TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 538.773 | Formula: C24H14Cl3N7O2
H donors: 2 H acceptors: 5 LogP: 5.8 Rotable bonds: 7
Rule of 5 violations (Lipinski): 2
SMILES: N#Cc1cc(cc(c1)Cl)Oc1cc(OCc2n[nH]c(c2Cl)c2ccc(cc2)c2[nH]nnn2)ccc1Cl
InChi: 1S/C24H14Cl3N7O2/c25-16-7-13(11-28)8-18(9-16)36-21-10-17(5-6-19(21)26)35-12-20-22(27)23(30-29-20)14-1-3-15(4-2-14)24-31-33-34-32-24/h1-10H,12H2,(H,29,30)(H,31,32,33,34)
InChiKey: JWDAEHXXNUMMKQ-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Human immunodeficiency virus 1	Reverse transcriptase	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Schistosoma mansoni	hypothetical protein	Get druggable targets OG5_139608	All targets in OG5_139608
Plasmodium yoelii	integrase-related	Get druggable targets OG5_139608	All targets in OG5_139608
Trypanosoma brucei	RNA helicase, putative	Get druggable targets OG5_139608	All targets in OG5_139608
Trypanosoma congolense	RNA helicase, putative	Get druggable targets OG5_139608	All targets in OG5_139608

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Dictyostelium discoideum	hypothetical protein	Reverse transcriptase	259 aa	222 aa	22.5 %
Echinococcus multilocularis	RNA directed DNA polymerase (reverse transcriptase)	Reverse transcriptase	259 aa	208 aa	26.4 %
Echinococcus multilocularis	RNA directed DNA polymerase (reverse transcriptase)	Reverse transcriptase	259 aa	227 aa	26.4 %
Trypanosoma congolense	Retroviral aspartyl protease/Reverse transcriptase (RNA-dependent DNA polymerase)/RNase H, putative	Reverse transcriptase	259 aa	237 aa	29.1 %
Dictyostelium discoideum	hypothetical protein	Reverse transcriptase	259 aa	226 aa	24.3 %
Candida albicans	ReverseTranscriptase similar to fruit fly Tom element	Reverse transcriptase	259 aa	244 aa	27.9 %
Candida albicans	polyprotein of retrotransposon Tca8	Reverse transcriptase	259 aa	238 aa	26.5 %
Dictyostelium discoideum	hypothetical protein	Reverse transcriptase	259 aa	245 aa	25.7 %
Echinococcus multilocularis	RNA directed DNA polymerase (reverse transcriptase)	Reverse transcriptase	259 aa	227 aa	26.4 %
Candida albicans	hypothetical protein	Reverse transcriptase	259 aa	223 aa	29.1 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	fetal alzheimer antigen, falz	0.0025	0.0294	0.0318
Schistosoma mansoni	cpg binding protein	0.0033	0.0459	0.0465
Trypanosoma brucei	RNA helicase, putative	0.0167	0.3261	0.4124
Entamoeba histolytica	aminopeptidase, putative	0.0382	0.776	1
Leishmania major	hypothetical protein, conserved	0.0076	0.1373	0.1659
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0015	0.0079	0.0053
Schistosoma mansoni	hypothetical protein	0.0175	0.3436	0.4353
Echinococcus granulosus	SAM and MBT domain containing protein	0.0048	0.0784	0.0953
Echinococcus multilocularis	endonuclease exonuclease phosphatase	0.019	0.3759	0.4811
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0784	0.0965
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0097	0.1811	0.2231
Echinococcus multilocularis	aspartyl aminopeptidase	0.0382	0.776	1
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0076	0.1373	0.1659
Brugia malayi	Cytochrome P450 family protein	0.0016	0.0109	0.014
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0097	0.1811	0.2285
Loa Loa (eye worm)	hypothetical protein	0.0018	0.015	0.0145
Mycobacterium tuberculosis	Probable aminopeptidase PepC	0.0382	0.776	0.7404
Echinococcus multilocularis	GPCR, family 2	0.0018	0.015	0.0131
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0061	0.1057	0.4975
