Detailed information for compound 1118137

Basic information

Technical information
  • TDR Targets ID: 1118137
  • Name: 2-dimethylaminoethyl 2-(4-chlorophenyl)acetat e; hydron; chloride
  • MW: 278.175 | Formula: C12H17Cl2NO2
  • H donors: 0 H acceptors: 1 LogP: 3.18 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CN(CCOC(=O)Cc1ccc(cc1)Cl)C.Cl
  • InChi: 1S/C12H16ClNO2.ClH/c1-14(2)7-8-16-12(15)9-10-3-5-11(13)6-4-10;/h3-6H,7-9H2,1-2H3;1H
  • InChiKey: WOUQFKVCHNNNNC-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-dimethylaminoethyl 2-(4-chlorophenyl)acetate hydrochloride
  • 2-(4-chlorophenyl)acetic acid 2-dimethylaminoethyl ester hydrochloride
  • 2-(4-chlorophenyl)acetic acid 2-dimethylaminoethyl ester; hydron; chloride
  • 2-dimethylaminoethyl 2-(4-chlorophenyl)ethanoate hydrochloride
  • 2-dimethylaminoethyl 2-(4-chlorophenyl)ethanoate; hydron; chloride
  • MLS000036544
  • SMR000042104

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi oxidoreductase-like protein, putative 0.0031 0.0059 0.0229
Schistosoma mansoni jumonji domain containing protein 0.0027 0.0038 0.0022
Trypanosoma cruzi metacaspase, putative 0.0045 0.0136 0.064
Echinococcus granulosus microtubule associated protein 2 0.0737 0.3906 0.3997
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0027 0.0036 0.0405
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0047 0.0147 0.0133
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0047 0.0147 0.0133
Echinococcus granulosus GPCR family 2 0.0052 0.017 0.0157
Brugia malayi WGR domain containing protein 0.0239 0.119 0.1205
Echinococcus granulosus lamin 0.0028 0.0039 0.0023
Loa Loa (eye worm) hypothetical protein 0.0112 0.0497 0.0493
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0047 0.0147 0.2109
Loa Loa (eye worm) hypothetical protein 0.0166 0.0796 0.08
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0047 0.0147 0.0133
Echinococcus multilocularis musashi 0.0028 0.0039 0.0022
Echinococcus multilocularis metabotropic glutamate receptor 2 0.021 0.1032 0.1016
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0047 0.0147 0.0133
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0045 0.0136 0.1541
Echinococcus granulosus g protein coupled receptor 0.0047 0.0147 0.0133
Echinococcus multilocularis neuroligin 0.0045 0.0135 0.0119
Loa Loa (eye worm) glutamate receptor 0.025 0.1253 0.127
Entamoeba histolytica hypothetical protein 0.0067 0.0256 0.1069
Loa Loa (eye worm) hypothetical protein 0.0078 0.0314 0.0305
Entamoeba histolytica protein kinase, putative 0.0093 0.0398 0.1702
Schistosoma mansoni hypothetical protein 0.0346 0.1773 0.1804
Schistosoma mansoni hypothetical protein 0.0346 0.1773 0.1804
Echinococcus multilocularis sterol regulatory element binding protein 0.0097 0.0415 0.0399
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0041 0.0109 0.0197
Schistosoma mansoni chromosome transmission fidelity factor 0.004 0.0104 0.009
Schistosoma mansoni hypothetical protein 0.0052 0.017 0.0157
Brugia malayi Intermediate filament tail domain containing protein 0.0028 0.0039 0.0023
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0064 0.0729
Echinococcus granulosus tumor protein p63 0.0382 0.1969 0.2007
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.012 0.0542 0.0526
Brugia malayi hypothetical protein 0.0047 0.0147 0.0133
Loa Loa (eye worm) hypothetical protein 0.0047 0.0147 0.0133
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0054 0.0182 0.2072
Brugia malayi hypothetical protein 0.0047 0.0147 0.0133
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0047 0.0147 0.0133
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.012 0.0543 0.1901
Mycobacterium tuberculosis Probable oxidoreductase 0.0134 0.0617 0.2188
Schistosoma mansoni histamine h1 receptor 0.0047 0.0147 0.0133
Mycobacterium ulcerans putative regulatory protein 0.0039 0.0101 0.0503
Trichomonas vaginalis CAMK family protein kinase 0.0112 0.05 0.5686
Trypanosoma cruzi metacaspase, putative 0.0045 0.0136 0.064
Loa Loa (eye worm) hypothetical protein 0.0097 0.0415 0.041
Mycobacterium leprae Probable lipase LipE 0.0078 0.0314 0.2736
Loa Loa (eye worm) hypothetical protein 0.0364 0.1872 0.1906
Plasmodium vivax metacaspase 1, putative 0.0045 0.0136 0.1161
Brugia malayi Metabotropic glutamate receptor precursor. 0.025 0.1253 0.127
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0045 0.0136 0.1541
Schistosoma mansoni myosin xvIII 0.0047 0.0147 0.0133
Loa Loa (eye worm) hypothetical protein 0.0047 0.0147 0.0133
Schistosoma mansoni hypothetical protein 0.0082 0.0337 0.0329
Onchocerca volvulus 0.0047 0.0147 0.2109
Echinococcus granulosus apoptotic protease activating factor 1 0.0042 0.0119 0.0105
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0054 0.0182 0.2072
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0054 0.0182 0.2072
Echinococcus multilocularis sex peptide receptor 0.0047 0.0147 0.013
Onchocerca volvulus 0.0047 0.0147 0.2109
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0135 0.0121
Leishmania major oxidoreductase-like protein 0.0031 0.0059 0.0229
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0093 0.0398 0.2055
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0078 0.0314 0.1
Echinococcus granulosus sterol regulatory element binding protein 0.0097 0.0415 0.041
Brugia malayi Dopamine receptor 0.0047 0.0147 0.0133
Brugia malayi beta-lactamase family protein 0.0078 0.0314 0.0305
Loa Loa (eye worm) hypothetical protein 0.0065 0.0244 0.0233
Schistosoma mansoni topbp1 0.004 0.0104 0.009
Loa Loa (eye worm) hypothetical protein 0.0047 0.0147 0.0133
Mycobacterium tuberculosis Conserved protein 0.0078 0.0314 0.1
Loa Loa (eye worm) hypothetical protein 0.0073 0.0288 0.0278
Schistosoma mansoni hypothetical protein 0.0047 0.0147 0.0133
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0064 0.0729
Loa Loa (eye worm) hypothetical protein 0.0047 0.0147 0.0133
Echinococcus granulosus g protein coupled receptor 0.0047 0.0147 0.0133
Trichomonas vaginalis chromobox protein, putative 0.0047 0.0147 0.1674
Loa Loa (eye worm) hypothetical protein 0.0047 0.0147 0.0133
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.0228 0.2052
Brugia malayi AMP-binding enzyme family protein 0.0054 0.0184 0.0172
Plasmodium falciparum enoyl-acyl carrier reductase 0.0182 0.088 1
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0104 0.1182
Echinococcus granulosus GPCR family 3 C terminal 0.0041 0.011 0.0096
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0054 0.0182 0.2072
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0101 0.1143
Onchocerca volvulus 0.0047 0.0147 0.2109
Schistosoma mansoni hypothetical protein 0.0052 0.017 0.0157
Loa Loa (eye worm) hypothetical protein 0.0163 0.0778 0.0782
Echinococcus granulosus lysine specific demethylase 6a 0.0027 0.0038 0.0022
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0054 0.0182 0.2072
Brugia malayi hypothetical protein 0.0047 0.0147 0.0133
Echinococcus multilocularis thioredoxin glutathione reductase 0.0053 0.0176 0.0159
Echinococcus granulosus serotonin receptor 0.0047 0.0147 0.0133
Echinococcus granulosus g-protein coupled receptor 0.0047 0.0147 0.0133
Echinococcus multilocularis neuropeptides capa receptor 0.0047 0.0147 0.013
Trypanosoma brucei polo-like protein kinase 0.0112 0.05 0.2522
Trypanosoma cruzi metacaspase 5, putative 0.0045 0.0136 0.064
Schistosoma mansoni opsin-like receptor 0.0047 0.0147 0.0133
Trypanosoma brucei metacaspase 5, putative 0.0045 0.0136 0.0533
Trypanosoma cruzi metacaspase, putative 0.0045 0.0136 0.064
Onchocerca volvulus Huntingtin homolog 0.0136 0.0632 1
Trypanosoma brucei Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region/Zinc-finger (CX5CX6HX5H) motif containing protein, putative 0.0057 0.0198 0.0872
Schistosoma mansoni aldehyde dehydrogenase 0.0062 0.0228 0.0217
Loa Loa (eye worm) hypothetical protein 0.0047 0.0147 0.0133
Echinococcus multilocularis expressed conserved protein 0.0212 0.1042 0.1027
Echinococcus granulosus G protein coupled receptor 139 0.0047 0.0147 0.0133
Trichomonas vaginalis chromobox protein, putative 0.0079 0.0318 0.3609
Echinococcus granulosus histone acetyltransferase KAT2B 0.0138 0.0643 0.0644
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.0093 0.0398 0.0392
Loa Loa (eye worm) acetyltransferase 0.0142 0.0665 0.0666
Schistosoma mansoni ets-related 0.0232 0.1151 0.1165
Loa Loa (eye worm) hypothetical protein 0.0425 0.2205 0.2248
Onchocerca volvulus 0.0045 0.0135 0.1924
