TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 417.929 | Formula: C22H28ClN3O3
H donors: 2 H acceptors: 2 LogP: 4.94 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: O=C(Nc1c(C)cccc1C)Oc1ccc2c(c1)[C@]1(C)CC[N+]([C@@H]1N2C)([O-])C.Cl
InChi: 1S/C22H27N3O3.ClH/c1-14-7-6-8-15(2)19(14)23-21(26)28-16-9-10-18-17(13-16)22(3)11-12-25(5,27)20(22)24(18)4;/h6-10,13,20H,11-12H2,1-5H3,(H,23,26);1H/t20-,22-,25?;/m0./s1
InChiKey: VXGUMUCYPRASGK-QFPJJMDASA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Leishmania major	cathepsin L-like protease	0.0073	0.0244	0.1876
Schistosoma mansoni	importin beta-1	0.006	0.0178	0.0265
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0052	0.0142	0.0189
Trypanosoma brucei	DNA polymerase kappa, putative	0.004	0.0084	0.0648
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.014	0.0566	0.0842
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0101	0.038	0.0509
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0073	0.0244	0.1876
Leishmania major	cathepsin L-like protease	0.0073	0.0244	0.1876
Loa Loa (eye worm)	glutaminase 2	0.0264	0.1166	0.156
Echinococcus multilocularis	importin subunit beta 1	0.006	0.0178	0.0178
Schistosoma mansoni	hypothetical protein	0.0029	0.0028	0.0042
Schistosoma mansoni	smad1 5 8 and	0.0076	0.0259	0.0384
Brugia malayi	latrophilin 2 splice variant baaae	0.0246	0.1077	0.1441
Entamoeba histolytica	deoxycytidyl transferase, putative	0.004	0.0084	0.0644
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0124	0.049	0.0728
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0064	0.02	0.0297
Echinococcus granulosus	dna polymerase kappa	0.004	0.0084	0.0084
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.014	0.0566	0.0566
Schistosoma mansoni	lamin	0.0027	0.0021	0.0031
Echinococcus multilocularis	phosphatidylinositol 3 and 4 kinase	0.0066	0.0207	0.0207
Onchocerca volvulus		0.0306	0.137	0.2785
Loa Loa (eye worm)	hypothetical protein	0.01	0.0374	0.0501
Brugia malayi	Pre-SET motif family protein	0.0064	0.02	0.0268
Brugia malayi	intermediate filament protein	0.0027	0.0021	0.0028
Echinococcus multilocularis	muscleblind protein	0.0162	0.0674	0.0674
Schistosoma mansoni	Smad4	0.0076	0.0259	0.0384
Trichomonas vaginalis	glucosylceramidase, putative	0.103	0.4865	0.6511
Echinococcus granulosus	FKBP12 rapamycin complex associated protein	0.0159	0.0657	0.0657
Echinococcus granulosus	microtubule associated protein 2	0.1416	0.6728	0.6728
Entamoeba histolytica	hypothetical protein	0.0111	0.0428	0.3272
Schistosoma mansoni	tar DNA-binding protein	0.0065	0.0203	0.0302
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0037	0.0069	0.0092
Trichomonas vaginalis	glucosylceramidase, putative	0.157	0.7473	1
Echinococcus granulosus	PIK kinase FAT and Armadillo domain containing protein	0.0029	0.0028	0.0028
Onchocerca volvulus		0.05	0.2307	0.4718
Schistosoma mansoni	cpg binding protein	0.0061	0.0183	0.0273
Trichomonas vaginalis	set domain proteins, putative	0.05	0.2307	0.3087
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0154	0.0633	1
Brugia malayi	MH1 domain containing protein	0.0076	0.0259	0.0346
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0028	0.0038
Schistosoma mansoni	cellular tumor antigen P53	0.0306	0.137	0.2036
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0293	0.1307	0.1749
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0159	0.0657	0.0879
Trypanosoma cruzi	cysteine peptidase, putative	0.0073	0.0244	0.1876
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0101	0.0376	0.0504
Loa Loa (eye worm)	nuclear factor I	0.0042	0.0094	0.0126
Loa Loa (eye worm)	RNA binding protein	0.0065	0.0203	0.0272
Echinococcus granulosus	muscleblind protein	0.0162	0.0674	0.0674
Trypanosoma brucei	phosphatidylinositol 3-related kinase, putative	0.0066	0.0207	0.1592
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0114	0.0439	0.0588
Echinococcus granulosus	cpg binding protein	0.0061	0.0183	0.0183
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.014	0.0566	0.0566
Brugia malayi	MH1 domain containing protein	0.0076	0.0259	0.0346
Trypanosoma brucei	mitochondrial DNA polymerase beta	0.0292	0.13	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.013	0.0518	0.0694
