Detailed information for compound 1168339

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 437.329 | Formula: C23H21BrN2O2
  • H donors: 0 H acceptors: 1 LogP: 3.49 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: Brc1ccc(cc1)COc1ccc(cc1)C(=O)C1CN=c2n(C1)ccc(c2)C
  • InChi: 1S/C23H21BrN2O2/c1-16-10-11-26-14-19(13-25-22(26)12-16)23(27)18-4-8-21(9-5-18)28-15-17-2-6-20(24)7-3-17/h2-12,19H,13-15H2,1H3
  • InChiKey: SPWVURCRHXSCLI-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni hypothetical protein 0.0011 0.0013 0.0022
Echinococcus multilocularis PWWP domain containing protein 2A 0.0011 0.0013 0.0013
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0151 0.1543 0.2571
Schistosoma mansoni thyroid hormone receptor 0.0011 0.0014 0.0024
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0017 0.0082 0.0136
Echinococcus multilocularis cpg binding protein 0.0035 0.0278 0.0278
Loa Loa (eye worm) histone methyltransferase 0.0012 0.0027 0.0038
Schistosoma mansoni hypothetical protein 0.0052 0.0463 0.0771
Trichomonas vaginalis chromobox protein, putative 0.0013 0.0036 0.0127
Loa Loa (eye worm) hypothetical protein 0.0081 0.0776 0.2064
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0045 0.0381 0.129
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0036 0.0127
Schistosoma mansoni hypothetical protein 0.0013 0.0036 0.0061
Loa Loa (eye worm) hypothetical protein 0.0334 0.3528 0.951
Onchocerca volvulus 0.0049 0.043 0.146
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0011 0.0014 0.0014
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0014 0.0003
Brugia malayi nuclear hormone receptor 0.0011 0.0014 0.0003
Echinococcus granulosus mixed lineage leukemia protein mll 0.001 0.0006 0.0011
Echinococcus multilocularis geminin 0.0561 0.6003 0.6003
Loa Loa (eye worm) PHD-finger family protein 0.0024 0.0151 0.0375
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0114 0.0396
Entamoeba histolytica hypothetical protein 0.0013 0.0036 0.1329
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0011 0.0014 0.0024
Echinococcus granulosus dnaJ subfamily B 0.0446 0.4746 0.7905
Echinococcus multilocularis histone lysine N methyltransferase, H3 lysine 36 0.0014 0.0048 0.0048
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0036 0.0127
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0011 0.0014 0.0024
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0013 0.0036 0.1329
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0013 0.0036 0.1329
Leishmania major hypothetical protein, conserved 0.0018 0.0085 0.0596
Entamoeba histolytica hypothetical protein 0.0013 0.0036 0.1329
Schistosoma mansoni hypothetical protein 0.003 0.0217 0.0361
Schistosoma mansoni cpg binding protein 0.0035 0.0278 0.0463
Onchocerca volvulus 0.0013 0.0036 0.0082
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0013 0.0036 0.0403
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0011 0.0014 0.0024
Trypanosoma brucei variant surface glycoprotein (VSG), putative 0.0122 0.1222 1
Loa Loa (eye worm) hypothetical protein 0.0013 0.0036 0.0064
Brugia malayi Pre-SET motif family protein 0.024 0.2509 0.6754
Brugia malayi F/Y-rich N-terminus family protein 0.0014 0.005 0.0099
Brugia malayi mbt repeat family protein 0.0055 0.0489 0.1288
Echinococcus granulosus chromobox protein 1 0.008 0.0763 0.127
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0013 0.0036 0.0127
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0.0103 0.543
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0014 0.0024
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0165 0.1692 0.4542
Loa Loa (eye worm) hypothetical protein 0.0031 0.023 0.0588
Loa Loa (eye worm) hypothetical protein 0.0044 0.0373 0.0973
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0027 0.019 1
Entamoeba histolytica acyl-CoA synthetase, putative 0.0027 0.019 1
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0215 0.2237 0.2237
Loa Loa (eye worm) hypothetical protein 0.0055 0.0489 0.1288
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0082 0.0082
Onchocerca volvulus 0.0055 0.0489 0.1667
Echinococcus multilocularis chromobox protein 1 0.008 0.0763 0.0763
Treponema pallidum bacterioferrin (TpF1) 0.001 0 0.5
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0082 0.0082
