Detailed information for compound 1036529

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 319.765 | Formula: C11H14ClN3O4S
  • H donors: 1 H acceptors: 3 LogP: 1.19 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: NS(=O)(=O)OCCOc1cccc(c1)n1cncc1.Cl
  • InChi: 1S/C11H13N3O4S.ClH/c12-19(15,16)18-7-6-17-11-3-1-2-10(8-11)14-5-4-13-9-14;/h1-5,8-9H,6-7H2,(H2,12,15,16);1H
  • InChiKey: UZHUKLOQJIOVRC-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Bos taurus Carbonic anhydrase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Echinococcus granulosus carbonic anhydrase Carbonic anhydrase   312 aa 304 aa 29.6 %
Echinococcus multilocularis carbonic anhydrase Carbonic anhydrase   312 aa 259 aa 30.1 %
Schistosoma japonicum ko:K01672 carbonic anhydrase [EC4.2.1.1], putative Carbonic anhydrase   312 aa 253 aa 26.9 %
Brugia malayi Carbonic anhydrase like protein 2 precursor Carbonic anhydrase   312 aa 268 aa 24.6 %
Leishmania braziliensis carbonic anhydrase-like protein Carbonic anhydrase   312 aa 277 aa 25.6 %
Loa Loa (eye worm) hypothetical protein Carbonic anhydrase   312 aa 268 aa 25.4 %
Trypanosoma cruzi carbonic anhydrase-like protein, putative Carbonic anhydrase   312 aa 264 aa 25.4 %
Leishmania mexicana carbonic anhydrase-like protein Carbonic anhydrase   312 aa 287 aa 26.8 %
Onchocerca volvulus Carbonic anhydrase   312 aa 252 aa 23.4 %
Schistosoma mansoni carbonic anhydrase-related Carbonic anhydrase   312 aa 265 aa 26.0 %
Leishmania infantum carbonic anhydrase-like protein Carbonic anhydrase   312 aa 277 aa 26.7 %
Schistosoma mansoni carbonic anhydrase-related Carbonic anhydrase   312 aa 264 aa 24.2 %
Schistosoma japonicum ko:K01672 carbonic anhydrase [EC4.2.1.1], putative Carbonic anhydrase   312 aa 322 aa 28.3 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0014 0.0065 0.021
Brugia malayi Nuclear hormone receptor E75 0.0014 0.0065 0.021
Onchocerca volvulus 0.0018 0.012 0.0533
Schistosoma mansoni nAChR subunit 0.0018 0.012 0.0221
Loa Loa (eye worm) hypothetical protein 0.001 0.0014 0.0044
Onchocerca volvulus Serine\/threonine kinase homolog 0.0109 0.1249 0.6213
Loa Loa (eye worm) hypothetical protein 0.0018 0.012 0.0385
Schistosoma mansoni hypothetical protein 0.0036 0.0338 0.0677
Onchocerca volvulus 0.0018 0.012 0.0533
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0014 0.0065 0.021
Trypanosoma cruzi transcription factor btf3, putative 0.0069 0.0746 0.5854
Brugia malayi CXXC zinc finger family protein 0.0028 0.0235 0.0756
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0018 0.012 0.0221
Schistosoma mansoni hypothetical protein 0.0034 0.0308 0.0613
Loa Loa (eye worm) hypothetical protein 0.0123 0.1417 0.4558
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0018 0.012 0.0221
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.044 0.0427
Schistosoma mansoni carbonic anhydrase-related 0.0034 0.0308 0.0613
Echinococcus granulosus transcription factor btf3 0.0069 0.0746 0.1528
Schistosoma mansoni nAChR subunit 0.0018 0.012 0.0221
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0338 0.0325
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.003 0.0262 0.0842
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0235 0.0756
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0018 0.012 0.0385
Schistosoma mansoni hypothetical protein 0.0047 0.047 0.0952
Onchocerca volvulus Protein ultraspiracle homolog 0.003 0.0262 0.1248
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0018 0.012 0.0106
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0018 0.012 0.0385
Trypanosoma cruzi cytochrome P450, putative 0.0021 0.0156 0.0992
Entamoeba histolytica hypothetical protein 0.0036 0.0338 0.0935
Brugia malayi MH2 domain containing protein 0.0016 0.0089 0.0286
Schistosoma mansoni hypothetical protein 0.0047 0.047 0.0952
Schistosoma mansoni hypothetical protein 0.0041 0.0398 0.0801
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0034 0.0308 0.0613
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0018 0.012 0.0385
Brugia malayi nuclear hormone receptor 0.0014 0.0065 0.021
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0018 0.012 0.0385
Brugia malayi Calcitonin receptor-like protein seb-1 0.0147 0.1724 0.5545
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0018 0.012 0.0106
Echinococcus granulosus Nuclear hormone receptor HR96 0.0014 0.0065 0.0108
Trichomonas vaginalis glucosylceramidase, putative 0.017 0.2002 0.5581
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.003 0.0262 0.0248
Echinococcus granulosus Serine:threonine protein kinase PLK4 0.0254 0.3049 0.6331
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0018 0.012 0.0106
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.003 0.0262 0.0842
Loa Loa (eye worm) hypothetical protein 0.001 0.0014 0.0044
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0018 0.012 0.0385
