Detailed information for compound 1048162

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 366.54 | Formula: C24H34N2O
  • H donors: 1 H acceptors: 1 LogP: 6.29 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCCc1ccc(cc1)c1occ(n1)CN[C@@H]1C[C@@H]2C[C@H]([C@H]1C)C2(C)C
  • InChi: 1S/C24H34N2O/c1-5-6-7-17-8-10-18(11-9-17)23-26-20(15-27-23)14-25-22-13-19-12-21(16(22)2)24(19,3)4/h8-11,15-16,19,21-22,25H,5-7,12-14H2,1-4H3/t16-,19+,21-,22-/m1/s1
  • InChiKey: GFXRNZLIXAPNDA-DGEVVOEJSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.0295 0.0038 0.0062
Echinococcus granulosus titin 0.0334 0.0082 0.0143
Onchocerca volvulus Tyrosine kinase homolog 0.2631 0.2705 0.3475
Echinococcus multilocularis casein kinase I alpha 0.0506 0.0279 0.0274
Schistosoma mansoni serine/threonine protein kinase 0.0266 0.0005 0.0013
Echinococcus granulosus cyclin dependent kinase 9 0.0355 0.0106 0.0187
Plasmodium falciparum calcium-dependent protein kinase 2 0.0453 0.0218 0.2435
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0453 0.0218 0.0276
Loa Loa (eye worm) AGC/NDR protein kinase 0.0391 0.0148 0.0185
Onchocerca volvulus 0.0401 0.0159 0.0172
Loa Loa (eye worm) hypothetical protein 0.0606 0.0394 0.0503
Brugia malayi Immunoglobulin I-set domain containing protein 0.0613 0.0401 0.0513
Echinococcus granulosus serine:threonine protein kinase 12 B 0.0522 0.0298 0.0539
Trypanosoma brucei STE/STE11 serine/threonine-protein kinase, putative 0.0349 0.01 0.0205
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.1032 0.088 0.222
Echinococcus granulosus protein kinase C gamma type 0.0391 0.0148 0.0264
Brugia malayi hypothetical protein 0.06 0.0386 0.0493
Trichomonas vaginalis AGC family protein kinase 0.0522 0.0298 0.2643
Trichomonas vaginalis AGC family protein kinase 0.043 0.0192 0.1689
Echinococcus granulosus casein kinase i 0.0506 0.0279 0.0505
Brugia malayi Protein kinase domain containing protein 0.2159 0.2167 0.2796
Brugia malayi Protein kinase domain containing protein 0.0737 0.0543 0.0696
Echinococcus multilocularis cyclin dependent kinase 1 0.0345 0.0096 0.0091
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.028 0.0021 0.003
Schistosoma mansoni serine/threonine protein kinase 0.0527 0.0303 0.0764
Entamoeba histolytica PH domain containing protein kinase, putative 0.0686 0.0485 0.5032
Loa Loa (eye worm) hypothetical protein 0.0789 0.0603 0.0773
Onchocerca volvulus 0.0401 0.0159 0.0172
Entamoeba histolytica protein kinase, putative 0.0324 0.0072 0.074
Trypanosoma brucei protein kinase, putative 0.0349 0.01 0.0205
Schistosoma mansoni nck2/grb4 0.0335 0.0084 0.0213
Leishmania major mitogen-activated protein kinase kinase 5, putative;with=GeneDB:LmxM36.0860 0.1236 0.1112 0.2384
Loa Loa (eye worm) hypothetical protein 0.0836 0.0656 0.0841
Schistosoma mansoni vesicular amine transporter 0.059 0.0375 0.0946
Entamoeba histolytica casein kinase, putative 0.0506 0.0279 0.2895
Echinococcus multilocularis beta adrenergic receptor kinase 0.0271 0.0011 0.0006
Schistosoma mansoni protein kinase 0.0929 0.0763 0.1924
Giardia lamblia Kinase, CMGC CDK 0.0345 0.0096 0.0623
Entamoeba histolytica protein kinase, putative 0.0313 0.0059 0.0607
Plasmodium falciparum serine/threonine protein kinase, putative 0.0522 0.0298 0.3343
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0648 0.0441 0.0436
Echinococcus granulosus tyrosine kinase 0.0779 0.0591 0.108
Echinococcus multilocularis 0.0786 0.0599 0.0594
Echinococcus granulosus p21 activated protein kinase 1 Dpak1 0.0286 0.0028 0.0042
Echinococcus granulosus serine:threonine protein kinase MARK2 0.0344 0.0094 0.0164
Echinococcus granulosus tyrosine protein kinase Fyn 0.0932 0.0766 0.1402
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0779 0.0591 0.0586
Echinococcus granulosus aurora kinase A 0.0522 0.0298 0.0539
Trypanosoma brucei rac serine-threonine kinase, putative 0.043 0.0192 0.0403
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0932 0.0766 0.0761
Echinococcus multilocularis serine:threonine protein kinase PAK 3 0.0286 0.0028 0.0023
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0453 0.0218 0.0276
Trichomonas vaginalis AGC family protein kinase 0.0522 0.0298 0.2643
Echinococcus multilocularis Immunoglobulin 0.0584 0.0369 0.0364
Onchocerca volvulus 0.0424 0.0185 0.0207
Giardia lamblia Kinase, CMGC GSK 0.1032 0.088 0.7862
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 2 0.0648 0.0441 0.0938
Echinococcus granulosus insulin growth factor 1 receptor beta 0.1024 0.087 0.1595
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.1032 0.088 0.0876
Giardia lamblia Kinase, AGC AKT 0.0882 0.0709 0.628
Entamoeba histolytica protein kinase, putative 0.1104 0.0963 1
Echinococcus multilocularis casein kinase I alpha 0.0506 0.0279 0.0274
Onchocerca volvulus 0.0293 0.0036 0.0013
Schistosoma mansoni titin 0.0334 0.0082 0.0208
Entamoeba histolytica protein kinase domain containing protein 0.1104 0.0963 1
Trichomonas vaginalis CK1 family protein kinase 0.0506 0.0279 0.2474
Plasmodium falciparum cAMP-dependent protein kinase catalytic subunit 0.0648 0.0441 0.498
Schistosoma mansoni protein kinase 0.0506 0.0279 0.0704
Echinococcus multilocularis raf serine:threonine protein kinase 0.0331 0.008 0.0075
Plasmodium falciparum protein serine/threonine kinase-1 0.091 0.074 0.8402
Trypanosoma cruzi Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative 0.06 0.0386 0.0821
Brugia malayi cAMP-dependent protein kinase catalytic subunit, putative 0.0648 0.0441 0.0564
Loa Loa (eye worm) TK/FAK protein kinase 0.3776 0.4012 0.5183
Trichomonas vaginalis STE family protein kinase 0.1236 0.1112 1
Schistosoma mansoni tyrosine kinase 0.035 0.0101 0.0255
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.2275 0.2299 0.2295
Brugia malayi Variant SH3 domain containing protein 0.0295 0.0038 0.0043
Brugia malayi Protein kinase domain containing protein 0.0401 0.0159 0.0199
Echinococcus granulosus TGF-beta receptor type-1 0.0842 0.0663 0.1212
Echinococcus granulosus hypothetical protein 0.0779 0.0591 0.108
Schistosoma mansoni serine/threonine protein kinase 0.1143 0.1006 0.2539
Trichomonas vaginalis CK1 family protein kinase 0.0506 0.0279 0.2474
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.1531 0.1449 0.1868
Echinococcus granulosus mitogen activated protein kinase 14 0.4334 0.465 0.8562
Brugia malayi Protein kinase domain containing protein 0.1873 0.184 0.2373
Schistosoma mansoni hypothetical protein 0.0337 0.0086 0.0216
Brugia malayi Protein kinase domain containing protein 0.0401 0.0159 0.0199
Brugia malayi protein C17H12.11 0.0607 0.0394 0.0503
Schistosoma mansoni serine/threonine protein kinase 0.0591 0.0376 0.0948
Giardia lamblia Aurora kinase 0.0522 0.0298 0.2487
Echinococcus multilocularis serine:threonine protein kinase N2 0.0391 0.0148 0.0143
Loa Loa (eye worm) TK protein kinase 0.0597 0.0383 0.0488
Echinococcus granulosus tyrosine protein kinase shark 0.0401 0.0159 0.0283
