Detailed information for compound 1177914

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 1421.55 | Formula: C68H92N16O18
  • H donors: 16 H acceptors: 18 LogP: -0.38 Rotable bonds: 16
    Rule of 5 violations (Lipinski): 4
  • SMILES: OC[C@@H]1NC(=O)[C@@H]2C[C@@]3([C@@H](N2C(=O)[C@H](CC(=O)N)NC(=O)[C@H](CC(=O)N)NC(=O)[C@H](CC(=O)O)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@H]2N(C(=O)[C@H]4N(C(=O)[C@@H](NC1=O)[C@H](O)C)CCC4)[C@@H]1Nc4c([C@@]1(C2)CC=C(C)C)cccc4)CC(C)C)CC(=O)N)Nc1c3cccc1)CC=C(C)C
  • InChi: 1S/C68H92N16O18/c1-32(2)18-20-67-28-47-61(99)78-45(31-85)59(97)81-54(35(7)86)64(102)82-22-12-17-46(82)63(101)84-48(29-68(21-19-33(3)4)37-14-9-11-16-39(37)80-66(68)84)60(98)76-40(23-34(5)6)56(94)74-41(24-49(69)87)55(93)72-30-52(90)73-43(27-53(91)92)58(96)75-42(25-50(70)88)57(95)77-44(26-51(71)89)62(100)83(47)65(67)79-38-15-10-8-13-36(38)67/h8-11,13-16,18-19,34-35,40-48,54,65-66,79-80,85-86H,12,17,20-31H2,1-7H3,(H2,69,87)(H2,70,88)(H2,71,89)(H,72,93)(H,73,90)(H,74,94)(H,75,96)(H,76,98)(H,77,95)(H,78,99)(H,81,97)(H,91,92)/t35-,40-,41+,42+,43+,44+,45+,46+,47+,48+,54+,65-,66+,67+,68+/m1/s1
  • InChiKey: SZGKSIQFXTWZJY-MHYXRNQBSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis tubulin alpha chain 0.0388 0.733 0.733
Trichomonas vaginalis tubulin epsilon chain, putative 0.0134 0.2421 0.2421
Echinococcus granulosus TGF beta signal transducer SmadC 0.0009 0.0024 0.0024
Echinococcus granulosus tubulin delta chain 0.0134 0.2421 0.2421
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0015 0.0136 0.0136
Loa Loa (eye worm) hypothetical protein 0.0015 0.0136 0.013
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0159 0.292 0.267
Echinococcus multilocularis mothers against decapentaplegic 5 0.0009 0.0024 0.0024
Leishmania major alpha tubulin 0.0388 0.733 0.731
Echinococcus multilocularis tubulin delta chain 0.0134 0.2421 0.2421
Trichomonas vaginalis conserved hypothetical protein 0.0134 0.2421 0.2421
Loa Loa (eye worm) alpha-tubulin 0.0388 0.733 0.7328
Loa Loa (eye worm) hypothetical protein 0.0048 0.0772 0.0766
Schistosoma mansoni hypothetical protein 0.0015 0.0136 0.0136
Giardia lamblia Gamma tubulin 0.0318 0.5983 0.5635
Loa Loa (eye worm) tubulin alpha-2 chain 0.0388 0.733 0.7328
Trypanosoma cruzi tubulin gamma chain 0.0318 0.5983 0.5954
Trichomonas vaginalis tubulin gamma chain, putative 0.0318 0.5975 0.5975
Trypanosoma brucei alpha tubulin 0.0388 0.733 0.731
Echinococcus multilocularis voltage gated potassium channel 0.001 0.0042 0.0042
Schistosoma mansoni RAR-like nuclear receptor 0.001 0.0031 0.0031
Toxoplasma gondii alpha-tubulin I, putative 0.0388 0.733 0.7235
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0044 0.0695 0.0689
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0064 0.1079 0.1057
Echinococcus multilocularis muscleblind protein 0.0169 0.3106 0.3106
Trichomonas vaginalis tubulin beta chain, putative 0.0388 0.733 0.733
Schistosoma mansoni serine/threonine protein kinase 0.0049 0.0797 0.0797
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.001 0.0031 0.0031
Brugia malayi Calcitonin receptor-like protein seb-1 0.0048 0.0772 0.0749
Loa Loa (eye worm) tubulin alpha 2 0.0254 0.4751 0.4747
Brugia malayi Nuclear hormone receptor family member nhr-40 0.001 0.0031 0.0007
Schistosoma mansoni tubulin subunit beta 0.0134 0.2421 0.2421
Plasmodium vivax tubulin alpha chain, putative 0.0388 0.733 0.6477
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0015 0.0136 0.0136
