0093 0.0093
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0018 0.0093 0.0041
Echinococcus multilocularis importin subunit beta 1 0.0025 0.0167 0.0167
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0049 0.0464 0.1143
Mycobacterium tuberculosis Probable lipase LipE 0.0039 0.0342 0.0934
Mycobacterium tuberculosis Probable lipase LipD 0.0039 0.0342 0.0934
Echinococcus granulosus lamin dm0 0.0057 0.0551 0.0649
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0093 0.0229
Mycobacterium tuberculosis Probable hydrolase 0.0039 0.0342 0.0934
Giardia lamblia Pyruvate kinase 0.0036 0.0307 1
Echinococcus multilocularis beta LACTamase domain containing family member 0.0039 0.0342 0.0342
Trichomonas vaginalis glucosylceramidase, putative 0.0119 0.13 0.3054
Onchocerca volvulus 0.0035 0.0289 0.0712
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.005 0.0469 0.0553
Brugia malayi beta-lactamase family protein 0.0039 0.0342 0.0844
Trypanosoma cruzi WLM domain containing protein, putative 0.0124 0.136 1
Onchocerca volvulus Pyruvate kinase homolog 0.0036 0.0307 0.0756
Onchocerca volvulus 0.0349 0.4056 1
Schistosoma mansoni ornithine--oxo-acid transaminase 0.0023 0.0142 0.0167
Leishmania major hypothetical protein, conserved 0.0124 0.136 0.9695
Trichomonas vaginalis glucosylceramidase, putative 0.0119 0.13 0.3054
Giardia lamblia Pyruvate kinase 0.0019 0.0095 0.0289
Entamoeba histolytica acyl-CoA synthetase, putative 0.0025 0.0168 0.0782
Loa Loa (eye worm) hypothetical protein 0.0027 0.0199 0.0492
Plasmodium falciparum pyruvate kinase 2 0.0019 0.0095 0.0016
Schistosoma mansoni inositol monophosphatase 0.0036 0.0306 0.036
Plasmodium vivax pyruvate kinase, putative 0.0036 0.0307 0.055
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0342 0.1995
Echinococcus multilocularis geminin 0.0166 0.1864 0.1864
Trypanosoma brucei pyruvate kinase 1 0.0036 0.0307 0.1715
Echinococcus multilocularis SWI:SNF matrix associated 0.0349 0.4056 0.4056
Brugia malayi Pre-SET motif family protein 0.0032 0.025 0.0617
Schistosoma mansoni patched 1 0.0044 0.04 0.0471
Schistosoma mansoni fusion 0.0124 0.136 0.1602
Echinococcus multilocularis GPCR, family 2 0.005 0.0469 0.0469
Schistosoma mansoni cellular tumor antigen P53 0.0035 0.0289 0.034
Schistosoma mansoni brg-1 associated factor 0.0349 0.4056 0.4777
Echinococcus multilocularis Nuclear pore complex protein Nup153 0.0124 0.136 0.136
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0044 0.04 0.0985
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0018 0.0093 0.0043
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0168 0.0604
Loa Loa (eye worm) pyruvate kinase 0.0036 0.0307 0.0756
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0039 0.0342 0.0934
Loa Loa (eye worm) pyruvate kinase 0.0036 0.0307 0.0756
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0036 0.0306 0.2142
Trypanosoma cruzi Zn-finger in Ran binding protein and others, putative 0.0124 0.136 1
Entamoeba histolytica hypothetical protein 0.0038 0.0321 0.2295
Echinococcus multilocularis tumor protein p63 0.0238 0.272 0.272
Trypanosoma brucei Zn-finger in Ran binding protein and others/FYVE zinc finger, putative 0.0124 0.136 1
Loa Loa (eye worm) glutaminase 2 0.0285 0.3286 0.8102
Loa Loa (eye worm) hypothetical protein 0.0057 0.0551 0.1358
Echinococcus multilocularis Zinc finger, RanBP2 type 0.0124 0.136 0.136
Loa Loa (eye worm) inositol-1 0.0036 0.0306 0.0754
Echinococcus granulosus pyruvate kinase 0.0019 0.0095 0.0112
Echinococcus multilocularis pyruvate kinase 0.0019 0.0095 0.0095
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0342 0.0639
Echinococcus granulosus geminin 0.0166 0.1864 0.2195
Mycobacterium ulcerans hypothetical protein 0.0025 0.0168 0.0235
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.019 0.2146 0.5291
Loa Loa (eye worm) hypothetical protein 0.013 0.1425 0.3514
