Detailed information for compound 1155445

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 505.501 | Formula: C24H32N3O7P
  • H donors: 5 H acceptors: 6 LogP: 2.62 Rotable bonds: 16
    Rule of 5 violations (Lipinski): 2
  • SMILES: O=C(NCP(=O)(N[C@H](C(=O)N[C@H](C(=O)O)Cc1ccccc1)CC(C)C)O)OCc1ccccc1
  • InChi: 1S/C24H32N3O7P/c1-17(2)13-20(22(28)26-21(23(29)30)14-18-9-5-3-6-10-18)27-35(32,33)16-25-24(31)34-15-19-11-7-4-8-12-19/h3-12,17,20-21H,13-16H2,1-2H3,(H,25,31)(H,26,28)(H,29,30)(H2,27,32,33)/t20-,21-/m0/s1
  • InChiKey: LSBJYKCMZGPGPG-SFTDATJTSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Bacillus thermoproteolyticus Thermolysin Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus lamin 0.0027 0.0183 0.0182
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0032 0.0235 0.0233
Echinococcus multilocularis smad 0.0018 0.0084 0.0083
Schistosoma mansoni hypothetical protein 0.043 0.4243 1
Echinococcus multilocularis replication factor c subunit 1 0.001 0.0011 0.0009
Trypanosoma brucei DNA polymerase eta, putative 0.002 0.0112 0.2159
Trichomonas vaginalis CMGC family protein kinase 0.0057 0.0479 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0392 0.0901
Schistosoma mansoni hypothetical protein 0.0067 0.0585 0.1358
Trichomonas vaginalis CMGC family protein kinase 0.0057 0.0479 1
Schistosoma mansoni hypothetical protein 0.0049 0.04 0.0921
Loa Loa (eye worm) MH1 domain-containing protein 0.0018 0.0084 0.0183
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.002 0.0112 0.1292
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0112 0.0243
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0048 0.0392 0.0855
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0032 0.0235 0.0233
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0015 0.0057 0.3343
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0112 0.2159
Schistosoma mansoni DNA polymerase eta 0.002 0.0112 0.0239
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0112 0.2159
Mycobacterium leprae putative cytochrome p450 0.0015 0.0057 1
Schistosoma mansoni cytochrome P450 0.0015 0.0057 0.011
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.0172 0.3408
Leishmania major cytochrome p450-like protein 0.0024 0.015 0.2202
Brugia malayi MH1 domain containing protein 0.0018 0.0084 0.0183
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0015 0.0057 0.0996
Echinococcus granulosus nibrin 0.001 0.0011 0.0009
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0055 0.012
Brugia malayi MH2 domain containing protein 0.0018 0.0084 0.0183
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0015 0.0057 0.3343
Echinococcus granulosus mitogen activated protein kinase 3 0.0057 0.0479 0.0478
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0032 0.0235 1
Onchocerca volvulus 0.0027 0.0183 0.0377
Brugia malayi CXXC zinc finger family protein 0.003 0.0212 0.0461
Toxoplasma gondii histone lysine methyltransferase SET1 0.0057 0.0484 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.0322 0.0703
Brugia malayi hypothetical protein 0.001 0.0011 0.0023
Schistosoma mansoni lamin 0.0027 0.0183 0.0407
Echinococcus multilocularis musashi 0.0027 0.0183 0.0182
Schistosoma mansoni hypothetical protein 0.0067 0.0585 0.1358
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0112 0.2159
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0015 0.0057 0.3343
Brugia malayi DKFZp564C0469 protein 0.001 0.0011 0.0023
Schistosoma mansoni hypothetical protein 0.0037 0.0285 0.0648
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0032 0.0235 0.4782
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0212 0.205 0.4473
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0032 0.0235 0.0529
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.002 0.0112 0.0239
Brugia malayi cytoplasmic intermediate filament protein 0.0015 0.0055 0.0119
Brugia malayi latrophilin 2 splice variant baaae 0.0145 0.1372 0.2993
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0112 0.2159
Echinococcus multilocularis mothers against decapentaplegic 5 0.0018 0.0084 0.0083
Loa Loa (eye worm) cytochrome P450 family protein 0.0024 0.015 0.0327
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0057 0.0479 0.1045
Onchocerca volvulus 0.0027 0.0183 0.0377
Loa Loa (eye worm) hypothetical protein 0.0374 0.3676 0.8019
