Detailed information for compound 1170917

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 251.715 | Formula: C11H14ClN5
  • H donors: 1 H acceptors: 3 LogP: 2.31 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CNCCC(n1nncn1)c1ccc(cc1)Cl
  • InChi: 1S/C11H14ClN5/c1-13-7-6-11(17-15-8-14-16-17)9-2-4-10(12)5-3-9/h2-5,8,11,13H,6-7H2,1H3
  • InChiKey: ZETREDFPVNTUBS-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0109 0.0374 0.1369
Mycobacterium ulcerans pantoate--beta-alanine ligase 0.0649 0.2533 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0022 0.0052
Plasmodium vivax amine transporter, putative 0.0024 0.0035 0.0876
Brugia malayi nuclear hormone receptor 0.0021 0.0022 0.0052
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0051 0.0142 0.0332
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0022 0.0072
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0057 0.0167 0.0165
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0021 0.0022 0.0236
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0024 0.0035 0.0128
Brugia malayi Cytochrome P450 family protein 0.0028 0.005 0.0116
Treponema pallidum sodium- and chloride- dependent transporter 0.0141 0.0502 1
Echinococcus multilocularis inositol monophosphatase 1 0.0039 0.0094 0.0092
Schistosoma mansoni inositol monophosphatase 0.0039 0.0094 0.0353
Echinococcus multilocularis sodium and chloride dependent glycine 0.0024 0.0035 0.0033
Brugia malayi Isocitrate dehydrogenase 0.0016 0.0002 0.0005
Loa Loa (eye worm) norepinephrine transporter 0.0141 0.0502 0.5382
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.0024 0.0035 0.0033
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0024 0.0035 0.0081
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0021 0.0022 0.0236
Echinococcus multilocularis serotonin transporter 0.0141 0.0502 0.05
Echinococcus granulosus sodium and chloride dependent glycine 0.0024 0.0035 0.0118
Loa Loa (eye worm) hypothetical protein 0.0141 0.0502 0.5382
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0024 0.0035 0.0081
Loa Loa (eye worm) hypothetical protein 0.0141 0.0502 0.5382
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0076 0.0242 1
Schistosoma mansoni sodium/chloride dependent transporter 0.0024 0.0035 0.0125
Mycobacterium leprae Probable pantoate--beta-alanine ligase PanC (pantothenate synthetase) (pantoate activating enzyme) 0.0649 0.2533 1
Brugia malayi photoreceptor-specific nuclear receptor 0.0021 0.0022 0.0052
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0109 0.0374 0.0874
Echinococcus granulosus histone acetyltransferase MYST2 0.0057 0.0167 0.0601
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.0053 0.0564
Plasmodium falciparum amino acid transporter, putative 0.0024 0.0035 0.1354
Onchocerca volvulus 0.0024 0.0035 0.0266
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0076 0.0242 0.0798
Mycobacterium tuberculosis Conserved protein 0.0109 0.0374 0.1369
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0021 0.0022 0.0076
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0024 0.0035 0.0128
Loa Loa (eye worm) hypothetical protein 0.0024 0.0035 0.0373
Mycobacterium ulcerans beta-lactamase 0.0109 0.0374 0.1144
Schistosoma mansoni sodium/chloride dependent transporter 0.0141 0.0502 0.1913
Loa Loa (eye worm) hypothetical protein 0.0024 0.0035 0.0373
Trypanosoma cruzi hypothetical protein, conserved 0.0109 0.0374 1
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.0024 0.0035 0.0033
Onchocerca volvulus 0.0103 0.035 0.6841
Loa Loa (eye worm) beta-lactamase 0.0109 0.0374 0.4006
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0119 0.0426
Loa Loa (eye worm) MBCTL1 0.0057 0.0167 0.1795
Brugia malayi Probable ClpP-like protease 0.0076 0.0242 0.0567
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0141 0.0502 0.1913
Loa Loa (eye worm) hypothetical protein 0.005 0.014 0.1498
Echinococcus multilocularis FTZ F1 alpha 0.0021 0.0022 0.002
Echinococcus granulosus SAM and MBT domain containing protein 0.005 0.014 0.05
Loa Loa (eye worm) hypothetical protein 0.0024 0.0035 0.0373
