Detailed information for compound 1079558

Basic information

Technical information
  • TDR Targets ID: 1079558
  • Name: NSC711784
  • MW: 306.315 | Formula: C18H14N2O3
  • H donors: 2 H acceptors: 2 LogP: 2.41 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: COC(=O)c1ccc2c(c1)c1CC(=O)Nc3c(c1[nH]2)cccc3
  • InChi: 1S/C18H14N2O3/c1-23-18(22)10-6-7-15-12(8-10)13-9-16(21)19-14-5-3-2-4-11(14)17(13)20-15/h2-8,20H,9H2,1H3,(H,19,21)
  • InChiKey: YKROMFXYBBYDLR-UHFFFAOYSA-N  


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Synonyms

  • NCI60_039203

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens cyclin B2 Starlite/ChEMBL References
Homo sapiens cyclin B3 Starlite/ChEMBL References
Homo sapiens cyclin-dependent kinase 3 References
Homo sapiens malate dehydrogenase 2, NAD (mitochondrial) Starlite/ChEMBL References
Homo sapiens glycogen synthase kinase 3 beta Starlite/ChEMBL References
Homo sapiens cyclin B1 References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Cryptosporidium hominis mitotic cyclin-CYC2 Get druggable targets OG5_126649 All targets in OG5_126649
Plasmodium vivax protein kinase Crk2 Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania braziliensis mitochondrial malate dehydrogenase Get druggable targets OG5_127145 All targets in OG5_127145
Cryptosporidium parvum Cdc2-like CDK2/CDC28 like protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma cruzi glycogen synthase kinase 3, putative Get druggable targets OG5_126888 All targets in OG5_126888
Plasmodium falciparum glycogen synthase kinase 3 Get druggable targets OG5_126888 All targets in OG5_126888
Plasmodium vivax glycogen synthase kinase 3, putative Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania mexicana malate dehydrogenase, putative Get druggable targets OG5_127145 All targets in OG5_127145
Echinococcus granulosus cyclin dependent kinase Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania infantum CYC2-like cyclin, putative,cyclin 6, putative Get druggable targets OG5_126649 All targets in OG5_126649
Trichomonas vaginalis cyclin B, putative Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania mexicana cell division protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania donovani mitochondrial malate dehydrogenase Get druggable targets OG5_127145 All targets in OG5_127145
Leishmania mexicana cell division related protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus multilocularis cyclin dependent kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania braziliensis glycosomal malate dehydrogenase Get druggable targets OG5_127145 All targets in OG5_127145
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania donovani glycosomal malate dehydrogenase Get druggable targets OG5_127145 All targets in OG5_127145
Schistosoma japonicum IPR002155,Thiolase,domain-containing Get druggable targets OG5_134175 All targets in OG5_134175
Leishmania major mitochondrial malate dehydrogenase Get druggable targets OG5_127145 All targets in OG5_127145
Echinococcus granulosus cyclin dependent kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma cruzi mitochondrial malate dehydrogenase, putative Get druggable targets OG5_127145 All targets in OG5_127145
Echinococcus granulosus protein kinase shaggy Get druggable targets OG5_126888 All targets in OG5_126888
Entamoeba histolytica protein kinase domain containing protein Get druggable targets OG5_126888 All targets in OG5_126888
Plasmodium falciparum protein kinase 5 Get druggable targets OG5_126712 All targets in OG5_126712
Candida albicans similar to S. cerevisiae MDH1 (YKL085W) mitochondrial malate dehydrogenase Get druggable targets OG5_127145 All targets in OG5_127145
Entamoeba histolytica cyclin, putative Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 Get druggable targets OG5_126888 All targets in OG5_126888
Trypanosoma brucei gambiense cell division protein kinase 2 homolog 1,cdc2- like protein kinase, putative Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma cruzi cyclin, putative Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma brucei cdc2-related kinase 3 Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma brucei glycosomal malate dehydrogenase Get druggable targets OG5_127145 All targets in OG5_127145
Loa Loa (eye worm) cyclin domain-containing protein Get druggable targets OG5_134175 All targets in OG5_134175
Echinococcus granulosus cyclin B Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania braziliensis cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania donovani CYC2-like cyclin, putative Get druggable targets OG5_126649 All targets in OG5_126649
Entamoeba histolytica cell division protein kinase 2, putative Get druggable targets OG5_126712 All targets in OG5_126712
Candida albicans Protein kinase that can substitute for S. cerevisiae CDC28 (YBR160W) main cell cycle cyclin-dependent kinase Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania major glycosomal malate dehydrogenase Get druggable targets OG5_127145 All targets in OG5_127145
Echinococcus granulosus G2:mitotic specific cyclin B3 Get druggable targets OG5_134175 All targets in OG5_134175
Trypanosoma cruzi cyclin, putative Get druggable targets OG5_126649 All targets in OG5_126649
Schistosoma japonicum ko:K05868 cyclin B, putative Get druggable targets OG5_126649 All targets in OG5_126649