Loa Loa (eye worm) hypothetical protein 0.0427 0.0189 0.0238
Loa Loa (eye worm) hypothetical protein 0.0584 0.0369 0.047
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.1104 0.0963 0.2061
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0568 0.035 0.0636
Echinococcus multilocularis calcium dependent protein kinase 0.0322 0.0069 0.0064
Schistosoma mansoni tyrosine kinase 0.035 0.0101 0.0255
Loa Loa (eye worm) TK/FER protein kinase 0.0401 0.0159 0.0199
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0932 0.0766 0.0761
Loa Loa (eye worm) hypothetical protein 0.108 0.0934 0.1202
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0731 0.0536 0.0531
Schistosoma mansoni kinase 0.0355 0.0106 0.0268
Brugia malayi ribosomal protein S6 kinase alpha 3 0.0882 0.0709 0.091
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0345 0.0096 0.0117
Brugia malayi casein kinase 1, delta 0.0506 0.0279 0.0354
Schistosoma mansoni hypothetical protein 0.06 0.0386 0.0974
Schistosoma mansoni protein kinase 0.0349 0.01 0.0252
Echinococcus multilocularis receptor type tyrosine protein phosphatase F 0.028 0.0021 0.0016
Trypanosoma brucei cdc2-related kinase 3 0.0345 0.0096 0.0195
Echinococcus multilocularis tyrosine protein kinase Abl 0.1259 0.1139 0.1134
Schistosoma mansoni tyrosine kinase 0.0568 0.035 0.0883
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0648 0.0441 0.0803
Echinococcus multilocularis tyrosine kinase 0.0401 0.0159 0.0154
Schistosoma mansoni tyrosine kinase 0.3734 0.3965 1
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.1391 0.129 0.1661
Echinococcus granulosus tyrosine protein kinase ABL1 0.2245 0.2264 0.4164
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.028 0.0021 0.0016
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0295 0.0038 0.0097
Echinococcus multilocularis aurora kinase A 0.0522 0.0298 0.0293
Loa Loa (eye worm) IKK protein kinase 0.7038 0.7737 1
Echinococcus multilocularis casein kinase i 0.0506 0.0279 0.0274
Trichomonas vaginalis CMGC family protein kinase 0.0345 0.0096 0.0818
Echinococcus multilocularis fibroblast growth factor receptor 4 0.12 0.1072 0.1068
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.1032 0.088 0.1884
Schistosoma mansoni serine/threonine protein kinase 0.0504 0.0277 0.07
Echinococcus granulosus contactin 0.028 0.0021 0.003
Echinococcus granulosus roundabout 2 0.028 0.0021 0.003
Schistosoma mansoni tyrosine kinase 0.0932 0.0766 0.1931
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0453 0.0218 0.2027
Brugia malayi Protein kinase domain containing protein 0.0425 0.0186 0.0235
Onchocerca volvulus 0.2238 0.2257 0.2894
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0453 0.0218 0.0213
Loa Loa (eye worm) hypothetical protein 0.0758 0.0566 0.0726
Schistosoma mansoni serine/threonine protein kinase 0.1418 0.132 0.333
Brugia malayi Protein kinase domain containing protein 0.0645 0.0438 0.056
Plasmodium vivax glycogen synthase kinase 3, putative 0.1032 0.088 1
Echinococcus multilocularis PAK box P21 Rho binding 0.0286 0.0028 0.0023
Loa Loa (eye worm) hypothetical protein 0.06 0.0386 0.0493
Schistosoma mansoni serine/threonine protein kinase 0.0391 0.0148 0.0374
Brugia malayi Protein kinase domain containing protein 0.0391 0.0148 0.0185
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0313 0.0059 0.0607
Entamoeba histolytica protein kinase, putative 0.0453 0.0218 0.2264
Entamoeba histolytica casein kinase 1, putative 0.0506 0.0279 0.2895
Loa Loa (eye worm) hypothetical protein 0.0661 0.0457 0.0584
Loa Loa (eye worm) STE/STE7/MEK1 protein kinase 0.1236 0.1112 0.1432
Entamoeba histolytica cell division protein kinase 2, putative 0.0345 0.0096 0.0989
Brugia malayi protein kinase C II. 0.0504 0.0277 0.0352
Brugia malayi Sex muscle abnormal protein 5 0.0335 0.0084 0.0103
Echinococcus granulosus neuropeptide s receptor 0.0542 0.032 0.0581
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0392 0.015 0.0145
Onchocerca volvulus 0.06 0.0386 0.0468
Echinococcus granulosus tyrosine kinase 0.0401 0.0159 0.0283
Loa Loa (eye worm) hypothetical protein 0.0719 0.0523 0.067
Echinococcus granulosus Serine/threonine-protein kinase Genghis Khan 0.0843 0.0665 0.1216
Brugia malayi Immunoglobulin I-set domain containing protein 0.028 0.0021 0.0021
Brugia malayi Fibronectin type III domain containing protein 0.0613 0.0401 0.0513
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.0391 0.0148 0.0185
Loa Loa (eye worm) hypothetical protein 0.0337 0.0086 0.0104
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0453 0.0218 0.2027
Schistosoma mansoni serine/threonine protein kinase 0.0504 0.0277 0.07
Schistosoma mansoni serine/threonine protein kinase 0.0591 0.0376 0.0948
Echinococcus multilocularis serine threonine protein kinase 0.0391 0.0148 0.0143
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0648 0.0441 0.0803
Brugia malayi Protein kinase domain containing protein 0.0391 0.0148 0.0185
Loa Loa (eye worm) hypothetical protein 0.06 0.0386 0.0493
Echinococcus multilocularis casein kinase I delta 0.0506 0.0279 0.0274
Leishmania major protein kinase A catalytic subunit isoform 2 0.0648 0.0441 0.0938
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0453 0.0218 0.2027
Echinococcus multilocularis roundabout 2 0.028 0.0021 0.0016
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0504 0.0277 0.0272
Leishmania major protein kinase, putative 0.0522 0.0298 0.063
Echinococcus multilocularis cyclin dependent kinase 7 0.0591 0.0376 0.0371
Echinococcus multilocularis G protein coupled receptor kinase 6 0.1391 0.129 0.1285
Loa Loa (eye worm) TK/FER protein kinase 0.0401 0.0159 0.0199
Echinococcus granulosus casein kinase I alpha 0.0506 0.0279 0.0505
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0349 0.01 0.0205
Echinococcus multilocularis neuroglian 0.028 0.0021 0.0016
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0932 0.0766 0.0761
Leishmania major protein kinase, putative 0.0349 0.01 0.0205
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0932 0.0766 0.0761
Toxoplasma gondii AGC kinase 0.0391 0.0148 0.1638
Trichomonas vaginalis CMGC family protein kinase 0.1032 0.088 0.7906
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.0391 0.0148 0.0264
Onchocerca volvulus 0.0401 0.0159 0.0172
Brugia malayi P38 map kinase family protein 2 0.4334 0.465 0.6007
Echinococcus granulosus tyrosine protein kinase Srms 0.0401 0.0159 0.0283
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 2 0.0648 0.0441 0.0938
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.0391 0.0148 0.0143
Schistosoma mansoni serine/threonine protein kinase 0.0345 0.0096 0.0241
Schistosoma mansoni serine/threonine protein kinase 0.0344 0.0094 0.0237
Loa Loa (eye worm) hypothetical protein 0.06 0.0386 0.0493
Loa Loa (eye worm) CAMK protein kinase 0.0334 0.0082 0.01
Brugia malayi SH2 domain containing protein 0.0401 0.0159 0.0199
Trichomonas vaginalis STE family protein kinase 0.0286 0.0028 0.0208
