Detailed information for compound 1136960

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 434.122 | Formula: C7H17O15P3
  • H donors: 9 H acceptors: 12 LogP: -6.25 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 3
  • SMILES: OCC1C(OP(=O)(O)O)C(OP(=O)(O)O)C(C(C1O)OP(=O)(O)O)O
  • InChi: 1S/C7H17O15P3/c8-1-2-3(9)6(21-24(14,15)16)4(10)7(22-25(17,18)19)5(2)20-23(11,12)13/h2-10H,1H2,(H2,11,12,13)(H2,14,15,16)(H2,17,18,19)
  • InChiKey: QCSGZYRCELECJV-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Inositol 1,4,5-trisphosphate binding protein Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132301 All targets in OG5_132301
Schistosoma mansoni phospholipase C-like protein 2 plc-L2 Get druggable targets OG5_132301 All targets in OG5_132301
Schistosoma japonicum Inactive phospholipase C-like protein 2, putative Get druggable targets OG5_132301 All targets in OG5_132301
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132301 All targets in OG5_132301
Onchocerca volvulus Get druggable targets OG5_132301 All targets in OG5_132301
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi geranylgeranyl pyrophosphate synthetase 0.1341 0.3355 0.3355
Brugia malayi mbt repeat family protein 0.0053 0.007 0.007
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0035 0.0031
Trypanosoma cruzi solanesyl-diphosphate synthase, putative 0.1063 0.2647 0.2644
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0067 0.0106 0.0095
Schistosoma mansoni aldehyde dehydrogenase 0.0067 0.0106 0.0095
Echinococcus multilocularis polycomb protein SCMH1 0.0053 0.007 0.0058
Toxoplasma gondii thioredoxin reductase 0.0052 0.0069 0.0065
Loa Loa (eye worm) phosphatidylinositol-specific phospholipase C 0.0027 0.0004 0.0004
Brugia malayi Glycosyl hydrolases family 31 protein 0.0175 0.0382 0.0382
Brugia malayi glutathione reductase 0.0052 0.0069 0.0069
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0039 0.0035 0.0035
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0053 0.007 0.3094
Echinococcus granulosus neutral alpha glucosidase AB 0.0039 0.0035 0.0023
Trichomonas vaginalis conserved hypothetical protein 0.0116 0.0233 0.0199
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.006 0.0088 0.0077
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0116 0.0233 0.0233
Echinococcus multilocularis tar DNA binding protein 0.007 0.0114 0.0102
Echinococcus multilocularis lysosomal alpha glucosidase 0.0175 0.0382 0.0371
Treponema pallidum octaprenyl-diphosphate synthase 0.1341 0.3355 0.5
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0245 0.0561 0.055
Mycobacterium ulcerans polyprenyl synthetase IdsB 0.1063 0.2647 0.2568
Loa Loa (eye worm) hypothetical protein 0.0107 0.0208 0.0208
Echinococcus multilocularis geranylgeranyl pyrophosphate synthase 0.1341 0.3355 0.3347
Mycobacterium ulcerans geranylgeranyl pyrophosphate synthase 0.3947 1 1
Onchocerca volvulus 0.0104 0.02 1
Plasmodium falciparum thioredoxin reductase 0.0052 0.0069 0.0069
Toxoplasma gondii polyprenyl synthetase superfamily protein 0.3947 1 1
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0067 0.0106 0.0038
Echinococcus multilocularis geminin 0.0187 0.0412 0.0401
Trypanosoma brucei farnesyl pyrophosphate synthase 0.3947 1 1
Echinococcus granulosus prenyl decaprenyl diphosphate synthase 0.1063 0.2647 0.2639
Schistosoma mansoni glutathione synthetase 0.1063 0.2647 0.2639
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0027 0.0004 0.0004
Trichomonas vaginalis 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative 0.0133 0.0274 0.024
Trypanosoma cruzi 3-hydroxy-3-methylglutaryl-CoA reductase, putative 0.0283 0.0657 0.0653