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.002 0.0112 0.0244
Echinococcus granulosus intermediate filament protein 0.0027 0.0183 0.0182
Echinococcus multilocularis lamin 0.0027 0.0183 0.0182
Echinococcus granulosus TGF beta signal transducer SmadC 0.0018 0.0084 0.0083
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0041 0.0322 0.0321
Brugia malayi MH1 domain containing protein 0.001 0.0005 0.001
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0112 0.2159
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0041 0.0322 0.6652
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0057 0.0479 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0011 0.0023
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0228 0.2211 0.221
Chlamydia trachomatis DNA ligase 0.001 0.0011 0.5
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0392 0.0901
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0112 0.0243
Echinococcus granulosus lamin dm0 0.0027 0.0183 0.0182
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0057 0.0479 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0048 0.0392 0.0855
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0015 0.0057 0.3343
Loa Loa (eye worm) hypothetical protein 0.001 0.0011 0.0023
Echinococcus granulosus ubiquitin specific protease 41 0.0041 0.0322 0.0321
Brugia malayi hypothetical protein 0.0026 0.0172 0.0375
Loa Loa (eye worm) hypothetical protein 0.0026 0.0172 0.0375
Loa Loa (eye worm) hypothetical protein 0.0145 0.1372 0.2993
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0172 0.7202
Brugia malayi hypothetical protein 0.001 0.0011 0.0023
Giardia lamblia DINP protein human, muc B family 0.002 0.0112 0.2159
Mycobacterium tuberculosis Possible exported protein 0.0612 0.6075 1
Echinococcus multilocularis dna polymerase kappa 0.002 0.0112 0.011
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0018 0.0084 0.0083
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0228 0.2211 0.221
Loa Loa (eye worm) MH2 domain-containing protein 0.0018 0.0084 0.0183
Brugia malayi hypothetical protein 0.0037 0.0285 0.0622
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0032 0.0235 0.4782
Entamoeba histolytica hypothetical protein 0.0037 0.0285 0.8807
Brugia malayi cytochrome P450 0.0015 0.0057 0.0125
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0032 0.0235 1
Brugia malayi MH2 domain containing protein 0.0257 0.2501 0.5457
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0057 0.0479 1
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0015 0.0057 0.0996
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.0172 0.7202
Brugia malayi Calcitonin receptor-like protein seb-1 0.0212 0.205 0.4473
Onchocerca volvulus 0.0049 0.04 0.0852
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0112 0.2159
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0041 0.0322 0.0321
Loa Loa (eye worm) hypothetical protein 0.0027 0.0178 0.0388
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0041 0.0322 0.0321
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0112 0.7251
Onchocerca volvulus 0.003 0.0212 0.044
Entamoeba histolytica deoxycytidyl transferase, putative 0.002 0.0112 0.3246
Loa Loa (eye worm) isocitrate dehydrogenase 0.0032 0.0235 0.0512
Echinococcus granulosus dna polymerase eta 0.002 0.0112 0.011
Schistosoma mansoni lamin 0.0027 0.0183 0.0407
Schistosoma mansoni cpg binding protein 0.003 0.0212 0.0475
Brugia malayi MH2 domain containing protein 0.0018 0.0084 0.0183
Echinococcus granulosus survival motor neuron protein 1 0.024 0.2324 0.2323
Loa Loa (eye worm) hypothetical protein 0.001 0.0005 0.0011
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0024 0.015 1
Schistosoma mansoni survival motor neuron protein 0.0049 0.04 0.0921
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0374 0.3676 0.8019
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0057 0.0479 1
Schistosoma mansoni hypothetical protein 0.0348 0.3419 0.8053
Echinococcus multilocularis lamin dm0 0.0027 0.0183 0.0182
Schistosoma mansoni terminal deoxycytidyl transferase 0.002 0.0112 0.0239
Brugia malayi Isocitrate dehydrogenase 0.0032 0.0235 0.0512
Echinococcus multilocularis ubiquitin specific protease 41 0.0041 0.0322 0.0321