Echinococcus granulosus NCK adaptor protein 0.0335 0.0084 0.0146
Echinococcus granulosus insulin receptor 0.0995 0.0838 0.1535
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.0335 0.0084 0.0213
Brugia malayi Phorbol esters/diacylglycerol binding domain 0.085 0.0672 0.0863
Echinococcus multilocularis protein kinase c iota type 0.0504 0.0277 0.0272
Loa Loa (eye worm) TKL/LRRK protein kinase 0.0425 0.0186 0.0235
Echinococcus multilocularis 0.0779 0.0591 0.0586
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0392 0.015 0.0267
Loa Loa (eye worm) AGC/PKA protein kinase 0.0648 0.0441 0.0564
Brugia malayi Immunoglobulin I-set domain containing protein 0.028 0.0021 0.0021
Loa Loa (eye worm) hypothetical protein 0.4406 0.4732 0.6113
Echinococcus granulosus roundabout 2 0.0864 0.0688 0.126
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.1104 0.0963 0.2061
Plasmodium falciparum protein kinase 5 0.0345 0.0096 0.1034
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.1104 0.0963 0.2061
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0575 0.0358 0.0353
Schistosoma mansoni serine/threonine protein kinase 0.1873 0.184 0.4641
Giardia lamblia Kinase, STE STE20 0.1236 0.1112 1
Schistosoma mansoni serine/threonine protein kinase 0.0648 0.0441 0.1112
Loa Loa (eye worm) hypothetical protein 0.0613 0.0401 0.0513
Schistosoma mansoni protein kinase 0.0349 0.01 0.0252
Echinococcus multilocularis cyclin dependent kinase 9 0.0355 0.0106 0.0101
Echinococcus granulosus serine:threonine protein kinase N2 0.1026 0.0874 0.1601
Brugia malayi hypothetical protein 0.0613 0.0401 0.0513
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0932 0.0766 0.0761
Schistosoma mansoni tyrosine kinase 0.0995 0.0838 0.2113
Echinococcus granulosus raf serine:threonine protein kinase 0.0331 0.008 0.0138
Echinococcus granulosus twitchin 0.0889 0.0717 0.1312
Loa Loa (eye worm) CAMK/CAMKL/AMPK protein kinase 0.0843 0.0663 0.0852
Loa Loa (eye worm) CMGC/CDK/CDK9 protein kinase 0.0355 0.0106 0.0131
Echinococcus multilocularis GTPase activating Rap:RanGAP domain 3 0.06 0.0386 0.0381
Loa Loa (eye worm) hypothetical protein 0.0613 0.0401 0.0513
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.0648 0.0441 0.0938
Brugia malayi p70 ribosomal S6 kinase beta 0.0391 0.0148 0.0185
Brugia malayi intracellular kinase 0.1032 0.088 0.1132
Echinococcus multilocularis mitogen activated protein kinase 11 0.4334 0.465 0.4647
Entamoeba histolytica protein kinase , putative 0.0522 0.0298 0.309
Loa Loa (eye worm) hypothetical protein 0.028 0.0021 0.0021
Echinococcus multilocularis leucine rich repeat serine:threonine protein 0.0425 0.0186 0.0181
Loa Loa (eye worm) RhoGAP domain-containing protein 0.0295 0.0038 0.0043
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0345 0.0096 0.1034
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.0391 0.0148 0.0143
Echinococcus granulosus defective proboscis extension response 0.0584 0.0369 0.067
Schistosoma mansoni serine/threonine protein kinase 0.0331 0.008 0.0201
Trypanosoma cruzi casein kinase, putative 0.0506 0.0279 0.059
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.2159 0.2167 0.2163
Brugia malayi Variant SH3 domain containing protein 0.0335 0.0084 0.0103
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0334 0.0082 0.01
Echinococcus granulosus TGF beta receptor type 1 0.0842 0.0663 0.1212
Echinococcus multilocularis c src tyrosine kinase 0.0554 0.0334 0.0329
Entamoeba histolytica protein kinase domain containing protein 0.0355 0.0106 0.1101
Loa Loa (eye worm) CAMK/PIM protein kinase 0.1873 0.184 0.2373
Schistosoma mansoni nephrin 0.0787 0.06 0.1514
Brugia malayi EST embl|AI107989|AI107989 comes from the 3' UTR, putative 0.0843 0.0663 0.0852
Loa Loa (eye worm) hypothetical protein 0.0584 0.0369 0.047
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0453 0.0218 0.0393
Echinococcus granulosus epidermal growth factor receptor 0.0568 0.035 0.0636
Schistosoma mansoni serine/threonine protein kinase 0.1689 0.163 0.4111
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0345 0.0096 0.0195
Loa Loa (eye worm) AGC/PKA protein kinase 0.0648 0.0441 0.0564
Onchocerca volvulus 0.0365 0.0119 0.012
Onchocerca volvulus 0.0688 0.0487 0.0599
Echinococcus granulosus GTPase activating Rap:RanGAP domain 3 0.06 0.0386 0.0703
Loa Loa (eye worm) TK/ALK protein kinase 0.4961 0.5365 0.6933
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.0391 0.0148 0.0264
Brugia malayi cyclin-dependent kinase 7 homolog 0.063 0.0421 0.0538
Schistosoma mansoni tyrosine kinase 0.0401 0.0159 0.0401
Loa Loa (eye worm) CK1/CK1/CK1-A protein kinase 0.0506 0.0279 0.0354
Schistosoma mansoni growth factor receptor-bound protein 0.035 0.0101 0.0254
Trichomonas vaginalis STE family protein kinase 0.0286 0.0028 0.0208
Brugia malayi hypothetical protein 0.0401 0.0159 0.0199
Schistosoma mansoni serine/threonine protein kinase 0.0522 0.0298 0.0751
Echinococcus granulosus dual specificity testis-specific protein kinase 0.0349 0.01 0.0175
Entamoeba histolytica protein kinase, putative 0.1032 0.088 0.9146
Loa Loa (eye worm) CMGC/MAPK/JNK protein kinase 0.2652 0.273 0.3524
Loa Loa (eye worm) CK1/CK1/CK1-D protein kinase 0.0506 0.0279 0.0354
Onchocerca volvulus 0.0719 0.0523 0.0645
Echinococcus multilocularis activin receptor type 0.3981 0.4247 0.4244
Onchocerca volvulus 0.0401 0.0159 0.0172
Echinococcus multilocularis protein kinase shaggy 0.1032 0.088 0.0876
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.028 0.0021 0.0021
Echinococcus granulosus protein kinase 0.0786 0.0599 0.1094
Schistosoma mansoni tyrosine kinase 0.0995 0.0838 0.2113
Schistosoma mansoni serine/threonine protein kinase 0.091 0.074 0.1868
Echinococcus granulosus enhancer of mRNA decapping protein 4 0.0517 0.0292 0.0528
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0661 0.0457 0.0833
Plasmodium falciparum calcium-dependent protein kinase 1 0.0453 0.0218 0.2435
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.0584 0.0369 0.093
Loa Loa (eye worm) TKL/STKR/TYPE2 protein kinase 0.0737 0.0543 0.0696
Trichomonas vaginalis STE family protein kinase 0.1236 0.1112 1
Brugia malayi Protein kinase domain containing protein 0.0995 0.0838 0.1077
Echinococcus multilocularis Immunoglobulin 0.0584 0.0369 0.0364
Brugia malayi Dual specificity mitogen-activated protein kinase kinase mek-2 0.1236 0.1112 0.1432
Loa Loa (eye worm) CAMK/PKD protein kinase 0.085 0.0672 0.0863
Plasmodium falciparum calcium-dependent protein kinase 4 0.0453 0.0218 0.2435
Loa Loa (eye worm) TK/FER protein kinase 0.0401 0.0159 0.0199
Loa Loa (eye worm) CMGC/GSK protein kinase 0.1032 0.088 0.1132
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0789 0.0603 0.1102
Loa Loa (eye worm) hypothetical protein 0.0688 0.0487 0.0624
Trypanosoma cruzi mitogen-activated protein kinase kinase 5 0.1236 0.1112 0.2384
Onchocerca volvulus 0.0337 0.0086 0.0078
Brugia malayi Immunoglobulin I-set domain containing protein 0.0334 0.0082 0.01
