Detailed information for compound 101697

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 475.305 | Formula: C13H25N4O11P2+
  • H donors: 5 H acceptors: 7 LogP: -4.68 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: O[C@@H]1C(O[C@H]([C@H]1O)n1ccc(nc1=O)N)OP(=O)(OP(=O)(OCC[N+](C)(C)C)O)O
  • InChi: 1S/C13H24N4O11P2/c1-17(2,3)6-7-25-29(21,22)28-30(23,24)27-12-10(19)9(18)11(26-12)16-5-4-8(14)15-13(16)20/h4-5,9-12,18-19H,6-7H2,1-3H3,(H3-,14,15,20,21,22,23,24)/p+1/t9-,10+,11?,12?/m1/s1
  • InChiKey: QHMFEMKJMHEXGU-QKEWWQLBSA-O  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Heterochromatin protein 1 0.0078 0.0729 0.2459
Leishmania major beta tubulin 0.028 0.2964 1
Echinococcus multilocularis tubulin subunit TubB 0.0224 0.2344 0.2344
Onchocerca volvulus Huntingtin homolog 0.0118 0.1171 1
Echinococcus granulosus tubulin alpha 0.0157 0.1597 0.5057
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0077 0.0261
Schistosoma mansoni chromobox protein 0.0078 0.0729 0.2307
Loa Loa (eye worm) tubulin alpha-2 chain 0.0224 0.2344 0.742
Echinococcus multilocularis beta tubulin 0.028 0.2964 0.2964
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.0085 0.0287
Schistosoma mansoni hypothetical protein 0.0034 0.0234 0.0742
Leishmania major beta tubulin 0.028 0.2964 1
Schistosoma mansoni tubulin subunit beta 0.0068 0.0613 0.194
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.0085 0.0287
Echinococcus multilocularis hypothetical protein 0.0224 0.2344 0.2344
Trichomonas vaginalis tubulin beta chain, putative 0.0224 0.2344 0.7908
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0085 0.0269
Schistosoma mansoni tubulin subunit beta 0.028 0.2964 0.9382
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0077 0.0231
Trichomonas vaginalis tubulin epsilon chain, putative 0.0224 0.2344 0.7908
Echinococcus multilocularis tubulin alpha 1C chain 0.0224 0.2344 0.2344
Schistosoma mansoni hypothetical protein 0.0172 0.1766 0.559
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0077 0.0143
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0034 0.0234 0.0742
Schistosoma mansoni alpha tubulin 0.0224 0.2344 0.742
Leishmania major beta tubulin 0.028 0.2964 1
Echinococcus multilocularis Tubulin beta 2C chain 0.028 0.2964 0.2964
Trypanosoma brucei alpha tubulin 0.0224 0.2344 0.7902
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0077 0.0231
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0077 0.0231
Entamoeba histolytica tubulin alpha chain, putative 0.0224 0.2344 0.7908
Trypanosoma brucei tubulin gamma chain 0.0157 0.1597 0.5375
Brugia malayi Latrophilin receptor protein 2 0.0034 0.0234 0.0791
Brugia malayi chromobox protein homolog 3 0.0044 0.0346 0.1167
Trichomonas vaginalis tubulin beta chain, putative 0.028 0.2964 1
Echinococcus granulosus Tubulin beta 2C chain 0.028 0.2964 0.9382
Leishmania major beta tubulin 0.028 0.2964 1
Trichomonas vaginalis tubulin beta chain, putative 0.0224 0.2344 0.7908
Brugia malayi tubulin alpha chain - mouse 0.0224 0.2344 0.7908
Trypanosoma brucei epsilon tubulin 0.0157 0.1597 0.5375
Brugia malayi Tubulin alpha chain 0.0068 0.0613 0.2068
Leishmania major alpha tubulin 0.0224 0.2344 0.7883
Loa Loa (eye worm) tubulin beta chain 0.0068 0.0613 0.194
Loa Loa (eye worm) hypothetical protein 0.0118 0.1171 0.3708
Trichomonas vaginalis chromobox protein, putative 0.0078 0.0729 0.2459
Echinococcus granulosus GPCR family 2 0.0034 0.0234 0.0742
Trichomonas vaginalis tubulin beta chain, putative 0.0224 0.2344 0.7908
