Detailed information for compound 1169019

Basic information

Technical information
  • TDR Targets ID: 1169019
  • Name: 4-(4-imidazol-1-ylphenyl)butanoic acid
  • MW: 230.262 | Formula: C13H14N2O2
  • H donors: 1 H acceptors: 3 LogP: 1.79 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC(=O)CCCc1ccc(cc1)n1cncc1
  • InChi: 1S/C13H14N2O2/c16-13(17)3-1-2-11-4-6-12(7-5-11)15-9-8-14-10-15/h4-10H,1-3H2,(H,16,17)
  • InChiKey: KCLNSRPYEAUPLT-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-[4-(1-imidazolyl)phenyl]butanoic acid
  • 4-(4-imidazol-1-ylphenyl)butyric acid

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis caspase 2 0.0086 0.0048 0.0242
Schistosoma mansoni hypothetical protein 0.0036 0.0012 0.0418
Onchocerca volvulus 0.0088 0.0049 0.2801
Schistosoma mansoni phd/f-box containing protein 0.0041 0.0015 0.0532
Loa Loa (eye worm) hypothetical protein 0.0036 0.0012 0.0061
Echinococcus multilocularis lysine specific demethylase 6a 0.0041 0.0015 0.0068
Schistosoma mansoni hypothetical protein 0.0041 0.0016 0.0554
Onchocerca volvulus 0.0032 0.0009 0.0165
Brugia malayi hypothetical protein 0.0036 0.0012 0.003
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0027 0.0005 0.0017
Brugia malayi jmjC domain containing protein 0.0041 0.0015 0.0047
Schistosoma mansoni lamin 0.0028 0.0006 0.0213
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0213 0.0141 0.073
Schistosoma mansoni hypothetical protein 0.0038 0.0013 0.0465
Schistosoma mansoni jumonji/arid domain-containing protein 0.0159 0.0102 0.3644
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0013 0.0666
Loa Loa (eye worm) hypothetical protein 0.0028 0.0006 0.0029
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.0118 0.0071 0.0364
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0013 0.0666
Brugia malayi Glycosyl hydrolases family 31 protein 0.0038 0.0013 0.0037
Echinococcus multilocularis apoptotic protease activating factor 1 0.0041 0.0016 0.0071
Echinococcus granulosus muscleblind protein 0.2627 0.1899 1
Brugia malayi hypothetical protein 0.0238 0.0159 0.0808
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0012 0.0602
Brugia malayi Pre-SET motif family protein 0.0032 0.0009 0.0013
Echinococcus multilocularis neutral alpha glucosidase AB 0.0038 0.0013 0.0059
Brugia malayi RNA binding protein 0.0062 0.0031 0.013
Brugia malayi CXXC zinc finger family protein 0.0088 0.0049 0.0228
Loa Loa (eye worm) hypothetical protein 0.007 0.0036 0.0189
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0019 0.0089
Schistosoma mansoni cpg binding protein 0.0088 0.0049 0.177
Mycobacterium tuberculosis Conserved protein 0.0036 0.0012 0.0003
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0172 0.0111 0.0582
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0012 0.0051
Echinococcus multilocularis dnaJ subfamily B 0.0402 0.0278 0.1454
Echinococcus granulosus survival motor neuron protein 1 0.0238 0.0159 0.0827
Echinococcus multilocularis caspase 0.0118 0.0071 0.0364
Echinococcus granulosus jumonji domain containing protein 0.0041 0.0015 0.0069
Echinococcus granulosus caspase 2 0.0086 0.0048 0.0242
Loa Loa (eye worm) hypothetical protein 0.0028 0.0006 0.0031
Echinococcus multilocularis JmjC domain containing protein 4 0.0041 0.0015 0.0068
Echinococcus multilocularis lamin 0.0028 0.0006 0.0021
Echinococcus granulosus fetal alzheimer antigen falz 0.0027 0.0005 0.0017
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.0012 0.0051
Echinococcus granulosus caspase 0.0118 0.0071 0.0364
Loa Loa (eye worm) hypothetical protein 0.0038 0.0013 0.0067
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0108 0.0064 0.2302
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0012 0.0025
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0039 0.0014 0.0353
Mycobacterium leprae Probable imidazole glycerol-phosphate dehydratase HisB 0.6779 0.4924 1
Echinococcus multilocularis PHD finger protein rhinoceros 0.0029 0.0007 0.0025
Schistosoma mansoni jumonji/arid domain-containing protein 0.0159 0.0102 0.3644
Trypanosoma cruzi metacaspase, putative 0.0045 0.0018 0.1185
Loa Loa (eye worm) hypothetical protein 0.0041 0.0016 0.0081
Echinococcus multilocularis Alpha N acetylgalactosaminidase 0.0108 0.0064 0.0327
Brugia malayi jmjC domain containing protein 0.0041 0.0015 0.0047
Loa Loa (eye worm) CXXC zinc finger family protein 0.0088 0.0049 0.0259