Echinococcus granulosus protein kinase c epsilon type 0.0504 0.0277 0.0502
Schistosoma mansoni cell adhesion molecule 0.028 0.0021 0.0054
Echinococcus multilocularis protein kinase c epsilon type 0.0504 0.0277 0.0272
Schistosoma mansoni vam6/vps39 related 0.06 0.0386 0.0974
Echinococcus granulosus 5' AMP activated protein kinase catalytic 0.0843 0.0663 0.1214
Loa Loa (eye worm) TK/FER protein kinase 0.0401 0.0159 0.0199
Loa Loa (eye worm) TK protein kinase 0.0779 0.0591 0.0758
Trichomonas vaginalis AGC family protein kinase 0.0431 0.0193 0.17
Brugia malayi hypothetical protein 0.2574 0.264 0.3408
Trichomonas vaginalis STE family protein kinase 0.0286 0.0028 0.0208
Loa Loa (eye worm) hypothetical protein 0.0607 0.0394 0.0503
Onchocerca volvulus 0.7038 0.7737 1
Entamoeba histolytica PH domain containing protein kinase, putative 0.0686 0.0485 0.5032
Echinococcus multilocularis serine:threonine protein kinase 38 0.0391 0.0148 0.0143
Plasmodium falciparum calcium-dependent protein kinase 5 0.0453 0.0218 0.2435
Brugia malayi Protein kinase domain containing protein 0.7038 0.7737 1
Leishmania major protein kinase, putative 0.091 0.074 0.1583
Trichomonas vaginalis AGC family protein kinase 0.0391 0.0148 0.1295
Echinococcus granulosus MAM 0.0337 0.0086 0.0149
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.1024 0.087 0.0866
Giardia lamblia Kinase, CMGC CDK 0.0345 0.0096 0.0623
Trichomonas vaginalis AGC family protein kinase 0.0522 0.0298 0.2643
Brugia malayi Protein kinase domain containing protein 0.0345 0.0096 0.0117
Schistosoma mansoni serine/threonine protein kinase 0.0843 0.0663 0.1673
Loa Loa (eye worm) TK/FER protein kinase 0.0401 0.0159 0.0199
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.1032 0.088 1
Echinococcus multilocularis serine:threonine protein kinase receptor R3 0.0842 0.0663 0.0658
Schistosoma mansoni tyrosine kinase 0.047 0.0238 0.06
Echinococcus multilocularis neuropeptide receptor A26 0.0542 0.032 0.0315
Echinococcus multilocularis cyclin dependent kinase 0.0345 0.0096 0.0091
Loa Loa (eye worm) STE/STE20/MSN protein kinase 0.0786 0.0599 0.0768
Giardia lamblia Kinase, CAMK CAMKL 0.0305 0.005 0.0201
Brugia malayi Protein kinase domain containing protein 0.1104 0.0963 0.1238
Onchocerca volvulus 0.0606 0.0394 0.0477
Echinococcus multilocularis cyclin dependent kinase 5 0.0345 0.0096 0.0091
Brugia malayi hypothetical protein 0.0337 0.0086 0.0104
Echinococcus multilocularis mitogen activated protein kinase 14 0.4334 0.465 0.4647
Echinococcus multilocularis cyclin dependent kinase 9 0.0394 0.0151 0.0146
Echinococcus granulosus tyrosine protein kinase Lyn 0.1063 0.0915 0.1677
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.1143 0.1006 0.1846
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0453 0.0218 0.2435
Schistosoma mansoni serine/threonine protein kinase 0.0345 0.0096 0.0241
Echinococcus multilocularis growth factor receptor bound protein 2 0.0335 0.0084 0.008
Entamoeba histolytica protein kinase, putative 0.0391 0.0148 0.1538
Loa Loa (eye worm) hypothetical protein 0.0606 0.0394 0.0503
Echinococcus granulosus Protein kinase C brain isozyme 0.0504 0.0277 0.0502
Brugia malayi Immunoglobulin I-set domain containing protein 0.3118 0.3262 0.4212
Echinococcus granulosus dual specificity protein kinase clk2 0.091 0.074 0.1356
Onchocerca volvulus 0.0401 0.0159 0.0172
Schistosoma mansoni tyrosine kinase 0.0554 0.0334 0.0842
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.12 0.1072 0.1068
Trypanosoma brucei casein kinase I, isoform 2 0.0506 0.0279 0.059
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0648 0.0441 0.0803
Plasmodium vivax calcium-dependent protein kinase, putative 0.0453 0.0218 0.2027
Onchocerca volvulus Serine\/threonine protein kinase homolog 0.1873 0.184 0.2352
Schistosoma mansoni rap gtpase-activating protein 0.06 0.0386 0.0974
Echinococcus multilocularis neuroglian 0.0758 0.0567 0.0563
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0401 0.0159 0.0154
Schistosoma mansoni cell adhesion molecule 0.028 0.0021 0.0054
Brugia malayi Temporarily assigned gene name protein 59 0.06 0.0386 0.0493
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0779 0.0591 0.108
Giardia lamblia Kinase, CMGC CLK 0.091 0.074 0.6571
Loa Loa (eye worm) TK/FER protein kinase 0.0401 0.0159 0.0199
Onchocerca volvulus 0.0334 0.0082 0.0074
Brugia malayi Serine/threonine-protein kinase SULU 0.2574 0.264 0.3408
Loa Loa (eye worm) SRC-1 0.0932 0.0766 0.0984
Loa Loa (eye worm) hypothetical protein 0.0779 0.0591 0.0758
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.1391 0.129 0.1661
Loa Loa (eye worm) TK/ABL protein kinase 0.2245 0.2264 0.2922
Echinococcus multilocularis NCK adaptor protein 0.035 0.0101 0.0096
Echinococcus multilocularis serine:threonine protein kinase MARK2 0.0344 0.0094 0.0089
Echinococcus granulosus activated cdc42 kinase 1 0.1702 0.1645 0.3022
Giardia lamblia Kinase, CAMK CAMKL 0.0305 0.005 0.0201
Loa Loa (eye worm) TK protein kinase 0.1375 0.1271 0.1637
Echinococcus granulosus proto oncogene serine:threonine protein kinase 0.1873 0.184 0.3382
Trichomonas vaginalis CMGC family protein kinase 0.1032 0.088 0.7906
Echinococcus multilocularis serine:threonine protein kinase N2 0.1418 0.132 0.1316
Echinococcus multilocularis tyrosine protein kinase Srms 0.0779 0.0591 0.0586
Brugia malayi Protein kinase domain containing protein 0.0401 0.0159 0.0199
Plasmodium vivax serine/threonine kinase-1, putative 0.091 0.074 0.8316
Trichomonas vaginalis CMGC family protein kinase 0.0345 0.0096 0.0818
Echinococcus multilocularis dual specificity protein kinase clk2 0.091 0.074 0.0736
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.1143 0.1006 0.1295
Echinococcus granulosus dual specificity 0.1104 0.0963 0.1765
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0335 0.0084 0.0103
Brugia malayi serine/threonine protein kinase 6 0.0522 0.0298 0.0378
Echinococcus granulosus cyclin dependent kinase 0.0345 0.0096 0.0167
Trypanosoma brucei kinetoplastid kinetochore protein 10 0.091 0.074 0.1583
Loa Loa (eye worm) hypothetical protein 0.0587 0.0372 0.0474
Schistosoma mansoni growth factor receptor-bound protein 0.0335 0.0084 0.0213
Echinococcus multilocularis tyrosine protein kinase Blk 0.0779 0.0591 0.0586
Entamoeba histolytica protein kinase, putative 0.0391 0.0148 0.1538
Echinococcus multilocularis casein kinase I delta 0.0506 0.0279 0.0274
Loa Loa (eye worm) hypothetical protein 0.1255 0.1134 0.146
Schistosoma mansoni serine/threonine protein kinase 0.0453 0.0218 0.055
Echinococcus granulosus mitogen activated protein kinase 11 0.4334 0.465 0.8562
Schistosoma mansoni serine/threonine protein kinase 0.2652 0.273 0.6885
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0504 0.0277 0.0352
Loa Loa (eye worm) TK/EGFR protein kinase 0.0568 0.035 0.0446
Entamoeba histolytica protein kinase, putative 0.043 0.0192 0.1991
Brugia malayi Protein kinase domain 0.0286 0.0028 0.003