Brugia malayi nuclear receptor NHR-88 0.003 0.0262 0.0842
Onchocerca volvulus Huntingtin homolog 0.0123 0.1417 0.7058
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0026 0.022 0.1515
Loa Loa (eye worm) hypothetical protein 0.0016 0.0086 0.0278
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.0026 0.022 0.0206
Echinococcus multilocularis ecdysone induced protein 78C 0.003 0.0262 0.0248
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0026 0.022 0.0273
Brugia malayi Nuclear hormone receptor E75 0.0014 0.0065 0.021
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0018 0.012 0.0385
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0026 0.022 0.0273
Brugia malayi MH2 domain containing protein 0.0016 0.0089 0.0286
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0026 0.022 0.0273
Schistosoma mansoni carbonic anhydrase-related 0.0034 0.0308 0.0613
Toxoplasma gondii hypothetical protein 0.0019 0.0128 0.1295
Loa Loa (eye worm) hypothetical protein 0.0016 0.0086 0.0278
Echinococcus granulosus TGF beta signal transducer SmadC 0.0016 0.0089 0.0157
Echinococcus multilocularis FTZ F1 alpha 0.003 0.0262 0.0248
Loa Loa (eye worm) cytochrome P450 family protein 0.0054 0.056 0.1801
Trypanosoma cruzi transcription factor btf3, putative 0.0069 0.0746 0.5854
Brugia malayi nuclear receptor RXR 0.0016 0.0086 0.0278
Echinococcus granulosus nuclear receptor 2DBD gamma 0.003 0.0262 0.0517
Brugia malayi MH1 domain containing protein 0.0016 0.0089 0.0286
Loa Loa (eye worm) carbonic anhydrase 3 0.0034 0.0308 0.0989
Loa Loa (eye worm) hypothetical protein 0.0014 0.0065 0.021
Toxoplasma gondii GAF domain-containing protein 0.0019 0.0128 0.1295
Brugia malayi CHE-14 protein 0.0042 0.0417 0.134
Loa Loa (eye worm) hypothetical protein 0.003 0.0262 0.0842
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0054 0.0557 0.1791
Brugia malayi Nuclear hormone receptor family member nhr-40 0.003 0.0262 0.0842
Loa Loa (eye worm) latrophilin receptor protein 2 0.0047 0.047 0.1512
Echinococcus granulosus carbonic anhydrase 0.0034 0.0308 0.0613
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0259 0.311 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.012 0.0385
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0018 0.012 0.0385
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0417 0.086
Brugia malayi Nuclear hormone receptor family member nhr-19 0.003 0.0262 0.0842
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0026 0.022 0.0273
Brugia malayi beta-NAC-like protein 0.0069 0.0746 0.2399
Loa Loa (eye worm) hypothetical protein 0.0209 0.2489 0.8003
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0018 0.012 0.0106
Schistosoma mansoni cpg binding protein 0.0029 0.0255 0.0503
Trichomonas vaginalis glucosylceramidase, putative 0.0259 0.311 0.8876
Echinococcus granulosus nAChR subunit 0.0018 0.012 0.0221
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.0026 0.022 0.043
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0109 0.1249 0.1237
Loa Loa (eye worm) MH2 domain-containing protein 0.0016 0.0089 0.0286
Echinococcus granulosus Protein patched homolog 1 0.0042 0.0417 0.084
Brugia malayi nuclear hormone receptor 0.003 0.0262 0.0842
Schistosoma mansoni serine/threonine protein kinase 0.0109 0.1249 0.2577
Toxoplasma gondii hypothetical protein 0.0019 0.0128 0.1295
Loa Loa (eye worm) ICD-1 protein 0.0069 0.0746 0.2399
Echinococcus granulosus nuclear receptor nhr 48 0.0014 0.0065 0.0108
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.003 0.0262 0.0517
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0014 0.0065 0.0052
Brugia malayi conserved hypotetical protein 0.0014 0.0065 0.021
Brugia malayi Cation transporter family protein 0.0018 0.012 0.0385
Trichomonas vaginalis glucosylceramidase, putative 0.017 0.2002 0.5581
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0026 0.022 0.0273
Trypanosoma brucei carbonic anhydrase-like protein 0.0034 0.0308 0.224
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0141 0.1647 1
Loa Loa (eye worm) hypothetical protein 0.0047 0.047 0.1512
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0057 0.0605 0.3533
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0018 0.012 0.0385
Trichomonas vaginalis CAMK family protein kinase 0.0109 0.1249 0.3339
Loa Loa (eye worm) LGC-31 protein 0.0018 0.012 0.0385
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0047 0.047 0.0952
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0057 0.0605 0.0592
Brugia malayi hypothetical protein 0.0014 0.0065 0.021
Loa Loa (eye worm) hypothetical protein 0.0018 0.012 0.0385
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0026 0.022 0.1515
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0018 0.012 0.0385
Echinococcus granulosus glycine receptor subunit alpha 1 0.0018 0.012 0.0221
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0109 0.1249 0.4018
