Detailed information for compound 1038334

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 366.174 | Formula: C16H10Cl2FN3O2
  • H donors: 2 H acceptors: 2 LogP: 4.01 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(Cc1ccc(cc1)F)N/N=C/1\C(=O)Nc2c1c(Cl)c(cc2)Cl
  • InChi: 1S/C16H10Cl2FN3O2/c17-10-5-6-11-13(14(10)18)15(16(24)20-11)22-21-12(23)7-8-1-3-9(19)4-2-8/h1-6H,7H2,(H,21,23)(H,20,22,24)
  • InChiKey: DWDZKQOXYJXSEB-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens MET proto-oncogene, receptor tyrosine kinase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major cytochrome p450-like protein 0.0064 0.1167 1
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0064 0.1167 0.8763
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0064 0.1167 0.8763
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.1115 0.4544
Trypanosoma cruzi cytochrome P450, putative 0.0064 0.1167 1
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0064 0.1167 0.8763
Mycobacterium leprae Conserved hypothetical protein 0.0064 0.1167 1
Schistosoma mansoni glucose transport protein 0.0105 0.2128 0.8835
Loa Loa (eye worm) hypothetical protein 0.0015 0.0042 0.006
Onchocerca volvulus 0.002 0.0153 0.086
Schistosoma mansoni glucose transport protein 0.0105 0.2128 0.8835
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0032 0.0444 0.1703
Leishmania major glucose transporter, lmgt2 0.0033 0.0454 0.3657
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0272 0.11
Leishmania major protein kinase, putative 0.0032 0.0444 0.3573
Loa Loa (eye worm) cytochrome P450 0.0064 0.1167 0.1652
Loa Loa (eye worm) sugar transporter 0.0105 0.2128 0.3011
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0064 0.1167 1
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0064 0.1167 1
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0105 0.2128 0.8835
Loa Loa (eye worm) hypothetical protein 0.0015 0.0042 0.006
Schistosoma mansoni rab6-interacting 0.002 0.0153 0.0468
Onchocerca volvulus 0.002 0.0153 0.086
Toxoplasma gondii facilitative glucose transporter GT1 0.0105 0.2128 0.3201
Loa Loa (eye worm) hypothetical protein 0.0015 0.0042 0.006
Trypanosoma brucei THT1 - hexose transporter, putative 0.0033 0.0454 0.3657
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0064 0.1167 1
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0061 0.1115 0.9534
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0064 0.1167 0.8763
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0061 0.1115 0.9534
Brugia malayi Plexin repeat family protein 0.0021 0.0181 0.0198
Plasmodium falciparum calcium-dependent protein kinase 4 0.0032 0.0445 0.0404
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0025 0.0272 0.11
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0025 0.0272 0.2039
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0032 0.0444 0.3573
Loa Loa (eye worm) doublecortin family protein 0.002 0.0153 0.0216
Brugia malayi hypoxia-induced factor 1 0.0295 0.6495 0.9188
Onchocerca volvulus 0.0071 0.1326 1
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0064 0.1167 0.8763
Toxoplasma gondii lysine-tRNA ligase 0.0024 0.0243 0.0308
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0064 0.1167 0.8763
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0064 0.1167 1
Plasmodium falciparum mitogen-activated protein kinase 2 0.017 0.3622 0.3595
Loa Loa (eye worm) CYP4Cod1 0.0064 0.1167 0.1652
Schistosoma mansoni loxhd1 0.002 0.0153 0.0468
Trichomonas vaginalis glucose transporter, putative 0.0033 0.0454 0.1973
Echinococcus multilocularis calcium dependent protein kinase 0.003 0.0398 0.1508
Trypanosoma brucei THT1 - hexose transporter, putative 0.0033 0.0454 0.3657
Trichomonas vaginalis guanylate cyclase, putative 0.0025 0.0272 0.11
Trichomonas vaginalis guanylate cyclase, putative 0.0025 0.0272 0.11
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.1115 0.8355
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0117 0.2403 1
Trypanosoma brucei glucose transporter, putative 0.0033 0.0454 0.3657
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0054 0.0947 0.134
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0064 0.1167 1
Plasmodium vivax calcium-dependent protein kinase, putative 0.0032 0.0445 0.0404
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.0025 0.0272 0.11
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0064 0.1167 0.8763
