Detailed information for compound 1155830

Basic information

Technical information
  • TDR Targets ID: 1155830
  • Name: methyl 2-[(3-carbamimidoylphenyl)-[2-[4-(2-su lfamoylphenyl)phenyl]ethyl]amino]acetate
  • MW: 466.553 | Formula: C24H26N4O4S
  • H donors: 2 H acceptors: 3 LogP: 3.08 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: COC(=O)CN(c1cccc(c1)C(=N)N)CCc1ccc(cc1)c1ccccc1S(=O)(=O)N
  • InChi: 1S/C24H26N4O4S/c1-32-23(29)16-28(20-6-4-5-19(15-20)24(25)26)14-13-17-9-11-18(12-10-17)21-7-2-3-8-22(21)33(27,30)31/h2-12,15H,13-14,16H2,1H3,(H3,25,26)(H2,27,30,31)
  • InChiKey: LCHFBKHDAWJSLO-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-[(3-carbamimidoylphenyl)-[2-[4-(2-sulfamoylphenyl)phenyl]ethyl]amino]acetic acid methyl ester
  • 2-[(3-amidinophenyl)-[2-[4-(2-sulfamoylphenyl)phenyl]ethyl]amino]acetic acid methyl ester
  • methyl 2-[(3-carbamimidoylphenyl)-[2-[4-(2-sulfamoylphenyl)phenyl]ethyl]amino]ethanoate

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis mothers against decapentaplegic 5 0.0009 0.0031 0.0032
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0009 0.0031 0.0032
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0489 0.0641
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0099 0.3007 0.312
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0018 0.034 0.0353
Trichomonas vaginalis DNA helicase recq1, putative 0.0024 0.0536 0.0703
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0311 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.034 0.0446
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0099 0.3007 0.312
Toxoplasma gondii FATC domain-containing protein 0.0025 0.0566 0.3761
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.011 0.0165
Trichomonas vaginalis PIKK family atypical protein kinase 0.001 0.0077 0.0101
Loa Loa (eye worm) hypothetical protein 0.0011 0.011 0.0114
Leishmania major phosphatidylinositol kinase related protein, putative 0.0018 0.0341 0.018
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0056 0.1582 0.1442
Echinococcus granulosus fetal alzheimer antigen falz 0.0023 0.0489 0.0507
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0311 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.034 0.0446
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.021 0.6668 0.6919
Trypanosoma cruzi ISWI complex protein 0.0015 0.0247 0.0171
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0056 0.1582 0.1394
Schistosoma mansoni zinc finger protein 0.002 0.039 0.0405
Trichomonas vaginalis inositol monophosphatase, putative 0.0043 0.1154 0.1513
Schistosoma mansoni DNA helicase recq5 0.001 0.0067 0.007
Schistosoma mansoni DNA helicase recq1 0.001 0.0067 0.007
Echinococcus multilocularis inositol monophosphatase 1 0.0043 0.1154 0.1197
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0576 0.8527
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0023 0.0489 0.0507
Schistosoma mansoni inositol monophosphatase 0.0043 0.1154 0.1197
Schistosoma mansoni hypothetical protein 0.0048 0.1315 0.1364
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0043 0.1154 0.1006
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.034 0.0446
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0151 0.4724 0.7085
Loa Loa (eye worm) transcription factor SMAD2 0.0131 0.4054 0.4207
Echinococcus multilocularis Smad4 0.0009 0.0031 0.0032
Echinococcus granulosus GPCR family 2 0.0048 0.1315 0.1364
Leishmania major importin beta-1 subunit, putative 0.0023 0.0489 0.033
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.034 0.0446
Schistosoma mansoni hypothetical protein 0.0015 0.0247 0.0257
Brugia malayi MH1 domain containing protein 0.0009 0.0031 0.0047
Schistosoma mansoni hypothetical protein 0.0103 0.3146 0.3265
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0018 0.034 0.051
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0306 0.0317
Brugia malayi MH2 domain containing protein 0.0009 0.0031 0.0047
Loa Loa (eye worm) hypothetical protein 0.0011 0.011 0.0114
Loa Loa (eye worm) hypothetical protein 0.0048 0.1315 0.1364
Echinococcus multilocularis FTZ F1 alpha 0.0011 0.011 0.0114
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0018 0.034 0.0353
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0011 0.011 0.0165
Echinococcus multilocularis serine protein kinase ATM 0.0025 0.0566 0.0587
Brugia malayi RNA, U transporter 1 0.008 0.2374 0.3561
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.034 0.0446
Echinococcus multilocularis geminin 0.0191 0.6041 0.6269
Echinococcus granulosus smad 0.0009 0.0031 0.0032
Echinococcus granulosus ATP dependent DNA helicase Q5 0.001 0.0067 0.007
Loa Loa (eye worm) hypothetical protein 0.0047 0.13 0.1349
Plasmodium vivax SET domain protein, putative 0.003 0.0731 1
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0018 0.034 0.2443
Loa Loa (eye worm) ATP-dependent DNA helicase 0.001 0.0067 0.007
Schistosoma mansoni importin beta-1 0.0028 0.0664 0.0689
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0576 0.6589
