Detailed information for compound 1125090

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 502.683 | Formula: C30H46O6
  • H donors: 4 H acceptors: 6 LogP: 4.91 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 2
  • SMILES: C[C@@H]1CC[C@]2([C@@H]([C@H]1C)C1=CC[C@H]3[C@@]([C@@]1(CC2)C(=O)O)(C)CC[C@@H]1[C@]3(C)C[C@@H](O)[C@@H](C1(C)C)O)C(=O)O
  • InChi: 1S/C30H46O6/c1-16-9-12-29(24(33)34)13-14-30(25(35)36)18(22(29)17(16)2)7-8-21-27(5)15-19(31)23(32)26(3,4)20(27)10-11-28(21,30)6/h7,16-17,19-23,31-32H,8-15H2,1-6H3,(H,33,34)(H,35,36)/t16-,17+,19-,20+,21-,22+,23+,27+,28-,29+,30-/m1/s1
  • InChiKey: KVVOHEZJRCCRBF-VOFZAGMQSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Entamoeba histolytica acyl-CoA synthetase, putative 0.0048 0.0173 0.4292
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.0031 0.0489
Loa Loa (eye worm) hypothetical protein 0.0125 0.0493 0.0481
Schistosoma mansoni thyroid hormone receptor 0.001 0.0015 0.0002
Schistosoma mansoni cercarial elastase (S01 family) 0.0176 0.0707 0.0695
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.0176 0.0707 0.1151
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.0014 0.0031 0.0298
Toxoplasma gondii ATPase, AAA family protein 0.001 0.0013 0.0000020164
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0014 0.0031 0.0489
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0141 0.0563 0.0552
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0049 0.0177 0.0273
Onchocerca volvulus 0.0048 0.0174 0.0161
Loa Loa (eye worm) matrixin family protein 0.0301 0.1233 0.1221
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0032 0.0105 0.0093
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0014 0.0031 0.0031
Echinococcus multilocularis Niemann Pick C1 protein 0.0141 0.0562 0.0911
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0013 0.0025 0.0202
Onchocerca volvulus 0.0177 0.0711 0.0699
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0014 0.0031 0.0305
Echinococcus multilocularis protein patched 0.0042 0.0149 0.0227
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.0176 0.0707 0.0696
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0048 0.0173 0.2301
Loa Loa (eye worm) matrix metalloproteinase 0.0125 0.0493 0.0481
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0141 0.0563 0.0912
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0015 0.0003
Schistosoma mansoni DNA polymerase eta 0.0015 0.0037 0.0024
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0048 0.0173 0.2687
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.001 0.0015 0.0002
Plasmodium falciparum glutathione reductase 0.0037 0.0125 0.193
Brugia malayi Trypsin family protein 0.0176 0.0707 0.0696
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.001 0.0013 0.0067
Echinococcus multilocularis tar DNA binding protein 0.0065 0.0243 0.0382
Mycobacterium ulcerans acyl-CoA synthetase 0.0048 0.0173 0.2301
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0062 0.0233 0.0221
Mycobacterium ulcerans DNA polymerase IV 0.0044 0.0155 0.2038
Entamoeba histolytica hypothetical protein 0.0036 0.0123 0.2949
Echinococcus multilocularis thioredoxin glutathione reductase 0.0037 0.0127 0.019
Onchocerca volvulus 0.001 0.0015 0.0001
Treponema pallidum NADH oxidase 0.0013 0.0025 1
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0015 0.0037 0.0023
Loa Loa (eye worm) hypothetical protein 0.0032 0.0105 0.0091
Trichomonas vaginalis mercuric reductase, putative 0.0013 0.0025 0.0125
Echinococcus multilocularis inositol monophosphatase 1 0.0038 0.013 0.0195
Onchocerca volvulus 0.0148 0.0592 0.0579
Plasmodium vivax glutathione reductase, putative 0.0037 0.0125 0.193
Echinococcus granulosus neuropeptide receptor A26 0.0955 0.3968 0.6553
Brugia malayi steroid hormone receptor 0.001 0.0015 0.0003
Trypanosoma brucei DNA polymerase eta, putative 0.0015 0.0037 0.0677
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0014 0.0031 0.0489
Trichomonas vaginalis replication factor C large subunit, putative 0.001 0.0013 0.0067
Mycobacterium ulcerans acyl-CoA synthetase 0.0048 0.0173 0.2301
Brugia malayi Matrixin family protein 0.0125 0.0493 0.0483
Echinococcus granulosus ecdysone induced protein 78C 0.001 0.0015 0.0004
Loa Loa (eye worm) hypothetical protein 0.001 0.0015 0.0001
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0243 0.0231
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0155 0.062 0.0608
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0015 0.0003
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0013 0.0025 0.0169
Loa Loa (eye worm) hypothetical protein 0.001 0.0015 0.0001
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0141 0.0563 0.0551
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0243 0.0231
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.0031 0.0489
Brugia malayi Latrophilin receptor protein 2 0.0049 0.0177 0.0166
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0015 0.0003
Echinococcus multilocularis matrix metallopeptidase 7 (M10 family) 0.0453 0.1867 0.3074
Echinococcus granulosus survival motor neuron protein 1 0.0237 0.0964 0.1577
Brugia malayi glutathione reductase 0.0037 0.0125 0.0114
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0044 0.0158 0.0782
Trypanosoma brucei unspecified product 0.0011 0.0017 0.0091
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.001 0.0015 0.0001
Trichomonas vaginalis inositol monophosphatase, putative 0.0038 0.013 0.0644
Loa Loa (eye worm) hypothetical protein 0.0048 0.0173 0.016
Trichomonas vaginalis CAMK family protein kinase 0.0091 0.0354 0.1752