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0012 0.0596
Loa Loa (eye worm) hypothetical protein 0.2627 0.1899 1
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0032 0.0009 0.0187
Schistosoma mansoni jumonji domain containing protein 0.0041 0.0015 0.0532
Echinococcus multilocularis geminin 0.0351 0.0241 0.1258
Schistosoma mansoni protein phosphatase 2C 0.0041 0.0015 0.0532
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0045 0.0018 0.1081
Echinococcus granulosus peregrin 0.0032 0.0009 0.0034
Mycobacterium tuberculosis Probable lipase LipE 0.0036 0.0012 0.0003
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0045 0.0018 0.0898
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0012 0.0025
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0144 0.009 0.0081
Echinococcus multilocularis lysine specific demethylase 5A 0.0152 0.0097 0.0497
Trypanosoma cruzi metacaspase, putative 0.0045 0.0018 0.1185
Schistosoma mansoni intermediate filament proteins 0.0028 0.0006 0.0213
Leishmania major alpha glucosidase II subunit, putative 0.0038 0.0013 0.0275
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0294 0.02 1
Trichomonas vaginalis alpha-galactosidase/alpha-N-acetylgalactosaminidase, putative 0.0072 0.0038 0.1903
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0064 0.0032 0.0157
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0039 0.0014 0.0061
Echinococcus granulosus lysosomal alpha glucosidase 0.0172 0.0111 0.0572
Loa Loa (eye worm) hypothetical protein 0.0081 0.0044 0.0232
Schistosoma mansoni hypothetical protein 0.0049 0.0021 0.0742
Brugia malayi beta-lactamase family protein 0.0036 0.0012 0.003
Echinococcus granulosus geminin 0.0351 0.0241 0.1258
Brugia malayi Bromodomain containing protein 0.0079 0.0043 0.0194
Loa Loa (eye worm) TAR-binding protein 0.0062 0.0031 0.0161
Brugia malayi Calcitonin receptor-like protein seb-1 0.0056 0.0026 0.0105
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0029 0.0007 0.0236
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0036 0.0012 0.0003
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.0118 0.0071 0.0364
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.0012 0.0061
Loa Loa (eye worm) hypothetical protein 0.0036 0.0012 0.0061
Trypanosoma brucei Metacaspase-4 0.0045 0.0018 0.1185
Trichomonas vaginalis ap endonuclease, putative 0.0039 0.0014 0.0685
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0045 0.0018 0.0898
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0045 0.0018 0.0898
Schistosoma mansoni hypothetical protein 0.0029 0.0007 0.0236
Schistosoma mansoni subfamily C14A unassigned peptidase (C14 family) 0.0045 0.0018 0.0634
Schistosoma mansoni bromodomain containing protein 0.0067 0.0035 0.1234
Brugia malayi jmjC domain containing protein 0.0041 0.0015 0.0047
Echinococcus granulosus Alpha N acetylgalactosaminidase 0.0108 0.0064 0.0327
Schistosoma mansoni jumonji domain containing protein 0.0193 0.0126 0.4534
Loa Loa (eye worm) hypothetical protein 0.0049 0.0021 0.0109
Echinococcus multilocularis Glycoside hydrolase, family 27 0.0108 0.0064 0.0327
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0039 0.0014 0.0004
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0046 0.0019 0.0099
Brugia malayi Cell death protein 3 precursor 0.0086 0.0048 0.0221
Brugia malayi beta-lactamase 0.0036 0.0012 0.003
Loa Loa (eye worm) hypothetical protein 0.0036 0.0012 0.0061
Brugia malayi jmjC domain containing protein 0.0041 0.0015 0.0047
Brugia malayi F/Y-rich N-terminus family protein 0.0039 0.0014 0.0042
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0039 0.0014 0.035
Echinococcus granulosus JmjC domain containing protein 4 0.0041 0.0015 0.0068
Toxoplasma gondii exonuclease III APE 0.0039 0.0014 0.0665
Echinococcus multilocularis caspase 8 0.0045 0.0018 0.0083
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0294 0.02 1
Echinococcus granulosus PHD finger protein rhinoceros 0.0029 0.0007 0.0025
Schistosoma mansoni caspase-3 (C14 family) 0.0118 0.0071 0.2554
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0018 0.0898
Onchocerca volvulus Cell death protein 3 homolog 0.0086 0.0048 0.2715
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0045 0.0018 0.0898
Loa Loa (eye worm) jmjC domain-containing protein 0.0041 0.0015 0.0078
Schistosoma mansoni cpg binding protein 0.0095 0.0054 0.195
Giardia lamblia Fructose-bisphosphate aldolase 0.0294 0.02 1