Onchocerca volvulus Serine\/threonine kinase homolog 0.0112 0.05 0.7855
Echinococcus multilocularis g-protein coupled receptor 0.0047 0.0147 0.013
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0047 0.0147 0.0133
Loa Loa (eye worm) cytochrome P450 family protein 0.0034 0.0073 0.0058
Brugia malayi Tnks protein 0.0032 0.0064 0.0049
Brugia malayi G protein-coupled receptor 0.0047 0.0147 0.0133
Brugia malayi Carboxylesterase family protein 0.0045 0.0135 0.0122
Trichomonas vaginalis CAMK family protein kinase 0.0112 0.05 0.5686
Echinococcus granulosus poly (ADP ribose) polymerase 0.0067 0.0256 0.0246
Plasmodium vivax glutathione reductase, putative 0.0053 0.0176 0.1637
Echinococcus granulosus cpg binding protein 0.0066 0.0247 0.0237
Loa Loa (eye worm) hypothetical protein 0.0045 0.0135 0.0122
Echinococcus multilocularis G protein coupled receptor 139 0.0047 0.0147 0.013
Echinococcus multilocularis chromobox protein 1 0.0079 0.0318 0.0301
Loa Loa (eye worm) hypothetical protein 0.0033 0.0068 0.0053
Echinococcus multilocularis serotonin receptor 0.0293 0.1484 0.147
Onchocerca volvulus 0.0045 0.0135 0.1924
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0026 0.0031 0.0015
Toxoplasma gondii thioredoxin reductase 0.0053 0.0176 0.0566
Loa Loa (eye worm) hypothetical protein 0.0047 0.0147 0.0133
Brugia malayi jmjC domain containing protein 0.0027 0.0038 0.0022
Trichomonas vaginalis D-aminoacylase, putative 0.0078 0.0314 0.3566
Toxoplasma gondii hypothetical protein 0.0039 0.0101 0.0258
Echinococcus granulosus biogenic amine 5HT receptor 0.0293 0.1484 0.1508
Echinococcus granulosus phd:f box containing protein 0.0027 0.0038 0.0022
Echinococcus multilocularis poly (ADP ribose) polymerase 0.01 0.0432 0.0416
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0045 0.0136 0.1541
Brugia malayi metabotropic glutamate receptor subtype 5a (mGluR5a), putative 0.0227 0.1125 0.1139
Echinococcus granulosus PHD finger protein rhinoceros 0.0033 0.0068 0.0053
Echinococcus granulosus beta LACTamase domain containing family member 0.0078 0.0314 0.0305
Loa Loa (eye worm) hypothetical protein 0.0118 0.0534 0.0531
Schistosoma mansoni tar DNA-binding protein 0.0136 0.0628 0.0628
Onchocerca volvulus Huntingtin homolog 0.0136 0.0632 1
Onchocerca volvulus DNA ligase 3 homolog 0.0057 0.0198 0.2938
Echinococcus multilocularis poly (adp ribose) polymerase 2 0.0239 0.119 0.1175
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0047 0.0147 0.0133
Mycobacterium tuberculosis Two component sensor histidine kinase DevS 0.0039 0.0101 0.0162
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.012 0.0542 0.054
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0136 0.1541
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0027 0.0036 0.0405
Trichomonas vaginalis penicillin-binding protein, putative 0.0078 0.0314 0.3566
Schistosoma mansoni alpha-1 adrenergic receptor 0.0047 0.0147 0.0133
Loa Loa (eye worm) hypothetical protein 0.0268 0.1349 0.1369
Echinococcus granulosus geminin 0.0346 0.1773 0.1804
Trypanosoma brucei BRCA1 C Terminus (BRCT) domain containing protein, putative 0.004 0.0104 0.0361
Trypanosoma cruzi polo-like protein kinase, putative 0.0112 0.05 0.2607
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0047 0.0147 0.0133
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0047 0.0147 0.0133
Echinococcus granulosus histone acetyltransferase KAT2B 0.0042 0.0117 0.0103
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0136 0.1541
Brugia malayi chromobox protein homolog 3 0.0044 0.0129 0.0115
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0054 0.0182 0.2072
Plasmodium falciparum histone acetyltransferase GCN5 0.0038 0.0098 0.0714
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0054 0.0184 0.1521
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0135 0.0121
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0047 0.0147 0.0133
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0045 0.0136 0.0402
Loa Loa (eye worm) hypothetical protein 0.0056 0.0193 0.0181
Onchocerca volvulus 0.0042 0.0119 0.1654
Echinococcus granulosus MAP kinase activated protein kinase 2 0.1808 0.9747 1
Schistosoma mansoni hypothetical protein 0.0033 0.0068 0.0053
Echinococcus multilocularis apoptotic protease activating factor 1 0.0042 0.0119 0.0102
Echinococcus granulosus rhodopsin orphan GPCR 0.0047 0.0147 0.0133
Trichomonas vaginalis D-aminoacylase, putative 0.0078 0.0314 0.3566
Loa Loa (eye worm) heterochromatin protein 1 0.0079 0.0318 0.0309
Echinococcus multilocularis neuropeptide Y receptor 0.0047 0.0147 0.013
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0047 0.0147 0.0133
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0268 0.1349 0.1369
Echinococcus granulosus BC026374 protein S09 family 0.0045 0.0135 0.0122
Schistosoma mansoni tar DNA-binding protein 0.0136 0.0628 0.0628
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0052 0.017 0.0153
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0047 0.0147 0.013
Loa Loa (eye worm) hypothetical protein 0.0047 0.0147 0.0133
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0054 0.0182 0.2072
Brugia malayi metabotropic GABA-B receptor subtype 2 0.0041 0.011 0.0096
Schistosoma mansoni tar DNA-binding protein 0.0136 0.0628 0.0628
Schistosoma mansoni survival motor neuron protein 0.0056 0.0193 0.0181
Brugia malayi Carboxylesterase family protein 0.0268 0.1349 0.1369
Loa Loa (eye worm) hypothetical protein 0.0047 0.0147 0.0133
Schistosoma mansoni hypothetical protein 0.0047 0.0147 0.0133
Schistosoma mansoni hypothetical protein 0.0093 0.0396 0.039
Mycobacterium ulcerans hypothetical protein 0.0054 0.0184 0.1521
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0078 0.0314 0.0305
Onchocerca volvulus 0.0047 0.0147 0.2109
Trypanosoma cruzi metacaspase 5, putative 0.0045 0.0136 0.064
Brugia malayi jmjC domain containing protein 0.0027 0.0038 0.0022
Loa Loa (eye worm) hypothetical protein 0.0274 0.1381 0.1402
Loa Loa (eye worm) hypothetical protein 0.0047 0.0147 0.0133
Echinococcus multilocularis survival motor neuron protein 1 0.0274 0.1381 0.1366
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0142 0.0665 0.0649
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0134 0.0617 0.662
Schistosoma mansoni protein phosphatase 2C 0.0027 0.0038 0.0022
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0047 0.0147 0.0133
Schistosoma mansoni amine GPCR 0.0388 0.2001 0.2039
Echinococcus granulosus neuropeptide receptor 0.0047 0.0147 0.0133
Loa Loa (eye worm) hypothetical protein 0.0047 0.0147 0.0133
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0047 0.0147 0.0133
Echinococcus granulosus neuropeptides capa receptor 0.0047 0.0147 0.0133
Schistosoma mansoni opsin-like receptor 0.0047 0.0147 0.0133
Echinococcus multilocularis acetylcholinesterase 0.0268 0.1349 0.1334
Brugia malayi mucosa associated lymphoid tissue lymphoma translocation protein 1 0.0045 0.0136 0.0122
Onchocerca volvulus 0.0047 0.0147 0.2109
Loa Loa (eye worm) hypothetical protein 0.0088 0.0366 0.0359
Echinococcus granulosus WGR domain containing protein 0.0135 0.0624 0.0624
Loa Loa (eye worm) hypothetical protein 0.0041 0.011 0.0096
Echinococcus multilocularis orexin receptor type 2 0.0047 0.0147 0.013
Echinococcus granulosus Protein patched homolog 1 0.0097 0.0415 0.041
Echinococcus granulosus g protein coupled receptor 0.0047 0.0147 0.0133
Echinococcus multilocularis peregrin 0.0036 0.0087 0.007
Plasmodium vivax hypothetical protein, conserved 0.0078 0.0314 0.3277
Plasmodium falciparum phd finger protein, putative 0.0033 0.0068 0.036
Echinococcus granulosus expressed conserved protein 0.0212 0.1042 0.1053
Echinococcus granulosus Niemann Pick C1 protein 0.0225 0.1116 0.113
Schistosoma mansoni poly [ADP-ribose] polymerase 0.0434 0.2257 0.2302
Schistosoma mansoni neuropeptide receptor 0.0047 0.0147 0.0133
Loa Loa (eye worm) neuropeptide F receptor 0.0047 0.0147 0.0133
Onchocerca volvulus 0.0056 0.0193 0.2863
Loa Loa (eye worm) hypothetical protein 0.0041 0.0109 0.0095
Loa Loa (eye worm) jmjC domain-containing protein 0.0027 0.0038 0.0022
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0134 0.0617 0.2188
Echinococcus multilocularis lysine specific demethylase 5A 0.0103 0.0448 0.0432
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0047 0.0147 0.0133
Loa Loa (eye worm) beta-lactamase 0.0078 0.0314 0.0305
Mycobacterium ulcerans beta-lactamase 0.0078 0.0314 0.3101
Plasmodium falciparum GAF domain-related protein, putative 0.0039 0.0101 0.0745
