TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 256.755 | Formula: C10H13ClN4S
H donors: 2 H acceptors: 2 LogP: 3.13 Rotable bonds: 2
Rule of 5 violations (Lipinski): 1
SMILES: NNc1nnc(s1)c1cccc(c1C)C.Cl
InChi: 1S/C10H12N4S.ClH/c1-6-4-3-5-8(7(6)2)9-13-14-10(12-11)15-9;/h3-5H,11H2,1-2H3,(H,12,14);1H
InChiKey: DNWZNNBCFVHEKV-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Onchocerca volvulus		0.02	0.2558	0.2605
Loa Loa (eye worm)	hypothetical protein	0.0027	0.007	0.0062
Loa Loa (eye worm)	blistered cuticle protein 3	0.0621	0.8575	1
Loa Loa (eye worm)	hypothetical protein	0.0621	0.8575	1
Echinococcus multilocularis	neurogenic locus protein delta	0.02	0.2558	0.2558
Brugia malayi	RNA recognition motif domain containing protein	0.0071	0.0702	0.0743
Schistosoma mansoni	tar DNA-binding protein	0.0071	0.0702	0.0702
Loa Loa (eye worm)	hypothetical protein	0.0074	0.075	0.0857
Onchocerca volvulus		0.02	0.2558	0.2605
Schistosoma mansoni	notch	0.02	0.2558	0.2558
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0054	0.0459	0.0458
Trypanosoma brucei	hypothetical protein, conserved	0.0074	0.075	1
Echinococcus granulosus	slit 2 protein	0.02	0.2558	0.2558
Schistosoma mansoni	hypothetical protein	0.0023	0.0017	0.0017
Toxoplasma gondii	ABC1 family protein	0.0074	0.075	0.2735
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0038	0.0234	0.0234
Schistosoma mansoni	notch	0.02	0.2558	0.2558
Loa Loa (eye worm)	beta-lactamase	0.0074	0.075	0.0857
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0074	0.075	0.075
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0092	0.0999	0.1185
Mycobacterium ulcerans	fructose-bisphosphate aldolase	0.014	0.1693	0.3393
Loa Loa (eye worm)	notch protein	0.02	0.2558	0.2969
Onchocerca volvulus		0.0074	0.075	0.0383
Schistosoma mansoni	notch	0.02	0.2558	0.2558
Loa Loa (eye worm)	hypothetical protein	0.02	0.2558	0.2969
Onchocerca volvulus	Chorion peroxidase homolog	0.0621	0.8575	1
Loa Loa (eye worm)	hypothetical protein	0.0621	0.8575	1
Loa Loa (eye worm)	animal heme peroxidase	0.0621	0.8575	1
Onchocerca volvulus	Peroxidase homolog	0.0621	0.8575	1
Brugia malayi	TAR-binding protein	0.0071	0.0702	0.0743
Echinococcus granulosus	protein jagged 1	0.02	0.2558	0.2558
Echinococcus multilocularis	neurogenic locus notch protein	0.02	0.2558	0.2558
Schistosoma mansoni	peroxidasin	0.0621	0.8575	0.8575
Mycobacterium leprae	Probable fructose bisphosphate aldolase Fba	0.014	0.1693	1
Onchocerca volvulus		0.0074	0.075	0.0383
Treponema pallidum	fructose-bisphosphate aldolase	0.0287	0.3794	0.5
Loa Loa (eye worm)	hypothetical protein	0.0074	0.075	0.0857
Echinococcus multilocularis	neurogenic locus protein delta	0.02	0.2558	0.2558
Brugia malayi	Bromodomain containing protein	0.0084	0.0888	0.0963
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0074	0.075	0.0785
Loa Loa (eye worm)	hypothetical protein	0.02	0.2558	0.2969
Onchocerca volvulus	Dual oxidase homolog	0.0621	0.8575	1
Echinococcus multilocularis	notch	0.02	0.2558	0.2558
Loa Loa (eye worm)	hypothetical protein	0.02	0.2558	0.2969
Loa Loa (eye worm)	hypothetical protein	0.02	0.2558	0.2969
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0287	0.3794	1
Loa Loa (eye worm)	glutaminase 2	0.0268	0.3529	0.4103
Brugia malayi	PHD-finger family protein	0.0028	0.0086	0.0019
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0074	0.075	0.075
Loa Loa (eye worm)	hypothetical protein	0.02	0.2558	0.2969
Loa Loa (eye worm)	animal heme peroxidase	0.0621	0.8575	1
Echinococcus multilocularis	peroxidasin	0.0621	0.8575	0.8575