Trichomonas vaginalis tubulin epsilon chain, putative 0.0068 0.0613 0.2068
Leishmania major GTP-binding protein, putative 0.0021 0.0085 0.017
Trypanosoma brucei tubulin delta chain 0.0068 0.0613 0.2044
Echinococcus granulosus alpha tubulin 0.0224 0.2344 0.742
Echinococcus multilocularis tubulin alpha chain 0.0224 0.2344 0.2344
Trichomonas vaginalis chromobox protein, putative 0.0047 0.0383 0.1292
Schistosoma mansoni tubulin subunit beta 0.028 0.2964 0.9382
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.002 0.0077 0.0245
Loa Loa (eye worm) tubulin beta chain 0.028 0.2964 0.9382
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0035 0.0119
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.0375 0.1264
Trichomonas vaginalis tubulin, putative 0.0068 0.0613 0.2068
Leishmania major beta tubulin 0.028 0.2964 1
Leishmania major alpha tubulin 0.0224 0.2344 0.7883
Echinococcus multilocularis tubulin alpha chain 0.0224 0.2344 0.2344
Giardia lamblia Beta tubulin 0.028 0.2964 1
Trypanosoma cruzi alpha tubulin, putative 0.0224 0.2344 0.7883
Leishmania major alpha tubulin 0.0224 0.2344 0.7883
Echinococcus multilocularis Tubulin beta 2C chain 0.028 0.2964 0.2964
Brugia malayi hypothetical protein 0.0228 0.2394 0.8076
Echinococcus granulosus Tubulin alpha 1 chain 0.0224 0.2344 0.742
Echinococcus multilocularis beta tubulin 0.028 0.2964 0.2964
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0044 0.0346 0.2953
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0035 0.0035
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0016 0.0035 0.0119
Loa Loa (eye worm) hypothetical protein 0.0107 0.1049 0.3321
Toxoplasma gondii aldehyde dehydrogenase 0.0059 0.0509 0.1716
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0085 0.0287
Mycobacterium ulcerans cell division protein FtsZ 0.0068 0.0613 1
Echinococcus granulosus tubulin alpha 3 chain 0.0224 0.2344 0.742
Echinococcus multilocularis geminin 0.0172 0.1766 0.1766
Onchocerca volvulus 0.0047 0.0375 0.3199
Brugia malayi Cell division protein ftsZ 0.0068 0.0613 0.2068
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0041 0.0307 0.0307
Toxoplasma gondii beta-1 tubulin, putative 0.028 0.2964 1
Trichomonas vaginalis tubulin beta chain, putative 0.0224 0.2344 0.7908
Schistosoma mansoni alpha tubulin 0.0224 0.2344 0.742
Loa Loa (eye worm) hypothetical protein 0.002 0.0077 0.0245
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0077 0.0231
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.0085 0.0027
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0077 0.0231
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0167 0.0533
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0077 0.0231
Schistosoma mansoni hypothetical protein 0.0073 0.0672 0.2127
Plasmodium falciparum tubulin beta chain 0.028 0.2964 1
Giardia lamblia Gamma tubulin 0.0157 0.1597 0.5266
Entamoeba histolytica deoxycytidyl transferase, putative 0.002 0.0077 0.0261
Toxoplasma gondii HEAT repeat-containing protein 0.0028 0.0167 0.0562
Echinococcus granulosus tubulin alpha chain 0.0224 0.2344 0.742
Brugia malayi RNA, U transporter 1 0.0079 0.0737 0.2486
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0077 0.0231
Echinococcus multilocularis GPCR, family 2 0.0034 0.0234 0.0234
Brugia malayi hypothetical protein 0.0041 0.0307 0.1037
Echinococcus granulosus tubulin alpha 1C chain 0.0224 0.2344 0.742
Leishmania major alpha tubulin 0.0224 0.2344 0.7883
Trypanosoma brucei alpha tubulin 0.0224 0.2344 0.7902