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0056 0.0193 0.0181
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0142 0.0665 0.0666
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.012 0.0543 0.5682
Echinococcus multilocularis jumonji domain containing protein 0.0046 0.0138 0.0122
Brugia malayi hypothetical protein 0.0136 0.0632 0.0633
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.004 0.0104 0.1182
Giardia lamblia Kinase, PLK 0.0112 0.05 1
Plasmodium falciparum metacaspase-like protein 0.0045 0.0136 0.1161
Loa Loa (eye worm) hypothetical protein 0.0045 0.0135 0.0122
Schistosoma mansoni neuropeptide receptor 0.0047 0.0147 0.0133
Echinococcus granulosus neuropeptide Y receptor 0.0047 0.0147 0.0133
Loa Loa (eye worm) metabotropic GABA-B receptor subtype 2 0.0064 0.0238 0.0228
Echinococcus multilocularis lamin 0.0028 0.0039 0.0022
Schistosoma mansoni microtubule-associated protein tau 0.0737 0.3906 0.3997
Plasmodium falciparum acyl-CoA synthetase 0.0041 0.0109 0.0851
Loa Loa (eye worm) hypothetical protein 0.0047 0.0147 0.0133
Brugia malayi Thioredoxin reductase 0.0053 0.0176 0.0163
Echinococcus multilocularis Niemann Pick C1 protein 0.0225 0.1116 0.1101
Trypanosoma brucei DNA repair protein, putative 0.0057 0.0198 0.0872
Mycobacterium ulcerans acyl-CoA synthetase 0.0054 0.0184 0.1521
Echinococcus granulosus rhodopsin orphan GPCR 0.0047 0.0147 0.0133
Loa Loa (eye worm) hypothetical protein 0.0041 0.0109 0.0095
Loa Loa (eye worm) hypothetical protein 0.0047 0.0147 0.0133
Loa Loa (eye worm) hypothetical protein 0.0464 0.2417 0.2466
Echinococcus granulosus caspase 2 0.0088 0.0366 0.0359
Echinococcus granulosus neuroligin 0.0045 0.0135 0.0122
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0101 0.1143
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0054 0.0184 0.049
Echinococcus multilocularis protein patched 0.0097 0.0415 0.0399
Leishmania major hypothetical protein, conserved 0.0027 0.0038 0.0113
Plasmodium vivax hypothetical protein, conserved 0.0039 0.0101 0.0745
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0054 0.0182 0.2072
Echinococcus granulosus tm gpcr rhodopsin 0.0047 0.0147 0.0133
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0064 0.0729
Schistosoma mansoni metabotropic glutamate receptor 0.021 0.1032 0.1043
Schistosoma mansoni cpg binding protein 0.0066 0.0247 0.0237
Schistosoma mansoni hypothetical protein 0.0047 0.0147 0.0133
Brugia malayi serine/threonine-protein kinase plk-2 0.0112 0.05 0.0497
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.0479 0.2498 0.255
Loa Loa (eye worm) hypothetical protein 0.0136 0.0632 0.0633
Echinococcus multilocularis cpg binding protein 0.0066 0.0247 0.0231
Trypanosoma brucei Metacaspase-4 0.0045 0.0136 0.0533
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.0054 0.0182 0.017
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0135 0.0121
Mycobacterium tuberculosis Probable dehydrogenase 0.012 0.0543 0.1901
Schistosoma mansoni neuropeptide F-like receptor 0.0047 0.0147 0.0133
Brugia malayi WGR domain containing protein 0.0434 0.2257 0.2302
Schistosoma mansoni caspase-7 (C14 family) 0.0088 0.0366 0.0359
Trypanosoma cruzi BRCA1 C Terminus (BRCT) domain containing protein, putative 0.004 0.0104 0.047
Loa Loa (eye worm) hypothetical protein 0.0047 0.0147 0.0133
Echinococcus granulosus tm gpcr rhodopsin 0.0047 0.0147 0.0133
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0047 0.0147 0.013
Trypanosoma cruzi trypanothione reductase, putative 0.0053 0.0176 0.0856
Leishmania major cytochrome p450-like protein 0.0034 0.0073 0.0302
Onchocerca volvulus 0.0035 0.0079 0.1009
Onchocerca volvulus 0.0056 0.0193 0.286
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0027 0.0036 0.0405
Trichomonas vaginalis CAMK family protein kinase 0.0112 0.05 0.5686
Brugia malayi follicle stimulating hormone receptor 0.0047 0.0147 0.0133
Loa Loa (eye worm) hypothetical protein 0.0047 0.0147 0.0133
Trichomonas vaginalis D-aminoacylase, putative 0.0078 0.0314 0.3566
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.012 0.0543 0.1901
Schistosoma mansoni serine/threonine protein kinase 0.1808 0.9747 1
Loa Loa (eye worm) hypothetical protein 0.0078 0.0314 0.0305
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0054 0.0182 0.2072
Echinococcus granulosus neuropeptide FF receptor 2 0.0047 0.0147 0.0133
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0132 0.0608 0.0608
Loa Loa (eye worm) acetylcholinesterase 1 0.0268 0.1349 0.1369
Schistosoma mansoni hypothetical protein 0.0047 0.0147 0.0133
Loa Loa (eye worm) hypothetical protein 0.0044 0.0129 0.0115
Schistosoma mansoni hypothetical protein 0.0112 0.0497 0.0493
Loa Loa (eye worm) hypothetical protein 0.0047 0.0147 0.0133
Leishmania major trypanothione reductase 0.0053 0.0176 0.0856
Toxoplasma gondii aldehyde dehydrogenase 0.0062 0.0228 0.078
Brugia malayi latrophilin 2 splice variant baaae 0.0112 0.0497 0.0493
Entamoeba histolytica hypothetical protein 0.0082 0.0337 0.143
Brugia malayi putative neuropeptide receptor 0.0047 0.0147 0.0133
Brugia malayi Ets-domain containing protein 0.0076 0.0304 0.0295
Echinococcus multilocularis caspase 8 0.0045 0.0136 0.0119
Echinococcus multilocularis GA binding protein alpha chain 0.0076 0.0304 0.0288
Schistosoma mansoni lamin 0.0028 0.0039 0.0023
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0031 0.0057 0.004
Echinococcus granulosus chromobox protein 1 0.0079 0.0318 0.0309
Onchocerca volvulus 0.0078 0.0314 0.4824
Loa Loa (eye worm) hypothetical protein 0.0054 0.0184 0.0172
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.0228 0.2052
Onchocerca volvulus 0.0047 0.0147 0.2109
Echinococcus granulosus neuropeptide s receptor 0.0047 0.0147 0.0133
Trypanosoma cruzi FHA domain containing protein, putative 0.004 0.0104 0.047
Loa Loa (eye worm) hypothetical protein 0.0047 0.0147 0.0133
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0062 0.0228 0.0217
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0104 0.047
Brugia malayi neuropeptide F receptor 0.0047 0.0147 0.0133
Schistosoma mansoni metabotropic glutamate receptor 0.0122 0.0554 0.0552
Echinococcus multilocularis rhodopsin orphan GPCR 0.0047 0.0147 0.013
Loa Loa (eye worm) hypothetical protein 0.0078 0.0314 0.0305
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0171 0.0819 0.0803
Schistosoma mansoni hypothetical protein 0.0093 0.0396 0.039
Brugia malayi hypothetical protein 0.0047 0.0147 0.0133
Echinococcus granulosus nibrin 0.004 0.0104 0.009
Plasmodium falciparum thioredoxin reductase 0.0053 0.0176 0.1637
Onchocerca volvulus 0.0047 0.0147 0.2109
Echinococcus granulosus jumonji domain containing 1A 0.0027 0.0038 0.0022
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0027 0.0036 0.0405
Echinococcus multilocularis BC026374 protein (S09 family) 0.0045 0.0135 0.0119
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0054 0.0182 0.2072
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0042 0.0117 0.0325
Schistosoma mansoni BC026374 protein (S09 family) 0.0045 0.0135 0.0122
Loa Loa (eye worm) hypothetical protein 0.004 0.0104 0.009
Schistosoma mansoni neuroligin 3 (S09 family) 0.0045 0.0135 0.0122
Loa Loa (eye worm) hypothetical protein 0.0078 0.0314 0.0305
Trichomonas vaginalis hypothetical protein 0.0182 0.088 1
Echinococcus granulosus somatostatin receptor 0.0047 0.0147 0.0133
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0104 0.1182
Echinococcus granulosus rhodopsin orphan GPCR 0.0047 0.0147 0.0133
Loa Loa (eye worm) hypothetical protein 0.0035 0.0077 0.0062
Loa Loa (eye worm) jmjC domain-containing protein 0.0106 0.0468 0.0463
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0229 0.1135 0.1149
Trypanosoma cruzi metacaspase, putative 0.0045 0.0136 0.064
Loa Loa (eye worm) glutamate receptor 0.0098 0.0425 0.042
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0027 0.0036 0.0405
Schistosoma mansoni hypothetical protein 0.0052 0.017 0.0157
Echinococcus multilocularis carboxylesterase 5A 0.0268 0.1349 0.1334
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0112 0.05 0.0497
Echinococcus granulosus rhodopsin orphan GPCR 0.0047 0.0147 0.0133
Onchocerca volvulus 0.0047 0.0147 0.2109
Mycobacterium ulcerans acyl-CoA synthetase 0.0054 0.0184 0.1521
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0135 0.0121
Mycobacterium tuberculosis Putative ferredoxin reductase 0.012 0.0543 0.1901
Brugia malayi jmjC domain containing protein 0.0106 0.0468 0.0463
