Detailed information for compound 1080840

Basic information

Technical information
  • TDR Targets ID: 1080840
  • Name: 3-[2-fluoro-5-(trifluoromethyl)phenyl]-1-[4-[ 1-methyl-6-(4-pyrrolidin-1-ylbutylamino)pyraz olo[5,4-d]pyrimidin-3-yl]phenyl]urea
  • MW: 570.584 | Formula: C28H30F4N8O
  • H donors: 3 H acceptors: 4 LogP: 4.95 Rotable bonds: 12
    Rule of 5 violations (Lipinski): 2
  • SMILES: O=C(Nc1cc(ccc1F)C(F)(F)F)Nc1ccc(cc1)c1nn(c2c1cnc(n2)NCCCCN1CCCC1)C
  • InChi: 1S/C28H30F4N8O/c1-39-25-21(17-34-26(37-25)33-12-2-3-13-40-14-4-5-15-40)24(38-39)18-6-9-20(10-7-18)35-27(41)36-23-16-19(28(30,31)32)8-11-22(23)29/h6-11,16-17H,2-5,12-15H2,1H3,(H,33,34,37)(H2,35,36,41)
  • InChiKey: ZLVOTHZTCUBWHZ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3-[2-fluoro-5-(trifluoromethyl)phenyl]-1-[4-[1-methyl-6-(4-1-pyrrolidinylbutylamino)-3-pyrazolo[5,4-d]pyrimidinyl]phenyl]urea

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0073 0.0041 0.0474
Entamoeba histolytica hypothetical protein 0.0209 0.0153 0.168
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0073 0.0041 0.0474
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.0073 0.0041 0.0038
Entamoeba histolytica hypothetical protein 0.0043 0.0016 0.0076
Giardia lamblia Kinase, PLK 0.0229 0.0169 0.1954
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0315 0.024 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0597 0.0471 0.5474
Entamoeba histolytica protein kinase domain containing protein 0.0061 0.0031 0.0249
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0073 0.0041 0.0474
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0061 0.0031 0.0272
Trichomonas vaginalis CAMK family protein kinase 0.0229 0.0169 0.1965
Brugia malayi bHLH-PAS transcription factor 0.0043 0.0016 0.019
Trichomonas vaginalis phosphofructokinase, putative 0.0035 0.001 0.0113
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0032 0.0007 0.0086
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0073 0.0041 0.0474
Schistosoma mansoni serine/threonine protein kinase 0.016 0.0112 0.0858
Trichomonas vaginalis CAMK family protein kinase 0.0229 0.0169 0.1965
Trichomonas vaginalis phosphofructokinase, putative 0.0035 0.001 0.0113
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.1029 0.0826 1
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.1072 0.0861 0.2481
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0073 0.0041 0.0474
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0554 0.0435 0.1254
Trichomonas vaginalis casein kinase II beta chain, putative 0.0044 0.0017 0.0196
Loa Loa (eye worm) hypothetical protein 0.0554 0.0435 0.3818
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0209 0.0153 0.1175
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0315 0.024 0.0237
Echinococcus granulosus voltage dependent calcium channel 0.0038 0.0012 0.0009
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0073 0.0041 0.0474
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0209 0.0153 0.044
Leishmania major phosphatidylinositol 3-kinase, putative 0.0957 0.0767 0.2105
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.005 0.0022 0.0063
Schistosoma mansoni voltage-gated cation channel 0.0038 0.0012 0.0073
Trichomonas vaginalis CMGC family protein kinase 0.0164 0.0115 0.134
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0209 0.0153 0.1902
Echinococcus granulosus cyclin dependent kinase 19 0.016 0.0112 0.0109
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0088 0.0053 0.005
Mycobacterium ulcerans putative regulatory protein 0.0043 0.0016 0.0696
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0209 0.0153 0.044
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.1029 0.0826 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0566 0.0446 0.5178
Toxoplasma gondii ck2 beta subunit 0.0044 0.0017 0.021
Trichomonas vaginalis casein kinase II beta chain, putative 0.0044 0.0017 0.0196
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0061 0.0031 0.0272
Toxoplasma gondii target of rapamycin (TOR), putative 0.1001 0.0803 1
Loa Loa (eye worm) phosphatidylinositol 3 0.0209 0.0153 0.134
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0253 0.0189 0.2287
Brugia malayi 6-phosphofructokinase 0.013 0.0088 0.1019
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.1007 0.0808 0.2217
Trichomonas vaginalis phosphofructokinase, putative 0.013 0.0088 0.1018
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.065 0.0514 0.6186
Trichomonas vaginalis PIKK family atypical protein kinase 0.0979 0.0785 0.9115
Schistosoma mansoni serine/threonine protein kinase 0.0384 0.0297 0.2303
Loa Loa (eye worm) phosphatidylinositol 3 0.1029 0.0826 0.7241