Brugia malayi Matrixin family protein 0.0125 0.0493 0.0483
Trypanosoma brucei DNA polymerase kappa, putative 0.0044 0.0155 0.4149
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.0114 0.1858
Brugia malayi hypothetical protein 0.001 0.0013 0.0002
Trypanosoma brucei polo-like protein kinase 0.0091 0.0354 1
Trichomonas vaginalis CAMK family protein kinase 0.0091 0.0354 0.1752
Loa Loa (eye worm) inositol-1 0.0038 0.013 0.0117
Schistosoma mansoni chromosome transmission fidelity factor 0.001 0.0013 0.0001
Mycobacterium ulcerans hydrolase 0.0152 0.0607 0.8563
Mycobacterium ulcerans hypothetical protein 0.0048 0.0173 0.2301
Schistosoma mansoni hypothetical protein 0.0032 0.0105 0.0093
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0015 0.0004
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.013 0.3425
Brugia malayi Nuclear hormone receptor family member nhr-1 0.001 0.0015 0.0003
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0022 0.0066 0.1063
Trichomonas vaginalis glucosylceramidase, putative 0.0259 0.1055 0.5225
Loa Loa (eye worm) hypothetical protein 0.0106 0.0415 0.0402
Brugia malayi latrophilin 2 splice variant baaae 0.0106 0.0415 0.0405
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0014 0.0031 0.0255
Echinococcus multilocularis dna polymerase kappa 0.0044 0.0155 0.0236
Onchocerca volvulus Protein ultraspiracle homolog 0.001 0.0015 0.0001
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.0015 0.0002
Brugia malayi RNA binding protein 0.0065 0.0243 0.0232
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0066 0.1539
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0038 0.013 0.0644
Schistosoma mansoni hypothetical protein 0.0049 0.0177 0.0165
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0013 0.0067
Giardia lamblia DINP protein human, muc B family 0.0022 0.0066 0.1539
Trichomonas vaginalis glucosylceramidase, putative 0.017 0.0683 0.3381
Brugia malayi hypothetical protein 0.001 0.0013 0.0002
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0032 0.0105 0.0154
Echinococcus granulosus thioredoxin glutathione reductase 0.0037 0.0127 0.019
Schistosoma mansoni coup transcription factor 0.001 0.0015 0.0002
Loa Loa (eye worm) hypothetical protein 0.0033 0.011 0.0097
Trypanosoma brucei DNA polymerase kappa, putative 0.0033 0.011 0.2846
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0042 0.0149 0.0136
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.001 0.0013 0.0000031374
Loa Loa (eye worm) hypothetical protein 0.0099 0.0385 0.0372
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0011 0.002 0.0012
Entamoeba histolytica deoxycytidyl transferase, putative 0.0015 0.0037 0.062
Loa Loa (eye worm) hypothetical protein 0.0125 0.0493 0.0481
Trypanosoma brucei DNA polymerase IV, putative 0.0044 0.0155 0.4149
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.001 0.0015 0.0001
Onchocerca volvulus Matrix metalloproteinase homolog 0.0276 0.1128 0.1116
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0083 0.0321 0.5275
Trichomonas vaginalis glucosylceramidase, putative 0.017 0.0683 0.3381
Trypanosoma brucei DNA polymerase kappa, putative 0.0018 0.0046 0.0952
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0038 0.013 0.0446
Echinococcus multilocularis cpg binding protein 0.0031 0.0102 0.0149
Toxoplasma gondii kringle domain-containing protein 0.0148 0.0592 1
Echinococcus granulosus tissue type plasminogen activator 0.0148 0.0592 0.096
Mycobacterium tuberculosis Probable peptidoglycan hydrolase 0.0152 0.0607 1
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0062 0.0233 0.0221
Trichomonas vaginalis glucosylceramidase, putative 0.017 0.0683 0.3381
Trichomonas vaginalis glucosylceramidase, putative 0.0259 0.1055 0.5225
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0015 0.0004
Brugia malayi Trypsin family protein 0.0176 0.0707 0.0696
Schistosoma mansoni hypothetical protein 0.0148 0.0592 0.058
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0032 0.0105 0.0091
Schistosoma mansoni cercarial elastase (S01 family) 0.0176 0.0707 0.0695
Trichomonas vaginalis glucosylceramidase, putative 0.0259 0.1055 0.5225
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0014 0.0031 0.0489
Loa Loa (eye worm) hypothetical protein 0.0048 0.0173 0.016
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0013 0.0067
Echinococcus multilocularis thyroid hormone receptor alpha 0.001 0.0015 0.0004
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0049 0.0177 0.0273
Schistosoma mansoni cercarial elastase (S01 family) 0.0176 0.0707 0.0695
Schistosoma mansoni hypothetical protein 0.0041 0.0143 0.0131
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0014 0.0031 0.0305
Brugia malayi polk-prov protein 0.0033 0.011 0.0099
Schistosoma mansoni ankyrin 23/unc44 0.0032 0.0105 0.0093
Loa Loa (eye worm) hypothetical protein 0.0051 0.0184 0.017
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0044 0.0158 0.2499
Trypanosoma brucei DNA polymerase kappa, putative 0.0044 0.0155 0.4149
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0014 0.0031 0.0255
Mycobacterium ulcerans DNA polymerase IV 0.0044 0.0155 0.2038
Echinococcus multilocularis Mastin 0.0176 0.0707 0.1151
Brugia malayi Nuclear hormone receptor family member nhr-31 0.001 0.0015 0.0003
Loa Loa (eye worm) hypothetical protein 0.0036 0.0122 0.0109
Trypanosoma brucei DNA polymerase kappa, putative 0.0044 0.0155 0.4149
Brugia malayi AMP-binding enzyme family protein 0.0014 0.0031 0.002
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0014 0.0031 0.0305
Trichomonas vaginalis CAMK family protein kinase 0.0091 0.0354 0.1752