Brugia malayi hypothetical protein 0.0045 0.0135 0.0122
Echinococcus multilocularis lysine specific demethylase 6a 0.0027 0.0038 0.0021
Brugia malayi intermediate filament protein 0.0028 0.0039 0.0023
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0054 0.0182 0.2072
Loa Loa (eye worm) hypothetical protein 0.0047 0.0147 0.0133
Loa Loa (eye worm) G-protein coupled receptor 0.0047 0.0147 0.0133
Loa Loa (eye worm) hypothetical protein 0.0136 0.0632 0.0633
Echinococcus granulosus acetylcholinesterase 0.0268 0.1349 0.1369
Schistosoma mansoni hypothetical protein 0.0886 0.472 0.4834
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0047 0.0147 0.013
Echinococcus granulosus metabotropic glutamate receptor 2 0.021 0.1032 0.1043
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0027 0.0036 0.0405
Brugia malayi Cytochrome P450 family protein 0.0034 0.0073 0.0058
Schistosoma mansoni cellular tumor antigen P53 0.0056 0.0193 0.0181
Onchocerca volvulus 0.0047 0.0147 0.2109
Trypanosoma cruzi DNA repair protein, putative 0.0057 0.0198 0.0975
Schistosoma mansoni adenoreceptor 0.0047 0.0147 0.0133
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0047 0.0147 0.013
Echinococcus multilocularis rhodopsin orphan GPCR 0.0047 0.0147 0.013
Loa Loa (eye worm) hypothetical protein 0.0027 0.0038 0.0022
Plasmodium vivax replication factor C subunit 1, putative 0.004 0.0104 0.0786
Loa Loa (eye worm) thioredoxin reductase 0.0053 0.0176 0.0163
Loa Loa (eye worm) hypothetical protein 0.0047 0.0147 0.0133
Echinococcus granulosus poly (ADP ribose) polymerase 0.0067 0.0256 0.0246
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.004 0.0104 0.1182
Loa Loa (eye worm) hypothetical protein 0.0047 0.0147 0.0133
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0054 0.0182 0.2072
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0045 0.0136 0.0402
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0042 0.0117 0.1329
Loa Loa (eye worm) jmjC domain-containing protein 0.0027 0.0038 0.0022
Echinococcus multilocularis beta LACTamase domain containing family member 0.0078 0.0314 0.0298
Schistosoma mansoni hypothetical protein 0.0093 0.0396 0.039
Mycobacterium leprae NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) 0.0182 0.088 1
Loa Loa (eye worm) neuropeptide F receptor 0.0047 0.0147 0.0133
Echinococcus granulosus replication factor c subunit 1 0.004 0.0104 0.009
Loa Loa (eye worm) CXXC zinc finger family protein 0.0062 0.0228 0.0217
Onchocerca volvulus 0.0045 0.0135 0.1924
Entamoeba histolytica hypothetical protein 0.0032 0.0064 0.0211
Plasmodium vivax acyl-CoA synthetase, putative 0.0041 0.0109 0.0851
Echinococcus multilocularis g protein coupled receptor 0.0047 0.0147 0.013
Loa Loa (eye worm) hypothetical protein 0.0054 0.0184 0.0172
Echinococcus granulosus rhodopsin orphan GPCR 0.0047 0.0147 0.0133
Echinococcus multilocularis Niemann Pick C1 protein 0.0322 0.1643 0.1629
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0047 0.0147 0.0133
Mycobacterium tuberculosis Probable hydrolase 0.0078 0.0314 0.1
Echinococcus multilocularis acetylcholinesterase 0.0268 0.1349 0.1334
Entamoeba histolytica acyl-coA synthetase, putative 0.0054 0.0184 0.0747
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0054 0.0182 0.2072
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.004 0.0104 0.009
Onchocerca volvulus 0.0028 0.0039 0.0363
Loa Loa (eye worm) TAR-binding protein 0.0136 0.0628 0.0628
Loa Loa (eye worm) hypothetical protein 0.0047 0.0147 0.0133
Onchocerca volvulus 0.0054 0.0184 0.2718
Leishmania major 4-coumarate:coa ligase-like protein 0.0054 0.0184 0.0902
Mycobacterium tuberculosis Carboxylesterase LipT 0.0045 0.0135 0.0298
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0045 0.0136 0.0402
Schistosoma mansoni growth hormone secretagogue receptor 0.0047 0.0147 0.0133
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0041 0.0109 0.007
Loa Loa (eye worm) hypothetical protein 0.0052 0.017 0.0157
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0047 0.0147 0.013
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.0054 0.0182 0.0166
Loa Loa (eye worm) hypothetical protein 0.004 0.0104 0.009
Loa Loa (eye worm) fli-1 protein 0.0232 0.1151 0.1165
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0064 0.0729
Mycobacterium tuberculosis Conserved protein 0.0078 0.0314 0.1
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0045 0.0135 0.0122
Echinococcus granulosus orexin receptor type 2 0.0047 0.0147 0.0133
Echinococcus granulosus survival motor neuron protein 1 0.0274 0.1381 0.1402
Onchocerca volvulus 0.0047 0.0147 0.2109
Loa Loa (eye worm) carboxylesterase 0.0045 0.0135 0.0122
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0045 0.0136 0.1541
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0038 0.0097 0.0149
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0054 0.0182 0.0892
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0078 0.0314 0.0305
Loa Loa (eye worm) hypothetical protein 0.0047 0.0147 0.0133
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0047 0.0147 0.0133
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0054 0.0182 0.2072
Loa Loa (eye worm) hypothetical protein 0.0047 0.0147 0.0133
Mycobacterium tuberculosis NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) 0.0182 0.088 0.3223
Schistosoma mansoni hypothetical protein 0.0042 0.0119 0.0105
Loa Loa (eye worm) hypothetical protein 0.0047 0.0147 0.0133
Treponema pallidum DNA ligase (lig) 0.004 0.0104 0.5
Echinococcus multilocularis neuropeptides capa receptor 0.0047 0.0147 0.013
Schistosoma mansoni opsin-like receptor 0.0047 0.0147 0.0133
Echinococcus granulosus neuropeptide Y receptor 0.0047 0.0147 0.0133
Loa Loa (eye worm) jmjC domain-containing protein 0.0027 0.0038 0.0022
Onchocerca volvulus 0.0047 0.0147 0.2109
Brugia malayi CXXC zinc finger family protein 0.0062 0.0228 0.0217
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0112 0.05 0.0484
Echinococcus multilocularis rhodopsin orphan GPCR 0.0047 0.0147 0.013
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0047 0.0147 0.0133
Echinococcus multilocularis phd:f box containing protein 0.0027 0.0038 0.0021
Loa Loa (eye worm) hypothetical protein 0.0045 0.0136 0.0122
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0047 0.0147 0.013
Entamoeba histolytica hypothetical protein 0.0082 0.0337 0.143
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0034 0.0073 0.0165
Brugia malayi neuropeptide F receptor 0.0047 0.0147 0.0133
Leishmania major C-8 sterol isomerase-like protein 0.0364 0.1872 1
Onchocerca volvulus Neuropeptide F receptor homolog 0.0047 0.0147 0.2109
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0064 0.0729
Echinococcus multilocularis metabotropic glutamate receptor 5 0.0308 0.1568 0.1554
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0135 0.0118
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0097 0.0415 0.041
Entamoeba histolytica hypothetical protein 0.0082 0.0337 0.143
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0059 0.0668
Loa Loa (eye worm) glutathione reductase 0.0053 0.0176 0.0163
Toxoplasma gondii ABC1 family protein 0.0078 0.0314 0.1134
Echinococcus granulosus muscleblind protein 0.0166 0.0796 0.08
Brugia malayi TAR-binding protein 0.0136 0.0628 0.0628
Echinococcus multilocularis g protein coupled receptor 0.0047 0.0147 0.013
Brugia malayi hypothetical protein 0.0047 0.0147 0.0133
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0031 0.0057 0.0041
Echinococcus granulosus caspase 8 0.0045 0.0136 0.0122
Plasmodium vivax hypothetical protein, conserved 0.0033 0.0068 0.036
Echinococcus multilocularis dro:myosuppressin receptor 0.0047 0.0147 0.013
Loa Loa (eye worm) hypothetical protein 0.0166 0.0796 0.08
Onchocerca volvulus 0.0078 0.0314 0.4824
Loa Loa (eye worm) cytochrome P450 family protein 0.0037 0.0088 0.0073
Leishmania major metacaspase, putative 0.0045 0.0136 0.064
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0054 0.0182 0.2072
Mycobacterium tuberculosis Probable reductase 0.012 0.0543 0.1901
Brugia malayi DKFZp564C0469 protein 0.004 0.0104 0.009
Loa Loa (eye worm) hypothetical protein 0.0186 0.0902 0.091
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0059 0.0668
Entamoeba histolytica hypothetical protein 0.004 0.0104 0.0389
Mycobacterium ulcerans enoyl-(acyl carrier protein) reductase 0.0182 0.088 1
Brugia malayi Protein kinase domain containing protein 0.0093 0.0398 0.0392
Loa Loa (eye worm) hypothetical protein 0.0293 0.1484 0.1508