Schistosoma mansoni ran 0.0021 0.0085 0.0269
Leishmania major beta tubulin 0.028 0.2964 1
Echinococcus granulosus tubulin alpha chain 0.0224 0.2344 0.742
Echinococcus multilocularis tubulin alpha 0.0157 0.1597 0.1597
Echinococcus granulosus tubulin beta 1 chain 0.028 0.2964 0.9382
Onchocerca volvulus Huntingtin homolog 0.0118 0.1171 1
Echinococcus multilocularis dna polymerase kappa 0.002 0.0077 0.0077
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0016 0.0035 0.0112
Schistosoma mansoni hypothetical protein 0.0297 0.3159 1
Giardia lamblia Epsilon tubulin 0.0068 0.0613 0.1855
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0034 0.0234 0.0791
Trypanosoma cruzi epsilon tubulin, putative 0.0157 0.1597 0.5334
Echinococcus granulosus beta tubulin 0.028 0.2964 0.9382
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0047 0.0383 0.3269
Schistosoma mansoni tubulin subunit epsilon 0.0157 0.1597 0.5057
Schistosoma mansoni tubulin subunit delta 0.0068 0.0613 0.194
Schistosoma mansoni terminal deoxycytidyl transferase 0.002 0.0077 0.0245
Loa Loa (eye worm) hypothetical protein 0.0044 0.0346 0.1095
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0077 0.0143
Schistosoma mansoni tubulin subunit beta 0.028 0.2964 0.9382
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0016 0.0035 0.0089
Entamoeba histolytica hypothetical protein 0.0041 0.0307 0.1037
Schistosoma mansoni ran 0.0021 0.0085 0.0269
Leishmania major alpha tubulin 0.0224 0.2344 0.7883
Loa Loa (eye worm) BEN-1 protein 0.028 0.2964 0.9382
Leishmania major beta tubulin 0.028 0.2964 1
Leishmania major alpha tubulin 0.0224 0.2344 0.7883
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0077 0.0231
Leishmania major epsilon tubulin, putative 0.0157 0.1597 0.5334
Echinococcus multilocularis Tubulin beta 2C chain 0.028 0.2964 0.2964
Echinococcus multilocularis chromobox protein 1 0.0078 0.0729 0.0729
Echinococcus multilocularis tubulin beta 1 chain 0.028 0.2964 0.2964
Echinococcus multilocularis tubulin subunit beta 0.028 0.2964 0.2964
Trichomonas vaginalis tubulin beta chain, putative 0.0224 0.2344 0.7908
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0085 0.0269
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0059 0.0509 0.0509
Loa Loa (eye worm) hypothetical protein 0.0028 0.0167 0.0528
Schistosoma mansoni tubulin subunit beta 0.028 0.2964 0.9382
Trypanosoma brucei zeta tubulin, putative 0.0068 0.0613 0.2044
Echinococcus multilocularis survival motor neuron protein 1 0.0228 0.2394 0.2394
Brugia malayi Tubulin alpha-2 chain 0.0224 0.2344 0.7908
Brugia malayi Tubulin alpha-2 chain 0.0224 0.2344 0.7908
Leishmania major importin beta-1 subunit, putative 0.0023 0.0108 0.0249
Echinococcus granulosus tubulin beta 4A class IVa 0.028 0.2964 0.9382
Echinococcus granulosus dna polymerase eta 0.002 0.0077 0.0245
Echinococcus multilocularis tubulin alpha 3 chain 0.0224 0.2344 0.2344
Brugia malayi Tubulin alpha chain 0.0224 0.2344 0.7908
Schistosoma mansoni hypothetical protein 0.0041 0.0307 0.0973
Echinococcus granulosus Tubulin alpha 1 chain 0.0224 0.2344 0.742
Onchocerca volvulus 0.0034 0.024 0.2052
Plasmodium falciparum tubulin gamma chain 0.0157 0.1597 0.539
Leishmania major alpha tubulin 0.0224 0.2344 0.7883
Loa Loa (eye worm) tubulin alpha chain 0.0224 0.2344 0.742
Schistosoma mansoni hypothetical protein 0.0034 0.0234 0.0742
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0224 0.2344 0.7908
Trypanosoma brucei beta tubulin 0.028 0.2964 1
Toxoplasma gondii beta tubulin 0.028 0.2964 1
