Detailed information for compound 1045024

Basic information

Technical information
  • TDR Targets ID: 1045024
  • Name: 3-(3-hydroxy-2-methylpropyl)-5-(4-methylsulfo nylphenoxy)-N-(1,3-thiazol-2-yl)benzamide
  • MW: 446.54 | Formula: C21H22N2O5S2
  • H donors: 2 H acceptors: 5 LogP: 3.26 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: OCC(Cc1cc(Oc2ccc(cc2)S(=O)(=O)C)cc(c1)C(=O)Nc1nccs1)C
  • InChi: 1S/C21H22N2O5S2/c1-14(13-24)9-15-10-16(20(25)23-21-22-7-8-29-21)12-18(11-15)28-17-3-5-19(6-4-17)30(2,26)27/h3-8,10-12,14,24H,9,13H2,1-2H3,(H,22,23,25)
  • InChiKey: DHUKEKJJKQRFSO-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3-(3-hydroxy-2-methyl-propyl)-5-(4-methylsulfonylphenoxy)-N-thiazol-2-yl-benzamide
  • 3-(3-hydroxy-2-methylpropyl)-5-(4-methylsulfonylphenoxy)-N-(2-thiazolyl)benzamide
  • 3-(3-hydroxy-2-methyl-propyl)-5-(4-mesylphenoxy)-N-thiazol-2-yl-benzamide
  • 3-(3-hydroxy-2-methyl-propyl)-5-(4-methylsulfonylphenoxy)-N-(1,3-thiazol-2-yl)benzamide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens glucokinase (hexokinase 4) Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Leishmania major hexokinase, putative Get druggable targets OG5_126743 All targets in OG5_126743
Trypanosoma brucei hexokinase Get druggable targets OG5_126743 All targets in OG5_126743
Trypanosoma congolense hexokinase Get druggable targets OG5_126743 All targets in OG5_126743
Trypanosoma cruzi hexokinase, putative Get druggable targets OG5_126743 All targets in OG5_126743
Plasmodium yoelii hexokinase Get druggable targets OG5_126743 All targets in OG5_126743
Trypanosoma brucei gambiense hexokinase, putative Get druggable targets OG5_126743 All targets in OG5_126743
Echinococcus granulosus hexokinase Get druggable targets OG5_126743 All targets in OG5_126743
Echinococcus granulosus hexokinase type 2 Get druggable targets OG5_126743 All targets in OG5_126743
Candida albicans one of four closely related hexokinase-like genes similar to P.angusta GLK1 and to S. cerevisiae Glucokinase GLK1 (YCL040W) Get druggable targets OG5_126743 All targets in OG5_126743
Echinococcus multilocularis hexokinase Get druggable targets OG5_126743 All targets in OG5_126743
Treponema pallidum hexokinase (hxk) Get druggable targets OG5_126743 All targets in OG5_126743
Schistosoma japonicum ko:K00844 hexokinase [EC2.7.1.1], putative Get druggable targets OG5_126743 All targets in OG5_126743
Plasmodium vivax hexokinase, putative Get druggable targets OG5_126743 All targets in OG5_126743
Echinococcus multilocularis hexokinase Get druggable targets OG5_126743 All targets in OG5_126743
Trypanosoma brucei gambiense hexokinase, putative Get druggable targets OG5_126743 All targets in OG5_126743
Candida albicans one of four closely related hexokinase-like genes similar to P.angusta GLK1 and to S. cerevisiae Glucokinase GLK1 (YCL040W) Get druggable targets OG5_126743 All targets in OG5_126743
Leishmania mexicana hexokinase, putative Get druggable targets OG5_126743 All targets in OG5_126743
Leishmania braziliensis hexokinase, putative Get druggable targets OG5_126743 All targets in OG5_126743
Echinococcus granulosus hexokinase Get druggable targets OG5_126743 All targets in OG5_126743
Plasmodium falciparum hexokinase Get druggable targets OG5_126743 All targets in OG5_126743
Candida albicans one of four closely related hexokinase-like genes similar to P.angusta GLK1 and to S. cerevisiae Glucokinase GLK1 (YCL040W) Get druggable targets OG5_126743 All targets in OG5_126743
Onchocerca volvulus Get druggable targets OG5_126743 All targets in OG5_126743
Onchocerca volvulus Get druggable targets OG5_126743 All targets in OG5_126743
Onchocerca volvulus Get druggable targets OG5_126743 All targets in OG5_126743
Leishmania infantum hexokinase, putative Get druggable targets OG5_126743 All targets in OG5_126743
Echinococcus multilocularis hexokinase type 2 Get druggable targets OG5_126743 All targets in OG5_126743
Leishmania major hexokinase, putative Get druggable targets OG5_126743 All targets in OG5_126743
Babesia bovis hexokinase Get druggable targets OG5_126743 All targets in OG5_126743
Leishmania mexicana hexokinase, putative Get druggable targets OG5_126743 All targets in OG5_126743
Theileria parva hexokinase, putative Get druggable targets OG5_126743 All targets in OG5_126743
Loa Loa (eye worm) hexokinase type II Get druggable targets OG5_126743 All targets in OG5_126743
Candida albicans one of four closely related hexokinase-like genes similar to P.angusta GLK1 and to S. cerevisiae Glucokinase GLK1 (YCL040W) Get druggable targets OG5_126743 All targets in OG5_126743
Trypanosoma brucei hexokinase Get druggable targets OG5_126743 All targets in OG5_126743
Candida albicans one of four closely related hexokinase-like genes similar to P.angusta GLK1 and to S. cerevisiae Glucokinase GLK1 (YCL040W) Get druggable targets OG5_126743 All targets in OG5_126743
Entamoeba histolytica hexokinase 2 Get druggable targets OG5_126743 All targets in OG5_126743
Candida albicans similar to D.occidentalis hexokinase HXK which is able to phosphorylate glucose and fructose Get druggable targets OG5_126743 All targets in OG5_126743
Brugia malayi hexokinase Get druggable targets OG5_126743 All targets in OG5_126743
Schistosoma mansoni hexokinase Get druggable targets OG5_126743 All targets in OG5_126743
Toxoplasma gondii hexokinase Get druggable targets OG5_126743 All targets in OG5_126743
Echinococcus granulosus hexokinase Get druggable targets OG5_126743 All targets in OG5_126743
Candida albicans one of four closely related hexokinase-like genes similar to P.angusta GLK1 and to S. cerevisiae GLK1 (YCL040W) Get druggable targets OG5_126743 All targets in OG5_126743
Neospora caninum cDNA FLJ57348, highly similar to Homo sapiens hexokinase domain containing 1 (HKDC1), mRNA, related Get druggable targets OG5_126743 All targets in OG5_126743
Candida albicans similar to D.occidentalis hexokinase HXK which is able to phosphorylate glucose and fructose Get druggable targets OG5_126743 All targets in OG5_126743
Leishmania infantum hexokinase, putative Get druggable targets OG5_126743 All targets in OG5_126743
Plasmodium berghei hexokinase, putative Get druggable targets OG5_126743 All targets in OG5_126743
Loa Loa (eye worm) hexokinase Get druggable targets OG5_126743 All targets in OG5_126743
Entamoeba histolytica hexokinase 1 Get druggable targets OG5_126743 All targets in OG5_126743
Loa Loa (eye worm) hexokinase Get druggable targets OG5_126743 All targets in OG5_126743
Theileria parva hexokinase, putative Get druggable targets OG5_126743 All targets in OG5_126743
Leishmania donovani hexokinase, putative Get druggable targets OG5_126743 All targets in OG5_126743
Plasmodium knowlesi hexokinase, putative Get druggable targets OG5_126743 All targets in OG5_126743
Candida albicans one of four closely related hexokinase-like genes similar to P.angusta GLK1 and to S. cerevisiae Glucokinase GLK1 (YCL040W) Get druggable targets OG5_126743 All targets in OG5_126743
Cryptosporidium hominis hexokinase i Get druggable targets OG5_126743 All targets in OG5_126743
Cryptosporidium parvum hexokinase Get druggable targets OG5_126743 All targets in OG5_126743
Trypanosoma cruzi hexokinase, putative Get druggable targets OG5_126743 All targets in OG5_126743
Trypanosoma brucei hexokinase, putative Get druggable targets OG5_126743 All targets in OG5_126743
Brugia malayi Hexokinase family protein Get druggable targets OG5_126743 All targets in OG5_126743
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126743 All targets in OG5_126743
Echinococcus multilocularis hexokinase Get druggable targets OG5_126743 All targets in OG5_126743
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi Hexokinase family protein glucokinase (hexokinase 4) 465 aa 470 aa 30.0 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0043 0.0146 0.0146