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0047 0.0147 0.0133
Brugia malayi AMP-binding enzyme family protein 0.0054 0.0184 0.0172
Toxoplasma gondii hypothetical protein 0.0039 0.0101 0.0258
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0104 0.1182
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0038 0.0097 0.0149
Loa Loa (eye worm) hypothetical protein 0.0088 0.0366 0.0359
Leishmania major 4-coumarate:coa ligase-like protein 0.0054 0.0184 0.0902
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0135 0.0121
Echinococcus granulosus rhodopsin orphan GPCR 0.0047 0.0147 0.0133
Schistosoma mansoni amine GPCR 0.0047 0.0147 0.0133
Trypanosoma cruzi Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region/Zinc-finger (CX5CX6HX5H) motif containing protein, putative 0.0057 0.0198 0.0975
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0047 0.0147 0.013
Schistosoma mansoni serine/threonine protein kinase 0.0112 0.05 0.0497
Schistosoma mansoni subfamily C14A unassigned peptidase (C14 family) 0.0045 0.0136 0.0122
Echinococcus granulosus lysine specific demethylase 5A 0.0106 0.0468 0.0463
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0047 0.0147 0.0133
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0047 0.0147 0.013
Mycobacterium leprae PROBABLE DNA LIGASE [NAD DEPENDENT] LIGA (POLYDEOXYRIBONUCLEOTIDE SYNTHASE [NAD+]) 0.004 0.0104 0.0044
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0054 0.0182 0.0788
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0042 0.0117 0.0325
Echinococcus multilocularis rhodopsin orphan GPCR 0.0047 0.0147 0.013
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0054 0.0182 0.2072
Loa Loa (eye worm) hypothetical protein 0.0047 0.0147 0.0133
Schistosoma mansoni poly [ADP-ribose] polymerase 0.0206 0.1014 0.1025
Brugia malayi Serotonin receptor 0.0047 0.0147 0.0133
Schistosoma mansoni neuropeptide f receptor 76f 0.0047 0.0147 0.0133
Toxoplasma gondii ATPase, AAA family protein 0.004 0.0104 0.0272
Brugia malayi hypothetical protein 0.0047 0.0147 0.0133
Brugia malayi CHE-14 protein 0.0097 0.0415 0.041
Onchocerca volvulus 0.004 0.0104 0.1416
Echinococcus granulosus neuropeptide receptor 0.0047 0.0147 0.0133
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0054 0.0182 0.2072
Echinococcus granulosus fmrfamide receptor 0.0047 0.0147 0.0133
Schistosoma mansoni phd/f-box containing protein 0.0027 0.0038 0.0022
Brugia malayi Melatonin receptor type 1A 0.0047 0.0147 0.0133
Schistosoma mansoni jumonji/arid domain-containing protein 0.0106 0.0468 0.0463
Mycobacterium tuberculosis Probable esterase LipL 0.0078 0.0314 0.1
Schistosoma mansoni amine GPCR 0.0047 0.0147 0.0133
Leishmania major hypothetical protein, conserved 0.0057 0.0198 0.0975
Brugia malayi ERG2 and Sigma1 receptor like protein 0.0364 0.1872 0.1906
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0136 0.1541
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0047 0.0147 0.0133
Giardia lamblia Histone acetyltransferase GCN5 0.0038 0.0098 0.069
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0054 0.0184 0.1072
Echinococcus multilocularis G-protein coupled receptor, putative 0.0047 0.0147 0.013
Echinococcus multilocularis microtubule associated protein 2 0.0737 0.3906 0.3895
Echinococcus granulosus jumonji domain containing protein 0.0046 0.0138 0.0125
Onchocerca volvulus 0.0045 0.0135 0.1924
Entamoeba histolytica hypothetical protein 0.0082 0.0337 0.143
Echinococcus multilocularis allatostatin A receptor 0.0047 0.0147 0.013
Echinococcus multilocularis muscleblind protein 0.0166 0.0796 0.078
Onchocerca volvulus 0.0047 0.0147 0.2109
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.0039 0.0023
Schistosoma mansoni hypothetical protein 0.0052 0.017 0.0157
Brugia malayi Muscleblind-like protein 0.0166 0.0796 0.08
Trypanosoma brucei metacaspase 0.0045 0.0136 0.0533
Echinococcus granulosus allatostatin A receptor 0.0047 0.0147 0.0133
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0045 0.0136 0.1541
Brugia malayi Tachykinin-like peptides receptor 99D 0.0047 0.0147 0.0133
Echinococcus multilocularis para nitrobenzyl esterase 0.0045 0.0135 0.0119
Loa Loa (eye worm) hypothetical protein 0.0047 0.0147 0.0133
Trypanosoma brucei cytochrome P450, putative 0.0034 0.0073 0.0191
Echinococcus granulosus caspase 0.012 0.0542 0.054
Brugia malayi Carboxylesterase family protein 0.0045 0.0135 0.0122
Loa Loa (eye worm) hypothetical protein 0.0047 0.0147 0.0133
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0054 0.0184 0.1521
Trypanosoma cruzi poly(ADP-ribose) polymerase, putative 0.0239 0.119 0.6322
Loa Loa (eye worm) hypothetical protein 0.0047 0.0147 0.0133
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0042 0.0117 0.094
Trypanosoma cruzi cytochrome P450, putative 0.0034 0.0073 0.0302
Schistosoma mansoni hypothetical protein 0.0041 0.011 0.0096
Brugia malayi hypothetical protein 0.0082 0.0337 0.0329
Onchocerca volvulus Poor gastrulation protein homolog 0.0041 0.011 0.1513
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0038 0.0097 0.0149
Brugia malayi AMP-binding enzyme family protein 0.0054 0.0184 0.0172
Brugia malayi G-protein coupled receptor 0.0047 0.0147 0.0133
Loa Loa (eye worm) G-protein coupled receptor 0.0047 0.0147 0.0133
Loa Loa (eye worm) cytochrome P450 family protein 0.0034 0.0073 0.0058
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.004 0.0104 0.0389
Schistosoma mansoni kinase 0.006 0.0214 0.0203
Onchocerca volvulus Cell death protein 3 homolog 0.0088 0.0366 0.5667
Mycobacterium tuberculosis Probable lipase LipD 0.0078 0.0314 0.1
Loa Loa (eye worm) hypothetical protein 0.0047 0.0147 0.0133
Loa Loa (eye worm) hypothetical protein 0.0078 0.0314 0.0305
Brugia malayi Dopamine receptor protein 2 0.0047 0.0147 0.0133
Echinococcus multilocularis chromobox protein 1 0.0079 0.0318 0.0301
Loa Loa (eye worm) hypothetical protein 0.0047 0.0147 0.0133
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0027 0.0038 0.0022
Trichomonas vaginalis chromobox protein, putative 0.0047 0.0147 0.1674
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0171 0.0819 0.0824
Trypanosoma cruzi C-8 sterol isomerase, putative 0.0364 0.1872 1
Schistosoma mansoni gliotactin 0.0045 0.0135 0.0122
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0045 0.0135 0.0122
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0054 0.0182 0.2072
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0052 0.017 0.0157
Brugia malayi hypothetical protein 0.004 0.0104 0.009
Trypanosoma brucei trypanothione reductase 0.0053 0.0176 0.0752
Echinococcus multilocularis protein dispatched 1 0.011 0.049 0.0474
Onchocerca volvulus 0.0028 0.0039 0.0363
Schistosoma mansoni biogenic amine (5HT) receptor 0.0293 0.1484 0.1508
Echinococcus multilocularis caspase 3 0.0075 0.0295 0.0278
Plasmodium falciparum metacaspase 1 0.0045 0.0136 0.1161
Entamoeba histolytica protein kinase, putative 0.0093 0.0398 0.1702
Loa Loa (eye worm) hypothetical protein 0.0045 0.0135 0.0122
Loa Loa (eye worm) hypothetical protein 0.0293 0.1484 0.1508
Echinococcus granulosus carboxylesterase 5A 0.0268 0.1349 0.1369
Brugia malayi jmjC domain containing protein 0.0027 0.0038 0.0022
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0225 0.1116 0.4908
Loa Loa (eye worm) hypothetical protein 0.0064 0.0238 0.0228
Echinococcus granulosus tm gpcr rhodopsin 0.0047 0.0147 0.0133
Brugia malayi acetyltransferase, GNAT family protein 0.0142 0.0665 0.0666
Onchocerca volvulus 0.0045 0.0135 0.1924
Leishmania major hypothetical protein, conserved 0.0078 0.0314 0.1601
Schistosoma mansoni biogenic amine receptor 0.0047 0.0147 0.0133
Loa Loa (eye worm) hypothetical protein 0.0054 0.0184 0.0172
Echinococcus multilocularis poly (ADP ribose) polymerase 1 0.0434 0.2257 0.2244
Echinococcus granulosus poly (ADP ribose) polymerase 0.0135 0.0624 0.0624
Loa Loa (eye worm) hypothetical protein 0.0041 0.0109 0.0095
Echinococcus multilocularis neuropeptide s receptor 0.0047 0.0147 0.013
Mycobacterium ulcerans NAD-dependent DNA ligase LigA 0.004 0.0104 0.0544
Entamoeba histolytica acetyltransferase, GNAT family 0.0038 0.0098 0.0362
Brugia malayi PHD-finger family protein 0.0033 0.0068 0.0053
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0047 0.0147 0.0133
Trypanosoma cruzi cytochrome P450, putative 0.0034 0.0073 0.0302
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0054 0.0182 0.0892
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0045 0.0135 0.1538