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0032 0.0007 0.0086
Onchocerca volvulus 0.0058 0.0028 0.0429
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0209 0.0153 0.015
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0482 0.0377 0.4371
Brugia malayi Cytochrome P450 family protein 0.0036 0.001 0.0118
Entamoeba histolytica hypothetical protein 0.0043 0.0016 0.0076
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0073 0.0041 0.0118
Trichomonas vaginalis PIKK family atypical protein kinase 0.0979 0.0785 0.9116
Plasmodium vivax unspecified product 0.0164 0.0115 0.4818
Loa Loa (eye worm) hypothetical protein 0.0404 0.0313 0.2741
Brugia malayi glutaminase DH11.1 0.0309 0.0235 0.2723
Plasmodium vivax casein kinase II beta chain, putative 0.0044 0.0017 0.0705
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.1579 0.1277 1
Mycobacterium tuberculosis Conserved hypothetical protein 0.0209 0.0153 1
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0315 0.024 0.2783
Onchocerca volvulus 0.0209 0.0153 0.4871
Loa Loa (eye worm) 6-phosphofructokinase 0.013 0.0088 0.077
Trichomonas vaginalis casein kinase II beta chain, putative 0.0044 0.0017 0.0196
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.0038 0.0012 0.0009
Echinococcus multilocularis phosphatidylinositol 3 kinase regulatory subunit 0.0104 0.0066 0.0063
Echinococcus multilocularis protein kinase shaggy 0.0061 0.0031 0.0028
Trichomonas vaginalis conserved hypothetical protein 0.0344 0.0264 0.306
Onchocerca volvulus Serine\/threonine kinase homolog 0.0229 0.0169 0.5458
Brugia malayi PAS domain containing protein 0.0058 0.0029 0.0334
Entamoeba histolytica hypothetical protein 0.0209 0.0153 0.168
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.005 0.0022 0.0253
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.0038 0.0012 0.0009
Echinococcus granulosus expressed protein 0.0447 0.0348 0.0345
Trichomonas vaginalis casein kinase II beta chain, putative 0.0044 0.0017 0.0196
Loa Loa (eye worm) phosphatidylinositol 3 0.1412 0.114 1
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.1018 0.0816 0.0814
Plasmodium vivax 6-phosphofructokinase, putative 0.0035 0.001 0.0407
Toxoplasma gondii casein kinase ii regulatory subunit protein 0.0044 0.0017 0.021
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0073 0.0041 0.0474
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.1029 0.0826 0.2266
Brugia malayi phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative 0.0507 0.0397 0.4609
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0073 0.0041 0.0474
Trichomonas vaginalis phosphofructokinase, putative 0.013 0.0088 0.1018
Trichomonas vaginalis casein kinase II beta chain, putative 0.0044 0.0017 0.0196
Schistosoma mansoni hypothetical protein 0.0209 0.0153 0.1175
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0229 0.0169 0.0166
Loa Loa (eye worm) phosphofructokinase 0.013 0.0088 0.077
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 1.2203 1 1
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0209 0.0153 0.6376
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0209 0.0153 0.015
Schistosoma mansoni single-minded 0.0058 0.0029 0.0201
Schistosoma mansoni protein kinase 0.0164 0.0115 0.0882
Echinococcus multilocularis Zinc finger, PHD finger 0.0315 0.024 0.0237
Trichomonas vaginalis PIKK family atypical protein kinase 0.0554 0.0435 0.5055
Brugia malayi hypothetical protein 0.0283 0.0213 0.2476
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.1029 0.0826 0.0823
Echinococcus multilocularis survival motor neuron protein 1 0.0283 0.0213 0.021
Trichomonas vaginalis PIKK family atypical protein kinase 0.0209 0.0153 0.1774
Echinococcus multilocularis expressed conserved protein 0.0098 0.0061 0.0058
Giardia lamblia Hypothetical protein 0.0209 0.0153 0.1753
Trichomonas vaginalis casein kinase II beta chain, putative 0.0044 0.0017 0.0196
Mycobacterium ulcerans putative regulatory protein 0.0023 0.0000059662 0.0003
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.013 0.0088 0.1063
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0209 0.0153 0.015
Trichomonas vaginalis casein kinase II beta chain, putative 0.0044 0.0017 0.0196
Entamoeba histolytica hypothetical protein 0.0043 0.0016 0.0076
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.0016 0.0104
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.1072 0.0861 1
Toxoplasma gondii phosphofructokinase PFKII 0.0035 0.001 0.0121
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0209 0.0153 0.1774
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0073 0.0041 0.0474
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.0073 0.0041 0.0474