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0049 0.0797 0.073
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0064 0.1079 0.1079
Plasmodium falciparum tubulin gamma chain 0.0318 0.5983 0.47
Brugia malayi Tubulin gamma chain 0.0318 0.5983 0.5973
Echinococcus granulosus mothers against decapentaplegic 5 0.0009 0.0024 0.0024
Trypanosoma cruzi zeta tubulin, putative 0.0405 0.765 0.7633
Brugia malayi Nuclear hormone receptor family member nhr-41 0.001 0.0031 0.0007
Brugia malayi MAP kinase sur-1 0.0049 0.0797 0.0775
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0695 0.0695
Loa Loa (eye worm) transcription factor SMAD2 0.0139 0.2519 0.2515
Echinococcus granulosus Tubulin alpha 1 chain 0.0388 0.733 0.733
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0064 0.1079 0.1079
Schistosoma mansoni voltage-gated potassium channel 0.001 0.0042 0.0042
Leishmania major alpha tubulin 0.0388 0.733 0.731
Schistosoma mansoni tubulin subunit epsilon 0.0318 0.5975 0.5975
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0031 0.0007
Brugia malayi tubulin alpha-2 chain 0.0388 0.733 0.7323
Trichomonas vaginalis CMGC family protein kinase 0.0049 0.0797 0.0797
Schistosoma mansoni tubulin subunit delta 0.0134 0.2421 0.2421
Brugia malayi Nuclear hormone receptor family member nhr-3 0.001 0.0031 0.0007
Loa Loa (eye worm) hypothetical protein 0.0031 0.0442 0.0436
Trichomonas vaginalis tubulin beta-1 chain, putative 0.0134 0.2421 0.2421
Echinococcus multilocularis hypothetical protein 0.0388 0.733 0.733
Trichomonas vaginalis CMGC family protein kinase 0.0049 0.0797 0.0797
Mycobacterium tuberculosis Cell division protein FtsZ 0.0134 0.2421 1
Echinococcus multilocularis Tubulin alpha 1 chain 0.0388 0.733 0.733
Schistosoma mansoni alpha tubulin 0.0388 0.733 0.733
Giardia lamblia Alpha-tubulin 0.0388 0.733 0.7098
Schistosoma mansoni Tr4/Tr2 (homologue) 0.001 0.0031 0.0031
Brugia malayi tubulin alpha chain - mouse 0.0388 0.733 0.7323
Trichomonas vaginalis tubulin alpha chain, putative 0.0158 0.2897 0.2897
Loa Loa (eye worm) MH2 domain-containing protein 0.0139 0.2519 0.2515
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.001 0.0031 0.0031
Schistosoma mansoni hypothetical protein 0.0015 0.0136 0.0136
Brugia malayi follicle stimulating hormone receptor 0.0225 0.4183 0.4169
Echinococcus multilocularis mitogen activated protein kinase 0.0049 0.0797 0.0797
Loa Loa (eye worm) tubulin alpha chain 0.0388 0.733 0.7328
Trichomonas vaginalis tubulin alpha chain, putative 0.0158 0.2897 0.2897
Plasmodium falciparum tubulin epsilon chain, putative 0.0318 0.5975 0.469
Trichomonas vaginalis conserved hypothetical protein 0.0134 0.2421 0.2421
Trichomonas vaginalis tubulin alpha chain, putative 0.0158 0.2897 0.2897
Echinococcus granulosus tubulin alpha 1C chain 0.0388 0.733 0.733
Loa Loa (eye worm) tubulin alpha chain 0.0388 0.733 0.7328
Loa Loa (eye worm) hypothetical protein 0.001 0.0042 0.0036
Brugia malayi MH2 domain containing protein 0.0139 0.2519 0.2501
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0009 0.0024 0.0024
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0695 0.0695
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0064 0.1079 0.1014
Echinococcus multilocularis smad 0.0009 0.0024 0.0024
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0064 0.1079 0.1079
Echinococcus granulosus FTZ F1 alpha 0.001 0.0031 0.0031
Schistosoma mansoni Smad4 0.0009 0.0024 0.0024
Brugia malayi alpha-tubulin 0.0388 0.733 0.7323
Loa Loa (eye worm) tubulin beta chain 0.0134 0.2421 0.2416