Loa Loa (eye worm)	hypothetical protein	0.02	0.2558	0.2969
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0287	0.3794	1
Loa Loa (eye worm)	glutaminase	0.0268	0.3529	0.4103
Loa Loa (eye worm)	Notch2	0.02	0.2558	0.2969
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0067	0.0643	0.0643
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0102	0.1146	0.4196
Mycobacterium ulcerans	glutaminase	0.0268	0.3529	1
Brugia malayi	EGF-like domain containing protein	0.02	0.2558	0.2925
Loa Loa (eye worm)	hypothetical protein	0.02	0.2558	0.2969
Loa Loa (eye worm)	hypothetical protein	0.0621	0.8575	1
Onchocerca volvulus		0.0315	0.4203	0.4626
Loa Loa (eye worm)	thioredoxin reductase	0.004	0.0262	0.0286
Schistosoma mansoni	peroxidasin	0.0621	0.8575	0.8575
Brugia malayi	beta-lactamase family protein	0.0074	0.075	0.08
Schistosoma mansoni	hypothetical protein	0.02	0.2558	0.2558
Brugia malayi	hypothetical protein	0.0265	0.3477	0.4006
Onchocerca volvulus		0.0054	0.0459	0.0025
Echinococcus multilocularis	protein jagged 1	0.02	0.2558	0.2558
Brugia malayi	Muscle positioning protein 4	0.02	0.2558	0.2925
Brugia malayi	EGF-like domain containing protein	0.02	0.2558	0.2925
Echinococcus multilocularis	protein jagged 2	0.02	0.2558	0.2558
Loa Loa (eye worm)	hypothetical protein	0.02	0.2558	0.2969
Echinococcus granulosus	neurogenic locus protein delta	0.02	0.2558	0.2558
Loa Loa (eye worm)	hypothetical protein	0.0621	0.8575	1
Schistosoma mansoni	hypothetical protein	0.02	0.2558	0.2558
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0102	0.1146	0.1421
Echinococcus multilocularis	fat cadherin tumor suppressor	0.02	0.2558	0.2558
Onchocerca volvulus	Neurogenic locus notch protein homolog	0.02	0.2558	0.2605
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.004	0.0262	0.0262
Loa Loa (eye worm)	animal heme peroxidase	0.0621	0.8575	1
Loa Loa (eye worm)	hypothetical protein	0.02	0.2558	0.2969
Schistosoma mansoni	hypothetical protein	0.02	0.2558	0.2558
Schistosoma mansoni	acetyl-CoA C-acetyltransferase	0.0025	0.0048	0.0048
Brugia malayi	Bromodomain containing protein	0.0043	0.03	0.0271
Plasmodium falciparum	thioredoxin reductase	0.004	0.0262	1
Mycobacterium tuberculosis	Probable dehydrogenase	0.0092	0.0999	0.1185
Loa Loa (eye worm)	hypothetical protein	0.02	0.2558	0.2969
Schistosoma mansoni	glutaminase	0.0268	0.3529	0.3529
Schistosoma mansoni	tar DNA-binding protein	0.0071	0.0702	0.0702
Loa Loa (eye worm)	hypothetical protein	0.02	0.2558	0.2969
Echinococcus granulosus	tar DNA binding protein	0.0071	0.0702	0.0702
Schistosoma mansoni	laminin gamma-3 chain	0.02	0.2558	0.2558
Schistosoma mansoni	bromodomain containing protein	0.0071	0.0701	0.0701
Loa Loa (eye worm)	RNA binding protein	0.0071	0.0702	0.08
Schistosoma mansoni	Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)]	0.02	0.2558	0.2558
Brugia malayi	Cadherin domain containing protein	0.02	0.2558	0.2925
Leishmania major	hypothetical protein, conserved	0.0074	0.075	1
Loa Loa (eye worm)	hypothetical protein	0.02	0.2558	0.2969
Loa Loa (eye worm)	animal heme peroxidase	0.0621	0.8575	1
Loa Loa (eye worm)	hypothetical protein	0.0621	0.8575	1
Brugia malayi	Animal haem peroxidase family protein	0.0621	0.8575	1
Schistosoma mansoni	septate junction protein	0.02	0.2558	0.2558
Brugia malayi	hypothetical protein	0.0315	0.4203	0.486
Brugia malayi	beta-lactamase	0.0074	0.075	0.08
Echinococcus granulosus	neural cadherin	0.02	0.2558	0.2558
Loa Loa (eye worm)	hypothetical protein	0.02	0.2558	0.2969
Brugia malayi	Animal haem peroxidase family protein	0.0621	0.8575	1
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0339	0.0377