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0083 0.0321 0.518
Entamoeba histolytica acetyltransferase, GNAT family 0.0041 0.0142 0.3471
Leishmania major DNA polymerase eta, putative 0.0015 0.0037 0.0201
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0049 0.0177 0.0166
Schistosoma mansoni hypothetical protein 0.0106 0.0415 0.0403
Mycobacterium ulcerans acyl-CoA synthetase 0.0014 0.0031 0.0255
Echinococcus granulosus Ankyrin 0.0032 0.0105 0.0154
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.001 0.0015 0.0004
Echinococcus granulosus dna polymerase eta 0.0015 0.0037 0.004
Schistosoma mansoni terminal deoxycytidyl transferase 0.0015 0.0037 0.0024
Loa Loa (eye worm) glutathione reductase 0.0037 0.0125 0.0112
Echinococcus multilocularis GPCR, family 2 0.0049 0.0177 0.0273
Brugia malayi CXXC zinc finger family protein 0.0029 0.0095 0.0084
Leishmania major 4-coumarate:coa ligase-like protein 0.0048 0.0173 0.2609
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.0031 0.0489
Onchocerca volvulus 0.0014 0.0031 0.0018
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.0031 0.0489
Schistosoma mansoni cellular tumor antigen P53 0.0051 0.0184 0.0172
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.001 0.0015 0.0002
Echinococcus granulosus netrin receptor unc 5 0.0032 0.0105 0.0154
Trypanosoma cruzi trypanothione reductase, putative 0.0013 0.0025 0.0202
Mycobacterium tuberculosis Probable oxidoreductase 0.0093 0.036 0.5918
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.0025 0.0202
Echinococcus multilocularis glycoprotein Antigen 5 0.0176 0.0707 0.1151
Schistosoma mansoni hypothetical protein 0.0049 0.0177 0.0165
Loa Loa (eye worm) steroid hormone receptor 0.001 0.0015 0.0001
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0049 0.0177 0.0273
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0065 0.0243 0.023
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0038 0.013 0.0644
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0015 0.0037 0.004
Entamoeba histolytica serine/threonine protein kinase, putative 0.0091 0.0354 0.9162
Mycobacterium ulcerans acyl-CoA synthetase 0.0014 0.0031 0.0255
Plasmodium vivax acyl-CoA synthetase, putative 0.0036 0.0122 0.188
Echinococcus granulosus expressed conserved protein 0.0093 0.036 0.0576
Brugia malayi Pre-SET motif family protein 0.043 0.1772 0.1763
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0176 0.0707 0.0695
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0141 0.0563 0.0551
Mycobacterium ulcerans acyl-CoA synthetase 0.0014 0.0031 0.0255
Echinococcus granulosus GPCR family 2 0.0049 0.0177 0.0273
Trypanosoma brucei DNA polymerase kappa, putative 0.0033 0.011 0.2846
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.001 0.0013 0.0067
Echinococcus granulosus death domain containing protein 0.0032 0.0105 0.0154
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0013 0.0025 0.0202
Trichomonas vaginalis CAMK family protein kinase 0.0091 0.0354 0.1752
Trichomonas vaginalis glucosylceramidase, putative 0.017 0.0683 0.3381
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0083 0.0321 0.5275
Loa Loa (eye worm) hypothetical protein 0.0015 0.0037 0.0023
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0014 0.0031 0.002
Schistosoma mansoni topbp1 0.001 0.0013 0.0001
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0036 0.0122 1
Brugia malayi hypothetical protein 0.0036 0.0123 0.0112
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0014 0.0031 0.0519
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.043 0.1772 0.1761
Trichomonas vaginalis antibiotic synthetase, putative 0.0014 0.0031 0.0154
Schistosoma mansoni cpg binding protein 0.0031 0.0102 0.009
Schistosoma mansoni serine/threonine protein kinase 0.0091 0.0354 0.0342
Trichomonas vaginalis CAMK family protein kinase 0.0091 0.0354 0.1752
Schistosoma mansoni hypothetical protein 0.0041 0.0143 0.0131
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0015 0.0003
Loa Loa (eye worm) hypothetical protein 0.0032 0.0105 0.0092
Schistosoma mansoni retinoic acid receptor RXR 0.001 0.0015 0.0002
Brugia malayi nuclear hormone receptor 0.001 0.0015 0.0003
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0015 0.0003
Echinococcus granulosus tar DNA binding protein 0.0065 0.0243 0.0382
Brugia malayi photoreceptor-specific nuclear receptor 0.001 0.0015 0.0003
Loa Loa (eye worm) hypothetical protein 0.0125 0.0493 0.0481
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0062 0.0233 0.0221
Brugia malayi Trypsin family protein 0.0176 0.0707 0.0696
Brugia malayi Kringle domain containing protein 0.0148 0.0592 0.0581
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0013 0.0025 0.0169
Brugia malayi Immunoglobulin I-set domain containing protein 0.0032 0.0105 0.0094
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0151 0.0604 0.0593
Trypanosoma cruzi polo-like protein kinase, putative 0.0091 0.0354 0.5888
Schistosoma mansoni survival motor neuron protein 0.0048 0.0174 0.0163
Echinococcus granulosus histone acetyltransferase KAT2B 0.0147 0.0586 0.0951
Mycobacterium ulcerans acyl-CoA synthetase 0.0014 0.0031 0.0255
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.001 0.0015 0.0004
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0049 0.0177 0.0273
Mycobacterium tuberculosis Probable dehydrogenase 0.0083 0.0321 0.5275
Schistosoma mansoni DNA ligase IV 0.001 0.0013 0.0001
Loa Loa (eye worm) TK/ROR protein kinase 0.0148 0.0592 0.0579
Entamoeba histolytica acyl-CoA synthetase, putative 0.0048 0.0173 0.4292