Echinococcus multilocularis beta LACTamase domain containing family member 0.0109 0.0374 0.0371
Brugia malayi ecdysteroid receptor 0.0021 0.0022 0.0052
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0021 0.0022 0.0076
Schistosoma mansoni retinoic acid receptor RXR 0.0021 0.0022 0.0076
Brugia malayi Intermediate filament tail domain containing protein 0.0028 0.0053 0.0123
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0022 0.0052
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0021 0.0022 0.0072
Schistosoma mansoni intermediate filament proteins 0.0028 0.0053 0.0193
Brugia malayi beta-lactamase family protein 0.0109 0.0374 0.0874
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0076 0.0242 1
Brugia malayi mbt repeat family protein 0.005 0.014 0.0327
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0021 0.0022 0.0052
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0021 0.0022 0.0072
Echinococcus granulosus tumor protein p63 0.0703 0.2747 1
Echinococcus granulosus microtubule associated protein 2 0.0669 0.2614 0.9516
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0021 0.0022 0.0072
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0021 0.0022 0.002
Echinococcus multilocularis peptidase Clp (S14 family) 0.005 0.0138 0.0136
Onchocerca volvulus 0.0109 0.0374 0.7327
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0021 0.0022 0.0072
Trichomonas vaginalis penicillin-binding protein, putative 0.0109 0.0374 1
Onchocerca volvulus 0.0028 0.0053 0.0636
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0022 0.0052
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0024 0.0035 0.0125
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0094 0.2482
Onchocerca volvulus 0.0141 0.0502 1
Plasmodium falciparum transporter, putative 0.0024 0.0035 0.1354
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0094 0.2482
Mycobacterium ulcerans hypothetical protein 0.0109 0.0374 0.1144
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.005 0.014 0.0526
Brugia malayi beta-lactamase family protein 0.0109 0.0374 0.0874
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0024 0.0035 0.0125
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0021 0.0022 0.0076
Trichomonas vaginalis D-aminoacylase, putative 0.0109 0.0374 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0021 0.0022 0.0236
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0119 0.1277
Echinococcus multilocularis musashi 0.0028 0.0053 0.005
Loa Loa (eye worm) mbt repeat family protein 0.005 0.014 0.1498
Echinococcus multilocularis microtubule associated protein 2 0.0669 0.2614 0.2612
Schistosoma mansoni lamin 0.0028 0.0053 0.0193
Mycobacterium tuberculosis Conserved protein 0.0109 0.0374 0.1369
Echinococcus granulosus intermediate filament protein 0.0028 0.0053 0.0183
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0021 0.0022 0.0072
Echinococcus granulosus polycomb protein SCMH1 0.005 0.014 0.05
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0021 0.0022 0.0052
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0141 0.0502 0.1174
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0094 0.2482
Trypanosoma cruzi hypothetical protein, conserved 0.0109 0.0374 1
Schistosoma mansoni thyroid hormone receptor 0.0021 0.0022 0.0076
Echinococcus multilocularis survival motor neuron protein 1 0.0249 0.0932 0.093
Loa Loa (eye worm) hypothetical protein 0.0021 0.0022 0.0236
Loa Loa (eye worm) inositol-1 0.0039 0.0094 0.1013
Brugia malayi hypothetical protein 0.0024 0.0035 0.0081
Loa Loa (eye worm) hypothetical protein 0.0024 0.0035 0.0373
Schistosoma mansoni RAR-like nuclear receptor 0.0021 0.0022 0.0076
Schistosoma mansoni survival motor neuron protein 0.0051 0.0142 0.0535
Echinococcus granulosus sodium and chloride dependent glycine 0.0024 0.0035 0.0118
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0119 0.0447
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0024 0.0035 0.0118
Loa Loa (eye worm) hypothetical protein 0.0021 0.0022 0.0236
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0198 0.0729 0.0727