Echinococcus multilocularis Smad4 0.0009 0.0024 0.0024
Schistosoma mansoni tubulin subunit gamma 0.0318 0.5983 0.5983
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0031 0.0031
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.001 0.0031 0.0025
Loa Loa (eye worm) tubulin alpha 2 0.0254 0.4751 0.4747
Echinococcus multilocularis tubulin alpha 3 chain 0.0388 0.733 0.733
Trypanosoma brucei beta tubulin 0.0292 0.5476 0.5443
Echinococcus multilocularis transcription factor Dp 1 0.0037 0.0558 0.0558
Trichomonas vaginalis tubulin alpha chain, putative 0.0292 0.5476 0.5476
Echinococcus multilocularis muscleblind protein 1 0.0169 0.3106 0.3106
Brugia malayi Muscleblind-like protein 0.0169 0.3106 0.3089
Plasmodium vivax tubulin gamma chain, putative 0.0318 0.5983 0.47
Leishmania major epsilon tubulin, putative 0.0318 0.5975 0.5946
Trypanosoma brucei zeta tubulin 0.0405 0.765 0.7633
Leishmania major delta tubulin, putative 0.0296 0.5549 0.5516
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0049 0.0797 0.0791
Brugia malayi Latrophilin receptor protein 2 0.0015 0.0136 0.0112
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0064 0.1079 0.1014
Echinococcus multilocularis tubulin alpha chain 0.0388 0.733 0.733
Brugia malayi Cytochrome P450 family protein 0.0012 0.0072 0.0048
Echinococcus granulosus potassium voltage gated channel subfamily H 0.001 0.0042 0.0042
Trypanosoma cruzi tubulin delta chain 0.0296 0.5549 0.5516
Loa Loa (eye worm) MH2 domain-containing protein 0.0009 0.0024 0.0018
Echinococcus granulosus tubulin alpha chain 0.0388 0.733 0.733
Echinococcus granulosus GPCR family 2 0.0015 0.0136 0.0136
Trichomonas vaginalis tubulin epsilon chain, putative 0.0388 0.733 0.733
Giardia lamblia Epsilon tubulin 0.0159 0.292 0.2307
Trypanosoma brucei epsilon tubulin 0.0318 0.5975 0.5946
Schistosoma mansoni voltage-gated potassium channel 0.0039 0.0597 0.0597
Wolbachia endosymbiont of Brugia malayi cell division protein FtsZ 0.0134 0.2421 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.001 0.0031 0.0025
Brugia malayi Nuclear hormone receptor family member nhr-49 0.001 0.0031 0.0007
Trichomonas vaginalis tubulin beta chain, putative 0.0388 0.733 0.733
Trichomonas vaginalis tubulin beta chain, putative 0.0388 0.733 0.733
Treponema pallidum cell division protein FtsZ 0.0134 0.2421 1
Leishmania major alpha tubulin 0.0388 0.733 0.731
Schistosoma mansoni voltage-gated potassium channel 0.0039 0.0597 0.0597
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0695 0.0695
Echinococcus granulosus tubulin alpha chain 0.0388 0.733 0.733
Schistosoma mansoni hypothetical protein 0.0015 0.0136 0.0136
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0041 0.0628 0.0628
Brugia malayi Tubulin alpha chain 0.0134 0.2421 0.2403
Loa Loa (eye worm) alpha-tubulin 0.0388 0.733 0.7328
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0044 0.0695 0.0672
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0049 0.0797 0.073
Brugia malayi Tubulin beta chain 0.0134 0.2421 0.2403
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.001 0.0042 0.0018
Leishmania major alpha tubulin 0.0388 0.733 0.731
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0031 0.0007
Mycobacterium leprae cell division protein FtsZ 0.0134 0.2421 1
Echinococcus multilocularis tubulin alpha 1C chain 0.0388 0.733 0.733
Brugia malayi Cell division protein ftsZ 0.0134 0.2421 0.2403
Schistosoma mansoni alpha tubulin 0.0388 0.733 0.733