Brugia malayi AMP-binding enzyme family protein 0.0014 0.0031 0.002
Trichomonas vaginalis glucosylceramidase, putative 0.017 0.0683 0.3381
Brugia malayi CHE-14 protein 0.0042 0.0149 0.0138
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0015 0.0004
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0091 0.0354 0.5803
Brugia malayi Nuclear hormone receptor family member nhr-41 0.001 0.0015 0.0003
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0155 0.062 0.061
Echinococcus granulosus histone acetyltransferase KAT2B 0.0044 0.0158 0.0242
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.0025 0.0202
Loa Loa (eye worm) hypothetical protein 0.001 0.0015 0.0001
Brugia malayi Thioredoxin reductase 0.0037 0.0125 0.0114
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0014 0.0031 0.0255
Trypanosoma brucei DNA polymerase kappa, putative 0.0044 0.0155 0.4149
Echinococcus multilocularis tissue type plasminogen activator 0.0148 0.0592 0.096
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0014 0.0031 0.0305
Echinococcus multilocularis replication factor c subunit 1 0.001 0.0013 0.0002
Onchocerca volvulus 0.0176 0.0707 0.0694
Toxoplasma gondii NADPH-glutathione reductase 0.0013 0.0025 0.0202
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.013 0.2016
Echinococcus multilocularis survival motor neuron protein 1 0.0237 0.0964 0.1577
Brugia malayi AMP-binding enzyme family protein 0.0048 0.0173 0.0162
Loa Loa (eye worm) hypothetical protein 0.0014 0.0031 0.0018
Loa Loa (eye worm) hypothetical protein 0.0176 0.0707 0.0694
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.001 0.0015 0.0001
Echinococcus multilocularis Ankyrin 0.0032 0.0105 0.0154
Echinococcus granulosus sterol regulatory element binding protein 0.0042 0.0149 0.0227
Plasmodium vivax SET domain protein, putative 0.0062 0.0233 0.3789
Plasmodium falciparum thioredoxin reductase 0.0037 0.0125 0.193
Onchocerca volvulus Bile acid receptor homolog 0.001 0.0015 0.0001
Mycobacterium ulcerans acyl-CoA synthetase 0.0014 0.0031 0.0255
Loa Loa (eye worm) histone methyltransferase 0.0011 0.002 0.0006
Trichomonas vaginalis antibiotic synthetase, putative 0.0014 0.0031 0.0154
Brugia malayi AMP-binding enzyme family protein 0.0014 0.0031 0.002
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.0025 0.0202
Onchocerca volvulus 0.0018 0.0048 0.0034
Mycobacterium ulcerans hypothetical protein 0.0176 0.0707 1
Schistosoma mansoni cercarial elastase (S01 family) 0.0176 0.0707 0.0695
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.2397 1 1
Loa Loa (eye worm) RNA binding protein 0.0065 0.0243 0.023
Trichomonas vaginalis glucosylceramidase, putative 0.0259 0.1055 0.5225
Schistosoma mansoni topbp1 0.001 0.0013 0.0001
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0048 0.0173 0.2301
Trypanosoma brucei DNA polymerase kappa, putative 0.0044 0.0155 0.4149
Brugia malayi Pre-SET motif family protein 0.0062 0.0233 0.0222
Schistosoma mansoni hypothetical protein 0.0048 0.0174 0.0163
Trichomonas vaginalis glucosylceramidase, putative 0.0259 0.1055 0.5225
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0176 0.0707 0.0695
Echinococcus multilocularis protein dispatched 1 0.0048 0.0174 0.0269
Trypanosoma brucei DNA polymerase kappa, putative 0.0018 0.0046 0.0952
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0038 0.013 0.3137
Echinococcus multilocularis neuropeptide receptor A26 0.0955 0.3968 0.6553
Echinococcus granulosus transmembrane protease serine 3 0.0176 0.0707 0.1151
Leishmania major acetyl-CoA synthetase, putative 0.0014 0.0031 0.0105
Loa Loa (eye worm) hypothetical protein 0.001 0.0015 0.0001
Brugia malayi Matrixin family protein 0.0125 0.0493 0.0483
Brugia malayi AMP-binding enzyme family protein 0.0014 0.0031 0.002
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0014 0.0031 0.0489
Brugia malayi Death domain containing protein 0.0032 0.0105 0.0094
Onchocerca volvulus 0.0014 0.0031 0.0018
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.013 0.2016
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0014 0.0031 0.0018
Loa Loa (eye worm) hypothetical protein 0.0176 0.0707 0.0694
Brugia malayi TAR-binding protein 0.0065 0.0243 0.0232
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.0114 0.1858
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0014 0.0031 0.0489
Brugia malayi Nuclear hormone receptor family member nhr-40 0.001 0.0015 0.0003
Trichomonas vaginalis CAMK family protein kinase 0.0091 0.0354 0.1752
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0083 0.0321 0.5275
Echinococcus granulosus enteropeptidase 0.0176 0.0707 0.1151
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0044 0.0158 0.2499
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0014 0.0031 0.0305
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0015 0.0003
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.001 0.0015 0.0001
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0093 0.036 0.5918
Trypanosoma brucei DNA polymerase IV, putative 0.0044 0.0155 0.4149
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.0025 0.0202
Echinococcus granulosus cpg binding protein 0.0031 0.0102 0.0149
Toxoplasma gondii histone lysine methyltransferase SET1 0.0062 0.023 0.374
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0012 0.0021 0.0139
Loa Loa (eye worm) hypothetical protein 0.0176 0.0707 0.0694
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0013 0.0025 0.0014
Giardia lamblia Histone acetyltransferase GCN5 0.0041 0.0142 0.3789
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0013 0.0025 0.0343
