Detailed information for compound 1031682

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 268.097 | Formula: C8H11Cl2N3O3
  • H donors: 2 H acceptors: 4 LogP: 1.67 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: Oc1nc(O)c(c(n1)N1CCOCC1)Cl.Cl
  • InChi: 1S/C8H10ClN3O3.ClH/c9-5-6(10-8(14)11-7(5)13)12-1-3-15-4-2-12;/h1-4H2,(H2,10,11,13,14);1H
  • InChiKey: HYEIMQTUVHKNSV-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Escherichia coli thymidine phosphorylase Starlite/ChEMBL References
Homo sapiens thymidine phosphorylase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Mycobacterium ulcerans thymidine phosphorylase Get druggable targets OG5_131632 All targets in OG5_131632
Echinococcus granulosus thymidine phosphorylase Get druggable targets OG5_131632 All targets in OG5_131632
Echinococcus multilocularis thymidine phosphorylase Get druggable targets OG5_131632 All targets in OG5_131632
Mycobacterium tuberculosis Probable thymidine phosphorylase DeoA (tdrpase) (pyrimidine phosphorylase) Get druggable targets OG5_131632 All targets in OG5_131632
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni aldehyde dehydrogenase 0.0125 0.0698 0.0814
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0043 0.0127
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0014 0.0005 0.0014
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0031 0.0064
Schistosoma mansoni lamin 0.0027 0.0087 0.0101
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0241 0.1431 0.15
Loa Loa (eye worm) hypothetical protein 0.0063 0.0314 0.0644
Plasmodium vivax glycogen synthase kinase 3, putative 0.0558 0.3423 1
Entamoeba histolytica Ran family GTPase 0.0021 0.005 0.013
Plasmodium falciparum metacaspase 1 0.0063 0.0314 0.0917
Echinococcus multilocularis caspase 8 0.0063 0.0314 0.0314
Leishmania major acetoin dehydrogenase e3 component-like protein 0.005 0.0233 0.0681
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0031 0.0064
Echinococcus multilocularis thioredoxin glutathione reductase 0.0146 0.0832 0.0832
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0125 0.0698 0.0732
Mycobacterium tuberculosis Probable bacterioferritin BfrA 0.0017 0.0025 0.0026
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0075 0.0384 0.1123
Echinococcus multilocularis jumonji domain containing 1A 0.0017 0.0021 0.0021
Echinococcus multilocularis ferritin 0.0017 0.0025 0.0025
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0031 0.0064
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0018 0.0031 0.0082
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0037 0.0149 0.0306
Mycobacterium ulcerans anthranilate phosphoribosyltransferase 0.0432 0.2632 0.2759
Onchocerca volvulus Cell death protein 3 homolog 0.0148 0.0848 0.2477
Echinococcus multilocularis Polycystic kidney disease protein 0.002 0.0042 0.0042
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0031 0.0064
Plasmodium falciparum glycogen synthase kinase 3 0.0558 0.3423 1
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0033 0.0124 0.0362
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0146 0.0832 0.0872
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0046 0.0208 0.0426
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0018 0.0031 0.0091
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0155 0.0318
Trypanosoma cruzi trypanothione reductase, putative 0.0146 0.0832 0.2429
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0072 0.0211
Trypanosoma cruzi metacaspase, putative 0.0063 0.0314 0.0917
Mycobacterium tuberculosis Probable thymidine phosphorylase DeoA (tdrpase) (pyrimidine phosphorylase) 0.1531 0.9538 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0004 0.0011
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0155 0.0452
Trichomonas vaginalis conserved hypothetical protein 0.0063 0.0314 0.0644
Giardia lamblia Kinase, CMGC GSK 0.0558 0.3423 0.9003
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0241 0.1431 0.4179
Mycobacterium ulcerans thymidine phosphorylase 0.1531 0.9538 1
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0125 0.0698 0.204
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.005 0.0233 0.0681
Mycobacterium tuberculosis Probable anthranilate phosphoribosyltransferase TrpD 0.0432 0.2632 0.2759
Mycobacterium tuberculosis Probable dehydrogenase 0.0332 0.2005 0.2102
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0056 0.0268 0.0268
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0025 0.0074 0.0152
Trypanosoma brucei metacaspase MCA2 0.0063 0.0314 0.0917
Brugia malayi Glycosyl hydrolases family 31 protein 0.0014 0.0005 0.001
Echinococcus multilocularis lysine specific demethylase 6a 0.0017 0.0021 0.0021
Echinococcus granulosus protein kinase shaggy 0.0558 0.3423 0.3589
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0241 0.1431 0.1431
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0332 0.2005 0.2102
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0072 0.0211
Schistosoma mansoni loxhd1 0.002 0.0042 0.0048
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0155 0.0318
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.005 0.0233 0.0244
Schistosoma mansoni rab6-interacting 0.002 0.0042 0.0048
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0074 0.0152
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0038 0.0155 0.0318
Trypanosoma brucei unspecified product 0.0014 0.0004 0.0011
Leishmania major DNA polymerase kappa, putative 0.002 0.0043 0.0127
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0083 0.0438 0.1278
Schistosoma mansoni hypothetical protein 0.1031 0.6398 0.7455
Echinococcus granulosus mitogen activated protein kinase 0.0057 0.0274 0.0288
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.0137 0.0776 0.0813
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0158 0.0909 0.0953
Plasmodium vivax thioredoxin reductase, putative 0.0146 0.0832 0.2429
