Detailed information for compound 109642

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 466.526 | Formula: C26H30N2O6
  • H donors: 0 H acceptors: 3 LogP: 5.58 Rotable bonds: 11
    Rule of 5 violations (Lipinski): 1
  • SMILES: COC(=O)C(C(c1ccccc1)(Oc1ccc(cc1)C(C)C)C)Oc1nc(OC)cc(n1)OC
  • InChi: 1S/C26H30N2O6/c1-17(2)18-12-14-20(15-13-18)34-26(3,19-10-8-7-9-11-19)23(24(29)32-6)33-25-27-21(30-4)16-22(28-25)31-5/h7-17,23H,1-6H3
  • InChiKey: GJGNTDZVUULBFL-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens endothelin receptor type B Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus glycine receptor subunit beta 0.0037 0.0555 0.0594
Echinococcus granulosus jun protein 0.0179 0.3376 0.3616
Schistosoma mansoni lipoxygenase 0.002 0.0222 0.0222
Loa Loa (eye worm) beta-lactamase 0.0037 0.0553 0.0842
Schistosoma mansoni nAChR subunit 0.0017 0.0159 0.0159
Schistosoma mansoni hypothetical protein 0.0126 0.2329 0.2329
Echinococcus multilocularis nuclear receptor nhr 48 0.0045 0.0714 0.0765
Loa Loa (eye worm) hypothetical protein 0.002 0.0222 0.0338
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0203 0.301
Mycobacterium leprae Probable lipase LipE 0.0037 0.0553 0.365
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0142 0.0216
Brugia malayi Receptor family ligand binding region containing protein 0.0136 0.2534 0.5005
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0037 0.0555 0.1095
Brugia malayi PXA domain containing protein 0.002 0.0211 0.0416
Brugia malayi hypothetical protein 0.002 0.0222 0.0438
Brugia malayi Acetylcholine receptor protein, alpha-like chain 1 precursor 0.0017 0.0159 0.0314
Trichomonas vaginalis adenylate cyclase, type VII, putative 0.0013 0.0078 0.0505
Toxoplasma gondii rhoptry neck protein RON9 0.0012 0.006 0.0435
Trichomonas vaginalis DNA polymerase eta, putative 0.002 0.0213 0.321
Mycobacterium ulcerans hypothetical protein 0.0037 0.0553 0.3316
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0037 0.0553 0.0943
Echinococcus granulosus C type lectin domian containing protein 0.0012 0.006 0.0064
Brugia malayi metabotropic GABA-B receptor subtype 2 0.0011 0.0047 0.0092
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.002 0.0216 0.0427
Echinococcus multilocularis thyroid hormone receptor alpha 0.0221 0.4224 0.4524
Echinococcus multilocularis netrin receptor unc 5 0.003 0.0414 0.0443
Trypanosoma cruzi DNA polymerase eta, putative 0.002 0.0213 0.3291
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0037 0.0555 0.0555
Mycobacterium leprae conserved hypothetical protein 0.0021 0.0231 0.1174
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0211 0.3158
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0037 0.0555 0.1095
Loa Loa (eye worm) hypothetical protein 0.0037 0.0555 0.0844
Loa Loa (eye worm) hypothetical protein 0.0037 0.0555 0.0844
Brugia malayi Immunoglobulin I-set domain containing protein 0.003 0.0414 0.0817
Loa Loa (eye worm) hypothetical protein 0.0012 0.006 0.0091
Echinococcus multilocularis regulator of G protein signaling 7 0.002 0.0211 0.0226
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0013 0.0078 0.0618
Onchocerca volvulus 0.002 0.0216 0.0511
Loa Loa (eye worm) hypothetical protein 0.0167 0.3142 0.4781
Brugia malayi orphan nuclear receptor NR2E1 0.0045 0.0714 0.1411
Loa Loa (eye worm) hypothetical protein 0.0017 0.0159 0.0242
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0095 0.1715 0.3387
Loa Loa (eye worm) hypothetical protein 0.002 0.0211 0.0321
Schistosoma mansoni hypothetical protein 0.0039 0.0592 0.0592
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.002 0.0211 0.0416
Loa Loa (eye worm) hypothetical protein 0.002 0.0211 0.0321
Mycobacterium ulcerans putative regulatory protein 0.0037 0.0553 0.3316
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0213 0.321
Schistosoma mansoni nuclear receptor 0.0045 0.0714 0.0714
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0203 0.0218
Trichomonas vaginalis DNA helicase recq1, putative 0.0022 0.0255 0.4039
Echinococcus multilocularis axis inhibition protein axin 0.002 0.0211 0.0226
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.002 0.0211 0.0321
Onchocerca volvulus Netrin receptor homolog 0.003 0.0414 0.1107
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0037 0.0555 0.0844
Brugia malayi metabotropic glutamate receptor type 2 0.0031 0.0437 0.0863
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.002 0.0211 0.0321
Echinococcus granulosus metabotropic glutamate receptor 2 0.0011 0.0047 0.005
Echinococcus multilocularis nicotinic acetylcholine receptor subunit type 0.0017 0.0159 0.0171
Brugia malayi nuclear hormone receptor family member odr-7 0.0045 0.0714 0.1411
Entamoeba histolytica recQ family helicase, putative 0.0012 0.0053 0.011
Echinococcus granulosus regulator of G protein signaling 3 0.002 0.0211 0.0226
Schistosoma mansoni nuclear receptor 0.0045 0.0714 0.0714
Echinococcus granulosus ecdysone induced protein 78C 0.0095 0.1715 0.1837
Schistosoma mansoni tar DNA-binding protein 0.0065 0.111 0.111
Plasmodium falciparum apical sushi protein 0.0012 0.006 0.0435
Onchocerca volvulus 0.0037 0.0555 0.1532
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0037 0.0553 0.0943
Brugia malayi nuclear receptor NHR-88 0.0095 0.1715 0.3387
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0095 0.1715 0.1715
Plasmodium falciparum LCCL domain-containing protein 0.002 0.0222 0.1608
Schistosoma mansoni thyroid hormone receptor 0.0221 0.4224 0.4224
Loa Loa (eye worm) hypothetical protein 0.0037 0.0553 0.0842
Schistosoma mansoni tar DNA-binding protein 0.0065 0.111 0.111
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0037 0.0555 0.0594
Schistosoma mansoni axis inhibition protein axin 0.002 0.0211 0.0211
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0037 0.0555 0.0844
Onchocerca volvulus 0.0012 0.006 0.004
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0211 0.3158
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0095 0.1715 0.1715
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0095 0.1715 0.1715
Brugia malayi Protein kinase domain containing protein 0.003 0.0414 0.0817
Brugia malayi hypothetical protein 0.0012 0.006 0.0119
Loa Loa (eye worm) hypothetical protein 0.0011 0.0047 0.0071
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0062 0.106 0.106
Schistosoma mansoni hypothetical protein 0.0016 0.0142 0.0142
Mycobacterium tuberculosis Conserved hypothetical protein 0.002 0.0213 0.0163
Loa Loa (eye worm) hypothetical protein 0.0078 0.1381 0.2101
Echinococcus multilocularis tar DNA binding protein 0.0065 0.111 0.1189
Onchocerca volvulus 0.0012 0.006 0.004
Brugia malayi hypothetical protein 0.0012 0.006 0.0119
Brugia malayi nuclear receptor RXR 0.005 0.0821 0.1622
Loa Loa (eye worm) hypothetical protein 0.0095 0.1715 0.261
Brugia malayi hypothetical protein 0.0045 0.0714 0.1411
Giardia lamblia DINP protein human, muc B family 0.002 0.0213 1
Loa Loa (eye worm) ShTK domain-containing protein 0.0178 0.3361 0.5115
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0222 0.0238