Trypanosoma brucei	DNA polymerase IV, putative	0.004	0.0084	0.0648
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0114	0.0439	0.0439
Loa Loa (eye worm)	transcription factor SMAD2	0.112	0.5298	0.709
Echinococcus granulosus	peregrin	0.0058	0.0173	0.0173
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0052	0.0142	0.0189
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0111	0.0427	0.0565
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0064	0.02	0.0265
Schistosoma mansoni	fkbp-rapamycin associated protein	0.0037	0.0069	0.0102
Leishmania major	target of rapamycin (TOR) kinase 1, putative	0.0159	0.0657	0.5052
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0123	0.0483	0.0647
Trichomonas vaginalis	glucosylceramidase, putative	0.157	0.7473	1
Brugia malayi	PHD-finger family protein	0.0058	0.0173	0.0231
Loa Loa (eye worm)	hypothetical protein	0.009	0.0326	0.0437
Entamoeba histolytica	hypothetical protein	0.0052	0.0142	0.1082
Schistosoma mansoni	survival motor neuron protein	0.0101	0.0376	0.056
Trypanosoma brucei	FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative	0.007	0.0228	0.1752
Schistosoma mansoni	rab geranylgeranyl transferase alpha subunit	0.004	0.0084	0.0125
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0073	0.0244	0.1876
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0094	0.0345	0.0462
Brugia malayi	O-Glycosyl hydrolase family 30 protein	0.157	0.7473	1
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0293	0.1307	0.1749
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0073	0.0244	0.1876
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0094	0.0126
Trichomonas vaginalis	glucosylceramidase, putative	0.103	0.4865	0.6511
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.0292	0.13	1
Mycobacterium tuberculosis	Conserved hypothetical protein	0.004	0.0084	0.1152
Leishmania major	phosphatidylinositol 3-related kinase, putative	0.0066	0.0207	0.1592
Toxoplasma gondii	target of rapamycin (TOR), putative	0.0123	0.0483	0.0639
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.005	0.0132	0.1013
Leishmania major	mitochondrial DNA polymerase beta-PAK, putative	0.0138	0.0557	0.4287
Plasmodium falciparum	importin beta, putative	0.006	0.0178	1
Leishmania major	cathepsin L-like protease	0.0073	0.0244	0.1876
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0073	0.0244	0.1876
Onchocerca volvulus		0.0101	0.0376	0.0734
Trichomonas vaginalis	glucosylceramidase, putative	0.157	0.7473	1
Schistosoma mansoni	hypothetical protein	0.0114	0.0439	0.0653
Trypanosoma brucei	target of rapamycin kinase 3, putative	0.013	0.0519	0.3991
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.0293	0.1307	1
Trypanosoma cruzi	PAB1-binding protein , putative	0.0029	0.003	0.023
Brugia malayi	MH1 domain containing protein	0.0042	0.0094	0.0126
Leishmania major	target of rapamycin (TOR) kinase 2, putative	0.0159	0.0657	0.5052
Toxoplasma gondii	FATC domain-containing protein	0.0052	0.0142	0.0187
Loa Loa (eye worm)	MH1 domain-containing protein	0.0076	0.0259	0.0346
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0055	0.0073
Echinococcus multilocularis	snurportin 1	0.0637	0.2966	0.2966
Schistosoma mansoni	hypothetical protein	0.0114	0.0439	0.0653
Trypanosoma brucei	unspecified product	0.0028	0.0024	0.0185
Leishmania major	phosphatidylinositol kinase related protein, putative	0.0028	0.0024	0.0183
Onchocerca volvulus		0.0057	0.0168	0.0303
Schistosoma mansoni	jumonji domain containing protein	0.0152	0.0625	0.0929
Schistosoma mansoni	terminal deoxycytidyl transferase	0.004	0.0084	0.0125
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0191	0.0815	0.0815
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0021	0.0028
Schistosoma mansoni	cpg binding protein	0.0061	0.0183	0.0273
Trichomonas vaginalis	glucosylceramidase, putative	0.157	0.7473	1
Mycobacterium ulcerans	DNA polymerase IV	0.004	0.0084	0.0619
Giardia lamblia	Fructose-bisphosphate aldolase	0.0293	0.1307	1
Echinococcus granulosus	serine protein kinase ATM	0.0052	0.0142	0.0142
Schistosoma mansoni	smad	0.0034	0.0055	0.0081
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0094	0.0345	0.0462