Brugia malayi Calcitonin receptor-like protein seb-1 0.0165 0.1692 0.4542
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0082 0.0082
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0151 0.1543 0.2571
Toxoplasma gondii isocitrate dehydrogenase 0.0017 0.0082 0.1179
Loa Loa (eye worm) hypothetical protein 0.002 0.0115 0.0276
Echinococcus granulosus tar DNA binding protein 0.0073 0.0684 0.1139
Schistosoma mansoni steroid hormone receptor ad4bp 0.0011 0.0014 0.0024
Echinococcus multilocularis mixed lineage leukemia protein mll 0.001 0.0006 0.0006
Brugia malayi Bromodomain containing protein 0.0044 0.0372 0.0971
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0036 0.0287 0.4704
Echinococcus granulosus chromobox protein 1 0.008 0.0763 0.127
Schistosoma mansoni mixed-lineage leukemia protein mll 0.001 0.0006 0.0011
Schistosoma mansoni tar DNA-binding protein 0.0073 0.0684 0.1139
Schistosoma mansoni hypothetical protein 0.0332 0.3508 0.5843
Schistosoma mansoni cpg binding protein 0.0035 0.0278 0.0463
Leishmania major 4-coumarate:coa ligase-like protein 0.0027 0.019 0.1463
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0.0103 0.543
Echinococcus granulosus histone lysine N methyltransferase NSD3 0.0039 0.0324 0.0539
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0017 0.0082 0.5757
Loa Loa (eye worm) hypothetical protein 0.002 0.0115 0.0276
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0017 0.0082 0.0136
Schistosoma mansoni chromobox protein 0.0013 0.0036 0.0061
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0014 0.0014
Echinococcus multilocularis chromobox protein 1 0.008 0.0763 0.0763
Brugia malayi AMP-binding enzyme family protein 0.0027 0.019 0.0479
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0027 0.019 1
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0011 0.0014 0.0024
Echinococcus granulosus lamin 0.0031 0.023 0.0384
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0011 0.0014 0.0024
Mycobacterium ulcerans acyl-CoA synthetase 0.0027 0.019 1
Loa Loa (eye worm) hypothetical protein 0.0062 0.0571 0.151
Loa Loa (eye worm) hypothetical protein 0.0011 0.0014 0.0003
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0036 0.0287 0.0287
Brugia malayi latrophilin 2 splice variant baaae 0.0113 0.1123 0.3003
Echinococcus multilocularis thyroid hormone receptor alpha 0.0011 0.0014 0.0014
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0122 0.1222 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0276 0.0712
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0017 0.0082 0.0569
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0151 0.1543 0.2571
Schistosoma mansoni SET domain protein 0.0039 0.0324 0.0539
Brugia malayi Associated with TFs and helicases family protein 0.0013 0.0036 0.0064
Loa Loa (eye worm) isocitrate dehydrogenase 0.0017 0.0082 0.0186
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0122 0.1222 1
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0011 0.0014 0.0003
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0011 0.0014 0.0003
Schistosoma mansoni phd finger protein 0.0014 0.0042 0.0071
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0015 0.0057 0.0094
Loa Loa (eye worm) bromodomain containing protein 0.002 0.0115 0.0275
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.007 0.0658 0.0658
Trypanosoma brucei calpain-like protein, putative 0.0122 0.1222 1
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.007 0.0658 0.1096
Echinococcus multilocularis chromodomain helicase DNA binding protein 1 0.0013 0.0036 0.0036
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0011 0.0014 0.0003
Echinococcus multilocularis FTZ F1 alpha 0.0011 0.0014 0.0014
Echinococcus multilocularis Chromo domain 0.0013 0.0036 0.0036
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0011 0.0014 0.0003
Entamoeba histolytica acyl-coA synthetase, putative 0.0027 0.019 1
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0052 0.0463 0.0463
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0122 0.1222 1
Brugia malayi Type III restriction enzyme, res subunit family protein 0.0013 0.0036 0.0064
Loa Loa (eye worm) hypothetical protein 0.0013 0.0036 0.0064
Schistosoma mansoni hypothetical protein 0.0018 0.0085 0.0142
Schistosoma mansoni hypothetical protein 0.0052 0.0463 0.0771