Loa Loa (eye worm) hypothetical protein 0.0801 0.0616 0.0791
Trichomonas vaginalis AGC family protein kinase 0.043 0.0192 0.1689
Schistosoma mansoni serine/threonine protein kinase 0.0648 0.0441 0.1112
Brugia malayi probable protein kinase 0.1386 0.1284 0.1654
Echinococcus granulosus neuropeptide receptor A26 0.0542 0.032 0.0581
Loa Loa (eye worm) hypothetical protein 0.0613 0.0401 0.0513
Entamoeba histolytica protein kinase domain containing protein 0.0349 0.01 0.1036
Echinococcus multilocularis contactin neuroglian septate junction protein 0.028 0.0021 0.0016
Trichomonas vaginalis AGC family protein kinase 0.043 0.0192 0.1689
Schistosoma mansoni protein kinase 0.0286 0.0028 0.0071
Entamoeba histolytica protein kinase, putative 0.0597 0.0383 0.3974
Trypanosoma cruzi cdc2-related kinase 1 0.0345 0.0096 0.0195
Echinococcus granulosus macrophage colony stimulating factor 1 receptor 0.5018 0.543 1
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0932 0.0766 0.0761
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0737 0.0543 0.0696
Toxoplasma gondii casein kinase I 0.0506 0.0279 0.3129
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 1 0.0648 0.0441 0.0938
Loa Loa (eye worm) TK/FER protein kinase 0.0401 0.0159 0.0199
Brugia malayi cell division control protein 2 homolog 0.0345 0.0096 0.0117
Schistosoma mansoni serine/threonine protein kinase 0.1104 0.0963 0.2428
Echinococcus multilocularis tyrosine protein kinase ABL1 0.2245 0.2264 0.226
Giardia lamblia Kinase, AGC PKA 0.0648 0.0441 0.3809
Loa Loa (eye worm) hypothetical protein 0.0571 0.0354 0.0451
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 1 0.0648 0.0441 0.0938
Echinococcus granulosus serine:threonine protein kinase mig 15 0.1255 0.1134 0.2081
Trichomonas vaginalis AGC family protein kinase 0.0522 0.0298 0.2643
Echinococcus multilocularis activated cdc42 kinase 1 0.1702 0.1645 0.164
Echinococcus granulosus cyclin dependent kinase 5 0.0345 0.0096 0.0167
Brugia malayi serine/threonine-protein kinase 6 0.0522 0.0298 0.0378
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0932 0.0766 0.1402
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0453 0.0218 0.0393
Schistosoma mansoni tyrosine kinase 0.035 0.0101 0.0255
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0932 0.0766 0.0761
Trichomonas vaginalis AGC family protein kinase 0.043 0.0192 0.1689
Schistosoma mansoni atypical protein kinase C 0.0504 0.0277 0.07
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0932 0.0766 0.0761
Trypanosoma cruzi cdc2-related kinase 3 0.0345 0.0096 0.0195
Entamoeba histolytica protein kinase, putative 0.0286 0.0028 0.0287
Trichomonas vaginalis STE family protein kinase 0.1236 0.1112 1
Schistosoma mansoni serine/threonine protein kinase 0.0266 0.0005 0.0013
Schistosoma mansoni protein kinase 0.0286 0.0028 0.0071
Loa Loa (eye worm) thyroid receptor interactor 0.0722 0.0525 0.0673
Echinococcus multilocularis p21 activated protein kinase 1 Dpak1 0.0286 0.0028 0.0023
Brugia malayi Protein kinase domain containing protein 0.1689 0.163 0.2102
Echinococcus multilocularis dual specificity mitogen activated protein 0.1236 0.1112 0.1108
Schistosoma mansoni protein kinase 0.0286 0.0028 0.0071
Schistosoma mansoni mitogen-activated protein kinase kinase kinase 3 mapkkk3 mekk3 0.06 0.0386 0.0974
Echinococcus multilocularis mitogen activated protein kinase 11 0.4334 0.465 0.4647
Loa Loa (eye worm) TK/INSR protein kinase 0.0995 0.0838 0.1077
Echinococcus granulosus serine:threonine protein kinase PAK 3 0.0286 0.0028 0.0042
Onchocerca volvulus 0.0401 0.0159 0.0172
Echinococcus multilocularis epidermal growth factor receptor 0.0568 0.035 0.0345
Trypanosoma cruzi aurora B kinase, putative 0.0522 0.0298 0.063
Plasmodium vivax serine/threonine protein kinase 6, putative 0.0522 0.0298 0.2984
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0453 0.0218 0.2435
Echinococcus multilocularis casein kinase I alpha 0.0506 0.0279 0.0274
Echinococcus granulosus serine:threonine protein kinase MARK2 0.0344 0.0094 0.0164
Echinococcus granulosus glycogen synthase kinase 3 beta 0.1032 0.088 0.1613
Trypanosoma brucei Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative 0.06 0.0386 0.0821
Schistosoma mansoni protein kinase 0.0786 0.0599 0.151
Echinococcus multilocularis neuropeptide s receptor 0.0542 0.032 0.0315
Leishmania major protein kinase A catalytic subunit 0.0648 0.0441 0.0938
Echinococcus granulosus c src tyrosine kinase 0.0554 0.0334 0.0606
Loa Loa (eye worm) CMGC/CDK/CDK7 protein kinase 0.0591 0.0376 0.048
Loa Loa (eye worm) STE/STE20/KHS protein kinase 0.2159 0.2167 0.2796
Loa Loa (eye worm) TK/ROR protein kinase 0.0392 0.015 0.0187
Echinococcus multilocularis protein tyrosine kinase 0.3734 0.3965 0.3962
Schistosoma mansoni vav2 0.0333 0.0082 0.0207
Entamoeba histolytica serine/threonine protein kinase 6, putative 0.0522 0.0298 0.309
Schistosoma mansoni Neurotrimin precursor (hNT) 0.0584 0.0369 0.093
Entamoeba histolytica protein kinase, putative 0.0522 0.0298 0.309
Leishmania major rac serine-threonine kinase, putative,protein kinase, putative 0.092 0.0752 0.1609
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.0295 0.0038 0.0033
Brugia malayi Protein kinase domain containing protein 0.0401 0.0159 0.0199
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase subunit type II alpha 0.1542 0.1462 0.1885
Entamoeba histolytica protein kinase domain containing protein 0.1032 0.088 0.9146
Schistosoma mansoni serine/threonine kinase 0.0391 0.0148 0.0374
Loa Loa (eye worm) hypothetical protein 0.0571 0.0354 0.0451
Echinococcus granulosus cyclin dependent kinase 1 0.0345 0.0096 0.0167
Entamoeba histolytica p21-activated kinase 0.0324 0.0072 0.074
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.091 0.074 0.1583
Trichomonas vaginalis CK1 family protein kinase 0.0506 0.0279 0.2474
Echinococcus multilocularis serine:threonine protein kinase MARK2 0.0344 0.0094 0.0089
Echinococcus granulosus protein tyrosine kinase 0.3734 0.3965 0.7298
Trichomonas vaginalis CMGC family protein kinase 0.091 0.074 0.6643
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.12 0.1072 0.1967
Leishmania major mitogen-activated protein kinase 3, putative,map kinase 3, putative 0.4334 0.465 1
Echinococcus granulosus neuroglian 0.028 0.0021 0.003
Giardia lamblia Kinase, CK1 Casein kinase 0.0506 0.0279 0.2314
Loa Loa (eye worm) hypothetical protein 0.0648 0.0441 0.0564
Echinococcus granulosus activin receptor type 0.3981 0.4247 0.7818
Trypanosoma brucei mitogen-activated protein kinase kinase 5 0.1236 0.1112 0.2384
Echinococcus granulosus tyrosine protein kinase Src42A 0.0932 0.0766 0.1402
Schistosoma mansoni serine/threonine protein kinase 0.2574 0.264 0.666
Trypanosoma brucei cdc2-related kinase 1 0.0345 0.0096 0.0195
Echinococcus granulosus neuroglian 0.0758 0.0567 0.1037
Schistosoma mansoni serine/threonine protein kinase 0.0424 0.0185 0.0467
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0401 0.0159 0.0283