Trypanosoma brucei epsilon tubulin 0.0318 0.5975 0.5946
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.001 0.0031 0.0031
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0036 0.0533 0.0527
Echinococcus multilocularis tubulin alpha 1C chain 0.0388 0.733 0.733
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.023 0.4274 0.4274
Trypanosoma brucei epsilon tubulin 0.0292 0.5476 0.5443
Plasmodium falciparum alpha tubulin 1 0.0388 0.733 0.6477
Trypanosoma brucei zeta tubulin, putative 0.0405 0.765 0.7633
Schistosoma mansoni voltage-gated potassium channel 0.001 0.0042 0.0042
Echinococcus granulosus mitogen activated protein kinase 0.0049 0.0797 0.0797
Loa Loa (eye worm) hypothetical protein 0.0388 0.733 0.7328
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.001 0.0031 0.0031
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0048 0.0772 0.0749
Brugia malayi nuclear receptor NHR-88 0.001 0.0031 0.0007
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0031 0.0031
Echinococcus granulosus retinoic acid receptor rxr beta a 0.001 0.0031 0.0031
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0064 0.1079 0.1074
Trichomonas vaginalis tubulin beta chain, putative 0.0388 0.733 0.733
Echinococcus granulosus ecdysone induced protein 78C 0.001 0.0031 0.0031
Plasmodium falciparum alpha tubulin 2 0.0388 0.733 0.6477
Schistosoma mansoni smad1 5 8 and 0.0009 0.0024 0.0024
Trypanosoma cruzi tubulin delta chain 0.0296 0.5549 0.5516
Schistosoma mansoni nuclear hormone receptor 0.001 0.0031 0.0031
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0009 0.0024 0.0024
Loa Loa (eye worm) tubulin gamma chain 0.0318 0.5983 0.598
Echinococcus multilocularis ecdysone induced protein 78C 0.001 0.0031 0.0031
Giardia lamblia Delta tubulin 0.0134 0.2421 0.1765
Loa Loa (eye worm) cytochrome P450 family protein 0.0012 0.0072 0.0066
Echinococcus granulosus Tubulin alpha 1 chain 0.0388 0.733 0.733
Echinococcus multilocularis FTZ F1 alpha 0.001 0.0031 0.0031
Schistosoma mansoni steroid hormone receptor ad4bp 0.001 0.0031 0.0031
Trypanosoma cruzi epsilon tubulin, putative 0.0318 0.5975 0.5946
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0015 0.0136 0.0136
Trichomonas vaginalis tubulin beta chain, putative 0.0388 0.733 0.733
Echinococcus multilocularis thyroid hormone receptor alpha 0.001 0.0031 0.0031
Leishmania major alpha tubulin 0.0388 0.733 0.731
Loa Loa (eye worm) hypothetical protein 0.001 0.0031 0.0025
Brugia malayi steroid hormone receptor 0.001 0.0031 0.0007
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0254 0.4751 0.4751
Trichomonas vaginalis tubulin, putative 0.0158 0.2897 0.2897
Echinococcus granulosus peroxisome assembly protein 26 0.0388 0.733 0.733
Brugia malayi Nuclear hormone receptor family member nhr-1 0.001 0.0031 0.0007
Loa Loa (eye worm) hypothetical protein 0.023 0.4274 0.4271
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.001 0.0031 0.0025
Loa Loa (eye worm) hypothetical protein 0.001 0.0031 0.0025
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0031 0.0031
Loa Loa (eye worm) hypothetical protein 0.001 0.0031 0.0025
Schistosoma mansoni hypothetical protein 0.0015 0.0136 0.0136
Loa Loa (eye worm) alpha-tubulin isotype 2 0.0254 0.4751 0.4747
Echinococcus multilocularis tubulin subunit TubB 0.0388 0.733 0.733
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0041 0.0628 0.0628
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.001 0.0031 0.0031
Loa Loa (eye worm) hypothetical protein 0.0254 0.4751 0.4747