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0099 0.3007 0.312
Giardia lamblia GTOR 0.0018 0.034 1
Echinococcus granulosus zinc finger protein 0.002 0.039 0.0405
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0056 0.1582 0.1642
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0018 0.034 0.0265
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0044 0.118 0.1111
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.034 0.0446
Echinococcus granulosus Smad4 0.0009 0.0031 0.0032
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0011 0.011 0.0114
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0038 0.1005 0.5
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0011 0.011 0.0114
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0489 0.0415
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.034 0.0446
Schistosoma mansoni coup transcription factor 0.0011 0.011 0.0114
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.034 0.0446
Brugia malayi Bloom's syndrome protein homolog 0.0024 0.0536 0.0804
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0489 0.0641
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.006 0.1728 0.1793
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.034 0.0446
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.034 0.0446
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0018 0.034 0.0227
Loa Loa (eye worm) latrophilin receptor protein 2 0.0048 0.1315 0.1364
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.011 0.0114
Brugia malayi nuclear receptor NHR-88 0.0011 0.011 0.0165
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0018 0.034 0.0353
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0011 0.011 0.0114
Trichomonas vaginalis PIKK family atypical protein kinase 0.0011 0.0116 0.0152
Echinococcus multilocularis GPCR, family 2 0.0048 0.1315 0.1364
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.001 0.0067 0.007
Schistosoma mansoni hypothetical protein 0.03 0.9637 1
Loa Loa (eye worm) RecQ helicase 0.0024 0.0536 0.0557
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0013 0.0164 0.0049
Loa Loa (eye worm) hypothetical protein 0.0041 0.1096 0.1137
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0047 0.13 0.1349
Echinococcus granulosus geminin 0.0191 0.6041 0.6269
Schistosoma mansoni smad1 5 8 and 0.0009 0.0031 0.0032
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.001 0.0067 0.007
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0018 0.034 0.0227
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0011 0.011 0.0114
Loa Loa (eye worm) hypothetical protein 0.0011 0.011 0.0114
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0048 0.1315 0.1972
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0047 0.13 0.1349
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.034 0.0446
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0099 0.3007 0.312
Loa Loa (eye worm) hypothetical protein 0.0039 0.1017 0.1055
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0011 0.011 0.0114
Brugia malayi photoreceptor-specific nuclear receptor 0.0011 0.011 0.0165
Trichomonas vaginalis PIKK family atypical protein kinase 0.001 0.0077 0.0101
Loa Loa (eye worm) hypothetical protein 0.0103 0.3146 0.3265
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0047 0.13 0.1349
Loa Loa (eye worm) hypothetical protein 0.0011 0.0116 0.012
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0147 0.4594 0.4504
Echinococcus granulosus methyl CpG binding domain protein 2 0.0017 0.0306 0.0317
Loa Loa (eye worm) inositol-1 0.0043 0.1154 0.1197
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0011 0.011 0.0114
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0011 0.011 0.0165
Schistosoma mansoni hypothetical protein 0.0191 0.6041 0.6269
Trichomonas vaginalis PIKK family atypical protein kinase 0.001 0.0077 0.0101
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.034 0.0446
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.011 0.0165
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0018 0.034 0.0179
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0011 0.011 0.0114
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0099 0.3007 0.312
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0011 0.011 0.0114
Schistosoma mansoni bromodomain containing protein 0.0064 0.1848 0.1917
Entamoeba histolytica hypothetical protein 0.0023 0.0489 0.3826
Leishmania major phosphatidylinositol 3-kinase, putative 0.0018 0.034 0.0179
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0011 0.0113 0.0118
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.034 0.0446
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.034 0.0446
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0009 0.0031 0.0032
Onchocerca volvulus 0.003 0.0731 0.0826
Schistosoma mansoni smad 0.0009 0.0031 0.0032
Schistosoma mansoni inositol monophosphatase 0.0043 0.1154 0.1197
Schistosoma mansoni hypothetical protein 0.0021 0.0425 0.0441
Loa Loa (eye worm) hypothetical protein 0.001 0.0067 0.007