Brugia malayi hypothetical protein 0.0047 0.0147 0.0133
Brugia malayi hypothetical protein 0.0047 0.0147 0.0133
Echinococcus multilocularis fmrfamide receptor 0.0047 0.0147 0.013
Schistosoma mansoni tar DNA-binding protein 0.0136 0.0628 0.0628
Leishmania major pteridine reductase 1 0.0031 0.0059 0.0229
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0044 0.0129 0.1823
Mycobacterium ulcerans esterase/lipase LipP 0.0078 0.0314 0.3101
Loa Loa (eye worm) hypothetical protein 0.0027 0.0036 0.002
Echinococcus granulosus peregrin 0.0036 0.0087 0.0072
Echinococcus granulosus acetylcholinesterase 0.0268 0.1349 0.1369
Schistosoma mansoni biogenic amine (5HT) receptor 0.0047 0.0147 0.0133
Echinococcus multilocularis MAP kinase activated protein kinase 2 0.1808 0.9747 0.9747
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0101 0.1143
Brugia malayi glutathione reductase 0.0053 0.0176 0.0163
Echinococcus granulosus JmjC domain containing protein 4 0.0027 0.0038 0.0022
Schistosoma mansoni intermediate filament proteins 0.0028 0.0039 0.0023
Brugia malayi jmjC domain containing protein 0.0027 0.0038 0.0022
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0027 0.0038 0.0113
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0112 0.05 0.0497
Echinococcus granulosus neuropeptides capa receptor 0.0047 0.0147 0.0133
Echinococcus multilocularis JmjC domain containing protein 4 0.0027 0.0038 0.0021
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.0228 0.2052
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0045 0.0135 0.0122
Brugia malayi hypothetical protein 0.0047 0.0147 0.0133
Loa Loa (eye worm) hypothetical protein 0.0047 0.0147 0.0133
Loa Loa (eye worm) latrophilin receptor protein 2 0.0052 0.017 0.0157
Schistosoma mansoni gabp alpha 0.0076 0.0304 0.0295
Loa Loa (eye worm) hypothetical protein 0.0047 0.0147 0.0133
Echinococcus granulosus 7TM GPCR rhodopsin 0.0047 0.0147 0.0133
Schistosoma mansoni hypothetical protein 0.0093 0.0396 0.039
Echinococcus granulosus chromobox protein 1 0.0079 0.0318 0.0309
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.012 0.0543 0.1901
Loa Loa (eye worm) hypothetical protein 0.0027 0.0038 0.0022
Trichomonas vaginalis conserved hypothetical protein 0.0097 0.0415 0.472
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0047 0.0147 0.0133
Brugia malayi metabotropic glutamate receptor type 2 0.0122 0.0554 0.0552
Onchocerca volvulus 0.0035 0.0077 0.0979
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0054 0.0182 0.2072
Giardia lamblia Replication factor C, subunit 1 0.004 0.0104 0.0831
Brugia malayi GnHR receptor homolog 0.0047 0.0147 0.0133
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0054 0.0184 0.1521
Trypanosoma brucei hypothetical protein, conserved 0.0078 0.0314 0.1505
Echinococcus granulosus intermediate filament protein 0.0028 0.0039 0.0023
Loa Loa (eye worm) hypothetical protein 0.0047 0.0147 0.0133
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0054 0.0182 0.2072
Toxoplasma gondii hypothetical protein 0.0039 0.0101 0.0258
Onchocerca volvulus 0.0047 0.0147 0.2109
Echinococcus granulosus dnaJ subfamily B 0.0886 0.472 0.4834
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0052 0.017 0.0157
Brugia malayi RNA recognition motif domain containing protein 0.0136 0.0628 0.0628
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0047 0.0147 0.0133
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.0479 0.2498 0.2486
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0053 0.0176 0.0457
Leishmania major 4-coumarate:coa ligase-like protein 0.0054 0.0184 0.0902
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0047 0.0147 0.0133
Loa Loa (eye worm) hypothetical protein 0.0047 0.0147 0.0133
Loa Loa (eye worm) hypothetical protein 0.0041 0.0109 0.0095
Echinococcus multilocularis rhodopsin orphan GPCR 0.0047 0.0147 0.013
Entamoeba histolytica hypothetical protein 0.0032 0.0064 0.0211
Loa Loa (eye worm) hypothetical protein 0.0331 0.1691 0.1721
Echinococcus granulosus lamin dm0 0.0028 0.0039 0.0023
Echinococcus multilocularis g protein coupled receptor 0.0047 0.0147 0.013
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0076 0.0304 0.0295
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0093 0.0398 0.2055
Brugia malayi map kinase activated protein kinase protein 2 0.1808 0.9747 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0047 0.0147 0.013
Brugia malayi Heterochromatin protein 1 0.0079 0.0318 0.0309
Schistosoma mansoni neuropeptide receptor 0.0047 0.0147 0.0133
Plasmodium vivax thioredoxin reductase, putative 0.0053 0.0176 0.1637
Toxoplasma gondii PHD-finger domain-containing protein 0.0033 0.0068 0.0124
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.0054 0.0182 0.017
Echinococcus granulosus GA binding protein alpha chain 0.0076 0.0304 0.0295
Schistosoma mansoni acetylcholinesterase 0.0045 0.0135 0.0122
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0047 0.0147 0.013
Schistosoma mansoni jumonji domain containing protein 0.0149 0.0698 0.07
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0027 0.0038 0.0113
Loa Loa (eye worm) hypothetical protein 0.0047 0.0147 0.0133
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0047 0.0147 0.0133
Trichomonas vaginalis esterase, putative 0.0078 0.0314 0.3566
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0104 0.1182
Loa Loa (eye worm) PHD-finger family protein 0.0033 0.0068 0.0053
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.0054 0.0182 0.2072
Onchocerca volvulus Metabotropic glutamate receptor homolog 0.0041 0.011 0.1513
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0082 0.0337 0.0321
Trypanosoma cruzi hypothetical protein, conserved 0.0078 0.0314 0.1601
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0064 0.0729
Loa Loa (eye worm) hypothetical protein 0.0047 0.0147 0.0133
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0136 0.1541
Echinococcus multilocularis somatostatin receptor 0.0047 0.0147 0.013
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0045 0.0136 0.1541
Schistosoma mansoni caspase-3 (C14 family) 0.012 0.0542 0.054
Schistosoma mansoni tankyrase 0.0032 0.0064 0.0049
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0047 0.0147 0.0133
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0163 0.0778 0.0782
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0027 0.0036 0.0405
Echinococcus granulosus dro:myosuppressin receptor 0.0047 0.0147 0.0133
Echinococcus granulosus alpha 1A adrenergic receptor 0.0047 0.0147 0.0133
Trichomonas vaginalis CAMK family protein kinase 0.0112 0.05 0.5686
Entamoeba histolytica poly(ADP-ribose) polymerase, putative 0.0434 0.2257 1
Trichomonas vaginalis CAMK family protein kinase 0.0112 0.05 0.5686
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0041 0.0109 0.0611
Onchocerca volvulus 0.0062 0.0228 0.3427
Brugia malayi beta-lactamase family protein 0.0078 0.0314 0.0305
Loa Loa (eye worm) hypothetical protein 0.004 0.0104 0.009
Echinococcus granulosus caspase 3 0.0075 0.0295 0.0286
Echinococcus granulosus thioredoxin glutathione reductase 0.0053 0.0176 0.0163
Brugia malayi hypothetical protein 0.004 0.0104 0.009
Schistosoma mansoni neuropeptide receptor 0.0047 0.0147 0.0133
Loa Loa (eye worm) hypothetical protein 0.0028 0.0039 0.0023
Echinococcus granulosus dual specificity 0.0093 0.0398 0.0392
Loa Loa (eye worm) hypothetical protein 0.0041 0.0109 0.0095
Plasmodium falciparum replication factor C subunit 1, putative 0.004 0.0104 0.0786
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0047 0.0147 0.0133
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0498 0.2606 1
Brugia malayi Pax transcription activation domain interacting protein 0.004 0.0104 0.009
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0047 0.0147 0.0133
Loa Loa (eye worm) carboxylesterase 0.0045 0.0135 0.0122
Brugia malayi ORL1-like opioid receptor 0.0047 0.0147 0.0133
Echinococcus multilocularis GPCR, family 2 0.0052 0.017 0.0153
Trypanosoma cruzi hypothetical protein, conserved 0.0078 0.0314 0.1601
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0054 0.0182 0.2072
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0052 0.017 0.0153
Brugia malayi Bromodomain containing protein 0.0036 0.0087 0.0072
Schistosoma mansoni neuropeptide F-like receptor 0.0047 0.0147 0.0133
Schistosoma mansoni cpg binding protein 0.0066 0.0247 0.0237
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0045 0.0136 0.1541
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0045 0.0135 0.0298