Plasmodium yoelii cdc2-related kinase 2 Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma congolense cdc2-related kinase 1, putative Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus multilocularis malate dehydrogenase Get druggable targets OG5_127145 All targets in OG5_127145
Neospora caninum hypothetical protein Get druggable targets OG5_126888 All targets in OG5_126888
Giardia lamblia Kinase, CMGC GSK Get druggable targets OG5_126888 All targets in OG5_126888
Plasmodium knowlesi glycogen synthase kinase 3, putative Get druggable targets OG5_126888 All targets in OG5_126888
Trypanosoma congolense protein kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Trypanosoma cruzi glycosomal malate dehydrogenase, putative Get druggable targets OG5_127145 All targets in OG5_127145
Candida albicans similar to S. cerevisiae MDH3 (YDL078C) peroxisomal malate dehydrogenase Get druggable targets OG5_127145 All targets in OG5_127145
Candida albicans Protein kinase that can substitute for S. cerevisiae CDC28 (YBR160W) main cell cycle cyclin-dependent kinase Get druggable targets OG5_126712 All targets in OG5_126712
Babesia bovis protein kinase domain containing protein Get druggable targets OG5_126888 All targets in OG5_126888
Babesia bovis cell division control protein 2, putative Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania infantum glycosomal malate dehydrogenase Get druggable targets OG5_127145 All targets in OG5_127145
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania donovani cell division protein kinase 2 Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma mansoni cyclin B3 Get druggable targets OG5_134175 All targets in OG5_134175
Brugia malayi Probable malate dehydrogenase, mitochondrial precursor Get druggable targets OG5_127145 All targets in OG5_127145
Brugia malayi Cyclin, N-terminal domain containing protein Get druggable targets OG5_126649 All targets in OG5_126649
Schistosoma mansoni cyclin B Get druggable targets OG5_126649 All targets in OG5_126649
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126712 All targets in OG5_126712
Candida albicans second truncated form of RIM11 Serine/threonine protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Trichomonas vaginalis cyclin A, putative Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma brucei mitochondrial malate dehydrogenase Get druggable targets OG5_127145 All targets in OG5_127145
Echinococcus granulosus malate dehydrogenase Get druggable targets OG5_127145 All targets in OG5_127145
Schistosoma japonicum ko:K00026 malate dehydrogenase [EC1.1.1.37B], putative Get druggable targets OG5_127145 All targets in OG5_127145
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Cryptosporidium hominis hypothetical protein Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania mexicana protein kinase, putative,glycogen synthase kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Echinococcus multilocularis cyclin dependent kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma cruzi glycosomal malate dehydrogenase, putative Get druggable targets OG5_127145 All targets in OG5_127145
Onchocerca volvulus Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma cruzi cdc2-related kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma cruzi CYC2-like cyclin, putative Get druggable targets OG5_126649 All targets in OG5_126649
Giardia lamblia G2/mitotic-specific cyclin B Get druggable targets OG5_126649 All targets in OG5_126649
Schistosoma japonicum ko:K05868 cyclin B, putative Get druggable targets OG5_134175 All targets in OG5_134175
Leishmania major cell division related protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus multilocularis cyclin dependent kinase Get druggable targets OG5_126712 All targets in OG5_126712
Plasmodium knowlesi Cell division control protein 2 homolog Get druggable targets OG5_126712 All targets in OG5_126712
Candida albicans hypothetical protein Get druggable targets OG5_126649 All targets in OG5_126649
Trichomonas vaginalis cyclin B, putative Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania major cell division protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania major malate dehydrogenase Get druggable targets OG5_127145 All targets in OG5_127145
Leishmania infantum mitochondrial malate dehydrogenase Get druggable targets OG5_127145 All targets in OG5_127145
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126649 All targets in OG5_126649
Entamoeba histolytica cell division protein kinase 2, putative Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma brucei protein kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Cryptosporidium parvum hypothetical protein Get druggable targets OG5_126888 All targets in OG5_126888
Trichomonas vaginalis cyclins, putative Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma brucei gambiense mitochondrial malate dehydrogenase, putative Get druggable targets OG5_127145 All targets in OG5_127145
Trypanosoma brucei cdc2-related kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Plasmodium berghei glycogen synthase kinase 3, putative Get druggable targets OG5_126888 All targets in OG5_126888
Trypanosoma congolense glycosomal malate dehydrogenase, putative Get druggable targets OG5_127145 All targets in OG5_127145
Trichomonas vaginalis cyclin B, putative Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma congolense mitotic cyclin 6 Get druggable targets OG5_126649 All targets in OG5_126649