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0073	0.0244	0.1876
Brugia malayi	MH2 domain containing protein	0.0076	0.0259	0.0346
Trichomonas vaginalis	glucosylceramidase, putative	0.1085	0.5133	0.6869
Trypanosoma cruzi	major cysteine proteinase, putative	0.0058	0.0168	0.1294
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.0292	0.13	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.004	0.0084	0.0648
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0123	0.0483	0.0647
Trypanosoma cruzi	cysteine peptidase, putative	0.0073	0.0244	0.1876
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0066	0.0207	0.0277
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0293	0.1307	0.1749
Echinococcus granulosus	lamin	0.0027	0.0021	0.0021
Schistosoma mansoni	transcription factor LCR-F1	0.0111	0.0428	0.0636
Trypanosoma brucei	DNA polymerase kappa, putative	0.004	0.0084	0.0648
Loa Loa (eye worm)	hypothetical protein	0.0246	0.1077	0.1441
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0067	0.0213	0.164
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0039	0.0081	0.062
Loa Loa (eye worm)	hypothetical protein	0.0162	0.0674	0.0902
Schistosoma mansoni	hypothetical protein	0.0246	0.1077	0.16
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0359	0.1626	0.2176
Echinococcus multilocularis	FKBP12 rapamycin complex associated protein	0.0159	0.0657	0.0657
Mycobacterium ulcerans	hypothetical protein	0.0154	0.0633	0.5374
Brugia malayi	jmjC domain containing protein	0.0191	0.0815	0.1091
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0064	0.02	0.0297
Leishmania major	mitochondrial DNA polymerase beta	0.0292	0.13	1
Brugia malayi	MH2 domain containing protein	0.0076	0.0259	0.0346
Trypanosoma brucei	Phosphatidylinositol 3-kinase tor1	0.0159	0.0657	0.5052
Echinococcus multilocularis	mothers against decapentaplegic 5	0.0076	0.0259	0.0259
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0293	0.1307	0.1749
Echinococcus granulosus	survival motor neuron protein 1	0.0494	0.2275	0.2275
Schistosoma mansoni	tar DNA-binding protein	0.0065	0.0203	0.0302
Brugia malayi	aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase	0.009	0.0326	0.0437
Echinococcus multilocularis	survival motor neuron protein 1	0.0494	0.2275	0.2275
Leishmania major	phosphatidylinositol 3-kinase, putative	0.0066	0.0207	0.1592
Mycobacterium ulcerans	glutaminase	0.0264	0.1166	1
Echinococcus granulosus	importin subunit beta 1	0.006	0.0178	0.0178
Trypanosoma cruzi	DNA polymerase beta thumb, putative	0.0041	0.0088	0.068
Schistosoma mansoni	bromodomain-containing nuclear protein 1 brd1	0.0058	0.0173	0.0256
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0064	0.02	0.0297
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0094	0.0345	0.0461
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.0637	0.2966	0.3969
Echinococcus multilocularis	terminal deoxycytidyl transferase rev1	0.004	0.0084	0.0084
Echinococcus multilocularis	Smad4	0.0076	0.0259	0.0259
Brugia malayi	TAR-binding protein	0.0065	0.0203	0.0272
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0027	0.0021	0.0028
Brugia malayi	jmjC domain containing protein	0.0074	0.0248	0.0332
Brugia malayi	ImpB/MucB/SamB family protein	0.004	0.0084	0.0113
Echinococcus granulosus	terminal deoxycytidyl transferase rev1	0.004	0.0084	0.0084
Onchocerca volvulus	Huntingtin homolog	0.0133	0.0533	0.1057
Onchocerca volvulus	Huntingtin homolog	0.0133	0.0533	0.1057
Echinococcus multilocularis	cpg binding protein	0.0061	0.0183	0.0183
Loa Loa (eye worm)	MH1 domain-containing protein	0.0034	0.0055	0.0073
Brugia malayi	RNA, U transporter 1	0.017	0.0709	0.0949
Trypanosoma cruzi	cruzipain precursor, putative	0.0073	0.0244	0.1876
Toxoplasma gondii	4'-phosphopantetheinyl transferase superfamily protein	0.0025	0.0013	0.0017
Echinococcus multilocularis	dna polymerase kappa	0.004	0.0084	0.0084
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor2	0.0159	0.0657	0.5052
Echinococcus multilocularis	lysine specific demethylase 5A	0.0071	0.0232	0.0232
Leishmania major	phosphopantetheinyl transferase-like protein	0.0025	0.0013	0.0099
Trichomonas vaginalis	glutaminase, putative	0.0264	0.1166	0.156