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0064 0.1167 1
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0024 0.0243 0.1782
Trypanosoma brucei glucose transporter 1E 0.0033 0.0454 0.3657
Mycobacterium leprae Possible regulatory protein 0.0025 0.0272 0.1099
Mycobacterium leprae putative cytochrome p450 0.0064 0.1167 1
Leishmania major cytochrome p450-like protein 0.0064 0.1167 1
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.017 0.3622 0.5495
Echinococcus granulosus lysyl tRNA synthetase 0.0024 0.0243 0.0849
Giardia lamblia Prolyl-tRNA synthetase 0.0032 0.0429 1
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0037 0.055 0.4511
Plasmodium vivax hexose transporter 0.0105 0.2128 0.2094
Loa Loa (eye worm) hypothetical protein 0.0025 0.0272 0.0384
Plasmodium falciparum LCCL domain-containing protein 0.002 0.0153 0.0111
Echinococcus multilocularis lysyl tRNA synthetase 0.0024 0.0243 0.0849
Schistosoma mansoni lipoxygenase 0.0082 0.159 0.6556
Toxoplasma gondii cytochrome p450 superfamily protein 0.0064 0.1167 0.1727
Loa Loa (eye worm) sugar transporter 0.0015 0.0042 0.006
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0231 0.5006 0.7085
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0105 0.2128 0.8835
Loa Loa (eye worm) hypothetical protein 0.0015 0.0042 0.006
Brugia malayi PAS domain containing protein 0.0095 0.1896 0.264
Plasmodium vivax lysine--tRNA ligase, putative 0.0024 0.0243 0.0201
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0032 0.0445 0.0404
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0032 0.0444 0.0572
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0032 0.0429 0.1639
Brugia malayi follicle stimulating hormone receptor 0.0231 0.5006 0.7067
Loa Loa (eye worm) hypothetical protein 0.032 0.7066 1
Brugia malayi Cytochrome P450 family protein 0.0064 0.1167 0.1601
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0064 0.1167 0.8763
Echinococcus granulosus single minded 2 0.0071 0.1326 0.5438
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0024 0.0243 0.1562
Brugia malayi Cytochrome P450 family protein 0.0064 0.1167 0.1601
Trypanosoma cruzi hexose transporter 0.0033 0.0454 0.3657
Brugia malayi lysyl-tRNA synthetase 0.0024 0.0243 0.0285
Mycobacterium ulcerans putative regulatory protein 0.0071 0.1326 1
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0032 0.0444 0.0629
Leishmania major protein kinase, putative 0.0027 0.0318 0.2451
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0032 0.0445 0.0404
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0064 0.1167 1
Loa Loa (eye worm) hypothetical protein 0.0024 0.0243 0.0344
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0064 0.1167 1
Loa Loa (eye worm) major facilitator superfamily transporter 0.0015 0.0042 0.006
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0032 0.0445 0.0617
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0454 0.1973
Trypanosoma cruzi hexose transporter, putative 0.0033 0.0454 0.3657
Echinococcus multilocularis aryl hydrocarbon receptor 0.0025 0.0272 0.0972
Schistosoma mansoni protein kinase 0.0032 0.0444 0.1703
Trichomonas vaginalis adenylate cyclase, type VII, putative 0.0025 0.0272 0.11
Trypanosoma brucei glucose transporter, putative 0.0033 0.0454 0.3657
Schistosoma mansoni lipoxygenase 0.0117 0.2403 1
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0064 0.1167 1
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0064 0.1167 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0042 0.006
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0064 0.1167 0.8763
Leishmania major glucose transporter, lmgt3 0.0033 0.0454 0.3657
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0032 0.0444 0.0629
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0064 0.1167 0.8763
Schistosoma mansoni polycystin 1-related 0.002 0.0153 0.0468
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0064 0.1167 1
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0061 0.1115 0.4544
Plasmodium vivax proline--tRNA ligase, putative 0.0037 0.055 0.051
Loa Loa (eye worm) hypothetical protein 0.0015 0.0042 0.006
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0037 0.055 0.4511
Loa Loa (eye worm) hypothetical protein 0.0015 0.0042 0.006
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0024 0.0243 0.1782