Loa Loa (eye worm) NEK/NEK6 protein kinase 0.022 0.2789 0.2789
Echinococcus multilocularis cyclin y 0.004 0.0096 0.0096
Trichomonas vaginalis CMGC family protein kinase 0.01 0.0991 0.1615
Trichomonas vaginalis cyclins, putative 0.0237 0.3036 0.4947
Echinococcus multilocularis cyclins 0.0144 0.1649 0.1649
Brugia malayi SH2 domain containing protein 0.0037 0.0056 0.0056
Brugia malayi tRNA modification GTPase TrmE family protein 0.0037 0.0056 0.0056
Schistosoma mansoni protein kinase 0.0202 0.2523 0.2523
Loa Loa (eye worm) hexokinase 0.0096 0.094 0.094
Trypanosoma cruzi mitotic cyclin, putative 0.004 0.0096 0.0206
Echinococcus multilocularis serine:threonine protein kinase PAK 4 0.0181 0.2204 0.2204
Echinococcus granulosus SH2 motif 0.0037 0.0056 0.0056
Echinococcus multilocularis cyclin G2 0.004 0.0096 0.0096
Plasmodium falciparum hexokinase 0.0096 0.094 0.5635
Plasmodium falciparum cyclin dependent kinase binding protein, putative 0.004 0.0096 0.0434
Loa Loa (eye worm) hypothetical protein 0.0037 0.0056 0.0056
Schistosoma mansoni nck2/grb4 0.0051 0.0264 0.0264
Echinococcus multilocularis serine threonine protein kinase 0.0116 0.123 0.123
Giardia lamblia Hypothetical protein 0.004 0.0096 0.0115
Loa Loa (eye worm) STE/STE20/YSK protein kinase 0.0116 0.123 0.123
Echinococcus multilocularis neuroglian 0.0049 0.0229 0.0229
Schistosoma mansoni protein tyrosine phosphatase n11 (shp2) 0.0037 0.0056 0.0056
Entamoeba histolytica serine/threonine- protein kinase 6, putative 0.0126 0.1386 0.4566
Echinococcus multilocularis cyclins 0.0144 0.1649 0.1649
Echinococcus multilocularis hexokinase type 2 0.0096 0.094 0.094
Entamoeba histolytica protein kinase, putative 0.0126 0.1386 0.4566
Echinococcus granulosus Cyclin L1 0.004 0.0096 0.0096
Giardia lamblia Cyclin A 0.0144 0.1649 0.2658
Trypanosoma cruzi cyclin, putative 0.0237 0.3036 0.8774
Trichomonas vaginalis cyclins, putative 0.0132 0.1482 0.2415
Echinococcus multilocularis tyrosine protein kinase Srms 0.0064 0.0465 0.0465
Echinococcus multilocularis serine:threonine protein kinase TAO1 0.0202 0.2522 0.2522
Loa Loa (eye worm) hypothetical protein 0.0037 0.0056 0.0056
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0108 0.1122 0.1122
Echinococcus granulosus hexokinase 0.0096 0.094 0.094
Loa Loa (eye worm) STE/STE20/PAKB protein kinase 0.0196 0.2436 0.2436
Echinococcus granulosus fibroblast growth factor receptor 4 0.0126 0.1383 0.1383
Brugia malayi SRC-1 0.0078 0.0673 0.0673
Loa Loa (eye worm) hexokinase 0.0096 0.094 0.094
Echinococcus multilocularis 0.0037 0.0056 0.0056
Trichomonas vaginalis cyclin B, putative 0.0237 0.3036 0.4947
Loa Loa (eye worm) TK/FAK protein kinase 0.0282 0.3707 0.3707
Brugia malayi SH2 domain containing protein 0.0037 0.0056 0.0056
Brugia malayi Cyclin, N-terminal domain containing protein 0.0237 0.3036 0.3036
Schistosoma mansoni tyrosine kinase 0.0461 0.6384 0.6384
Echinococcus multilocularis cyclin dependent kinase 5 activator 1 0.0255 0.3316 0.3316
Echinococcus granulosus hexokinase 0.0096 0.094 0.094
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0078 0.0673 0.0673
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0246 0.3175 0.3175
Loa Loa (eye worm) hypothetical protein 0.0037 0.0056 0.0056
Loa Loa (eye worm) hypothetical protein 0.0082 0.0727 0.0727
Echinococcus multilocularis tyrosine protein kinase shark 0.0488 0.6788 0.6788
Trichomonas vaginalis CMGC family protein kinase 0.01 0.0991 0.1615
Schistosoma mansoni serine/threonine protein kinase 0.0054 0.0313 0.0313
Giardia lamblia Kinase, AGC PKA 0.0054 0.0313 0.0471
Echinococcus granulosus mitogen activated protein kinase 3 0.0065 0.0472 0.0472
Entamoeba histolytica cyclin family protein 0.0144 0.1649 0.5433
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0078 0.0673 0.0673
Schistosoma mansoni tyrosine kinase 0.0064 0.0465 0.0465
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.004 0.0096 0.0434
Loa Loa (eye worm) CAMK/CAMKL/NIM1 protein kinase 0.0096 0.0941 0.0941
Loa Loa (eye worm) hypothetical protein 0.0054 0.0313 0.0313
Trichomonas vaginalis cyclin D, putative 0.0144 0.1649 0.2688
Trypanosoma brucei mitogen-activated protein kinase 3, putative 0.0265 0.3456 1
Trichomonas vaginalis cyclin B, putative 0.0144 0.1649 0.2688
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0265 0.3456 1
Plasmodium vivax glycogen synthase kinase 3, putative 0.0062 0.0428 0.2964
Echinococcus multilocularis roundabout 2 0.0052 0.0286 0.0286
Echinococcus granulosus cyclins 0.0144 0.1649 0.1649
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.0043 0.0146 0.0146
Giardia lamblia Hypothetical protein 0.004 0.0096 0.0115
Brugia malayi Protein kinase domain containing protein 0.017 0.2041 0.2041
Schistosoma mansoni tyrosine kinase 0.0488 0.6788 0.6788
Leishmania major protein kinase A catalytic subunit 0.0054 0.0313 0.0646
Schistosoma mansoni shc transforming protein 0.0037 0.0056 0.0056
Brugia malayi Sex muscle abnormal protein 5 0.0051 0.0264 0.0264
Echinococcus multilocularis tensin 0.0037 0.0056 0.0056
Schistosoma mansoni signal transduction protein lnk-related 0.0037 0.0056 0.0056
Brugia malayi Cyclin, N-terminal domain containing protein 0.004 0.0096 0.0096
Echinococcus granulosus phosphatidylinositol 3 kinase regulatory subunit 0.0037 0.0056 0.0056
Toxoplasma gondii protein kinase, cAMP-dependent, catalytic chain 0.0054 0.0313 0.1682
Onchocerca volvulus 0.006 0.0406 0.0537
Brugia malayi cAMP-dependent protein kinase catalytic subunit, putative 0.0054 0.0313 0.0313
Trichomonas vaginalis cyclin A, putative 0.004 0.0096 0.0156
Loa Loa (eye worm) TK/FER protein kinase 0.0064 0.0465 0.0465
Brugia malayi Cyclin, N-terminal domain containing protein 0.0237 0.3036 0.3036
Echinococcus granulosus macrophage colony stimulating factor 1 receptor 0.0579 0.8135 0.8135
Loa Loa (eye worm) hypothetical protein 0.0106 0.1089 0.1089
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0078 0.0673 0.0673
Brugia malayi Variant SH3 domain containing protein 0.0043 0.0146 0.0146
Loa Loa (eye worm) TK/FER protein kinase 0.0064 0.0465 0.0465
Entamoeba histolytica protein kinase, putative 0.0116 0.123 0.4052
Schistosoma mansoni serine/threonine protein kinase 0.0065 0.0472 0.0472
Echinococcus multilocularis suppressor of cytokine signaling 7 0.0037 0.0056 0.0056
Plasmodium vivax hypothetical protein, conserved 0.004 0.0096 0.0518
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 1 0.0054 0.0313 0.0838
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0064 0.0465 0.1533
Trypanosoma brucei hexokinase, putative 0.0096 0.094 0.2514
Loa Loa (eye worm) RhoGAP domain-containing protein 0.0043 0.0146 0.0146
Loa Loa (eye worm) cytokine inducible SH2-containing protein 5 0.0037 0.0056 0.0056
Entamoeba histolytica protein kinase domain containing protein 0.0042 0.0129 0.0425
Schistosoma mansoni tyrosine kinase 0.0078 0.0673 0.0673
Schistosoma mansoni serine/threonine protein kinase 0.008 0.0696 0.0696
Trichomonas vaginalis CMGC family protein kinase 0.0062 0.0428 0.0698
Schistosoma mansoni cyclin B3 0.0255 0.3306 0.3306
Brugia malayi Protein kinase domain containing protein 0.0202 0.2523 0.2523
Echinococcus multilocularis cyclin dependent kinase 5 0.01 0.0991 0.0991
Echinococcus granulosus insulin receptor 0.0461 0.6384 0.6384
Schistosoma mansoni serine/threonine protein kinase 0.004 0.0109 0.0109
Loa Loa (eye worm) hypothetical protein 0.0043 0.0141 0.0141
Loa Loa (eye worm) hypothetical protein 0.0143 0.1632 0.1632
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0461 0.6384 0.6384
Loa Loa (eye worm) hypothetical protein 0.0066 0.0484 0.0484
Echinococcus multilocularis mitogen activated protein kinase 11 0.0265 0.3456 0.3456
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 2 0.0054 0.0313 0.0838
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0078 0.0673 0.0673