Loa Loa (eye worm) tubulin beta-4 chain 0.028 0.2964 0.9382
Loa Loa (eye worm) alpha-tubulin 0.0224 0.2344 0.742
Trichomonas vaginalis tubulin alpha chain, putative 0.0089 0.0842 0.2841
Echinococcus multilocularis Tubulin alpha 1 chain 0.0224 0.2344 0.2344
Giardia lamblia Alpha-tubulin 0.0224 0.2344 0.7852
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0034 0.0234 0.0234
Echinococcus granulosus tubulin subunit TubB 0.0224 0.2344 0.742
Echinococcus granulosus tubulin subunit beta 0.028 0.2964 0.9382
Loa Loa (eye worm) tubulin beta-1 chain 0.028 0.2964 0.9382
Loa Loa (eye worm) hypothetical protein 0.0073 0.0672 0.2127
Echinococcus multilocularis dna polymerase eta 0.002 0.0077 0.0077
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0077 0.0231
Trichomonas vaginalis tubulin, putative 0.0089 0.0842 0.2841
Schistosoma mansoni hypothetical protein 0.0034 0.0234 0.0742
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0.0035 0.0112
Echinococcus granulosus snurportin 1 0.0297 0.3159 1
Trypanosoma brucei beta tubulin 0.0157 0.1597 0.5375
Treponema pallidum cell division protein FtsZ 0.0068 0.0613 0.5
Loa Loa (eye worm) tubulin alpha-3 chain 0.0135 0.1359 0.4303
Trypanosoma cruzi tubulin delta chain 0.0068 0.0613 0.1972
Entamoeba histolytica Ran family GTPase 0.0021 0.0085 0.0287
Leishmania major alpha tubulin 0.0224 0.2344 0.7883
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0035 0.0089
Echinococcus multilocularis Tubulin beta 2C chain 0.028 0.2964 0.2964
Trichomonas vaginalis conserved hypothetical protein 0.0068 0.0613 0.2068
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0035 0.0035
Leishmania major alpha tubulin 0.0224 0.2344 0.7883
Loa Loa (eye worm) tubulin alpha 2 0.0156 0.1588 0.5028
Echinococcus multilocularis tubulin gamma 1 chain 0.0157 0.1597 0.1597
Trypanosoma brucei beta tubulin 0.028 0.2964 1
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0068 0.0613 0.2068
Echinococcus granulosus tubulin delta chain 0.0068 0.0613 0.194
Loa Loa (eye worm) hypothetical protein 0.0224 0.2344 0.742
Trichomonas vaginalis tubulin alpha chain, putative 0.0089 0.0842 0.2841
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0089 0.0842 0.2841
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.002 0.0077 0.0245
Schistosoma mansoni tubulin subunit alpha 0.0224 0.2344 0.742
Leishmania major beta tubulin 0.028 0.2964 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0107 0.1049 0.3539
Loa Loa (eye worm) hypothetical protein 0.0156 0.1588 0.5028
Leishmania major beta tubulin 0.028 0.2964 1
Brugia malayi hypothetical protein 0.0118 0.1171 0.3952
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0035 0.0119
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0.0035 0.0112
Schistosoma mansoni transcription factor LCR-F1 0.0041 0.0307 0.0973
Schistosoma mansoni alpha tubulin 0.0224 0.2344 0.742
Trypanosoma brucei alpha tubulin 0.0224 0.2344 0.7902
Echinococcus granulosus importin subunit beta 1 0.0028 0.0167 0.0528
Plasmodium falciparum importin beta, putative 0.0028 0.0167 0.0562
Leishmania major beta tubulin 0.028 0.2964 1
Plasmodium falciparum tubulin delta chain, putative 0.0068 0.0613 0.2068
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0108 0.0365
Loa Loa (eye worm) heterochromatin protein 1 0.0078 0.0729 0.2307
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0059 0.0509 0.1616
Plasmodium vivax tubulin gamma chain, putative 0.0157 0.1597 0.539
Brugia malayi Calcitonin receptor-like protein seb-1 0.0107 0.1049 0.3539