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.17 0.1224 0.6439
Loa Loa (eye worm) hypothetical protein 0.0086 0.0048 0.0252
Echinococcus granulosus zinc finger protein 0.0024 0.0003 0.0005
Plasmodium vivax ataxin-2 like protein, putative 0.0106 0.0063 1
Plasmodium falciparum metacaspase-like protein 0.0045 0.0018 0.1976
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0045 0.0018 0.1081
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0031 0.1098
Loa Loa (eye worm) hypothetical protein 0.0045 0.0018 0.0093
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.0012 0.0051
Plasmodium vivax metacaspase 1, putative 0.0045 0.0018 0.1976
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0036 0.0012 0.0006
Loa Loa (eye worm) hypothetical protein 0.004 0.0015 0.0076
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0041 0.0015 0.0804
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0211 0.0139 0.0733
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0036 0.0012 0.0003
Loa Loa (eye worm) intermediate filament protein 0.0028 0.0006 0.0031
Echinococcus multilocularis musashi 0.0028 0.0006 0.0021
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0028 0.0006 0.0021
Onchocerca volvulus 0.0049 0.0021 0.0951
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0213 0.0141 0.073
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0294 0.02 1
Brugia malayi Melibiase family protein 0.0072 0.0038 0.0168
Mycobacterium tuberculosis Probable hydrolase 0.0036 0.0012 0.0003
Mycobacterium ulcerans imidazoleglycerol-phosphate dehydratase 1.3745 1 1
Trypanosoma brucei metacaspase MCA2 0.0045 0.0018 0.1185
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0041 0.0015 0.0532
Toxoplasma gondii histone lysine methyltransferase SET1 0.017 0.0109 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0056 0.0026 0.0105
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0045 0.0018 0.0898
Trypanosoma cruzi metacaspase 5, putative 0.0045 0.0018 0.1185
Brugia malayi TAR-binding protein 0.0062 0.0031 0.013
Trypanosoma cruzi PAB1-binding protein , putative 0.0106 0.0063 1
Onchocerca volvulus Alhambra homolog 0.0029 0.0007 0.0041
Echinococcus multilocularis lysosomal alpha glucosidase 0.0172 0.0111 0.0572
Leishmania major hypothetical protein, conserved 0.0041 0.0015 0.0629
Schistosoma mansoni ap endonuclease 0.0039 0.0014 0.0481
Brugia malayi hypothetical protein 0.0069 0.0035 0.0154
Trichomonas vaginalis maltase-glucoamylase, putative 0.0038 0.0013 0.0666
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0294 0.02 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0056 0.0026 0.0136
Loa Loa (eye worm) hypothetical protein 0.0038 0.0013 0.0068
Echinococcus granulosus caspase 3 0.0073 0.0039 0.0193
Echinococcus granulosus apoptotic protease activating factor 1 0.0041 0.0016 0.0071
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0039 0.0014 0.035
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0028 0.0006 0.0021
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0049 0.0021 0.0078
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0048 0.002 0.0095
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0039 0.0014 1
Loa Loa (eye worm) histone methyltransferase 0.0028 0.0006 0.003
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0012 0.0596
Echinococcus multilocularis jumonji domain containing protein 0.0041 0.0015 0.0069
Loa Loa (eye worm) hypothetical protein 0.0056 0.0026 0.0136
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0041 0.0015 0.0629
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0033 0.0009 0.0319
Mycobacterium tuberculosis Conserved protein 0.0036 0.0012 0.0003
Trypanosoma cruzi metacaspase, putative 0.0045 0.0018 0.1185
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0039 0.0014 0.035
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0013 0.0275
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0072 0.0038 0.1358
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0038 0.0013 0.0666
Trypanosoma cruzi metacaspase 5, putative 0.0045 0.0018 0.1185
Echinococcus granulosus cpg binding protein 0.0095 0.0054 0.0276
Trichomonas vaginalis esterase, putative 0.0036 0.0012 0.0596
Schistosoma mansoni phosphatidylserine receptor 0.0041 0.0015 0.0532
Loa Loa (eye worm) hypothetical protein 0.2627 0.1899 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0187 0.0122 0.438