Brugia malayi PHD-finger family protein 0.0025 0.0568 0.0852
Loa Loa (eye worm) hypothetical protein 0.0011 0.011 0.0114
Brugia malayi steroid hormone receptor 0.0011 0.011 0.0165
Loa Loa (eye worm) hypothetical protein 0.0011 0.011 0.0114
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.011 0.0165
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.034 0.0446
Trichomonas vaginalis PIKK family atypical protein kinase 0.001 0.0077 0.0101
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0016 0.0271 0.154
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0011 0.011 0.0114
Loa Loa (eye worm) phosphatidylinositol 3 0.0018 0.034 0.0353
Mycobacterium ulcerans hypothetical protein 0.0164 0.5143 1
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0011 0.011 0.0165
Schistosoma mansoni smad1 5 8 and 0.0009 0.0031 0.0032
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0018 0.034 0.2443
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0021 0.0439 0.6233
Schistosoma mansoni Smad4 0.0009 0.0031 0.0032
Trichomonas vaginalis DNA helicase recq, putative 0.0013 0.0164 0.0215
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0011 0.011 0.0114
Loa Loa (eye worm) hypothetical protein 0.0011 0.011 0.0114
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0576 0.0466
Brugia malayi Importin beta-1 subunit 0.0028 0.0664 0.0996
Trichomonas vaginalis PIKK family atypical protein kinase 0.001 0.0077 0.0101
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0018 0.034 0.0265
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0489 0.0641
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0011 0.011 0.0114
Schistosoma mansoni hypothetical protein 0.0048 0.1315 0.1364
Loa Loa (eye worm) hypothetical protein 0.0011 0.011 0.0114
Loa Loa (eye worm) PHD-finger family protein 0.0021 0.0425 0.0441
Entamoeba histolytica hypothetical protein 0.0025 0.0566 0.4537
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0576 0.8527
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0664 0.0555
Schistosoma mansoni hypothetical protein 0.0011 0.0113 0.0118
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.011 0.0114
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0018 0.0341 0.0266
Toxoplasma gondii hypothetical protein 0.005 0.1392 1
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0311 1 1
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0011 0.011 0.0114
Brugia malayi hypothetical protein 0.0025 0.0576 0.0864
Echinococcus granulosus inositol monophosphatase 1 0.0043 0.1154 0.1197
Loa Loa (eye worm) hypothetical protein 0.0022 0.0449 0.0466
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0147 0.4594 0.4552
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.034 0.0446
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.011 0.0114
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0018 0.034 0.051
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0056 0.1582 0.1074
Loa Loa (eye worm) hypothetical protein 0.0071 0.2096 0.2175
Brugia malayi Inositol-1 0.0043 0.1154 0.173
Echinococcus multilocularis snurportin 1 0.03 0.9637 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.001 0.0077 0.0101
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0099 0.3007 0.312
Echinococcus multilocularis ecdysone induced protein 78C 0.0011 0.011 0.0114
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.034 0.0446
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0018 0.034 0.0353
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0018 0.034 0.0353
Brugia malayi MH1 domain containing protein 0.0009 0.0031 0.0047
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0018 0.034 0.0265
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0053 0.1496 0.143
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0011 0.011 0.0114
Echinococcus granulosus importin subunit beta 1 0.0028 0.0664 0.0689
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.001 0.0067 0.000000001134
Brugia malayi Bromodomain containing protein 0.0076 0.2238 0.3357
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0044 0.118 0.1111
Echinococcus multilocularis smad 0.0009 0.0031 0.0032
Loa Loa (eye worm) hypothetical protein 0.0011 0.011 0.0114
Toxoplasma gondii target of rapamycin (TOR), putative 0.0018 0.034 0.2061
Brugia malayi MH2 domain containing protein 0.0009 0.0031 0.0047
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.034 0.0446
Trypanosoma cruzi target of rapamycin kinase 3 0.0018 0.034 0.0265
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0052 0.1458 0.1513
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0664 0.0555
Loa Loa (eye worm) hypothetical protein 0.0025 0.0576 0.0598
Echinococcus multilocularis thyroid hormone receptor alpha 0.0011 0.011 0.0114
Brugia malayi Pre-SET motif family protein 0.003 0.0731 0.1096
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0056 0.1582 0.1642
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0011 0.011 0.0114
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0576 0.3844
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0011 0.011 0.0114