Loa Loa (eye worm) hypothetical protein 0.0053 0.007 0.007
Echinococcus granulosus 1-Phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-4 0.006 0.009 0.0078
Brugia malayi Polyprenyl synthetase family protein 0.1063 0.2647 0.2647
Schistosoma mansoni hypothetical protein 0.0187 0.0412 0.0401
Schistosoma mansoni tar DNA-binding protein 0.007 0.0114 0.0102
Loa Loa (eye worm) hypothetical protein 0.0508 0.123 0.123
Mycobacterium leprae PROBABLE POLYPRENYL-DIPHOSPHATE SYNTHASE GRCC1 (POLYPRENYL PYROPHOSPHATE SYNTHETASE) 0.1063 0.2647 1
Trichomonas vaginalis geranylgeranyl diphosphate synthase, putative 0.3947 1 1
Schistosoma mansoni trans-prenyltransferase 0.1063 0.2647 0.2639
Echinococcus granulosus geminin 0.0187 0.0412 0.0401
Loa Loa (eye worm) geranylgeranyl pyrophosphate synthetase 0.1341 0.3355 0.3355
Brugia malayi Hydroxymethylglutaryl-coenzyme A reductase family protein 0.0283 0.0657 0.0657
Echinococcus multilocularis farnesyl pyrophosphate synthase 0.3947 1 1
Onchocerca volvulus 0.006 0.009 0.4145
Trypanosoma brucei trypanothione reductase 0.0052 0.0069 0.0065
Leishmania major farnesyl pyrophosphate synthase 0.3947 1 1
Trichomonas vaginalis geranylgeranyl pyrophosphate synthase, putative 0.3947 1 1
Schistosoma mansoni tar DNA-binding protein 0.007 0.0114 0.0102
Echinococcus multilocularis sterol regulatory element binding protein 0.0116 0.0233 0.0221
Loa Loa (eye worm) thioredoxin reductase 0.0052 0.0069 0.0069
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0132 0.0273 0.0205
Trypanosoma cruzi farnesyl pyrophosphate synthase 0.3947 1 1
Echinococcus multilocularis protein dispatched 1 0.0116 0.0233 0.0221
Schistosoma mansoni hypothetical protein 0.0104 0.02 0.0188
Schistosoma mansoni farnesyl pyrophosphate synthase 0.3947 1 1
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0067 0.0106 0.0095
Echinococcus multilocularis neutral alpha glucosidase AB 0.0039 0.0035 0.0023
Loa Loa (eye worm) hypothetical protein 0.0116 0.0233 0.0233
Schistosoma mansoni tar DNA-binding protein 0.007 0.0114 0.0102
Brugia malayi Variant SH3 domain containing protein 0.0027 0.0004 0.0004
Brugia malayi Intermediate filament tail domain containing protein 0.003 0.0012 0.0012
Echinococcus granulosus hydroxymethylglutaryl coenzyme A reductase 0.0283 0.0657 0.0646
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0245 0.0561 0.055
Brugia malayi Thioredoxin reductase 0.0052 0.0069 0.0069
Loa Loa (eye worm) intermediate filament protein 0.003 0.0012 0.0012
Trypanosoma brucei inositol 1,4,5-trisphosphate receptor 0.0111 0.0218 0.0214
Echinococcus granulosus Protein patched homolog 1 0.0116 0.0233 0.0221
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0132 0.0273 0.0205
Entamoeba histolytica geranylgeranyl pyrophosphate synthase, putative 0.1063 0.2647 1
Brugia malayi intermediate filament protein 0.003 0.0012 0.0012
Echinococcus granulosus Niemann Pick C1 protein 0.0116 0.0233 0.0221
Loa Loa (eye worm) hypothetical protein 0.003 0.0012 0.0012
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0207 0.0464 0.0453
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0119 0.0239 0.0171
Chlamydia trachomatis geranylgeranyl pyrophosphate synthase 0.1063 0.2647 0.5
Loa Loa (eye worm) hypothetical protein 0.006 0.0088 0.0088
Mycobacterium tuberculosis Probable polyprenyl-diphosphate synthase GrcC2 (polyprenyl pyrophosphate synthetase) 0.1063 0.2647 0.2596
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0245 0.0561 0.055
Echinococcus granulosus SAM and MBT domain containing protein 0.0053 0.007 0.0058
Loa Loa (eye worm) mbt repeat family protein 0.0053 0.007 0.007
Schistosoma mansoni alpha-glucosidase 0.0151 0.032 0.0309