Loa Loa (eye worm) nuclear receptor NHR-67 0.0045 0.0714 0.1087
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.002 0.0211 0.0211
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0078 0.0505
Brugia malayi ShTK domain containing protein 0.0178 0.3361 0.6639
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0142 0.1885
Brugia malayi latrophilin 2 splice variant baaae 0.0035 0.0514 0.1016
Trypanosoma brucei unspecified product 0.002 0.0213 0.321
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0142 0.0152
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0013 0.0078 0.0505
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0126 0.2329 0.2495
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.005 0.0821 0.088
Echinococcus granulosus thyroid hormone receptor alpha 0.0045 0.0714 0.0765
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0553 1
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0213 0.321
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.002 0.0211 0.0321
Schistosoma mansoni metabotropic glutamate receptor 2 3 (mglur group 2) 0.002 0.0211 0.0211
Onchocerca volvulus 0.0178 0.3361 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0095 0.1715 0.1837
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0095 0.1715 0.3387
Schistosoma mansoni nuclear hormone receptor 0.0045 0.0714 0.0714
Brugia malayi Nuclear hormone receptor-like 1 0.0095 0.1715 0.3387
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0095 0.1715 0.1837
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0037 0.0555 0.0594
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0013 0.0078 0.0618
Brugia malayi hypothetical protein 0.0012 0.006 0.0119
Onchocerca volvulus 0.0012 0.006 0.004
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0037 0.0555 0.1095
Schistosoma mansoni regulator of G protein signaling 0.002 0.0211 0.0211
Loa Loa (eye worm) hypothetical protein 0.0095 0.1715 0.261
Brugia malayi hypothetical protein 0.0012 0.006 0.0119
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0011 0.0047 0.005
Mycobacterium tuberculosis Conserved protein 0.0037 0.0553 0.0943
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0213 0.321
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0222 0.0238
Echinococcus granulosus death domain containing protein 0.003 0.0414 0.0443
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0211 0.3158
Onchocerca volvulus 0.014 0.2613 0.7741
Loa Loa (eye worm) hypothetical protein 0.0011 0.0047 0.0071
Loa Loa (eye worm) hypothetical protein 0.0011 0.0047 0.0071
Mycobacterium tuberculosis Probable endonuclease IV End (endodeoxyribonuclease IV) (apurinase) 0.0078 0.1381 0.284
Loa Loa (eye worm) hypothetical protein 0.0037 0.0555 0.0844
Schistosoma mansoni DNA polymerase eta 0.002 0.0213 0.0213
Loa Loa (eye worm) doublecortin family protein 0.002 0.0222 0.0338
Brugia malayi Death domain containing protein 0.003 0.0414 0.0817
Trypanosoma brucei hypothetical protein, conserved 0.0037 0.0553 1
Echinococcus granulosus single minded 2 0.0037 0.0553 0.0593
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0045 0.0714 0.2014
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0095 0.1715 0.3387
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0039 0.0592 0.0635
Loa Loa (eye worm) acetylcholine receptor protein 0.0017 0.0159 0.0242
Loa Loa (eye worm) glutamate receptor 0.0031 0.0437 0.0665
Schistosoma mansoni glutamate receptor NMDA 0.0011 0.0047 0.0047
Loa Loa (eye worm) hypothetical protein 0.0037 0.0553 0.0842
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0037 0.0555 0.0594
Leishmania major protein kinase, putative 0.0013 0.0078 0.0618
Loa Loa (eye worm) CYP4Cod1 0.0016 0.0143 0.0218
Loa Loa (eye worm) cytochrome P450 family protein 0.0016 0.0143 0.0218
Schistosoma mansoni neurotransmitter gated ion channel 0.002 0.0216 0.0216
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0037 0.0555 0.0594
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0213 0.3291
Loa Loa (eye worm) hypothetical protein 0.0045 0.0714 0.1087
Schistosoma mansoni ap endonuclease 0.0019 0.0203 0.0203
Onchocerca volvulus 0.0037 0.0555 0.1532
Loa Loa (eye worm) hypothetical protein 0.002 0.0216 0.0329
Schistosoma mansoni netrin receptor unc5 0.003 0.0414 0.0414
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0056 0.0944 0.1011
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0095 0.1715 0.261
Mycobacterium tuberculosis Probable lipase LipD 0.0037 0.0553 0.0943
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0.0142 0.0142
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0037 0.0555 0.0594
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0213 0.321
Schistosoma mansoni nAChR subunit 0.0037 0.0555 0.0555
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0203 0.014
Mycobacterium tuberculosis Probable hydrolase 0.0037 0.0553 0.0943
Schistosoma mansoni nuclear hormone receptor 0.0095 0.1715 0.1715
Schistosoma mansoni loxhd1 0.002 0.0222 0.0222
Onchocerca volvulus 0.0017 0.0159 0.0339
Trichomonas vaginalis guanylate cyclase, putative 0.0013 0.0078 0.0505
Echinococcus multilocularis GPCR, family 3, C terminal 0.002 0.0211 0.0226
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0095 0.1715 0.1837
Entamoeba histolytica hypothetical protein 0.0039 0.0592 1
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0197 0.374 0.7387
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0045 0.0714 0.2014
Toxoplasma gondii exonuclease III APE 0.0019 0.0203 0.1474
Brugia malayi bHLH-PAS transcription factor 0.0037 0.0553 0.1093
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0203 0.3093
Echinococcus multilocularis tyrosine kinase 0.0011 0.0047 0.005
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0037 0.0553 0.3316
Brugia malayi Metabotropic glutamate receptor precursor. 0.0031 0.0437 0.0863
Loa Loa (eye worm) hypothetical protein 0.0037 0.0553 0.0842
Loa Loa (eye worm) hypothetical protein 0.0037 0.0555 0.0844
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0011 0.0047 0.005
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0037 0.0555 0.0594
Loa Loa (eye worm) hypothetical protein 0.002 0.0211 0.0321
Schistosoma mansoni regulator of G protein signaling 0.002 0.0211 0.0211
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0037 0.0555 0.0844
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0016 0.0142 0.0152
Onchocerca volvulus 0.0178 0.3361 1
Brugia malayi RNA recognition motif domain containing protein 0.0065 0.111 0.2192
Echinococcus granulosus FTZ F1 alpha 0.0095 0.1715 0.1837
Loa Loa (eye worm) hypothetical protein 0.002 0.0216 0.0329
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0037 0.0555 0.0594
Loa Loa (eye worm) hypothetical protein 0.0095 0.1715 0.261
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.002 0.0216 0.0427
Loa Loa (eye worm) hypothetical protein 0.0011 0.0047 0.0071
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0037 0.0553 0.0842
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0203 0.2872
Loa Loa (eye worm) hypothetical protein 0.0037 0.0555 0.0844