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0038 0.0013 0.0628
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0038 0.0013 0.0666
Trichomonas vaginalis inositol monophosphatase, putative 0.0036 0.0012 0.0602
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0294 0.02 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0049 0.0021 0.0746
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0012 0.0596
Echinococcus multilocularis survival motor neuron protein 1 0.0238 0.0159 0.0827
Echinococcus granulosus lamin 0.0028 0.0006 0.0021
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0018 0.0898
Plasmodium falciparum metacaspase 1 0.0045 0.0018 0.1976
Echinococcus granulosus phd:f box containing protein 0.0041 0.0015 0.0068
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0018 0.0898
Toxoplasma gondii ABC1 family protein 0.0036 0.0012 0.0491
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0045 0.0018 0.0898
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0039 0.0014 0.1216
Trypanosoma brucei glucosidase, putative 0.0038 0.0013 0.0275
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0031 0.1098
Brugia malayi Muscleblind-like protein 0.2627 0.1899 1
Brugia malayi hypothetical protein 0.0106 0.0063 0.0299
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0036 0.0012 0.0003
Loa Loa (eye worm) hypothetical protein 0.0041 0.0015 0.0078
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0012 0.0051
Brugia malayi exodeoxyribonuclease III family protein 0.0039 0.0014 0.0039
Schistosoma mansoni hypothetical protein 0.0351 0.0241 0.8661
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0012 0.0596
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0049 0.0021 0.0099
Trypanosoma brucei metacaspase MCA3 0.0045 0.0018 0.1185
Brugia malayi Bromodomain containing protein 0.0032 0.0009 0.0012
Echinococcus multilocularis zinc finger protein 0.0024 0.0003 0.0005
Onchocerca volvulus 0.0036 0.0012 0.0367
Schistosoma mansoni alpha-glucosidase 0.0148 0.0093 0.3349
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0048 0.002 0.0095
Schistosoma mansoni caspase-7 (C14 family) 0.0118 0.0071 0.2554
Loa Loa (eye worm) hypothetical protein 0.0081 0.0045 0.0234
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0045 0.0018 0.0898
Schistosoma mansoni caspase-7 (C14 family) 0.0086 0.0048 0.1722
Echinococcus granulosus inositol monophosphatase 1 0.0036 0.0012 0.0052
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0046 0.0019 0.0068
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0036 0.0012 0.0503
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0031 0.1098
Trypanosoma brucei metacaspase 5, putative 0.0045 0.0018 0.1185
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0045 0.0018 0.0898
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.0012 0.003
Schistosoma mansoni lamin 0.0028 0.0006 0.0213
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0019 0.0089
Trichomonas vaginalis set domain proteins, putative 0.024 0.0161 0.8037
Loa Loa (eye worm) PHD-finger family protein 0.0029 0.0007 0.0035
Plasmodium falciparum ataxin-2 like protein, putative 0.0106 0.0063 1
Trypanosoma brucei PAB1-binding protein , putative 0.0106 0.0063 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0009 0.0305
Loa Loa (eye worm) RNA binding protein 0.0062 0.0031 0.0161
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0038 0.0013 0.0074
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0012 0.0602
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0231 0.0154 0.0145
Echinococcus granulosus dnaJ subfamily B 0.0402 0.0278 0.1454
Brugia malayi jmjC domain containing protein 0.0159 0.0102 0.0503
Brugia malayi Bromodomain containing protein 0.0038 0.0013 0.0036
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0062 0.0031 0.0161
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0294 0.02 1
Leishmania major hypothetical protein, conserved 0.0106 0.0063 1
Brugia malayi RNA recognition motif domain containing protein 0.0062 0.0031 0.013
Plasmodium falciparum JmjC domain-containing protein, putative 0.0041 0.0015 0.147
Mycobacterium tuberculosis Probable esterase LipL 0.0036 0.0012 0.0003
Plasmodium falciparum ataxin-2 like protein, putative 0.0106 0.0063 1
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.0081 0.0044 0.173
Brugia malayi jmjC domain containing protein 0.0213 0.0141 0.071