Echinococcus multilocularis protein kinase shaggy Get druggable targets OG5_126888 All targets in OG5_126888
Candida albicans similar to all three S. cerevisiae malate dehydrogenases (YKL085W, YDL078C, YOL126C) Get druggable targets OG5_127145 All targets in OG5_127145
Leishmania infantum cell division related protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma cruzi cdc2-related kinase 3 Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma brucei gambiense glycosomal malate dehydrogenase, putative Get druggable targets OG5_127145 All targets in OG5_127145
Leishmania major cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Candida albicans similar to S. cerevisiae MDH1 (YKL085W) mitochondrial malate dehydrogenase Get druggable targets OG5_127145 All targets in OG5_127145
Trypanosoma cruzi cdc2-related kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma congolense mitochondrial malate dehydrogenase Get druggable targets OG5_127145 All targets in OG5_127145
Leishmania braziliensis CYC2-like cyclin, putative,cyclin 6, putative Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma congolense cdc2-related kinase 3, putative Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Onchocerca volvulus Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania infantum malate dehydrogenase Get druggable targets OG5_127145 All targets in OG5_127145
Schistosoma japonicum ko:K08822 glycogen synthase kinase 3 alpha, putative Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania donovani cdc2-related kinase 3, putative Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) CMGC/GSK protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Schistosoma mansoni malate dehydrogenase Get druggable targets OG5_127145 All targets in OG5_127145
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Candida albicans likely G2 B-type cyclin similar to S. cerevisiae CLB1 (YPR119W) which is involved in mitotic induction Get druggable targets OG5_126649 All targets in OG5_126649
Echinococcus multilocularis glycogen synthase kinase 3 beta Get druggable targets OG5_126888 All targets in OG5_126888
Entamoeba histolytica protein kinase domain containing protein Get druggable targets OG5_126888 All targets in OG5_126888
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126649 All targets in OG5_126649
Trichomonas vaginalis cyclins, putative Get druggable targets OG5_126649 All targets in OG5_126649
Candida albicans hypothetical protein Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania major CYC2-like cyclin, putative,cyclin 6, putative Get druggable targets OG5_126649 All targets in OG5_126649
Neospora caninum CMGC kinase, CDK family TgPK2, putative Get druggable targets OG5_126712 All targets in OG5_126712
Cryptosporidium hominis cdc2-like protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Plasmodium yoelii Protein kinase domain, putative Get druggable targets OG5_126888 All targets in OG5_126888
Trichomonas vaginalis cyclins, putative Get druggable targets OG5_126649 All targets in OG5_126649
Candida albicans likely B-type cyclin similar to S. cerevisiae CLB4 (YLR210W) and CLB3 (YDL155W) involved in G1/S transition Get druggable targets OG5_126649 All targets in OG5_126649
Candida albicans Serine/threonine protein kinase required for induction of IME2 by Ime1p Get druggable targets OG5_126888 All targets in OG5_126888
Trichomonas vaginalis cyclin B, putative Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania braziliensis malate dehydrogenase Get druggable targets OG5_127145 All targets in OG5_127145
Schistosoma japonicum ko:K02090 cyclin-dependent kinase 5, putative Get druggable targets OG5_126712 All targets in OG5_126712
Theileria parva glycogen synthase kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Brugia malayi Protein kinase domain containing protein Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis cyclins, putative Get druggable targets OG5_126649 All targets in OG5_126649
Echinococcus granulosus malate dehydrogenase Get druggable targets OG5_127145 All targets in OG5_127145
Echinococcus granulosus glycogen synthase kinase 3 beta Get druggable targets OG5_126888 All targets in OG5_126888
Loa Loa (eye worm) CMGC/GSK protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania braziliensis protein kinase, putative,glycogen synthase kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania infantum cell division protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania infantum glycogen synthase kinase 3 Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania mexicana malate dehydrogenase Get druggable targets OG5_127145 All targets in OG5_127145
Giardia lamblia Kinase, CMGC CDK Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma brucei gambiense cell division related protein kinase 2, putative,CDC2-related protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus multilocularis malate dehydrogenase Get druggable targets OG5_127145 All targets in OG5_127145
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania braziliensis cell division protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus granulosus cyclin dependent kinase 5 Get druggable targets OG5_126712 All targets in OG5_126712