Schistosoma mansoni RAR-like nuclear receptor 0.0095 0.1715 0.1715
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0203 0.301
Echinococcus multilocularis C type lectin domian containing protein 0.0012 0.006 0.0064
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0222 0.0238
Entamoeba histolytica hypothetical protein 0.0039 0.0592 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0095 0.1715 0.1837
Echinococcus granulosus netrin receptor unc 5 0.003 0.0414 0.0443
Brugia malayi hypothetical protein 0.0017 0.0159 0.0314
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0037 0.0555 0.0844
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0092 0.0776
Brugia malayi Cytochrome P450 family protein 0.0027 0.0353 0.0697
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0203 0.1086
Mycobacterium tuberculosis Conserved protein 0.0037 0.0553 0.0943
Brugia malayi Hypothetical 29.7 kDa protein C05D11.5 in chromosome III 0.0021 0.0231 0.0456
Loa Loa (eye worm) LGC-31 protein 0.0037 0.0555 0.0844
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0045 0.0714 0.1411
Leishmania major hypothetical protein, conserved 0.0037 0.0553 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.0553 0.0842
Loa Loa (eye worm) hypothetical protein 0.002 0.0211 0.0321
Schistosoma mansoni aryl hydrocarbon receptor 0.005 0.0811 0.0811
Echinococcus multilocularis tumor protein p63 0.0345 0.6697 0.7173
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0213 0.3291
Schistosoma mansoni tyrosine kinase 0.0011 0.0047 0.0047
Entamoeba histolytica hypothetical protein 0.002 0.0211 0.3007
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0017 0.0159 0.0242
Echinococcus granulosus glutamate receptor 2 0.0011 0.0047 0.005
Brugia malayi Regulator of G protein signaling domain containing protein 0.002 0.0211 0.0416
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0126 0.2329 0.2495
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0016 0.0142 0.103
Echinococcus multilocularis neuropeptide receptor A26 0.0478 0.9337 1
Mycobacterium ulcerans epimerase 0.0021 0.0231 0.071
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0095 0.1715 0.1837
Leishmania major cytochrome p450-like protein 0.0016 0.0143 0.1901
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0211 0.3158
Onchocerca volvulus 0.0037 0.0555 0.1532
Loa Loa (eye worm) hypothetical protein 0.0037 0.0555 0.0844
Loa Loa (eye worm) hypothetical protein 0.0012 0.006 0.0091
Brugia malayi hypothetical protein 0.0167 0.3142 0.6206
Schistosoma mansoni acetylcholine receptor-related 0.0017 0.0159 0.0159
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0095 0.1715 0.1837
Mycobacterium tuberculosis Probable lipase LipE 0.0037 0.0553 0.0943
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0045 0.0714 0.0765
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.0011 0.0047 0.005
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0037 0.0555 0.1095
Mycobacterium ulcerans hypothetical protein 0.0021 0.0231 0.071
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0213 0.321
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0142 0.103
Brugia malayi Steroid receptor seven-up type 2 0.0095 0.1715 0.3387
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.003 0.0414 0.0443
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0213 0.0569
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.002 0.0216 0.0427
Brugia malayi isocitrate dehydrogenase 0.0016 0.0142 0.0281
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0213 0.321
Mycobacterium ulcerans lipase LipD 0.0037 0.0553 0.3316
Onchocerca volvulus Protein ultraspiracle homolog 0.0095 0.1715 0.5033
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0037 0.0555 0.0555
Mycobacterium ulcerans beta-lactamase 0.0037 0.0553 0.3316
Loa Loa (eye worm) hypothetical protein 0.0095 0.1715 0.261
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0142 0.0152
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0017 0.0159 0.0314
Loa Loa (eye worm) hypothetical protein 0.0197 0.374 0.5691
Entamoeba histolytica hypothetical protein 0.002 0.0211 0.3007
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0037 0.0555 0.0594
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0017 0.0159 0.0171
Entamoeba histolytica hypothetical protein 0.002 0.0211 0.3007
Brugia malayi excitatory GABA receptor EXP-1A 0.0037 0.0555 0.1095
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0095 0.1715 0.3387
Loa Loa (eye worm) hypothetical protein 0.0037 0.0553 0.0842
Echinococcus multilocularis regulator of G protein signaling 7 0.002 0.0211 0.0226
Echinococcus granulosus nuclear receptor nhr 48 0.0045 0.0714 0.0765
Schistosoma mansoni serine/threonine protein kinase 0.002 0.0211 0.0211
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0013 0.0078 0.0618
Brugia malayi photoreceptor-specific nuclear receptor 0.0095 0.1715 0.3387
Echinococcus multilocularis nAChR subunit 0.002 0.0216 0.0231
Onchocerca volvulus Bile acid receptor homolog 0.0095 0.1715 0.5033
Schistosoma mansoni tyrosinase precursor 0.0511 1 1
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0095 0.1715 0.1837
Loa Loa (eye worm) hypothetical protein 0.0045 0.0714 0.1087
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0553 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0095 0.1715 0.3387
Schistosoma mansoni cpg binding protein 0.0029 0.0405 0.0405
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0095 0.1715 0.1837
Echinococcus multilocularis c4b binding protein beta chain 0.0012 0.006 0.0064
Echinococcus granulosus aryl hydrocarbon receptor 0.0013 0.0078 0.0084
Brugia malayi Receptor family ligand binding region containing protein 0.0011 0.0047 0.0092
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0142 0.0152
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0211 0.3158
Loa Loa (eye worm) hypothetical protein 0.0178 0.3361 0.5115
Schistosoma mansoni regulator of G protein signaling 0.002 0.0211 0.0211
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0095 0.1715 0.261
Onchocerca volvulus 0.002 0.0216 0.0511
Schistosoma mansoni nAChR subunit 0.0037 0.0555 0.0555
Loa Loa (eye worm) hypothetical protein 0.002 0.0216 0.0329
Echinococcus granulosus bloom syndrome protein 0.0022 0.0255 0.0273
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0142 0.1788
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0037 0.0555 0.0555
Trypanosoma cruzi cytochrome P450, putative 0.0016 0.0143 0.1901
Loa Loa (eye worm) metabotropic GABA-B receptor subtype 2 0.0275 0.5289 0.8048
Loa Loa (eye worm) RGC/RGC protein kinase 0.0011 0.0047 0.0071
Brugia malayi hypothetical protein 0.0012 0.006 0.0119
Loa Loa (eye worm) hypothetical protein 0.0017 0.0159 0.0242
Brugia malayi hypothetical protein 0.0045 0.0714 0.1411
Loa Loa (eye worm) tyrosinase 1 0.0178 0.3361 0.5115
Schistosoma mansoni hypothetical protein 0.0173 0.3269 0.3269
Schistosoma mansoni rab6-interacting 0.002 0.0222 0.0222
Toxoplasma gondii rhoptry neck protein RON1 0.0012 0.006 0.0435