Loa Loa (eye worm)	hypothetical protein	0.0029	0.003	0.004
Mycobacterium tuberculosis	Probable fructose-bisphosphate aldolase Fba	0.0143	0.0582	0.9191
Schistosoma mansoni	hypothetical protein	0.0521	0.2405	0.3574
Brugia malayi	MH2 domain containing protein	0.112	0.5298	0.709
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0293	0.1307	0.1749
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0061	0.0183	0.0183
Trypanosoma cruzi	target of rapamycin kinase 3	0.013	0.0519	0.3991
Trichomonas vaginalis	PIKK family atypical protein kinase	0.013	0.0518	0.0693
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0094	0.0345	0.0461
Echinococcus granulosus	lysine specific demethylase 5A	0.0074	0.0248	0.0248
Loa Loa (eye worm)	MH2 domain-containing protein	0.0034	0.0055	0.0073
Trypanosoma brucei	DNA polymerase kappa, putative	0.004	0.0084	0.0648
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.014	0.0566	0.0758
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.044	0.2014	0.2695
Trypanosoma brucei	DNA polymerase eta, putative	0.004	0.0084	0.0648
Schistosoma mansoni	smad	0.0076	0.0259	0.0384
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0065	0.0203	0.0272
Loa Loa (eye worm)	TAR-binding protein	0.0065	0.0203	0.0272
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0018	0.0025
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0073	0.0244	0.1876
Loa Loa (eye worm)	jmjC domain-containing protein	0.0074	0.0248	0.0332
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0106	0.04	0.0536
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0111	0.0428	0.0428
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0159	0.0657	0.0879
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0048	0.0124	0.0166
Echinococcus multilocularis	dna polymerase eta	0.004	0.0084	0.0084
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0066	0.0207	0.0277
Echinococcus granulosus	intermediate filament protein	0.0027	0.0021	0.0021
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0123	0.0483	0.0647
Leishmania major	importin beta-1 subunit, putative	0.0048	0.0124	0.0952
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0114	0.0439	0.0439
Schistosoma mansoni	hypothetical protein	0.0111	0.0428	0.0636
Trichomonas vaginalis	DNA polymerase IV / kappa, putative	0.004	0.0084	0.0113
Trypanosoma brucei	phosphatidylinositol 3-kinase, putative	0.0066	0.0207	0.1592
Plasmodium vivax	SET domain protein, putative	0.0064	0.02	1
Echinococcus multilocularis	mothers against decapentaplegic 6	0.0034	0.0055	0.0055
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0064	0.02	0.0297
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0081	0.0108
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0114	0.0439	0.0588
Trichomonas vaginalis	PIKK family atypical protein kinase	0.013	0.0518	0.0693
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0094	0.0345	0.0462
Plasmodium falciparum	ataxin-2 like protein, putative	0.0029	0.003	0.1677
Schistosoma mansoni	hypothetical protein	0.0101	0.0376	0.056
Plasmodium vivax	holo-[acyl-carrier-protein] synthase, putative	0.0025	0.0013	0.0643
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0073	0.0244	0.1876
Trypanosoma brucei	importin beta-1 subunit, putative	0.006	0.0178	0.1371
Trypanosoma brucei	unspecified product	0.004	0.0084	0.0648
Toxoplasma gondii	1,3-beta-glucan synthase component protein	0.1587	0.7558	1
Trypanosoma cruzi	importin beta-1 subunit, putative	0.0048	0.0124	0.0952
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0191	0.0815	0.0815
Echinococcus multilocularis	tumor protein p63	0.2093	1	1
Loa Loa (eye worm)	hypothetical protein	0.0162	0.0674	0.0902
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0074	0.0248	0.0368
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0073	0.0244	0.1876
Trypanosoma brucei	DNA polymerase kappa, putative	0.004	0.0084	0.0648
Leishmania major	hypothetical protein, conserved	0.0029	0.003	0.023
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0293	0.1307	0.1749
Echinococcus multilocularis	muscleblind protein 1	0.0162	0.0674	0.0674
Toxoplasma gondii	hypothetical protein	0.0047	0.0117	0.0155
Loa Loa (eye worm)	Smad1	0.0076	0.0259	0.0346