Brugia malayi Protein kinase domain containing protein 0.4962 0.5367 0.6935
Schistosoma mansoni hypothetical protein 0.0337 0.0086 0.0216
Trichomonas vaginalis AGC family protein kinase 0.0648 0.0441 0.3937
Echinococcus multilocularis titin 0.0334 0.0082 0.0077
Entamoeba histolytica protein kinase, putative 0.0522 0.0298 0.309
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.1104 0.0963 0.1238
Schistosoma mansoni tyrosine kinase 0.0789 0.0603 0.1521
Toxoplasma gondii protein kinase, cAMP-dependent, catalytic chain 0.0648 0.0441 0.498
Trypanosoma cruzi cdc2-related kinase 3 0.0345 0.0096 0.0195
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0453 0.0218 0.2435
Schistosoma mansoni serine/threonine protein kinase 0.0648 0.0441 0.1112
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0345 0.0096 0.0117
Schistosoma mansoni serine/threonine protein kinase 0.1531 0.1449 0.3656
Echinococcus granulosus tyrosine protein kinase Fyn 0.0932 0.0766 0.1402
Echinococcus granulosus casein kinase I alpha 0.0506 0.0279 0.0505
Brugia malayi Serine/threonine-protein kinase Pim-3 0.1873 0.184 0.2373
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0648 0.0441 0.0436
Echinococcus granulosus casein kinase I delta 0.0506 0.0279 0.0505
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.028 0.0021 0.0016
Brugia malayi protein-tyrosine kinase 0.0779 0.0591 0.0758
Echinococcus multilocularis tyrosine protein kinase shark 0.0401 0.0159 0.0154
Loa Loa (eye worm) STE/STE20/TAO protein kinase 0.2574 0.264 0.3408
Trichomonas vaginalis AGC family protein kinase 0.043 0.0192 0.1689
Loa Loa (eye worm) CMGC/GSK protein kinase 0.1032 0.088 0.1132
Echinococcus granulosus protein kinase shaggy 0.1032 0.088 0.1613
Schistosoma mansoni protein kinase 0.0522 0.0298 0.0751
Schistosoma mansoni serine/threonine protein kinase 0.0266 0.0005 0.0013
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.1531 0.1449 0.1868
Echinococcus multilocularis protein KINase family member (kin 25) 0.0789 0.0603 0.0598
Entamoeba histolytica serine/threonine protein kinase, putative 0.0266 0.0005 0.0048
Leishmania major casein kinase, putative 0.0506 0.0279 0.059
Schistosoma mansoni serine/threonine protein kinase 0.0271 0.0011 0.0027
Echinococcus granulosus growth factor receptor bound protein 2 0.035 0.0101 0.0176
Trichomonas vaginalis CMGC family protein kinase 0.0345 0.0096 0.0818
Echinococcus multilocularis 5' AMP activated protein kinase catalytic 0.0843 0.0663 0.0659
Echinococcus multilocularis serine:threonine protein kinase 12 B 0.0522 0.0298 0.0293
Schistosoma mansoni tyrosine kinase 0.0568 0.035 0.0883
Echinococcus granulosus c-Jun N-terminal kinases 0.2652 0.273 0.5022
Loa Loa (eye worm) TK/KIN16 protein kinase 0.3118 0.3262 0.4212
Schistosoma mansoni tyrosine kinase 0.12 0.1072 0.2704
Schistosoma mansoni serine/threonine protein kinase 0.0334 0.0082 0.0208
Trypanosoma cruzi casein kinase, putative 0.0506 0.0279 0.059
Brugia malayi bone morphogenetic protein type 1 receptor 0.0929 0.0763 0.098
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0335 0.0084 0.0103
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0554 0.0334 0.0842
Entamoeba histolytica protein kinase domain containing protein 0.1032 0.088 0.9146
Brugia malayi Tyrosine-protein kinase abl-1 0.1139 0.1002 0.1289
Schistosoma mansoni serine/threonine protein kinase 0.0271 0.0011 0.0027
Loa Loa (eye worm) TKL/STKR/TYPE1 protein kinase 0.0929 0.0763 0.098
Brugia malayi cyclin-dependent kinase 9 0.0355 0.0106 0.0131
Echinococcus granulosus protein kinase c iota type 0.0504 0.0277 0.0502
Plasmodium falciparum casein kinase 1 0.0506 0.0279 0.3129
Echinococcus granulosus cyclin dependent kinase 7 0.0591 0.0376 0.0684
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0453 0.0218 0.0213
Loa Loa (eye worm) hypothetical protein 0.0836 0.0656 0.0841
Schistosoma mansoni mitogen-activated protein kinase kinase kinase 3 mapkkk3 mekk3 0.06 0.0386 0.0974
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0584 0.0369 0.0364
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0932 0.0766 0.1402
Schistosoma mansoni tyrosine kinase 0.2136 0.214 0.5398
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.091 0.074 0.1583
Schistosoma mansoni protein kinase 0.0349 0.01 0.0252
Schistosoma mansoni protein kinase 0.1236 0.1112 0.2805
Brugia malayi Variant SH3 domain containing protein 0.0335 0.0084 0.0103
Schistosoma mansoni tyrosine kinase 0.0374 0.0128 0.0323
Echinococcus multilocularis N chimaerin 0.0295 0.0038 0.0033
Trypanosoma cruzi casein kinase, putative 0.0506 0.0279 0.059
Plasmodium falciparum protein kinase, putative 0.0349 0.01 0.1086
Trypanosoma brucei aurora B kinase 0.0522 0.0298 0.063
Schistosoma mansoni protein kinase 0.1995 0.1979 0.4992
Schistosoma mansoni serine/threonine protein kinase 0.0266 0.0005 0.0013
Toxoplasma gondii AGC kinase 0.0648 0.0441 0.498
Brugia malayi RhoGAP domain containing protein 0.0295 0.0038 0.0043
Echinococcus granulosus serine:threonine protein kinase PAK 4 0.1791 0.1746 0.3209
Schistosoma mansoni adapter molecule crk 0.0335 0.0084 0.0213
Brugia malayi Stress-activated protein kinase jnk-1 0.2652 0.273 0.3524
Loa Loa (eye worm) hypothetical protein 0.1483 0.1395 0.1798
Loa Loa (eye worm) AUR protein kinase 0.0522 0.0298 0.0378
Echinococcus granulosus NDR protein kinase 0.0391 0.0148 0.0264
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0295 0.0038 0.0097
Loa Loa (eye worm) AGC/AKT protein kinase 0.043 0.0192 0.0242
Brugia malayi Immunoglobulin I-set domain containing protein 0.0433 0.0196 0.0247
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0349 0.01 0.0205
Echinococcus multilocularis insulin receptor 0.0995 0.0838 0.0833
Trypanosoma brucei protein kinase, putative 0.1032 0.088 0.1884
Brugia malayi serine/threonine-protein kinase PAK 7 0.1946 0.1923 0.2481
Schistosoma mansoni neuroglian 0.028 0.0021 0.0054
Brugia malayi Protein kinase domain containing protein 0.3776 0.4012 0.5183
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0433 0.0196 0.0247
Schistosoma mansoni protein kinase 0.0842 0.0663 0.1672
Onchocerca volvulus 0.0375 0.013 0.0135
Entamoeba histolytica protein kinase, putative 0.0286 0.0028 0.0287
Brugia malayi C1-like domain containing protein 0.085 0.0672 0.0863
Echinococcus granulosus Immunoglobulin 0.0584 0.0369 0.067
Trichomonas vaginalis AGC family protein kinase 0.043 0.0192 0.1689
Schistosoma mansoni serine/threonine protein kinase 0.0843 0.0665 0.1676
Echinococcus granulosus rho-associated protein kinase 1 0.0424 0.0185 0.0332
Echinococcus multilocularis mitogen activated protein kinase 14 0.4334 0.465 0.4647
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0453 0.0218 0.0213
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.1995 0.1979 0.3639
Loa Loa (eye worm) TK/FER protein kinase 0.0401 0.0159 0.0199
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0731 0.0536 0.0978