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0108 0.0365
Loa Loa (eye worm) tubulin gamma chain 0.0157 0.1597 0.5057
Echinococcus multilocularis Tubulin beta 2C chain 0.028 0.2964 0.2964
Trypanosoma brucei alpha tubulin, putative 0.0089 0.0842 0.2819
Trichomonas vaginalis tubulin gamma chain, putative 0.028 0.2964 1
Onchocerca volvulus 0.0089 0.0842 0.7187
Entamoeba histolytica hypothetical protein 0.0041 0.0307 0.1037
Loa Loa (eye worm) alpha-tubulin 0.0224 0.2344 0.742
Trypanosoma brucei alpha tubulin 0.0224 0.2344 0.7902
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.002 0.0077 0.0245
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0077 0.0231
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0077 0.0231
Loa Loa (eye worm) tubulin alpha 2 0.0156 0.1588 0.5028
Echinococcus granulosus peroxisome assembly protein 26 0.0224 0.2344 0.742
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0157 0.1597 0.539
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0035 0.0035
Plasmodium vivax tubulin beta chain, putative 0.028 0.2964 1
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0068 0.0613 0.2068
Toxoplasma gondii alpha-tubulin I, putative 0.0224 0.2344 0.7908
Brugia malayi Isocitrate dehydrogenase 0.0016 0.0035 0.0119
Plasmodium falciparum alpha tubulin 2 0.0224 0.2344 0.7908
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0034 0.0234 0.0742
Trypanosoma cruzi beta tubulin, putative 0.028 0.2964 1
Echinococcus multilocularis importin subunit beta 1 0.0028 0.0167 0.0167
Schistosoma mansoni tubulin subunit alpha 0.0224 0.2344 0.742
Schistosoma mansoni tubulin subunit beta 0.028 0.2964 0.9382
Toxoplasma gondii beta-tubulin, putative 0.028 0.2964 1
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0156 0.1588 0.5359
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0034 0.0234 0.0234
Schistosoma mansoni tubulin subunit alpha 0.0224 0.2344 0.742
Trypanosoma brucei unspecified product 0.002 0.0077 0.0231
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.0085 0.0287
Loa Loa (eye worm) hypothetical protein 0.0135 0.1359 0.4303
Loa Loa (eye worm) tubulin alpha 2 0.0067 0.0604 0.1912
Echinococcus granulosus Tubulin beta 2C chain 0.028 0.2964 0.9382
Loa Loa (eye worm) BEN-1 protein 0.028 0.2964 0.9382
Echinococcus granulosus Tubulin alpha 1 chain 0.0224 0.2344 0.742
Trichomonas vaginalis tubulin gamma chain, putative 0.0068 0.0613 0.2068
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0059 0.0509 0.161
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0077 0.0231
Leishmania major beta tubulin 0.028 0.2964 1
Plasmodium falciparum alpha tubulin 1 0.0224 0.2344 0.7908
Mycobacterium leprae cell division protein FtsZ 0.0068 0.0613 0.5
Echinococcus granulosus tubulin alpha chain 0.0224 0.2344 0.742
Schistosoma mansoni importin beta-1 0.0028 0.0167 0.0528
Plasmodium falciparum tubulin epsilon chain, putative 0.0157 0.1597 0.539
Brugia malayi Tubulin gamma chain 0.0157 0.1597 0.539
Trichomonas vaginalis tubulin gamma chain, putative 0.0157 0.1597 0.539
Plasmodium vivax tubulin alpha chain, putative 0.0224 0.2344 0.7908
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0108 0.0365
Mycobacterium tuberculosis Conserved hypothetical protein 0.002 0.0077 0.0727
Entamoeba histolytica hypothetical protein 0.0041 0.0307 0.1037
Schistosoma mansoni chromobox protein 0.0078 0.0729 0.2307
Giardia lamblia Beta tubulin 0.028 0.2964 1
Brugia malayi Importin beta-1 subunit 0.0028 0.0167 0.0562