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0067	0.1175	0.146
Schistosoma mansoni	hypothetical protein	0.0018	0.015	0.0062
Schistosoma mansoni	bromodomain containing protein	0.0071	0.1252	0.1501
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.0312	0.6303	0.8096
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0046	0.0745	0.0903
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0018	0.015	0.0131
Brugia malayi	Intermediate filament tail domain containing protein	0.0027	0.0346	0.0445
Trichomonas vaginalis	hypothetical protein	0.0179	0.3516	0.395
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0057	0.0967	0.1202
Brugia malayi	beta-lactamase family protein	0.0076	0.1373	0.1769
Trypanosoma brucei	mitochondrial DNA polymerase beta	0.0312	0.6303	0.8096
Echinococcus multilocularis	polycomb protein SCMH1	0.0048	0.0784	0.0953
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0146	0.2818	0.3591
Loa Loa (eye worm)	hypothetical protein	0.004	0.0602	0.073
Echinococcus granulosus	polycomb protein SCMH1	0.0048	0.0784	0.0953
Schistosoma mansoni	myelin transcription factor 1 myt1	0.0055	0.0924	0.1072
Schistosoma mansoni	cpg binding protein	0.0033	0.0459	0.0465
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0154	0.015
Echinococcus multilocularis	muscleblind protein 1	0.0154	0.3002	0.383
Plasmodium falciparum	M18 aspartyl aminopeptidase	0.0382	0.776	1
Trypanosoma cruzi	cytochrome P450, putative	0.0016	0.0109	0.0008
Brugia malayi	CXXC zinc finger family protein	0.0029	0.0383	0.0493
Trichomonas vaginalis	penicillin-binding protein, putative	0.0076	0.1373	0.0895
Onchocerca volvulus		0.0048	0.0784	0.4265
Brugia malayi	mbt repeat family protein	0.0048	0.0784	0.101
Schistosoma mansoni	scm-relatedprotein containing 4 mbt domains (sfmbt)	0.0048	0.0784	0.0889
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0018	0.015	0.0131
Schistosoma mansoni	aspartyl aminopeptidase (M18 family)	0.0382	0.776	1
Loa Loa (eye worm)	PHD-finger family protein	0.0021	0.0218	0.0233
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0053	0.0891	0.1029
Echinococcus multilocularis	muscleblind protein	0.0154	0.3002	0.383
Entamoeba histolytica	aspartyl aminopeptidase, putative	0.0382	0.776	1
Loa Loa (eye worm)	cytochrome P450 family protein	0.0016	0.0109	0.0091
Trypanosoma cruzi	aspartyl aminopeptidase, putative	0.0382	0.776	1
Brugia malayi	Bromodomain containing protein	0.0083	0.1505	0.194
Echinococcus granulosus	histone acetyltransferase MYST2	0.0055	0.0924	0.1135
Brugia malayi	Latrophilin receptor protein 2	0.0018	0.015	0.0193
Trypanosoma brucei	cytochrome P450, putative	0.0016	0.0109	0.0008
Schistosoma mansoni	acetyl-CoA C-acetyltransferase	0.0025	0.0294	0.025
Echinococcus multilocularis	methyl CpG binding domain protein 2	0.0018	0.0141	0.0119
Trypanosoma cruzi	cytochrome P450, putative	0.0016	0.0109	0.0008
Schistosoma mansoni	hypothetical protein	0.0175	0.3436	0.4353
Brugia malayi	Bromodomain containing protein	0.0043	0.0677	0.0872
Loa Loa (eye worm)	bromodomain containing protein	0.0022	0.0231	0.0249
Echinococcus granulosus	geminin	0.0175	0.3436	0.4392
Giardia lamblia	Histone acetyltransferase GCN5	0.004	0.0617	0.5
Loa Loa (eye worm)	aspartyl aminopeptidase	0.0382	0.776	1
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0067	0.1175	0.146
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0076	0.1373	0.1728
Loa Loa (eye worm)	mbt repeat family protein	0.0048	0.0784	0.0965
Schistosoma mansoni	cpg binding protein	0.0029	0.0383	0.0366
Brugia malayi	Cytochrome P450 family protein	0.0016	0.0109	0.014