Schistosoma mansoni hypothetical protein 0.0056 0.0193 0.0181
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0054 0.0182 0.017
Entamoeba histolytica hypothetical protein 0.0093 0.0398 0.1702
Mycobacterium leprae conserved hypothetical protein 0.0078 0.0314 0.2736
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0078 0.0314 0.0305
Echinococcus granulosus biogenic amine 5HT receptor 0.0047 0.0147 0.0133
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.004 0.0104 0.1182
Schistosoma mansoni jumonji/arid domain-containing protein 0.0106 0.0468 0.0463
Echinococcus multilocularis neuropeptide FF receptor 2 0.0047 0.0147 0.013
Trichomonas vaginalis replication factor C large subunit, putative 0.004 0.0104 0.1182
Mycobacterium tuberculosis Two component sensor histidine kinase DosT 0.0039 0.0101 0.0162
Loa Loa (eye worm) TYRA-2 protein 0.0047 0.0147 0.0133
Entamoeba histolytica hypothetical protein 0.0032 0.0064 0.0211
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0047 0.0147 0.013
Trypanosoma brucei C-8 sterol isomerase, putative 0.0364 0.1872 1
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0054 0.0184 0.1521
Schistosoma mansoni biogenic amine receptor 0.0047 0.0147 0.0133
Brugia malayi hypothetical protein 0.0274 0.1381 0.1402
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0136 0.0628 0.0628
Echinococcus multilocularis rhodopsin orphan GPCR 0.0047 0.0147 0.013
Schistosoma mansoni lamin 0.0028 0.0039 0.0023
Brugia malayi RE15519p 0.0047 0.0147 0.0133
Loa Loa (eye worm) hypothetical protein 0.0045 0.0135 0.0122
Echinococcus multilocularis GPCR, family 3, C terminal 0.0041 0.011 0.0093
Onchocerca volvulus 0.0047 0.0147 0.2109
Echinococcus granulosus peptide allatostatin:somatostatin 0.0047 0.0147 0.0133
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0129 0.1466
Schistosoma mansoni cpg binding protein 0.0062 0.0228 0.0217
Echinococcus multilocularis serotonin receptor 0.0293 0.1484 0.147
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0064 0.0729
Echinococcus multilocularis geminin 0.0346 0.1773 0.1759
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0047 0.0147 0.0133
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0047 0.0147 0.013
Echinococcus granulosus tankyrase 0.0032 0.0064 0.0049
Schistosoma mansoni amine GPCR 0.0047 0.0147 0.0133
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0054 0.0182 0.2072
Loa Loa (eye worm) CYP4Cod1 0.0034 0.0073 0.0058
Trichomonas vaginalis chromobox protein, putative 0.0079 0.0318 0.3609
Echinococcus multilocularis tankyrase 0.0032 0.0064 0.0047
Brugia malayi Receptor family ligand binding region containing protein 0.0064 0.0238 0.0228
Toxoplasma gondii GAF domain-containing protein 0.0039 0.0101 0.0258
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0045 0.0136 0.1541
Loa Loa (eye worm) hypothetical protein 0.0045 0.0135 0.0122
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0104 0.1182
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0027 0.0036 0.0405
Trypanosoma brucei oxidoreductase-like protein 0.0031 0.0059 0.0117
Brugia malayi sulfakinin receptor protein 0.0047 0.0147 0.0133
Echinococcus multilocularis jumonji domain containing 1A 0.0027 0.0038 0.0021
Loa Loa (eye worm) hypothetical protein 0.0239 0.119 0.1205
Loa Loa (eye worm) hypothetical protein 0.0047 0.0147 0.0133
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0047 0.0147 0.0133
Toxoplasma gondii enoyl-acyl carrier reductase ENR 0.0182 0.088 0.346
Loa Loa (eye worm) hypothetical protein 0.0057 0.0198 0.0186
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0047 0.0147 0.013
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0136 0.1541
Brugia malayi G protein-coupled receptor F59B2.13 0.0047 0.0147 0.0133
Onchocerca volvulus 0.0047 0.0147 0.2109
Brugia malayi Latrophilin receptor protein 2 0.0052 0.017 0.0157
Loa Loa (eye worm) hypothetical protein 0.004 0.0104 0.009
Echinococcus granulosus tar DNA binding protein 0.0136 0.0628 0.0628
Brugia malayi beta-lactamase 0.0078 0.0314 0.0305
Echinococcus multilocularis lamin dm0 0.0028 0.0039 0.0022
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0135 0.0121
Schistosoma mansoni metabotropic glutamate receptor 2 3 (mglur group 2) 0.0285 0.144 0.1463
Onchocerca volvulus 0.0047 0.0147 0.2109
Mycobacterium ulcerans acyl-CoA synthetase 0.0054 0.0184 0.1521
Brugia malayi AKH receptor 0.0047 0.0147 0.0133
Loa Loa (eye worm) hypothetical protein 0.0047 0.0147 0.0133
Onchocerca volvulus 0.0031 0.0059 0.069
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0054 0.0182 0.2072
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0062 0.0228 0.0211
Loa Loa (eye worm) RNA binding protein 0.0136 0.0628 0.0628
Mycobacterium ulcerans two component sensor histidine kinase DevS 0.0039 0.0101 0.0503
Brugia malayi Serotonin receptor 0.0499 0.2607 0.2662
Loa Loa (eye worm) hypothetical protein 0.0268 0.1349 0.1369
Loa Loa (eye worm) hypothetical protein 0.0047 0.0147 0.0133
Plasmodium vivax enoyl-acyl carrier protein reductase 0.0182 0.088 1
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.004 0.0104 0.1182
Mycobacterium ulcerans putative regulatory protein 0.0039 0.0101 0.0503
Echinococcus granulosus tachykinin peptides receptor 99D 0.0047 0.0147 0.0133
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0052 0.017 0.0157
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0033 0.0068 0.0053
Brugia malayi Carboxylesterase family protein 0.0045 0.0135 0.0122
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0136 0.1541
Brugia malayi putative neuropeptide receptor NPR1 0.0047 0.0147 0.0133
Loa Loa (eye worm) hypothetical protein 0.0047 0.0147 0.0133
Entamoeba histolytica protein kinase domain containing protein 0.0093 0.0398 0.1702
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0062 0.0228 0.1137
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0054 0.0184 0.049
Loa Loa (eye worm) hypothetical protein 0.0047 0.0147 0.0133
Schistosoma mansoni patched 1 0.0097 0.0415 0.041
Loa Loa (eye worm) hypothetical protein 0.0047 0.0147 0.0133
Echinococcus multilocularis dual specificity 0.0093 0.0398 0.0382
Trichomonas vaginalis spcc417.12 protein, putative 0.0045 0.0135 0.1538
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0054 0.0182 0.2072
Toxoplasma gondii PHD-finger domain-containing protein 0.0033 0.0068 0.0124
Mycobacterium tuberculosis Conserved protein 0.0078 0.0314 0.1
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0054 0.0182 0.0892
Trichomonas vaginalis CAMK family protein kinase 0.0058 0.0207 0.2348
Echinococcus granulosus 7tm_1 domain containing protein 0.0047 0.0147 0.0133
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0054 0.0182 0.2072
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0112 0.05 0.2607
Mycobacterium ulcerans lipase LipD 0.0078 0.0314 0.3101
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0135 0.0118
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0047 0.0147 0.0133
Echinococcus multilocularis dnaJ subfamily B 0.0886 0.472 0.4711
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0047 0.0147 0.0133
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0054 0.0182 0.2072
Brugia malayi Carboxylesterase family protein 0.0045 0.0135 0.0122
Echinococcus multilocularis neuropeptide receptor 0.0047 0.0147 0.013
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0135 0.0121
Echinococcus granulosus poly (ADP ribose) polymerase 0.0067 0.0256 0.0246
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0062 0.0228 0.0661
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0047 0.0147 0.013
Trypanosoma cruzi polo-like protein kinase, putative 0.0112 0.05 0.2607
Echinococcus multilocularis muscleblind protein 1 0.0166 0.0796 0.078
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0045 0.0135 0.0298
Schistosoma mansoni caspase-7 (C14 family) 0.012 0.0542 0.054
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0104 0.047
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0045 0.0135 0.0122
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0047 0.0147 0.0133
Loa Loa (eye worm) intermediate filament protein 0.0028 0.0039 0.0023
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0134 0.0617 0.2188
Loa Loa (eye worm) hypothetical protein 0.0047 0.0147 0.0133
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0047 0.0147 0.2119
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0054 0.0182 0.0788
Echinococcus multilocularis caspase 2 0.0088 0.0366 0.0349