Leishmania major hypothetical protein, conserved 0.0124 0.136 0.9695
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0018 0.0093 0.0032
Entamoeba histolytica hypothetical protein 0.0038 0.0321 0.2295
Echinococcus multilocularis dnaJ subfamily C 6 0.0065 0.0649 0.0649
Entamoeba histolytica hypothetical protein 0.0038 0.0321 0.2295
Echinococcus granulosus Niemann Pick C1 protein 0.0147 0.1629 0.1919
Loa Loa (eye worm) hypothetical protein 0.0018 0.0093 0.023
Echinococcus multilocularis pyruvate kinase 0.0036 0.0307 0.0307
Trypanosoma brucei pyruvate kinase 1, putative 0.0036 0.0307 0.1715
Brugia malayi YY1-associated factor 2 0.0124 0.136 0.3354
Schistosoma mansoni hypothetical protein 0.0049 0.0464 0.0546
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0168 0.0235
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0124 0.136 0.3354
Loa Loa (eye worm) hypothetical protein 0.013 0.1425 0.3514
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.019 0.2146 0.2527
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0018 0.0089 0.009
Mycobacterium leprae Probable lipase LipE 0.0039 0.0342 0.1232
Echinococcus granulosus Aminotransferase class III 0.0023 0.0142 0.0167
Schistosoma mansoni hypothetical protein 0.0166 0.1864 0.2195
Loa Loa (eye worm) beta-lactamase 0.0039 0.0342 0.0844
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0306 0.1706
Echinococcus granulosus pyruvate kinase 0.0036 0.0307 0.0361
Mycobacterium tuberculosis Probable L-lysine-epsilon aminotransferase Lat (L-lysine aminotransferase) (lysine 6-aminotransferase) 0.0023 0.0142 0.0217
Treponema pallidum exodeoxyribonuclease (exoA) 0.0018 0.0093 0.5
Schistosoma mansoni hypothetical protein 0.005 0.0469 0.0553
Trichomonas vaginalis conserved hypothetical protein 0.0349 0.4056 1
Echinococcus granulosus Niemann Pick C1 protein 0.0103 0.1102 0.1297
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0168 0.0604
Schistosoma mansoni hypothetical protein 0.0042 0.0381 0.0448
Trichomonas vaginalis glucosylceramidase, putative 0.0182 0.2049 0.4941
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0128 0.14 1
Onchocerca volvulus Pyruvate kinase homolog 0.0036 0.0307 0.0756
Echinococcus granulosus GPCR family 2 0.005 0.0469 0.0553
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.019 0.2146 0.2527
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0306 0.1706
Loa Loa (eye worm) hypothetical protein 0.0018 0.0093 0.023
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0025 0.0168 0.0311
Schistosoma mansoni ran 0.0018 0.0089 0.0105
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.005 0.0469 0.1157
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0038 0.0321 0.0321
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0032 0.026 0.0728
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0027 0.0199 0.0199
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0018 0.0093 0.019
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.019 0.2146 0.2146
Entamoeba histolytica pyruvate kinase, putative 0.0025 0.0175 0.0853
Mycobacterium ulcerans glutamate-1-semialdehyde aminotransferase 0.0023 0.0142 0.0153
Schistosoma mansoni hypothetical protein 0.0038 0.0321 0.0378
Loa Loa (eye worm) hypothetical protein 0.0039 0.0342 0.0844
Entamoeba histolytica acyl-CoA synthetase, putative 0.0025 0.0168 0.0782
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0168 0.0414
Echinococcus granulosus SWI:SNF matrix associated 0.0349 0.4056 0.4777
Loa Loa (eye worm) brahma associated protein 0.0349 0.4056 1
Echinococcus multilocularis Aminotransferase class III 0.0023 0.0142 0.0142
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.025 0.0295
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0306 0.1654
Onchocerca volvulus 0.0039 0.0342 0.0844
Loa Loa (eye worm) hypothetical protein 0.0036 0.0307 0.0756
Echinococcus granulosus pyruvate kinase 0.0019 0.0095 0.0112