Plasmodium vivax	hypothetical protein, conserved	0.0076	0.1373	0.0895
Echinococcus multilocularis	lamin	0.0027	0.0346	0.0385
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0018	0.015	0.0145
Loa Loa (eye worm)	hypothetical protein	0.0154	0.3002	0.3838
Trypanosoma cruzi	DNA polymerase beta thumb, putative	0.0044	0.069	0.0767
Trichomonas vaginalis	conserved hypothetical protein	0.0179	0.3516	0.395
Brugia malayi	acetyltransferase, GNAT family protein	0.0152	0.2957	0.3811
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0037	0.0549	0.0649
Trichomonas vaginalis	D-aminoacylase, putative	0.0076	0.1373	0.0895
Trypanosoma brucei	mitochondrial DNA polymerase beta-PAK	0.0148	0.2863	0.3604
Loa Loa (eye worm)	beta-lactamase	0.0076	0.1373	0.1728
Loa Loa (eye worm)	hypothetical protein	0.0382	0.776	1
Echinococcus granulosus	aspartyl aminopeptidase	0.0382	0.776	1
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0076	0.1373	0.1717
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0346	0.0398
Mycobacterium ulcerans	beta-lactamase	0.0076	0.1373	0.4074
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0044	0.069	0.0767
Schistosoma mansoni	hypothetical protein	0.0167	0.3261	0.4124
Loa Loa (eye worm)	hypothetical protein	0.0076	0.1373	0.1728
Schistosoma mansoni	hypothetical protein	0.0294	0.5922	0.76
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.0312	0.6303	0.8096
Trypanosoma cruzi	hypothetical protein, conserved	0.0076	0.1373	0.1659
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0097	0.1811	0.2334
Leishmania major	cytochrome p450-like protein	0.0016	0.0109	0.0008
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0037	0.0549	0.0649
Trichomonas vaginalis	penicillin-binding protein, putative	0.0076	0.1373	0.0895
Loa Loa (eye worm)	hypothetical protein	0.0046	0.073	0.0895
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0589	0.0713
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0097	0.1811	0.2231
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0335	0.0384
Trypanosoma brucei	aspartyl aminopeptidase, putative	0.0382	0.776	1
Loa Loa (eye worm)	cytochrome P450 family protein	0.0016	0.0109	0.0091
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0018	0.015	0.0193
Echinococcus multilocularis	lamin dm0	0.0027	0.0346	0.0385
Onchocerca volvulus		0.0076	0.1373	1
Schistosoma mansoni	lamin	0.0027	0.0346	0.0317
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0967	0.1202
Echinococcus granulosus	GPCR family 2	0.0018	0.015	0.0131
Echinococcus multilocularis	zinc finger protein	0.0026	0.0307	0.0335
Trypanosoma brucei	aspartyl aminopeptidase, putative	0.0382	0.776	1
Echinococcus granulosus	cpg binding protein	0.0033	0.0459	0.0532
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0057	0.0967	0.1246
Onchocerca volvulus		0.0076	0.1373	1
Schistosoma mansoni	sex comb on midleg homolog	0.0048	0.0784	0.0889
Brugia malayi	mbt repeat family protein	0.0048	0.0784	0.101
Echinococcus granulosus	suppression of tumorigenicity 18 protein	0.0055	0.0924	0.1135
Schistosoma mansoni	hypothetical protein	0.0018	0.015	0.0062
Onchocerca volvulus		0.0029	0.0383	0.0363
Loa Loa (eye worm)	hypothetical protein	0.0073	0.1301	0.1635
Echinococcus granulosus	histone lysine methyltransferase setb	0.0018	0.0154	0.0137
Trypanosoma cruzi	hypothetical protein, conserved	0.0076	0.1373	0.1659
Echinococcus multilocularis	musashi	0.0027	0.0346	0.0385
Loa Loa (eye worm)	intermediate filament protein	0.0027	0.0346	0.0398
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0097	0.1811	0.2285