Brugia malayi 6-phosphofructokinase 0.013 0.0088 0.1019
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0027 0.0003 0.0027
Trichomonas vaginalis casein kinase II beta chain, putative 0.0044 0.0017 0.0196
Echinococcus granulosus glycogen synthase kinase 3 beta 0.0061 0.0031 0.0028
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0229 0.0169 0.1484
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0209 0.0153 0.015
Entamoeba histolytica hypothetical protein 0.0209 0.0153 0.168
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0027 0.0003 0.0036
Brugia malayi Csnk2b protein 0.0044 0.0017 0.0197
Trichomonas vaginalis PIKK family atypical protein kinase 0.1029 0.0826 0.9587
Schistosoma mansoni hypothetical protein 0.0043 0.0016 0.0104
Trichomonas vaginalis PIKK family atypical protein kinase 0.1001 0.0803 0.9325
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0404 0.0313 0.031
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.1018 0.0816 0.0814
Trichomonas vaginalis PIKK family atypical protein kinase 0.1001 0.0803 0.9325
Schistosoma mansoni high voltage-activated calcium channel beta subunit 2 0.0104 0.0066 0.0495
Trichomonas vaginalis phosphofructokinase, putative 0.013 0.0088 0.1018
Mycobacterium leprae conserved hypothetical protein 0.0209 0.0153 1
Onchocerca volvulus 0.0059 0.003 0.0472
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0035 0.001 0.0407
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.0073 0.0041 0.0038
Echinococcus granulosus serine protein kinase ATM 0.0571 0.045 0.0447
Loa Loa (eye worm) hypothetical protein 0.0023 0.0000059662 0.0001
Entamoeba histolytica hypothetical protein 0.0905 0.0724 0.8392
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0038 0.0012 0.0009
Trichomonas vaginalis conserved hypothetical protein 0.0404 0.0313 0.3629
Trichomonas vaginalis casein kinase II beta chain, putative 0.0044 0.0017 0.0196
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0038 0.0012 0.0009
Trichomonas vaginalis PIKK family atypical protein kinase 0.1001 0.0803 0.9325
Loa Loa (eye worm) phosphatidylinositol kinase 0.0209 0.0153 0.134
Echinococcus granulosus expressed conserved protein 0.0098 0.0061 0.0058
Trichomonas vaginalis conserved hypothetical protein 0.0064 0.0034 0.0389
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0035 0.001 0.0407
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.005 0.0022 0.0253
Entamoeba histolytica hypothetical protein 0.0571 0.045 0.5168
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.097 0.0778 0.9417
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.1072 0.0861 1
Echinococcus granulosus tumor protein p63 0.0404 0.0313 0.031
Leishmania major ATP-dependent phosphofructokinase 0.013 0.0088 0.0241
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.0209 0.0153 0.168
Trichomonas vaginalis phosphofructokinase, putative 0.0035 0.001 0.0113
Trichomonas vaginalis casein kinase II beta chain, putative 0.0044 0.0017 0.0196
Echinococcus multilocularis cyclin dependent kinase 19 0.016 0.0112 0.0109
Plasmodium falciparum glycogen synthase kinase 3 0.0061 0.0031 0.1293
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.0209 0.0153 0.6376
Trypanosoma cruzi polo-like protein kinase, putative 0.0229 0.0169 0.0488
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0073 0.0041 0.0474
Brugia malayi hypothetical protein 0.0043 0.0016 0.0189
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.1072 0.0861 1
Loa Loa (eye worm) CMGC/CK2 protein kinase 0.0164 0.0115 0.1013
Leishmania major phosphatidylinositol 3-kinase, putative 0.0315 0.024 0.0658
Schistosoma mansoni cellular tumor antigen P53 0.0059 0.003 0.0207
Echinococcus granulosus nuclear factor of activated T cells 5 0.0088 0.0053 0.005
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0073 0.0041 0.0118
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.013 0.0088 0.574
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0032 0.0007 0.0086
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.0061 0.0031 0.0028
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0027 0.0003 0.0027
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0315 0.024 0.069
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0554 0.0435 0.5056
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0315 0.024 0.1857
Trichomonas vaginalis phosphofructokinase, putative 0.013 0.0088 0.1018
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.0038 0.0012 0.0073
Echinococcus multilocularis proto oncogene serine:threonine protein kinase 0.0384 0.0297 0.0294
Schistosoma mansoni aryl hydrocarbon receptor 0.0058 0.0029 0.0201
Giardia lamblia GTOR 0.1029 0.0826 1