Echinococcus multilocularis dual specificity 0.1104 0.0963 0.0958
Loa Loa (eye worm) G protein-coupled receptor kinase 1 0.1391 0.129 0.1661
Leishmania major protein kinase A catalytic subunit isoform 1 0.0648 0.0441 0.0938
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.1032 0.088 0.1884
Echinococcus multilocularis cyclin dependent kinase 1 0.0345 0.0096 0.0091
Echinococcus granulosus leucine rich repeat serine:threonine protein 0.0424 0.0186 0.0333
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0401 0.0159 0.1646
Schistosoma mansoni serine/threonine protein kinase 0.0305 0.005 0.0125
Echinococcus multilocularis transfer RNA-Thr 0.1702 0.1645 0.164
Echinococcus granulosus beta-adrenergic receptor kinase 0.0271 0.0011 0.001
Echinococcus granulosus cyclin dependent kinase 19 0.1689 0.163 0.2995
Echinococcus multilocularis roundabout 2 0.0864 0.0688 0.0684
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0932 0.0766 0.0761
Brugia malayi Immunoglobulin I-set domain containing protein 0.028 0.0021 0.0021
Entamoeba histolytica serine/threonine- protein kinase 6, putative 0.0522 0.0298 0.309
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.4334 0.465 1
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.091 0.074 0.1583
Toxoplasma gondii AGC kinase 0.0648 0.0441 0.498
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0345 0.0096 0.0195
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.1104 0.0963 0.2061
Echinococcus granulosus N chimaerin 0.0295 0.0038 0.0062
Brugia malayi Tyrosine-protein kinase abl-1 0.1259 0.1139 0.1466
Brugia malayi casein kinase I 0.0506 0.0279 0.0354
Trypanosoma cruzi casein kinase, putative 0.0506 0.0279 0.059
Loa Loa (eye worm) CK1/CK1/CK1-A protein kinase 0.0506 0.0279 0.0354
Brugia malayi SH2 domain containing protein 0.0401 0.0159 0.0199
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0648 0.0441 0.0436
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.1995 0.1979 0.1975
Echinococcus granulosus [G-protein-coupledreceptor] kinase 0.1391 0.129 0.2368
Trypanosoma cruzi Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative 0.06 0.0386 0.0821
Loa Loa (eye worm) TK/FER protein kinase 0.0401 0.0159 0.0199
Loa Loa (eye worm) TK/FER protein kinase 0.0401 0.0159 0.0199
Trypanosoma brucei kinetoplastid kinetochore protein 19 0.091 0.074 0.1583
Plasmodium vivax protein kinase Crk2 0.0345 0.0096 0.0551
Schistosoma mansoni serine/threonine protein kinase 0.156 0.1482 0.3738
Loa Loa (eye worm) CMGC/CLK protein kinase 0.091 0.074 0.0951
Trypanosoma brucei mitogen-activated protein kinase 3, putative 0.4334 0.465 1
Trypanosoma cruzi cdc2-related kinase 1 0.0345 0.0096 0.0195
Echinococcus granulosus serine:threonine protein kinase N2 0.1418 0.132 0.2424
Schistosoma mansoni protein kinase 0.2159 0.2167 0.5466
Echinococcus multilocularis serine:threonine protein kinase PAK 3 0.0286 0.0028 0.0023
Trichomonas vaginalis AGC family protein kinase 0.043 0.0192 0.1689
Loa Loa (eye worm) hypothetical protein 0.1702 0.1645 0.212
Trypanosoma cruzi casein kinase, delta isoform, putative 0.0375 0.013 0.0268
Echinococcus granulosus serine:threonine protein kinase PAK 3 0.0286 0.0028 0.0042
Entamoeba histolytica hypothetical protein 0.1104 0.0963 1
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0453 0.0218 0.0459
Entamoeba histolytica protein kinase, putative 0.0324 0.0072 0.074
Plasmodium vivax casein kinase 1, putative 0.0506 0.0279 0.2759
Brugia malayi protein unc-22 0.0334 0.0082 0.01
Schistosoma mansoni tyrosine kinase 0.0568 0.035 0.0883
Echinococcus multilocularis MAM 0.0337 0.0086 0.0081
Schistosoma mansoni serine/threonine protein kinase 0.0344 0.0094 0.0237
Schistosoma mansoni serine/threonine protein kinase 0.0843 0.0665 0.1676
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.028 0.0021 0.0054
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0648 0.0441 0.0436
Echinococcus multilocularis dual specificity testis specific protein kinase 0.0349 0.01 0.0095
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.0648 0.0441 0.0938
Echinococcus multilocularis serine:threonine protein kinase PAK 4 0.1791 0.1746 0.1742
Leishmania major protein kinase, putative 0.091 0.074 0.1583
Brugia malayi Protein kinase domain containing protein 0.091 0.074 0.0951
Echinococcus granulosus tyrosine protein kinase Src42A 0.0575 0.0358 0.065
Loa Loa (eye worm) CAMK/PIM protein kinase 0.1873 0.184 0.2373
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.1143 0.1006 0.1002
Entamoeba histolytica protein kinase, putative 0.0453 0.0218 0.2264
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.4334 0.465 1
Schistosoma mansoni nephrin 0.028 0.0021 0.0054
Onchocerca volvulus 0.1032 0.088 0.1108
Trichomonas vaginalis CAMK family protein kinase 0.0453 0.0218 0.1925
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0271 0.0011 0.0007
Brugia malayi Immunoglobulin I-set domain containing protein 0.1375 0.1271 0.1637
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.091 0.074 0.1583
Leishmania major protein kinase, putative 0.0453 0.0218 0.0459
Echinococcus multilocularis serine:threonine protein kinase N2 0.1026 0.0874 0.0869
Echinococcus granulosus tyrosine protein kinase Blk 0.0779 0.0591 0.108
Loa Loa (eye worm) AGC/PKN protein kinase 0.1418 0.132 0.1701
Loa Loa (eye worm) STE/STE20/PAKB protein kinase 0.1946 0.1923 0.2481
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.2159 0.2167 0.3985
Toxoplasma gondii aurora kinase 0.0522 0.0298 0.3343
Loa Loa (eye worm) gastrulation defective protein 1 0.1558 0.1481 0.1909
Entamoeba histolytica protein kinase domain containing protein 0.0522 0.0298 0.309
Echinococcus multilocularis enhancer of mRNA decapping protein 4 0.0517 0.0292 0.0287
Loa Loa (eye worm) CMGC/MAPK/P38 protein kinase 0.4334 0.465 0.6007
Plasmodium falciparum calcium-dependent protein kinase 3 0.0453 0.0218 0.2435
Loa Loa (eye worm) hypothetical protein 0.0688 0.0487 0.0624
Echinococcus granulosus serine:threonine protein kinase TAO1 0.2574 0.264 0.4857
Brugia malayi Furin-like cysteine rich region family protein 0.0568 0.035 0.0446
Schistosoma mansoni serine/threonine protein kinase 0.0355 0.0106 0.0268
Toxoplasma gondii calcium dependent protein kinase CDPK8 0.0349 0.01 0.1086
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.1542 0.1462 0.1885
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0391 0.0148 0.0185
Schistosoma mansoni serine/threonine protein kinase 0.0391 0.0148 0.0374
Brugia malayi Protein kinase domain containing protein 0.1702 0.1645 0.212
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0345 0.0096 0.0167
Loa Loa (eye worm) hypothetical protein 0.0974 0.0813 0.1045
Trypanosoma cruzi casein kinase, delta isoform, putative 0.0506 0.0279 0.059
Schistosoma mansoni serine/threonine protein kinase 0.0504 0.0277 0.07
Echinococcus granulosus roundabout 2 0.028 0.0021 0.003
Echinococcus multilocularis epidermal growth factor receptor 0.0568 0.035 0.0345