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0018 0.034 0.0179
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0013 0.0164 0.0088
Brugia malayi Bromodomain containing protein 0.0039 0.1014 0.1521
Schistosoma mansoni zinc finger protein 0.0015 0.0247 0.0257
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0017 0.0306 0.0317
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.001 0.0067 0.01
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.001 0.0067 0.01
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0018 0.034 0.0179
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0043 0.1154 0.1085
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0099 0.3007 0.312
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.001 0.0077 0.0116
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0043 0.1154 0.1085
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0011 0.011 0.0165
Loa Loa (eye worm) hypothetical protein 0.0122 0.3761 0.3903
Echinococcus granulosus serine:threonine protein kinase SMG1 0.001 0.0077 0.008
Brugia malayi Calcitonin receptor-like protein seb-1 0.0151 0.4724 0.7085
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0731 0.5011
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.034 0.0446
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.034 0.0446
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0099 0.3007 0.451
Echinococcus granulosus bloom syndrome protein 0.0024 0.0536 0.0557
Plasmodium vivax importin-beta 2, putative 0.0028 0.0664 0.8529
Echinococcus granulosus serine protein kinase ATM 0.0025 0.0566 0.0587
Echinococcus granulosus mothers against decapentaplegic 5 0.0009 0.0031 0.0032
Schistosoma mansoni thyroid hormone receptor 0.0011 0.011 0.0114
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.034 0.0446
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.034 0.0446
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0018 0.034 0.0353
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0023 0.0489 0.0507
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0018 0.034 0.0227
Schistosoma mansoni retinoic acid receptor RXR 0.0011 0.011 0.0114
Loa Loa (eye worm) steroid hormone receptor 0.0011 0.011 0.0114
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.011 0.0165
Loa Loa (eye worm) MH1 domain-containing protein 0.0009 0.0031 0.0032
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0018 0.034 0.0179
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0011 0.011 0.0165
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.034 0.0446
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0043 0.1154 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.011 0.0165
Loa Loa (eye worm) MH2 domain-containing protein 0.0009 0.0031 0.0032
Loa Loa (eye worm) hypothetical protein 0.001 0.0077 0.008
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.034 0.0446
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0011 0.011 0.0114
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0056 0.1582 0.1642
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0011 0.011 0.0114
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0043 0.1154 0.5
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0011 0.0116 0.037
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.034 0.0446
Echinococcus granulosus snurportin 1 0.03 0.9637 1
Loa Loa (eye worm) hypothetical protein 0.0151 0.4724 0.4902
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0011 0.011 0.0114
Brugia malayi latrophilin 2 splice variant baaae 0.0103 0.3146 0.4718
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0048 0.1315 0.1364
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0306 0.0317
Echinococcus granulosus TGF beta signal transducer SmadC 0.0009 0.0031 0.0032
Schistosoma mansoni hypothetical protein 0.0191 0.6041 0.6269
Schistosoma mansoni RAR-like nuclear receptor 0.0011 0.011 0.0114
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0011 0.011 0.0114
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0011 0.011 0.0165
Loa Loa (eye worm) bromodomain containing protein 0.0018 0.0326 0.0338
Echinococcus granulosus ATP dependent DNA helicase Q1 0.001 0.0067 0.007
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0566 0.0742
Schistosoma mansoni smad1 5 8 and 0.0009 0.0031 0.0032
Schistosoma mansoni hypothetical protein 0.0048 0.1315 0.1364
Schistosoma mansoni thyroid hormone receptor 0.0011 0.011 0.0114
Schistosoma mansoni nuclear hormone receptor 0.0011 0.011 0.0114
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0018 0.034 0.0227
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0044 0.118 0.1077
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0099 0.3007 0.312
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0731 0.0759
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0056 0.1582 0.2373
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0043 0.1154 0.1513
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0576 0.0503