Schistosoma mansoni nuclear receptor 0.0014 0.0065 0.0108
Loa Loa (eye worm) hypothetical protein 0.0018 0.012 0.0385
Loa Loa (eye worm) hypothetical protein 0.0018 0.012 0.0385
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0018 0.012 0.0221
Echinococcus multilocularis carbonic anhydrase II 0.0034 0.0308 0.0294
Toxoplasma gondii hypothetical protein 0.0019 0.0128 0.1295
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.044 0.0889
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0289 0.3487 1
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0026 0.022 0.0273
Brugia malayi Cation transporter family protein 0.0018 0.012 0.0385
Schistosoma mansoni hypothetical protein 0.0164 0.1927 0.3992
Brugia malayi Nuclear hormone receptor family member nhr-25 0.003 0.0262 0.0842
Loa Loa (eye worm) hypothetical protein 0.001 0.0014 0.0044
Loa Loa (eye worm) hypothetical protein 0.003 0.0262 0.0842
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.001 0.0014 0.0044
Trichomonas vaginalis CAMK family protein kinase 0.0109 0.1249 0.3339
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0034 0.0308 0.0989
Schistosoma mansoni nuclear hormone receptor 0.003 0.0262 0.0517
Loa Loa (eye worm) hypothetical protein 0.0014 0.0065 0.021
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0057 0.0605 0.1946
Loa Loa (eye worm) hypothetical protein 0.0147 0.1724 0.5545
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0026 0.022 0.1515
Loa Loa (eye worm) nuclear receptor NHR-67 0.0014 0.0065 0.021
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0018 0.012 0.0221
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0018 0.012 0.0106
Loa Loa (eye worm) hypothetical protein 0.0016 0.0086 0.0278
Loa Loa (eye worm) hypothetical protein 0.0018 0.012 0.0385
Entamoeba histolytica hypothetical protein 0.0069 0.0746 0.2109
Echinococcus multilocularis cpg binding protein 0.0029 0.0255 0.0242
Echinococcus granulosus retinoic acid receptor rxr beta a 0.003 0.0262 0.0517
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0026 0.022 0.0273
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.022 0.0273
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0014 0.0065 0.0052
Echinococcus granulosus dnaJ subfamily B 0.0395 0.4808 1
Brugia malayi hypothetical protein 0.0016 0.0086 0.0278
Loa Loa (eye worm) hypothetical protein 0.0014 0.0065 0.021
Brugia malayi Nuclear hormone receptor family member nhr-25 0.003 0.0262 0.0842
Echinococcus multilocularis expressed conserved protein 0.0093 0.1043 0.1031
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0018 0.012 0.0385
Plasmodium falciparum carbonic anhydrase 0.0034 0.0308 0.2907
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0014 0.0065 0.0108
Echinococcus granulosus glycine receptor subunit beta 0.0018 0.012 0.0221
Brugia malayi Nuclear hormone receptor family member nhr-19 0.003 0.0262 0.0842
Loa Loa (eye worm) hypothetical protein 0.0018 0.012 0.0385
Trichomonas vaginalis conserved hypothetical protein 0.0069 0.0746 0.1841
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0026 0.022 0.0273
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0026 0.022 0.0273
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0047 0.047 0.0457
Loa Loa (eye worm) steroid hormone receptor 0.003 0.0262 0.0842
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0014 0.0065 0.0052
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0034 0.0308 0.0989
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.0026 0.022 0.043
Entamoeba histolytica hypothetical protein 0.0036 0.0338 0.0935
Trichomonas vaginalis CAMK family protein kinase 0.0109 0.1249 0.3339
Loa Loa (eye worm) cytochrome P450 0.0012 0.0036 0.0115
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0047 0.047 0.1512
Onchocerca volvulus 0.0014 0.0065 0.026
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0018 0.012 0.0385
Schistosoma mansoni nAChR subunit 0.0018 0.012 0.0221
Echinococcus multilocularis nAChR subunit 0.0018 0.012 0.0106
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.044 0.0427
Echinococcus granulosus cpg binding protein 0.0029 0.0255 0.0503
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.0235 0.2818 0.585
Schistosoma mansoni cpg binding protein 0.0029 0.0255 0.0503
Echinococcus multilocularis protein dispatched 1 0.0048 0.0491 0.0478
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.0026 0.022 0.0273
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0018 0.012 0.0221
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0109 0.1249 0.2577
Echinococcus multilocularis Smad4 0.0016 0.0089 0.0076
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0109 0.1249 1
Echinococcus multilocularis Niemann Pick C1 protein 0.0099 0.1117 0.1105
Loa Loa (eye worm) MH1 domain-containing protein 0.0016 0.0089 0.0286