Loa Loa (eye worm) hypothetical protein 0.0032 0.0007 0.0065
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0073 0.0041 0.0474
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0209 0.0153 0.044
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0362 0.0278 0.0801
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.1029 0.0826 0.0823
Loa Loa (eye worm) hypothetical protein 0.0335 0.0256 0.2243
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0073 0.0041 0.0474
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0229 0.0169 0.0166
Trichomonas vaginalis PIKK family atypical protein kinase 0.0957 0.0767 0.8906
Trichomonas vaginalis PIKK family atypical protein kinase 0.1007 0.0808 0.9378
Echinococcus multilocularis serine protein kinase ATM 0.0571 0.045 0.0447
Trichomonas vaginalis PIKK family atypical protein kinase 0.1029 0.0826 0.9587
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0032 0.0007 0.0086
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0209 0.0153 0.6376
Trichomonas vaginalis PIKK family atypical protein kinase 0.0957 0.0767 0.8906
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0571 0.045 0.5447
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0539 0.0423 0.3299
Echinococcus multilocularis casein kinase ii subunit alpha 0.0164 0.0115 0.0112
Giardia lamblia Phosphatidylinositol 4-kinase 0.0209 0.0153 0.1753
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0038 0.0012 0.0009
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0073 0.0041 0.0474
Brugia malayi MH2 domain containing protein 0.0135 0.0092 0.1065
Trichomonas vaginalis CAMK family protein kinase 0.0115 0.0076 0.0877
Plasmodium vivax glycogen synthase kinase 3, putative 0.0061 0.0031 0.1293
Toxoplasma gondii CMGC kinase, CK2 family 0.0164 0.0115 0.1438
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0905 0.0724 0.8392
Entamoeba histolytica protein kinase domain containing protein 0.0164 0.0115 0.1241
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0058 0.0028 0.0329
Loa Loa (eye worm) phosphatidylinositol 3 0.0209 0.0153 0.134
Trichomonas vaginalis PIKK family atypical protein kinase 0.0979 0.0785 0.9115
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.0209 0.0153 0.1851
Loa Loa (eye worm) phosphatidylinositol 3 0.0209 0.0153 0.134
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.0038 0.0012 0.0009
Leishmania major casein kinase II, putative 0.0164 0.0115 0.0317
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0482 0.0377 0.1084
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0209 0.0153 0.1774
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0315 0.024 0.069
Entamoeba histolytica protein kinase domain containing protein 0.0061 0.0031 0.0249
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.013 0.0088 0.0253
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0957 0.0767 0.9289
Trichomonas vaginalis phosphofructokinase, putative 0.0035 0.001 0.0113
Echinococcus granulosus casein kinase ii subunit alpha 0.0164 0.0115 0.0112
Trichomonas vaginalis glutaminase, putative 0.0309 0.0235 0.2723
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.0061 0.0031 0.0219
Loa Loa (eye worm) transcription factor SMAD2 0.0135 0.0092 0.0804
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0073 0.0041 0.0495
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.1579 0.1277 0.1274
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0817 0.0651 0.7563
Trichomonas vaginalis PIKK family atypical protein kinase 0.0985 0.079 0.9169
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0792 0.0631 0.0628
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0635 0.0502 0.6086
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0566 0.0446 0.5123
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0073 0.0041 0.0474
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0209 0.0153 0.1774
Brugia malayi phosphofructokinase 0.013 0.0088 0.1019
Trichomonas vaginalis CAMK family protein kinase 0.0229 0.0169 0.1965
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.1029 0.0826 0.9583
Echinococcus granulosus survival motor neuron protein 1 0.0283 0.0213 0.021
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.0016 0.0013
Echinococcus multilocularis casein kinase ii subunit beta 0.0044 0.0017 0.0014
Leishmania major phosphatidylinositol kinase, putative 0.0209 0.0153 0.0419
Trichomonas vaginalis PIKK family atypical protein kinase 0.1007 0.0808 0.9378
Trichomonas vaginalis conserved hypothetical protein 0.0064 0.0034 0.0389
Trichomonas vaginalis PIKK family atypical protein kinase 0.0571 0.045 0.5222
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0073 0.0041 0.0474