Brugia malayi hexokinase 0.0096 0.094 0.094
Trichomonas vaginalis cyclins, putative 0.0237 0.3036 0.4947
Echinococcus granulosus mitogen activated protein kinase 14 0.0265 0.3456 0.3456
Brugia malayi hypothetical protein 0.0202 0.2522 0.2522
Loa Loa (eye worm) hypothetical protein 0.0093 0.0892 0.0892
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0078 0.0673 0.0673
Brugia malayi Protein kinase domain containing protein 0.0064 0.0465 0.0465
Loa Loa (eye worm) hypothetical protein 0.0037 0.0056 0.0056
Schistosoma mansoni protein kinase 0.0042 0.0129 0.0129
Echinococcus multilocularis cdk5 and abl1 enzyme substrate 1 0.004 0.0096 0.0096
Echinococcus granulosus G1:S specific cyclin D1 0.004 0.0096 0.0096
Trichomonas vaginalis CMGC family protein kinase 0.0445 0.6136 1
Loa Loa (eye worm) TK/FER protein kinase 0.0064 0.0465 0.0465
Schistosoma mansoni tensin 0.0037 0.0056 0.0056
Loa Loa (eye worm) AGC/PKC/ALPHA protein kinase 0.0055 0.0326 0.0326
Schistosoma mansoni g1/s-specific cyclin C 0.004 0.0096 0.0096
Onchocerca volvulus 0.0064 0.0465 0.0628
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0043 0.0141 0.0141
Echinococcus granulosus epidermal growth factor receptor 0.0497 0.6917 0.6917
Echinococcus granulosus epidermal growth factor receptor 0.0704 1 1
Echinococcus granulosus Pyruvate dehydrogenase lipoamide kinase 0.0119 0.1277 0.1277
Echinococcus granulosus protein kinase shaggy 0.0062 0.0428 0.0428
Schistosoma mansoni serine/threonine protein kinase 0.0057 0.0355 0.0355
Trichomonas vaginalis cyclin B3, putative 0.004 0.0096 0.0156
Loa Loa (eye worm) CAMK/CAMKL/CHK1 protein kinase 0.0181 0.2205 0.2205
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0064 0.0465 0.0465
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0062 0.0428 0.0428
Trichomonas vaginalis cyclins, putative 0.0237 0.3036 0.4947
Brugia malayi serine/threonine-protein kinase 6 0.0126 0.1386 0.1386
Echinococcus granulosus protein kinase C gamma type 0.0074 0.0606 0.0606
Echinococcus multilocularis cyclins 0.0144 0.1649 0.1649
Echinococcus granulosus serine:threonine protein kinase 12 B 0.0126 0.1386 0.1386
Trichomonas vaginalis AGC family protein kinase 0.0056 0.0336 0.0547
Brugia malayi Protein kinase domain containing protein 0.0086 0.0787 0.0787
Leishmania major protein kinase, putative 0.0042 0.0129 0.01
Schistosoma mansoni pyruvate dehydrogenase 0.0119 0.1277 0.1277
Trichomonas vaginalis cyclin B3, putative 0.0144 0.1649 0.2688
Schistosoma mansoni atypical protein kinase C 0.0039 0.009 0.009
Echinococcus granulosus tyrosine protein kinase Src42A 0.0037 0.0056 0.0056
Trichomonas vaginalis cyclins, putative 0.004 0.0096 0.0156
Echinococcus multilocularis suppressor of cytokine signaling 6 0.0037 0.0056 0.0056
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0096 0.0156
Brugia malayi Hexokinase family protein 0.006 0.0406 0.0406
Schistosoma mansoni Neurotrimin precursor (hNT) 0.0043 0.0141 0.0141
Loa Loa (eye worm) TK/FER protein kinase 0.0064 0.0465 0.0465
Toxoplasma gondii hypothetical protein 0.0104 0.1059 0.7469
Trichomonas vaginalis CMGC family protein kinase 0.0445 0.6136 1
Echinococcus multilocularis Immunoglobulin 0.0043 0.0141 0.0141
Brugia malayi Tensin 0.0037 0.0056 0.0056
Echinococcus multilocularis SH2 motif 0.0037 0.0056 0.0056
Echinococcus multilocularis SHC transforming protein 3 0.0037 0.0056 0.0056
Echinococcus multilocularis tyrosine protein kinase ABL1 0.027 0.3536 0.3536
Schistosoma mansoni tyrosine kinase 0.0078 0.0673 0.0673
Entamoeba histolytica cyclin family protein 0.0144 0.1649 0.5433
Echinococcus multilocularis G1:S specific cyclin D1 0.004 0.0096 0.0096
Onchocerca volvulus Cyclin L homolog 0.004 0.0096 0.0061
Loa Loa (eye worm) AGC/PKA protein kinase 0.0054 0.0313 0.0313
Schistosoma mansoni serine/threonine protein kinase 0.0054 0.0313 0.0313
Loa Loa (eye worm) TK protein kinase 0.0064 0.0465 0.0465
Echinococcus granulosus G2:mitotic specific cyclin B3 0.0255 0.3306 0.3306
Loa Loa (eye worm) hypothetical protein 0.0039 0.0086 0.0086
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0461 0.6384 0.6384
Onchocerca volvulus Protein CNPPD1 homolog 0.004 0.0096 0.0061
Echinococcus multilocularis cyclin dependent kinase 1 0.01 0.0991 0.0991
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.01 0.0991 0.2664
Plasmodium vivax cAMP-dependent protein kinase catalytic subunit, putative 0.0054 0.0313 0.2113
Echinococcus multilocularis phosphatidylinositol 3 kinase regulatory subunit 0.0037 0.0056 0.0056
Schistosoma mansoni tyrosine kinase 0.0126 0.1383 0.1383
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0054 0.0313 0.0313
Brugia malayi Variant SH3 domain containing protein 0.0051 0.0264 0.0264
Brugia malayi hypothetical protein 0.004 0.0096 0.0096
Onchocerca volvulus 0.0474 0.657 1
Schistosoma mansoni cyclin d 0.004 0.0096 0.0096
Schistosoma mansoni tensin 0.0037 0.0056 0.0056
Echinococcus granulosus SH2 domain containing protein 7 0.0037 0.0056 0.0056
Loa Loa (eye worm) hypothetical protein 0.0082 0.0727 0.0727
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0078 0.0673 0.0673
Leishmania major hexokinase, putative 0.0096 0.094 0.2514
Plasmodium vivax protein kinase Crk2 0.01 0.0991 0.7097
Trichomonas vaginalis AGC family protein kinase 0.0041 0.0117 0.0191
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0037 0.0056 0.0056
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0048 0.0224 0.0993
Schistosoma mansoni tyrosine kinase 0.0233 0.2986 0.2986
Brugia malayi serine/threonine-protein kinase PAK 7 0.0196 0.2436 0.2436
Echinococcus multilocularis protein tyrosine kinase 0.0279 0.3662 0.3662
Entamoeba histolytica serine/threonine protein kinase, putative 0.0108 0.1122 0.3695
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0054 0.0305 0.0305
Brugia malayi Protein kinase domain containing protein 0.0474 0.657 0.657
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.0062 0.0428 0.1176
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0037 0.0056 0.0089
Schistosoma mansoni hypothetical protein 0.0037 0.0056 0.0056
Giardia lamblia Kinase, CMGC CDK 0.01 0.0991 0.1581
Trichomonas vaginalis AGC family protein kinase 0.0056 0.0336 0.0547
Echinococcus granulosus serine/threonine protein kinase 0.0037 0.0056 0.0056
Onchocerca volvulus Tyrosine kinase homolog 0.0206 0.2572 0.3863
Schistosoma mansoni tyrosine kinase 0.0469 0.6508 0.6508
Entamoeba histolytica protein kinase domain containing protein 0.0126 0.1386 0.4566
Loa Loa (eye worm) hypothetical protein 0.0119 0.1277 0.1277
Echinococcus multilocularis c src tyrosine kinase 0.0078 0.0673 0.0673
Loa Loa (eye worm) IKK protein kinase 0.0474 0.657 0.657
Trichomonas vaginalis STE family protein kinase 0.0116 0.123 0.2005
Brugia malayi Protein kinase domain containing protein 0.0064 0.0465 0.0465
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0054 0.0313 0.0313
Entamoeba histolytica hexokinase 2 0.0096 0.094 0.3097
Schistosoma mansoni hypothetical protein 0.004 0.0096 0.0096
Loa Loa (eye worm) TK/FER protein kinase 0.0064 0.0465 0.0465
Echinococcus granulosus cyclin y 0.004 0.0096 0.0096
Echinococcus granulosus cyclins 0.004 0.0096 0.0096
Echinococcus granulosus calcium:calmodulin dependent protein kinase 0.0035 0.0025 0.0025
Loa Loa (eye worm) hypothetical protein 0.0037 0.0056 0.0056
Echinococcus granulosus tyrosine protein kinase ABL1 0.027 0.3536 0.3536
Echinococcus granulosus tyrosine protein kinase Fyn 0.0078 0.0673 0.0673
Giardia lamblia Cyclin B-like protein 0.004 0.0096 0.0115
Loa Loa (eye worm) TK/EGFR protein kinase 0.0704 1 1
Loa Loa (eye worm) cyclin domain-containing protein 0.004 0.0096 0.0096
Loa Loa (eye worm) cyclin domain-containing protein 0.0255 0.3306 0.3306
Onchocerca volvulus 0.0064 0.0465 0.0628
Trichomonas vaginalis AGC family protein kinase 0.0056 0.0336 0.0547
Trypanosoma brucei cdc2-related kinase 1 0.01 0.0991 0.2664