Schistosoma mansoni zinc finger protein 0.0024 0.0003 0.0104
Loa Loa (eye worm) hypothetical protein 0.0036 0.0012 0.0061
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0045 0.0018 0.0898
Loa Loa (eye worm) hypothetical protein 0.0029 0.0007 0.0035
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0031 0.1098
Brugia malayi beta-lactamase family protein 0.0036 0.0012 0.003
Mycobacterium tuberculosis Conserved protein 0.0036 0.0012 0.0003
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0041 0.0015 0.0629
Loa Loa (eye worm) hypothetical protein 0.0106 0.0063 0.0329
Echinococcus multilocularis lysosomal alpha glucosidase 0.0172 0.0111 0.0572
Onchocerca volvulus 0.0099 0.0058 0.3351
Onchocerca volvulus 0.0036 0.0012 0.0367
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0018 0.0898
Schistosoma mansoni cpg binding protein 0.0095 0.0054 0.195
Loa Loa (eye worm) hypothetical protein 0.0047 0.002 0.0102
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0039 0.0014 0.0002
Loa Loa (eye worm) jmjC domain-containing protein 0.0159 0.0102 0.0533
Onchocerca volvulus 0.0036 0.0012 0.0367
Trichomonas vaginalis ap endonuclease, putative 0.0039 0.0014 0.0685
Loa Loa (eye worm) hypothetical protein 0.0036 0.0012 0.0061
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0031 0.1098
Plasmodium vivax hypothetical protein, conserved 0.0045 0.0018 0.1976
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0012 0.0596
Trypanosoma brucei metacaspase 0.0045 0.0018 0.1185
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0045 0.0018 0.1081
Echinococcus granulosus jumonji domain containing 1A 0.0041 0.0015 0.0068
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0041 0.0015 0.0629
Brugia malayi PHD-finger family protein 0.0029 0.0007 0.0003
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0012 0.0025
Brugia malayi Inositol-1 0.0036 0.0012 0.0031
Echinococcus granulosus tar DNA binding protein 0.0062 0.0031 0.0151
Trichomonas vaginalis sucrase-isomaltase, putative 0.0038 0.0013 0.0666
Mycobacterium tuberculosis Probable lipase LipD 0.0036 0.0012 0.0003
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0064 0.0032 0.0157
Trypanosoma cruzi metacaspase, putative 0.0045 0.0018 0.1185
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0018 0.0898
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0038 0.0013 0.0068
Loa Loa (eye worm) beta-lactamase 0.0036 0.0012 0.0061
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0039 0.0014 0.1216
Loa Loa (eye worm) jmjC domain-containing protein 0.0041 0.0015 0.0078
Echinococcus multilocularis caspase 3 0.0073 0.0039 0.0193
Leishmania major metacaspase, putative 0.0045 0.0018 0.1185
Toxoplasma gondii LsmAD domain-containing protein 0.0106 0.0063 0.547
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0035 0.0011 0.0048
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0039 0.0014 0.007
Trypanosoma cruzi PAB1-binding protein , putative 0.0106 0.0063 1
Echinococcus multilocularis jumonji domain containing 1A 0.0041 0.0015 0.0068
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0039 0.0014 0.0061
Schistosoma mansoni hypothetical protein 0.0351 0.0241 0.8661
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0019 0.0674
Treponema pallidum fructose-bisphosphate aldolase 0.0294 0.02 1
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0038 0.0013 0.0074
Schistosoma mansoni ap endonuclease 0.0039 0.0014 0.0481
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0108 0.0064 0.2302
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0013 0.0666
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0294 0.02 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0012 0.0417
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0108 0.0064 0.2302
Echinococcus granulosus histone lysine methyltransferase setb 0.0049 0.0021 0.0099
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0019 0.0674
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0048 0.002 0.0094
Onchocerca volvulus 0.024 0.0161 1
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0013 0.0275
Mycobacterium leprae Probable lipase LipE 0.0036 0.0012 0.0005
Brugia malayi Glycosyl hydrolases family 31 protein 0.0172 0.0111 0.0552
Schistosoma mansoni alpha-glucosidase 0.0148 0.0093 0.3349
Echinococcus granulosus lamin dm0 0.0028 0.0006 0.0021
Echinococcus granulosus lysine specific demethylase 5A 0.0159 0.0102 0.0524