Echinococcus multilocularis	neurogenic locus notch protein 4	0.02	0.2558	0.2558
Brugia malayi	Delta serrate ligand family protein	0.02	0.2558	0.2925
Echinococcus multilocularis	fetal alzheimer antigen, falz	0.0025	0.0048	0.0048
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0038	0.0234	0.0234
Loa Loa (eye worm)	hypothetical protein	0.0074	0.075	0.0857
Schistosoma mansoni	hypothetical protein	0.02	0.2558	0.2558
Echinococcus multilocularis	microtubule associated protein 2	0.072	1	1
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0102	0.1146	0.1421
Echinococcus granulosus	peroxidasin	0.0621	0.8575	0.8575
Echinococcus granulosus	neurogenic locus notch protein	0.02	0.2558	0.2558
Onchocerca volvulus		0.0074	0.075	0.0383
Loa Loa (eye worm)	hypothetical protein	0.0621	0.8575	1
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0071	0.0702	0.08
Mycobacterium tuberculosis	Probable lipase LipD	0.0074	0.075	0.0785
Loa Loa (eye worm)	hypothetical protein	0.0621	0.8575	1
Echinococcus granulosus	protein jagged 1	0.02	0.2558	0.2558
Mycobacterium tuberculosis	Conserved protein	0.0074	0.075	0.0785
Echinococcus multilocularis	fibropellin Ia	0.02	0.2558	0.2558
Schistosoma mansoni	cell polarity protein	0.02	0.2558	0.2558
Brugia malayi	EGF-like domain containing protein	0.02	0.2558	0.2925
Loa Loa (eye worm)	hypothetical protein	0.0621	0.8575	1
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0074	0.075	0.0857
Onchocerca volvulus		0.0621	0.8575	1
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.0287	0.3794	1
Loa Loa (eye worm)	hypothetical protein	0.02	0.2558	0.2969
Trichomonas vaginalis	glutaminase, putative	0.0268	0.3529	0.9127
Echinococcus multilocularis	neurogenic locus notch protein	0.02	0.2558	0.2558
Onchocerca volvulus	Slit protein homolog	0.02	0.2558	0.2605
Schistosoma mansoni	tar DNA-binding protein	0.0071	0.0702	0.0702
Loa Loa (eye worm)	hypothetical protein	0.0315	0.4203	0.4891
Schistosoma mansoni	notch	0.02	0.2558	0.2558
Schistosoma mansoni	hypothetical protein	0.0177	0.2219	0.2219
Brugia malayi	Animal haem peroxidase family protein	0.0621	0.8575	1
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0287	0.3794	1
Brugia malayi	Calcium binding EGF domain containing protein	0.02	0.2558	0.2925
Loa Loa (eye worm)	hypothetical protein	0.0621	0.8575	1
Echinococcus granulosus	geminin	0.0177	0.2219	0.2219
Loa Loa (eye worm)	hypothetical protein	0.02	0.2558	0.2969
Loa Loa (eye worm)	glutathione reductase	0.004	0.0262	0.0286
Echinococcus granulosus	protein jagged 2	0.02	0.2558	0.2558
Onchocerca volvulus	Putative cubilin	0.02	0.2558	0.2605
Echinococcus multilocularis	geminin	0.0177	0.2219	0.2219
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0041	0.027	0.027
Schistosoma mansoni	hypothetical protein	0.0177	0.2219	0.2219
Loa Loa (eye worm)	hypothetical protein	0.02	0.2558	0.2969
Echinococcus granulosus	neurogenic locus notch protein 4	0.02	0.2558	0.2558
Giardia lamblia	Fructose-bisphosphate aldolase	0.0287	0.3794	1
Onchocerca volvulus	Peroxidasin homolog	0.0621	0.8575	1
Schistosoma mansoni	hypothetical protein	0.02	0.2558	0.2558
Brugia malayi	MH2 domain containing protein	0.0125	0.147	0.1647
Loa Loa (eye worm)	hypothetical protein	0.0074	0.075	0.0857
Loa Loa (eye worm)	hypothetical protein	0.02	0.2558	0.2969
Schistosoma mansoni	slit	0.02	0.2558	0.2558
Onchocerca volvulus	Peroxidase homolog	0.0621	0.8575	1
Brugia malayi	EGF-like domain containing protein	0.02	0.2558	0.2925
Loa Loa (eye worm)	hypothetical protein	0.0621	0.8575	1
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0074	0.075	0.0785