Leishmania major alpha tubulin 0.0388 0.733 0.731
Echinococcus granulosus tubulin alpha chain 0.0388 0.733 0.733
Schistosoma mansoni alpha tubulin 0.0388 0.733 0.733
Brugia malayi Cytochrome P450 family protein 0.0012 0.0072 0.0048
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.001 0.0031 0.0025
Brugia malayi Tubulin alpha chain 0.0388 0.733 0.7323
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0048 0.0772 0.0766
Loa Loa (eye worm) hypothetical protein 0.0169 0.3106 0.3102
Echinococcus granulosus tubulin alpha 0.0292 0.5476 0.5476
Trichomonas vaginalis tubulin beta chain, putative 0.0388 0.733 0.733
Schistosoma mansoni thyroid hormone receptor 0.001 0.0031 0.0031
Loa Loa (eye worm) MH1 domain-containing protein 0.0009 0.0024 0.0018
Loa Loa (eye worm) Smad1 0.0009 0.0024 0.0018
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0012 0.0072 0.0299
Trypanosoma brucei alpha tubulin 0.0388 0.733 0.731
Leishmania major alpha tubulin 0.0388 0.733 0.731
Echinococcus granulosus tubulin alpha 3 chain 0.0388 0.733 0.733
Loa Loa (eye worm) hypothetical protein 0.001 0.0031 0.0025
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0033 0.0488 0.0488
Trichomonas vaginalis tubulin gamma chain, putative 0.0318 0.5983 0.5983
Schistosoma mansoni smad1 5 8 and 0.0009 0.0024 0.0024
Schistosoma mansoni hypothetical protein 0.0197 0.3642 0.3642
Loa Loa (eye worm) hypothetical protein 0.001 0.0031 0.0025
Leishmania major alpha tubulin 0.0388 0.733 0.731
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.001 0.0031 0.0031
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0064 0.1079 0.0481
Trypanosoma brucei tubulin delta chain 0.0296 0.5549 0.5516
Echinococcus granulosus alpha tubulin 0.0388 0.733 0.733
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.001 0.0031 0.0025
Schistosoma mansoni tubulin subunit alpha 0.0388 0.733 0.733
Echinococcus multilocularis Tubulin alpha 1 chain 0.0388 0.733 0.733
Trypanosoma brucei protein kinase, putative 0.0049 0.0797 0.073
Trypanosoma brucei tubulin gamma chain 0.0318 0.5983 0.5954
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0695 0.0695
Trichomonas vaginalis CMGC family protein kinase 0.0049 0.0797 0.0797
Echinococcus granulosus muscleblind protein 0.0169 0.3106 0.3106
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0031 0.0007
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0031 0.0007
Trichomonas vaginalis tubulin epsilon chain, putative 0.0388 0.733 0.733
Echinococcus multilocularis tubulin alpha 0.0292 0.5476 0.5476
Leishmania major gamma-tubulin 0.0318 0.5983 0.5954
Schistosoma mansoni tubulin subunit alpha 0.0388 0.733 0.733
Loa Loa (eye worm) tubulin alpha 2 0.0096 0.1695 0.169
Echinococcus multilocularis tubulin epsilon chain 0.0318 0.5975 0.5975
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.001 0.0031 0.0025
Entamoeba histolytica tubulin gamma chain 0.0318 0.5983 0.5714
Loa Loa (eye worm) steroid hormone receptor 0.001 0.0031 0.0025
Echinococcus granulosus Tubulin alpha 1 chain 0.0388 0.733 0.733
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.001 0.0031 0.0031
Schistosoma mansoni hypothetical protein 0.0033 0.0477 0.0477
Echinococcus granulosus tubulin alpha 1C chain 0.0388 0.733 0.733
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0158 0.2897 0.2897
Loa Loa (eye worm) hypothetical protein 0.001 0.0031 0.0025
Loa Loa (eye worm) latrophilin receptor protein 2 0.0015 0.0136 0.013
Echinococcus granulosus Smad4 0.0009 0.0024 0.0024