Echinococcus granulosus Nuclear hormone receptor HR96 0.0014 0.0065 0.0108
Brugia malayi excitatory GABA receptor EXP-1A 0.0018 0.012 0.0385
Loa Loa (eye worm) hypothetical protein 0.003 0.0262 0.0842
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0026 0.022 0.0273
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0026 0.022 0.0273
Brugia malayi Steroid receptor seven-up type 2 0.003 0.0262 0.0842
Schistosoma mansoni hypothetical protein 0.0047 0.047 0.0952
Loa Loa (eye worm) hypothetical protein 0.0014 0.0065 0.021
Loa Loa (eye worm) hypothetical protein 0.0018 0.012 0.0385
Echinococcus granulosus glycine receptor subunit beta 0.0018 0.012 0.0221
Trichomonas vaginalis glucosylceramidase, putative 0.017 0.2002 0.5581
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0016 0.0086 0.0073
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0026 0.022 0.1515
Onchocerca volvulus Putative nachr subunit 0.0018 0.012 0.0533
Schistosoma mansoni nAChR subunit 0.0018 0.012 0.0221
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0026 0.022 0.0273
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.044 0.0889
Mycobacterium ulcerans putative regulatory protein 0.0019 0.0128 0.0571
Schistosoma mansoni kinase 0.0362 0.44 0.9148
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0018 0.012 0.0221
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.003 0.0262 0.0517
Echinococcus granulosus glycine receptor subunit alpha 1 0.0018 0.012 0.0221
Echinococcus granulosus smad 0.0016 0.0089 0.0157
Schistosoma mansoni niemann-pick C1 (NPC1) 0.01 0.1136 0.2341
Brugia malayi steroid hormone receptor 0.003 0.0262 0.0842
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0018 0.012 0.0221
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0026 0.022 0.0706
Loa Loa (eye worm) hypothetical protein 0.0018 0.012 0.0385
Loa Loa (eye worm) hypothetical protein 0.0101 0.1144 0.3679
Mycobacterium ulcerans two component sensor histidine kinase DevS 0.0019 0.0128 0.0571
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0014 0.0065 0.0108
Loa Loa (eye worm) hypothetical protein 0.0026 0.022 0.0706
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0026 0.022 0.0273
Echinococcus multilocularis Serine:threonine protein kinase PLK4 0.0254 0.3049 0.304
Echinococcus multilocularis thyroid hormone receptor alpha 0.003 0.0262 0.0248
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0018 0.012 0.0385
Loa Loa (eye worm) hypothetical protein 0.001 0.0014 0.0044
Loa Loa (eye worm) GABA receptor subunit 0.001 0.0014 0.0044
Echinococcus granulosus carbonic anhydrase 0.0034 0.0308 0.0613
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.003 0.0262 0.1248
Brugia malayi nuclear receptor NHR-88 0.0014 0.0065 0.021
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0034 0.0308 0.0989
Echinococcus granulosus carbonic anhydrase 0.0034 0.0308 0.0613
Echinococcus granulosus Niemann Pick C1 protein 0.0099 0.1117 0.2302
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0034 0.0308 0.0989
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0034 0.0308 0.0989
Schistosoma mansoni nAChR subunit 0.0018 0.012 0.0221
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0026 0.022 0.0273
Brugia malayi Smad1 0.0016 0.0089 0.0286
Loa Loa (eye worm) ACC-1 protein 0.0018 0.012 0.0385
Loa Loa (eye worm) hypothetical protein 0.001 0.001 0.0033
Brugia malayi Cytochrome P450 family protein 0.0054 0.056 0.1801
Loa Loa (eye worm) hypothetical protein 0.0228 0.2727 0.8768
Entamoeba histolytica serine/threonine protein kinase, putative 0.0109 0.1249 0.3557
Onchocerca volvulus 0.003 0.0262 0.1248
Brugia malayi Nuclear hormone receptor family member nhr-31 0.003 0.0262 0.0842
Loa Loa (eye worm) nuclear hormone receptor 0.0014 0.0065 0.021
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.003 0.0262 0.0248
Loa Loa (eye worm) hypothetical protein 0.0018 0.012 0.0385
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.003 0.0262 0.0517
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0141 0.1647 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.0086 0.0278
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0018 0.012 0.0385
Brugia malayi photoreceptor-specific nuclear receptor 0.003 0.0262 0.0842
Echinococcus multilocularis transcription factor btf3 0.0069 0.0746 0.0734
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0016 0.0089 0.0157
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0018 0.012 0.0221
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0026 0.022 0.0273
Schistosoma mansoni Smad4 0.0016 0.0089 0.0157
Brugia malayi Nuclear hormone receptor family member nhr-41 0.003 0.0262 0.0842
Trichomonas vaginalis glucosylceramidase, putative 0.0179 0.2116 0.5919
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.003 0.0262 0.0842
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0034 0.0308 0.224