Onchocerca volvulus 0.0152 0.0869 0.2538
Brugia malayi MH2 domain containing protein 0.0127 0.0714 0.1465
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0063 0.0314 0.0644
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.005 0.0233 0.0681
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0098 0.0285
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0139 0.0146
Brugia malayi mucosa associated lymphoid tissue lymphoma translocation protein 1 0.0063 0.0314 0.0644
Entamoeba histolytica protein kinase, putative 0.0558 0.3423 0.9003
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0025 0.0074 0.0086
Toxoplasma gondii thioredoxin reductase 0.0146 0.0832 0.2429
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.005 0.0145
Trichomonas vaginalis CMGC family protein kinase 0.0057 0.0274 0.0563
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.002 0.0043 0.0089
Loa Loa (eye worm) hypothetical protein 0.0017 0.0021 0.0042
Mycobacterium tuberculosis Bacterioferritin BfrB 0.0017 0.0025 0.0026
Schistosoma mansoni alpha-glucosidase 0.0148 0.0843 0.0983
Giardia lamblia Kinase, CMGC MAPK 0.0057 0.0274 0.0722
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0063 0.0314 0.0917
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0072 0.0211
Brugia malayi cytoplasmic intermediate filament protein 0.0015 0.0008 0.0015
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.0005 0.001
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0241 0.1431 0.5435
Brugia malayi jmjC domain containing protein 0.0017 0.0021 0.0042
Brugia malayi Doublecortin family protein 0.002 0.0042 0.0085
Trichomonas vaginalis glucosylceramidase, putative 0.0518 0.3169 0.6502
Echinococcus granulosus lysine specific demethylase 5A 0.0064 0.0319 0.0335
Onchocerca volvulus 0.0029 0.0097 0.0283
Schistosoma mansoni protein phosphatase 2C 0.0017 0.0021 0.0024
Echinococcus multilocularis neuropeptide s receptor 0.0469 0.2865 0.2865
Trichomonas vaginalis glucosylceramidase, putative 0.0789 0.4874 1
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0075 0.0384 0.0789
Echinococcus multilocularis importin subunit beta 1 0.0029 0.0098 0.0098
Echinococcus granulosus importin subunit beta 1 0.0029 0.0098 0.0102
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0558 0.3423 0.7025
Schistosoma mansoni alpha-glucosidase 0.0148 0.0843 0.0983
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0031 0.0064
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0056 0.0268 0.0281
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0043 0.0127
Toxoplasma gondii HEAT repeat-containing protein 0.0029 0.0098 0.0285
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0208 0.0242
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0042 0.0044
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0043 0.0127
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0018 0.0031 0.0091
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0031 0.0064
Trypanosoma brucei protein kinase, putative 0.0057 0.0274 0.0801
Onchocerca volvulus 0.002 0.0042 0.0121
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0043 0.0127
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0018 0.0031 0.0091
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.005 0.0233 0.0478
Schistosoma mansoni importin beta-1 0.0029 0.0098 0.0114
Brugia malayi jmjC domain containing protein 0.0064 0.0319 0.0655
Schistosoma mansoni polycystin 1-related 0.002 0.0042 0.0048
Leishmania major metacaspase, putative 0.0063 0.0314 0.0917
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0332 0.2005 0.2102
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0031 0.0064
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0075 0.0384 0.0403
Mycobacterium ulcerans aldehyde dehydrogenase 0.0125 0.0698 0.0732
Trypanosoma cruzi DNA polymerase eta, putative 0.0033 0.0124 0.0362
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0302 0.1814 0.1902
Loa Loa (eye worm) hypothetical protein 0.0152 0.0869 0.1783
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0241 0.1431 0.4179
Echinococcus multilocularis muscleblind protein 1 0.0302 0.1813 0.1813
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0302 0.1814 0.6894
Schistosoma mansoni ferritin 0.0017 0.0025 0.0029
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0063 0.0314 0.0644
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.005 0.0233 0.0681
Trichomonas vaginalis conserved hypothetical protein 0.0063 0.0314 0.0644
Loa Loa (eye worm) hypothetical protein 0.0022 0.0052 0.0107
Loa Loa (eye worm) thioredoxin reductase 0.0146 0.0832 0.1706
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0087 0.0179
Loa Loa (eye worm) hypothetical protein 0.0148 0.0848 0.174
Brugia malayi hypothetical protein 0.0036 0.0139 0.0285
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0043 0.0127
Echinococcus multilocularis expressed protein 0.0017 0.0025 0.0025
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.005 0.0233 0.163
Echinococcus granulosus expressed protein 0.0017 0.0025 0.0026
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0057 0.0274 0.0801
Plasmodium falciparum glutathione reductase 0.0146 0.0832 0.2429
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0158 0.0909 0.0953
Brugia malayi Importin beta-1 subunit 0.0029 0.0098 0.02
Leishmania major dihydrolipoamide dehydrogenase, putative 0.005 0.0233 0.0681
Loa Loa (eye worm) phosphatidylinositol 3 0.0018 0.0031 0.0064
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0054 0.0256 0.0525
Trichomonas vaginalis glutathione reductase, putative 0.005 0.0233 0.0478
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.005 0.005
Schistosoma mansoni jumonji domain containing protein 0.0063 0.0309 0.036
Echinococcus granulosus RUN 0.002 0.0042 0.0044
Loa Loa (eye worm) latrophilin receptor protein 2 0.0047 0.0214 0.0439