Candida albicans likely G2 B-type cyclin similar to S. cerevisiae CLB1 (YPR119W) which is involved in mitotic induction Get druggable targets OG5_126649 All targets in OG5_126649
Plasmodium berghei cdc2-related kinase 2 Get druggable targets OG5_126712 All targets in OG5_126712
Brugia malayi cell division control protein 2 homolog Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma congolense Cyclin, N-terminal domain/Cyclin, C-terminal domain containing protein, putative Get druggable targets OG5_126649 All targets in OG5_126649
Giardia lamblia Kinase, CMGC GSK Get druggable targets OG5_126888 All targets in OG5_126888
Schistosoma japonicum ko:K02087 cyclin-dependent kinase 1, putative Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma brucei mitotic cyclin 6 Get druggable targets OG5_126649 All targets in OG5_126649
Brugia malayi Cyclin, N-terminal domain containing protein Get druggable targets OG5_126649 All targets in OG5_126649
Brugia malayi Cyclin, N-terminal domain containing protein Get druggable targets OG5_134175 All targets in OG5_134175
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania mexicana CYC2-like cyclin, putative,cyclin 6, putative Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma cruzi cdc2-related kinase 3 Get druggable targets OG5_126712 All targets in OG5_126712
Candida albicans similar to S. cerevisiae MDH3 (YDL078C) peroxisomal malate dehydrogenase Get druggable targets OG5_127145 All targets in OG5_127145
Leishmania mexicana cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma brucei gambiense protein kinase, putative,glycogen synthase kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Trypanosoma cruzi cyclin 6, putative Get druggable targets OG5_126649 All targets in OG5_126649
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Giardia lamblia Kinase, CMGC CDK Get druggable targets OG5_126712 All targets in OG5_126712
Candida albicans second truncated form of RIM11 Serine/threonine protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus multilocularis cyclin B Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma cruzi malate dehydrogenase, putative Get druggable targets OG5_127145 All targets in OG5_127145
Leishmania donovani cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Theileria parva cell division control protein 2 related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania braziliensis cell division related protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) malate dehydrogenase Get druggable targets OG5_127145 All targets in OG5_127145
Trypanosoma brucei gambiense cyclin 6,mitotic cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Echinococcus multilocularis cyclin dependent kinase 5 Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania infantum cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Echinococcus multilocularis G2:mitotic specific cyclin B3 Get druggable targets OG5_134175 All targets in OG5_134175
Leishmania donovani glycogen synthase kinase 3, putative Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania mexicana glycosomal malate dehydrogenase Get druggable targets OG5_127145 All targets in OG5_127145
Trichomonas vaginalis cyclins, putative Get druggable targets OG5_126649 All targets in OG5_126649
Cryptosporidium parvum cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Brugia malayi intracellular kinase Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania donovani malate dehydrogenase Get druggable targets OG5_127145 All targets in OG5_127145
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126649 All targets in OG5_126649
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Plasmodium falciparum L-lactate dehydrogenase malate dehydrogenase 2, NAD (mitochondrial) 296 aa 319 aa 24.1 %
Trypanosoma brucei mitogen-activated protein kinase 5 cyclin-dependent kinase 3 305 aa 303 aa 32.0 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis malate dehydrogenase, putative 0.0022 0.0165 0.068
Trypanosoma cruzi cyclin 6, putative 0.0124 0.2428 1
Echinococcus granulosus zinc finger protein 0.0025 0.0243 0.0214
Trichomonas vaginalis cyclins, putative 0.0064 0.1107 0.4557
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.085 0.3501
Trypanosoma cruzi glycosomal malate dehydrogenase, putative 0.0043 0.0642 0.2547
Leishmania major cytosolic malate dehydrogenase 0.0022 0.0165 0.0558
Giardia lamblia Kinase, CMGC CDK 0.0053 0.085 0.3416
Echinococcus multilocularis cyclin b3 0.0064 0.1107 0.108
Schistosoma mansoni cyclin B 0.0124 0.2428 0.2405
Echinococcus granulosus L lactate dehydrogenase B chain 0.0022 0.0165 0.0136
Echinococcus multilocularis G1:S specific cyclin D1 0.0016 0.0031 0.0002
Brugia malayi Protein kinase domain containing protein 0.0053 0.085 0.2028
Echinococcus granulosus cyclin 0.0016 0.0031 0.0002
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0223 0.1255
Leishmania major cyclin 0.0124 0.2428 1
Toxoplasma gondii lactate dehydrogenase LDH1 0.0022 0.0165 0.0578
Brugia malayi PHD-finger family protein 0.0031 0.0372 0.0845
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0024 0.0223 0.1255
Schistosoma mansoni malate dehydrogenase 0.0022 0.0165 0.0136
Echinococcus multilocularis cyclin 0.0016 0.0031 0.0002
Echinococcus multilocularis Cyclin L1 0.0016 0.0031 0.0002
Trichomonas vaginalis cyclin D, putative 0.0064 0.1107 0.4557
Schistosoma mansoni malate dehydrogenase 0.0022 0.0165 0.0136