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.0474 0.2472 1
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0047 0.0147 0.0133
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0047 0.0147 0.0133
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0054 0.0182 0.2072
Echinococcus multilocularis tar DNA binding protein 0.0136 0.0628 0.0612
Brugia malayi Dopamine receptor protein 1 0.0047 0.0147 0.0133
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.0093 0.0398 0.1964
Toxoplasma gondii histone lysine methyltransferase SET1 0.0121 0.055 0.2105
Entamoeba histolytica acyl-CoA synthetase, putative 0.0054 0.0184 0.0747
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0064 0.0729
Echinococcus granulosus poly ADP ribose polymerase 1 0.0434 0.2257 0.2302
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0038 0.0097 0.0149
Loa Loa (eye worm) hypothetical protein 0.004 0.0104 0.009
Loa Loa (eye worm) hypothetical protein 0.0045 0.0135 0.0122
Brugia malayi F/Y-rich N-terminus family protein 0.003 0.0051 0.0035
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0064 0.0729
Toxoplasma gondii 2,4-dienoyl CoA reductase 2, peroxisomal family protein 0.0031 0.0059 0.0088
Chlamydia trachomatis enoyl-acyl-carrier protein reductase 0.0182 0.088 1
Echinococcus multilocularis tumor protein p63 0.0382 0.1969 0.1956
Loa Loa (eye worm) hypothetical protein 0.0308 0.1568 0.1595
Trypanosoma brucei metacaspase MCA3 0.0045 0.0136 0.0533
Schistosoma mansoni poly [ADP-ribose] polymerase 0.0239 0.119 0.1205
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0047 0.0147 0.013
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0101 0.1143
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0163 0.0778 0.0782
Loa Loa (eye worm) melatonin receptor type 1A 0.0047 0.0147 0.0133
Trypanosoma cruzi poly(ADP-ribose) polymerase, putative 0.0239 0.119 0.6322
Brugia malayi jmjC domain containing protein 0.0171 0.0819 0.0824
Schistosoma mansoni amine GPCR 0.0047 0.0147 0.0133
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0078 0.0314 0.1
Loa Loa (eye worm) hypothetical protein 0.0078 0.0314 0.0305
Brugia malayi Cell death protein 3 precursor 0.0088 0.0366 0.0359
Brugia malayi hypothetical protein 0.0047 0.0147 0.0133
Mycobacterium ulcerans carboxylesterase, LipT 0.0045 0.0135 0.0926
Onchocerca volvulus 0.0078 0.0314 0.4824
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0054 0.0184 0.1072
Mycobacterium ulcerans hypothetical protein 0.0078 0.0314 0.3101
Trypanosoma brucei metacaspase MCA2 0.0045 0.0136 0.0533
Echinococcus granulosus poly adp ribose polymerase 2 0.0239 0.119 0.1205
Entamoeba histolytica hypothetical protein 0.0032 0.0064 0.0211
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0078 0.0314 0.0305
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0054 0.0182 0.2072
Schistosoma mansoni aldehyde dehydrogenase 0.0062 0.0228 0.0217
Echinococcus multilocularis rhodopsin orphan GPCR 0.0047 0.0147 0.013
Schistosoma mansoni phosphatidylserine receptor 0.0027 0.0038 0.0022
Brugia malayi Cytochrome P450 family protein 0.0034 0.0073 0.0058
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0047 0.0147 0.0133
Echinococcus granulosus para nitrobenzyl esterase 0.0045 0.0135 0.0122
Loa Loa (eye worm) carboxylesterase 0.0268 0.1349 0.1369
Loa Loa (eye worm) hypothetical protein 0.0054 0.0182 0.017
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0082 0.0337 0.0329
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0047 0.0147 0.0133
Trypanosoma brucei poly(adp-ribose) polymerase 0.0239 0.119 0.628
Echinococcus multilocularis fmrfamide receptor 0.0047 0.0147 0.013
Loa Loa (eye worm) receptor family ligand binding region containing protein 0.0064 0.0238 0.0228
Trichomonas vaginalis conserved hypothetical protein 0.0054 0.0182 0.2072
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0047 0.0147 0.0133
Echinococcus multilocularis replication factor c subunit 1 0.004 0.0104 0.0087
Echinococcus multilocularis neuropeptide receptor 0.0047 0.0147 0.013
Echinococcus multilocularis caspase 0.012 0.0542 0.0526
Brugia malayi topoisomerase 0.004 0.0104 0.009
Schistosoma mansoni serine/threonine protein kinase 0.0093 0.0398 0.0392
Brugia malayi RNA binding protein 0.0136 0.0628 0.0628
Echinococcus multilocularis PHD finger protein rhinoceros 0.0033 0.0068 0.0051
Trichomonas vaginalis penicillin-binding protein, putative 0.0078 0.0314 0.3566
Echinococcus multilocularis neuropeptide Y receptor 0.0047 0.0147 0.013
Brugia malayi larval opioid receptor 0.0047 0.0147 0.0133
Schistosoma mansoni chromobox protein 0.0079 0.0318 0.0309
Mycobacterium tuberculosis Probable lipase LipE 0.0078 0.0314 0.1
Brugia malayi Ets-domain containing protein 0.0076 0.0304 0.0295
Loa Loa (eye worm) hypothetical protein 0.0045 0.0135 0.0122
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0054 0.0182 0.2072
Trichomonas vaginalis CAMK family protein kinase 0.0112 0.05 0.5686
Onchocerca volvulus Alhambra homolog 0.0033 0.0068 0.0832
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0078 0.0314 0.3101
Schistosoma mansoni topbp1 0.004 0.0104 0.009
Brugia malayi Niemann-Pick C1 protein precursor 0.0225 0.1116 0.113
Loa Loa (eye worm) hypothetical protein 0.0042 0.0119 0.0105
Trichomonas vaginalis bromodomain-containing protein, putative 0.0042 0.0117 0.1329
Schistosoma mansoni DNA ligase IV 0.004 0.0104 0.009
Brugia malayi Carboxylesterase family protein 0.0268 0.1349 0.1369
Echinococcus granulosus hypothetical protein 0.0047 0.0147 0.0133
Brugia malayi Fli-1 protein 0.0232 0.1151 0.1165
Loa Loa (eye worm) tnks protein 0.0032 0.0064 0.0049
Loa Loa (eye worm) camk/mapkapk/mapkapk protein kinase 0.1808 0.9747 1
Echinococcus granulosus neuropeptide receptor A26 0.0047 0.0147 0.0133
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.0054 0.0182 0.017
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0129 0.1466
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.0479 0.2498 0.255
Loa Loa (eye worm) jmjC domain-containing protein 0.0068 0.0259 0.0249
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0093 0.0398 0.2055
Schistosoma mansoni chromobox protein 0.0079 0.0318 0.0309
Trichomonas vaginalis CAMK family protein kinase 0.0058 0.0207 0.2348
Brugia malayi hypothetical protein 0.0042 0.0119 0.0105
Onchocerca volvulus Tankyrase homolog 0.0032 0.0064 0.0768
Echinococcus multilocularis nibrin 0.004 0.0104 0.0087
Loa Loa (eye worm) poly(ADP-ribose) polymerase 0.0171 0.0822 0.0827
Loa Loa (eye worm) hypothetical protein 0.0225 0.1116 0.113
Echinococcus multilocularis neuropeptide receptor A26 0.0047 0.0147 0.013
Loa Loa (eye worm) hypothetical protein 0.004 0.0104 0.009
Onchocerca volvulus 0.0047 0.0147 0.2109
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0078 0.0314 0.1
Plasmodium falciparum glutathione reductase 0.0053 0.0176 0.1637
Brugia malayi G-protein coupled receptor 0.0047 0.0147 0.0133
Brugia malayi Cytochrome P450 family protein 0.0037 0.0088 0.0073
Trichomonas vaginalis CAMK family protein kinase 0.0112 0.05 0.5686
Entamoeba histolytica acyl-CoA synthetase, putative 0.0054 0.0184 0.0747
Leishmania major DNA repair protein, putative 0.0057 0.0198 0.0975
Wolbachia endosymbiont of Brugia malayi enoyl-ACP reductase 0.0182 0.088 1
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0054 0.0182 0.2072
Echinococcus granulosus Niemann Pick C1 protein 0.0322 0.1643 0.1671
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0045 0.0135 0.0119
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0045 0.0136 0.1541
Schistosoma mansoni transcription factor LCR-F1 0.0082 0.0337 0.0329
Brugia malayi Calcitonin receptor-like protein seb-1 0.0163 0.0778 0.0782
Echinococcus granulosus metabotropic glutamate receptor 5 0.0308 0.1568 0.1595
Entamoeba histolytica serine/threonine protein kinase, putative 0.0112 0.05 0.2159
Loa Loa (eye worm) hypothetical protein 0.0088 0.0366 0.0359
Echinococcus granulosus rhodopsin orphan GPCR 0.0047 0.0147 0.0133
Echinococcus granulosus sex peptide receptor 0.0047 0.0147 0.0133
Schistosoma mansoni biogenic amine receptor 0.0047 0.0147 0.0133
Entamoeba histolytica zinc finger protein, putative 0.0032 0.0064 0.0211
Schistosoma mansoni tar DNA-binding protein 0.0136 0.0628 0.0628
Plasmodium vivax hypothetical protein, conserved 0.0045 0.0136 0.1161

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 4.1475 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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