Echinococcus granulosus	snurportin 1	0.0637	0.2966	0.2966
Echinococcus multilocularis	peregrin	0.0058	0.0173	0.0173
Plasmodium falciparum	holo-[acyl-carrier-protein] synthase, putative	0.0025	0.0013	0.0721
Brugia malayi	MH2 domain containing protein	0.0034	0.0055	0.0073
Trichomonas vaginalis	PIKK family atypical protein kinase	0.013	0.0518	0.0693
Trichomonas vaginalis	glucosylceramidase, putative	0.103	0.4865	0.6511
Echinococcus granulosus	jumonji domain containing protein	0.0081	0.0283	0.0283
Loa Loa (eye worm)	hypothetical protein	0.0114	0.0439	0.0588
Echinococcus multilocularis	GPCR, family 2	0.0114	0.0439	0.0439
Entamoeba histolytica	hypothetical protein	0.0025	0.0013	0.0098
Plasmodium falciparum	phd finger protein, putative	0.0058	0.0173	0.968
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0094	0.0345	0.0462
Trypanosoma brucei	DNA polymerase kappa, putative	0.004	0.0084	0.0648
Loa Loa (eye worm)	intermediate filament protein	0.0027	0.0021	0.0028
Trichomonas vaginalis	conserved hypothetical protein	0.0029	0.0028	0.0038
Schistosoma mansoni	Smad4	0.0034	0.0055	0.0081
Echinococcus multilocularis	lamin dm0	0.0027	0.0021	0.0021
Leishmania major	target of rapamycin kinase (TOR) kinase 3	0.013	0.0519	0.3991
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0073	0.0244	0.1876
Brugia malayi	Muscleblind-like protein	0.0162	0.0674	0.0902
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.014	0.0566	0.0566
Trypanosoma brucei	DNA polymerase beta thumb, putative	0.0041	0.0088	0.068
Schistosoma mansoni	microtubule-associated protein tau	0.1416	0.6728	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0123	0.0483	0.0647
Trypanosoma brucei	mitochondrial DNA polymerase beta-PAK	0.0138	0.0557	0.4287
Entamoeba histolytica	hypothetical protein	0.0111	0.0428	0.3272
Brugia malayi	CXXC zinc finger family protein	0.0057	0.0168	0.0224
Schistosoma mansoni	hypothetical protein	0.0114	0.0439	0.0653
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0101	0.038	0.0509
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0064	0.02	0.02
Echinococcus granulosus	tar DNA binding protein	0.0065	0.0203	0.0203
Echinococcus granulosus	Smad4	0.0076	0.0259	0.0259
Onchocerca volvulus		0.009	0.0326	0.0631
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0028	0.0037
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0094	0.0345	0.0461
Trypanosoma brucei	DNA polymerase kappa, putative	0.004	0.0084	0.0648
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0069	0.0092
Brugia malayi	Latrophilin receptor protein 2	0.0114	0.0439	0.0588
Trypanosoma brucei	DNA polymerase IV, putative	0.004	0.0084	0.0648
Schistosoma mansoni	DNA polymerase eta	0.004	0.0084	0.0125
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0123	0.0483	0.0647
Giardia lamblia	DINP protein human, muc B family	0.004	0.0084	0.0644
Schistosoma mansoni	smad1 5 8 and	0.0076	0.0259	0.0384
Schistosoma mansoni	glutaminase	0.0264	0.1166	0.1733
Echinococcus multilocularis	serine:threonine protein kinase SMG1	0.0037	0.0069	0.0069
Leishmania major	DNA polymerase kappa, putative	0.004	0.0084	0.0648
Entamoeba histolytica	hypothetical protein	0.0048	0.0124	0.0947
Trypanosoma cruzi	DNA polymerase kappa, putative	0.004	0.0084	0.0648
Entamoeba histolytica	phosphatidylinositol3-kinaseTor2, putative	0.0159	0.0657	0.5023
Echinococcus multilocularis	mothers against decapentaplegic 2	0.0034	0.0055	0.0055
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.014	0.0566	0.0758
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.0293	0.1307	1
Brugia malayi	Pre-SET motif family protein	0.044	0.2014	0.2695
Trichomonas vaginalis	PIKK family atypical protein kinase	0.013	0.0518	0.0693
Echinococcus multilocularis	tar DNA binding protein	0.0065	0.0203	0.0203
Trichomonas vaginalis	glucosylceramidase, putative	0.103	0.4865	0.6511
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.0066	0.0207	0.1592
Echinococcus granulosus	dna polymerase eta	0.004	0.0084	0.0084
Echinococcus multilocularis	microtubule associated protein 2	0.1416	0.6728	0.6728
Loa Loa (eye worm)	phosphatidylinositol 3	0.0159	0.0657	0.0879
Trypanosoma cruzi	phosphatidylinositol 3-kinase, putative	0.0037	0.0069	0.0529