Schistosoma mansoni hydroxymethylglutaryl-CoA reductase (NADPH) 0.0283 0.0657 0.0646
Loa Loa (eye worm) hypothetical protein 0.0029 0.001 0.001
Loa Loa (eye worm) MBCTL1 0.006 0.0088 0.0088
Loa Loa (eye worm) polyprenyl synthetase 0.1063 0.2647 0.2647
Loa Loa (eye worm) RNA binding protein 0.007 0.0114 0.0114
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.1663 0.4177 0.417
Brugia malayi Glycosyl hydrolases family 31 protein 0.0039 0.0035 0.0035
Trypanosoma brucei 3-hydroxy-3-methylglutaryl-CoA reductase, putative 0.0283 0.0657 0.0653
Trypanosoma brucei solanesyl-diphosphate synthase, putative 0.1063 0.2647 0.2644
Schistosoma mansoni geranylgeranyl pyrophosphate synthase 0.1341 0.3355 0.3347
Echinococcus granulosus tar DNA binding protein 0.007 0.0114 0.0102
Plasmodium falciparum geranylgeranyl pyrophosphate synthase, putative 0.3947 1 1
Brugia malayi hypothetical protein 0.0508 0.123 0.123
Plasmodium vivax octaprenyl pyrophosphate synthase, putative 0.1063 0.2647 0.2647
Trypanosoma cruzi polyprenyl synthase, putative 0.1341 0.3355 0.3352
Loa Loa (eye worm) hypothetical protein 0.0081 0.0141 0.0141
Leishmania major alpha glucosidase II subunit, putative 0.0039 0.0035 0.0035
Trypanosoma cruzi polyprenyl synthase, putative 0.1341 0.3355 0.3352
Toxoplasma gondii polyprenyl synthetase superfamily protein 0.1063 0.2647 0.2644
Loa Loa (eye worm) ryanodine receptor 0.0035 0.0026 0.0026
Echinococcus multilocularis hydroxymethylglutaryl coenzyme A reductase 0.0283 0.0657 0.0646
Loa Loa (eye worm) polyprenyl synthetase 0.3947 1 1
Schistosoma mansoni survival motor neuron protein 0.0104 0.02 0.0188
Schistosoma mansoni patched 1 0.0116 0.0233 0.0221
Loa Loa (eye worm) hypothetical protein 0.0094 0.0175 0.0175
Echinococcus multilocularis 1 phosphatidylinositol 4,5 bisphosphate 0.006 0.009 0.0078
Brugia malayi TAR-binding protein 0.007 0.0114 0.0114
Leishmania major 3-hydroxy-3-methylglutaryl-CoA reductase 0.0283 0.0657 0.0657
Brugia malayi CHE-14 protein 0.0116 0.0233 0.0233
Echinococcus multilocularis survival motor neuron protein 1 0.0508 0.123 0.122
Trypanosoma cruzi 3-hydroxy-3-methylglutaryl-CoA reductase 0.0283 0.0657 0.0653
Schistosoma mansoni hypothetical protein 0.0319 0.075 0.074
Schistosoma mansoni phospholipase C-like protein 2 plc-L2 0.0044 0.0048 0.0037
Brugia malayi phospholipase C homolog 0.0044 0.0048 0.0048
Trichomonas vaginalis 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative 0.0133 0.0274 0.024
Trypanosoma cruzi farnesyl pyrophosphate synthase, putative 0.3947 1 1
Trichomonas vaginalis geranylgeranyl pyrophosphate synthase, putative 0.3947 1 1
Trichomonas vaginalis 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative 0.0133 0.0274 0.024
Echinococcus granulosus thioredoxin glutathione reductase 0.0052 0.0069 0.0057
Brugia malayi Phosphatidylinositol-specific phospholipase C, X domain containing protein 0.0027 0.0004 0.0004
Brugia malayi 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta 4 0.0059 0.0086 0.0086
Echinococcus multilocularis prenyl (decaprenyl) diphosphate synthase 0.1063 0.2647 0.2639
Echinococcus granulosus ryanodine receptor 44f 0.0073 0.0122 0.011
Schistosoma mansoni ryanodine receptor 1 skeletal muscle 0.0035 0.0026 0.0015
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.003 0.0012 0.0012
Schistosoma mansoni phospholipase C-like protein 2 plc-L2 0.0097 0.0182 0.0171
Brugia malayi Ryanodine Receptor TM 4-6 family protein 0.0131 0.0271 0.0271
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.007 0.0114 0.0114
Entamoeba histolytica bifunctional short chain isoprenyl diphosphate synthase, putative 0.1063 0.2647 1
Trypanosoma brucei glucosidase, putative 0.0039 0.0035 0.0031