Brugia malayi CXXC zinc finger family protein 0.0029 0.0097 0.0199
Echinococcus granulosus jumonji domain containing 1A 0.0017 0.0021 0.0022
Echinococcus granulosus lamin 0.0027 0.0087 0.0091
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.005 0.0233 0.0681
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0018 0.0031 0.0091
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.005 0.0233 0.0272
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0063 0.0309 0.0324
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0066 0.033 0.0346
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0038 0.0155 0.0318
Schistosoma mansoni rab6-interacting 0.002 0.0042 0.0048
Echinococcus multilocularis caspase 3 0.0073 0.0378 0.0378
Loa Loa (eye worm) MH2 domain-containing protein 0.0127 0.0714 0.1465
Loa Loa (eye worm) hypothetical protein 0.0027 0.0084 0.0172
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.005 0.0145
Onchocerca volvulus Glucosylceramidase homolog 0.0518 0.3169 0.9256
Mycobacterium tuberculosis Probable reductase 0.0332 0.2005 0.2102
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0618 0.3803 0.7803
Giardia lamblia NADH oxidase lateral transfer candidate 0.005 0.0233 0.0613
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0063 0.0314 0.0644
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0031 0.0064
Schistosoma mansoni hypothetical protein 0.0309 0.1857 0.2164
Echinococcus multilocularis muscleblind protein 0.0302 0.1813 0.1813
Echinococcus multilocularis lamin 0.0027 0.0087 0.0087
Echinococcus multilocularis thymidine phosphorylase 0.1531 0.9538 0.9538
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0369 0.2238 0.2346
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0063 0.0314 0.0644
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0038 0.0155 0.0407
Leishmania major trypanothione reductase 0.0146 0.0832 0.2429
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0241 0.1431 1
Schistosoma mansoni peptidase Clp (S14 family) 0.0241 0.1431 0.1667
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.005 0.0233 0.0244
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0302 0.1814 0.1902
Trypanosoma brucei metacaspase 0.0063 0.0314 0.0917
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0018 0.0031 0.0036
Echinococcus multilocularis neuropeptide receptor A26 0.0469 0.2865 0.2865
Plasmodium vivax importin-beta 2, putative 0.0029 0.0098 0.0285
Giardia lamblia DINP protein human, muc B family 0.002 0.0043 0.0114
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.0005 0.001
Echinococcus multilocularis dnaJ subfamily B 0.041 0.2496 0.2496
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0208 0.0218
Trypanosoma brucei protein kinase, putative 0.0558 0.3423 1
Trichomonas vaginalis glucosylceramidase, putative 0.0518 0.3169 0.6502
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0558 0.3423 0.7025
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.005 0.0233 0.0681
Echinococcus granulosus caspase 2 0.0148 0.0848 0.0889
Trypanosoma cruzi metacaspase, putative 0.0063 0.0314 0.0917
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.002 0.0043 0.0043
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0043 0.0089
Echinococcus granulosus inositol monophosphatase 1 0.0075 0.0384 0.0403
Echinococcus granulosus mitogen activated protein kinase 3 0.0057 0.0274 0.0288
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.005 0.0102
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0017 0.0021 0.006
Toxoplasma gondii FATC domain-containing protein 0.0025 0.0074 0.0217
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0618 0.3803 0.7803
Trichomonas vaginalis mercuric reductase, putative 0.005 0.0233 0.0478
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.0005 0.001
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0014 0.0005 0.001
Trypanosoma brucei Metacaspase-4 0.0063 0.0314 0.0917
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0061 0.03 0.035
Brugia malayi Glycosyl hydrolases family 31 protein 0.0171 0.0993 0.2038
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0087 0.0179
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0022 0.0052 0.0152
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0018 0.0031 0.0031
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0043 0.0127
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0031 0.0064
Entamoeba histolytica hypothetical protein 0.0036 0.0139 0.0366
Brugia malayi hypothetical protein 0.0085 0.045 0.0923
Echinococcus granulosus caspase 8 0.0063 0.0314 0.0329
Echinococcus multilocularis mitogen activated protein kinase 0.0057 0.0274 0.0274
Mycobacterium ulcerans bacterioferritin BfrA 0.0017 0.0025 0.0026
Schistosoma mansoni hypothetical protein 0.002 0.0042 0.0048
Loa Loa (eye worm) hypothetical protein 0.0302 0.1813 0.3719
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0072 0.0211
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0618 0.3803 1
Trypanosoma cruzi trypanothione reductase, putative 0.005 0.0233 0.0681
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0063 0.0314 0.0644
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.0005 0.001
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0075 0.0384 0.1123
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0072 0.0211
Brugia malayi hypothetical protein 0.0152 0.0869 0.1783
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0139 0.0139
Echinococcus multilocularis peptidase Clp (S14 family) 0.0158 0.0909 0.0909
Echinococcus multilocularis dna polymerase eta 0.0047 0.0212 0.0212
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0057 0.0274 0.0801
Trichomonas vaginalis sucrase-isomaltase, putative 0.0038 0.0155 0.0318
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0066 0.033 0.0677
Schistosoma mansoni microtubule-associated protein tau 0.1379 0.8582 1