Loa Loa (eye worm) hypothetical protein 0.0024 0.0035 0.0373
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0076 0.0242 0.0607
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0024 0.0035 0.0373
Mycobacterium tuberculosis Probable esterase LipL 0.0109 0.0374 0.1369
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0021 0.0022 0.0076
Trypanosoma brucei hypothetical protein, conserved 0.0109 0.0374 1
Schistosoma mansoni inositol monophosphatase 0.0039 0.0094 0.0353
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0022 0.0072
Echinococcus granulosus peptidase Clp S14 family 0.005 0.0138 0.0494
Loa Loa (eye worm) hypothetical protein 0.0109 0.0374 0.4006
Brugia malayi steroid hormone receptor 0.0021 0.0022 0.0052
Brugia malayi intermediate filament protein 0.0028 0.0053 0.0123
Loa Loa (eye worm) hypothetical protein 0.0141 0.0502 0.5382
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0109 0.0374 0.1369
Schistosoma mansoni hypothetical protein 0.0305 0.1157 0.4422
Echinococcus multilocularis polycomb protein SCMH1 0.005 0.014 0.0137
Echinococcus multilocularis SAM and MBT domain containing protein 0.005 0.014 0.0137
Leishmania major hypothetical protein, conserved 0.0109 0.0374 1
Loa Loa (eye worm) hypothetical protein 0.0109 0.0374 0.4006
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0024 0.0035 0.0125
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.0022 0.0052
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0024 0.0035 0.0125
Brugia malayi Serotonin receptor 0.1085 0.4273 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0022 0.0236
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.005 0.0138 0.0379
Echinococcus granulosus survival motor neuron protein 1 0.0249 0.0932 0.3389
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.0024 0.0035 0.0118
Brugia malayi Steroid receptor seven-up type 2 0.0021 0.0022 0.0052
Toxoplasma gondii hypothetical protein 0.0026 0.0044 0.0164
Loa Loa (eye worm) hypothetical protein 0.0076 0.0242 0.26
Mycobacterium tuberculosis Probable lipase LipD 0.0109 0.0374 0.1369
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0076 0.0242 0.0607
Plasmodium vivax hypothetical protein, conserved 0.0109 0.0374 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0119 0.0447
Echinococcus granulosus neuropeptide s receptor 0.0462 0.1784 0.6494
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0119 0.0447
Echinococcus multilocularis lamin dm0 0.0028 0.0053 0.005
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0109 0.0374 0.1422
Loa Loa (eye worm) hypothetical protein 0.0109 0.0374 0.4006
Loa Loa (eye worm) intermediate filament protein 0.0028 0.0053 0.0564
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0021 0.0022 0.0236
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0021 0.0022 0.0236
Schistosoma mansoni cellular tumor antigen P53 0.0103 0.035 0.1332
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0024 0.0035 0.0373
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0024 0.0035 0.0081
Brugia malayi hypothetical protein 0.0249 0.0932 0.2182
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0024 0.0035 0.0125
Echinococcus granulosus serotonin transporter 0.0141 0.0502 0.182
Schistosoma mansoni coup transcription factor 0.0021 0.0022 0.0076
Echinococcus multilocularis neuropeptide receptor A26 0.0462 0.1784 0.1783
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.005 0.0138 0.0501
Loa Loa (eye worm) hypothetical protein 0.0028 0.0051 0.0542
Onchocerca volvulus 0.005 0.014 0.2451
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0026 0.0044 0.1117
Echinococcus granulosus FTZ F1 alpha 0.0021 0.0022 0.0072
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0024 0.0035 0.0125
Toxoplasma gondii pantoate-beta-alanine ligase 0.0649 0.2533 1
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0076 0.0242 0.024
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0021 0.0022 0.0076
Loa Loa (eye worm) hypothetical protein 0.0021 0.0022 0.0236
Onchocerca volvulus 0.0028 0.0053 0.0636
Mycobacterium tuberculosis Pantoate--beta-alanine ligase PanC (pantothenate synthetase) (pantoate activating enzyme) 0.0649 0.2533 0.9335