Loa Loa (eye worm) hypothetical protein 0.0013 0.004 0.0088
Loa Loa (eye worm) transcription factor SMAD2 0.0257 0.2501 0.5457
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0032 0.0235 0.4782
Echinococcus multilocularis Smad4 0.0018 0.0084 0.0083
Trypanosoma cruzi DNA polymerase eta, putative 0.002 0.0112 0.2159
Giardia lamblia Kinase, CMGC MAPK 0.0057 0.0479 1
Echinococcus granulosus cpg binding protein 0.0032 0.0229 0.0228
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0015 0.0057 0.0996
Schistosoma mansoni hypothetical protein 0.0145 0.1372 0.3217
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0112 0.2159
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0015 0.0057 0.3343
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.0285 0.0648
Brugia malayi Cytochrome P450 family protein 0.0024 0.015 0.0327
Loa Loa (eye worm) hypothetical protein 0.0067 0.0585 0.1277
Leishmania major DNA polymerase eta, putative 0.002 0.0112 0.1292
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0172 0.3444
Onchocerca volvulus 0.0464 0.4584 1
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0183 0.0399
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0001 0.0003
Trypanosoma brucei protein kinase, putative 0.0057 0.0479 1
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0049 0.04 0.0873
Trypanosoma brucei unspecified product 0.0014 0.0048 0.0804
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0057 0.0479 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0064 0.0553 0.1281
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0041 0.0322 0.6652
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0112 0.2159
Loa Loa (eye worm) hypothetical protein 0.0013 0.0035 0.0077
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0112 0.2159
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0012 0.0026 0.0025
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.004 0.0039
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0048 0.0392 0.0391
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0041 0.0322 0.6652
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0015 0.0057 0.3343
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0112 0.2159
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0172 0.3444
Trichomonas vaginalis CMGC family protein kinase 0.0057 0.0479 1
Echinococcus granulosus dnaJ subfamily B 0.043 0.4243 0.4242
Brugia malayi Cytochrome P450 family protein 0.0015 0.0057 0.0125
Echinococcus granulosus neuropeptide receptor A26 0.1001 1 1
Echinococcus granulosus geminin 0.0348 0.3419 0.3418
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0048 0.0804
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0041 0.0322 0.0736
Echinococcus granulosus Smad4 0.0018 0.0084 0.0083
Schistosoma mansoni smad 0.0018 0.0084 0.0173
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0015 0.0057 0.0996
Brugia malayi hypothetical protein 0.024 0.2324 0.5071
Wolbachia endosymbiont of Brugia malayi NAD-dependent DNA ligase, Lig 0.001 0.0011 0.5
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0015 0.0057 0.3343
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0112 0.2159
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0015 0.0057 0.3343
Echinococcus granulosus mothers against decapentaplegic 5 0.0018 0.0084 0.0083
Brugia malayi hypothetical protein 0.0464 0.4584 1
Loa Loa (eye worm) cytochrome P450 family protein 0.0024 0.015 0.0327
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0112 0.2159
Echinococcus granulosus mitogen activated protein kinase 0.0057 0.0479 0.0478
Echinococcus multilocularis cpg binding protein 0.0032 0.0229 0.0228
Loa Loa (eye worm) hypothetical protein 0.001 0.0011 0.0023
Toxoplasma gondii isocitrate dehydrogenase 0.0032 0.0235 0.4733
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0041 0.0322 0.0736
Schistosoma mansoni hypothetical protein 0.0012 0.0026 0.0036
Echinococcus granulosus smad 0.0018 0.0084 0.0083
Brugia malayi Cytochrome P450 family protein 0.0055 0.0462 0.1007
Brugia malayi hypothetical protein 0.0017 0.0078 0.017
Mycobacterium leprae Conserved hypothetical protein 0.0015 0.0057 1
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0322 0.6652
Schistosoma mansoni cpg binding protein 0.0032 0.0229 0.0516
Schistosoma mansoni serine/threonine protein kinase 0.0057 0.0479 0.1107