Echinococcus multilocularis microtubule associated protein 2 0.1452 0.6048 1
Trypanosoma brucei trypanothione reductase 0.0037 0.0125 0.3278
Trichomonas vaginalis glucosylceramidase, putative 0.017 0.0683 0.3381
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0141 0.0563 0.0912
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.001 0.0015 0.0001
Trypanosoma cruzi DNA polymerase kappa, putative 0.0044 0.0155 0.2443
Mycobacterium ulcerans acetyl-CoA synthetase 0.0014 0.0031 0.0255
Schistosoma mansoni cercarial elastase (S01 family) 0.0176 0.0707 0.0695
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0176 0.0707 0.0695
Trypanosoma cruzi polo-like protein kinase, putative 0.0091 0.0354 0.5888
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0123 0.0111
Loa Loa (eye worm) hypothetical protein 0.001 0.0015 0.0001
Mycobacterium leprae PROBABLE HYDROLASE 0.0152 0.0607 1
Echinococcus granulosus nibrin 0.001 0.0013 0.0002
Loa Loa (eye worm) hypothetical protein 0.0014 0.0031 0.0018
Schistosoma mansoni cercarial elastase (S01 family) 0.0176 0.0707 0.0695
Schistosoma mansoni niemann-pick C1 (NPC1) 0.01 0.0392 0.038
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0013 0.0025 0.0343
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0015 0.0037 0.004
Brugia malayi Protein kinase domain containing protein 0.0148 0.0592 0.0581
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.0025 0.0202
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0243 0.0231
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0013 0.0025 0.0202
Loa Loa (eye worm) oxidoreductase 0.0014 0.0031 0.0018
Onchocerca volvulus 0.049 0.202 0.201
Echinococcus multilocularis netrin receptor unc 5 0.0032 0.0105 0.0154
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0014 0.0031 0.0255
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0013 0.0025 0.0343
Brugia malayi Matrixin family protein 0.0125 0.0493 0.0483
Brugia malayi Nuclear hormone receptor family member nhr-49 0.001 0.0015 0.0003
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.001 0.0015 0.0004
Brugia malayi Matrixin family protein 0.0301 0.1233 0.1223
Schistosoma mansoni cercarial elastase (S01 family) 0.0176 0.0707 0.0695
Trichomonas vaginalis CAMK family protein kinase 0.0045 0.0161 0.0798
Trypanosoma brucei DNA polymerase kappa, putative 0.0044 0.0155 0.4149
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.001 0.0015 0.0002
Brugia malayi ecdysteroid receptor 0.001 0.0015 0.0003
Brugia malayi ImpB/MucB/SamB family protein 0.0015 0.0037 0.0025
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.001 0.0015 0.0004
Mycobacterium ulcerans acyl-CoA synthetase 0.0014 0.0031 0.0255
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0015 0.0003
Loa Loa (eye worm) matrixin family protein 0.0276 0.1128 0.1116
Leishmania major 4-coumarate:coa ligase-like protein 0.0048 0.0173 0.2609
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0036 0.0122 0.1569
Schistosoma mansoni cercarial elastase (S01 family) 0.0176 0.0707 0.0695
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.0176 0.0707 0.1151
Onchocerca volvulus 0.0029 0.0095 0.0082
Leishmania major acetyl-CoA synthetase, putative 0.0014 0.0031 0.0105
Schistosoma mansoni matrix metallopeptidase-9 (M10 family) 0.0114 0.0448 0.0436
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0123 0.0184
Loa Loa (eye worm) TAR-binding protein 0.0065 0.0243 0.023
Schistosoma mansoni inositol monophosphatase 0.0038 0.013 0.0118
Mycobacterium ulcerans acyl-CoA synthetase 0.0014 0.0031 0.0255
Mycobacterium tuberculosis Probable reductase 0.0083 0.0321 0.5275
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0062 0.0233 0.0365
Schistosoma mansoni Tr4/Tr2 (homologue) 0.001 0.0015 0.0002
Echinococcus granulosus Niemann Pick C1 protein 0.0141 0.0562 0.0911
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.001 0.0015 0.0004
Onchocerca volvulus 0.2221 0.9266 0.9265
Onchocerca volvulus 0.0014 0.0031 0.0018
Toxoplasma gondii propionate-CoA ligase 0.0014 0.0031 0.0305
Onchocerca volvulus 0.0062 0.0233 0.0219
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.2397 1 1
Trypanosoma cruzi hypothetical protein, conserved 0.0148 0.0592 1
Loa Loa (eye worm) thioredoxin reductase 0.0037 0.0125 0.0112
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0038 0.013 0.2016
Loa Loa (eye worm) hypothetical protein 0.0152 0.0607 0.0594
Schistosoma mansoni cercarial elastase (S01 family) 0.0176 0.0707 0.0695
Echinococcus multilocularis ecdysone induced protein 78C 0.001 0.0015 0.0004
Trypanosoma brucei DNA polymerase kappa, putative 0.0018 0.0046 0.0952
Schistosoma mansoni RAR-like nuclear receptor 0.001 0.0015 0.0002
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0014 0.0031 0.002
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0259 0.1055 0.1043
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0015 0.0037 0.0024
Schistosoma mansoni cpg binding protein 0.0029 0.0095 0.0083
Trichomonas vaginalis CAMK family protein kinase 0.0045 0.0161 0.0798
Echinococcus multilocularis muscleblind protein 0.0153 0.0611 0.0992
Echinococcus granulosus tumor protein p63 0.0345 0.1417 0.2327
Echinococcus granulosus glycoprotein Antigen 5 0.0176 0.0707 0.1151
Plasmodium vivax acetyl-CoA synthetase, putative 0.0014 0.0031 0.0305
Echinococcus multilocularis nuclear factor of activated T cells 5 0.031 0.1269 0.2083
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0093 0.036 0.5918
Brugia malayi nuclear receptor NHR-88 0.001 0.0015 0.0003
Schistosoma mansoni hypothetical protein 0.0176 0.0707 0.0695
Plasmodium vivax thioredoxin reductase, putative 0.0037 0.0125 0.193