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0073 0.0041 0.0474
Schistosoma mansoni hypothetical protein 0.0404 0.0313 0.2429
Mycobacterium ulcerans two component sensor histidine kinase DevS 0.0023 0.0000059662 0.0003
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0209 0.0153 0.044
Schistosoma mansoni glutaminase 0.0309 0.0235 0.1817
Trichomonas vaginalis PIKK family atypical protein kinase 0.1007 0.0808 0.9378
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0554 0.0435 0.0432
Leishmania major hypothetical protein, unknown function 0.0209 0.0153 0.0419
Trichomonas vaginalis casein kinase II beta chain, putative 0.0044 0.0017 0.0196
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.1072 0.0861 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0957 0.0767 0.8906
Schistosoma mansoni 6-phosphofructokinase 0.013 0.0088 0.0664
Trypanosoma cruzi casein kinase II, putative 0.0164 0.0115 0.0333
Trichomonas vaginalis PIKK family atypical protein kinase 0.0597 0.0471 0.5474
Brugia malayi PXA domain containing protein 0.0025 0.0001 0.0014
Entamoeba histolytica protein kinase rad3, putative 0.0554 0.0435 0.4999
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0283 0.0213 0.1869
Trichomonas vaginalis PIKK family atypical protein kinase 0.0957 0.0767 0.8906
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.1018 0.0816 0.948
Trichomonas vaginalis CAMK family protein kinase 0.0229 0.0169 0.1965
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.1018 0.0816 0.2352
Onchocerca volvulus 0.0209 0.0153 0.4871
Trichomonas vaginalis casein kinase II beta chain, putative 0.0044 0.0017 0.0196
Onchocerca volvulus Serine\/threonine protein kinase homolog 0.0384 0.0297 1
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0315 0.024 0.0237
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0035 0.001 0.5
Echinococcus multilocularis voltage dependent calcium channel 0.0038 0.0012 0.0009
Trichomonas vaginalis CMGC family protein kinase 0.0061 0.0031 0.036
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.0016 0.0013
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0315 0.024 0.2699
Trichomonas vaginalis PIKK family atypical protein kinase 0.1029 0.0826 0.9587
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.1018 0.0816 0.2352
Loa Loa (eye worm) hypothetical protein 0.0195 0.0141 0.1239
Schistosoma mansoni serine/threonine protein kinase 0.0229 0.0169 0.1304
Brugia malayi follicle stimulating hormone receptor 0.0283 0.0213 0.2475
Trypanosoma brucei protein kinase, putative 0.0061 0.0031 0.0376
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.0061 0.0031 0.0089
Loa Loa (eye worm) phosphatidylinositol 3 0.0209 0.0153 0.134
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.0032 0.0007 0.0034
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.097 0.0778 0.0775
Entamoeba histolytica phosphofructokinase, putative 0.013 0.0088 0.0915
Plasmodium vivax hypothetical protein 0.0209 0.0153 0.6376
Trypanosoma brucei polo-like protein kinase 0.0229 0.0169 0.205
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.0038 0.0012 0.0073
Plasmodium vivax hypothetical protein, conserved 0.0209 0.0153 0.6376
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0227 0.0167 0.0482
Schistosoma mansoni 6-phosphofructokinase 0.013 0.0088 0.0664
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0209 0.0153 0.6376
Entamoeba histolytica protein kinase, putative 0.0061 0.0031 0.0249
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0536 0.0421 0.4831
Giardia lamblia Casein kinase II beta chain 0.0044 0.0017 0.0087
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.0061 0.0031 0.0085
Toxoplasma gondii FATC domain-containing protein 0.0571 0.045 0.5601
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0073 0.0041 0.0474
Schistosoma mansoni hypothetical protein 0.0098 0.0061 0.0455
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.0044 0.0017 0.0084
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog 0.0038 0.0012 0.0145
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0315 0.024 0.2782
Loa Loa (eye worm) hypothetical protein 0.0613 0.0484 0.4248
Trichomonas vaginalis CAMK family protein kinase 0.0115 0.0076 0.0877
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0073 0.0041 0.0474
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0384 0.0297 0.26
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0817 0.0651 0.7563
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0482 0.0377 0.456
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0209 0.0153 0.1175
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0482 0.0377 0.4371