Toxoplasma gondii cytochrome p450 superfamily protein 0.0015 0.0057 0.0985
Schistosoma mansoni Smad4 0.0018 0.0084 0.0173
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0015 0.0057 0.3343
Loa Loa (eye worm) CYP4Cod1 0.0024 0.015 0.0327
Schistosoma mansoni smad1 5 8 and 0.0018 0.0084 0.0173
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0032 0.0235 0.0233
Brugia malayi Latrophilin receptor protein 2 0.0067 0.0585 0.1276
Schistosoma mansoni hypothetical protein 0.0348 0.3419 0.8053
Echinococcus multilocularis neuropeptide receptor A26 0.1001 1 1
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0112 0.7251
Trypanosoma brucei unspecified product 0.002 0.0112 0.2159
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0041 0.0322 0.6652
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.002 0.0112 0.011
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0057 0.0479 0.9898
Mycobacterium tuberculosis Conserved hypothetical protein 0.002 0.0112 0.0091
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0032 0.0235 0.0233
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0067 0.0585 0.1276
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0015 0.0057 0.3343
Entamoeba histolytica hypothetical protein 0.0037 0.0285 0.8807
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.002 0.0112 0.011
Brugia malayi Cytochrome P450 family protein 0.0024 0.015 0.0327
Schistosoma mansoni smad1 5 8 and 0.0018 0.0084 0.0173
Loa Loa (eye worm) latrophilin receptor protein 2 0.0067 0.0585 0.1277
Loa Loa (eye worm) hypothetical protein 0.024 0.2324 0.5071
Schistosoma mansoni hypothetical protein 0.0015 0.0057 0.011
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0392 0.0901
Schistosoma mansoni hypothetical protein 0.0067 0.0585 0.1358
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.002 0.0112 0.0091
Loa Loa (eye worm) hypothetical protein 0.001 0.0011 0.0023
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0041 0.0322 0.0703
Schistosoma mansoni smad1 5 8 and 0.0018 0.0084 0.0173
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.004 0.0039
Echinococcus multilocularis mitogen activated protein kinase 0.0057 0.0479 0.0478
Trichomonas vaginalis DNA polymerase eta, putative 0.002 0.0112 0.2159
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0015 0.0057 0.3343
Echinococcus multilocularis mitogen activated protein kinase 3 0.0057 0.0479 0.0478
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0015 0.0057 0.3343
Trypanosoma brucei cytochrome P450, putative 0.0024 0.015 0.2978
Schistosoma mansoni intermediate filament proteins 0.0027 0.0183 0.0407
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0057 0.0479 1
Echinococcus multilocularis nibrin 0.001 0.0011 0.0009
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0041 0.0322 0.0321
Echinococcus granulosus GPCR family 2 0.0067 0.0585 0.0584
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.0285 0.0284
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0067 0.0585 0.0584
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0032 0.0235 0.0233
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.0172 0.3444
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0032 0.0235 0.4782
Loa Loa (eye worm) nuclear factor I 0.001 0.0005 0.0011
Loa Loa (eye worm) hypothetical protein 0.001 0.0011 0.0023
Entamoeba histolytica hypothetical protein 0.0037 0.0285 0.8807
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0012 0.0026 0.0025
Brugia malayi intermediate filament protein 0.0027 0.0183 0.0399
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0048 0.0804
Loa Loa (eye worm) cytochrome P450 0.0015 0.0057 0.0125
Echinococcus multilocularis GPCR, family 2 0.0067 0.0585 0.0584
Trypanosoma cruzi cytochrome P450, putative 0.0024 0.015 0.2978
Loa Loa (eye worm) Smad1 0.0018 0.0084 0.0183
Echinococcus granulosus replication factor c subunit 1 0.001 0.0011 0.0009
Loa Loa (eye worm) cytochrome P450 family protein 0.0055 0.0462 0.1007
Brugia malayi MH1 domain containing protein 0.001 0.0005 0.001
Trypanosoma cruzi cytochrome P450, putative 0.0024 0.015 0.2978
Schistosoma mansoni hypothetical protein 0.0067 0.0585 0.1358
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0048 0.0392 0.0391
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0048 0.0392 0.0391