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0014 0.0031 0.0305
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0036 0.0122 0.1993
Onchocerca volvulus Glucosylceramidase homolog 0.017 0.0683 0.067
Trypanosoma cruzi DNA polymerase kappa, putative 0.0044 0.0155 0.2443
Trichomonas vaginalis DNA polymerase eta, putative 0.0044 0.0155 0.0766
Mycobacterium tuberculosis Conserved hypothetical protein 0.0015 0.0037 0.0578
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0013 0.0025 0.0391
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.001 0.0015 0.0004
Schistosoma mansoni thyroid hormone receptor 0.001 0.0015 0.0002
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0037 0.0125 0.2041
Schistosoma mansoni inositol monophosphatase 0.0038 0.013 0.0118
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0013 0.0025 0.0169
Mycobacterium ulcerans acyl-CoA synthetase 0.0014 0.0031 0.0255
Brugia malayi AMP-binding enzyme family protein 0.0048 0.0173 0.0162
Onchocerca volvulus 0.2397 1 1
Brugia malayi ImpB/MucB/SamB family protein 0.0015 0.0037 0.0025
Onchocerca volvulus 0.0176 0.0707 0.0694
Echinococcus multilocularis dna polymerase eta 0.0015 0.0037 0.004
Brugia malayi Nuclear hormone receptor family member nhr-3 0.001 0.0015 0.0003
Entamoeba histolytica hypothetical protein 0.0036 0.0123 0.2949
Schistosoma mansoni netrin receptor unc5 0.0032 0.0105 0.0093
Schistosoma mansoni polycystin 1-related 0.0056 0.0205 0.0194
Schistosoma mansoni steroid hormone receptor ad4bp 0.001 0.0015 0.0002
Echinococcus granulosus neuropeptide s receptor 0.0955 0.3968 0.6553
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0141 0.0563 0.0912
Echinococcus multilocularis nibrin 0.001 0.0013 0.0002
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0014 0.0031 0.0018
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0013 0.0025 0.0202
Plasmodium falciparum glutathione reductase 0.0013 0.0025 0.0202
Loa Loa (eye worm) hypothetical protein 0.0176 0.0707 0.0694
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0141 0.0563 0.0912
Echinococcus granulosus Mastin 0.0176 0.0707 0.1151
Echinococcus granulosus replication factor c subunit 1 0.001 0.0013 0.0002
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0013 0.0025 0.0045
Echinococcus multilocularis Niemann Pick C1 protein 0.0099 0.0385 0.0618
Mycobacterium leprae POSSIBLE FATTY-ACID-CoA LIGASE FADD10 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0014 0.0031 0.0298
Echinococcus granulosus Niemann Pick C1 protein 0.0099 0.0385 0.0618
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0034 0.0114 0.185
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0013 0.0025 0.0022
Giardia lamblia NADH oxidase lateral transfer candidate 0.0013 0.0025 0.0343
Brugia malayi Uncoordinated protein 44 0.0032 0.0105 0.0094
Loa Loa (eye worm) hypothetical protein 0.0036 0.0122 0.0109
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0013 0.0025 0.0202
Loa Loa (eye worm) hypothetical protein 0.0042 0.0149 0.0136
Onchocerca volvulus Matrilysin homolog 0.0125 0.0493 0.0481
Echinococcus multilocularis tumor protein p63 0.0345 0.1417 0.2327
Echinococcus multilocularis enteropeptidase 0.0176 0.0707 0.1151
Trypanosoma cruzi DNA polymerase kappa, putative 0.0044 0.0155 0.2443
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0176 0.0707 0.0695
Schistosoma mansoni cercarial elastase (S01 family) 0.0176 0.0707 0.0695
Toxoplasma gondii thioredoxin reductase 0.0037 0.0125 0.193
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0048 0.0173 0.2687
Echinococcus multilocularis neuropeptide s receptor 0.0955 0.3968 0.6553
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.013 0.1852
Trypanosoma cruzi DNA polymerase eta, putative 0.0015 0.0037 0.0399
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0093 0.036 0.5836
Onchocerca volvulus 0.0176 0.0707 0.0694
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0141 0.0563 0.055
Trypanosoma brucei DNA polymerase kappa, putative 0.0044 0.0155 0.4149
Entamoeba histolytica acyl-coA synthetase, putative 0.0048 0.0173 0.4292
Brugia malayi Matrix metalloprotease, N-terminal domain containing protein 0.0152 0.0607 0.0597
Schistosoma mansoni hypothetical protein 0.0041 0.0143 0.0131
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0083 0.0321 0.5275
Loa Loa (eye worm) hypothetical protein 0.0036 0.0122 0.0109
Brugia malayi acetyltransferase, GNAT family protein 0.0151 0.0604 0.0594
Onchocerca volvulus 0.0176 0.0707 0.0694
Trichomonas vaginalis glucosylceramidase, putative 0.0179 0.0721 0.357
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.001 0.0013 0.0002
Loa Loa (eye worm) hypothetical protein 0.0052 0.0189 0.0176
Onchocerca volvulus 0.0051 0.0184 0.017
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0091 0.0354 0.0341
Trypanosoma brucei DNA polymerase kappa, putative 0.0044 0.0155 0.4149
Schistosoma mansoni matrix metallopeptidase-7 (M10 family) 0.0125 0.0493 0.0482
Giardia lamblia Kinase, PLK 0.0091 0.0354 1
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0011 0.002 0.0012
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0048 0.0173 0.2832
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0013 0.0067
Loa Loa (eye worm) hypothetical protein 0.0155 0.062 0.0608
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.001 0.0015 0.0001
Loa Loa (eye worm) hypothetical protein 0.0176 0.0707 0.0694
Echinococcus multilocularis expressed conserved protein 0.0093 0.036 0.0576
Echinococcus granulosus Protein patched homolog 1 0.0042 0.0149 0.0227