Echinococcus granulosus tubulin alpha 1C chain 0.0224 0.2344 0.742
Trichomonas vaginalis chromobox protein, putative 0.0078 0.0729 0.2459
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.002 0.0077 0.0077
Entamoeba histolytica hypothetical protein 0.0023 0.0108 0.0365
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0085 0.017
Echinococcus granulosus chromobox protein 1 0.0078 0.0729 0.2307
Trichomonas vaginalis ran, putative 0.0021 0.0085 0.0287
Echinococcus granulosus tubulin alpha 3 chain 0.0224 0.2344 0.742
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.0085 0.0257
Echinococcus multilocularis muscleblind protein 0.0168 0.1726 0.1726
Echinococcus multilocularis tubulin alpha chain 0.0224 0.2344 0.2344
Plasmodium vivax delta tubulin, putative 0.0068 0.0613 0.2068
Trichomonas vaginalis tubulin beta-1 chain, putative 0.0068 0.0613 0.2068
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0509 0.8054
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.002 0.0077 0.0143
Wolbachia endosymbiont of Brugia malayi cell division protein FtsZ 0.0068 0.0613 0.5
Echinococcus multilocularis tubulin alpha 1C chain 0.0224 0.2344 0.2344
Leishmania major alpha tubulin 0.0224 0.2344 0.7883
Loa Loa (eye worm) hypothetical protein 0.0118 0.1171 0.3708
Leishmania major alpha tubulin 0.0224 0.2344 0.7883
Trypanosoma brucei DNA polymerase eta, putative 0.002 0.0077 0.0231
Echinococcus multilocularis Tubulin alpha 1 chain 0.0224 0.2344 0.2344
Entamoeba histolytica tubulin alpha-1 chain 0.0224 0.2344 0.7908
Leishmania major beta tubulin 0.028 0.2964 1
Loa Loa (eye worm) hypothetical protein 0.0168 0.1726 0.5463
Leishmania major beta tubulin 0.028 0.2964 1
Echinococcus multilocularis snurportin 1 0.0297 0.3159 0.3159
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0203 0.0686
Giardia lamblia Beta tubulin 0.028 0.2964 1
Trypanosoma cruzi tubulin gamma chain 0.0157 0.1597 0.5334
Plasmodium vivax importin-beta 2, putative 0.0028 0.0167 0.0562
Echinococcus multilocularis muscleblind protein 1 0.0168 0.1726 0.1726
Echinococcus granulosus tubulin epsilon chain 0.0157 0.1597 0.5057
Schistosoma mansoni hypothetical protein 0.0047 0.0375 0.1186
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0077 0.0143
Schistosoma mansoni tubulin subunit alpha 0.0068 0.0613 0.194
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0059 0.0509 0.8195
Trypanosoma brucei epsilon tubulin 0.0157 0.1597 0.5375
Trichomonas vaginalis tubulin epsilon chain, putative 0.028 0.2964 1
Brugia malayi isocitrate dehydrogenase 0.0016 0.0035 0.0119
Echinococcus multilocularis Tubulin alpha 1 chain 0.0224 0.2344 0.2344
Echinococcus granulosus Tubulin beta 2C chain 0.028 0.2964 0.9382
Schistosoma mansoni hypothetical protein 0.0034 0.0234 0.0742
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0077 0.0231
Loa Loa (eye worm) alpha-tubulin isotype 2 0.0156 0.1588 0.5028
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0203 0.0686
Echinococcus granulosus dna polymerase kappa 0.002 0.0077 0.0245
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0077 0.0261
Brugia malayi tubulin alpha-2 chain 0.0224 0.2344 0.7908
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0346 0.1167
Entamoeba histolytica tubulin family protein 0.028 0.2964 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0034 0.0234 0.0742
Entamoeba histolytica tubulin family protein 0.028 0.2964 1
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0085 0.0085
Loa Loa (eye worm) hypothetical protein 0.0034 0.024 0.0761