Leishmania major hypothetical protein, conserved 0.0015 0.0247 0.0085
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.034 0.0446
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0048 0.1315 0.1364
Brugia malayi Smad1 0.0009 0.0031 0.0047
Onchocerca volvulus 0.0239 0.7625 1
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0022 0.0449 0.0375
Loa Loa (eye worm) Smad1 0.0009 0.0031 0.0032
Toxoplasma gondii HEAT repeat-containing protein 0.0028 0.0664 0.4508
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0731 0.0759
Brugia malayi Latrophilin receptor protein 2 0.0048 0.1315 0.1972
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0048 0.1315 0.1364
Brugia malayi Pre-SET motif family protein 0.021 0.6668 1
Loa Loa (eye worm) hypothetical protein 0.0028 0.0664 0.0689
Echinococcus multilocularis importin subunit beta 1 0.0028 0.0664 0.0689
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0043 0.1154 0.1513
Echinococcus granulosus histone lysine methyltransferase setb 0.0047 0.13 0.1349
Echinococcus multilocularis zinc finger protein 0.002 0.039 0.0405
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.034 0.0446
Trichomonas vaginalis set domain proteins, putative 0.0239 0.7625 1
Schistosoma mansoni fkbp-rapamycin associated protein 0.001 0.0077 0.008
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0025 0.0566 0.0587
Entamoeba histolytica recQ family helicase, putative 0.0013 0.0164 0.0807
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0576 0.0503
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0036 0.0935 0.0971
Brugia malayi Steroid receptor seven-up type 2 0.0011 0.011 0.0165
Loa Loa (eye worm) phosphatidylinositol 3 0.0018 0.034 0.0353
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0147 0.4594 0.4531
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0025 0.0566 0.0848
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0048 0.1315 0.1364
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0116 0.0152
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0056 0.1582 0.1074
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.011 0.0165
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0011 0.0113 0.0118
Trypanosoma cruzi ISWI complex protein 0.0015 0.0247 0.0171
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0025 0.0566 0.0455
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0695 0.0721
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0018 0.034 0.0265
Schistosoma mansoni hypothetical protein 0.0048 0.1315 0.1364
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0025 0.0566 0.0492
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0011 0.011 0.0114
Echinococcus granulosus ecdysone induced protein 78C 0.0011 0.011 0.0114
Schistosoma mansoni blooms syndrome DNA helicase 0.0019 0.0368 0.0382
Brugia malayi ecdysteroid receptor 0.0011 0.011 0.0165
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.034 0.0446
Echinococcus granulosus FTZ F1 alpha 0.0011 0.011 0.0114
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0043 0.1154 0.105
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0036 0.0935 0.0971
Plasmodium falciparum importin beta, putative 0.0028 0.0664 1
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.03 0.9637 1
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0011 0.011 0.0114
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0011 0.011 0.0165
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0151 0.4724 0.4902
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0043 0.1154 0.8199
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.001 0.0077 0.008
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0011 0.011 0.0114
Loa Loa (eye worm) hypothetical protein 0.0043 0.1159 0.1203
Loa Loa (eye worm) MH2 domain-containing protein 0.0131 0.4054 0.4207
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.011 0.0114
Brugia malayi MH2 domain containing protein 0.0131 0.4054 0.6081
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0731 0.0759
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.034 0.0446
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.006 0.1728 0.1793
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0044 0.118 0.1111
Mycobacterium tuberculosis Conserved hypothetical protein 0.0164 0.5143 1
Echinococcus multilocularis bloom syndrome protein 0.0024 0.0536 0.0557
Leishmania major hypothetical protein, conserved 0.0025 0.0576 0.0419
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0018 0.034 0.0227
Brugia malayi nuclear hormone receptor 0.0011 0.011 0.0165
Trichomonas vaginalis DNA helicase recq, putative 0.0024 0.0536 0.0703
Trichomonas vaginalis PIKK family atypical protein kinase 0.001 0.0077 0.0101
Trypanosoma brucei ISWI complex protein 0.0015 0.0247 0.0133
Schistosoma mansoni steroid hormone receptor ad4bp 0.0011 0.011 0.0114
Brugia malayi hypothetical protein 0.0016 0.0279 0.0418
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.011 0.0165

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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