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0014 0.0065 0.026
Trypanosoma cruzi polo-like protein kinase, putative 0.0109 0.1249 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0289 0.3487 1
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0014 0.0065 0.021
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0026 0.022 0.0273
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0014 0.0065 0.0108
Echinococcus granulosus GPCR family 2 0.0047 0.047 0.0952
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0026 0.022 0.0273
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0057 0.0605 0.3533
Echinococcus multilocularis sterol regulatory element binding protein 0.0042 0.0417 0.0404
Loa Loa (eye worm) DR-78 0.0014 0.0065 0.021
Schistosoma mansoni nuclear hormone receptor 0.0014 0.0065 0.0108
Schistosoma mansoni hypothetical protein 0.0041 0.0398 0.0801
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0034 0.0308 0.0989
Brugia malayi Nuclear hormone receptor family member nhr-3 0.003 0.0262 0.0842
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0018 0.012 0.0221
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0026 0.022 0.0273
Schistosoma mansoni coup transcription factor 0.003 0.0262 0.0517
Loa Loa (eye worm) hypothetical protein 0.0018 0.012 0.0385
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0026 0.022 0.0273
Loa Loa (eye worm) hypothetical protein 0.001 0.0014 0.0044
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0018 0.012 0.0221
Schistosoma mansoni smad 0.0016 0.0089 0.0157
Loa Loa (eye worm) MH2 domain-containing protein 0.0235 0.2814 0.9049
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0018 0.012 0.0385
Loa Loa (eye worm) hypothetical protein 0.0018 0.012 0.0385
Onchocerca volvulus Glucosylceramidase homolog 0.017 0.2002 1
Echinococcus granulosus thyroid hormone receptor alpha 0.0014 0.0065 0.0108
Brugia malayi Nuclear hormone receptor-like 1 0.0016 0.0086 0.0278
Schistosoma mansoni zinc finger protein 0.0014 0.0065 0.0108
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0018 0.012 0.0221
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0289 0.3487 1
Schistosoma mansoni hypothetical protein 0.0047 0.047 0.0952
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.003 0.0262 0.0842
Brugia malayi Putative carbonic anhydrase 5 precursor 0.0034 0.0308 0.0989
Schistosoma mansoni carbonic anhydrase-related 0.0034 0.0308 0.0613
Trichomonas vaginalis conserved hypothetical protein 0.0069 0.0746 0.1841
Brugia malayi serine/threonine-protein kinase plk-2 0.0109 0.1249 0.4018
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0018 0.012 0.0385
Schistosoma mansoni hypothetical protein 0.0012 0.0036 0.0046
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.003 0.0262 0.0248
Schistosoma mansoni hypothetical protein 0.0395 0.4808 1
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0026 0.022 0.0273
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0018 0.012 0.0385
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0026 0.022 0.0273
Echinococcus multilocularis glycine receptor subunit beta 0.0018 0.012 0.0106
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.001 0.0014 0.0044
Trypanosoma cruzi cytochrome P450, putative 0.0021 0.0156 0.0992
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.003 0.0262 0.0517
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.003 0.0262 0.0842
Schistosoma mansoni retinoic acid receptor RXR 0.003 0.0262 0.0517
Onchocerca volvulus 0.0028 0.0235 0.1114
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0018 0.012 0.0385
Brugia malayi Cytochrome P450 family protein 0.0012 0.0036 0.0115
Echinococcus granulosus sterol regulatory element binding protein 0.0042 0.0417 0.084
Trichomonas vaginalis glucosylceramidase, putative 0.017 0.2002 0.5581
Echinococcus granulosus Smad4 0.0016 0.0089 0.0157
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0014 0.0065 0.0108
Trichomonas vaginalis glucosylceramidase, putative 0.017 0.2002 0.5581
Echinococcus granulosus mothers against decapentaplegic 5 0.0016 0.0089 0.0157
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.003 0.0262 0.0248
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0289 0.3487 1
Toxoplasma gondii NAC domain-containing protein 0.0069 0.0746 1
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0018 0.012 0.0106
Schistosoma mansoni RAR-like nuclear receptor 0.003 0.0262 0.0517
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0018 0.012 0.0106
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0289 0.3487 1
Echinococcus multilocularis carbonic anhydrase 0.0034 0.0308 0.0294
Schistosoma mansoni retinoid-x-receptor (RXR) 0.003 0.0262 0.0517
Brugia malayi ecdysone receptor 0.0014 0.0065 0.021
Loa Loa (eye worm) hypothetical protein 0.0014 0.0065 0.021
Schistosoma mansoni patched 1 0.0042 0.0417 0.084
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0057 0.0605 0.3533