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0509 0.161
Echinococcus granulosus Tubulin beta 2C chain 0.028 0.2964 0.9382
Echinococcus granulosus survival motor neuron protein 1 0.0228 0.2394 0.7577
Trichomonas vaginalis tubulin beta chain, putative 0.0089 0.0842 0.2841
Leishmania major beta tubulin 0.028 0.2964 1
Echinococcus granulosus Tubulin beta 2C chain 0.028 0.2964 0.9382
Entamoeba histolytica hypothetical protein 0.0041 0.0307 0.1037
Schistosoma mansoni DNA polymerase eta 0.002 0.0077 0.0245
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0346 0.1167
Loa Loa (eye worm) tubulin alpha chain 0.0224 0.2344 0.742
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0108 0.0249
Brugia malayi Tubulin beta chain 0.0068 0.0613 0.2068
Echinococcus multilocularis peroxisome assembly protein 26 0.0224 0.2344 0.2344
Entamoeba histolytica tubulin gamma chain 0.0157 0.1597 0.539
Leishmania major beta tubulin 0.028 0.2964 1
Loa Loa (eye worm) beta-tubulin 0.028 0.2964 0.9382
Trichomonas vaginalis chromobox protein, putative 0.0047 0.0383 0.1292
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0135 0.1359 0.4586
Brugia malayi beta-tubulin, identical 0.028 0.2964 1
Brugia malayi Tubulin beta-1 chain 0.028 0.2964 1
Trypanosoma brucei zeta tubulin 0.0068 0.0613 0.2044
Trichomonas vaginalis tubulin epsilon chain, putative 0.028 0.2964 1
Leishmania major beta tubulin 0.028 0.2964 1
Brugia malayi alpha-tubulin 0.0224 0.2344 0.7908
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0509 0.8054
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.002 0.0077 0.0727
Schistosoma mansoni hypothetical protein 0.0172 0.1766 0.559
Plasmodium vivax tubulin epsilon chain, putative 0.0157 0.1597 0.539
Giardia lamblia Delta tubulin 0.0068 0.0613 0.1855
Schistosoma mansoni tubulin subunit gamma 0.0157 0.1597 0.5057
Echinococcus multilocularis chromobox protein 1 0.0078 0.0729 0.0729
Trypanosoma brucei beta tubulin 0.028 0.2964 1
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0085 0.017
Echinococcus granulosus tubulin gamma 1 chain 0.0157 0.1597 0.5057
Trypanosoma brucei beta tubulin 0.028 0.2964 1
Leishmania major DNA polymerase eta, putative 0.002 0.0077 0.0143
Loa Loa (eye worm) hypothetical protein 0.0168 0.1726 0.5463
Trypanosoma brucei epsilon tubulin 0.0157 0.1597 0.5375
Giardia lamblia Alpha-tubulin 0.0224 0.2344 0.7852
Trichomonas vaginalis conserved hypothetical protein 0.0068 0.0613 0.2068
Brugia malayi Tubulin beta chain 0.0089 0.0842 0.2841
Trichomonas vaginalis tubulin gamma chain, putative 0.0157 0.1597 0.539
Echinococcus multilocularis tubulin epsilon chain 0.0157 0.1597 0.1597
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0297 0.3159 1
Echinococcus multilocularis tubulin alpha 3 chain 0.0224 0.2344 0.2344
Schistosoma mansoni tubulin subunit beta 0.028 0.2964 0.9382
Trichomonas vaginalis DNA polymerase eta, putative 0.002 0.0077 0.0261
Loa Loa (eye worm) hypothetical protein 0.0228 0.2394 0.7577
Leishmania major DNA polymerase kappa, putative 0.002 0.0077 0.0143
Leishmania major zeta tubulin, putative 0.0068 0.0613 0.1972
Echinococcus multilocularis tubulin delta chain 0.0068 0.0613 0.0613
Trypanosoma cruzi zeta tubulin, putative 0.0068 0.0613 0.1972
Echinococcus granulosus chromobox protein 1 0.0078 0.0729 0.2307
Trichomonas vaginalis tubulin alpha chain, putative 0.0157 0.1597 0.539
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0016 0.0035 0.0119
Echinococcus multilocularis tubulin, beta 4A class IVa 0.028 0.2964 0.2964