Brugia malayi serine/threonine-protein kinase plk-2 0.0108 0.1122 0.1122
Loa Loa (eye worm) TK/ALK protein kinase 0.0262 0.3417 0.3417
Trichomonas vaginalis CMGC family protein kinase 0.0065 0.0472 0.0769
Trypanosoma brucei protein kinase, putative 0.0042 0.0129 0.01
Echinococcus granulosus SHC transforming protein 3 0.0037 0.0056 0.0056
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0042 0.0129 0.0304
Brugia malayi p70 ribosomal S6 kinase beta 0.0054 0.0305 0.0305
Echinococcus granulosus tensin C1 domain containing phosphatase 0.0037 0.0056 0.0056
Loa Loa (eye worm) hypothetical protein 0.004 0.0096 0.0096
Schistosoma mansoni tyrosine kinase 0.0078 0.0673 0.0673
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0065 0.0472 0.2914
Echinococcus multilocularis oligomeric golgi complex subunit 3 0.004 0.0096 0.0096
Schistosoma mansoni serine/threonine protein kinase 0.0445 0.6136 0.6136
Echinococcus granulosus tyrosine protein kinase Srms 0.0064 0.0465 0.0465
Trypanosoma cruzi hexokinase, putative 0.0096 0.094 0.2668
Schistosoma mansoni tyrosine kinase 0.0279 0.3662 0.3662
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0046 0.0197 0.0197
Echinococcus multilocularis cyclin k 0.004 0.0096 0.0096
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.0119 0.1277 0.1277
Trichomonas vaginalis AGC family protein kinase 0.0056 0.0336 0.0547
Entamoeba histolytica PH domain containing protein kinase, putative 0.0056 0.0343 0.113
Brugia malayi map kinase activated protein kinase protein 2 0.0194 0.2394 0.2394
Trichomonas vaginalis cyclin A, putative 0.0237 0.3036 0.4947
Loa Loa (eye worm) hypothetical protein 0.0037 0.0056 0.0056
Loa Loa (eye worm) STE/STE20/TAO protein kinase 0.0202 0.2522 0.2522
Loa Loa (eye worm) hypothetical protein 0.0237 0.3036 0.3036
Brugia malayi Protein kinase domain containing protein 0.01 0.0991 0.0991
Trypanosoma brucei cdc2-related kinase 3 0.01 0.0991 0.2664
Giardia lamblia Kinase, CMGC MAPK 0.0065 0.0472 0.0731
Echinococcus multilocularis RNA directed DNA polymerase 0.0039 0.0093 0.0093
Entamoeba histolytica PH domain containing protein kinase, putative 0.0037 0.0056 0.0183
Echinococcus granulosus tyrosine protein kinase Fyn 0.0078 0.0673 0.0673
Schistosoma mansoni proteasome subunit alpha 1 (T01 family) 0.004 0.0096 0.0096
Loa Loa (eye worm) hypothetical protein 0.0085 0.0777 0.0777
Echinococcus granulosus N chimaerin 0.0043 0.0146 0.0146
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0065 0.0472 0.0472
Schistosoma mansoni serine/threonine protein kinase 0.0033 0.0005 0.0005
Echinococcus granulosus cyclin dependent kinase 9 0.0067 0.0505 0.0505
Trypanosoma brucei developmentally regulated phosphoprotein 0.0119 0.1277 0.3517
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0054 0.0313 0.0313
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.0054 0.0313 0.0838
Entamoeba histolytica protein kinase 2, putative 0.0035 0.0025 0.0082
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.01 0.0991 0.0991
Plasmodium vivax serine/threonine protein kinase 6, putative 0.0126 0.1386 1
Echinococcus multilocularis N chimaerin 0.0043 0.0146 0.0146
Trypanosoma brucei protein kinase A catalytic subunit, putative 0.0054 0.0313 0.0646
Schistosoma mansoni cyclin k 0.004 0.0096 0.0096
Echinococcus granulosus growth factor receptor bound protein 2 0.0051 0.0264 0.0264
Brugia malayi Variant SH3 domain containing protein 0.0051 0.0264 0.0264
Schistosoma mansoni suppressor of cytokine signaling 0.0037 0.0056 0.0056
Schistosoma mansoni tyrosine kinase 0.0037 0.006 0.006
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 2 0.0054 0.0313 0.0646
Echinococcus granulosus neuroglian 0.0049 0.0229 0.0229
Schistosoma mansoni tyrosine kinase 0.0451 0.6238 0.6238
Echinococcus granulosus cyclin 0.004 0.0096 0.0096
Echinococcus granulosus oligomeric golgi complex subunit 3 0.004 0.0096 0.0096
Schistosoma mansoni hexokinase 0.0096 0.094 0.094
Echinococcus multilocularis suppressor of cytokine signaling 7 0.0037 0.0056 0.0056
Plasmodium falciparum cAMP-dependent protein kinase catalytic subunit 0.0054 0.0313 0.1771
Schistosoma mansoni tyrosine kinase 0.0497 0.6917 0.6917
Trypanosoma cruzi developmentally regulated phosphoprotein, putative 0.0119 0.1277 0.365
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0037 0.0056 0.0056
Loa Loa (eye worm) hypothetical protein 0.0037 0.0056 0.0056
Trypanosoma cruzi cdc2-related kinase 3 0.01 0.0991 0.2815
Schistosoma mansoni adapter molecule crk 0.0051 0.0264 0.0264
Echinococcus granulosus protein kinase c iota type 0.0039 0.009 0.009
Brugia malayi cell division control protein 2 homolog 0.01 0.0991 0.0991
Brugia malayi SH2 domain containing protein 0.0037 0.0056 0.0056
Giardia lamblia Kinase, PLK 0.0108 0.1122 0.1795
Trichomonas vaginalis AGC family protein kinase 0.0056 0.0336 0.0547
Entamoeba histolytica serine/threonine protein kinase 6, putative 0.0126 0.1386 0.4566
Echinococcus granulosus raf serine:threonine protein kinase 0.0033 0.0005 0.0005
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.0062 0.0428 0.0991
Schistosoma mansoni serine/threonine protein kinase 0.0181 0.2205 0.2205
Trichomonas vaginalis cyclin B, putative 0.004 0.0096 0.0156
Brugia malayi Immunoglobulin I-set domain containing protein 0.0043 0.0141 0.0141
Brugia malayi hypothetical protein 0.0122 0.133 0.133
Echinococcus multilocularis cyclin dependent kinase 9 0.0067 0.0505 0.0505
Schistosoma mansoni cyclins 0.0144 0.1649 0.1649
Trypanosoma brucei protein kinase, putative 0.0073 0.0589 0.1468
Brugia malayi SH2 domain containing protein 0.0037 0.0056 0.0056
Trichomonas vaginalis STE family protein kinase 0.0116 0.123 0.2005
Echinococcus granulosus expressed conserved protein 0.0037 0.0056 0.0056
Trypanosoma brucei hexokinase 0.0096 0.094 0.2514
Echinococcus granulosus serine:threonine protein kinase TAO1 0.0202 0.2522 0.2522
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0037 0.0056 0.0056
Echinococcus granulosus cyclin dependent kinase 1 0.01 0.0991 0.0991
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0108 0.1122 0.1122
Brugia malayi RhoGAP domain containing protein 0.0043 0.0146 0.0146
Trichomonas vaginalis AGC family protein kinase 0.0056 0.0336 0.0547
Brugia malayi Protein kinase domain containing protein 0.0461 0.6384 0.6384
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0078 0.0673 0.0673
Loa Loa (eye worm) cyclin domain-containing protein 0.0275 0.361 0.361
Schistosoma mansoni nephrin 0.0049 0.0229 0.0229
Echinococcus multilocularis Cyclin L1 0.004 0.0096 0.0096
Brugia malayi cytokine inducible SH2-containing protein 5 0.0037 0.0056 0.0056
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0065 0.0472 0.1302
Schistosoma mansoni vav2 0.0045 0.0176 0.0176
Schistosoma mansoni tyrosine kinase 0.0704 1 1
Loa Loa (eye worm) SH2 domain-containing protein 0.0037 0.0056 0.0056
Schistosoma mansoni kinase 0.0059 0.0388 0.0388
Brugia malayi Immunoglobulin I-set domain containing protein 0.0246 0.3175 0.3175
Loa Loa (eye worm) AUR protein kinase 0.0126 0.1386 0.1386
Loa Loa (eye worm) TK/FER protein kinase 0.0064 0.0465 0.0465
Echinococcus granulosus cyclin k 0.004 0.0096 0.0096
Schistosoma mansoni serine/threonine protein kinase 0.022 0.2789 0.2789
Echinococcus granulosus CDC7 cell division cycle 7 0.0445 0.6136 0.6136
Echinococcus multilocularis proto oncogene serine:threonine protein kinase 0.0173 0.2086 0.2086
Echinococcus multilocularis mitogen activated protein kinase 3 0.0065 0.0472 0.0472
Schistosoma mansoni dual specificity serine/threonine tyrosine kinase 0.0086 0.0787 0.0787
Schistosoma mansoni serine/threonine protein kinase 0.0194 0.2394 0.2394
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.0043 0.0146 0.0146
Loa Loa (eye worm) cyclin fold protein 1 variant b 0.004 0.0096 0.0096
Leishmania major protein kinase, putative 0.0126 0.1386 0.384