Plasmodium vivax multidomain scavenger receptor, putative 0.002 0.0042 0.0121
Trichomonas vaginalis glucosylceramidase, putative 0.0789 0.4874 1
Loa Loa (eye worm) doublecortin family protein 0.002 0.0042 0.0085
Schistosoma mansoni caspase-7 (C14 family) 0.0148 0.0848 0.0988
Echinococcus multilocularis mitogen activated protein kinase 3 0.0057 0.0274 0.0274
Echinococcus multilocularis snurportin 1 0.0309 0.1857 0.1857
Schistosoma mansoni ferritin 0.0017 0.0025 0.0029
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0042 0.0044
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0018 0.0031 0.0033
Trichomonas vaginalis conserved hypothetical protein 0.0063 0.0314 0.0644
Trypanosoma cruzi metacaspase, putative 0.0063 0.0314 0.0917
Loa Loa (eye worm) hypothetical protein 0.0047 0.0212 0.0435
Onchocerca volvulus 0.0099 0.0539 0.1575
Echinococcus granulosus neuropeptide s receptor 0.0469 0.2865 0.3004
Schistosoma mansoni DNA polymerase eta 0.0047 0.0212 0.0247
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0063 0.0314 0.0644
Mycobacterium ulcerans aldehyde dehydrogenase 0.0125 0.0698 0.0732
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0031 0.0064
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0075 0.0384 0.1123
Loa Loa (eye worm) transcription factor SMAD2 0.0127 0.0714 0.1465
Toxoplasma gondii target of rapamycin (TOR), putative 0.0018 0.0031 0.0091
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.0558 0.3423 1
Schistosoma mansoni hypothetical protein 0.0047 0.0214 0.0249
Plasmodium vivax hypothetical protein, conserved 0.0063 0.0314 0.0917
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0098 0.0285
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0043 0.0127
Leishmania major hypothetical protein, conserved 0.0017 0.0021 0.006
Schistosoma mansoni hypothetical protein 0.0047 0.0214 0.0249
Treponema pallidum fructose-bisphosphate aldolase 0.0618 0.3803 1
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0017 0.0021 0.0024
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0066 0.033 0.0964
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.002 0.0043 0.0051
Echinococcus multilocularis caspase 2 0.0148 0.0848 0.0848
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0031 0.0064
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.005 0.0233 0.0681
Trichomonas vaginalis glucosylceramidase, putative 0.0789 0.4874 1
Echinococcus granulosus ferritin 0.0017 0.0025 0.0026
Trypanosoma brucei DNA polymerase eta, putative 0.0047 0.0212 0.0619
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0038 0.0155 0.0452
Echinococcus granulosus lamin dm0 0.0027 0.0087 0.0091
Leishmania major alpha glucosidase II subunit, putative 0.0038 0.0155 0.0452
Echinococcus granulosus intermediate filament protein 0.0027 0.0087 0.0091
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0241 0.1431 0.15
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.005 0.0233 0.0681
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0004 0.0011
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.005 0.0233 0.163
Echinococcus granulosus muscleblind protein 0.0302 0.1813 0.19
Entamoeba histolytica hypothetical protein 0.0036 0.0139 0.0366
Schistosoma mansoni cpg binding protein 0.003 0.0107 0.0125
Echinococcus granulosus lysosomal alpha glucosidase 0.0171 0.0993 0.1041
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0139 0.0162
Schistosoma mansoni apoferritin-2 0.0017 0.0025 0.0029
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0042 0.0042
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0125 0.0698 0.0698
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0083 0.0438 0.1663
Brugia malayi jmjC domain containing protein 0.0017 0.0021 0.0042
Loa Loa (eye worm) hypothetical protein 0.0241 0.1431 0.2935
Loa Loa (eye worm) hypothetical protein 0.0025 0.0072 0.0148
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0241 0.1431 1
Echinococcus granulosus cpg binding protein 0.003 0.0107 0.0112
Plasmodium falciparum thioredoxin reductase 0.0146 0.0832 0.2429
Echinococcus granulosus peptidase Clp S14 family 0.0158 0.0909 0.0953
Mycobacterium ulcerans bacterioferritin BfrB 0.0017 0.0025 0.0026
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0031 0.0064
Schistosoma mansoni jumonji/arid domain-containing protein 0.0064 0.0319 0.0372
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0038 0.0155 0.0407
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0066 0.033 0.0346
Schistosoma mansoni lipoxygenase 0.0056 0.0268 0.0312
Toxoplasma gondii hypothetical protein 0.0083 0.0438 0.1278
Echinococcus granulosus GPCR family 2 0.0047 0.0214 0.0224
Loa Loa (eye worm) hypothetical protein 0.0014 0.0005 0.001
Onchocerca volvulus 0.002 0.0042 0.0121
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.0558 0.3423 0.3423
Brugia malayi hypothetical protein 0.002 0.0042 0.0085
Echinococcus granulosus serine protein kinase ATM 0.0025 0.0074 0.0078
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0057 0.0274 0.0801
Giardia lamblia GTOR 0.0018 0.0031 0.0082
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0025 0.0074 0.0217
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0066 0.033 0.033
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.005 0.0145
Loa Loa (eye worm) hypothetical protein 0.0102 0.056 0.1148
Brugia malayi hypothetical protein 0.0016 0.0017 0.0034
Echinococcus multilocularis GPCR, family 2 0.0047 0.0214 0.0214
Schistosoma mansoni jumonji/arid domain-containing protein 0.0064 0.0319 0.0372
Onchocerca volvulus 0.0085 0.045 0.1314
Schistosoma mansoni intermediate filament proteins 0.0027 0.0087 0.0101
Entamoeba histolytica protein kinase domain containing protein 0.0558 0.3423 0.9003
Trichomonas vaginalis inositol monophosphatase, putative 0.0075 0.0384 0.0789
Mycobacterium ulcerans aldehyde dehydrogenase 0.0125 0.0698 0.0732