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0015 0.0004
Leishmania major hypothetical protein, conserved 0.0148 0.0592 1
Loa Loa (eye worm) hypothetical protein 0.0153 0.0611 0.0598
Schistosoma mansoni patched 1 0.0042 0.0149 0.0137
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0013 0.0025 0.0013
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0091 0.0354 0.0566
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0013 0.0025 0.0202
Echinococcus granulosus muscleblind protein 0.0153 0.0611 0.0992
Loa Loa (eye worm) hypothetical protein 0.0049 0.0177 0.0164
Brugia malayi Niemann-Pick C1 protein precursor 0.0099 0.0385 0.0374
Mycobacterium leprae POSSIBLE O-SUCCINYLBENZOIC ACID--CoA LIGASE MENE (OSB-CoA SYNTHETASE) (O-SUCCINYLBENZOATE-CoA SYNTHASE) 0.0014 0.0031 0.0298
Leishmania major trypanothione reductase 0.0037 0.0125 0.1763
Onchocerca volvulus 0.0125 0.0493 0.0481
Trypanosoma brucei DNA polymerase kappa, putative 0.0044 0.0155 0.4149
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0243 0.0231
Schistosoma mansoni hypothetical protein 0.0049 0.0177 0.0165
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.0176 0.0707 0.1151
Brugia malayi hypothetical protein 0.0237 0.0964 0.0954
Brugia malayi hypothetical protein 0.0176 0.0707 0.0696
Brugia malayi topoisomerase 0.001 0.0013 0.0002
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0176 0.0707 0.0695
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0099 0.0385 1
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0014 0.0031 0.0489
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.0176 0.0707 0.1151
Echinococcus granulosus microtubule associated protein 2 0.1452 0.6048 1
Trichomonas vaginalis set domain proteins, putative 0.0489 0.202 1
Brugia malayi Steroid receptor seven-up type 2 0.001 0.0015 0.0003
Onchocerca volvulus 0.0176 0.0707 0.0694
Entamoeba histolytica hypothetical protein 0.0036 0.0123 0.2949
Plasmodium falciparum cysteine repeat modular protein 1 0.0148 0.0592 1
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0259 0.1055 0.1045
Brugia malayi Calcitonin receptor-like protein seb-1 0.0155 0.062 0.061
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0038 0.013 0.1682
Echinococcus granulosus FTZ F1 alpha 0.001 0.0015 0.0004
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0151 0.0604 0.098
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0014 0.0031 0.0475
Trypanosoma cruzi DNA polymerase kappa, putative 0.0044 0.0155 0.2443
Trichomonas vaginalis CAMK family protein kinase 0.0091 0.0354 0.1752
Loa Loa (eye worm) hypothetical protein 0.0237 0.0964 0.0952
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0243 0.0231
Echinococcus granulosus dna polymerase kappa 0.0044 0.0155 0.0236
Schistosoma mansoni hypothetical protein 0.0049 0.0177 0.0165
Schistosoma mansoni hypothetical protein 0.0177 0.0711 0.07
Trypanosoma brucei unspecified product 0.0037 0.0125 0.3288
Brugia malayi DKFZp564C0469 protein 0.001 0.0013 0.0002
Trypanosoma brucei unspecified product 0.0011 0.0017 0.0091
Loa Loa (eye worm) hypothetical protein 0.2397 1 1
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.001 0.0013 0.0067
Onchocerca volvulus Netrin receptor homolog 0.0032 0.0105 0.0091
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0032 0.0105 0.0154
Onchocerca volvulus Serine\/threonine kinase homolog 0.0091 0.0354 0.0341
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0014 0.0031 0.0255
Schistosoma mansoni cercarial elastase (S01 family) 0.0176 0.0707 0.0695
Loa Loa (eye worm) hypothetical protein 0.0062 0.0233 0.0219
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0123 0.0184
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0141 0.0563 0.0551
Entamoeba histolytica hypothetical protein 0.0036 0.0123 0.2949
Echinococcus multilocularis sterol regulatory element binding protein 0.0042 0.0149 0.0227
Loa Loa (eye worm) hypothetical protein 0.0048 0.0173 0.016
Onchocerca volvulus 0.0048 0.0173 0.016
Brugia malayi Muscleblind-like protein 0.0153 0.0611 0.06
Echinococcus granulosus nuclear factor of activated T cells 5 0.031 0.1269 0.2083
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0014 0.0031 0.0255
Brugia malayi Nuclear hormone receptor family member nhr-14 0.001 0.0015 0.0003
Loa Loa (eye worm) latrophilin receptor protein 2 0.0049 0.0177 0.0164
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0048 0.0173 0.2301
Brugia malayi serine/threonine-protein kinase plk-2 0.0091 0.0354 0.0343
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0014 0.0031 0.0031
Loa Loa (eye worm) hypothetical protein 0.0148 0.0592 0.0579
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0014 0.0031 0.0305
Brugia malayi RNA recognition motif domain containing protein 0.0065 0.0243 0.0232
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0013 0.0067
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0149 0.074
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.001 0.0013 0.0067
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.001 0.0015 0.0002
Onchocerca volvulus Matrilysin homolog 0.0276 0.1128 0.1116
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0014 0.0031 0.0105
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0062 0.0233 0.0221
Schistosoma mansoni microtubule-associated protein tau 0.1452 0.6048 0.6043
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0013 0.0025 0.1075
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0048 0.0173 0.2832
Trichomonas vaginalis bromodomain-containing protein, putative 0.0044 0.0158 0.0782
Plasmodium falciparum thioredoxin reductase 0.0013 0.0025 0.0202