Brugia malayi metabotropic glutamate receptor subtype 5a (mGluR5a), putative 0.002 0.0211 0.0416
Onchocerca volvulus 0.0051 0.0827 0.2355
Brugia malayi steroid hormone receptor 0.0095 0.1715 0.3387
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0015 0.0114 0.0411
Loa Loa (eye worm) GABA receptor subunit 0.002 0.0216 0.0329
Loa Loa (eye worm) hypothetical protein 0.002 0.0216 0.0329
Echinococcus granulosus regulator of G protein signaling 7 0.002 0.0211 0.0226
Trypanosoma brucei DNA polymerase eta, putative 0.002 0.0213 0.321
Loa Loa (eye worm) hypothetical protein 0.002 0.0216 0.0329
Loa Loa (eye worm) hypothetical protein 0.0339 0.6572 1
Brugia malayi nuclear hormone receptor family member nhr-6 0.0045 0.0714 0.1411
Schistosoma mansoni cellular tumor antigen P53 0.0051 0.0827 0.0827
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0095 0.1715 0.3387
Schistosoma mansoni jun-related protein 0.0145 0.271 0.271
Echinococcus multilocularis aryl hydrocarbon receptor 0.0013 0.0078 0.0084
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0203 0.9531
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0213 0.321
Loa Loa (eye worm) hypothetical protein 0.018 0.3402 0.5176
Schistosoma mansoni thyroid hormone receptor 0.0221 0.4224 0.4224
Loa Loa (eye worm) pregnancy-associated plasma protein-E 0.0012 0.006 0.0091
Entamoeba histolytica hypothetical protein 0.002 0.0216 0.3103
Echinococcus granulosus receptor type guanylyl cyclase 0.0011 0.0047 0.005
Brugia malayi beta-lactamase family protein 0.0037 0.0553 0.1093
Loa Loa (eye worm) hypothetical protein 0.005 0.0821 0.125
Brugia malayi Cation transporter family protein 0.0037 0.0555 0.1095
Loa Loa (eye worm) hypothetical protein 0.0174 0.3279 0.4989
Echinococcus multilocularis regulator of G protein signaling 3 0.002 0.0211 0.0226
Schistosoma mansoni lipoxygenase 0.0056 0.0944 0.0944
Brugia malayi ecdysteroid receptor 0.0095 0.1715 0.3387
Echinococcus granulosus tar DNA binding protein 0.0065 0.111 0.1189
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0037 0.0555 0.0594
Toxoplasma gondii endonuclease IV APN 0.0078 0.1381 1
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0037 0.0555 0.0555
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0037 0.0555 0.1095
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0213 0.3291
Mycobacterium ulcerans esterase/lipase LipP 0.0037 0.0553 0.3316
Echinococcus granulosus tumor protein p63 0.0345 0.6697 0.7173
Brugia malayi bZIP transcription factor family protein 0.0179 0.3376 0.6668
Schistosoma mansoni polycystin 1-related 0.002 0.0222 0.0222
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0037 0.0555 0.1095
Echinococcus multilocularis receptor type guanylyl cyclase 0.0011 0.0047 0.005
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0037 0.0555 0.0594
Schistosoma mansoni protein kinase 0.0011 0.0047 0.0047
Loa Loa (eye worm) ACC-1 protein 0.0037 0.0555 0.0844
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0045 0.0714 0.0765
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0203 0.1474
Schistosoma mansoni zinc finger protein 0.0045 0.0714 0.0714
Brugia malayi nuclear receptor NHR-67 0.0045 0.0714 0.1411
Onchocerca volvulus 0.0012 0.006 0.004
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0017 0.0159 0.0314
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0222 0.0238
Echinococcus multilocularis isocitrate dehydrogenase 0.0016 0.0142 0.0152
Brugia malayi Bloom's syndrome protein homolog 0.0022 0.0255 0.0504
Loa Loa (eye worm) RNA binding protein 0.0065 0.111 0.1689
Brugia malayi Hypothetical tyrosinase-like protein C02C2.1 in chromosome III 0.0178 0.3361 0.6639
Loa Loa (eye worm) hypothetical protein 0.0035 0.0514 0.0782
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.0013 0.0078 0.0505
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0037 0.0555 0.0844
Echinococcus granulosus regulator of G protein signaling 3 0.002 0.0211 0.0226
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.005 0.0821 0.125
Echinococcus multilocularis transfer RNA-Lys 0.0037 0.0553 0.0593
Loa Loa (eye worm) hypothetical protein 0.0037 0.0555 0.0844
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0039 0.0592 0.0635
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0037 0.0555 0.1095
Schistosoma mansoni tar DNA-binding protein 0.0065 0.111 0.111
Loa Loa (eye worm) RGC/RGC protein kinase 0.0011 0.0047 0.0071
Schistosoma mansoni hypothetical protein 0.0016 0.0142 0.0142
Brugia malayi hypothetical protein 0.0012 0.006 0.0119
Schistosoma mansoni nicotinic acetylcholine receptor alpha 0.002 0.0216 0.0216
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0095 0.1715 0.261
Echinococcus granulosus Regulator of G protein signaling 20 0.002 0.0211 0.0226
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0095 0.1715 0.1715
Brugia malayi beta-lactamase family protein 0.0037 0.0553 0.1093
Echinococcus granulosus GPCR family 2 0.0016 0.0142 0.0152
Onchocerca volvulus 0.0017 0.0159 0.0339
Loa Loa (eye worm) hypothetical protein 0.002 0.0216 0.0329
Brugia malayi Isocitrate dehydrogenase 0.0016 0.0142 0.0281
Loa Loa (eye worm) PXA domain-containing protein 0.002 0.0211 0.0321
Brugia malayi hypothetical protein 0.002 0.0211 0.0416
Loa Loa (eye worm) RGC/RGC protein kinase 0.0011 0.0047 0.0071
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0553 0.0553
Schistosoma mansoni blooms syndrome DNA helicase 0.0017 0.0164 0.0164
Brugia malayi hypothetical protein 0.005 0.0821 0.1622
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0142 0.0152
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0045 0.0714 0.0765
Echinococcus multilocularis Ankyrin 0.003 0.0419 0.0448
Mycobacterium tuberculosis Probable esterase LipL 0.0037 0.0553 0.0943
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0045 0.0714 0.0765
Onchocerca volvulus 0.0095 0.1715 0.5033
Echinococcus multilocularis glycine receptor subunit beta 0.0037 0.0555 0.0594
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.003 0.0419 0.0419
Entamoeba histolytica hypothetical protein 0.0039 0.0592 1
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0213 0.321
Loa Loa (eye worm) hypothetical protein 0.0045 0.0714 0.1087
Loa Loa (eye worm) hypothetical protein 0.0095 0.1715 0.261
Onchocerca volvulus 0.0178 0.3361 1
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.005 0.0821 0.088
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0142 0.0152
Echinococcus multilocularis axis inhibition protein axin 0.002 0.0211 0.0226
Loa Loa (eye worm) hypothetical protein 0.0045 0.0714 0.1087
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0142 0.103
Echinococcus multilocularis cpg binding protein 0.0031 0.0439 0.047
Brugia malayi hypothetical protein 0.005 0.0821 0.1622
Echinococcus multilocularis regulator of G protein signaling 3 0.002 0.0211 0.0226
Onchocerca volvulus 0.0045 0.0714 0.2014
Loa Loa (eye worm) hypothetical protein 0.0095 0.1715 0.261
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0142 0.0152
Loa Loa (eye worm) hypothetical protein 0.0017 0.0159 0.0242
Loa Loa (eye worm) hypothetical protein 0.002 0.0222 0.0338