Loa Loa (eye worm)	hypothetical protein	0.0074	0.075	0.0857
Schistosoma mansoni	tar DNA-binding protein	0.0071	0.0702	0.0702
Echinococcus granulosus	survival motor neuron protein 1	0.0265	0.3477	0.3477
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0439	0.0493
Loa Loa (eye worm)	hypothetical protein	0.0048	0.037	0.0412
Onchocerca volvulus	Peroxidasin homolog	0.0621	0.8575	1
Echinococcus granulosus	fibropellin Ia	0.02	0.2558	0.2558
Onchocerca volvulus		0.0621	0.8575	1
Brugia malayi	Thioredoxin reductase	0.004	0.0262	0.0226
Onchocerca volvulus	Neurogenic locus notch homolog	0.02	0.2558	0.2605
Trypanosoma cruzi	trypanothione reductase, putative	0.004	0.0262	0.2822
Trypanosoma cruzi	hypothetical protein, conserved	0.0074	0.075	1
Schistosoma mansoni	cellular tumor antigen P53	0.0053	0.0439	0.0439
Brugia malayi	hypothetical protein	0.0038	0.0234	0.0193
Schistosoma mansoni	hypothetical protein	0.0054	0.0459	0.0459
Echinococcus granulosus	delta-like protein 1	0.02	0.2558	0.2558
Onchocerca volvulus		0.02	0.2558	0.2605
Brugia malayi	Peroxidasin	0.0621	0.8575	1
Echinococcus granulosus	protein jagged 2	0.02	0.2558	0.2558
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0092	0.0999	0.1185
Brugia malayi	glutaminase DH11.1	0.0268	0.3529	0.4066
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0301	0.0332
Mycobacterium tuberculosis	Probable hydrolase	0.0074	0.075	0.0785
Echinococcus multilocularis	survival motor neuron protein 1	0.0265	0.3477	0.3477
Loa Loa (eye worm)	hypothetical protein	0.0265	0.3477	0.4043
Brugia malayi	hypothetical protein	0.0621	0.8575	1
Brugia malayi	GCC2 and GCC3 family protein	0.02	0.2558	0.2925
Echinococcus granulosus	fetal alzheimer antigen falz	0.0025	0.0048	0.0048
Mycobacterium tuberculosis	Probable esterase LipL	0.0074	0.075	0.0785
Brugia malayi	EGF-like domain containing protein	0.02	0.2558	0.2925
Mycobacterium tuberculosis	Probable fructose-bisphosphate aldolase Fba	0.014	0.1693	0.23
Echinococcus granulosus	tumor protein p63	0.0359	0.4828	0.4828
Echinococcus granulosus	beta LACTamase domain containing family member	0.0074	0.075	0.075
Mycobacterium tuberculosis	Probable reductase	0.0092	0.0999	0.1185
Echinococcus granulosus	notch	0.02	0.2558	0.2558
Mycobacterium tuberculosis	Probable oxidoreductase	0.0102	0.1146	0.1421
Mycobacterium leprae	PROBABLE NADH DEHYDROGENASE NDH	0.0092	0.0999	0.2642
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0074	0.075	0.075
Echinococcus multilocularis	tumor protein p63	0.0359	0.4828	0.4828
Brugia malayi	Calcium binding EGF domain containing protein	0.02	0.2558	0.2925
Loa Loa (eye worm)	hypothetical protein	0.0621	0.8575	1
Mycobacterium tuberculosis	Conserved protein	0.0074	0.075	0.0785
Brugia malayi	Animal haem peroxidase family protein	0.0621	0.8575	1
Brugia malayi	glutathione reductase	0.004	0.0262	0.0226
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0092	0.0999	0.1185
Toxoplasma gondii	thioredoxin reductase	0.004	0.0262	0.0772
Brugia malayi	Blistered cuticle protein 3	0.0621	0.8575	1
Onchocerca volvulus		0.02	0.2558	0.2605
Loa Loa (eye worm)	TAR-binding protein	0.0071	0.0702	0.08
Schistosoma mansoni	transcription factor LCR-F1	0.0038	0.0234	0.0234
Brugia malayi	EGF-like domain containing protein	0.02	0.2558	0.2925
Brugia malayi	beta-lactamase family protein	0.0074	0.075	0.08
Brugia malayi	Animal haem peroxidase family protein	0.0621	0.8575	1
Schistosoma mansoni	survival motor neuron protein	0.0054	0.0459	0.0459
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0067	0.0643	0.0643