Brugia malayi CHE-14 protein 0.0044 0.04 0.0985
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0039 0.0342 0.0934
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0124 0.136 0.3354
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0039 0.0342 0.0781
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0025 0.0168 0.0235
Brugia malayi RNA recognition motif domain containing protein 0.0062 0.0617 0.152
Trichomonas vaginalis glucosylceramidase, putative 0.0182 0.2049 0.4941
Loa Loa (eye worm) hypothetical protein 0.0026 0.0187 0.0461
Toxoplasma gondii pyruvate kinase PyKII 0.0019 0.0095 0.0105
Brugia malayi glutaminase DH11.1 0.0285 0.3286 0.8102
Loa Loa (eye worm) hypothetical protein 0.0124 0.136 0.3354
Brugia malayi brahma associated protein 60 kDa 0.0349 0.4056 1
Chlamydia trachomatis DNA topoisomerase I 0.0349 0.4056 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.019 0.2146 0.2146
Schistosoma mansoni hypothetical protein 0.0166 0.1864 0.2195
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0093 0.001
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.005 0.0469 0.0469
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.022 0.2511 0.6191
Loa Loa (eye worm) hypothetical protein 0.0025 0.0168 0.0414
Echinococcus multilocularis protein dispatched 1 0.005 0.0474 0.0474
Brugia malayi intermediate filament protein 0.0057 0.0551 0.1358
Echinococcus multilocularis pyruvate kinase 0.0019 0.0095 0.0095
Schistosoma mansoni survival motor neuron protein 0.0049 0.0464 0.0546
Loa Loa (eye worm) hypothetical protein 0.0124 0.136 0.3354
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.005 0.0469 0.0469
Loa Loa (eye worm) hypothetical protein 0.0032 0.025 0.0617
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0036 0.0306 0.0632
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0182 0.2049 0.5052
Loa Loa (eye worm) hypothetical protein 0.0035 0.0289 0.0712
Schistosoma mansoni hypothetical protein 0.0042 0.0381 0.0448
Loa Loa (eye worm) TAR-binding protein 0.0062 0.0617 0.152
Brugia malayi TAR-binding protein 0.0062 0.0617 0.152
Brugia malayi 4-aminobutyrate aminotransferase, mitochondrial precursor 0.0023 0.0142 0.035
Brugia malayi hypothetical protein 0.013 0.1425 0.3514
Echinococcus granulosus Nuclear pore complex protein Nup153 0.0124 0.136 0.1602
Echinococcus multilocularis expressed conserved protein 0.0096 0.1027 0.1027
Echinococcus multilocularis pyruvate kinase 0.0019 0.0095 0.0095
Entamoeba histolytica acyl-coA synthetase, putative 0.0025 0.0168 0.0782
Trypanosoma cruzi pyruvate kinase 2, putative 0.0036 0.0307 0.1715
Loa Loa (eye worm) hypothetical protein 0.0025 0.0167 0.0411
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0093 0.0229
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0036 0.0306 0.0666
Echinococcus granulosus lamin 0.0057 0.0551 0.0649
Toxoplasma gondii SWIB/MDM2 domain-containing protein 0.0349 0.4056 1
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0093 0.0109
Brugia malayi MH2 domain containing protein 0.0121 0.1317 0.3248
Mycobacterium ulcerans beta-lactamase 0.0039 0.0342 0.0781
Trypanosoma cruzi hypothetical protein, conserved 0.0124 0.136 1
Mycobacterium ulcerans glutaminase 0.0285 0.3286 1
Brugia malayi DnaJ domain containing protein 0.0065 0.0649 0.1599
Loa Loa (eye worm) hypothetical protein 0.0056 0.0538 0.1327
Trichomonas vaginalis penicillin-binding protein, putative 0.0039 0.0342 0.0639
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0038 0.0321 0.0378
Plasmodium vivax hypothetical protein, conserved 0.0039 0.0342 0.0639
Echinococcus granulosus tar DNA binding protein 0.0062 0.0617 0.0726
Loa Loa (eye worm) hypothetical protein 0.0039 0.0342 0.0844
Trypanosoma cruzi hypothetical protein, conserved 0.0124 0.136 1
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0306 0.0547
Loa Loa (eye worm) hypothetical protein 0.0039 0.0342 0.0844