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0037 0.0555 0.0594
Brugia malayi ecdysone receptor 0.0045 0.0714 0.1411
Loa Loa (eye worm) hypoxia-induced factor 1 0.0154 0.2885 0.4389
Schistosoma mansoni rab6-interacting 0.002 0.0222 0.0222
Echinococcus granulosus dna polymerase eta 0.002 0.0213 0.0229
Schistosoma mansoni nAChR subunit 0.0037 0.0555 0.0555
Loa Loa (eye worm) hypothetical protein 0.0037 0.0555 0.0844
Echinococcus multilocularis bloom syndrome protein 0.0022 0.0255 0.0273
Schistosoma mansoni cpg binding protein 0.0031 0.0439 0.0439
Echinococcus multilocularis metabotropic glutamate receptor 5 0.0031 0.0437 0.0468
Onchocerca volvulus Poor gastrulation protein homolog 0.002 0.0211 0.0495
Echinococcus multilocularis GPCR, family 2 0.0016 0.0142 0.0152
Echinococcus granulosus dnaJ subfamily B 0.0418 0.8145 0.8723
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0203 0.0488
Loa Loa (eye worm) hypothetical protein 0.0017 0.0159 0.0242
Schistosoma mansoni nAChR subunit 0.0037 0.0555 0.0555
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0013 0.0078 0.0618
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.002 0.0216 0.0427
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0037 0.0555 0.0594
Echinococcus multilocularis dna polymerase kappa 0.002 0.0213 0.0229
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0012 0.0053 0.0118
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0013 0.0078 0.0618
Onchocerca volvulus 0.0012 0.006 0.004
Loa Loa (eye worm) hypothetical protein 0.0037 0.0555 0.0844
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0095 0.1715 0.1837
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0142 0.028
Brugia malayi hypothetical protein 0.002 0.0211 0.0416
Schistosoma mansoni neurotransmitter gated ion channel 0.0017 0.0159 0.0159
Mycobacterium leprae conserved hypothetical protein 0.0037 0.0553 0.365
Schistosoma mansoni retinoic acid receptor RXR 0.0095 0.1715 0.1715
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.002 0.0213 0.0229
Echinococcus granulosus Nuclear hormone receptor HR96 0.0045 0.0714 0.0765
Leishmania major DNA polymerase eta, putative 0.002 0.0213 0.3291
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0095 0.1715 0.1837
Brugia malayi Hypothetical tyrosinase-like protein C02C2.1 in chromosome III 0.0178 0.3361 0.6639
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.002 0.0213 0.0229
Schistosoma mansoni hypothetical protein 0.0145 0.271 0.271
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0092 0.0776
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0235 0.4502 1
Echinococcus granulosus neuropeptide receptor A26 0.0478 0.9337 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0047 0.0071
Brugia malayi nuclear receptor RXR 0.0045 0.0714 0.1411
Echinococcus granulosus cpg binding protein 0.0031 0.0439 0.047
Trypanosoma brucei unspecified product 0.0014 0.0092 0.0776
Loa Loa (eye worm) hypothetical protein 0.0017 0.0159 0.0242
Brugia malayi TAR-binding protein 0.0065 0.111 0.2192
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0142 0.028
Echinococcus granulosus Nuclear hormone receptor HR96 0.0045 0.0714 0.0765
Loa Loa (eye worm) receptor family ligand binding region containing protein 0.0136 0.2534 0.3856
Brugia malayi Cation transporter family protein 0.0037 0.0555 0.1095
Loa Loa (eye worm) hypothetical protein 0.0013 0.0078 0.0119
Loa Loa (eye worm) DR-78 0.0045 0.0714 0.1087
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0553 1
Schistosoma mansoni nAChR subunit 0.0037 0.0555 0.0555
Brugia malayi hypothetical protein 0.0011 0.0047 0.0092
Brugia malayi PAS domain containing protein 0.005 0.0811 0.1601
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0095 0.1715 0.1837
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0213 0.321
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0002 0.0002
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0095 0.1715 0.3387
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0045 0.0714 0.0714
Echinococcus granulosus neuropeptide s receptor 0.0478 0.9337 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0213 0.3291
Loa Loa (eye worm) hypothetical protein 0.0037 0.0555 0.0844
Brugia malayi Nuclear hormone receptor E75 0.0045 0.0714 0.1411
Loa Loa (eye worm) hypothetical protein 0.0178 0.3361 0.5115
Onchocerca volvulus Putative nachr subunit 0.0037 0.0555 0.1532
Brugia malayi nuclear receptor NHR-88 0.0045 0.0714 0.1411
Loa Loa (eye worm) hypothetical protein 0.0037 0.0553 0.0842
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0037 0.0555 0.0555
Brugia malayi DNA-(Apurinic or apyrimidinic site) lyase 0.0078 0.1381 0.2727
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.002 0.0213 0.321
Brugia malayi Doublecortin family protein 0.002 0.0222 0.0438
Loa Loa (eye worm) hypothetical protein 0.0016 0.0142 0.0216
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0017 0.0159 0.0314
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.002 0.0213 0.0213
Loa Loa (eye worm) hypothetical protein 0.0017 0.0159 0.0242
Loa Loa (eye worm) hypothetical protein 0.0045 0.0714 0.1087
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0037 0.0555 0.0555
Schistosoma mansoni nuclear hormone receptor 0.0045 0.0714 0.0714
Loa Loa (eye worm) hypothetical protein 0.002 0.0211 0.0321
Schistosoma mansoni transcription factor LCR-F1 0.0039 0.0592 0.0592
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0078 0.0505
Echinococcus multilocularis glutamate receptor 2 0.0011 0.0047 0.005
Schistosoma mansoni acetylcholine receptor subunit beta 0.0017 0.0159 0.0159
Mycobacterium tuberculosis Conserved hypothetical protein 0.0021 0.0231 0.0203
Brugia malayi tailless protein 0.0045 0.0714 0.1411
Loa Loa (eye worm) hypothetical protein 0.0021 0.0231 0.0351
Schistosoma mansoni nAChR subunit 0.0037 0.0555 0.0555
Loa Loa (eye worm) hypothetical protein 0.0011 0.0047 0.0071
Echinococcus granulosus Aryl hydrocarbon receptor nuclear 0.0013 0.0078 0.0084
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0.0142 0.0216
Trypanosoma cruzi cytochrome P450, putative 0.0016 0.0143 0.1901
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0095 0.1715 0.261
Echinococcus granulosus Ankyrin 0.003 0.0419 0.0448
Echinococcus multilocularis nAChR subunit 0.0037 0.0555 0.0594
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0213 0.0569
Echinococcus granulosus glutamate receptor 2 0.0011 0.0047 0.005
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0213 0.321
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0012 0.0053 0.0118
Mycobacterium ulcerans sugar phosphate isomerases/epimerases 0.0021 0.0231 0.071
Loa Loa (eye worm) hypothetical protein 0.0017 0.0159 0.0242
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0095 0.1715 0.5033
Loa Loa (eye worm) hypothetical protein 0.0012 0.006 0.0091
Mycobacterium ulcerans endonuclease IV 0.0078 0.1381 1
Echinococcus granulosus glycine receptor subunit alpha 1 0.0037 0.0555 0.0594
Loa Loa (eye worm) ShTK domain-containing protein 0.0178 0.3361 0.5115