Loa Loa (eye worm) hypothetical protein 0.0018 0.0088 0.0141
Brugia malayi Probable malate dehydrogenase, mitochondrial precursor 0.0043 0.0642 0.1512
Schistosoma mansoni hypothetical protein 0.0016 0.0031 0.0002
Trichomonas vaginalis cyclin B3, putative 0.0016 0.0031 0.013
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0031 0.013
Brugia malayi Cyclin, N-terminal domain containing protein 0.0124 0.2428 0.5938
Echinococcus multilocularis cyclin dependent kinase 0.0053 0.085 0.0823
Giardia lamblia Kinase, CMGC GSK 0.0059 0.0981 0.3961
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.004 0.0562 0.0533
Schistosoma mansoni aldehyde dehydrogenase 0.0067 0.1163 0.1137
Echinococcus granulosus cyclin B3 1 0.0064 0.1107 0.108
Entamoeba histolytica malate dehydrogenase, putative 0.0022 0.0165 0.0558
Giardia lamblia Hypothetical protein 0.0064 0.1107 0.4486
Loa Loa (eye worm) hypothetical protein 0.0124 0.2428 0.5938
Echinococcus multilocularis cytosolic malate dehydrogenase 0.0022 0.0165 0.0136
Echinococcus granulosus lactate dehydrogenase a 0.0022 0.0165 0.0136
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0223 0.08
Schistosoma mansoni serine/threonine protein kinase 0.0053 0.085 0.0823
Leishmania major malate dehydrogenase, putative 0.0022 0.0165 0.0558
Echinococcus granulosus cytosolic malate dehydrogenase 0.0022 0.0165 0.0136
Trichomonas vaginalis cyclin B, putative 0.0016 0.0031 0.013
Trichomonas vaginalis cyclin D, putative 0.0064 0.1107 0.4557
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0132 0.2596 0.2574
Schistosoma mansoni zinc finger protein 0.0017 0.0061 0.0031
Onchocerca volvulus 0.0059 0.0981 0.3961
Echinococcus granulosus cyclins 0.0064 0.1107 0.108
Schistosoma mansoni proteasome subunit alpha 1 (T01 family) 0.0016 0.0031 0.0002
Schistosoma mansoni cyclin k 0.0016 0.0031 0.0002
Echinococcus granulosus cyclin b3 0.0064 0.1107 0.108
Trichomonas vaginalis malate dehydrogenase, putative 0.0022 0.0165 0.068
Schistosoma mansoni Cyclin fold protein 0.0016 0.0031 0.0002
Echinococcus granulosus protein kinase shaggy 0.0059 0.0981 0.0954
Echinococcus granulosus G1:S specific cyclin D1 0.0016 0.0031 0.0002
Trypanosoma cruzi glycosomal malate dehydrogenase, putative 0.0043 0.0642 0.2547
Trichomonas vaginalis cyclin B, putative 0.0124 0.2428 1
Trichomonas vaginalis cyclins, putative 0.0124 0.2428 1
Echinococcus multilocularis lactate dehydrogenase a 0.0022 0.0165 0.0136
Echinococcus multilocularis cyclins 0.0064 0.1107 0.108
Plasmodium falciparum acyl-CoA synthetase 0.0018 0.0088 0.0528
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.004 0.0562 0.0533
Echinococcus granulosus cyclin B 0.0124 0.2428 0.2405
Entamoeba histolytica protein kinase domain containing protein 0.0059 0.0981 0.3961
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0223 0.1255
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0067 0.1163 0.1137
Trypanosoma cruzi cytosolic malate dehydrogenase, putative 0.0022 0.0165 0.0558
Echinococcus granulosus cyclins 0.0064 0.1107 0.108
Trichomonas vaginalis malate dehydrogenase, putative 0.0022 0.0165 0.068
Leishmania major hypothetical protein, conserved 0.0017 0.0061 0.0123
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.0059 0.0981 0.4106
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.085 0.3501
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0019 0.0113 0.0084
Echinococcus granulosus cyclin k 0.0016 0.0031 0.0002
Echinococcus granulosus cytosolic malate dehydrogenase 0.0022 0.0165 0.0136
Echinococcus multilocularis cyclins 0.0064 0.1107 0.108
Plasmodium vivax malate dehydrogenase, putative 0.0022 0.0165 0.1409
Toxoplasma gondii malate dehydrogenase MDH 0.0022 0.0165 0.0578
Echinococcus multilocularis zinc finger protein 0.0025 0.0243 0.0214
Plasmodium falciparum glycogen synthase kinase 3 0.0059 0.0981 0.8829
Schistosoma mansoni cyclin l 0.0016 0.0031 0.0002
Echinococcus multilocularis lactate dehydrogenase a 0.0022 0.0165 0.0136
Trypanosoma cruzi CYC2-like cyclin, putative 0.0124 0.2428 1
Trypanosoma cruzi malate dehydrogenase, putative 0.0043 0.0642 0.2547
Trichomonas vaginalis conserved hypothetical protein 0.0064 0.1107 0.4557
Giardia lamblia Kinase, CMGC CDK 0.0053 0.085 0.3416
Loa Loa (eye worm) hypothetical protein 0.0018 0.0088 0.0141
Loa Loa (eye worm) malate dehydrogenase 0.0043 0.0642 0.1512
Plasmodium falciparum malate dehydrogenase 0.0022 0.0165 0.1244
Echinococcus multilocularis cyclin dependent kinase 1 0.0053 0.085 0.0823
Mycobacterium tuberculosis Probable malate dehydrogenase Mdh 0.0022 0.0165 0.09
Brugia malayi intracellular kinase 0.0059 0.0981 0.2352
Schistosoma mansoni cpg binding protein 0.0062 0.106 0.1033
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0059 0.0981 0.2352
Schistosoma mansoni L-lactate dehydrogenase 0.0022 0.0165 0.0136
Plasmodium falciparum cyclin 0.0064 0.1107 1
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0028 0.0315 0.0286
Trichomonas vaginalis malate and lactate dehydrogenase, putative 0.0022 0.0165 0.068
Mycobacterium ulcerans aldehyde dehydrogenase 0.0067 0.1163 1
Brugia malayi Cyclin, N-terminal domain containing protein 0.0124 0.2428 0.5938
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.002 0.0133 0.0104
Loa Loa (eye worm) hypothetical protein 0.0078 0.1406 0.3406
Loa Loa (eye worm) hypothetical protein 0.0018 0.0088 0.0141
Trichomonas vaginalis cyclins, putative 0.0075 0.1353 0.5572