Schistosoma mansoni	gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2	0.0152	0.2957	0.3728
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0148	0.2863	0.3604
Echinococcus granulosus	methyl CpG binding domain protein 2	0.0018	0.0141	0.0119
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0029	0.0383	0.0446
Echinococcus multilocularis	histone acetyltransferase MYST2	0.0055	0.0924	0.1135
Schistosoma mansoni	hypothetical protein	0.0021	0.0218	0.0151
Echinococcus granulosus	fetal alzheimer antigen falz	0.0025	0.0294	0.0318
Loa Loa (eye worm)	hypothetical protein	0.0382	0.776	1
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0062	0.1068	0.126
Brugia malayi	Muscleblind-like protein	0.0154	0.3002	0.3868
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0076	0.1373	0.1769
Leishmania major	aspartyl aminopeptidase, putative,metallo-peptidase, Clan MH, Family M20	0.0382	0.776	1
Schistosoma mansoni	sex comb on midleg homolog	0.0048	0.0784	0.0889
Loa Loa (eye worm)	MBCTL1	0.0055	0.0924	0.1147
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0076	0.1373	0.4074
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0018	0.0154	0.0137
Loa Loa (eye worm)	hypothetical protein	0.0076	0.1373	0.1728
Mycobacterium ulcerans	hypothetical protein	0.0164	0.3212	1
Loa Loa (eye worm)	hypothetical protein	0.0076	0.1373	0.1728
Brugia malayi	Aspartyl aminopeptidase	0.0382	0.776	1
Loa Loa (eye worm)	hypothetical protein	0.0076	0.1373	0.1728
Echinococcus granulosus	zinc finger protein	0.0026	0.0307	0.0335
Schistosoma mansoni	hypothetical protein	0.0039	0.0589	0.0634
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0049	0.0014
Schistosoma mansoni	lamin	0.0027	0.0346	0.0317
Schistosoma mansoni	intermediate filament proteins	0.0027	0.0346	0.0317
Mycobacterium leprae	PROBABLE AMINOPEPTIDASE PEPC	0.0382	0.776	1
Brugia malayi	C2-HC type zinc finger protein C.e-MyT1	0.0055	0.0924	0.119
Echinococcus multilocularis	gcn5proteinral control of amino acid synthesis	0.0152	0.2957	0.3771
Trypanosoma brucei	hypothetical protein, conserved	0.0076	0.1373	0.1659
Trichomonas vaginalis	D-aminoacylase, putative	0.0076	0.1373	0.0895
Loa Loa (eye worm)	hypothetical protein	0.0076	0.1373	0.1728
Toxoplasma gondii	hypothetical protein	0.005	0.0825	0.1281
Plasmodium vivax	M18 aspartyl aminopeptidase, putative	0.0382	0.776	1
Trichomonas vaginalis	conserved hypothetical protein	0.0179	0.3516	0.395
Loa Loa (eye worm)	acetyltransferase	0.0152	0.2957	0.378
Loa Loa (eye worm)	hypothetical protein	0.0154	0.3002	0.3838
Echinococcus multilocularis	SAM and MBT domain containing protein	0.0048	0.0784	0.0953
Leishmania major	mitochondrial DNA polymerase beta	0.0312	0.6303	0.8096
Loa Loa (eye worm)	hypothetical protein	0.0076	0.1373	0.1728
Trichomonas vaginalis	Clan MH, family M18, aspartyl aminopeptidase-like metallopeptidase	0.0382	0.776	1
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0076	0.1373	0.1659
Mycobacterium ulcerans	hypothetical protein	0.0076	0.1373	0.4074
Onchocerca volvulus		0.0076	0.1373	1
Echinococcus multilocularis	geminin	0.0175	0.3436	0.4392
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0924	0.1147
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0018	0.0154	0.0067
Schistosoma mansoni	hypothetical protein	0.0018	0.015	0.0062
Brugia malayi	beta-lactamase	0.0076	0.1373	0.1769
Toxoplasma gondii	ABC1 family protein	0.0076	0.1373	1
Schistosoma mansoni	methyl-cpg binding protein mbd	0.0018	0.0141	0.005