Loa Loa (eye worm) hypothetical protein 0.001 0.0014 0.0044
Trichomonas vaginalis glucosylceramidase, putative 0.0259 0.311 0.8876
Toxoplasma gondii hypothetical protein 0.0034 0.0308 0.3826
Schistosoma mansoni steroid hormone receptor ad4bp 0.003 0.0262 0.0517
Schistosoma mansoni carbonic anhydrase 0.0034 0.0308 0.0613
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0026 0.022 0.0273
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.0026 0.022 0.043
Trypanosoma brucei transcription factor BTF3, putative 0.0069 0.0746 0.5854
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.003 0.0262 0.0248
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0289 0.3487 1
Schistosoma mansoni thyroid hormone receptor 0.003 0.0262 0.0517
Loa Loa (eye worm) hypothetical protein 0.0018 0.012 0.0385
Loa Loa (eye worm) hypothetical protein 0.0014 0.0065 0.021
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.044 0.0889
Schistosoma mansoni hypothetical protein 0.0164 0.1927 0.3992
Brugia malayi Latrophilin receptor protein 2 0.0047 0.047 0.1512
Entamoeba histolytica hypothetical protein 0.0036 0.0338 0.0935
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0018 0.012 0.0221
Echinococcus multilocularis 0.0012 0.0036 0.0022
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.003 0.0262 0.0517
Trypanosoma brucei polo-like protein kinase 0.0109 0.1249 1
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0026 0.022 0.0273
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0018 0.012 0.0385
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.003 0.0262 0.0842
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.0235 0.2818 0.9063
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.001 0.0014 0.0044
Brugia malayi latrophilin 2 splice variant baaae 0.0101 0.1144 0.3679
Loa Loa (eye worm) hypothetical protein 0.003 0.0262 0.0842
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0018 0.012 0.0385
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0044 0.044 0.1414
Trichomonas vaginalis glucosylceramidase, putative 0.0259 0.311 0.8876
Schistosoma mansoni cytochrome P450 0.0012 0.0036 0.0046
Trichomonas vaginalis glucosylceramidase, putative 0.0259 0.311 0.8876
Brugia malayi nuclear hormone receptor family member nhr-6 0.0014 0.0065 0.021
Schistosoma mansoni smad1 5 8 and 0.0016 0.0089 0.0157
Onchocerca volvulus 0.0018 0.012 0.0533
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0338 0.0677
Echinococcus multilocularis nuclear receptor nhr 48 0.0014 0.0065 0.0052
Echinococcus multilocularis protein patched 0.0042 0.0417 0.0404
Trichomonas vaginalis CAMK family protein kinase 0.0109 0.1249 0.3339
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0057 0.0605 0.4691
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0016 0.0086 0.0152
Echinococcus multilocularis carbonic anhydrase 0.0034 0.0308 0.0294
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0057 0.0605 0.1234
Onchocerca volvulus 0.0018 0.012 0.0533
Echinococcus granulosus expressed conserved protein 0.0093 0.1043 0.2147
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0059 0.0622 0.127
Treponema pallidum fructose-bisphosphate aldolase 0.0289 0.3487 0.5
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0026 0.022 0.0273
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0289 0.3487 1
Schistosoma mansoni nuclear hormone receptor 0.0014 0.0065 0.0108
Loa Loa (eye worm) hypothetical protein 0.0018 0.012 0.0385
Loa Loa (eye worm) hypothetical protein 0.0018 0.012 0.0385
Brugia malayi tailless protein 0.0014 0.0065 0.021
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.003 0.0262 0.0248
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0018 0.012 0.0385
Echinococcus multilocularis glycine receptor subunit beta 0.0018 0.012 0.0106
Schistosoma mansoni hypothetical protein 0.0041 0.0398 0.0801
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0018 0.012 0.0106
Mycobacterium leprae conserved hypothetical protein 0.0019 0.0128 0.0571
Loa Loa (eye worm) hypothetical protein 0.0042 0.0417 0.134
Loa Loa (eye worm) hypothetical protein 0.003 0.0262 0.0842
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0026 0.022 0.1515
Loa Loa (eye worm) cytochrome P450 family protein 0.0021 0.0156 0.0502
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0026 0.022 0.0273
Loa Loa (eye worm) hypothetical protein 0.0018 0.012 0.0385
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.0235 0.2818 0.2809
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0047 0.047 0.0457
Loa Loa (eye worm) CYP4Cod1 0.0021 0.0156 0.0502
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0016 0.0089 0.0076
Brugia malayi ecdysteroid receptor 0.003 0.0262 0.0842
Loa Loa (eye worm) hypothetical protein 0.0123 0.1417 0.4558
Brugia malayi Niemann-Pick C1 protein precursor 0.0099 0.1117 0.3593