Trypanosoma brucei	DNA polymerase kappa, putative	0.0028	0.0024	0.0185
Plasmodium falciparum	ataxin-2 like protein, putative	0.0029	0.003	0.1677
Brugia malayi	Smad1	0.0076	0.0259	0.0346
Leishmania major	DNA polymerase kappa, putative,DNA polymerase IV, putative	0.004	0.0084	0.0648
Loa Loa (eye worm)	phosphatidylinositol 3	0.0066	0.0207	0.0277
Schistosoma mansoni	hypothetical protein	0.0114	0.0439	0.0653
Toxoplasma gondii	HEAT repeat-containing protein	0.006	0.0178	0.0236
Trypanosoma brucei	DNA polymerase IV, putative	0.004	0.0084	0.0648
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0037	0.0069	0.0092
Onchocerca volvulus	Glucosylceramidase homolog	0.103	0.4865	1
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0057	0.0168	0.0224
Trypanosoma cruzi	DNA polymerase kappa, putative	0.004	0.0084	0.0648
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0041	0.0089	0.0119
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0048	0.0124	0.0166
Onchocerca volvulus	Mothers against decapentaplegic homolog	0.0034	0.0055	0.007
Trypanosoma cruzi	DNA polymerase beta thumb, putative	0.0041	0.0088	0.068
Trypanosoma cruzi	DNA polymerase eta, putative	0.004	0.0084	0.0648
Loa Loa (eye worm)	O-glycosyl hydrolase family 30 protein	0.157	0.7473	1
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor1	0.0159	0.0657	0.5052
Brugia malayi	MH1 domain containing protein	0.0042	0.0094	0.0126
Schistosoma mansoni	ataxia telangiectasia mutated (atm)	0.0052	0.0142	0.021
Echinococcus granulosus	GPCR family 2	0.0114	0.0439	0.0439
Echinococcus granulosus	serine:threonine protein kinase SMG1	0.0037	0.0069	0.0069
Trypanosoma brucei	PAB1-binding protein , putative	0.0029	0.003	0.023
Echinococcus multilocularis	geminin	0.0521	0.2405	0.2405
Brugia malayi	hypothetical protein	0.0029	0.003	0.004
Echinococcus granulosus	phosphatidylinositol 3 and 4 kinase	0.0066	0.0207	0.0207
Echinococcus granulosus	PHD finger protein rhinoceros	0.0058	0.0173	0.0173
Mycobacterium tuberculosis	Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed))	0.004	0.0084	0.1152
Schistosoma mansoni	hypothetical protein	0.0058	0.0173	0.0256
Schistosoma mansoni	tar DNA-binding protein	0.0065	0.0203	0.0302
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0066	0.0207	0.0277
Echinococcus granulosus	TGF beta signal transducer SmadC	0.0076	0.0259	0.0259
Echinococcus granulosus	lamin dm0	0.0027	0.0021	0.0021
Trypanosoma cruzi	DNA polymerase kappa, putative	0.004	0.0084	0.0648
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0066	0.0207	0.0277
Echinococcus multilocularis	TGF beta signal transducer SmadC	0.0076	0.0259	0.0259
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0036	0.0063	0.0093
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0123	0.0483	0.0647
Loa Loa (eye worm)	hypothetical protein	0.0359	0.1626	0.2176
Trypanosoma brucei	phosphatidylinositol kinase related protein, putative	0.0052	0.0142	0.1089
Mycobacterium leprae	Probable fructose bisphosphate aldolase Fba	0.0143	0.0582	1
Trichomonas vaginalis	DNA polymerase eta, putative	0.004	0.0084	0.0113
Echinococcus multilocularis	PHD finger protein rhinoceros	0.0058	0.0173	0.0173
Echinococcus granulosus	mothers against decapentaplegic 5	0.0076	0.0259	0.0259
Loa Loa (eye worm)	glutaminase	0.0264	0.1166	0.156
Schistosoma mansoni	Smad4	0.0034	0.0055	0.0081
Echinococcus granulosus	mothers against decapentaplegic 6	0.0034	0.0055	0.0055
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.014	0.0566	0.0842
Echinococcus multilocularis	smad	0.0076	0.0259	0.0259
Wolbachia endosymbiont of Brugia malayi	4'-phosphopantetheinyl transferase	0.0025	0.0013	0.5
Trypanosoma brucei	hypothetical protein, conserved	0.0025	0.0013	0.0099
Onchocerca volvulus		0.0064	0.02	0.037
Loa Loa (eye worm)	hypothetical protein	0.006	0.0178	0.0239
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0037	0.0069	0.0092
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0173	0.0231
Loa Loa (eye worm)	hypothetical protein	0.0064	0.02	0.0268
Loa Loa (eye worm)	hypothetical protein	0.0306	0.137	0.1833
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0066	0.0207	0.0277
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.0159	0.0657	0.5052