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0019 0.0089
Brugia malayi latrophilin 2 splice variant baaae 0.0038 0.0013 0.0037
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0013 0.0666
Loa Loa (eye worm) inositol-1 0.0036 0.0012 0.0062
Toxoplasma gondii melibiase subfamily protein 0.0108 0.0064 0.5609
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0007 0.0023
Onchocerca volvulus 0.0041 0.0016 0.0614
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0041 0.0015 0.0804
Echinococcus granulosus lysine specific demethylase 6a 0.0041 0.0015 0.0068
Echinococcus granulosus neutral alpha glucosidase AB 0.0038 0.0013 0.0059
Schistosoma mansoni hypothetical protein 0.0048 0.002 0.0715
Echinococcus multilocularis cpg binding protein 0.0095 0.0054 0.0276
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0048 0.002 0.0094
Echinococcus multilocularis lamin dm0 0.0028 0.0006 0.0021
Echinococcus granulosus caspase 8 0.0045 0.0018 0.0083
Echinococcus multilocularis phd:f box containing protein 0.0041 0.0015 0.0068
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0032 0.0009 0.0305
Schistosoma mansoni survival motor neuron protein 0.0049 0.0021 0.0742
Loa Loa (eye worm) hypothetical protein 0.0036 0.0012 0.0061
Schistosoma mansoni hypothetical protein 0.0402 0.0278 1
Loa Loa (eye worm) jmjC domain-containing protein 0.0061 0.003 0.0154
Brugia malayi hypothetical protein 0.0041 0.0016 0.005
Echinococcus granulosus intermediate filament protein 0.0028 0.0006 0.0021
Plasmodium vivax SET domain protein, putative 0.0032 0.0009 0.0341
Schistosoma mansoni inositol monophosphatase 0.0036 0.0012 0.0421
Echinococcus multilocularis muscleblind protein 0.2627 0.1899 1
Plasmodium vivax JmjC domain containing protein 0.0041 0.0015 0.147
Echinococcus multilocularis muscleblind protein 1 0.2627 0.1899 1
Loa Loa (eye worm) hypothetical protein 0.0238 0.0159 0.0836
Brugia malayi PHD-finger family protein 0.003 0.0007 0.0004
Echinococcus multilocularis tar DNA binding protein 0.0062 0.0031 0.0151
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0012 0.0897
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0144 0.009 0.0078
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0019 0.0674
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0013 0.0666
Echinococcus multilocularis peregrin 0.0032 0.0009 0.0034
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0144 0.009 0.0165
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.0006 0.0031
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0039 0.0014 0.035
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0294 0.02 1
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.0081 0.0044 0.173
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0012 0.0418
Loa Loa (eye worm) jmjC domain-containing protein 0.0041 0.0015 0.0078
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0072 0.0038 0.1358
Schistosoma mansoni alpha glucosidase 0.0038 0.0013 0.0467
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0294 0.02 1
Loa Loa (eye worm) hypothetical protein 0.0072 0.0038 0.0199
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0108 0.0064 0.2302
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0294 0.02 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0049 0.0021 0.0746
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0018 0.0898
Loa Loa (eye worm) hypothetical protein 0.0041 0.0015 0.0078
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0012 0.0025
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0039 0.0014 0.0094
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0032 0.0009 0.0035
Brugia malayi mucosa associated lymphoid tissue lymphoma translocation protein 1 0.0045 0.0018 0.0062
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0019 0.0089
Schistosoma mansoni inositol monophosphatase 0.0036 0.0012 0.0421
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0027 0.0005 0.0181
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0012 0.0417
Echinococcus multilocularis inositol monophosphatase 1 0.0036 0.0012 0.0052
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0035 0.0011 0.0048
Brugia malayi Pre-SET motif family protein 0.0211 0.0139 0.0704
Mycobacterium leprae conserved hypothetical protein 0.0036 0.0012 0.0005

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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