Echinococcus granulosus beta-adrenergic receptor kinase 0.002 0.0211 0.0226
Schistosoma mansoni metabotropic glutamate receptor 0.0031 0.0437 0.0437
Brugia malayi Nuclear hormone receptor E75 0.0045 0.0714 0.1411
Loa Loa (eye worm) steroid hormone receptor 0.0095 0.1715 0.261
Schistosoma mansoni serine/threonine protein kinase 0.002 0.0211 0.0211
Echinococcus multilocularis Aryl hydrocarbon receptor nuclear 0.0013 0.0078 0.0084
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0037 0.0555 0.1095
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0011 0.0047 0.005
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0037 0.0555 0.1095
Schistosoma mansoni hypothetical protein 0.0016 0.0142 0.0142
Loa Loa (eye worm) hypothetical protein 0.0012 0.006 0.0091
Schistosoma mansoni coup transcription factor 0.0095 0.1715 0.1715
Onchocerca volvulus 0.0037 0.0553 0.1529
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0203 0.301
Onchocerca volvulus Metabotropic glutamate receptor homolog 0.002 0.0211 0.0495
Brugia malayi beta-lactamase 0.0037 0.0553 0.1093
Loa Loa (eye worm) hypothetical protein 0.0017 0.0159 0.0242
Loa Loa (eye worm) RecQ helicase 0.0022 0.0255 0.0388
Echinococcus multilocularis FTZ F1 alpha 0.0095 0.1715 0.1837
Toxoplasma gondii histone lysine methyltransferase SET1 0.0056 0.0928 0.6722
Schistosoma mansoni cpg binding protein 0.0031 0.0439 0.0439
Echinococcus granulosus expressed protein 0.0381 0.7417 0.7944
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0016 0.0142 0.1788
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0095 0.1715 0.3387
Schistosoma mansoni nAChR subunit 0.0017 0.0159 0.0159
Onchocerca volvulus 0.0037 0.0555 0.1532
Mycobacterium leprae PROBABLE ENDONUCLEASE IV END (ENDODEOXYRIBONUCLEASE IV) (APURINASE) 0.0078 0.1381 1
Echinococcus granulosus axis inhibition protein axin 0.002 0.0211 0.0226
Schistosoma mansoni hypothetical protein 0.0016 0.0142 0.0142
Echinococcus multilocularis dnaJ subfamily B 0.0418 0.8145 0.8723
Loa Loa (eye worm) hypothetical protein 0.002 0.0216 0.0329
Loa Loa (eye worm) hypothetical protein 0.0037 0.0555 0.0844
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0065 0.111 0.1689
Trichomonas vaginalis esterase, putative 0.0037 0.0553 1
Brugia malayi Cytochrome P450 family protein 0.0016 0.0143 0.0283
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0203 0.3093
Echinococcus granulosus GPCR family 3 C terminal 0.002 0.0211 0.0226
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.002 0.0211 0.0211
Loa Loa (eye worm) RGS-3 protein 0.002 0.0211 0.0321
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0017 0.0159 0.0314
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.0011 0.0047 0.005
Schistosoma mansoni regulator of G protein signaling 0.002 0.0211 0.0211
Schistosoma mansoni regulator of G protein signaling 0.002 0.0211 0.0211
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0011 0.0047 0.005
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0019 0.0202 0.1465
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0037 0.0555 0.0594
Echinococcus multilocularis beta LACTamase domain containing family member 0.0037 0.0553 0.0593
Plasmodium falciparum apurinic/apyrimidinic endonuclease Apn1, putative 0.0078 0.1381 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.006 0.0091
Toxoplasma gondii ABC1 family protein 0.0037 0.0553 0.4009
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0056 0.0944 0.1011
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0045 0.0714 0.0765
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0013 0.0078 0.0505
Loa Loa (eye worm) hypothetical protein 0.0017 0.0159 0.0242
Trichomonas vaginalis guanylate cyclase, putative 0.0013 0.0078 0.0505
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0179 0.3376 0.3616
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0037 0.0553 0.0943
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0013 0.0078 0.0618
Loa Loa (eye worm) hypothetical protein 0.0031 0.0437 0.0665
Echinococcus granulosus tyrosine kinase 0.0011 0.0047 0.005
Echinococcus multilocularis jun protein 0.0179 0.3376 0.3616
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0011 0.0047 0.005
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0037 0.0555 0.0594
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0013 0.0078 0.0505
Brugia malayi hypothetical protein 0.0017 0.0159 0.0314
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0203 0.0402
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0037 0.0555 0.1095
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0013 0.0078 0.0119
Brugia malayi hypothetical protein 0.0039 0.0592 0.117
Loa Loa (eye worm) hypothetical protein 0.0095 0.1715 0.261
Schistosoma mansoni axis inhibition protein axin 0.002 0.0211 0.0211
Schistosoma mansoni serine/threonine protein kinase 0.002 0.0211 0.0211
Loa Loa (eye worm) hypothetical protein 0.0012 0.006 0.0091
Plasmodium vivax apurinic/apyrimidinic endonuclease Apn1, putative 0.0078 0.1381 1
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0203 0.5
Echinococcus multilocularis metabotropic glutamate receptor 2 0.0011 0.0047 0.005
Echinococcus multilocularis geminin 0.0173 0.3269 0.3501
Loa Loa (eye worm) hypothetical protein 0.0037 0.0555 0.0844
Loa Loa (eye worm) hypothetical protein 0.002 0.0213 0.0325
Brugia malayi Guanylyl cyclase protein 23 0.0011 0.0047 0.0092
Loa Loa (eye worm) metabotropic glutamate receptor 8 0.0011 0.0047 0.0071
Loa Loa (eye worm) nuclear hormone receptor 0.0045 0.0714 0.1087
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.002 0.0211 0.0211
Schistosoma mansoni hypothetical protein 0.003 0.0414 0.0414
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0002 0.0002
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0095 0.1715 0.3387
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0037 0.0555 0.1095
Loa Loa (eye worm) glutamate receptor 0.002 0.0211 0.0321
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0078 0.0505
Brugia malayi hypoxia-induced factor 1 0.0154 0.2885 0.5698
Brugia malayi nuclear hormone receptor 0.0095 0.1715 0.3387
Brugia malayi hypothetical protein 0.002 0.0222 0.0438
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0213 0.0422
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0203 0.5
Loa Loa (eye worm) hypothetical protein 0.0045 0.0714 0.1087
Brugia malayi Neuronal acetylcholine receptor protein, alpha-2 chain precursor 0.0017 0.0159 0.0314
Chlamydia trachomatis endonuclease IV 0.0078 0.1381 1
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0016 0.0142 0.0152
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0095 0.1715 0.3387
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0095 0.1715 0.1715
Onchocerca volvulus 0.0037 0.0555 0.1532
Echinococcus multilocularis regulator of G protein signaling 0.002 0.0211 0.0226
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0152 0.2857 0.306
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.002 0.0216 0.0216
Schistosoma mansoni hypothetical protein 0.002 0.0222 0.0222
Onchocerca volvulus 0.0017 0.0159 0.0339