Echinococcus multilocularis cdk5 and abl1 enzyme substrate 1 0.0016 0.0031 0.0002
Brugia malayi Cyclin, N-terminal domain containing protein 0.0199 0.4067 1
Schistosoma mansoni hypothetical protein 0.0017 0.0061 0.0031
Trichomonas vaginalis malate and lactate dehydrogenase, putative 0.0022 0.0165 0.068
Echinococcus multilocularis G2:mitotic specific cyclin B3 0.0199 0.4067 0.405
Brugia malayi CXXC zinc finger family protein 0.0062 0.106 0.2548
Entamoeba histolytica cyclin family protein 0.0064 0.1107 0.4486
Echinococcus granulosus fetal alzheimer antigen falz 0.0028 0.0315 0.0286
Onchocerca volvulus 0.0024 0.0223 0.08
Echinococcus granulosus lactate dehydrogenase a 0.0022 0.0165 0.0136
Entamoeba histolytica malate dehydrogenase, putative 0.0022 0.0165 0.0558
Schistosoma mansoni methyl-cpg binding protein mbd 0.0019 0.0103 0.0074
Trypanosoma brucei glycosomal malate dehydrogenase 0.0043 0.0642 0.2547
Loa Loa (eye worm) hypothetical protein 0.0042 0.0621 0.146
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0053 0.085 0.3416
Toxoplasma gondii hypothetical protein 0.0049 0.0765 0.3171
Loa Loa (eye worm) hypothetical protein 0.0018 0.0088 0.0141
Brugia malayi cell division control protein 2 homolog 0.0053 0.085 0.2028
Entamoeba histolytica malate dehydrogenase,cytoplasmic, putative 0.0022 0.0165 0.0558
Echinococcus multilocularis cyclin G2 0.0016 0.0031 0.0002
Trypanosoma cruzi cyclin, putative 0.0124 0.2428 1
Loa Loa (eye worm) hypothetical protein 0.0045 0.0678 0.1603
Loa Loa (eye worm) hypothetical protein 0.0051 0.0803 0.1911
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0223 0.0475
Plasmodium vivax protein kinase Crk2 0.0053 0.085 0.8624
Echinococcus multilocularis lactate dehydrogenase a 0.0022 0.0165 0.0136
Echinococcus multilocularis cyclin t1 0.0016 0.0031 0.0002
Onchocerca volvulus 0.0124 0.2428 1
Trichomonas vaginalis cyclins, putative 0.0016 0.0031 0.013
Echinococcus granulosus lactate dehydrogenase protein 0.0022 0.0165 0.0136
Entamoeba histolytica cyclin, putative 0.0064 0.1107 0.4486
Echinococcus multilocularis cyclins 0.0064 0.1107 0.108
Trypanosoma cruzi cdc2-related kinase 3 0.0053 0.085 0.3416
Trypanosoma cruzi ISWI complex protein 0.0017 0.0061 0.0123
Echinococcus granulosus cyclin dependent kinase 5 0.0053 0.085 0.0823
Mycobacterium ulcerans malate dehydrogenase 0.0022 0.0165 0.0715
Schistosoma mansoni malate dehydrogenase 0.0022 0.0165 0.0136
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.0059 0.0981 0.0954
Plasmodium vivax lactate dehydrogenase 0.0022 0.0165 0.1409
Echinococcus multilocularis cyclins 0.0064 0.1107 0.108
Trichomonas vaginalis cyclins, putative 0.0016 0.0031 0.013
Echinococcus granulosus cyclins 0.0064 0.1107 0.108
Trichomonas vaginalis malate dehydrogenase, putative 0.0022 0.0165 0.068
Brugia malayi F/Y-rich N-terminus family protein 0.0021 0.0154 0.0305
Trichomonas vaginalis malate dehydrogenase, putative 0.0022 0.0165 0.068
Trichomonas vaginalis cyclin B, putative 0.0124 0.2428 1
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0024 0.0223 0.1429
Echinococcus multilocularis cyclin y 0.0016 0.0031 0.0002
Echinococcus granulosus methyl CpG binding domain protein 2 0.0019 0.0103 0.0074
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0223 0.08
Giardia lamblia Kinase, CMGC GSK 0.0059 0.0981 0.3961
Echinococcus granulosus cpg binding protein 0.0068 0.1184 0.1158
Loa Loa (eye worm) hypothetical protein 0.0024 0.0223 0.0475
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0069 0.1217 0.119
Trichomonas vaginalis malate and lactate dehydrogenase, putative 0.0022 0.0165 0.068
Toxoplasma gondii aldehyde dehydrogenase 0.0067 0.1163 0.4896
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0067 0.1163 1
Trichomonas vaginalis CMGC family protein kinase 0.0059 0.0981 0.4039
Echinococcus multilocularis cyclins 0.0064 0.1107 0.108
Chlamydia trachomatis malate dehydrogenase 0.0022 0.0165 1
Trichomonas vaginalis cyclin B, putative 0.0064 0.1107 0.4557
Schistosoma mansoni methyl-cpg binding protein mbd 0.0019 0.0103 0.0074
Entamoeba histolytica cyclin family protein 0.0064 0.1107 0.4486
Echinococcus multilocularis protein kinase shaggy 0.0059 0.0981 0.0954
Schistosoma mansoni cyclin G2 0.0016 0.0031 0.0002
Entamoeba histolytica protein kinase domain containing protein 0.0059 0.0981 0.3961
Echinococcus granulosus malate dehydrogenase 0.0043 0.0642 0.0614
Loa Loa (eye worm) cytochrome P450 family protein 0.0034 0.0438 0.1007
Loa Loa (eye worm) hypothetical protein 0.002 0.0133 0.0253
Trichomonas vaginalis malate dehydrogenase, putative 0.0022 0.0165 0.068
Toxoplasma gondii lactate dehydrogenase LDH2 0.0022 0.0165 0.0578
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0223 0.1255
Trichomonas vaginalis malate dehydrogenase, putative 0.0022 0.0165 0.068
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0053 0.085 0.3541
Trypanosoma brucei cdc2-related kinase 3 0.0053 0.085 0.3416
Plasmodium vivax acyl-CoA synthetase, putative 0.0018 0.0088 0.0598
Trypanosoma cruzi cytosolic malate dehydrogenase, putative 0.0022 0.0165 0.0558
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0223 0.0475
Schistosoma mansoni cpg binding protein 0.0068 0.1184 0.1158
Entamoeba histolytica cell division protein kinase 2, putative 0.0053 0.085 0.3416
Plasmodium vivax glycogen synthase kinase 3, putative 0.0059 0.0981 1
Schistosoma mansoni cyclins 0.0064 0.1107 0.108