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0209 0.0153 0.1774
Mycobacterium ulcerans 6-phosphofructokinase 0.013 0.0088 0.3741
Loa Loa (eye worm) glutaminase 2 0.0309 0.0235 0.2057
Trichomonas vaginalis casein kinase II beta chain, putative 0.0044 0.0017 0.0196
Loa Loa (eye worm) cytochrome P450 family protein 0.0036 0.001 0.0089
Loa Loa (eye worm) phosphatidylinositol 3 0.0272 0.0205 0.1795
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.1029 0.0826 0.6456
Entamoeba histolytica phosphofructokinase, putative 0.013 0.0088 0.0915
Trichomonas vaginalis PIKK family atypical protein kinase 0.1001 0.0803 0.9325
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0209 0.0153 0.1851
Trypanosoma brucei Casein kinase II 0.0164 0.0115 0.1399
Onchocerca volvulus Casein kinase II subunit beta homolog 0.0044 0.0017 0.0022
Trichomonas vaginalis CMGC family protein kinase 0.0164 0.0115 0.134
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0792 0.0631 0.0628
Trichomonas vaginalis CAMK family protein kinase 0.0229 0.0169 0.1965
Trichomonas vaginalis PIKK family atypical protein kinase 0.1007 0.0808 0.9378
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0315 0.024 0.0237
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.0863 0.0689 0.7982
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0073 0.0041 0.0474
Echinococcus granulosus proto oncogene serine:threonine protein kinase 0.0384 0.0297 0.0294
Loa Loa (eye worm) hypothetical protein 0.0407 0.0315 0.2762
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0315 0.024 0.2699
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0315 0.024 0.2984
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.1018 0.0816 0.6384
Trichomonas vaginalis PIKK family atypical protein kinase 0.0979 0.0785 0.9116
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.0032 0.0007 0.0086
Plasmodium falciparum casein kinase 2, alpha subunit 0.0164 0.0115 0.4818
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0038 0.0012 0.0009
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.0032 0.0007 0.0004
Trypanosoma cruzi hypothetical protein, conserved 0.4252 0.3472 1
Trichomonas vaginalis conserved hypothetical protein 0.0073 0.0041 0.0474
Plasmodium falciparum casein kinase II beta chain 0.0044 0.0017 0.0705
Trichomonas vaginalis conserved hypothetical protein 0.0064 0.0034 0.0389
Echinococcus multilocularis voltage dependent calcium channel 0.0038 0.0012 0.0009
Trichomonas vaginalis PIKK family atypical protein kinase 0.0979 0.0785 0.9115
Echinococcus multilocularis 0.0209 0.0153 0.015
Trichomonas vaginalis CMGC family protein kinase 0.0164 0.0115 0.134
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0209 0.0153 0.1774
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0073 0.0041 0.0474
Trichomonas vaginalis PIKK family atypical protein kinase 0.0985 0.079 0.9169
Brugia malayi SH2 domain containing protein 0.0407 0.0315 0.3657
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.0044 0.0017 0.0084
Giardia lamblia Kinase, CMGC GSK 0.0061 0.0031 0.026
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0404 0.0313 0.031
Trichomonas vaginalis CMGC family protein kinase 0.0164 0.0115 0.134
Onchocerca volvulus Casein kinase II subunit beta homolog 0.0044 0.0017 0.0022
Brugia malayi Protein kinase domain containing protein 0.0384 0.0297 0.3443
Trichomonas vaginalis PIKK family atypical protein kinase 0.1001 0.0803 0.9325
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0482 0.0377 0.4307
Trichomonas vaginalis PIKK family atypical protein kinase 0.1001 0.0803 0.9325
Trichomonas vaginalis phosphofructokinase, putative 0.0035 0.001 0.0113
Trichomonas vaginalis PIKK family atypical protein kinase 0.097 0.0778 0.9028
Toxoplasma gondii 6-phosphofructokinase 0.0035 0.001 0.0121
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.1029 0.0826 0.2266
Loa Loa (eye worm) hypoxia-induced factor 1 0.018 0.0129 0.113
Trypanosoma cruzi polo-like protein kinase, putative 0.0229 0.0169 0.0488
Brugia malayi Serine/threonine-protein kinase Pim-3 0.0384 0.0297 0.3443
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0209 0.0153 0.015
Trichomonas vaginalis PIKK family atypical protein kinase 0.0663 0.0525 0.6096
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0613 0.0484 0.6032
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0376 0.029 0.343
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0073 0.0041 0.0495
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.1029 0.0826 0.9583
Mycobacterium ulcerans putative regulatory protein 0.0023 0.0000059662 0.0003
Trichomonas vaginalis CMGC family protein kinase 0.0164 0.0115 0.134