Echinococcus multilocularis lamin dm0 0.0031 0.023 0.023
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.0014 0.0003
Brugia malayi Pre-SET motif family protein 0.0036 0.0287 0.0743
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0069 0.0644 0.1073
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0114 0.0396
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0017 0.0082 0.0082
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0052 0.0463 0.0771
Loa Loa (eye worm) hypothetical protein 0.0011 0.0014 0.0003
Trichomonas vaginalis chromobox protein, putative 0.0013 0.0036 0.0127
Loa Loa (eye worm) hypothetical protein 0.0334 0.3528 0.951
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0122 0.1222 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0151 0.1543 0.1543
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0017 0.0082 0.0569
Schistosoma mansoni tar DNA-binding protein 0.0073 0.0684 0.1139
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0073 0.0684 0.1815
Loa Loa (eye worm) helicase 0.0013 0.0036 0.0064
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0114 0.0396
Echinococcus multilocularis GPCR, family 2 0.0052 0.0463 0.0463
Echinococcus multilocularis Chromobox protein 3 0.0013 0.0036 0.0036
Echinococcus multilocularis tar DNA binding protein 0.0073 0.0684 0.0684
Schistosoma mansoni sex comb on midleg homolog 0.0055 0.0489 0.0814
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0122 0.1222 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0165 0.1692 0.4542
Loa Loa (eye worm) hypothetical protein 0.0051 0.0445 0.117
Schistosoma mansoni tar DNA-binding protein 0.0073 0.0684 0.1139
Echinococcus multilocularis chromobox protein 2 0.0013 0.0036 0.0036
Loa Loa (eye worm) hypothetical protein 0.0011 0.0014 0.0003
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0049 0.043 0.0716
Echinococcus granulosus GPCR family 2 0.0052 0.0463 0.0771
Toxoplasma gondii chromodomain helicase DNA binding protein CHD1/SWI2/SNF2 0.0013 0.0036 0.0403
Brugia malayi Isocitrate dehydrogenase 0.0017 0.0082 0.0186
Schistosoma mansoni nuclear hormone receptor 0.0011 0.0014 0.0024
Loa Loa (eye worm) intermediate filament protein 0.0031 0.023 0.0588
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0011 0.0014 0.0003
Loa Loa (eye worm) TAR-binding protein 0.0073 0.0684 0.1815
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0.0103 0.543
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0011 0.0014 0.0024
Loa Loa (eye worm) hypothetical protein 0.0013 0.0036 0.0064
Echinococcus granulosus protein quaking 0.003 0.0217 0.0361
Schistosoma mansoni chromobox protein 0.0013 0.0036 0.0061
Echinococcus granulosus lamin dm0 0.0031 0.023 0.0384
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.002 0.0115 0.6065
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0017 0.008 0.0133
Brugia malayi nuclear receptor NHR-88 0.0011 0.0014 0.0003
Mycobacterium ulcerans acyl-CoA synthetase 0.0027 0.019 1
Echinococcus granulosus polycomb protein SCMH1 0.0055 0.0489 0.0814
Loa Loa (eye worm) hypothetical protein 0.003 0.0217 0.0553
Echinococcus multilocularis peregrin 0.0014 0.0042 0.0042
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0239 0.0833
Loa Loa (eye worm) hypothetical protein 0.003 0.0224 0.0572
Loa Loa (eye worm) hypothetical protein 0.0014 0.005 0.0101
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.002 0.0114 0.0396
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.0014 0.0003
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.002 0.0114 0.0396
Mycobacterium ulcerans fatty-acid-CoA ligase 0.002 0.0115 0.6065
Schistosoma mansoni hepatoma derived growth factor 0.0011 0.0013 0.0022
Leishmania major 4-coumarate:coa ligase-like protein 0.0027 0.019 0.1463
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0036 0.0127
Echinococcus multilocularis muscleblind protein 0.0334 0.3528 0.3528
Loa Loa (eye worm) hypothetical protein 0.0013 0.0036 0.0064
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0041 0.0342 0.057
Onchocerca volvulus 0.0031 0.023 0.0762
Onchocerca volvulus 0.0031 0.0235 0.0778
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0114 0.0396
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0011 0.0014 0.0003
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0011 0.0014 0.0024