Trypanosoma cruzi	DNA polymerase kappa, putative	0.004	0.0084	0.0648
Entamoeba histolytica	hypothetical protein	0.0111	0.0428	0.3272
Trichomonas vaginalis	PIKK family atypical protein kinase	0.013	0.0518	0.0693
Echinococcus multilocularis	musashi	0.0027	0.0021	0.0021
Schistosoma mansoni	TGF-beta signal transducer Smad2	0.0076	0.0259	0.0384
Toxoplasma gondii	non-specific serine/threonine protein kinase	0.0041	0.0089	0.0118
Trypanosoma brucei	DNA polymerase kappa, putative	0.004	0.0084	0.0648
Plasmodium vivax	hypothetical protein, conserved	0.0058	0.0173	0.8628
Trypanosoma brucei	DNA polymerase kappa, putative	0.0028	0.0024	0.0185
Echinococcus multilocularis	PIK kinase, FAT and Armadillo domain containing protein	0.0029	0.0028	0.0028
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0024	0.0008	0.001
Loa Loa (eye worm)	hypothetical protein	0.0133	0.0533	0.0713
Schistosoma mansoni	hypothetical protein	0.0637	0.2966	0.4408
Schistosoma mansoni	smad1 5 8 and	0.0076	0.0259	0.0384
Brugia malayi	Bromodomain containing protein	0.0058	0.0173	0.0231
Toxoplasma gondii	4'-phosphopantetheinyl transferase domain-containing protein	0.0025	0.0013	0.0017
Loa Loa (eye worm)	hypothetical protein	0.004	0.0084	0.0113
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0073	0.0244	0.1876
Brugia malayi	F/Y-rich N-terminus family protein	0.0039	0.0078	0.0105
Entamoeba histolytica	Phosphatidylinositol 3- and 4-kinase family	0.0037	0.0069	0.0526
Echinococcus granulosus	histone lysine methyltransferase setb	0.0064	0.02	0.02
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0041	0.0088	0.068
Trypanosoma brucei	phosphatidylinositol 3-kinase tor, putative	0.007	0.0227	0.175
Brugia malayi	ImpB/MucB/SamB family protein	0.004	0.0084	0.0113
Echinococcus granulosus	geminin	0.0521	0.2405	0.2405
Trichomonas vaginalis	importin beta-1, putative	0.0048	0.0124	0.0166
Brugia malayi	glutaminase DH11.1	0.0264	0.1166	0.156
Schistosoma mansoni	hypothetical protein	0.0521	0.2405	0.3574
Trichomonas vaginalis	conserved hypothetical protein	0.0024	0.0008	0.001
Plasmodium vivax	ataxin-2 like protein, putative	0.0029	0.003	0.1495
Giardia lamblia	GTOR	0.0159	0.0657	0.5023
Schistosoma mansoni	tar DNA-binding protein	0.0065	0.0203	0.0302
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0052	0.0142	0.1089
Trichomonas vaginalis	conserved hypothetical protein	0.0041	0.0089	0.0119
Entamoeba histolytica	protein kinase rad3, putative	0.0037	0.0069	0.0526
Schistosoma mansoni	lamin	0.0027	0.0021	0.0031
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0293	0.1307	0.1749
Trypanosoma cruzi	cysteine peptidase, putative	0.0073	0.0244	0.1876
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0101	0.038	0.0509
Trypanosoma brucei	importin beta-1 subunit, putative	0.006	0.0178	0.1371
Treponema pallidum	fructose-bisphosphate aldolase	0.0293	0.1307	1
Trichomonas vaginalis	glucosylceramidase, putative	0.1085	0.5133	0.6869
Schistosoma mansoni	aminoadipate-semialdehyde dehydrogenase	0.009	0.0326	0.0485
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0138	0.0557	0.4287
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0074	0.0248	0.0368
Loa Loa (eye worm)	PHD-finger family protein	0.0058	0.0173	0.0231
Echinococcus multilocularis	jumonji domain containing protein	0.0081	0.0283	0.0283
Brugia malayi	Intermediate filament tail domain containing protein	0.0027	0.0021	0.0028
Echinococcus multilocularis	L aminoadipate semialdehyde	0.009	0.0326	0.0326
Leishmania major	DNA polymerase eta, putative	0.004	0.0084	0.0648
Brugia malayi	hypothetical protein	0.0111	0.0428	0.0572
Trypanosoma brucei	DNA polymerase kappa, putative	0.004	0.0084	0.0648
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0089	0.0119
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0066	0.0207	0.0277
Trichomonas vaginalis	glucosylceramidase, putative	0.157	0.7473	1
Toxoplasma gondii	PHD-finger domain-containing protein	0.0058	0.0173	0.0228
Echinococcus granulosus	mothers against decapentaplegic 2	0.0034	0.0055	0.0055
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0123	0.0483	0.0647
Schistosoma mansoni	phosphatidylinositol 3-and 4-kinase	0.0066	0.0207	0.0307