Echinococcus multilocularis cyclin B3 1 0.0064 0.1107 0.108
Entamoeba histolytica cyclin, putative 0.0124 0.2428 1
Toxoplasma gondii histone lysine methyltransferase SET1 0.012 0.2343 1
Trypanosoma brucei cytosolic malate dehydrogenase 0.0022 0.0165 0.0558
Brugia malayi Bromodomain containing protein 0.0086 0.1588 0.3857
Schistosoma mansoni cyclin G 0.0016 0.0031 0.0002
Echinococcus multilocularis oligomeric golgi complex subunit 3 0.0016 0.0031 0.0002
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.0059 0.0981 0.3961
Trypanosoma cruzi mitochondrial malate dehydrogenase, putative 0.0043 0.0642 0.2547
Echinococcus multilocularis cyclin A3 4 0.0016 0.0031 0.0002
Echinococcus granulosus cyclin G2 0.0016 0.0031 0.0002
Schistosoma mansoni cyclin B3 0.0199 0.4067 0.405
Loa Loa (eye worm) bromodomain containing protein 0.0019 0.0118 0.0215
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.0223 1
Plasmodium falciparum lactate dehydrogenase, putative 0.0022 0.0165 0.1244
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0031 0.013
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0019 0.0113 0.0084
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0067 0.1163 0.1137
Trypanosoma brucei ISWI complex protein 0.0017 0.0061 0.0123
Echinococcus granulosus cyclin A3 4 0.0016 0.0031 0.0002
Schistosoma mansoni serine/threonine protein kinase 0.0053 0.085 0.0823
Echinococcus multilocularis cpg binding protein 0.0068 0.1184 0.1158
Giardia lamblia Cyclin A 0.0064 0.1107 0.4486
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0053 0.085 0.2028
Entamoeba histolytica acyl-coA synthetase, putative 0.0024 0.0223 0.08
Trichomonas vaginalis cyclin B, putative 0.0016 0.0031 0.013
Trypanosoma brucei protein kinase, putative 0.0059 0.0981 0.3961
Trichomonas vaginalis malate and lactate dehydrogenase, putative 0.0022 0.0165 0.068
Loa Loa (eye worm) PHD-finger family protein 0.0023 0.019 0.0394
Trichomonas vaginalis malate dehydrogenase, putative 0.0022 0.0165 0.068
Trichomonas vaginalis cyclin D, putative 0.0016 0.0031 0.013
Mycobacterium ulcerans hypothetical protein 0.0024 0.0223 0.1255
Giardia lamblia Malate dehydrogenase 0.0022 0.0165 0.0558
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0024 0.0223 0.1255
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.0223 1
Trypanosoma cruzi malate dehydrogenase, putative 0.0022 0.0165 0.0558
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0024 0.0223 0.1255
Echinococcus multilocularis malate dehydrogenase 0.0043 0.0642 0.0614
Plasmodium falciparum protein kinase 5 0.0053 0.085 0.7615
Loa Loa (eye worm) hypothetical protein 0.0018 0.0088 0.0141
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0028 0.0315 0.0286
Leishmania major mitochondrial malate dehydrogenase 0.0043 0.0642 0.2547
Echinococcus granulosus Cyclin L1 0.0016 0.0031 0.0002
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0053 0.085 0.0823
Trichomonas vaginalis cyclin B3, putative 0.0064 0.1107 0.4557
Trypanosoma brucei cdc2-related kinase 1 0.0053 0.085 0.3416
Brugia malayi Malate dehydrogenase, cytoplasmic 0.0022 0.0165 0.0331
Echinococcus multilocularis cyclin dependent kinase 5 0.0053 0.085 0.0823
Trypanosoma cruzi cyclin, putative 0.0124 0.2428 1
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0024 0.0223 0.1255
Echinococcus granulosus cyclin G2 0.0016 0.0031 0.0002
Trypanosoma brucei mitochondrial malate dehydrogenase 0.0043 0.0642 0.2547
Wolbachia endosymbiont of Brugia malayi malate dehydrogenase 0.0022 0.0165 0.5
Trichomonas vaginalis malate dehydrogenase, putative 0.0022 0.0165 0.068
Echinococcus granulosus cdk5 and abl1 enzyme substrate 1 0.0016 0.0031 0.0002
Trichomonas vaginalis cyclins, putative 0.0124 0.2428 1
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0031 0.013
Schistosoma mansoni cpg binding protein 0.0068 0.1184 0.1158
Mycobacterium ulcerans aldehyde dehydrogenase 0.0067 0.1163 1
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0053 0.085 0.2028
Entamoeba histolytica protein kinase, putative 0.0059 0.0981 0.3961
Giardia lamblia G2/mitotic-specific cyclin B 0.0124 0.2428 1
Trypanosoma brucei malate dehydrogenase-related 0.0022 0.0165 0.0558
Trichomonas vaginalis cyclins, putative 0.0124 0.2428 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.002 0.0133 0.0104
Echinococcus multilocularis cyclin dependent kinase 1 0.0053 0.085 0.0823
Loa Loa (eye worm) hypothetical protein 0.0022 0.0165 0.0331
Echinococcus multilocularis cyclins 0.0064 0.1107 0.108
Loa Loa (eye worm) CXXC zinc finger family protein 0.0062 0.106 0.2548
Schistosoma mansoni g1/s-specific cyclin C 0.0016 0.0031 0.0002
Echinococcus granulosus cyclin dependent kinase 0.0053 0.085 0.0823
Leishmania major glycosomal malate dehydrogenase 0.0043 0.0642 0.2547
Trichomonas vaginalis cyclin A, putative 0.0124 0.2428 1
Echinococcus multilocularis L lactate dehydrogenase B chain 0.0022 0.0165 0.0136
Brugia malayi lactate dehydrogenase. 0.0022 0.0165 0.0331
Loa Loa (eye worm) histone methyltransferase 0.0019 0.0113 0.0203
Loa Loa (eye worm) hypothetical protein 0.0052 0.0826 0.1968
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0223 0.08
Loa Loa (eye worm) malate dehydrogenase 0.0022 0.0165 0.0331
Entamoeba histolytica cell division protein kinase 2, putative 0.0053 0.085 0.3416
Trichomonas vaginalis cyclin B, putative 0.0124 0.2428 1