Schistosoma mansoni hepatoma derived growth factor 0.0011 0.0013 0.0022
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0151 0.1543 0.4141
Echinococcus granulosus PWWP domain containing protein 2A 0.0011 0.0013 0.0022
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0013 0.0036 0.0061
Schistosoma mansoni lamin 0.0031 0.023 0.0384
Loa Loa (eye worm) hypothetical protein 0.0011 0.0014 0.0003
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0052 0.0463 0.0771
Brugia malayi cytoplasmic intermediate filament protein 0.0017 0.0074 0.0166
Trypanosoma cruzi ISWI complex protein 0.0018 0.0085 0.0596
Echinococcus multilocularis dnaJ subfamily B 0.0446 0.4746 0.4746
Schistosoma mansoni tar DNA-binding protein 0.0073 0.0684 0.1139
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0013 0.0036 0.0061
Loa Loa (eye worm) hypothetical protein 0.0011 0.0014 0.0003
Echinococcus granulosus fetal alzheimer antigen falz 0.0028 0.0195 0.0324
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0033 0.0253 0.0421
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.0014 0.0003
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0036 0.0127
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0011 0.0014 0.0003
Brugia malayi Latrophilin receptor protein 2 0.0052 0.0463 0.1218
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0056 0.05 0.05
Leishmania major 4-coumarate:coa ligase-like protein 0.0027 0.019 0.1463
Brugia malayi M-phase phosphoprotein, mpp8 0.0013 0.0036 0.0064
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0011 0.0014 0.0003
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0151 0.1543 0.2571
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0014 0.0024
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0031 0.023 0.0588
Schistosoma mansoni intermediate filament proteins 0.0031 0.023 0.0384
Brugia malayi SET domain containing protein 0.0016 0.0071 0.0158
Onchocerca volvulus 0.0035 0.0276 0.0921
Schistosoma mansoni RAR-like nuclear receptor 0.0011 0.0014 0.0024
Schistosoma mansoni coup transcription factor 0.0011 0.0014 0.0024
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0012 0.0027 0.0027
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0011 0.0014 0.0024
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0011 0.0014 0.0014
Brugia malayi Valyl-tRNA synthetase 0.0013 0.0036 0.0064
Schistosoma mansoni lamin 0.0031 0.023 0.0384
Wolbachia endosymbiont of Brugia malayi bacterioferritin/cytochrome b1 0.001 0 0.5
Schistosoma mansoni retinoic acid receptor RXR 0.0011 0.0014 0.0024
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0056 0.05 0.0833
Loa Loa (eye worm) heterochromatin protein 1 0.008 0.0763 0.2028
Loa Loa (eye worm) hypothetical protein 0.0113 0.1123 0.3003
Echinococcus multilocularis histone lysine N methyltransferase NSD3 0.0039 0.0324 0.0324
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0011 0.0014 0.0003
Loa Loa (eye worm) CHromoDomain protein family member 0.0017 0.008 0.0181
Trichomonas vaginalis chromobox protein, putative 0.0048 0.0418 0.1458
Loa Loa (eye worm) hypothetical protein 0.0165 0.1692 0.4542
Echinococcus granulosus SAM and MBT domain containing protein 0.0055 0.0489 0.0814
Trypanosoma cruzi ISWI complex protein 0.0018 0.0085 0.0596
Toxoplasma gondii isocitrate dehydrogenase 0.0017 0.0082 0.1179
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0055 0.0489 0.0814
Loa Loa (eye worm) hypothetical protein 0.0013 0.0036 0.0064
Loa Loa (eye worm) hypothetical protein 0.0027 0.019 0.0479
Schistosoma mansoni SET domain protein 0.0018 0.0091 0.0152
Loa Loa (eye worm) hypothetical protein 0.002 0.0115 0.0276
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0381 0.1329
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0011 0.0014 0.0004
Plasmodium vivax SET domain protein, putative 0.0036 0.0287 1
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.002 0.0115 0.5
Onchocerca volvulus Protein ultraspiracle homolog 0.0011 0.0014 0.0004
Trichomonas vaginalis chromobox protein, putative 0.0048 0.0418 0.1458
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0011 0.0014 0.0003
Echinococcus multilocularis ecdysone induced protein 78C 0.0011 0.0014 0.0014
Loa Loa (eye worm) hypothetical protein 0.0052 0.0463 0.1218
Echinococcus granulosus hypothetical protein 0.003 0.0217 0.0361