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0064 0.1167 0.8763
Loa Loa (eye worm) plexin A 0.0025 0.0269 0.0381
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0064 0.1167 0.8763
Brugia malayi Cam kinase protein 1 0.0032 0.0444 0.0572
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0025 0.0272 1
Brugia malayi hypothetical protein 0.002 0.0153 0.0157
Entamoeba histolytica protein kinase, putative 0.0032 0.0444 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0042 0.006
Echinococcus multilocularis Polycystic kidney disease protein 0.002 0.0153 0.0468
Leishmania major lysyl-tRNA synthetase, putative 0.0024 0.0243 0.1782
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0058 0.1037 0.4213
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0032 0.0429 0.1855
Brugia malayi hypothetical protein 0.002 0.0153 0.0157
Schistosoma mansoni lysyl-tRNA synthetase 0.0024 0.0243 0.0849
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0064 0.1167 1
Giardia lamblia Lysyl-tRNA synthetase 0.0024 0.0243 0.5182
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0032 0.0429 0.0551
Trypanosoma brucei glucose transporter 2A 0.0033 0.0454 0.3657
Trypanosoma brucei glucose transporter, putative 0.0033 0.0454 0.3657
Schistosoma mansoni lysyl-tRNA synthetase 0.0024 0.0243 0.0849
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0454 0.1973
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0037 0.055 0.0779
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0025 0.0272 0.0384
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0064 0.1167 1
Echinococcus multilocularis transfer RNA-Lys 0.0071 0.1326 0.5438
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0105 0.2128 0.8835
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0032 0.0429 0.0551
Echinococcus granulosus cytochrome P450 2K1 0.0064 0.1167 0.4766
Loa Loa (eye worm) hypothetical protein 0.0015 0.0042 0.006
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.1115 0.4544
Brugia malayi Cytochrome P450 family protein 0.0064 0.1167 0.1601
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0025 0.0272 0.2039
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.1115 0.8355
Brugia malayi bHLH-PAS transcription factor 0.0071 0.1326 0.1827
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0032 0.0429 0.1639
Schistosoma mansoni protein kinase 0.0032 0.0444 0.1703
Brugia malayi Doublecortin family protein 0.002 0.0153 0.0157
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0025 0.0272 0.11
Toxoplasma gondii aldehyde dehydrogenase 0.0061 0.1115 0.1646
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0064 0.1167 0.8763
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0064 0.1167 0.8763
Schistosoma mansoni serine/threonine protein kinase 0.0032 0.0444 0.1703
Loa Loa (eye worm) hypothetical protein 0.0015 0.0042 0.006
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0058 0.1037 0.4213
Onchocerca volvulus 0.0021 0.0181 0.1081
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0058 0.1037 0.884
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0153 0.0468
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0024 0.0243 0.0961
Loa Loa (eye worm) hypothetical protein 0.0026 0.0293 0.0414
Plasmodium falciparum hexose transporter 0.0105 0.2128 0.2094
Schistosoma mansoni aryl hydrocarbon receptor 0.0095 0.1896 0.7855
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0064 0.1167 0.8763
Echinococcus granulosus Polycystic kidney disease protein 0.002 0.0153 0.0468
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0037 0.055 0.4511
Schistosoma mansoni single-minded 0.0095 0.1896 0.7855
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0058 0.1037 0.884
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.1115 0.8355
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0064 0.1167 1
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0024 0.0243 0.1562
Schistosoma mansoni glucose transport protein 0.0105 0.2128 0.8835
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.002 0.0161 0.1056
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0032 0.0444 0.1703
Trypanosoma brucei THT1 - hexose transporter, putative 0.0033 0.0454 0.3657
Trypanosoma brucei glucose transporter, putative 0.0033 0.0454 0.3657
Toxoplasma gondii protein kinase, putative 0.0298 0.6557 1
Echinococcus multilocularis General substrate transporter 0.0091 0.1787 0.739