Schistosoma mansoni thyroid hormone receptor 0.003 0.0262 0.0517
Trypanosoma cruzi polo-like protein kinase, putative 0.0109 0.1249 1
Schistosoma mansoni hypothetical protein 0.0101 0.1144 0.2357
Leishmania major cytochrome p450-like protein 0.0021 0.0156 0.0992
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0014 0.0065 0.026
Schistosoma mansoni Tr4/Tr2 (homologue) 0.003 0.0262 0.0517
Loa Loa (eye worm) Smad1 0.0016 0.0089 0.0286
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0014 0.0065 0.0052
Loa Loa (eye worm) hypothetical protein 0.001 0.0014 0.0044
Trichomonas vaginalis CAMK family protein kinase 0.0109 0.1249 0.3339
Onchocerca volvulus Huntingtin homolog 0.0123 0.1417 0.7058
Trichomonas vaginalis CAMK family protein kinase 0.0109 0.1249 0.3339
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.003 0.0262 0.0517
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0338 0.0677
Schistosoma mansoni nuclear receptor 0.0014 0.0065 0.0108
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0016 0.0086 0.0152
Entamoeba histolytica transcription factor BTF3, putative 0.0069 0.0746 0.2109
Leishmania major carbonic anhydrase-like protein 0.0034 0.0308 0.224
Echinococcus granulosus FTZ F1 alpha 0.003 0.0262 0.0517
Echinococcus multilocularis carbonic anhydrase 0.0034 0.0308 0.0294
Brugia malayi Cytochrome P450 family protein 0.0021 0.0156 0.0502
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0016 0.0086 0.0152
Schistosoma mansoni cpg binding protein 0.0028 0.0235 0.0462
Loa Loa (eye worm) hypothetical protein 0.0016 0.0086 0.0278
Brugia malayi nuclear hormone receptor family member odr-7 0.0014 0.0065 0.021
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0018 0.012 0.0221
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0147 0.1724 0.5545
Mycobacterium tuberculosis Two component sensor histidine kinase DosT 0.0019 0.0128 0.0571
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0018 0.012 0.0106
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0021 0.0156 0.0747
Loa Loa (eye worm) ACC-1 protein 0.0018 0.012 0.0385
Loa Loa (eye worm) hypothetical protein 0.0099 0.1117 0.3593
Echinococcus multilocularis GPCR, family 2 0.0047 0.047 0.0457
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0018 0.012 0.0221
Trichomonas vaginalis glucosylceramidase, putative 0.0259 0.311 0.8876
Brugia malayi hypothetical protein 0.0123 0.1417 0.4558
Trichomonas vaginalis glucosylceramidase, putative 0.017 0.2002 0.5581
Loa Loa (eye worm) hypothetical protein 0.0018 0.012 0.0385
Loa Loa (eye worm) hypothetical protein 0.0052 0.0535 0.1721
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0259 0.311 1
Toxoplasma gondii histone lysine methyltransferase SET1 0.0053 0.0544 0.7156
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0026 0.022 0.0273
Echinococcus granulosus ecdysone induced protein 78C 0.003 0.0262 0.0517
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0034 0.0308 0.0989
Plasmodium vivax basic transcription factor 3b, putative 0.0069 0.0746 1
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0042 0.0417 0.134
Brugia malayi Nuclear hormone receptor-like 1 0.003 0.0262 0.0842
Trichomonas vaginalis conserved hypothetical protein 0.0069 0.0746 0.1841
Echinococcus granulosus nuclear receptor 2DBD gamma 0.003 0.0262 0.0517
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0018 0.012 0.0106
Schistosoma mansoni nAChR subunit 0.0018 0.012 0.0221
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.044 0.0889
Schistosoma mansoni transcription factor btf3 0.0069 0.0746 0.1528
Brugia malayi Cytochrome P450 family protein 0.0021 0.0156 0.0502
Schistosoma mansoni nuclear receptor nhr-48 0.0014 0.0065 0.0108
Entamoeba histolytica hypothetical protein 0.0036 0.0338 0.0935
Brugia malayi hypothetical protein 0.0014 0.0065 0.021
Brugia malayi hypothetical protein 0.0036 0.0338 0.1088
Loa Loa (eye worm) hypothetical protein 0.0018 0.012 0.0385
Loa Loa (eye worm) hypothetical protein 0.0034 0.0308 0.0989
Echinococcus granulosus cytochrome P450 2K1 0.0012 0.0036 0.0046
Brugia malayi MH1 domain containing protein 0.0016 0.0089 0.0286
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0057 0.0605 0.1234
Brugia malayi hypothetical protein 0.0016 0.0086 0.0278
Leishmania major basic transcription factor 3a, putative 0.0069 0.0746 0.5854
Echinococcus granulosus geminin 0.0164 0.1927 0.3992
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.003 0.0262 0.0842
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0147 0.1724 0.5545
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0034 0.0308 0.224
Brugia malayi cytochrome P450 0.0012 0.0036 0.0115
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0026 0.022 0.0273
Schistosoma mansoni smad1 5 8 and 0.0016 0.0089 0.0157
Loa Loa (eye worm) hypothetical protein 0.0034 0.0308 0.0989
Loa Loa (eye worm) hypothetical protein 0.0014 0.0065 0.021