Echinococcus multilocularis SWI:SNF matrix associated 0.0349 0.4056 0.4056
Loa Loa (eye worm) MH2 domain-containing protein 0.0121 0.1317 0.3248
Onchocerca volvulus Huntingtin homolog 0.013 0.1425 0.3514
Onchocerca volvulus Huntingtin homolog 0.013 0.1425 0.3514
Loa Loa (eye worm) hypothetical protein 0.0039 0.0342 0.0844
Trichomonas vaginalis glucosylceramidase, putative 0.0182 0.2049 0.4941
Echinococcus multilocularis Niemann Pick C1 protein 0.0147 0.1629 0.1629
Onchocerca volvulus 0.0057 0.0551 0.1358
Echinococcus granulosus histone lysine methyltransferase setb 0.0032 0.025 0.0295
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.04 0.0783
Loa Loa (eye worm) pyruvate kinase-PB 0.0025 0.0175 0.0432
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0018 0.0093 0.0043
Loa Loa (eye worm) hypothetical protein 0.0071 0.0725 0.1787
Echinococcus granulosus Alpha N acetylgalactosaminidase 0.0107 0.1151 0.1356
Onchocerca volvulus 0.0124 0.136 0.3354
Plasmodium vivax ornithine aminotransferase, putative 0.0023 0.0142 0.0134
Leishmania major hypothetical protein, conserved 0.0124 0.136 0.9695
Trichomonas vaginalis glucosylceramidase, putative 0.0119 0.13 0.3054
Mycobacterium tuberculosis Probable acetylornithine aminotransferase ArgD 0.0023 0.0142 0.0217
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.005 0.0469 0.0553
Loa Loa (eye worm) latrophilin receptor protein 2 0.005 0.0469 0.1157
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0032 0.025 0.0295
Mycobacterium ulcerans aldehyde dehydrogenase 0.0128 0.14 0.4094
Mycobacterium ulcerans aldehyde dehydrogenase 0.0128 0.14 0.4094
Schistosoma mansoni lamin 0.0057 0.0551 0.0649
Schistosoma mansoni hypothetical protein 0.0349 0.4056 0.4777
Plasmodium falciparum acyl-CoA synthetase 0.0018 0.0093 0.0011
Echinococcus granulosus snurportin 1 0.0263 0.3019 0.3555
Brugia malayi beta-lactamase family protein 0.0039 0.0342 0.0844
Brugia malayi Pyruvate kinase, alpha/beta domain containing protein 0.0011 0.0003 0.0008
Loa Loa (eye worm) hypothetical protein 0.0025 0.0168 0.0414
Trichomonas vaginalis importin beta-1, putative 0.002 0.0111 0.0056
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0093 0.001
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0025 0.0168 0.0235

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 16.6 uM Phototoxicity against human K562 cells exposed to irradiation with 3.75 J/cm'2 UVA light prior to 72 hrs drug exposure by MTT assay ChEMBL. 19230658
IC50 (functional) = 17.8 uM Phototoxicity against human Jurkat cells exposed to irradiation with 3.75 J/cm'2 UVA light prior to 72 hrs drug exposure by MTT assay ChEMBL. 19230658
IC50 (functional) > 20 uM Cytotoxicity against human LoVo cells after 72 hrs by MTT assay ChEMBL. 19230658
IC50 (functional) > 20 uM Phototoxicity against human LoVo cells exposed to irradiation with 2.5 J/cm'2 UVA light prior to 72 hrs drug exposure by MTT assay ChEMBL. 19230658
IC50 (functional) > 20 uM Phototoxicity against human LoVo cells exposed to irradiation with 3.75 J/cm'2 UVA light prior to 72 hrs drug exposure by MTT assay ChEMBL. 19230658
IC50 (functional) > 20 uM Cytotoxicity against human K562 cells after 72 hrs by MTT assay ChEMBL. 19230658
IC50 (functional) > 20 uM Phototoxicity against human K562 cells exposed to irradiation with 2.5 J/cm'2 UVA light prior to 72 hrs drug exposure by MTT assay ChEMBL. 19230658
IC50 (functional) > 20 uM Cytotoxicity against human Jurkat cells after 72 hrs by MTT assay ChEMBL. 19230658
IC50 (functional) > 20 uM Phototoxicity against human Jurkat cells exposed to irradiation with 2.5 J/cm'2 UVA light prior to 72 hrs drug exposure by MTT assay ChEMBL. 19230658

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23 19230658

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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