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0064 0.1167 1
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0064 0.1167 0.8763
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0032 0.0444 0.1703
Plasmodium falciparum proline--tRNA ligase 0.0037 0.055 0.051
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0024 0.0243 0.0812
Loa Loa (eye worm) cytochrome P450 family protein 0.0064 0.1167 0.1652
Plasmodium falciparum calcium-dependent protein kinase 1 0.0032 0.0445 0.0404
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.002 0.0161 0.1056
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0153 0.0468
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0027 0.0318 0.2451
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0064 0.1167 1
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0153 0.0468
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0105 0.2128 0.8835
Trypanosoma cruzi hexose transporter, putative 0.0033 0.0454 0.3657
Brugia malayi hypothetical protein 0.032 0.7066 1
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0064 0.1167 1
Echinococcus granulosus General substrate transporter 0.0091 0.1787 0.739
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0025 0.0272 0.2039
Leishmania major glucose transporter, lmgt1 0.0033 0.0454 0.3657
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0032 0.0445 0.0617
Loa Loa (eye worm) hypothetical protein 0.0021 0.0181 0.0256
Loa Loa (eye worm) hypothetical protein 0.0032 0.0429 0.0607
Trypanosoma brucei cytochrome P450, putative 0.0064 0.1167 1
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0015 0.0042 0.5
Trypanosoma cruzi hexose transporter, putative 0.0033 0.0454 0.3657
Trichomonas vaginalis conserved hypothetical protein 0.0105 0.2128 1
Entamoeba histolytica protein kinase, putative 0.0032 0.0444 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0042 0.006
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0027 0.0318 0.2451
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0058 0.1037 0.7747
Leishmania major glucose transporter/membrane transporter D2, putative 0.0033 0.0454 0.3657
Loa Loa (eye worm) hypothetical protein 0.0015 0.0042 0.006
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0032 0.0429 0.9253
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0058 0.1037 0.7747
Trichomonas vaginalis glucose transporter, putative 0.0033 0.0454 0.1973
Trypanosoma brucei glucose transporter, putative 0.0033 0.0454 0.3657
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0105 0.2128 0.8835
Plasmodium falciparum calcium-dependent protein kinase 2 0.0032 0.0445 0.0404
Brugia malayi Cytochrome P450 family protein 0.0197 0.4237 0.5973
Trypanosoma cruzi hexose transporter, putative 0.0018 0.0113 0.0624
Plasmodium falciparum protein kinase 7 0.0298 0.6557 0.6542
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0064 0.1167 1
Schistosoma mansoni hypothetical protein 0.0105 0.2128 0.8835
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0064 0.1167 0.8763
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0032 0.0429 0.2664
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0021 0.0176 0.0641
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0037 0.055 0.4511
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0061 0.1115 0.4544
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0032 0.0445 0.0404
Echinococcus granulosus Aryl hydrocarbon receptor nuclear 0.0025 0.0272 0.0972
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0454 0.1973
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0032 0.0445 0.0617
Schistosoma mansoni cytochrome P450 0.0064 0.1167 0.4766
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0032 0.0444 0.1703
Plasmodium vivax multidomain scavenger receptor, putative 0.002 0.0153 0.0111
Plasmodium falciparum calcium-dependent protein kinase 3 0.0032 0.0445 0.0404
Brugia malayi cytochrome P450 0.0064 0.1167 0.1601
Echinococcus granulosus RUN 0.002 0.0153 0.0468
Schistosoma mansoni hypothetical protein 0.0064 0.1167 0.4766
Echinococcus multilocularis Aryl hydrocarbon receptor nuclear 0.0025 0.0272 0.0972
Plasmodium falciparum calcium-dependent protein kinase 5 0.0032 0.0445 0.0404
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0032 0.0429 0.1639
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0058 0.1037 0.4213
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0064 0.1167 1