Loa Loa (eye worm) cytochrome P450 family protein 0.0021 0.0156 0.0502
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.003 0.0262 0.0842
Echinococcus granulosus glycine receptor subunit alpha 1 0.0018 0.012 0.0221
Onchocerca volvulus 0.0018 0.012 0.0533
Loa Loa (eye worm) hypothetical protein 0.0018 0.012 0.0385
Onchocerca volvulus Bile acid receptor homolog 0.003 0.0262 0.1248
Brugia malayi Nuclear hormone receptor family member nhr-1 0.003 0.0262 0.0842
Trichomonas vaginalis glucosylceramidase, putative 0.017 0.2002 0.5581
Loa Loa (eye worm) hypothetical protein 0.003 0.0262 0.0842
Trichomonas vaginalis glucosylceramidase, putative 0.0259 0.311 0.8876
Giardia lamblia Fructose-bisphosphate aldolase 0.0289 0.3487 1
Brugia malayi Cation transporter family protein 0.0018 0.012 0.0385
Schistosoma mansoni nAChR subunit 0.0018 0.012 0.0221
Brugia malayi nuclear receptor NHR-67 0.0014 0.0065 0.021
Mycobacterium tuberculosis Two component sensor histidine kinase DevS 0.0019 0.0128 0.0571
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0289 0.3487 1
Echinococcus multilocularis dnaJ subfamily B 0.0395 0.4808 0.4801
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0026 0.022 0.0273
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0289 0.3487 1
Echinococcus granulosus carbonic anhydrase II 0.0034 0.0308 0.0613
Schistosoma mansoni hypothetical protein 0.0041 0.0398 0.0801
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.003 0.0262 0.0517
Loa Loa (eye worm) hypothetical protein 0.003 0.0262 0.0842
Brugia malayi MH2 domain containing protein 0.0235 0.2814 0.9049
Loa Loa (eye worm) hypothetical protein 0.001 0.0014 0.0044
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0018 0.012 0.0385
Onchocerca volvulus 0.0014 0.0065 0.026
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0026 0.022 0.0273
Trichomonas vaginalis CAMK family protein kinase 0.0109 0.1249 0.3339
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0047 0.047 0.0952
Loa Loa (eye worm) hypothetical protein 0.0014 0.0065 0.021
Onchocerca volvulus 0.0018 0.012 0.0533
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0099 0.1117 0.3177
Echinococcus multilocularis Niemann Pick C1 protein 0.0141 0.1644 0.1633
Brugia malayi nuclear receptor RXR 0.0014 0.0065 0.021
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.001 0.0014 0.0044
Echinococcus multilocularis smad 0.0016 0.0089 0.0076
Brugia malayi Nuclear hormone receptor family member nhr-14 0.003 0.0262 0.0842
Echinococcus granulosus Niemann Pick C1 protein 0.0141 0.1644 0.34
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0014 0.0065 0.0052
Loa Loa (eye worm) hypothetical protein 0.0014 0.0065 0.021
Loa Loa (eye worm) hypothetical protein 0.001 0.0014 0.0044
Trichomonas vaginalis glucosylceramidase, putative 0.0179 0.2116 0.5919
Loa Loa (eye worm) hypothetical protein 0.0014 0.0065 0.021
Mycobacterium ulcerans putative regulatory protein 0.0019 0.0128 0.0571
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0018 0.012 0.0385
Echinococcus multilocularis geminin 0.0164 0.1927 0.1916
Brugia malayi orphan nuclear receptor NR2E1 0.0014 0.0065 0.021
Brugia malayi Nuclear hormone receptor-like 1 0.0016 0.0086 0.0278
Brugia malayi Nuclear hormone receptor family member nhr-49 0.003 0.0262 0.0842
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.003 0.0262 0.0842
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0016 0.0086 0.0278
Loa Loa (eye worm) transcription factor SMAD2 0.0235 0.2814 0.9049
Loa Loa (eye worm) hypothetical protein 0.0014 0.0065 0.021
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.044 0.0889
Loa Loa (eye worm) hypothetical protein 0.0034 0.0308 0.0989
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0141 0.1647 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.0065 0.021
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.003 0.0262 0.0517
Trypanosoma brucei cytochrome P450, putative 0.0021 0.0156 0.0992
Schistosoma mansoni smad1 5 8 and 0.0016 0.0089 0.0157
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0289 0.3487 1
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0034 0.0308 0.0613
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0026 0.022 0.0273
Plasmodium falciparum basic transcription factor 3b, putative 0.0069 0.0746 1
Loa Loa (eye worm) hypothetical protein 0.003 0.0262 0.0842
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0034 0.0308 0.0989
Echinococcus multilocularis mothers against decapentaplegic 5 0.0016 0.0089 0.0076
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0044 0.044 0.1414

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 0.000000069 M Bovine erythrocyte carbonic anhydrase inhibitory activity of the compound. ChEMBL. 1479580

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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