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0245 0.0561 0.055
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0039 0.0035 0.0031
Echinococcus multilocularis thioredoxin glutathione reductase 0.0052 0.0069 0.0057
Trypanosoma cruzi solanesyl-diphosphate synthase 0.1063 0.2647 0.2644
Mycobacterium ulcerans hydroxymethylglutaryl-coenzyme a (HMG-CoA) reductase 0.0283 0.0657 0.0556
Wolbachia endosymbiont of Brugia malayi geranylgeranyl pyrophosphate synthase 0.1063 0.2647 0.5
Plasmodium falciparum glutathione reductase 0.0052 0.0069 0.0069
Mycobacterium tuberculosis Probable multifunctional geranylgeranyl pyrophosphate synthetase IdsA1 (GGPP synthetase) (ggppsase) (geranylgeranyl diphosphate 0.1063 0.2647 0.2596
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0248 0.0569 0.0569
Schistosoma mansoni sex comb on midleg homolog 0.0053 0.007 0.0058
Echinococcus multilocularis ryanodine receptor 44f 0.0094 0.0175 0.0164
Echinococcus multilocularis lysosomal alpha glucosidase 0.0175 0.0382 0.0371
Schistosoma mansoni aldehyde dehydrogenase 0.0067 0.0106 0.0095
Brugia malayi RNA binding protein 0.007 0.0114 0.0114
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0132 0.0273 0.014
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0245 0.0561 0.0561
Echinococcus granulosus lysosomal alpha glucosidase 0.0175 0.0382 0.0371
Echinococcus multilocularis decaprenyl diphosphate synthase subunit 1 0.1063 0.2647 0.2639
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0067 0.0106 0.0106
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.006 0.0088 0.0088
Onchocerca volvulus 0.0101 0.0194 0.9687
Trypanosoma cruzi inositol 1,4,5-trisphosphate receptor, putative 0.0111 0.0218 0.0214
Loa Loa (eye worm) hypothetical protein 0.0283 0.0657 0.0657
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0245 0.0561 0.055
Echinococcus granulosus ryanodine receptor 44f 0.0094 0.0175 0.0164
Schistosoma mansoni ryanodine receptor related 0.0131 0.0271 0.0259
Echinococcus multilocularis SAM and MBT domain containing protein 0.0053 0.007 0.0058
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0035 0.0031
Echinococcus multilocularis ryanodine receptor 44f 0.0073 0.0122 0.011
Trypanosoma cruzi solanesyl-diphosphate synthase, putative 0.1063 0.2647 0.2644
Brugia malayi follicle stimulating hormone receptor 0.0248 0.0569 0.0569
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.006 0.0088 0.0077
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0119 0.0239 0.0171
Leishmania major solanesyl-diphosphate synthase, putative 0.1063 0.2647 0.2647
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0104 0.02 0.02
Mycobacterium tuberculosis Probable geranylgeranyl pyrophosphate synthetase IdsA2 (ggppsase) (GGPP synthetase) (geranylgeranyl diphosphate synthase) 0.3947 1 1
Loa Loa (eye worm) glutathione reductase 0.0052 0.0069 0.0069
Echinococcus granulosus histone acetyltransferase MYST2 0.006 0.0088 0.0077
Plasmodium falciparum octaprenyl pyrophosphate synthase 0.1063 0.2647 0.2647
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0053 0.007 0.0058
Loa Loa (eye worm) hypothetical protein 0.0128 0.0262 0.0262
Trypanosoma cruzi trypanothione reductase, putative 0.0052 0.0069 0.0065
Mycobacterium tuberculosis Probable reductase 0.0119 0.0239 0.0171
Entamoeba histolytica geranylgeranyl pyrophosphate synthetase, putative 0.1063 0.2647 1
Echinococcus granulosus sterol regulatory element binding protein 0.0116 0.0233 0.0221
Loa Loa (eye worm) hypothetical protein 0.0141 0.0295 0.0295
Plasmodium vivax geranylgeranyl pyrophosphate synthase 0.3947 1 1
Schistosoma mansoni alpha-glucosidase 0.0151 0.032 0.0309