Treponema pallidum hexokinase (hxk) 0.0096 0.094 0.5
Schistosoma mansoni pyruvate dehydrogenase 0.0112 0.1179 0.1179
Loa Loa (eye worm) hypothetical protein 0.0288 0.3799 0.3799
Trypanosoma brucei rac serine-threonine kinase, putative 0.0056 0.0336 0.0715
Trypanosoma cruzi cdc2-related kinase 1 0.01 0.0991 0.2815
Loa Loa (eye worm) AUR protein kinase 0.0126 0.1386 0.1386
Schistosoma mansoni tensin-related 0.0037 0.0056 0.0056
Entamoeba histolytica cyclin, putative 0.0237 0.3036 1
Echinococcus multilocularis Immunoglobulin 0.0043 0.0141 0.0141
Echinococcus granulosus cyclin B3 1 0.0144 0.1649 0.1649
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0062 0.0428 0.0428
Entamoeba histolytica cyclin C, putative 0.004 0.0096 0.0315
Trichomonas vaginalis cyclin B, putative 0.0237 0.3036 0.4947
Schistosoma mansoni tyrosine kinase 0.0469 0.6508 0.6508
Echinococcus multilocularis epidermal growth factor receptor 0.0497 0.6917 0.6917
Trypanosoma brucei mitotic cyclin 6 0.0237 0.3036 0.8749
Brugia malayi Hexokinase family protein 0.0096 0.094 0.094
Plasmodium falciparum cyclin 0.0144 0.1649 1
Echinococcus granulosus mitogen activated protein kinase 11 0.0265 0.3456 0.3456
Loa Loa (eye worm) hypothetical protein 0.0037 0.0056 0.0056
Trypanosoma cruzi polo-like protein kinase, putative 0.0108 0.1122 0.3196
Loa Loa (eye worm) hypothetical protein 0.0037 0.0056 0.0056
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0096 0.0206
Echinococcus multilocularis aurora kinase A 0.0126 0.1386 0.1386
Echinococcus multilocularis 0.0288 0.3795 0.3795
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0037 0.0056 0.0056
Echinococcus granulosus cyclin dependent kinase 5 activator 1 0.0255 0.3316 0.3316
Schistosoma mansoni protein kinase 0.0202 0.2523 0.2523
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0054 0.0313 0.0313
Entamoeba histolytica serine/threonine- protein kinase 6 , putative 0.0126 0.1386 0.4566
Echinococcus granulosus cyclins 0.0144 0.1649 0.1649
Onchocerca volvulus Serine\/threonine kinase homolog 0.0108 0.1122 0.1636
Schistosoma mansoni tyrosine kinase 0.0078 0.0673 0.0673
Entamoeba histolytica protein kinase domain containing protein 0.0062 0.0428 0.1411
Trichomonas vaginalis CAMK family protein kinase 0.0108 0.1122 0.1828
Echinococcus granulosus cyclins 0.0144 0.1649 0.1649
Echinococcus multilocularis SH2 motif 0.0037 0.0056 0.0056
Echinococcus granulosus tyrosine protein kinase Blk 0.0064 0.0465 0.0465
Echinococcus multilocularis serine:threonine protein kinase NIM1 0.0096 0.0941 0.0941
Trichomonas vaginalis AGC family protein kinase 0.0126 0.1386 0.2259
Entamoeba histolytica protein kinase , putative 0.0126 0.1386 0.4566
Brugia malayi intracellular kinase 0.0062 0.0428 0.0428
Echinococcus granulosus Protein kinase C brain isozyme 0.008 0.0696 0.0696
Trichomonas vaginalis CAMK family protein kinase 0.0108 0.1122 0.1828
Giardia lamblia Kinase, CMGC GSK 0.0062 0.0428 0.066
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0064 0.0465 0.0465
Brugia malayi hypothetical protein 0.0043 0.0141 0.0141
Loa Loa (eye worm) CMGC/CDK/CDK9 protein kinase 0.0059 0.0388 0.0388
Trichomonas vaginalis CMGC family protein kinase 0.0065 0.0472 0.0769
Trichomonas vaginalis CMGC family protein kinase 0.01 0.0991 0.1615
Echinococcus multilocularis tyrosine protein kinase Blk 0.0064 0.0465 0.0465
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0078 0.0673 0.0673
Brugia malayi Fibronectin type III domain containing protein 0.0043 0.0141 0.0141
Brugia malayi Cyclin C 0.004 0.0096 0.0096
Onchocerca volvulus 0.0096 0.094 0.1358
Schistosoma mansoni tyrosine-protein kinase zap-70 0.0037 0.0056 0.0056
Leishmania major protein kinase A catalytic subunit isoform 2 0.0054 0.0313 0.0646
Trypanosoma cruzi polo-like protein kinase, putative 0.0108 0.1122 0.3196
Loa Loa (eye worm) hypothetical protein 0.0043 0.0141 0.0141
Echinococcus multilocularis protein kinase shaggy 0.0062 0.0428 0.0428
Toxoplasma gondii hexokinase 0.0096 0.094 0.6546
Echinococcus multilocularis mitogen activated protein kinase 14 0.0265 0.3456 0.3456
Trichomonas vaginalis cyclin B3, putative 0.004 0.0096 0.0156
Brugia malayi SH2 domain containing protein 0.0064 0.0465 0.0465
Brugia malayi MAP kinase sur-1 0.0065 0.0472 0.0472
Onchocerca volvulus 0.0096 0.094 0.1358
Entamoeba histolytica protein kinase domain containing protein 0.0059 0.0388 0.1278
Trichomonas vaginalis cyclin B, putative 0.0237 0.3036 0.4947
Entamoeba histolytica hexokinase 1 0.0096 0.094 0.3097
Brugia malayi cell division control protein 2 homolog 0.0096 0.0941 0.0941
Plasmodium falciparum protein kinase, putative 0.0116 0.123 0.7419
Schistosoma mansoni serine/threonine-protein kinase 0.0037 0.0056 0.0056
Brugia malayi Protein kinase domain containing protein 0.0181 0.2205 0.2205
Echinococcus multilocularis CDC7 cell division cycle 7 0.0445 0.6136 0.6136
Echinococcus granulosus defective proboscis extension response 0.0043 0.0141 0.0141
Leishmania major CYC2-like cyclin, putative,cyclin 6, putative 0.0237 0.3036 0.8749
Trichomonas vaginalis CAMK family protein kinase 0.0116 0.1239 0.2019
Loa Loa (eye worm) PEK/PEK protein kinase 0.0202 0.2523 0.2523
Echinococcus granulosus cyclin B 0.0237 0.3036 0.3036
Echinococcus granulosus cyclin G2 0.004 0.0096 0.0096
Loa Loa (eye worm) CYL-1 protein 0.004 0.0096 0.0096
Echinococcus granulosus cyclin G2 0.004 0.0096 0.0096
Entamoeba histolytica PH domain containing protein kinase, putative 0.0037 0.0056 0.0183
Schistosoma mansoni serine/threonine protein kinase 0.0059 0.0388 0.0388
Plasmodium falciparum protein kinase 5 0.01 0.0991 0.5947
Loa Loa (eye worm) CDC7 protein kinase 0.0445 0.6136 0.6136
Loa Loa (eye worm) CMGC/MAPK/P38 protein kinase 0.0265 0.3456 0.3456
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0065 0.0472 0.1119
Loa Loa (eye worm) camk/mapkapk/mapkapk protein kinase 0.0194 0.2394 0.2394
Echinococcus multilocularis cyclin t1 0.004 0.0096 0.0096
Echinococcus multilocularis cyclins 0.0144 0.1649 0.1649
Echinococcus multilocularis cyclin dependent kinase 1 0.01 0.0991 0.0991
Echinococcus granulosus tyrosine kinase 0.0064 0.0465 0.0465
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0051 0.027 0.0889
Echinococcus granulosus cyclins 0.0144 0.1649 0.1649
Echinococcus multilocularis dual specificity testis specific protein kinase 0.0042 0.0129 0.0129
Echinococcus multilocularis signal transduction protein lnk realted 0.0037 0.0056 0.0056
Echinococcus granulosus serine threonine protein kinase nrc 0.0035 0.0025 0.0025
Giardia lamblia Kinase, CDC7 0.0445 0.6136 1
Trichomonas vaginalis cyclin B, putative 0.004 0.0096 0.0156
Entamoeba histolytica protein kinase, putative 0.0126 0.1386 0.4566
Trypanosoma cruzi CYC2-like cyclin, putative 0.0237 0.3036 0.8774
Echinococcus granulosus MAP kinase activated protein kinase 2 0.0194 0.2394 0.2394
Echinococcus granulosus protein kinase c epsilon type 0.004 0.0109 0.0109
Trypanosoma cruzi cyclin 9, putative 0.004 0.0096 0.0206
Echinococcus multilocularis SH2 domain containing protein 7 0.0037 0.0056 0.0056
Onchocerca volvulus 0.0064 0.0465 0.0628
Schistosoma mansoni SH2A 0.0037 0.0056 0.0056
Onchocerca volvulus Dual specificity protein kinase TTK homolog 0.0086 0.0787 0.1123
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0064 0.0465 0.0465
Loa Loa (eye worm) cyclin domain-containing protein 0.004 0.0096 0.0096
Loa Loa (eye worm) TK/FER protein kinase 0.0064 0.0465 0.0465
Loa Loa (eye worm) variant SH3 domain-containing protein 0.004 0.0105 0.0105
Trypanosoma cruzi cyclin, putative 0.0237 0.3036 0.8774
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0065 0.0472 0.1119
Loa Loa (eye worm) STAT protein 0.0037 0.0056 0.0056
Loa Loa (eye worm) TK/ROR protein kinase 0.0033 0.0003 0.0003
Brugia malayi Variant SH3 domain containing protein 0.004 0.0105 0.0105
Schistosoma mansoni tensin-related 0.0037 0.0056 0.0056