Trichomonas vaginalis	glucosylceramidase, putative	0.157	0.7473	1
Brugia malayi	mothers against decapentaplegic homolog 3	0.0034	0.0055	0.0073
Trypanosoma cruzi	PAB1-binding protein , putative	0.0029	0.003	0.023
Schistosoma mansoni	intermediate filament proteins	0.0027	0.0021	0.0031
Giardia lamblia	PHD finger protein 15	0.0058	0.0173	0.132
Trichomonas vaginalis	glucosylceramidase, putative	0.103	0.4865	0.6511
Trypanosoma brucei	DNA polymerase kappa, putative	0.004	0.0084	0.0648
Mycobacterium ulcerans	fructose-bisphosphate aldolase	0.0143	0.0582	0.494
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0094	0.0345	0.0462
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.014	0.0566	0.0842
Brugia malayi	Importin beta-1 subunit	0.006	0.0178	0.0239
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0359	0.1626	0.2176
Brugia malayi	RNA recognition motif domain containing protein	0.0065	0.0203	0.0272
Trichomonas vaginalis	glucosylceramidase, putative	0.103	0.4865	0.6511
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0159	0.0657	0.0879
Brugia malayi	hypothetical protein	0.0494	0.2275	0.3044
Loa Loa (eye worm)	hypothetical protein	0.0133	0.0533	0.0713
Echinococcus granulosus	smad	0.0076	0.0259	0.0259
Loa Loa (eye worm)	ImpB/MucB/SamB family protein	0.004	0.0084	0.0113
Trypanosoma brucei	DNA polymerase kappa, putative	0.0028	0.0024	0.0185
Loa Loa (eye worm)	MH2 domain-containing protein	0.112	0.5298	0.709
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0028	0.0024	0.0183
Loa Loa (eye worm)	MH2 domain-containing protein	0.0076	0.0259	0.0346
Trichomonas vaginalis	glucosylceramidase, putative	0.103	0.4865	0.6511
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0064	0.02	0.02
Loa Loa (eye worm)	jmjC domain-containing protein	0.0121	0.0473	0.0633
Echinococcus granulosus	L aminoadipate semialdehyde	0.009	0.0326	0.0326
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0073	0.0244	0.1876
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.0066	0.0207	0.1592
Trypanosoma brucei	unspecified product	0.0028	0.0024	0.0185
Schistosoma mansoni	ataxia telangiectasia mutated (atm)-related	0.0159	0.0657	0.0976
Brugia malayi	FAT domain containing protein	0.0029	0.0028	0.0038
Plasmodium vivax	importin-beta 2, putative	0.006	0.0178	0.8913
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.014	0.0566	0.0566
Chlamydia trachomatis	holo [acyl-carrier protein] synthase	0.0025	0.0013	0.5
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0111	0.0428	0.0428
Onchocerca volvulus	Alhambra homolog	0.0058	0.0173	0.0313
Loa Loa (eye worm)	hypothetical protein	0.0494	0.2275	0.3044
Mycobacterium ulcerans	DNA polymerase IV	0.004	0.0084	0.0619
Brugia malayi	RNA binding protein	0.0065	0.0203	0.0272
Entamoeba histolytica	hypothetical protein	0.0111	0.0428	0.3272
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0114	0.0439	0.0439
Toxoplasma gondii	LsmAD domain-containing protein	0.0029	0.003	0.004
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0094	0.0345	0.0462
Echinococcus multilocularis	lamin	0.0027	0.0021	0.0021
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0293	0.1307	0.1749
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0094	0.0345	0.0462
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0359	0.1626	0.2176
Echinococcus multilocularis	serine protein kinase ATM	0.0052	0.0142	0.0142
Entamoeba histolytica	FKBP-rapamycin associated protein (FRAP), putative	0.0159	0.0657	0.5023
Schistosoma mansoni	tar DNA-binding protein	0.0065	0.0203	0.0302
Toxoplasma gondii	PHD-finger domain-containing protein	0.0058	0.0173	0.0228
Brugia malayi	hypothetical protein	0.0133	0.0533	0.0713
Schistosoma mansoni	cpg binding protein	0.0057	0.0168	0.0249
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0114	0.0439	0.0439
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0159	0.0657	0.0879

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 186 uM	Inhibition of Torpedo californica AChE	ChEMBL.	16913695
Inhibition (binding)	= 13 %	Inhibition of AChE in CD1 mouse brain at 11 mg/kg, po after 6 hrs	ChEMBL.	16913695

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL538603

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1031061