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.0059 0.0981 0.3961
Leishmania major CYC2-like cyclin, putative,cyclin 6, putative 0.0124 0.2428 1
Schistosoma mansoni hypothetical protein 0.0016 0.0031 0.0002
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0069 0.1217 0.119
Echinococcus granulosus glycogen synthase kinase 3 beta 0.0059 0.0981 0.0954
Mycobacterium ulcerans aldehyde dehydrogenase 0.0067 0.1163 1
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0019 0.0103 0.0074
Trypanosoma brucei mitotic cyclin 6 0.0124 0.2428 1
Echinococcus multilocularis cyclin G2 0.0016 0.0031 0.0002
Trypanosoma cruzi cdc2-related kinase 1 0.0053 0.085 0.3416
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0223 0.08
Echinococcus granulosus cyclin y 0.0016 0.0031 0.0002
Echinococcus granulosus G2:mitotic specific cyclin B3 0.0199 0.4067 0.405
Loa Loa (eye worm) cyclin domain-containing protein 0.0199 0.4067 1
Leishmania major malate dehydrogenase, putative 0.0022 0.0165 0.0558
Echinococcus granulosus cyclin dependent kinase 1 0.0053 0.085 0.0823
Schistosoma mansoni cyclin d 0.0016 0.0031 0.0002
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0053 0.085 0.2028
Echinococcus granulosus oligomeric golgi complex subunit 3 0.0016 0.0031 0.0002
Loa Loa (eye worm) hypothetical protein 0.006 0.1011 0.2427
Leishmania major malate dehydrogenase 0.0043 0.0642 0.2547
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0223 0.08
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.0223 0.1429
Echinococcus multilocularis cyclins 0.0064 0.1107 0.108
Echinococcus granulosus histone lysine methyltransferase setb 0.002 0.0133 0.0104
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0059 0.0981 0.2352
Echinococcus granulosus cyclin t1 0.0016 0.0031 0.0002
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0067 0.1163 0.4723
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.002 0.0133 0.0104
Schistosoma mansoni bromodomain containing protein 0.0073 0.1304 0.1278
Echinococcus multilocularis cyclin y 0.0016 0.0031 0.0002
Brugia malayi Bromodomain containing protein 0.0042 0.0619 0.1456
Schistosoma mansoni malate dehydrogenase 0.0043 0.0642 0.0614
Brugia malayi Cytochrome P450 family protein 0.0034 0.0438 0.1007
Trypanosoma cruzi ISWI complex protein 0.0017 0.0061 0.0123
Onchocerca volvulus 0.0062 0.106 0.4291
Plasmodium falciparum L-lactate dehydrogenase 0.0022 0.0165 0.1244
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0053 0.085 0.3416
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0018 0.0088 0.0199
Schistosoma mansoni L-lactate dehydrogenase 0.0022 0.0165 0.0136
Echinococcus multilocularis cyclin k 0.0016 0.0031 0.0002
Echinococcus multilocularis cyclin B 0.0124 0.2428 0.2405
Plasmodium vivax lactate/malate dehydrogenase, putative 0.0022 0.0165 0.1409
Trichomonas vaginalis cyclin B, putative 0.0124 0.2428 1
Trypanosoma cruzi cdc2-related kinase 3 0.0053 0.085 0.3416
Trichomonas vaginalis malate dehydrogenase, putative 0.0022 0.0165 0.068
Trichomonas vaginalis cyclin B3, putative 0.0016 0.0031 0.013
Echinococcus granulosus cyclin y 0.0016 0.0031 0.0002
Echinococcus multilocularis malate dehydrogenase 0.0043 0.0642 0.0614
Trichomonas vaginalis CMGC family protein kinase 0.0059 0.0981 0.4039
Schistosoma mansoni hypothetical protein 0.0023 0.019 0.0161
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.085 0.3501
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0223 0.0475
Loa Loa (eye worm) hypothetical protein 0.0024 0.0223 0.0475
Trichomonas vaginalis malate dehydrogenase, putative 0.0022 0.0165 0.068
Echinococcus granulosus malate dehydrogenase 0.0043 0.0642 0.0614
Echinococcus multilocularis cytosolic malate dehydrogenase 0.0022 0.0165 0.0136
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0031 0.013
Trypanosoma cruzi cdc2-related kinase 1 0.0053 0.085 0.3416
Loa Loa (eye worm) hypothetical protein 0.0024 0.0223 0.0475
Loa Loa (eye worm) hypothetical protein 0.0124 0.2428 0.5938
Schistosoma mansoni aldehyde dehydrogenase 0.0067 0.1163 0.1137
Schistosoma mansoni zinc finger protein 0.0025 0.0243 0.0214
Trichomonas vaginalis cyclin A, putative 0.0016 0.0031 0.013
Echinococcus multilocularis lactate dehydrogenase protein 0.0022 0.0165 0.0136
Echinococcus granulosus cyclins 0.0064 0.1107 0.108
Trichomonas vaginalis cyclins, putative 0.0124 0.2428 1
Echinococcus granulosus cyclins 0.0064 0.1107 0.108
Echinococcus granulosus cyclins 0.0016 0.0031 0.0002
Trichomonas vaginalis malate dehydrogenase, putative 0.0022 0.0165 0.068
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.0059 0.0981 0.0954

Activities

Activity type Activity value Assay description Source Reference
Activity (binding) = 60.9 % Inhibition of mitochondrial malate dehydrogenase assessed as residual enzyme activity at 10 uM by spectrophotometry ChEMBL. 19906467
GI50 (functional) -7.556 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5.532 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.34 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
IC50 (binding) = 4.2 microM Inhibition of CDK1/cyclin B ChEMBL. 19906467
IC50 (binding) = 7.2 microM Inhibition of GSK3-beta ChEMBL. 19906467
IC50 (binding) = 13.5 microM Inhibition of mitochondrial malate dehydrogenase by spectrophotometry ChEMBL. 19906467

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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