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0229 0.0169 0.0465
Loa Loa (eye worm) glutaminase 0.0309 0.0235 0.2057
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0482 0.0377 0.4371
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0315 0.024 0.2782
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0482 0.0377 0.4372
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0073 0.0041 0.0474
Trichomonas vaginalis CMGC family protein kinase 0.0164 0.0115 0.134
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.1072 0.0861 1
Echinococcus multilocularis 6 phosphofructokinase 0.013 0.0088 0.0085
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0035 0.001 0.5
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0209 0.0153 0.1902
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.1029 0.0826 0.2378
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0073 0.0041 0.0474
Schistosoma mansoni casein kinase II beta subunit 0.0044 0.0017 0.0109
Trichomonas vaginalis PIKK family atypical protein kinase 0.0625 0.0494 0.5737
Plasmodium falciparum casein kinase II beta chain 0.0044 0.0017 0.0705
Trichomonas vaginalis CMGC family protein kinase 0.0061 0.0031 0.036
Brugia malayi serine/threonine-protein kinase plk-2 0.0229 0.0169 0.1965
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0073 0.0041 0.0474
Entamoeba histolytica phosphofructokinase, putative 0.013 0.0088 0.0915
Brugia malayi FAT domain containing protein 0.0404 0.0313 0.3629
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.1072 0.0861 0.2481
Brugia malayi PXA domain containing protein 0.0025 0.0001 0.0014
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0315 0.024 0.2984
Echinococcus granulosus 6 phosphofructokinase 0.013 0.0088 0.0085
Trichomonas vaginalis conserved hypothetical protein 0.0613 0.0484 0.5624
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0035 0.001 0.0121
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0315 0.024 0.0658
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0073 0.0041 0.0474
Trichomonas vaginalis PIKK family atypical protein kinase 0.0209 0.0153 0.1774
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.1029 0.0826 0.9587
Loa Loa (eye worm) hypothetical protein 0.0038 0.0012 0.0109
Mycobacterium ulcerans glutaminase 0.0309 0.0235 1
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.0073 0.0041 0.0297
Trypanosoma brucei Casein kinase II subunit beta, putative 0.0044 0.0017 0.0205
Giardia lamblia Kinase, CMGC GSK 0.0061 0.0031 0.026
Leishmania major hypothetical protein, conserved 0.4461 0.3644 1
Entamoeba histolytica casein kinase, putative 0.0164 0.0115 0.1241
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0315 0.024 0.2102
Plasmodium vivax casein kinase 2, alpha subunit, putative 0.0164 0.0115 0.4818
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0315 0.024 0.1857
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.0032 0.0007 0.0004
Trichomonas vaginalis PIKK family atypical protein kinase 0.0979 0.0785 0.9116
Loa Loa (eye worm) hypothetical protein 0.0362 0.0278 0.2437
Loa Loa (eye worm) 6-phosphofructokinase 0.013 0.0088 0.077
Loa Loa (eye worm) MH2 domain-containing protein 0.0135 0.0092 0.0804
Echinococcus granulosus single minded 2 0.0043 0.0016 0.0013
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0209 0.0153 0.1175
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0315 0.024 1
Schistosoma mansoni kinase 0.0118 0.0078 0.0588
Plasmodium vivax casein kinase II beta chain, putative 0.0044 0.0017 0.0705
Loa Loa (eye worm) phosphatidylinositol 3-kinase catalytic subunit gamma 0.0057 0.0028 0.0244
Echinococcus multilocularis high voltage activated calcium channel beta 0.0104 0.0066 0.0063
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0209 0.0153 0.1902
Loa Loa (eye worm) CMGC/CDK/CDK8 protein kinase 0.016 0.0112 0.0986
Trichomonas vaginalis PIKK family atypical protein kinase 0.0344 0.0264 0.306
Giardia lamblia Kinase, CMGC CK2 0.0164 0.0115 0.1295
Entamoeba histolytica hypothetical protein 0.0043 0.0016 0.0076
Echinococcus granulosus phosphatidylinositol 3 kinase regulatory subunit 0.0104 0.0066 0.0063
Brugia malayi intracellular kinase 0.0061 0.0031 0.036
Leishmania major protein kinase ck2 regulatory subunit, putative 0.0044 0.0017 0.0047
Loa Loa (eye worm) voltage-dependent calcium channel beta 2a subunit 0.0214 0.0157 0.1373
Brugia malayi Serotonin receptor 0.0558 0.0439 0.5099
Echinococcus multilocularis transfer RNA-Lys 0.0043 0.0016 0.0013
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0571 0.045 0.3506
Trichomonas vaginalis CMGC family protein kinase 0.0164 0.0115 0.134
Loa Loa (eye worm) hypothetical protein 0.0283 0.0213 0.187