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0028 0.0195 0.0324
Brugia malayi RNA recognition motif domain containing protein 0.0073 0.0684 0.1815
Echinococcus granulosus geminin 0.0561 0.6003 1
Onchocerca volvulus 0.0027 0.019 0.062
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0239 0.0833
Schistosoma mansoni thyroid hormone receptor 0.0011 0.0014 0.0024
Trypanosoma brucei calpain, putative 0.0122 0.1222 1
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0027 0.019 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.0014 0.0003
Echinococcus multilocularis PWWP domain containing protein 2A 0.0011 0.0013 0.0013
Trypanosoma brucei hypothetical protein 0.0122 0.1222 1
Echinococcus multilocularis isocitrate dehydrogenase 0.0017 0.0082 0.0082
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0006 0.0011
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0017 0.0078 0.0272
Echinococcus multilocularis histone acetyltransferase MYST2 0.0062 0.0571 0.0571
Echinococcus granulosus zinc finger protein 0.0024 0.0158 0.0263
Echinococcus granulosus Chromobox protein 3 0.0013 0.0036 0.0061
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0122 0.1222 1
Loa Loa (eye worm) tumor suppressor 0.035 0.3709 1
Brugia malayi Protein cec-1. 0.0013 0.0036 0.0064
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0151 0.1543 0.2571
Brugia malayi chromobox protein homolog 3 0.0045 0.0381 0.0996
Echinococcus granulosus peregrin 0.0014 0.0042 0.0071
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0013 0.0036 0.1329
Brugia malayi AMP-binding enzyme family protein 0.0027 0.019 0.0479
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0048 0.0418 0.1419
Loa Loa (eye worm) mbt repeat family protein 0.0055 0.0489 0.1288
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0078 0.0272
Entamoeba histolytica acyl-CoA synthetase, putative 0.0027 0.019 1
Brugia malayi hypothetical protein 0.0013 0.0036 0.0064
Loa Loa (eye worm) hypothetical protein 0.0027 0.019 0.0479
Schistosoma mansoni methyl-cpg binding protein mbd 0.002 0.0107 0.0178
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0082 0.0569
Loa Loa (eye worm) RNA binding protein 0.0073 0.0684 0.1815
Schistosoma mansoni methyl-cpg binding protein mbd 0.002 0.0107 0.0178
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0122 0.1222 1
Schistosoma mansoni bromodomain containing protein 0.0074 0.0702 0.117
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0041 0.0342 0.0342
Mycobacterium ulcerans acyl-CoA synthetase 0.0027 0.019 1
Brugia malayi Temporarily assigned gene name protein 44 0.003 0.0217 0.0553
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0.0103 0.543
Schistosoma mansoni hypothetical protein 0.0011 0.0013 0.0022
Schistosoma mansoni chromobox protein 0.008 0.0763 0.127
Brugia malayi intermediate filament protein 0.0031 0.023 0.0588
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0215 0.2237 0.3726
Brugia malayi ecdysteroid receptor 0.0011 0.0014 0.0003
Echinococcus granulosus cpg binding protein 0.0035 0.0278 0.0463
Echinococcus granulosus histone acetyltransferase MYST2 0.0062 0.0571 0.0951
Onchocerca volvulus 0.0013 0.0036 0.0082
Plasmodium vivax acyl-CoA synthetase, putative 0.002 0.0115 0.3133
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0027 0.019 1
Echinococcus granulosus methyl CpG binding domain protein 2 0.002 0.0107 0.0178
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0036 0.0127
Schistosoma mansoni cpg binding protein 0.0031 0.0235 0.0391
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0012 0.0027 0.0045
Loa Loa (eye worm) hypothetical protein 0.002 0.0115 0.0276
Echinococcus granulosus intermediate filament protein 0.0031 0.023 0.0384
Plasmodium falciparum acyl-CoA synthetase 0.002 0.0115 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0011 0.0014 0.0003
Brugia malayi CXXC zinc finger family protein 0.0031 0.0235 0.0601
Schistosoma mansoni hypothetical protein 0.0052 0.0463 0.0771
Echinococcus granulosus chromodomain helicase DNA binding protein 1 0.0013 0.0036 0.0061
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0016 0.0072 0.0252
Schistosoma mansoni hypothetical protein 0.003 0.0217 0.0361
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0027 0.019 1