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0037 0.0555 0.0844
Loa Loa (eye worm) hypothetical protein 0.003 0.0419 0.0637
Brugia malayi Common central domain of tyrosinase family protein 0.0178 0.3361 0.6639
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.005 0.0821 0.0821
Onchocerca volvulus 0.0012 0.006 0.004
Schistosoma mansoni single-minded 0.005 0.0811 0.0811
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0095 0.1715 0.1837
Onchocerca volvulus 0.0178 0.3361 1
Echinococcus granulosus axis inhibition protein axin 0.002 0.0211 0.0226
Brugia malayi Regulator of G protein signaling domain containing protein 0.002 0.0211 0.0416
Brugia malayi Nuclear hormone receptor-like 1 0.005 0.0821 0.1622
Loa Loa (eye worm) hypothetical protein 0.0045 0.0714 0.1087
Echinococcus granulosus nuclear factor of activated T cells 5 0.0152 0.2857 0.306
Brugia malayi CXXC zinc finger family protein 0.0029 0.0405 0.08
Schistosoma mansoni ap endonuclease 0.0019 0.0203 0.0203
Trypanosoma brucei unspecified product 0.0014 0.0092 0.0776
Onchocerca volvulus 0.0037 0.0553 0.1529
Schistosoma mansoni ankyrin 23/unc44 0.003 0.0414 0.0414
Onchocerca volvulus 0.0012 0.006 0.004
Brugia malayi hypothetical protein 0.0017 0.0159 0.0314
Brugia malayi conserved hypotetical protein 0.0045 0.0714 0.1411
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0203 0.031
Echinococcus granulosus gamma aminobutyric acid receptor subunit 0.0017 0.0159 0.0171
Echinococcus multilocularis glutamate receptor 2 0.0011 0.0047 0.005
Loa Loa (eye worm) hypothetical protein 0.0045 0.0714 0.1087
Loa Loa (eye worm) hypothetical protein 0.0037 0.0555 0.0844
Loa Loa (eye worm) hypothetical protein 0.0017 0.0159 0.0242
Loa Loa (eye worm) hypothetical protein 0.0012 0.006 0.0091
Echinococcus multilocularis expressed protein 0.0381 0.7417 0.7944
Plasmodium vivax multidomain scavenger receptor, putative 0.002 0.0222 0.1226
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0095 0.1715 0.261
Loa Loa (eye worm) hypothetical protein 0.0017 0.0159 0.0242
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0213 0.321
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0095 0.1715 0.1715
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.002 0.0213 0.3291
Leishmania major DNA polymerase kappa, putative 0.002 0.0213 0.3291
Loa Loa (eye worm) hypothetical protein 0.0031 0.0437 0.0665
Brugia malayi nuclear hormone receptor 0.0045 0.0714 0.1411
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0179 0.3376 0.3616
Echinococcus multilocularis gamma aminobutyric acid receptor subunit 0.0017 0.0159 0.0171
Echinococcus multilocularis Regulator of G protein signaling 20 0.002 0.0211 0.0226
Loa Loa (eye worm) hypothetical protein 0.0017 0.0159 0.0242
Brugia malayi hypothetical protein 0.0012 0.006 0.0119
Loa Loa (eye worm) ACC-1 protein 0.0037 0.0555 0.0844
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.002 0.0213 0.0325
Loa Loa (eye worm) hypothetical protein 0.0037 0.0555 0.0844
Echinococcus multilocularis beta adrenergic receptor kinase 0.002 0.0211 0.0226
Echinococcus multilocularis atrial natriuretic peptide receptor 0.0011 0.0047 0.005
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0045 0.0714 0.0714
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0553 1
Echinococcus granulosus nmda type glutamate receptor 0.0011 0.0047 0.005
Echinococcus granulosus glycine receptor subunit alpha 1 0.0037 0.0555 0.0594
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0037 0.0555 0.0594
Echinococcus granulosus beta LACTamase domain containing family member 0.0037 0.0553 0.0593
Loa Loa (eye worm) hypothetical protein 0.0012 0.006 0.0091
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0092 0.0776
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.003 0.0414 0.0629
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0037 0.0555 0.1095
Echinococcus granulosus glycine receptor subunit alpha 1 0.0037 0.0555 0.0594
Echinococcus multilocularis RUN 0.002 0.0222 0.0238
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0051 0.0835 0.165
Loa Loa (eye worm) hypothetical protein 0.002 0.0211 0.0321
Loa Loa (eye worm) hypothetical protein 0.0037 0.0555 0.0844
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0203 0.3093
Echinococcus multilocularis Polycystic kidney disease protein 0.002 0.0222 0.0238
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0553 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0159 0.0242
Echinococcus multilocularis ecdysone induced protein 78C 0.0095 0.1715 0.1837
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0016 0.0142 0.1885
Echinococcus granulosus geminin 0.0173 0.3269 0.3501
Echinococcus multilocularis glycine receptor subunit beta 0.0037 0.0555 0.0594
Loa Loa (eye worm) hypothetical protein 0.005 0.0821 0.125
Echinococcus granulosus atrial natriuretic peptide receptor 0.0011 0.0047 0.005
Loa Loa (eye worm) hypothetical protein 0.002 0.0216 0.0329
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0095 0.1715 0.3387
Echinococcus granulosus glycine receptor subunit beta 0.0037 0.0555 0.0594
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0142 0.0152
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0045 0.0714 0.0765
Loa Loa (eye worm) TAR-binding protein 0.0065 0.111 0.1689
Brugia malayi RNA binding protein 0.0065 0.111 0.2192
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0037 0.0555 0.1095
Loa Loa (eye worm) neuronal acetylcholine receptor protein 0.0017 0.0159 0.0242
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.002 0.0213 0.0163
Onchocerca volvulus 0.0045 0.0714 0.2014
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0051 0.0835 0.1271
Onchocerca volvulus 0.0037 0.0553 0.1529
Schistosoma mansoni tar DNA-binding protein 0.0065 0.111 0.111
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0011 0.0047 0.005
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0037 0.0553 0.1093
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0095 0.1715 0.3387
Schistosoma mansoni hypothetical protein 0.0035 0.0514 0.0514
Onchocerca volvulus 0.002 0.0222 0.0529
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0045 0.0714 0.0765
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.002 0.0211 0.0226
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0405 0.0617
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0213 0.321
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.002 0.0211 0.3158
Brugia malayi PXA domain containing protein 0.002 0.0211 0.0416
Mycobacterium tuberculosis Conserved protein 0.0037 0.0553 0.0943
Schistosoma mansoni nAChR subunit 0.0037 0.0555 0.0555
Loa Loa (eye worm) hypothetical protein 0.0037 0.0555 0.0844
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0553 0.0553
Loa Loa (eye worm) hypothetical protein 0.0045 0.0714 0.1087
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0016 0.0142 0.0622
Schistosoma mansoni c4b-binding protein beta chain 0.0012 0.006 0.006
Schistosoma mansoni retinoid-x-receptor (RXR) 0.005 0.0821 0.0821
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0037 0.0555 0.1095