Loa Loa (eye worm) phosphatidylinositol 3 0.097 0.0778 0.6819
Trichomonas vaginalis casein kinase II beta chain, putative 0.0044 0.0017 0.0196
Trichomonas vaginalis CAMK family protein kinase 0.0229 0.0169 0.1965
Loa Loa (eye worm) hypothetical protein 0.0792 0.0631 0.5534
Entamoeba histolytica serine/threonine protein kinase, putative 0.0229 0.0169 0.1873
Loa Loa (eye worm) Csnk2b protein 0.0044 0.0017 0.0149
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.1579 0.1277 0.1274
Trichomonas vaginalis PIKK family atypical protein kinase 0.0979 0.0785 0.9116
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0384 0.0297 0.26
Schistosoma mansoni hypothetical protein 0.0058 0.0028 0.0198
Trichomonas vaginalis PIKK family atypical protein kinase 0.0231 0.0171 0.1983
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0315 0.024 0.2782
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0073 0.0041 0.0474
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0073 0.0041 0.0474
Trichomonas vaginalis PIKK family atypical protein kinase 0.0603 0.0476 0.5527
Loa Loa (eye worm) hypothetical protein 0.0059 0.003 0.0259
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.013 0.0088 0.574
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.0044 0.0017 0.0084
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0571 0.045 0.5164
Brugia malayi Voltage-dependent L-type calcium channel beta-2 subunit 0.0214 0.0157 0.1818
Brugia malayi Casein kinase II, alpha chain 0.0164 0.0115 0.1341
Leishmania major phosphatidylinositol 3-related kinase, putative 0.097 0.0778 0.2134
Brugia malayi Protein kinase domain containing protein 0.016 0.0112 0.1305
Toxoplasma gondii hypothetical protein 0.0064 0.0034 0.0417
Trypanosoma brucei target of rapamycin kinase 3, putative 0.1007 0.0808 0.9782
Schistosoma mansoni survival motor neuron protein 0.0058 0.0028 0.0198
Echinococcus granulosus high voltage activated calcium channel beta 0.0104 0.0066 0.0063
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0073 0.0041 0.0118
Trypanosoma cruzi Casein kinase II subunit beta, putative 0.0044 0.0017 0.0049
Echinococcus multilocularis tumor protein p63 0.0404 0.0313 0.031
Onchocerca volvulus 0.0061 0.0031 0.0525
Trypanosoma cruzi Casein kinase II subunit beta, putative 0.0044 0.0017 0.0049
Trichomonas vaginalis casein kinase II beta chain, putative 0.0044 0.0017 0.0196
Trichomonas vaginalis phosphofructokinase, putative 0.0035 0.001 0.0113
Trichomonas vaginalis PIKK family atypical protein kinase 0.1001 0.0803 0.9325
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0209 0.0153 0.6376
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0794 0.0633 0.7353
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0073 0.0041 0.0474
Brugia malayi hypoxia-induced factor 1 0.018 0.0129 0.1496
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0571 0.045 0.5223
Echinococcus granulosus protein kinase shaggy 0.0061 0.0031 0.0028
Loa Loa (eye worm) calcium channel 0.0038 0.0012 0.0109
Loa Loa (eye worm) hypothetical protein 0.0209 0.0153 0.134
Plasmodium vivax 6-phosphofructokinase, putative 0.0035 0.001 0.0407
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0272 0.0205 0.0589
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.013 0.0088 1
Trypanosoma cruzi target of rapamycin kinase 3 0.1007 0.0808 0.2326
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.1029 0.0826 0.2378
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0035 0.001 0.0113
Echinococcus multilocularis expressed protein 0.0447 0.0348 0.0345
Schistosoma mansoni fkbp-rapamycin associated protein 0.0554 0.0435 0.3393
Echinococcus granulosus casein kinase ii subunit beta 0.0044 0.0017 0.0014
Brugia malayi hypothetical protein 0.0195 0.0141 0.1641
Trichomonas vaginalis CAMK family protein kinase 0.0229 0.0169 0.1965
Leishmania major phosphatidylinositol 4-kinase, putative 0.0209 0.0153 0.0419
Trichomonas vaginalis PIKK family atypical protein kinase 0.0597 0.0471 0.5474
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0315 0.024 0.2902
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.0061 0.0031 0.0386
Loa Loa (eye worm) gastrulation defective protein 1 0.0156 0.0109 0.0957
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0554 0.0435 0.0432
Loa Loa (eye worm) PXA domain-containing protein 0.0025 0.0001 0.001
Trichomonas vaginalis PIKK family atypical protein kinase 0.1007 0.0808 0.9378
Leishmania major phosphatidylinositol kinase related protein, putative 0.0227 0.0167 0.0459
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0571 0.045 0.1296

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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