Toxoplasma gondii NADPH-glutathione reductase 0.005 0.0233 0.0681
Brugia malayi Probable ClpP-like protease 0.0241 0.1431 0.2935
Mycobacterium tuberculosis Conserved hypothetical protein 0.002 0.0043 0.0046
Loa Loa (eye worm) hypothetical protein 0.0085 0.045 0.0923
Schistosoma mansoni ferritin light chain 0.0017 0.0025 0.0029
Wolbachia endosymbiont of Brugia malayi bacterioferritin/cytochrome b1 0.0017 0.0025 0.0175
Mycobacterium leprae Probable anthranilate phosphoribosyltransferase TrpD 0.0432 0.2632 1
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0018 0.0031 0.0031
Schistosoma mansoni cpg binding protein 0.0029 0.0097 0.0113
Echinococcus multilocularis serine protein kinase ATM 0.0025 0.0074 0.0074
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0018 0.0031 0.0091
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0017 0.0021 0.006
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0208 0.0208
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0047 0.0214 0.0224
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0072 0.0211
Brugia malayi jmjC domain containing protein 0.0063 0.0309 0.0634
Echinococcus granulosus dna polymerase kappa 0.002 0.0043 0.0046
Echinococcus granulosus phd:f box containing protein 0.0017 0.0021 0.0022
Echinococcus granulosus neutral alpha glucosidase AB 0.0038 0.0155 0.0162
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0018 0.0031 0.0091
Echinococcus granulosus thymidine phosphorylase 0.1531 0.9538 1
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0097 0.0199
Trichomonas vaginalis CMGC family protein kinase 0.0057 0.0274 0.0563
Leishmania major importin beta-1 subunit, putative 0.0023 0.0063 0.0185
Echinococcus multilocularis musashi 0.0027 0.0087 0.0087
Brugia malayi hypothetical protein 0.0025 0.0072 0.0148
Echinococcus multilocularis apoptotic protease activating factor 1 0.0085 0.045 0.045
Brugia malayi intracellular kinase 0.0558 0.3423 0.7025
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0066 0.033 0.0346
Schistosoma mansoni cpg binding protein 0.003 0.0107 0.0125
Brugia malayi MAP kinase sur-1 0.0057 0.0274 0.0563
Echinococcus granulosus caspase 0.0137 0.0776 0.0813
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.005 0.0233 0.0233
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0018 0.0031 0.0092
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0031 0.0064
Schistosoma mansoni subfamily C14A unassigned peptidase (C14 family) 0.0063 0.0314 0.0366
Echinococcus granulosus Polycystic kidney disease protein 0.002 0.0042 0.0044
Leishmania major hypothetical protein, conserved 0.0025 0.0072 0.0211
Plasmodium falciparum importin beta, putative 0.0029 0.0098 0.0285
Trypanosoma brucei metacaspase MCA3 0.0063 0.0314 0.0917
Trypanosoma cruzi target of rapamycin kinase 3 0.0018 0.0031 0.0091
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0018 0.0031 0.0091
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0241 0.1431 0.4179
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0018 0.0031 0.0031
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0057 0.0274 0.0801
Brugia malayi Latrophilin receptor protein 2 0.0047 0.0214 0.0439
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.005 0.0233 0.0681
Brugia malayi Cell death protein 3 precursor 0.0148 0.0848 0.174
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.002 0.0043 0.0089
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0017 0.0021 0.006
Plasmodium vivax JmjC domain containing protein 0.0017 0.0021 0.006
Loa Loa (eye worm) jmjC domain-containing protein 0.0064 0.0319 0.0655
Trichomonas vaginalis ran, putative 0.0021 0.005 0.0102
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0043 0.0127
Toxoplasma gondii histone lysine methyltransferase SET1 0.0055 0.0259 0.0756
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0063 0.0314 0.0644
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0018 0.0031 0.0091
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0018 0.0031 0.0064
Schistosoma mansoni ferritin 0.0017 0.0025 0.0029
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0063 0.0314 0.0644
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0018 0.0031 0.0091
Brugia malayi RNA, U transporter 1 0.0082 0.0433 0.0888
Schistosoma mansoni apoferritin-2 0.0017 0.0025 0.0029
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0369 0.2238 0.2346
Schistosoma mansoni hypothetical protein 0.0102 0.056 0.0652
Leishmania major DNA polymerase eta, putative 0.0033 0.0124 0.0362
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0155 0.0318
Treponema pallidum NADH oxidase 0.005 0.0233 0.0613
Trypanosoma brucei trypanothione reductase 0.0146 0.0832 0.2429
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0066 0.033 0.0384
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0083 0.0438 0.1278
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0031 0.0064
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0155 0.0318
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0083 0.0438 0.1151
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0031 0.0064
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0043 0.0127
Echinococcus multilocularis lysosomal alpha glucosidase 0.0171 0.0993 0.0993
Echinococcus multilocularis neutral alpha glucosidase AB 0.0038 0.0155 0.0155
Trichomonas vaginalis glucosylceramidase, putative 0.0518 0.3169 0.6502
Schistosoma mansoni ferritin 0.0017 0.0025 0.0029
Schistosoma mansoni alpha glucosidase 0.0038 0.0155 0.018
Loa Loa (eye worm) glutathione reductase 0.0146 0.0832 0.1706
Schistosoma mansoni hypothetical protein 0.0036 0.0139 0.0162
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0063 0.0314 0.0917
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0057 0.0274 0.0801
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0618 0.3803 0.7803