Echinococcus granulosus beta tubulin 0.028 0.2964 0.9382
Trichomonas vaginalis tubulin beta chain, putative 0.0224 0.2344 0.7908
Echinococcus multilocularis tubulin alpha chain 0.0224 0.2344 0.2344
Leishmania major gamma-tubulin 0.0157 0.1597 0.5334
Echinococcus granulosus tubulin alpha chain 0.0224 0.2344 0.742
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0077 0.0143
Brugia malayi Muscleblind-like protein 0.0168 0.1726 0.5823
Leishmania major beta tubulin 0.028 0.2964 1
Trichomonas vaginalis tubulin, putative 0.028 0.2964 1
Trichomonas vaginalis tubulin, putative 0.0089 0.0842 0.2841
Brugia malayi latrophilin 2 splice variant baaae 0.0073 0.0672 0.2267
Loa Loa (eye worm) tubulin beta-2A chain 0.028 0.2964 0.9382
Echinococcus granulosus muscleblind protein 0.0168 0.1726 0.5463
Schistosoma mansoni survival motor neuron protein 0.0047 0.0375 0.1186
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.002 0.0077 0.0261
Trypanosoma cruzi DNA polymerase eta, putative 0.002 0.0077 0.0143
Echinococcus multilocularis isocitrate dehydrogenase 0.0016 0.0035 0.0035
Trypanosoma cruzi zeta tubulin, putative 0.0068 0.0613 0.1972
Leishmania major alpha tubulin 0.0224 0.2344 0.7883
Echinococcus granulosus tubulin alpha chain 0.0224 0.2344 0.742
Toxoplasma gondii alpha tubulin TUBA1 0.0224 0.2344 0.7908
Trichomonas vaginalis tubulin epsilon chain, putative 0.0224 0.2344 0.7908
Leishmania major beta tubulin 0.028 0.2964 1
Trichomonas vaginalis tubulin alpha chain, putative 0.028 0.2964 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0509 0.8054
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0016 0.0035 0.0035
Plasmodium vivax tubulin alpha chain, putative 0.0224 0.2344 0.7908
Echinococcus granulosus geminin 0.0172 0.1766 0.559
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0041 0.0307 0.0973
Trichomonas vaginalis tubulin alpha chain, putative 0.0089 0.0842 0.2841
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0107 0.1049 0.3321
Echinococcus multilocularis tubulin alpha chain 0.0224 0.2344 0.2344
Trypanosoma cruzi epsilon tubulin, putative 0.0157 0.1597 0.5334
Leishmania major delta tubulin, putative 0.0068 0.0613 0.1972
Loa Loa (eye worm) hypothetical protein 0.0034 0.0234 0.0742
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0509 0.161
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0167 0.0533
Mycobacterium tuberculosis Cell division protein FtsZ 0.0068 0.0613 1
Trypanosoma cruzi tubulin delta chain 0.0068 0.0613 0.1972

Activities

Activity type Activity value Assay description Source Reference
RRT (functional) = 38.4 s Time of recovery of righting reflux (RRT) in seconds was measured after administration of 300 mg/kg intravenously in mice for the promotional effect on recovery from coma ChEMBL. 1676756
SMT (functional) = 47.5 s Time of recovery of spontaneous movement (SMT) in seconds was measured after administration of 300 mg/kg intravenously in mice for the promotional effect on recovery from coma ChEMBL. 1676756
SVT (functional) 0 Antihypoxic effect of the compound was tested by the survival time (SVT) in mice at a dose of 100 mg/kg administered orally in mice; NT indicates not tested ChEMBL. 1676756
SVT (functional) = 88.8 Antihypoxic effect of the compound was tested by the survival time (SVT) in mice at a dose of 300 mg/kg administered intravenously in mice ChEMBL. 1676756

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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