Echinococcus granulosus geranylgeranyl pyrophosphate synthase 0.1341 0.3355 0.3347
Schistosoma mansoni hypothetical protein 0.0187 0.0412 0.0401
Mycobacterium ulcerans geranylgeranyl pyrophosphate synthase 0.3947 1 1
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0175 0.0382 0.0382
Echinococcus multilocularis histone acetyltransferase MYST2 0.006 0.0088 0.0077
Echinococcus granulosus polycomb protein SCMH1 0.0053 0.007 0.0058
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0245 0.0561 0.055
Echinococcus granulosus survival motor neuron protein 1 0.0508 0.123 0.122
Leishmania major trypanothione reductase 0.0052 0.0069 0.0069
Brugia malayi mbt repeat family protein 0.0053 0.007 0.007
Mycobacterium tuberculosis Probable dehydrogenase 0.0119 0.0239 0.0171
Leishmania major hypothetical protein, conserved 0.0075 0.0128 0.0128
Schistosoma mansoni phospholipase C beta 0.0059 0.0086 0.0074
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0245 0.0561 0.055
Mycobacterium ulcerans polyprenyl diphosphate synthetase, GrcC1 0.1063 0.2647 0.2568
Plasmodium vivax thioredoxin reductase, putative 0.0052 0.0069 0.0069
Loa Loa (eye worm) Plcb4 protein 0.0059 0.0086 0.0086
Schistosoma mansoni myelin transcription factor 1 myt1 0.006 0.0088 0.0077
Loa Loa (eye worm) TAR-binding protein 0.007 0.0114 0.0114
Onchocerca volvulus 0.0053 0.007 0.3094
Plasmodium vivax glutathione reductase, putative 0.0052 0.0069 0.0069
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0119 0.0239 0.0171
Brugia malayi RNA recognition motif domain containing protein 0.007 0.0114 0.0114
Echinococcus multilocularis Niemann Pick C1 protein 0.0116 0.0233 0.0221
Schistosoma mansoni inositol 145-trisphosphate receptor 0.0107 0.0208 0.0197
Giardia lamblia Farnesyl diphosphate synthase 0.3947 1 1
Mycobacterium tuberculosis Probable oxidoreductase 0.0132 0.0273 0.0205
Echinococcus multilocularis protein patched 0.0116 0.0233 0.0221
Loa Loa (eye worm) hypothetical protein 0.0125 0.0256 0.0256
Onchocerca volvulus 0.0081 0.0141 0.6893
Mycobacterium tuberculosis Possible polyprenyl synthetase IdsB (polyprenyl transferase) (polyprenyl diphosphate synthase) 0.1063 0.2647 0.2596
Schistosoma mansoni tar DNA-binding protein 0.007 0.0114 0.0102
Leishmania major polyprenyl synthase, putative 0.1341 0.3355 0.3355
Toxoplasma gondii aldehyde dehydrogenase 0.0067 0.0106 0.0103
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0245 0.0561 0.0561
Schistosoma mansoni tar DNA-binding protein 0.007 0.0114 0.0102
Schistosoma mansoni alpha glucosidase 0.0039 0.0035 0.0023
Brugia malayi cation channel family protein 0.0201 0.0448 0.0448
Wolbachia endosymbiont of Brugia malayi geranylgeranyl pyrophosphate synthase 0.1063 0.2647 0.5
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0207 0.0464 0.0453
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0119 0.0239 0.0171
Echinococcus granulosus farnesyl pyrophosphate synthase 0.3947 1 1
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0116 0.0233 0.0221
Onchocerca volvulus 0.006 0.009 0.4145
Leishmania major phospholipase c-like protein 0.0027 0.0004 0.0004
Schistosoma mansoni sex comb on midleg homolog 0.0053 0.007 0.0058
Echinococcus granulosus decaprenyl diphosphate synthase subunit 1 0.1063 0.2647 0.2639
Schistosoma mansoni inositol 145-trisphosphate receptor 0.0163 0.0352 0.0341
Loa Loa (eye worm) hypothetical protein 0.006 0.009 0.009

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 0.027 uM Compound was tested for inhibition of specific [3H]Ins(1,4,5)P3 binding to Inositol 1,4,5-trisphosphate receptor in rat cerebellar membranes. ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.