Giardia lamblia Kinase, CMGC GSK 0.1032 0.088 0.7862
Loa Loa (eye worm) TKL/STKR/TYPE1 protein kinase 0.0737 0.0543 0.0696
Brugia malayi Fes/CIP4 homology domain containing protein 0.0722 0.0525 0.0673
Brugia malayi Protein kinase domain containing protein 0.0401 0.0159 0.0199
Loa Loa (eye worm) AUR protein kinase 0.0522 0.0298 0.0378
Trichomonas vaginalis STE family protein kinase 0.0286 0.0028 0.0208
Entamoeba histolytica protein kinase, putative 0.1104 0.0963 1
Loa Loa (eye worm) AGC/DMPK/ROCK protein kinase 0.1042 0.0891 0.1146
Brugia malayi Cam kinase protein 1 0.0453 0.0218 0.0276
Onchocerca volvulus 0.0506 0.0279 0.0328
Entamoeba histolytica cell division protein kinase 2, putative 0.0384 0.014 0.1455
Echinococcus granulosus tyrosine protein kinase Fyn 0.0932 0.0766 0.1402
Brugia malayi Protein kinase domain containing protein 0.1042 0.0891 0.1146
Loa Loa (eye worm) AUR protein kinase 0.0522 0.0298 0.0378
Echinococcus granulosus casein kinase I delta 0.0506 0.0279 0.0505
Loa Loa (eye worm) hypothetical protein 0.0923 0.0756 0.0971
Plasmodium vivax cAMP-dependent protein kinase catalytic subunit, putative 0.0648 0.0441 0.4709
Echinococcus granulosus epidermal growth factor receptor 0.0568 0.035 0.0636
Brugia malayi serine/threonine kinase 12 0.0522 0.0298 0.0378
Schistosoma mansoni protein kinase 0.1995 0.1979 0.4992
Brugia malayi Protein kinase domain containing protein 0.043 0.0192 0.0242
Echinococcus multilocularis rho associated protein kinase 0.0424 0.0185 0.018
Echinococcus multilocularis cyclin dependent kinase 19 0.1689 0.163 0.1626
Schistosoma mansoni serine/threonine protein kinase 0.091 0.074 0.1868
Echinococcus multilocularis roundabout 2 0.028 0.0021 0.0016
Echinococcus multilocularis tyrosine protein kinase HCK 0.0597 0.0383 0.0378
Entamoeba histolytica serine/threonine- protein kinase 6 , putative 0.0522 0.0298 0.309
Loa Loa (eye worm) hypothetical protein 0.0401 0.0159 0.0199
Loa Loa (eye worm) hypothetical protein 0.0688 0.0487 0.0624
Echinococcus granulosus fibroblast growth factor receptor 4 0.12 0.1072 0.1967
Schistosoma mansoni protein kinase C mu 0.085 0.0672 0.1695
Loa Loa (eye worm) CMGC/CDK/CDK8 protein kinase 0.1689 0.163 0.2102
Schistosoma mansoni protein kinase 0.1386 0.1284 0.3238
Echinococcus granulosus Vam6:Vps39 protein 0.06 0.0386 0.0703
Echinococcus multilocularis serine:threonine protein kinase MRCK beta 0.0843 0.0665 0.066
Echinococcus multilocularis TGF beta receptor type 1 0.0842 0.0663 0.0658
Trichomonas vaginalis AGC family protein kinase 0.043 0.0192 0.1689
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0345 0.0096 0.0117
Loa Loa (eye worm) hypothetical protein 0.0974 0.0813 0.1045
Echinococcus multilocularis c Jun NH2 terminal kinase 0.2652 0.273 0.2726
Trypanosoma brucei protein kinase A catalytic subunit, putative 0.0648 0.0441 0.0938
Trypanosoma cruzi casein kinase, putative 0.0506 0.0279 0.059
Echinococcus granulosus tyrosine protein kinase Src64B 0.0932 0.0766 0.1402
Brugia malayi Hr1 repeat family protein 0.1418 0.132 0.1701
Trichomonas vaginalis STE family protein kinase 0.0286 0.0028 0.0208
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.0391 0.0148 0.0185
Schistosoma mansoni tyrosine kinase 0.2062 0.2056 0.5186
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0411 0.0171 0.0214
Echinococcus multilocularis serine:threonine protein kinase TAO1 0.2574 0.264 0.2637
Echinococcus multilocularis twitchin 0.0305 0.005 0.0045
Loa Loa (eye worm) hypothetical protein 0.0335 0.0084 0.0103
Echinococcus granulosus activated cdc42 kinase 1 0.1702 0.1645 0.3022
Loa Loa (eye worm) hypothetical protein 0.0337 0.0086 0.0104
Toxoplasma gondii cell-cycle-associated protein kinase CLK, putative 0.091 0.074 0.8402
Onchocerca volvulus 0.0758 0.0566 0.0701
Plasmodium falciparum glycogen synthase kinase 3 0.1032 0.088 1
Echinococcus granulosus titin 0.0334 0.0082 0.0143
Brugia malayi hypothetical protein 0.0607 0.0394 0.0503
Loa Loa (eye worm) hypothetical protein 0.0453 0.0218 0.0276
Echinococcus granulosus tyrosine protein kinase HCK 0.0597 0.0383 0.0696
Trichomonas vaginalis AGC family protein kinase 0.0391 0.0148 0.1295
Echinococcus granulosus casein kinase I alpha 0.0506 0.0279 0.0505
Entamoeba histolytica protein kinase, putative 0.043 0.0192 0.1991
Schistosoma mansoni cell adhesion molecule 0.069 0.049 0.1235
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0453 0.0218 0.0276
Schistosoma mansoni tyrosine kinase 0.0932 0.0766 0.1931
Echinococcus granulosus tyrosine protein kinase Btk29A 0.2275 0.2299 0.4228
Echinococcus granulosus dual specificity mitogen activated protein 0.1236 0.1112 0.2041
Echinococcus granulosus calcium dependent protein kinase 0.0322 0.0069 0.0118
Brugia malayi SRC-1 0.0932 0.0766 0.0984
Schistosoma mansoni tyrosine kinase 0.0554 0.0334 0.0842
Echinococcus multilocularis proto oncogene serine:threonine protein kinase 0.1873 0.184 0.1836
Schistosoma mansoni serine/threonine protein kinase 0.0506 0.0279 0.0704
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0453 0.0218 0.0393
Schistosoma mansoni protein kinase 0.1995 0.1979 0.4992
Loa Loa (eye worm) hypothetical protein 0.0337 0.0086 0.0104
Echinococcus granulosus cyclin dependent kinase 9 0.0394 0.0151 0.0269

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 0.11 ug/ml DNDI: Inhibition of Human African Trypanosomiasis, SBRI 427, in vitro ChEMBL. No reference
IC50 (functional) = 0.31 ug/ml DNDI: Inhibition of Human African Trypanosomiasis, SBRI 427, in vitro ChEMBL. No reference
IC50 (functional) = 0.357 ug/ml DNDI DNDI. No reference
IC50 (functional) = 0.497 ug/ml DNDI: Inhibition of the malaria parasite Plasmodium falciparum, in vitro ChEMBL. No reference
IC50 (functional) = 0.57 ug/ml DNDI: Inhibition of Human African Trypanosomiasis, Cross 22, in vitro ChEMBL. No reference
IC50 (functional) = 0.58 ug/ml DNDI: Inhibition of Human African Trypanosomiasis, SBRI 427, in vitro ChEMBL. No reference
IC50 = 0.79 ug/ml DNDI: Cytotoxicity against L929 mouse fibroblasts, 72 hour. ChEMBL. No reference
IC50 (functional) = 1.4 ug/ml DNDI: Inhibition of Chagas Disease parasite Trypanosoma cruzi (Tulahuen LacZ, Clone C4), in vitro. ChEMBL. No reference
IC50 (functional) = 4.61 ug/ml DNDI: Inhibition of formation of Leishmania donovani (strain MHOM/ET/67/L82) axenic amastigotes, in vitro. ChEMBL. No reference
IC50 > 50 ug/ml DNDI: Cytotoxicity against L929 mouse fibroblasts, CYTO-SP, 24 hour ChEMBL. No reference
MSD (functional) = 3.5 day DNDI: Mean survival time in days (MSD) of mice after intraperitoneal injection of Human African Trypanosomiasis (HAT), EATRO 110, in vivo at 20 mg/kg/day for 4 days. ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Trypanosoma brucei gambiense
Plasmodium falciparum ChEMBL23
Leishmania donovani ChEMBL23
Trypanosoma cruzi ChEMBL23
Trypanosoma brucei ChEMBL23
Mus musculus ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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