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0018 0.0031 0.0091
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0208 0.0208
Loa Loa (eye worm) hypothetical protein 0.015 0.0857 0.176
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0158 0.0909 0.3452
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0031 0.0064
Brugia malayi ImpB/MucB/SamB family protein 0.0047 0.0212 0.0435
Brugia malayi latrophilin 2 splice variant baaae 0.0102 0.056 0.1148
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.005 0.0233 0.0681
Brugia malayi Calcitonin receptor-like protein seb-1 0.015 0.0857 0.176
Echinococcus multilocularis caspase 0.0137 0.0776 0.0776
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0018 0.0031 0.0036
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0037 0.0149 0.0306
Echinococcus multilocularis RUN 0.002 0.0042 0.0042
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0047 0.0214 0.0224
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0067 0.0335 0.1274
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0208 0.0242
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0031 0.0064
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0014 0.0005 0.001
Trichomonas vaginalis conserved hypothetical protein 0.0063 0.0314 0.0644
Loa Loa (eye worm) hypothetical protein 0.002 0.0042 0.0085
Loa Loa (eye worm) pigment dispersing factor receptor c 0.015 0.0857 0.176
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0043 0.0127
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.005 0.0233 0.0681
Trichomonas vaginalis glucosylceramidase, putative 0.0545 0.3344 0.6861
Onchocerca volvulus 0.0558 0.3423 1
Entamoeba histolytica hypothetical protein 0.0036 0.0139 0.0366
Trypanosoma cruzi DNA polymerase eta, putative 0.0047 0.0212 0.0619
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0369 0.2238 0.8504
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.0558 0.3423 0.3989
Echinococcus multilocularis lysine specific demethylase 5A 0.0063 0.0309 0.0309
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.005 0.0233 0.163
Trichomonas vaginalis glucosylceramidase, putative 0.0789 0.4874 1
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.005 0.0233 0.0244
Echinococcus granulosus glycogen synthase kinase 3 beta 0.0558 0.3423 0.3589
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0063 0.0314 0.0644
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.005 0.0233 0.0681
Echinococcus granulosus lysine specific demethylase 6a 0.0017 0.0021 0.0022
Brugia malayi jmjC domain containing protein 0.0017 0.0021 0.0042
Schistosoma mansoni ferritin light chain 0.0017 0.0025 0.0029
Echinococcus granulosus thioredoxin glutathione reductase 0.0146 0.0832 0.0872
Loa Loa (eye worm) hypothetical protein 0.0027 0.0087 0.0179
Plasmodium falciparum thioredoxin reductase 0.005 0.0233 0.0681
Trichomonas vaginalis ferritin, putative 0.0017 0.0025 0.0051
Brugia malayi intermediate filament protein 0.0027 0.0087 0.0179
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0018 0.0031 0.0091
Loa Loa (eye worm) hypothetical protein 0.0029 0.0098 0.02
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0063 0.0314 0.0917
Trypanosoma brucei unspecified product 0.002 0.0043 0.0127
Giardia lamblia Kinase, CMGC GSK 0.0558 0.3423 0.9003
Schistosoma mansoni inositol monophosphatase 0.0075 0.0384 0.0448
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0072 0.0211
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0241 0.1431 1
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0075 0.0384 0.0789
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.002 0.0043 0.0127
Schistosoma mansoni caspase-3 (C14 family) 0.0137 0.0776 0.0904
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0332 0.2005 0.2102
Echinococcus multilocularis protein kinase shaggy 0.0558 0.3423 0.3423
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0063 0.0309 0.0309
Trichomonas vaginalis glucosylceramidase, putative 0.0518 0.3169 0.6502
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0063 0.013
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.002 0.0043 0.0046
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.005 0.0233 0.0681
Echinococcus granulosus dna polymerase eta 0.0047 0.0212 0.0222
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0014 0.0005 0.0014
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.005 0.0233 0.0681
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0043 0.0127
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0042 0.0042
Entamoeba histolytica hypothetical protein 0.0023 0.0063 0.0166
Trichomonas vaginalis CMGC family protein kinase 0.0558 0.3423 0.7025
Entamoeba histolytica hypothetical protein 0.0025 0.0074 0.0195
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0018 0.0031 0.0091
Trichomonas vaginalis CMGC family protein kinase 0.0057 0.0274 0.0563
Loa Loa (eye worm) jmjC domain-containing protein 0.0017 0.0021 0.0042
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.0558 0.3423 1
Schistosoma mansoni hypothetical protein 0.0047 0.0214 0.0249
Brugia malayi Thioredoxin reductase 0.0146 0.0832 0.1706
Echinococcus granulosus microtubule associated protein 2 0.1379 0.8582 0.8997
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0063 0.013
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0309 0.1857 0.3811
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0789 0.4874 1
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0018 0.0031 0.0032
Giardia lamblia Fructose-bisphosphate aldolase 0.0618 0.3803 1
Loa Loa (eye worm) hypothetical protein 0.0047 0.0214 0.0439
Entamoeba histolytica hypothetical protein 0.0036 0.0139 0.0366
Leishmania major glycosyl hydrolase-like protein 0.0014 0.0005 0.0014
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0047 0.0214 0.0439
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0043 0.0046