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0122 0.1222 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.005 0.0101
Loa Loa (eye worm) hypothetical protein 0.002 0.0115 0.0276
Brugia malayi PHD-finger family protein 0.003 0.0224 0.0572
Loa Loa (eye worm) latrophilin receptor protein 2 0.0052 0.0463 0.1218
Brugia malayi hypothetical protein 0.003 0.0217 0.0553
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0013 0.0036 0.0127
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0011 0.0014 0.0003
Onchocerca volvulus 0.0011 0.0014 0.0004
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0014 0.0014
Onchocerca volvulus Bile acid receptor homolog 0.0011 0.0014 0.0004
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0381 0.1329
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0122 0.1222 1
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0055 0.0489 0.1667
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.024 0.2509 0.6754
Toxoplasma gondii histone lysine methyltransferase SET1 0.0065 0.0597 1
Trichomonas vaginalis set domain proteins, putative 0.0273 0.2867 1
Brugia malayi tumor suppressor. 0.035 0.3709 1
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0062 0.0571 0.151
Echinococcus multilocularis musashi 0.0031 0.023 0.023
Echinococcus granulosus histone lysine methyltransferase setb 0.0056 0.05 0.0833
Loa Loa (eye worm) hypothetical protein 0.0027 0.019 0.0479
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0006 0.0006
Brugia malayi Intermediate filament tail domain containing protein 0.0031 0.023 0.0588
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0011 0.0014 0.0024
Echinococcus granulosus PWWP domain containing protein 2A 0.0011 0.0013 0.0022
Brugia malayi RNA binding protein 0.0073 0.0684 0.1815
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0036 0.0127
Schistosoma mansoni hypothetical protein 0.0446 0.4746 0.7905
Loa Loa (eye worm) hypothetical protein 0.0013 0.0036 0.0064
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0011 0.0014 0.0003
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0062 0.0571 0.0571
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0114 0.0396
Loa Loa (eye worm) steroid hormone receptor 0.0011 0.0014 0.0003
Echinococcus granulosus histone lysine N methyltransferase H3 lysine 36 0.0014 0.0048 0.008
Brugia malayi Steroid receptor seven-up type 2 0.0011 0.0014 0.0003
Echinococcus multilocularis methyl CpG binding domain protein 2 0.002 0.0107 0.0107
Echinococcus granulosus muscleblind protein 0.0334 0.3528 0.5876
Echinococcus multilocularis lamin 0.0031 0.023 0.023
Schistosoma mansoni hypothetical protein 0.0024 0.0151 0.0252
Echinococcus granulosus chromobox protein 2 0.0013 0.0036 0.0061
Loa Loa (eye worm) CXXC zinc finger family protein 0.0031 0.0235 0.0601
Brugia malayi isocitrate dehydrogenase 0.0017 0.0082 0.0186
Trypanosoma brucei ISWI complex protein 0.0018 0.0085 0.0596
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0015 0.0057 0.0057
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0017 0.0082 0.1804
Schistosoma mansoni tar DNA-binding protein 0.0073 0.0684 0.1139
Echinococcus multilocularis protein quaking 0.003 0.0217 0.0217
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0011 0.0014 0.0003
Mycobacterium ulcerans hypothetical protein 0.0027 0.019 1
Brugia malayi TAR-binding protein 0.0073 0.0684 0.1815
Schistosoma mansoni hypothetical protein 0.0561 0.6003 1
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0122 0.1222 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.0014 0.0003
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0052 0.0463 0.0463
Loa Loa (eye worm) hypothetical protein 0.0047 0.0402 0.1053
Echinococcus multilocularis SAM and MBT domain containing protein 0.0055 0.0489 0.0489
Brugia malayi photoreceptor-specific nuclear receptor 0.0011 0.0014 0.0003
Schistosoma mansoni chromobox protein 0.008 0.0763 0.127
Loa Loa (eye worm) hypothetical protein 0.0015 0.0057 0.0118
Onchocerca volvulus 0.0031 0.023 0.0762
Trichomonas vaginalis chromobox protein, putative 0.0013 0.0036 0.0127
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0011 0.0014 0.0014
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0036 0.0127
Onchocerca volvulus 0.0273 0.2867 1
Brugia malayi mbt repeat family protein 0.0055 0.0489 0.1288