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0065 0.0472 0.1302
Trichomonas vaginalis CMGC family protein kinase 0.0065 0.0472 0.0769
Loa Loa (eye worm) hexokinase type II 0.0096 0.094 0.094
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0078 0.0673 0.0673
Plasmodium vivax cyclin homologue, putative 0.004 0.0096 0.0518
Schistosoma mansoni Cyclin fold protein 0.004 0.0096 0.0096
Onchocerca volvulus 0.0096 0.094 0.1358
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0043 0.0146 0.0146
Giardia lamblia Cyclin fold protein 1, putative 0.004 0.0096 0.0115
Echinococcus multilocularis hexokinase 0.0096 0.094 0.094
Toxoplasma gondii aurora kinase 0.0126 0.1386 1
Echinococcus multilocularis tyrosine kinase 0.0064 0.0465 0.0465
Trichomonas vaginalis CAMK family protein kinase 0.0108 0.1122 0.1828
Schistosoma mansoni serine/threonine protein kinase 0.0126 0.1386 0.1386
Echinococcus granulosus Immunoglobulin 0.0043 0.0141 0.0141
Echinococcus granulosus dual specificity serine:threonine tyrosine 0.0086 0.0787 0.0787
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.0043 0.0141 0.0141
Giardia lamblia Kinase, CMGC CDK 0.01 0.0991 0.1581
Schistosoma mansoni serine/threonine protein kinase 0.0202 0.2522 0.2522
Brugia malayi SH2 domain containing protein 0.0064 0.0465 0.0465
Trichomonas vaginalis CAMK family protein kinase 0.0086 0.0787 0.1283
Brugia malayi Tyrosine-protein kinase abl-1 0.0127 0.1403 0.1403
Loa Loa (eye worm) hypothetical protein 0.0043 0.0141 0.0141
Brugia malayi Protein kinase domain containing protein 0.0445 0.6136 0.6136
Brugia malayi Protein kinase domain containing protein 0.0064 0.0465 0.0465
Onchocerca volvulus Hexokinase homolog 0.006 0.0406 0.0537
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0096 0.0156
Echinococcus multilocularis telomerase reverse transcriptase subunit 0.0039 0.0093 0.0093
Echinococcus multilocularis cyclin b3 0.0144 0.1649 0.1649
Schistosoma mansoni suppressor of cytokine signaling 0.0037 0.0056 0.0056
Entamoeba histolytica cyclin, putative 0.0144 0.1649 0.5433
Schistosoma mansoni serine/threonine protein kinase 0.008 0.0696 0.0696
Onchocerca volvulus 0.0445 0.6136 0.9334
Echinococcus granulosus SH2 motif 0.0037 0.0056 0.0056
Schistosoma mansoni serine/threonine-protein kinase 0.0037 0.0056 0.0056
Toxoplasma gondii pyruvate dehydrogenase kinase, putative 0.0042 0.0125 0.0229
Trichomonas vaginalis cyclins, putative 0.004 0.0096 0.0156
Plasmodium vivax hexokinase, putative 0.0096 0.094 0.6725
Entamoeba histolytica protein kinase, putative 0.0051 0.027 0.0889
Echinococcus multilocularis rac serine:threonine kinase 0.0037 0.0056 0.0056
Echinococcus granulosus cyclin b3 0.0144 0.1649 0.1649
Loa Loa (eye worm) AUR protein kinase 0.0126 0.1386 0.1386
Entamoeba histolytica cell division protein kinase 2, putative 0.0107 0.1108 0.365
Echinococcus multilocularis Protein kinase C, brain isozyme 0.008 0.0696 0.0696
Brugia malayi protein kinase C II. 0.004 0.0109 0.0109
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0065 0.0472 0.1302
Echinococcus multilocularis hexokinase 0.0096 0.094 0.094
Entamoeba histolytica protein kinase, putative 0.0054 0.0305 0.1005
Loa Loa (eye worm) hypothetical protein 0.0043 0.0141 0.0141
Loa Loa (eye worm) hypothetical protein 0.0207 0.2588 0.2588
Onchocerca volvulus 0.004 0.0096 0.0061
Trypanosoma cruzi aurora B kinase, putative 0.0126 0.1386 0.3967
Entamoeba histolytica protein kinase domain containing protein 0.0062 0.0428 0.1411
Brugia malayi serine/threonine protein kinase 6 0.0126 0.1386 0.1386
Onchocerca volvulus 0.0172 0.2074 0.3099
Toxoplasma gondii calcium dependent protein kinase CDPK8 0.0042 0.0129 0.0261
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0108 0.1122 0.3053
Schistosoma mansoni hypothetical protein 0.004 0.0096 0.0096
Schistosoma mansoni tyrosine kinase 0.0469 0.6508 0.6508
Schistosoma mansoni protein kinase 0.0042 0.0129 0.0129
Schistosoma mansoni kinase 0.0062 0.043 0.043
Plasmodium vivax cyclin 4, putative 0.004 0.0096 0.0518
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.01 0.0991 0.0991
Echinococcus granulosus suppressor of cytokine signaling 7 0.0037 0.0056 0.0056
Trichomonas vaginalis cyclins, putative 0.0144 0.1649 0.2688
Schistosoma mansoni hypothetical protein 0.0037 0.0056 0.0056
Loa Loa (eye worm) hypothetical protein 0.0045 0.0183 0.0183
Echinococcus granulosus tensin 0.0037 0.0056 0.0056
Schistosoma mansoni tyrosine kinase 0.0043 0.0147 0.0147
Echinococcus granulosus hexokinase type 2 0.0096 0.094 0.094
Loa Loa (eye worm) cyclin domain-containing protein 0.004 0.0096 0.0096
Leishmania major developmentally regulated phosphoprotein-like protein 0.0119 0.1277 0.3517
Echinococcus multilocularis serine threonine protein kinase 0.0074 0.0606 0.0606
Loa Loa (eye worm) SRC-1 0.0078 0.0673 0.0673
Brugia malayi hypothetical protein 0.0064 0.0465 0.0465
Leishmania major protein kinase A catalytic subunit isoform 1 0.0054 0.0313 0.0646
Brugia malayi Protein kinase domain containing protein 0.0064 0.0465 0.0465
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0051 0.0264 0.0264
Onchocerca volvulus 0.0064 0.0465 0.0628
Echinococcus multilocularis raf serine:threonine protein kinase 0.0033 0.0005 0.0005
Schistosoma mansoni tyrosine kinase 0.0497 0.6917 0.6917
Loa Loa (eye worm) hypothetical protein 0.0039 0.0093 0.0093
Echinococcus multilocularis activin receptor type 0.0042 0.0129 0.0129
Giardia lamblia Kinase, TTK 0.0086 0.0787 0.1247
Schistosoma mansoni serine/threonine protein kinase 0.0173 0.2086 0.2086
Echinococcus granulosus tyrosine protein kinase Src64B 0.0078 0.0673 0.0673
Echinococcus granulosus activin receptor type 0.0042 0.0129 0.0129
Giardia lamblia Hypothetical protein 0.0144 0.1649 0.2658
Echinococcus multilocularis serine threonine protein kinase nrc serine threonine protein kinase gad 0.0035 0.0025 0.0025
Echinococcus granulosus twitchin 0.0063 0.0443 0.0443
Loa Loa (eye worm) hypothetical protein 0.0122 0.133 0.133
Brugia malayi Cyclin, N-terminal domain containing protein 0.004 0.0096 0.0096
Echinococcus granulosus tyrosine protein kinase Src42A 0.0078 0.0673 0.0673
Schistosoma mansoni cyclin-dependent kinase 5 activator 0.0255 0.3316 0.3316
Echinococcus granulosus cyclin t1 0.004 0.0096 0.0096
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.01 0.0991 0.6938
Trypanosoma cruzi cdc2-related kinase 1 0.01 0.0991 0.2815
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0096 0.0156
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.0062 0.0428 0.0428
Echinococcus granulosus cyclin A3 4 0.004 0.0096 0.0096
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0065 0.0472 0.1302
Echinococcus granulosus protein tyrosine kinase 0.0279 0.3662 0.3662
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.0062 0.0428 0.258
Echinococcus granulosus hexokinase 0.0096 0.094 0.094
Brugia malayi Tyrosine-protein kinase abl-1 0.0157 0.1847 0.1847
Loa Loa (eye worm) hypothetical protein 0.0052 0.0286 0.0286
Loa Loa (eye worm) SH2 domain-containing protein 0.0037 0.0056 0.0056
Echinococcus multilocularis cyclins 0.0144 0.1649 0.1649
Echinococcus multilocularis cyclin dependent kinase 0.01 0.0991 0.0991
Brugia malayi P38 map kinase family protein 2 0.0265 0.3456 0.3456
Plasmodium falciparum glycogen synthase kinase 3 0.0062 0.0428 0.2484
Brugia malayi Cyclin, N-terminal domain containing protein 0.0255 0.3306 0.3306
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0173 0.2086 0.2086
Giardia lamblia Kinase, CMGC GSK 0.0062 0.0428 0.066
Loa Loa (eye worm) hypothetical protein 0.0043 0.0142 0.0142
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.004 0.0109 0.0109
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.01 0.0991 0.2664
Trichomonas vaginalis CAMK family protein kinase 0.0108 0.1122 0.1828
Loa Loa (eye worm) TK/INSR protein kinase 0.0461 0.6384 0.6384