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0018	0.0154	0.0067
Onchocerca volvulus	Polycomb protein Sfmbt homolog	0.0048	0.0784	0.4265
Brugia malayi	PHD-finger family protein	0.0031	0.0422	0.0544
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0097	0.1811	0.2285
Echinococcus granulosus	lamin dm0	0.0027	0.0346	0.0385
Echinococcus granulosus	intermediate filament protein	0.0027	0.0346	0.0385
Echinococcus multilocularis	cpg binding protein	0.0033	0.0459	0.0532
Echinococcus granulosus	endonuclease exonuclease phosphatase	0.019	0.3759	0.4811
Brugia malayi	intermediate filament protein	0.0027	0.0346	0.0445
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0806	0.0994
Brugia malayi	latrophilin 2 splice variant baaae	0.0039	0.0589	0.0759
Mycobacterium ulcerans	esterase/lipase LipP	0.0076	0.1373	0.4074
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0057	0.0967	0.1246
Trichomonas vaginalis	esterase, putative	0.0076	0.1373	0.0895
Schistosoma mansoni	aspartyl aminopeptidase (M18 family)	0.0382	0.776	1
Trichomonas vaginalis	Clan MH, family M18, aspartyl aminopeptidase-like metallopeptidase	0.0179	0.3516	0.395
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0164	0.3212	0.2132
Leishmania major	mitochondrial DNA polymerase beta-PAK, putative	0.0148	0.2863	0.3604
Trypanosoma brucei	DNA polymerase beta thumb, putative	0.0044	0.069	0.0767
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0097	0.1811	0.2296
Loa Loa (eye worm)	CYP4Cod1	0.0016	0.0109	0.0091
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0097	0.1811	0.2285
Brugia malayi	beta-lactamase family protein	0.0076	0.1373	0.1769
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0018	0.015	0.0131
Trichomonas vaginalis	Clan MH, family M18, aspartyl aminopeptidase-like metallopeptidase	0.0179	0.3516	0.395
Echinococcus granulosus	muscleblind protein	0.0154	0.3002	0.383
Trypanosoma cruzi	DNA polymerase beta thumb, putative	0.0044	0.069	0.0767
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0097	0.1811	0.2231
Trypanosoma cruzi	metallo-peptidase, Clan MH, Family M20	0.0382	0.776	1
Trichomonas vaginalis	Clan MH, family M18, aspartyl aminopeptidase-like metallopeptidase	0.0382	0.776	1
Schistosoma mansoni	hypothetical protein	0.0018	0.015	0.0062
Trichomonas vaginalis	Clan MH, family M18, aspartyl aminopeptidase-like metallopeptidase	0.0179	0.3516	0.395
Trichomonas vaginalis	conserved hypothetical protein	0.0179	0.3516	0.395
Echinococcus granulosus	beta LACTamase domain containing family member	0.0076	0.1373	0.1717
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0027	0.0346	0.0398
Echinococcus granulosus	lamin	0.0027	0.0346	0.0385
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0018	0.015	0.0131
Mycobacterium ulcerans	lipase LipD	0.0076	0.1373	0.4074
Brugia malayi	cytoplasmic intermediate filament protein	0.0015	0.0079	0.0102
Trichomonas vaginalis	Clan MH, family M18, aspartyl aminopeptidase-like metallopeptidase	0.0382	0.776	1
Trichomonas vaginalis	D-aminoacylase, putative	0.0076	0.1373	0.0895
Schistosoma mansoni	zinc finger protein	0.0026	0.0307	0.0267
Echinococcus multilocularis	suppression of tumorigenicity 18 protein	0.0055	0.0924	0.1135
Schistosoma mansoni	methyl-cpg binding protein mbd	0.0018	0.0141	0.005

Activities

Activity type	Activity value	Assay description	Source	Reference
Ki (binding)	= 0.3 nM	Inhibition of wild type HIV1 reverse transcriptase by SPA assay	ChEMBL.	20609585

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1801258

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1086247