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0064 0.1167 1
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0064 0.1167 1
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0153 0.0468
Loa Loa (eye worm) hypothetical protein 0.0032 0.0429 0.0607
Schistosoma mansoni rab6-interacting 0.002 0.0153 0.0468
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0064 0.1167 0.8763
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0064 0.1167 1
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0064 0.1167 1
Echinococcus granulosus calcium dependent protein kinase 0.003 0.0398 0.1508
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0064 0.1167 0.8763
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0105 0.2128 0.8835
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0037 0.055 0.4511
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0027 0.0318 0.2451
Brugia malayi Sugar transporter family protein 0.0105 0.2128 0.2969
Loa Loa (eye worm) hypothetical protein 0.002 0.0153 0.0216
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0064 0.1167 1
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0032 0.0444 0.1703
Schistosoma mansoni protein kinase 0.0032 0.0444 0.1703
Loa Loa (eye worm) cytochrome P450 family protein 0.0064 0.1167 0.1652
Trypanosoma brucei glucose transporter, putative 0.0033 0.0454 0.3657
Loa Loa (eye worm) hypothetical protein 0.002 0.0153 0.0216
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0025 0.0272 0.11
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0454 0.1973
Loa Loa (eye worm) hypoxia-induced factor 1 0.0295 0.6495 0.9193
Onchocerca volvulus 0.0025 0.0272 0.1787
Loa Loa (eye worm) major facilitator superfamily transporter 0.0015 0.0042 0.006
Trypanosoma brucei glucose transporter, putative 0.0033 0.0454 0.3657
Trypanosoma brucei glucose transporter, putative 0.0033 0.0454 0.3657
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0032 0.0429 0.1639
Echinococcus multilocularis plexin a4 0.0025 0.0269 0.096
Leishmania major protein kinase, putative 0.0027 0.0318 0.2451
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0272 0.11
Loa Loa (eye worm) hypothetical protein 0.0032 0.0444 0.0629
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0117 0.2403 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0042 0.006
Echinococcus multilocularis RUN 0.002 0.0153 0.0468
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0064 0.1167 0.8763
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0064 0.1167 1
Echinococcus multilocularis 0.0064 0.1167 0.4766
Echinococcus granulosus plexin a4 0.0025 0.0269 0.096
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0454 0.1973
Loa Loa (eye worm) hypothetical protein 0.0015 0.0042 0.006
Loa Loa (eye worm) hypothetical protein 0.0015 0.0042 0.006
Leishmania major cytochrome p450-like protein 0.0064 0.1167 1
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0032 0.0444 0.1703
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0064 0.1167 0.8763
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0105 0.2128 0.8835
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0032 0.0444 0.1703
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0105 0.2128 0.8835
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0027 0.0318 0.2451
Trichomonas vaginalis CAMK family protein kinase 0.0032 0.0444 0.1927
Plasmodium vivax CDK-related protein kinase 6, putative 0.0448 1 1
Schistosoma mansoni hypothetical protein 0.002 0.0153 0.0468
Echinococcus granulosus aryl hydrocarbon receptor 0.0025 0.0272 0.0972
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.017 0.3622 0.3595
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0272 0.11
Trypanosoma cruzi cytochrome P450, putative 0.0064 0.1167 1
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0058 0.1037 0.1416
Trichomonas vaginalis adenylate cyclase, putative 0.0025 0.0272 0.11
Plasmodium falciparum lysine--tRNA ligase 0.0024 0.0243 0.0201
Schistosoma mansoni plexin 0.0021 0.0181 0.0588
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0032 0.0444 0.1703
Brugia malayi plexin A 0.0025 0.0269 0.0323
Loa Loa (eye worm) cytochrome P450 family protein 0.0197 0.4237 0.5997

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 210 nM Inhibition of human c-MET ChEMBL. 21641696

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.