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0031 0.0064
Leishmania major phosphatidylinositol 3-kinase, putative 0.0018 0.0031 0.0091
Echinococcus granulosus dnaJ subfamily B 0.041 0.2496 0.2616
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.005 0.0233 0.0681
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0043 0.0127
Trypanosoma brucei glycosyl hydrolase-like protein 0.0014 0.0005 0.0014
Trichomonas vaginalis CMGC family protein kinase 0.0057 0.0274 0.0563
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.002 0.0043 0.0046
Loa Loa (eye worm) hypothetical protein 0.0017 0.0021 0.0042
Schistosoma mansoni aldehyde dehydrogenase 0.0125 0.0698 0.0814
Leishmania major phosphatidylinositol kinase related protein, putative 0.0018 0.0031 0.0092
Loa Loa (eye worm) inositol-1 0.0075 0.0384 0.0789
Echinococcus multilocularis cpg binding protein 0.003 0.0107 0.0107
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.015 0.0857 0.176
Trichomonas vaginalis glucosylceramidase, putative 0.0789 0.4874 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0031 0.0064
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.005 0.0145
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0241 0.1431 0.3762
Toxoplasma gondii aldehyde dehydrogenase 0.0125 0.0698 0.204
Trypanosoma cruzi metacaspase 5, putative 0.0063 0.0314 0.0917
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.005 0.0145
Echinococcus granulosus geminin 0.1031 0.6398 0.6707
Mycobacterium leprae PROBABLE BACTERIOFERRITIN BFRA 0.0017 0.0025 0.0095
Schistosoma mansoni lamin 0.0027 0.0087 0.0101
Brugia malayi glutathione reductase 0.0146 0.0832 0.1706
Onchocerca volvulus 0.0027 0.0087 0.0254
Plasmodium falciparum glutathione reductase 0.005 0.0233 0.0681
Trichomonas vaginalis DNA polymerase eta, putative 0.002 0.0043 0.0089
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0208 0.0218
Entamoeba histolytica deoxycytidyl transferase, putative 0.002 0.0043 0.0114
Echinococcus multilocularis lysosomal alpha glucosidase 0.0171 0.0993 0.0993
Schistosoma mansoni terminal deoxycytidyl transferase 0.002 0.0043 0.0051
Schistosoma mansoni inositol monophosphatase 0.0075 0.0384 0.0448
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0075 0.0384 0.2686
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.0137 0.0776 0.0776
Echinococcus multilocularis microtubule associated protein 2 0.1379 0.8582 0.8582
Loa Loa (eye worm) hypothetical protein 0.0017 0.0021 0.0042
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0031 0.0064
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0087 0.0179
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0031 0.0064
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0075 0.0384 0.1011
Plasmodium falciparum metacaspase-like protein 0.0063 0.0314 0.0917
Brugia malayi Inositol-1 0.0075 0.0384 0.0789
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.0558 0.3423 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0618 0.3803 0.7803
Loa Loa (eye worm) phosphatidylinositol 3 0.0018 0.0031 0.0064
Trypanosoma brucei metacaspase 5, putative 0.0063 0.0314 0.0917
Trichomonas vaginalis maltase-glucoamylase, putative 0.0038 0.0155 0.0318
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0043 0.0127
Brugia malayi Glycosyl hydrolases family 31 protein 0.0038 0.0155 0.0318
Echinococcus granulosus snurportin 1 0.0309 0.1857 0.1947
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.005 0.013
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0043 0.0046
Treponema pallidum bacterioferrin (TpF1) 0.0017 0.0025 0.0066
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0047 0.0214 0.0214
Brugia malayi hypothetical protein 0.002 0.0042 0.0085
Entamoeba histolytica protein kinase domain containing protein 0.0558 0.3423 0.9003
Trichomonas vaginalis glucosylceramidase, putative 0.0518 0.3169 0.6502
Leishmania major DNA polymerase eta, putative 0.0047 0.0212 0.0619
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0208 0.0242
Schistosoma mansoni jumonji domain containing protein 0.0017 0.0021 0.0024
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0004 0.0011
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0047 0.0214 0.0214
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0332 0.2005 0.7618
Schistosoma mansoni caspase-7 (C14 family) 0.0137 0.0776 0.0904
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0057 0.0274 0.0801
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0043 0.0127
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0618 0.3803 1
Echinococcus multilocularis geminin 0.1031 0.6398 0.6398
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.005 0.0052
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0017 0.0021 0.006
Loa Loa (eye worm) hypothetical protein 0.002 0.0042 0.0085
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0031 0.0064
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0031 0.0064
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0618 0.3803 0.7803
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0038 0.0155 0.0318
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0031 0.0064
Onchocerca volvulus Uncharacterized family 31 glucosidase KIAA1161 homolog 0.0014 0.0005 0.0014
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0125 0.0698 0.0732
Leishmania major GTP-binding protein, putative 0.0021 0.005 0.0145
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0241 0.1431 0.4179
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0057 0.0274 0.0801
Schistosoma mansoni phd/f-box containing protein 0.0017 0.0021 0.0024
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0618 0.3803 0.7803
Schistosoma mansoni hypothetical protein 0.0085 0.045 0.0524
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0017 0.0021 0.006
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0155 0.0452