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.001 0.0042 0.0042
Echinococcus granulosus geminin 0.0197 0.3642 0.3642
Echinococcus multilocularis geminin 0.0197 0.3642 0.3642
Entamoeba histolytica tubulin alpha chain, putative 0.0388 0.733 0.7151
Schistosoma mansoni smad 0.0009 0.0024 0.0024
Trichomonas vaginalis tubulin, putative 0.0158 0.2897 0.2897
Giardia lamblia Alpha-tubulin 0.0388 0.733 0.7098
Echinococcus multilocularis Tubulin alpha 1 chain 0.0388 0.733 0.733
Leishmania major alpha tubulin 0.0388 0.733 0.731
Loa Loa (eye worm) CYP4Cod1 0.0012 0.0072 0.0066
Schistosoma mansoni hypothetical protein 0.0197 0.3642 0.3642
Loa Loa (eye worm) hypothetical protein 0.001 0.0031 0.0025
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0036 0.0533 0.0533
Brugia malayi Tubulin beta chain 0.0158 0.2897 0.288
Brugia malayi Nuclear hormone receptor family member nhr-31 0.001 0.0031 0.0007
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.001 0.0031 0.0031
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0031 0.0007
Echinococcus multilocularis mitogen activated protein kinase 3 0.0049 0.0797 0.0797
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.001 0.0031 0.0031
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.001 0.0031 0.0031
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0477 0.0454
Leishmania major zeta tubulin, putative 0.0405 0.765 0.7633
Brugia malayi Nuclear hormone receptor family member nhr-14 0.001 0.0031 0.0007
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0049 0.0797 0.073
Schistosoma mansoni smad1 5 8 and 0.0009 0.0024 0.0024
Mycobacterium ulcerans cell division protein FtsZ 0.0134 0.2421 1
Trypanosoma cruzi epsilon tubulin, putative 0.0318 0.5975 0.5946
Leishmania major alpha tubulin 0.0388 0.733 0.731
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0049 0.0797 0.073
Trichomonas vaginalis CMGC family protein kinase 0.0049 0.0797 0.0797
Echinococcus multilocularis GPCR, family 2 0.0015 0.0136 0.0136
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.0031 0.0031
Leishmania major alpha tubulin 0.0388 0.733 0.731
Echinococcus granulosus tubulin alpha 3 chain 0.0388 0.733 0.733
Loa Loa (eye worm) tubulin alpha-3 chain 0.023 0.4274 0.4271
Schistosoma mansoni coup transcription factor 0.001 0.0031 0.0031
Echinococcus multilocularis tubulin alpha chain 0.0388 0.733 0.733
Trichomonas vaginalis tubulin beta chain, putative 0.0158 0.2897 0.2897
Brugia malayi photoreceptor-specific nuclear receptor 0.001 0.0031 0.0007
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0049 0.0797 0.073
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.001 0.0031 0.0025
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0031 0.0031
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.001 0.0031 0.0031
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0695 0.0695
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0064 0.1079 0.1014
Loa Loa (eye worm) hypothetical protein 0.001 0.0031 0.0025
Toxoplasma gondii alpha tubulin TUBA1 0.0388 0.733 0.7235
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0296 0.5549 0.5392
Trypanosoma brucei alpha tubulin, putative 0.0158 0.2897 0.2845
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0695 0.0695
Onchocerca volvulus 0.0158 0.2897 1
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0225 0.4183 0.418
Trichomonas vaginalis tubulin, putative 0.016 0.2927 0.2927
Schistosoma mansoni tubulin subunit alpha 0.0134 0.2421 0.2421