Mycobacterium leprae conserved hypothetical protein 0.0109 0.0374 0.1325
Toxoplasma gondii hypothetical protein 0.0024 0.0035 0.0128
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.0024 0.0035 0.0033
Echinococcus multilocularis sodium and chloride dependent glycine 0.0024 0.0035 0.0033
Trichomonas vaginalis penicillin-binding protein, putative 0.0109 0.0374 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0022 0.002
Brugia malayi Inositol-1 0.0039 0.0094 0.0221
Loa Loa (eye worm) hypothetical protein 0.0024 0.0035 0.0373
Toxoplasma gondii hypothetical protein 0.0024 0.0035 0.0128
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0057 0.0167 0.0392
Schistosoma mansoni sodium-dependent amino acid transporter 0.0024 0.0035 0.0125
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0024 0.0035 0.0118
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0021 0.0022 0.0076
Schistosoma mansoni lamin 0.0028 0.0053 0.0193
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0022 0.0052
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0119 0.0117
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0021 0.0022 0.002
Mycobacterium tuberculosis Probable lipase LipE 0.0109 0.0374 0.1369
Brugia malayi isocitrate dehydrogenase 0.0016 0.0002 0.0005
Echinococcus multilocularis neuropeptide s receptor 0.0462 0.1784 0.1783
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0076 0.0242 0.4337
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0094 0.2482
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0021 0.0022 0.0236
Echinococcus multilocularis tumor protein p63 0.0703 0.2747 0.2745
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0021 0.0022 0.002
Schistosoma mansoni sex comb on midleg homolog 0.005 0.014 0.0526
Loa Loa (eye worm) hypothetical protein 0.0021 0.0022 0.0236
Trichomonas vaginalis D-aminoacylase, putative 0.0109 0.0374 1
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0039 0.0094 0.0364
Echinococcus granulosus lamin dm0 0.0028 0.0053 0.0183
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0109 0.0374 0.1422
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0119 0.0279
Loa Loa (eye worm) hypothetical protein 0.0021 0.0022 0.0236
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0021 0.0022 0.002
Mycobacterium tuberculosis Probable hydrolase 0.0109 0.0374 0.1369
Brugia malayi mbt repeat family protein 0.005 0.014 0.0327
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0024 0.0035 0.0128
Schistosoma mansoni steroid hormone receptor ad4bp 0.0021 0.0022 0.0076
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0076 0.0242 0.6468
Brugia malayi nuclear receptor NHR-88 0.0021 0.0022 0.0052
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0057 0.0167 0.0601
Loa Loa (eye worm) hypothetical protein 0.0109 0.0374 0.4006
Echinococcus multilocularis ecdysone induced protein 78C 0.0021 0.0022 0.002
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.0024 0.0035 0.0081
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0109 0.0374 0.4006
Loa Loa (eye worm) hypothetical protein 0.0109 0.0374 0.4006
Schistosoma mansoni thyroid hormone receptor 0.0021 0.0022 0.0076
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0198 0.0729 0.2647
Echinococcus granulosus inositol monophosphatase 1 0.0039 0.0094 0.0336
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0076 0.0242 0.0875
Schistosoma mansoni sodium/chloride dependent transporter 0.0024 0.0035 0.0125
Loa Loa (eye worm) serotonin transporter b 0.0141 0.0502 0.5382
Mycobacterium ulcerans lipase LipD 0.0109 0.0374 0.1144
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0076 0.0242 0.0949
Mycobacterium leprae Probable lipase LipE 0.0109 0.0374 0.1325
Echinococcus granulosus lamin 0.0028 0.0053 0.0183
Onchocerca volvulus 0.0051 0.0142 0.2498
Loa Loa (eye worm) cytochrome P450 family protein 0.0028 0.005 0.0534
Loa Loa (eye worm) hypothetical protein 0.0024 0.0035 0.0373
Echinococcus multilocularis thyroid hormone receptor alpha 0.0021 0.0022 0.002