Loa Loa (eye worm)	transcription factor SMAD2	0.0125	0.147	0.1698
Brugia malayi	Cadherin domain containing protein	0.02	0.2558	0.2925
Plasmodium vivax	thioredoxin reductase, putative	0.004	0.0262	0.2822
Schistosoma mansoni	tar DNA-binding protein	0.0071	0.0702	0.0702
Loa Loa (eye worm)	MH2 domain-containing protein	0.0125	0.147	0.1698
Echinococcus multilocularis	neural cadherin	0.02	0.2558	0.2558
Schistosoma mansoni	hypothetical protein	0.02	0.2558	0.2558
Echinococcus multilocularis	slit 2 protein	0.02	0.2558	0.2558
Brugia malayi	EGF-like domain containing protein	0.02	0.2558	0.2925
Trypanosoma brucei	trypanothione reductase	0.004	0.0262	0.2822
Loa Loa (eye worm)	hypothetical protein	0.0079	0.082	0.0938
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0475	0.6485	1
Loa Loa (eye worm)	hypothetical protein	0.0621	0.8575	1
Onchocerca volvulus		0.02	0.2558	0.2605
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0074	0.075	0.0785
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0287	0.3794	1
Schistosoma mansoni	hypothetical protein	0.0038	0.0234	0.0234
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0074	0.075	0.08
Schistosoma mansoni	notch	0.02	0.2558	0.2558
Echinococcus multilocularis	protein jagged 1	0.02	0.2558	0.2558
Loa Loa (eye worm)	hypothetical protein	0.0621	0.8575	1
Schistosoma mansoni	microtubule-associated protein tau	0.072	1	1
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0287	0.3794	1
Brugia malayi	Calcium binding EGF domain containing protein	0.02	0.2558	0.2925
Toxoplasma gondii	EGF family domain-containing protein	0.02	0.2558	1
Brugia malayi	notch-like transmembrane receptor	0.02	0.2558	0.2925
Brugia malayi	Transmembrane cell adhesion receptor mua-3 precursor, putative	0.02	0.2558	0.2925
Loa Loa (eye worm)	hypothetical protein	0.02	0.2558	0.2969
Loa Loa (eye worm)	hypothetical protein	0.0074	0.075	0.0857
Loa Loa (eye worm)	hypothetical protein	0.02	0.2558	0.2969
Echinococcus granulosus	neurogenic locus notch protein	0.02	0.2558	0.2558
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0287	0.3794	1
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.004	0.0262	0.0262
Echinococcus multilocularis	tar DNA binding protein	0.0071	0.0702	0.0702
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0287	0.3794	1
Trypanosoma cruzi	hypothetical protein, conserved	0.0074	0.075	1
Leishmania major	trypanothione reductase	0.004	0.0262	0.2822
Schistosoma mansoni	notch	0.02	0.2558	0.2558
Loa Loa (eye worm)	hypothetical protein	0.02	0.2558	0.2969
Echinococcus granulosus	thioredoxin glutathione reductase	0.0041	0.027	0.027
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.0287	0.3794	1
Loa Loa (eye worm)	hypothetical protein	0.02	0.2558	0.2969
Loa Loa (eye worm)	hypothetical protein	0.02	0.2558	0.2969
Loa Loa (eye worm)	hypothetical protein	0.0621	0.8575	1
Brugia malayi	RNA binding protein	0.0071	0.0702	0.0743
Schistosoma mansoni	hypothetical protein	0.02	0.2558	0.2558
Plasmodium vivax	glutathione reductase, putative	0.004	0.0262	0.2822
Plasmodium vivax	hypothetical protein, conserved	0.0074	0.075	1
Mycobacterium tuberculosis	Conserved protein	0.0074	0.075	0.0785
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0287	0.3794	1
Plasmodium falciparum	glutathione reductase	0.004	0.0262	1
Onchocerca volvulus		0.0621	0.8575	1
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0092	0.0999	0.1185
Mycobacterium tuberculosis	Probable lipase LipE	0.0074	0.075	0.0785

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL535355

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1026164