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0037 0.0056 0.0056
Echinococcus multilocularis SH2 motif 0.0037 0.0056 0.0056
Trypanosoma brucei polo-like protein kinase 0.0108 0.1122 0.3053
Schistosoma mansoni serine/threonine protein kinase 0.0054 0.0313 0.0313
Trichomonas vaginalis conserved hypothetical protein 0.0144 0.1649 0.2688
Loa Loa (eye worm) hypothetical protein 0.0037 0.0056 0.0056
Plasmodium vivax cyclin dependent kinase binding protein, putative 0.004 0.0096 0.0518
Brugia malayi Cyclin, N-terminal domain containing protein 0.004 0.0096 0.0096
Echinococcus multilocularis cyclin B 0.0237 0.3036 0.3036
Entamoeba histolytica PH domain containing protein kinase, putative 0.0056 0.0343 0.113
Loa Loa (eye worm) cyclin domain-containing protein 0.004 0.0096 0.0096
Brugia malayi Cyclin, N-terminal domain containing protein 0.004 0.0096 0.0096
Schistosoma mansoni vesicular amine transporter 0.0043 0.0141 0.0141
Echinococcus granulosus cyclins 0.0144 0.1649 0.1649
Loa Loa (eye worm) cyclin C 0.004 0.0096 0.0096
Leishmania major mitogen-activated protein kinase 3, putative,map kinase 3, putative 0.0265 0.3456 1
Loa Loa (eye worm) TK/FER protein kinase 0.0064 0.0465 0.0465
Loa Loa (eye worm) AGC/PKA protein kinase 0.0054 0.0313 0.0313
Brugia malayi Protein kinase domain containing protein 0.0173 0.2086 0.2086
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0096 0.0156
Leishmania major cyclin 0.0237 0.3036 0.8749
Echinococcus granulosus RNA directed DNA polymerase 0.0039 0.0093 0.0093
Entamoeba histolytica protein kinase, putative 0.0056 0.0336 0.1106
Leishmania major hexokinase, putative 0.0096 0.094 0.2514
Echinococcus granulosus SH2 domain containing adapter protein F 0.0037 0.0056 0.0056
Echinococcus multilocularis cyclin G2 0.004 0.0096 0.0096
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0173 0.2086 0.2086
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0037 0.0056 0.0056
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0078 0.0673 0.0673
Trichomonas vaginalis AGC family protein kinase 0.0126 0.1386 0.2259
Brugia malayi cyclin fold protein 1 variant b 0.004 0.0096 0.0096
Echinococcus multilocularis mitogen activated protein kinase 11 0.0265 0.3456 0.3456
Echinococcus multilocularis mitogen activated protein kinase 14 0.0265 0.3456 0.3456
Brugia malayi Serine/threonine-protein kinase SULU 0.0202 0.2522 0.2522
Loa Loa (eye worm) cyclin domain-containing protein 0.004 0.0096 0.0096
Onchocerca volvulus Cyclin L homolog 0.004 0.0096 0.0061
Echinococcus multilocularis cyclins 0.0144 0.1649 0.1649
Echinococcus granulosus cyclin dependent kinase 5 0.01 0.0991 0.0991
Plasmodium falciparum cyclin 1 0.004 0.0096 0.0434
Echinococcus multilocularis protein kinase c epsilon type 0.004 0.0109 0.0109
Echinococcus multilocularis enhancer of mRNA decapping protein 4 0.004 0.0098 0.0098
Loa Loa (eye worm) hypothetical protein 0.0052 0.0286 0.0286
Loa Loa (eye worm) hypothetical protein 0.0051 0.0264 0.0264
Trichomonas vaginalis cyclin B, putative 0.0237 0.3036 0.4947
Plasmodium vivax serine/threonine-specific protein kinase, putative 0.0116 0.123 0.8854
Echinococcus granulosus NCK adaptor protein 0.0051 0.0264 0.0264
Loa Loa (eye worm) hypothetical protein 0.0037 0.0056 0.0056
Onchocerca volvulus 0.0064 0.0465 0.0628
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0078 0.0673 0.0673
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0497 0.6917 0.6917
Echinococcus granulosus cyclin y 0.004 0.0096 0.0096
Schistosoma mansoni serine/threonine protein kinase 0.0096 0.0941 0.0941
Echinococcus multilocularis NCK adaptor protein 0.0051 0.0264 0.0264
Echinococcus multilocularis cyclin y 0.004 0.0096 0.0096
Trypanosoma cruzi mitotic cyclin, putative 0.004 0.0096 0.0206
Schistosoma mansoni cyclin l 0.004 0.0096 0.0096
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.0126 0.1383 0.1383
Echinococcus granulosus aurora kinase A 0.0126 0.1386 0.1386
Echinococcus multilocularis G2:mitotic specific cyclin B3 0.0255 0.3306 0.3306
Trichomonas vaginalis AGC family protein kinase 0.0035 0.0031 0.005
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0054 0.0313 0.0313
Echinococcus granulosus cyclin dependent kinase 0.01 0.0991 0.0991
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.0062 0.0428 0.0428
Loa Loa (eye worm) hypothetical protein 0.0037 0.0056 0.0056
Trichomonas vaginalis CAMK family protein kinase 0.0086 0.0787 0.1283
Onchocerca volvulus 0.0062 0.0428 0.0572
Trypanosoma brucei protein kinase, putative 0.0062 0.0428 0.0991
Brugia malayi protein-tyrosine kinase 0.0064 0.0465 0.0465
Brugia malayi serine/threonine kinase 12 0.0126 0.1386 0.1386
Trypanosoma cruzi cyclin 6, putative 0.0237 0.3036 0.8774
Brugia malayi Cyclin, N-terminal domain containing protein 0.004 0.0096 0.0096
Trichomonas vaginalis CAMK family protein kinase 0.0061 0.0411 0.0671
Echinococcus multilocularis mitogen activated protein kinase 0.0065 0.0472 0.0472
Schistosoma mansoni GTPase activating protein 0.0037 0.0056 0.0056
Echinococcus granulosus tyrosine protein kinase shark 0.0488 0.6788 0.6788
Echinococcus granulosus tyrosine protein kinase Lyn 0.0093 0.0887 0.0887
Echinococcus granulosus tyrosine kinase 0.0064 0.0465 0.0465
Brugia malayi Protein kinase domain containing protein 0.0262 0.3418 0.3418
Trichomonas vaginalis AGC family protein kinase 0.0054 0.0313 0.0509
Schistosoma mansoni protein kinase 0.0042 0.0129 0.0129
Schistosoma mansoni tensin 0.0037 0.0056 0.0056
Loa Loa (eye worm) AGC/AKT protein kinase 0.0056 0.0336 0.0336
Echinococcus multilocularis cyclins 0.0144 0.1649 0.1649
Brugia malayi hypothetical protein 0.0037 0.0056 0.0056
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0265 0.3456 1
Brugia malayi STAT protein, DNA binding domain containing protein 0.0037 0.0056 0.0056
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.01 0.0991 0.0991
Echinococcus multilocularis cyclin 0.004 0.0096 0.0096
Onchocerca volvulus 0.0445 0.6136 0.9334
Echinococcus multilocularis epidermal growth factor receptor 0.0704 1 1
Trypanosoma brucei aurora B kinase 0.0126 0.1386 0.384
Echinococcus granulosus serine threonine protein kinase 0.0116 0.123 0.123
Onchocerca volvulus 0.0096 0.0941 0.1358
Schistosoma mansoni serine/threonine protein kinase 0.01 0.0991 0.0991
Loa Loa (eye worm) TK/ABL protein kinase 0.027 0.3536 0.3536
Trichomonas vaginalis CMGC family protein kinase 0.0445 0.6136 1
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.01 0.0991 0.0991
Loa Loa (eye worm) TK/FER protein kinase 0.0064 0.0465 0.0465
Trypanosoma brucei STE/STE11 serine/threonine-protein kinase, putative 0.0042 0.0129 0.01
Trichomonas vaginalis cyclins, putative 0.0237 0.3036 0.4947
Echinococcus granulosus tyrosine protein kinase Fyn 0.0078 0.0673 0.0673
Brugia malayi kinase, mitochondrial precursor 0.0119 0.1277 0.1277
Trypanosoma brucei hexokinase 0.0096 0.094 0.2514
Loa Loa (eye worm) hypothetical protein 0.0037 0.0056 0.0056
Schistosoma mansoni growth factor receptor-bound protein 0.0051 0.0264 0.0264
Toxoplasma gondii AGC kinase 0.0054 0.0313 0.1682
Echinococcus granulosus hypothetical protein 0.0037 0.0056 0.0056
Trichomonas vaginalis CAMK family protein kinase 0.0061 0.0411 0.0671
Brugia malayi cyclin-dependent kinase 9 0.0059 0.0388 0.0388
Schistosoma mansoni cell adhesion molecule 0.0046 0.0197 0.0197
Onchocerca volvulus 0.0237 0.3036 0.4574
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0064 0.0465 0.0465
Echinococcus granulosus roundabout 2 0.0052 0.0286 0.0286
Onchocerca volvulus Serine\/threonine protein kinase homolog 0.0173 0.2086 0.3117
Echinococcus granulosus serine:threonine protein kinase NIM1 0.0096 0.0941 0.0941
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0054 0.0313 0.0313
Brugia malayi Protein kinase domain containing protein 0.0282 0.3707 0.3707
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0033 0.0003 0.0003