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0035 0.0078 0.028
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0039 0.0094 0.5
Loa Loa (eye worm) hypothetical protein 0.0249 0.0932 1
Loa Loa (eye worm) hypothetical protein 0.0109 0.0374 0.4006
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0119 0.0426
Schistosoma mansoni microtubule-associated protein tau 0.0669 0.2614 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0119 0.0117
Schistosoma mansoni myelin transcription factor 1 myt1 0.0057 0.0167 0.0632
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0.0002 0.0025
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0035 0.0078 0.0138
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0076 0.0242 0.0949
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0076 0.0242 1
Echinococcus granulosus beta LACTamase domain containing family member 0.0109 0.0374 0.1353
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0076 0.0242 1
Schistosoma mansoni hypothetical protein 0.0051 0.0142 0.0535
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0022 0.0052
Trichomonas vaginalis esterase, putative 0.0109 0.0374 1
Plasmodium vivax hypothetical protein, conserved 0.0024 0.0035 0.0876
Loa Loa (eye worm) hypothetical protein 0.0028 0.0053 0.0564
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0021 0.0022 0.0052
Mycobacterium ulcerans esterase/lipase LipP 0.0109 0.0374 0.1144
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.005 0.014 0.2451
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0021 0.0022 0.0052
Loa Loa (eye worm) solute carrier family 6 member 4 0.0141 0.0502 0.5382
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0024 0.0035 0.0125
Echinococcus granulosus neuropeptide receptor A26 0.0462 0.1784 0.6494
Loa Loa (eye worm) hypothetical protein 0.0057 0.0167 0.1795
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0109 0.0374 0.1144
Loa Loa (eye worm) hypothetical protein 0.0103 0.035 0.3757
Loa Loa (eye worm) steroid hormone receptor 0.0021 0.0022 0.0236
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.0024 0.0035 0.0118
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0021 0.0022 0.0052
Schistosoma mansoni sex comb on midleg homolog 0.005 0.014 0.0526
Echinococcus multilocularis histone acetyltransferase MYST2 0.0057 0.0167 0.0165
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0021 0.0022 0.0052
Onchocerca volvulus 0.0024 0.0035 0.0266
Schistosoma mansoni peptidase Clp (S14 family) 0.0076 0.0242 0.0919
Echinococcus granulosus ecdysone induced protein 78C 0.0021 0.0022 0.0072
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0026 0.0044 0.1727
Onchocerca volvulus 0.0109 0.0374 0.7327
Onchocerca volvulus 0.0024 0.0035 0.0266
Mycobacterium tuberculosis Conserved protein 0.0109 0.0374 0.1369
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0022 0.002
Brugia malayi beta-lactamase 0.0109 0.0374 0.0874
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0694 0.2713 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0021 0.0022 0.0236
Onchocerca volvulus 0.0109 0.0374 0.7327
Trichomonas vaginalis D-aminoacylase, putative 0.0109 0.0374 1
Schistosoma mansoni nuclear hormone receptor 0.0021 0.0022 0.0076
Toxoplasma gondii ABC1 family protein 0.0109 0.0374 0.1467
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0109 0.0374 0.1369
Loa Loa (eye worm) hypothetical protein 0.0021 0.0022 0.0236
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.005 0.0138 0.0501
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0024 0.0035 0.0125
Echinococcus multilocularis lamin 0.0028 0.0053 0.005
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0022 0.0052
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0021 0.0022 0.0052
Loa Loa (eye worm) hypothetical protein 0.0021 0.0022 0.0236

Activities

Activity type Activity value Assay description Source Reference
Inhibition (binding) = 41.1 % Displacement of [3H]paroxetine from SERT in rat cerebral cortex at 1 uM ChEMBL. 20724153

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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