Schistosoma mansoni hypothetical protein 0.0052 0.0463 0.0771
Brugia malayi Bromodomain containing protein 0.0088 0.0848 0.2261
Schistosoma mansoni hypothetical protein 0.0113 0.1123 0.187
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0028 0.0195 0.0195
Echinococcus multilocularis hepatoma derived growth factor protein 0.0011 0.0013 0.0013
Brugia malayi CHD4 protein 0.0017 0.008 0.0181
Loa Loa (eye worm) hypothetical protein 0.0045 0.0381 0.0996
Loa Loa (eye worm) hypothetical protein 0.0013 0.0036 0.0064
Brugia malayi Muscleblind-like protein 0.0334 0.3528 0.951
Schistosoma mansoni zinc finger protein 0.0018 0.0085 0.0142
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0122 0.1222 1
Schistosoma mansoni sex comb on midleg homolog 0.0055 0.0489 0.0814
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0122 0.1222 1
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0011 0.0014 0.0024
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0017 0.008 0.0133
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0122 0.1222 1
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0017 0.0074 0.0166
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0036 0.0127
Echinococcus granulosus ecdysone induced protein 78C 0.0011 0.0014 0.0024
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0114 0.0396
Schistosoma mansoni hypothetical protein 0.0561 0.6003 1
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0027 0.019 1
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0036 0.0127
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0151 0.1543 0.1543
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0017 0.0082 0.4306
Trichomonas vaginalis Heterochromatin protein, putative 0.0013 0.0036 0.0127
Echinococcus granulosus FTZ F1 alpha 0.0011 0.0014 0.0024
Brugia malayi Heterochromatin protein 1 0.008 0.0763 0.2028
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0082 0.0569
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0082 0.0569
Loa Loa (eye worm) hypothetical protein 0.0011 0.0014 0.0003
Loa Loa (eye worm) hypothetical protein 0.0056 0.05 0.1318
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0013 0.0036 0.0403
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0027 0.019 1
Echinococcus multilocularis zinc finger protein 0.0024 0.0158 0.0158
Echinococcus granulosus Chromo domain 0.0013 0.0036 0.0061
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0017 0.008 0.008
Schistosoma mansoni myelin transcription factor 1 myt1 0.0062 0.0571 0.0951
Schistosoma mansoni zinc finger protein 0.0024 0.0158 0.0263
Brugia malayi steroid hormone receptor 0.0011 0.0014 0.0003
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0011 0.0014 0.0024
Schistosoma mansoni hypothetical protein 0.0011 0.0013 0.0022
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0056 0.05 0.0833
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0011 0.0014 0.0014
Brugia malayi AMP-binding enzyme family protein 0.0027 0.019 0.0479
Loa Loa (eye worm) hypothetical protein 0.0011 0.0014 0.0003
Echinococcus granulosus hepatoma derived growth factor protein 0.0011 0.0013 0.0022
Trichomonas vaginalis hypothetical protein 0.0013 0.0036 0.0127
Trichomonas vaginalis chromobox protein, putative 0.008 0.0763 0.266
Echinococcus multilocularis polycomb protein SCMH1 0.0055 0.0489 0.0489
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0062 0.0571 0.0951
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0287 0.0479
Loa Loa (eye worm) MBCTL1 0.0062 0.0571 0.151
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0052 0.0463 0.1218
Trichomonas vaginalis chromobox protein, putative 0.008 0.0763 0.266
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0027 0.019 1
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0013 0.0036 0.0061
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0122 0.1222 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.0014 0.0003
Entamoeba histolytica hypothetical protein 0.0013 0.0036 0.1329
Loa Loa (eye worm) hypothetical protein 0.0011 0.0014 0.0003
Echinococcus multilocularis muscleblind protein 1 0.0334 0.3528 0.3528
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0151 0.1543 0.4141

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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