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0041 0.0322 0.6652
Brugia malayi MH1 domain containing protein 0.0018 0.0084 0.0183
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0183 0.0399
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0041 0.0322 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0048 0.0804
Schistosoma mansoni cpg binding protein 0.0032 0.0229 0.0516
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0112 0.2159
Echinococcus multilocularis isocitrate dehydrogenase 0.0032 0.0235 0.0233
Echinococcus granulosus dna polymerase kappa 0.002 0.0112 0.011
Toxoplasma gondii isocitrate dehydrogenase 0.0032 0.0235 0.4733
Leishmania major hypothetical protein, conserved 0.0026 0.0172 0.2719
Entamoeba histolytica hypothetical protein 0.0037 0.0285 0.8807
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0041 0.0322 0.6282
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0057 0.0479 1
Brugia malayi topoisomerase 0.001 0.0011 0.0023
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0041 0.0322 0.6652
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.001 0.0011 0.0023
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0112 0.2159
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0067 0.0585 0.0584
Echinococcus multilocularis geminin 0.0348 0.3419 0.3418
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.0285 0.0284
Echinococcus multilocularis neuropeptide s receptor 0.1001 1 1
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0015 0.0057 0.3343
Loa Loa (eye worm) hypothetical protein 0.0027 0.0183 0.0399
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0032 0.0235 0.0295
Brugia malayi isocitrate dehydrogenase 0.0032 0.0235 0.0512
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0112 0.2159
Loa Loa (eye worm) hypothetical protein 0.002 0.0112 0.0244
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0015 0.0057 0.3343
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.002 0.0112 0.2159
Loa Loa (eye worm) MH2 domain-containing protein 0.0257 0.2501 0.5457
Treponema pallidum DNA ligase (lig) 0.001 0.0011 0.5
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0112 0.2159
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0032 0.0235 0.4205
Echinococcus multilocularis 0.0015 0.0057 0.0056
Echinococcus granulosus cytochrome P450 2K1 0.0015 0.0057 0.0056
Brugia malayi Pax transcription activation domain interacting protein 0.001 0.0011 0.0023
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0172 0.7202
Brugia malayi Smad1 0.0018 0.0084 0.0183
Echinococcus multilocularis dna polymerase eta 0.002 0.0112 0.011
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0015 0.0057 0.3343
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0015 0.0057 0.3343
Loa Loa (eye worm) CXXC zinc finger family protein 0.003 0.0212 0.0462
Brugia malayi MAP kinase sur-1 0.0057 0.0479 0.1045
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0018 0.0084 0.0173
Trypanosoma brucei unspecified product 0.0014 0.0048 0.0804
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0015 0.0057 0.3343
Echinococcus multilocularis survival motor neuron protein 1 0.024 0.2324 0.2323
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0015 0.0057 0.3343
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0015 0.0057 0.3343
Echinococcus multilocularis dnaJ subfamily B 0.043 0.4243 0.4242
Loa Loa (eye worm) hypothetical protein 0.0464 0.4584 1
Loa Loa (eye worm) hypothetical protein 0.0013 0.0035 0.0077
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0183 0.0399
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0112 0.2159
Leishmania major DNA polymerase kappa, putative 0.002 0.0112 0.1292
Loa Loa (eye worm) hypothetical protein 0.001 0.0011 0.0023
Trichomonas vaginalis CMGC family protein kinase 0.0057 0.0479 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0048 0.0392 0.0391
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0015 0.0057 0.3343

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 0.054 uM Inhibition of Bacillus thermoproteolyticus TLN using 2-furanacryloyl-Gly-Leu-NH2 substrate by biochemical assay ChEMBL. 25559080

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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