Loa Loa (eye worm) hypothetical protein 0.0017 0.0167 0.0254
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0095 0.1715 0.261
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0037 0.0555 0.0594
Loa Loa (eye worm) hypothetical protein 0.0045 0.0714 0.1087
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0037 0.0555 0.0594
Brugia malayi pregnancy-associated plasma protein-A 0.0012 0.006 0.0119
Echinococcus multilocularis neuropeptide s receptor 0.0478 0.9337 1
Leishmania major protein kinase, putative 0.0013 0.0078 0.0618
Loa Loa (eye worm) hypothetical protein 0.0017 0.0159 0.0242
Schistosoma mansoni tyrosine kinase 0.0011 0.0047 0.0047
Loa Loa (eye worm) hypothetical protein 0.0012 0.006 0.0091
Loa Loa (eye worm) hypothetical protein 0.0045 0.0714 0.1087
Brugia malayi Cation transporter family protein 0.0037 0.0555 0.1095
Loa Loa (eye worm) hypothetical protein 0.005 0.0821 0.125
Trypanosoma brucei cytochrome P450, putative 0.0016 0.0143 0.1804
Onchocerca volvulus 0.0012 0.006 0.004
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0045 0.0714 0.1087
Onchocerca volvulus 0.0037 0.0555 0.1532
Entamoeba histolytica hypothetical protein 0.0039 0.0592 1
Loa Loa (eye worm) hypothetical protein 0.003 0.0414 0.0629
Schistosoma mansoni hypothetical protein 0.002 0.0211 0.0211
Loa Loa (eye worm) hypothetical protein 0.002 0.0211 0.0321
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0037 0.0555 0.1095
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0203 0.0218
Loa Loa (eye worm) cytochrome P450 family protein 0.0027 0.0353 0.0537
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0015 0.0111 0.0803
Trichomonas vaginalis DNA helicase recq, putative 0.0022 0.0255 0.4039
Brugia malayi Calcitonin receptor-like protein seb-1 0.0051 0.0835 0.165
Echinococcus granulosus RUN 0.002 0.0222 0.0238
Loa Loa (eye worm) hypothetical protein 0.0045 0.0714 0.1087
Loa Loa (eye worm) cytochrome P450 family protein 0.0016 0.0143 0.0218
Brugia malayi GCC2 and GCC3 family protein 0.0012 0.006 0.0119
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0211 0.3158
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0095 0.1715 0.3387
Onchocerca volvulus 0.0013 0.0078 0.0094
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0013 0.0078 0.0618
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0017 0.0159 0.0171
Onchocerca volvulus Putative hydroxypyruvate isomerase 0.0021 0.0231 0.0556
Schistosoma mansoni terminal deoxycytidyl transferase 0.002 0.0213 0.0213
Brugia malayi regulator of G-protein signaling rgs-7 0.002 0.0211 0.0416
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0037 0.0555 0.0594
Plasmodium vivax hypothetical protein, conserved 0.0037 0.0553 0.3736
Brugia malayi Sushi domain 0.0012 0.006 0.0119
Loa Loa (eye worm) hypothetical protein 0.0051 0.0835 0.1271
Brugia malayi hypothetical protein 0.0017 0.0159 0.0314
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0553 1
Trichomonas vaginalis adenylate cyclase, putative 0.0013 0.0078 0.0505
Schistosoma mansoni hypothetical protein 0.0418 0.8145 0.8145
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.003 0.0414 0.0443
Brugia malayi Cytochrome P450 family protein 0.0016 0.0143 0.0283
Loa Loa (eye worm) hypothetical protein 0.005 0.0821 0.125
Schistosoma mansoni steroid hormone receptor ad4bp 0.0095 0.1715 0.1715
Echinococcus granulosus Polycystic kidney disease protein 0.002 0.0222 0.0238
Echinococcus granulosus c4b binding protein beta chain 0.0012 0.006 0.0064
Echinococcus granulosus nAChR subunit 0.002 0.0216 0.0231
Echinococcus granulosus regulator of G protein signaling 7 0.002 0.0211 0.0226
Brugia malayi hypothetical protein 0.014 0.2613 0.516
Brugia malayi Nuclear hormone receptor-like 1 0.005 0.0821 0.1622
Echinococcus multilocularis dna polymerase eta 0.002 0.0213 0.0229
Echinococcus multilocularis nmda type glutamate receptor 0.0011 0.0047 0.005
Loa Loa (eye worm) hypothetical protein 0.0051 0.0827 0.1259
Brugia malayi metabotropic GABA-B receptor subtype 2 0.0263 0.5063 1
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.005 0.0821 0.125
Schistosoma mansoni z-protein (S1r protein) 0.002 0.0211 0.0211
Loa Loa (eye worm) hypothetical protein 0.0095 0.1715 0.261
Onchocerca volvulus 0.0029 0.0405 0.1081
Brugia malayi hypothetical protein 0.0017 0.0159 0.0314
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0095 0.1715 0.261
Brugia malayi Hypothetical tyrosinase-like protein C02C2.1 in chromosome III 0.0178 0.3361 0.6639
Onchocerca volvulus 0.0012 0.006 0.004
Entamoeba histolytica deoxycytidyl transferase, putative 0.002 0.0213 0.3055
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0142 0.1885
Onchocerca volvulus 0.0012 0.006 0.004
Schistosoma mansoni nuclear receptor nhr-48 0.0045 0.0714 0.0714
Loa Loa (eye worm) hypothetical protein 0.0017 0.0159 0.0242
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0553 1
Schistosoma mansoni neurotransmitter gated ion channel 0.0017 0.0159 0.0159
Loa Loa (eye worm) hypothetical protein 0.0011 0.0047 0.0071
Schistosoma mansoni tar DNA-binding protein 0.0065 0.111 0.111
Brugia malayi Uncoordinated protein 44 0.003 0.0414 0.0817
Schistosoma mansoni metabotropic glutamate receptor 0.0011 0.0047 0.0047
Echinococcus granulosus dna polymerase kappa 0.002 0.0213 0.0229
Schistosoma mansoni hypothetical protein 0.0173 0.3269 0.3269
Brugia malayi regulator of G-protein signaling egl-10 0.002 0.0211 0.0416
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.002 0.0211 0.0226
Echinococcus granulosus metabotropic glutamate receptor 5 0.0031 0.0437 0.0468
Echinococcus granulosus nAChR subunit 0.0037 0.0555 0.0594
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0095 0.1715 0.1837
Brugia malayi A-kinase anchor protein 10, precursor 0.002 0.0211 0.0416
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0213 0.321
Onchocerca volvulus 0.002 0.0222 0.0529
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0213 0.0422
Loa Loa (eye worm) hypothetical protein 0.0037 0.0555 0.0844
Brugia malayi Hypothetical tyrosinase-like protein F21C3.2 in chromosome I 0.0178 0.3361 0.6639
Loa Loa (eye worm) hypothetical protein 0.0045 0.0714 0.1087
Onchocerca volvulus 0.0037 0.0553 0.1529

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 250 nM Binding affinity of the compound towards human Endothelin A receptor by measuring its ability to displace [125I]-ET-1 from CHO cells ChEMBL. 8667356
Ki (binding) = 250 nM Binding affinity of the compound towards human Endothelin A receptor by measuring its ability to displace [125I]-ET-1 from CHO cells ChEMBL. 8667356
Ki (binding) = 3000 nM Binding affinity of the compound towards human Endothelin B receptor by measuring its ability to displace [125I]-ET-3 from CHO cells ChEMBL. 8667356
Ki (binding) = 3000 nM Binding affinity of the compound towards human Endothelin B receptor by measuring its ability to displace [125I]-ET-3 from CHO cells ChEMBL. 8667356

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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