Echinococcus multilocularis tensin 0.0037 0.0056 0.0056
Echinococcus multilocularis dual specificity serine:threonine tyrosine 0.0086 0.0787 0.0787
Loa Loa (eye worm) hypothetical protein 0.0237 0.3036 0.3036
Echinococcus multilocularis growth factor receptor bound protein 2 0.0051 0.0264 0.0264
Entamoeba histolytica cyclin, domain containing protein 0.004 0.0096 0.0315
Echinococcus granulosus glycogen synthase kinase 3 beta 0.0062 0.0428 0.0428
Schistosoma mansoni cyclin G 0.004 0.0096 0.0096
Entamoeba histolytica cell division protein kinase 2, putative 0.01 0.0991 0.3264
Brugia malayi hypothetical protein 0.004 0.0096 0.0096
Echinococcus multilocularis fibroblast growth factor receptor 4 0.0126 0.1383 0.1383
Echinococcus granulosus enhancer of mRNA decapping protein 4 0.004 0.0098 0.0098
Echinococcus multilocularis hexokinase 0.0096 0.094 0.094
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0037 0.0056 0.0056
Schistosoma mansoni serine/threonine protein kinase 0.01 0.0991 0.0991
Chlamydia trachomatis serine/threonine protein kinase 0.022 0.2789 0.5
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0042 0.0129 0.0304
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0054 0.0313 0.0313
Entamoeba histolytica protein kinase, putative 0.0056 0.0336 0.1106
Echinococcus granulosus c src tyrosine kinase 0.0078 0.0673 0.0673
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0108 0.1122 0.1122
Echinococcus granulosus proto oncogene serine:threonine protein kinase 0.0173 0.2086 0.2086
Entamoeba histolytica cyclin, domain containing protein 0.004 0.0096 0.0315
Echinococcus multilocularis protein kinase c iota type 0.0039 0.009 0.009
Brugia malayi Protein kinase domain containing protein 0.0056 0.0336 0.0336
Trichomonas vaginalis CAMK family protein kinase 0.0108 0.1122 0.1828
Trypanosoma cruzi pyruvate dehydrogenase (lipoamide) kinase, putative 0.0042 0.0125 0.0292
Plasmodium falciparum serine/threonine protein kinase, putative 0.0126 0.1386 0.8379
Echinococcus granulosus suppressor of cytokine signaling 6 0.0037 0.0056 0.0056
Brugia malayi Serine/threonine-protein kinase Nek7 0.022 0.2789 0.2789
Toxoplasma gondii AGC kinase 0.0054 0.0313 0.1682
Trypanosoma cruzi cdc2-related kinase 3 0.01 0.0991 0.2815
Brugia malayi Serine/threonine-protein kinase Pim-3 0.0173 0.2086 0.2086
Trypanosoma cruzi Protein kinase B 0.0037 0.0056 0.0089
Echinococcus multilocularis cyclin A3 4 0.004 0.0096 0.0096
Loa Loa (eye worm) hypothetical protein 0.0064 0.0465 0.0465
Loa Loa (eye worm) hypothetical protein 0.0122 0.133 0.133
Loa Loa (eye worm) hypothetical protein 0.0046 0.0197 0.0197
Leishmania major pyruvate dehydrogenase (lipoamide) kinase, putative 0.0042 0.0125 0.0088
Brugia malayi Cyclin, N-terminal domain containing protein 0.0275 0.361 0.361
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.0119 0.1277 0.1277
Trichomonas vaginalis cyclin D, putative 0.0144 0.1649 0.2688
Loa Loa (eye worm) hypothetical protein 0.0043 0.0141 0.0141
Trichomonas vaginalis CMGC family protein kinase 0.0065 0.0472 0.0769
Trichomonas vaginalis AGC family protein kinase 0.0126 0.1386 0.2259
Echinococcus multilocularis MAP kinase activated protein kinase 2 0.0194 0.2394 0.2394
Schistosoma mansoni growth factor receptor-bound protein 0.0051 0.0264 0.0264
Echinococcus granulosus serine:threonine protein kinase PAK 4 0.0181 0.2204 0.2204
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 1 0.0054 0.0313 0.0646
Schistosoma mansoni tyrosine kinase 0.0461 0.6384 0.6384
Entamoeba histolytica protein kinase, putative 0.0062 0.0428 0.1411
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0078 0.0673 0.0673
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0078 0.0673 0.0673
Loa Loa (eye worm) TK/FER protein kinase 0.0064 0.0465 0.0465
Giardia lamblia Aurora kinase 0.0126 0.1386 0.2227
Schistosoma mansoni protein kinase 0.0126 0.1386 0.1386
Plasmodium falciparum protein kinase, putative 0.0042 0.0129 0.0641
Trypanosoma cruzi hexokinase, putative 0.0096 0.094 0.2668
Echinococcus granulosus cdk5 and abl1 enzyme substrate 1 0.004 0.0096 0.0096
Brugia malayi Cyclin, N-terminal domain containing protein 0.004 0.0096 0.0096
Echinococcus granulosus mitogen activated protein kinase 0.0065 0.0472 0.0472
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0065 0.0472 0.1119
Entamoeba histolytica hypothetical protein 0.004 0.0096 0.0315
Toxoplasma gondii AGC kinase 0.0054 0.0305 0.1625
Trichomonas vaginalis CMGC family protein kinase 0.0062 0.0428 0.0698
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.0126 0.1383 0.1383
Loa Loa (eye worm) TK protein kinase 0.0132 0.1471 0.1471
Giardia lamblia G2/mitotic-specific cyclin B 0.0237 0.3036 0.4926
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0051 0.0264 0.0264
Echinococcus multilocularis SH2 domain containing adapter protein F 0.0037 0.0056 0.0056
Loa Loa (eye worm) SH2 domain-containing protein 0.0037 0.0056 0.0056
Schistosoma mansoni cyclin G2 0.004 0.0096 0.0096
Trichomonas vaginalis cyclin D, putative 0.004 0.0096 0.0156
Echinococcus multilocularis serine:threonine protein kinase 12 B 0.0126 0.1386 0.1386
Trypanosoma brucei pyruvate dehydrogenase (lipoamide) kinase, putative 0.0042 0.0125 0.0088
Schistosoma mansoni pyruvate dehydrogenase 0.0112 0.1179 0.1179
Schistosoma mansoni serine/threonine protein kinase 0.0108 0.1122 0.1122
Loa Loa (eye worm) TTK protein kinase 0.0086 0.0787 0.0787
Schistosoma mansoni cyclin B 0.0237 0.3036 0.3036
Brugia malayi SH2 domain containing protein 0.0037 0.0056 0.0056
Echinococcus multilocularis cyclin B3 1 0.0144 0.1649 0.1649
Echinococcus multilocularis insulin receptor 0.0461 0.6384 0.6384
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0078 0.0673 0.0673
Echinococcus multilocularis cyclin dependent kinase 9 0.0059 0.0388 0.0388
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0033 0.0003 0.0003
Trichomonas vaginalis AGC family protein kinase 0.0126 0.1386 0.2259
Onchocerca volvulus 0.0064 0.0465 0.0628
Loa Loa (eye worm) hexokinase 0.006 0.0406 0.0406
Loa Loa (eye worm) hypothetical protein 0.0255 0.3316 0.3316
Echinococcus multilocularis tyrosine protein kinase Abl 0.0157 0.1847 0.1847
Trichomonas vaginalis CAMK family protein kinase 0.0108 0.1122 0.1828
Brugia malayi SH2 domain containing protein 0.0037 0.0056 0.0056
Entamoeba histolytica SH2 domain containing protein 0.0037 0.0056 0.0184
Brugia malayi SH2 domain containing protein 0.0037 0.0056 0.0056
Brugia malayi Protein kinase domain containing protein 0.0064 0.0465 0.0465
Echinococcus granulosus dual specificity testis-specific protein kinase 0.0042 0.0129 0.0129
Echinococcus granulosus cyclin dependent kinase 9 0.0059 0.0388 0.0388
Trichomonas vaginalis AGC family protein kinase 0.0056 0.0336 0.0547
Schistosoma mansoni serine/threonine protein kinase 0.0116 0.123 0.123
Brugia malayi Protein kinase c protein 2 0.0061 0.0416 0.0416
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.0054 0.0313 0.0838
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.0051 0.0264 0.0264
Echinococcus granulosus signal transduction protein lnk realted 0.0037 0.0056 0.0056
Brugia malayi Immunoglobulin I-set domain containing protein 0.0132 0.1471 0.1471

Activities

Activity type Activity value Assay description Source Reference
EC50 (binding) = 0.25 uM Activation of flag-tagged human recombinant liver glucokinase expressed in Escherichia coli by glucose-6-phosphate dehydrogenase coupled continuous spectrophotometric assay in presence of 10 mM glucose ChEMBL. 19427223
EC50 (binding) = 0.75 uM Activation of flag-tagged human recombinant liver glucokinase expressed in Escherichia coli by glucose-6-phosphate dehydrogenase coupled continuous spectrophotometric assay in presence of 2.5 mM glucose ChEMBL. 19427223

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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