Echinococcus granulosus JmjC domain containing protein 4 0.0017 0.0021 0.0022
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0031 0.0064
Echinococcus granulosus neuropeptide receptor A26 0.0469 0.2865 0.3004
Trichomonas vaginalis CMGC family protein kinase 0.0558 0.3423 0.7025
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0171 0.0993 0.2038
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0018 0.0031 0.0091
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0018 0.0031 0.0033
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0018 0.0031 0.0082
Loa Loa (eye worm) jmjC domain-containing protein 0.0017 0.0021 0.0042
Trypanosoma brucei unspecified product 0.0014 0.0004 0.0011
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0031 0.0064
Trichomonas vaginalis glucosylceramidase, putative 0.0545 0.3344 0.6861
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0014 0.0005 0.0013
Mycobacterium tuberculosis Probable oxidoreductase 0.0369 0.2238 0.2346
Schistosoma mansoni hypothetical protein 0.1031 0.6398 0.7455
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0043 0.0127
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.005 0.0233 0.0681
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0031 0.0064
Echinococcus granulosus apoptotic protease activating factor 1 0.0085 0.045 0.0472
Trichomonas vaginalis glucosylceramidase, putative 0.0518 0.3169 0.6502
Mycobacterium ulcerans flavoprotein disulfide reductase 0.005 0.0233 0.0244
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0063 0.013
Trypanosoma cruzi metacaspase, putative 0.0063 0.0314 0.0917
Trichomonas vaginalis conserved hypothetical protein 0.0063 0.0314 0.0644
Plasmodium falciparum JmjC domain-containing protein, putative 0.0017 0.0021 0.006
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0155 0.0318
Trichomonas vaginalis conserved hypothetical protein 0.0063 0.0314 0.0644
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.005 0.0233 0.0681
Plasmodium falciparum LCCL domain-containing protein 0.002 0.0042 0.0121
Schistosoma mansoni ran 0.0021 0.005 0.0058
Echinococcus multilocularis inositol monophosphatase 1 0.0075 0.0384 0.0384
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0057 0.0274 0.0801
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0008 0.0015
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0332 0.2005 0.2102
Loa Loa (eye worm) jmjC domain-containing protein 0.0017 0.0021 0.0042
Leishmania major dihydrolipoamide dehydrogenase, putative 0.005 0.0233 0.0681
Brugia malayi jmjC domain containing protein 0.0017 0.0021 0.0042
Plasmodium vivax glutathione reductase, putative 0.0146 0.0832 0.2429
Trypanosoma cruzi metacaspase 5, putative 0.0063 0.0314 0.0917
Plasmodium vivax metacaspase 1, putative 0.0063 0.0314 0.0917
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.005 0.0102
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0067 0.0335 0.0351
Echinococcus multilocularis JmjC domain containing protein 4 0.0017 0.0021 0.0021
Trichomonas vaginalis glucosylceramidase, putative 0.0518 0.3169 0.6502
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0063 0.0185
Schistosoma mansoni ran 0.0021 0.005 0.0058
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0043 0.0127
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.0005 0.001
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0789 0.4874 1
Echinococcus granulosus caspase 3 0.0073 0.0378 0.0396
Onchocerca volvulus 0.0027 0.0087 0.0254
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0075 0.0384 0.1123
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0057 0.0274 0.0563
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.005 0.0233 0.0681
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0618 0.3803 0.7803
Schistosoma mansoni hypothetical protein 0.041 0.2496 0.2908
Echinococcus multilocularis phd:f box containing protein 0.0017 0.0021 0.0021
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0618 0.3803 0.7803
Trichomonas vaginalis glucosylceramidase, putative 0.0789 0.4874 1
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0043 0.0127
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0075 0.0384 0.1123
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0046 0.0208 0.0426
Schistosoma mansoni phosphatidylserine receptor 0.0017 0.0021 0.0024
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0066 0.033 0.0346
Trypanosoma brucei glucosidase, putative 0.0038 0.0155 0.0452
Schistosoma mansoni serine/threonine protein kinase 0.0057 0.0274 0.032
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0025 0.0074 0.0217
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0018 0.0031 0.0064
Brugia malayi Muscleblind-like protein 0.0302 0.1813 0.3719
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0241 0.1431 0.15
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.005 0.0145
Schistosoma mansoni lipoxygenase 0.002 0.0042 0.0048
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0031 0.0064
Schistosoma mansoni hypothetical protein 0.0047 0.0214 0.0249
Trichomonas vaginalis maltase-glucoamylase, putative 0.0014 0.0005 0.001
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.005 0.0233 0.0681
Echinococcus multilocularis lamin dm0 0.0027 0.0087 0.0087
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0031 0.0064
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.005 0.0233 0.0244
Loa Loa (eye worm) hypothetical protein 0.0302 0.1813 0.3719
Echinococcus multilocularis dna polymerase kappa 0.002 0.0043 0.0043

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 8 uM Inhibition of human TP purified from placenta ChEMBL. 16337119
IC50 (binding) = 8.3 uM Inhibition of human TP expressed in V79 cells ChEMBL. 16337119
IC50 (binding) = 10.4 uM Inhibition of Escherichia coli TP ChEMBL. 16337119

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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