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0013 0.0025 0.0022
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0062 0.0233 0.0365
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.001 0.0015 0.0004
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0065 0.0242 0.023
Mycobacterium tuberculosis PROBABLE FATTY-ACID-CoA LIGASE FADD18 (FRAGMENT) (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0012 0.0023 0.0354
Brugia malayi F/Y-rich N-terminus family protein 0.0011 0.0019 0.0008
Trichomonas vaginalis glutathione reductase, putative 0.0013 0.0025 0.0125
Echinococcus multilocularis FTZ F1 alpha 0.001 0.0015 0.0004
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0013 0.0025 0.0202
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.0114 0.1858
Mycobacterium ulcerans acyl-CoA synthetase 0.0048 0.0173 0.2301
Schistosoma mansoni kinase 0.0046 0.0166 0.0154
Echinococcus granulosus inositol monophosphatase 1 0.0038 0.013 0.0195
Trypanosoma cruzi trypanothione reductase, putative 0.0037 0.0125 0.193
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0034 0.0114 0.1686
Echinococcus granulosus retinoic acid receptor rxr beta a 0.001 0.0015 0.0004
Plasmodium falciparum acyl-CoA synthetase 0.0036 0.0122 0.188
Trichomonas vaginalis glucosylceramidase, putative 0.0179 0.0721 0.357
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.001 0.0015 0.0004
Plasmodium falciparum histone acetyltransferase GCN5 0.0041 0.0142 0.2231
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0022 0.0066 0.0718
Trichomonas vaginalis glucosylceramidase, putative 0.0259 0.1055 0.5225
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0014 0.0031 0.0255
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0014 0.0031 0.0255
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0062 0.0233 0.3789
Loa Loa (eye worm) hypothetical protein 0.001 0.0015 0.0001
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0148 0.0592 1
Loa Loa (eye worm) hypothetical protein 0.0153 0.0611 0.0598
Echinococcus multilocularis transmembrane protease serine 3 0.0176 0.0707 0.1151
Loa Loa (eye worm) trypsin family protein 0.0176 0.0707 0.0694
Brugia malayi Protein kinase domain containing protein 0.0032 0.0106 0.0095
Brugia malayi Trypsin-like protease protein 5 0.0176 0.0707 0.0696
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.0025 0.0202
Loa Loa (eye worm) hypothetical protein 0.001 0.0015 0.0001
Loa Loa (eye worm) hypothetical protein 0.001 0.0015 0.0001
Schistosoma mansoni hypothetical protein 0.0036 0.0123 0.0111
Schistosoma mansoni nuclear hormone receptor 0.001 0.0015 0.0002
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.0114 0.1858
Loa Loa (eye worm) hypothetical protein 0.2397 1 1
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0176 0.0707 0.0695
Loa Loa (eye worm) hypothetical protein 0.0036 0.0122 0.0109
Brugia malayi Pax transcription activation domain interacting protein 0.001 0.0013 0.0002
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0014 0.0031 0.0519
Leishmania major DNA polymerase kappa, putative 0.0022 0.0066 0.0718
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.001 0.0015 0.0001
Schistosoma mansoni hypothetical protein 0.0176 0.0707 0.0695
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0048 0.0173 0.2301
Leishmania major 4-coumarate:coa ligase-like protein 0.0048 0.0173 0.2609
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0059 0.022 0.0345
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0813 0.3373 0.5569
Echinococcus granulosus histone lysine methyltransferase setb 0.0062 0.0233 0.0365
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0091 0.0354 0.0566
Trypanosoma brucei DNA polymerase IV, putative 0.0037 0.0125 0.3288
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0013 0.0025 0.0045
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0044 0.0155 0.0766
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0095 0.0082
Schistosoma mansoni cpg binding protein 0.0031 0.0102 0.009
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0048 0.0174 0.0164
Brugia malayi Hemopexin family protein 0.0177 0.0711 0.0701
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0014 0.0031 0.0489
Wolbachia endosymbiont of Brugia malayi extracellular metallopeptidase 0.0635 0.2627 1
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0013 0.0025 0.0343
Schistosoma mansoni acetyl-CoA synthetase 0.0014 0.0031 0.0019
Brugia malayi AMP-binding enzyme family protein 0.0048 0.0173 0.0162
Echinococcus granulosus matrix metallopeptidase 7 M10 family 0.0453 0.1867 0.3074
Echinococcus multilocularis muscleblind protein 1 0.0153 0.0611 0.0992
Loa Loa (eye worm) hypothetical protein 0.0036 0.0122 0.0109
Brugia malayi Inositol-1 0.0038 0.013 0.0119
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0044 0.0158 0.2499
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.001 0.0015 0.0001
Schistosoma mansoni hypothetical protein 0.0041 0.0143 0.0131
Trichomonas vaginalis glucosylceramidase, putative 0.017 0.0683 0.3381
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0013 0.0067
Loa Loa (eye worm) acetyltransferase 0.0151 0.0604 0.0591

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) > 250 uM Inhibition of human DNA topoisomerase 2-mediated relaxation of supercoiled DNA by gel electrophoresis ChEMBL. 20371180
IC50 (binding) > 250 uM Inhibition of human DNA topoisomerase 1-mediated relaxation of supercoiled DNA by gel electrophoresis ChEMBL. 20371180

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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