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0064 0.1079 0.1014
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0033 0.0488 0.0488
Echinococcus granulosus mitogen activated protein kinase 3 0.0049 0.0797 0.0797
Echinococcus granulosus tubulin subunit TubB 0.0388 0.733 0.733
Echinococcus multilocularis peroxisome assembly protein 26 0.0388 0.733 0.733
Echinococcus granulosus voltage gated potassium channel 0.001 0.0042 0.0042
Brugia malayi Tubulin alpha-2 chain 0.0388 0.733 0.7323
Plasmodium vivax tubulin alpha chain, putative 0.0388 0.733 0.6477
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0049 0.0797 0.073
Plasmodium vivax tubulin epsilon chain, putative 0.0318 0.5975 0.469
Echinococcus granulosus tubulin gamma 1 chain 0.0318 0.5983 0.5983
Schistosoma mansoni hypothetical protein 0.0041 0.0628 0.0628
Echinococcus granulosus tubulin alpha chain 0.0388 0.733 0.733
Schistosoma mansoni retinoic acid receptor RXR 0.001 0.0031 0.0031
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0695 0.0695
Echinococcus granulosus smad 0.0009 0.0024 0.0024
Echinococcus granulosus transcription factor Dp 1 0.0037 0.0558 0.0558
Leishmania major alpha tubulin 0.0388 0.733 0.731
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0031 0.0007
Echinococcus granulosus tubulin epsilon chain 0.0318 0.5975 0.5975
Echinococcus multilocularis tubulin alpha chain 0.0388 0.733 0.733
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0015 0.0136 0.0136
Trichomonas vaginalis tubulin gamma chain, putative 0.0134 0.2421 0.2421
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0388 0.733 0.733
Brugia malayi hypothetical protein 0.0041 0.0628 0.0605
Entamoeba histolytica tubulin alpha-1 chain 0.0388 0.733 0.7151
Echinococcus multilocularis tubulin alpha 3 chain 0.0388 0.733 0.733
Brugia malayi ecdysteroid receptor 0.001 0.0031 0.0007
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.001 0.0031 0.0031
Echinococcus multilocularis tubulin gamma 1 chain 0.0318 0.5983 0.5983
Brugia malayi Tubulin alpha-2 chain 0.0388 0.733 0.7323
Trypanosoma brucei alpha tubulin 0.0388 0.733 0.731
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0049 0.0797 0.0472
Brugia malayi nuclear hormone receptor 0.001 0.0031 0.0007
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0292 0.5476 0.5317
Loa Loa (eye worm) cytochrome P450 family protein 0.0012 0.0072 0.0066
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0015 0.0136 0.0112
Schistosoma mansoni thyroid hormone receptor 0.001 0.0031 0.0031
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0031 0.0007
Echinococcus multilocularis tubulin alpha chain 0.0388 0.733 0.733
Brugia malayi Steroid receptor seven-up type 2 0.001 0.0031 0.0007
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0036 0.0533 0.0533
Loa Loa (eye worm) hypothetical protein 0.0169 0.3106 0.3102
Loa Loa (eye worm) hypothetical protein 0.0033 0.0477 0.0472
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0049 0.0797 0.073
Schistosoma mansoni transcription factor LCR-F1 0.0041 0.0628 0.0628
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0036 0.0533 0.051
Trypanosoma cruzi alpha tubulin, putative 0.0388 0.733 0.731
Echinococcus granulosus tubulin alpha chain 0.0388 0.733 0.733
Trypanosoma brucei alpha tubulin 0.0388 0.733 0.731
Schistosoma mansoni tubulin subunit alpha 0.0388 0.733 0.733
Trypanosoma cruzi zeta tubulin, putative 0.0405 0.765 0.7633

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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