TDR Targets

Basic information

Technical information

TDR Targets ID: 1202899
Name: 2-(3-chlorophenyl)sulfonyl-N-methyl-N-phenyla cetamide
MW: 323.795 | Formula: C15H14ClNO3S
H donors: 0 H acceptors: 3 LogP: 2.87 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: Clc1cccc(c1)S(=O)(=O)CC(=O)N(c1ccccc1)C
InChi: 1S/C15H14ClNO3S/c1-17(13-7-3-2-4-8-13)15(18)11-21(19,20)14-9-5-6-12(16)10-14/h2-10H,11H2,1H3
InChiKey: SLLOIXJZWAYOAL-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

2-(3-chlorophenyl)sulfonyl-N-methyl-N-phenyl-acetamide
2-(3-chlorophenyl)sulfonyl-N-methyl-N-phenyl-ethanamide
MLS000692070
SMR000333750
9H-394S
ZINC01402879
2-[(3-chlorophenyl)sulfonyl]-N-methyl-N-phenylacetamide

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Mus musculus	RAR-related orphan receptor gamma	Starlite/ChEMBL	No references
Homo sapiens	SMAD family member 2	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Loa Loa (eye worm)	MH2 domain-containing protein	Get druggable targets OG5_131716	All targets in OG5_131716
Brugia malayi	MH2 domain containing protein	Get druggable targets OG5_131716	All targets in OG5_131716
Loa Loa (eye worm)	transcription factor SMAD2	Get druggable targets OG5_131716	All targets in OG5_131716

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Brugia malayi	MH2 domain containing protein	SMAD family member 2	467 aa	405 aa	31.6 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0012	0.0503	0.0503
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0088	0.0088
Treponema pallidum	leucyl-tRNA synthetase	0.0023	0.1174	0.2274
Brugia malayi	Nuclear hormone receptor-like 1	0.0006	0.0132	0.0132
Schistosoma mansoni	RAR-like nuclear receptor	0.0012	0.0503	0.0825
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0059	0.3517	0.3517
Entamoeba histolytica	hypothetical protein	0.0038	0.2194	0.5637
Mycobacterium tuberculosis	Methionyl-tRNA synthetase MetS (MetRS) (methionine--tRNA ligase)	0.0059	0.3533	1
Entamoeba histolytica	hypothetical protein	0.0038	0.2194	0.5637
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0012	0.0503	0.0503
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0012	0.0503	0.0503
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0503	0.0503
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0038	0.2194	0.2194
Loa Loa (eye worm)	nuclear factor I	0.0005	0.0067	0.0067
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0028	0.1549	0.1549
Echinococcus granulosus	FTZ F1 alpha	0.0012	0.0503	0.0503
Echinococcus multilocularis	inositol polyphosphate 5 phosphatase OCRL 1	0.0012	0.0484	0.0484
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0088	0.0088
Brugia malayi	Nuclear hormone receptor-like 1	0.0012	0.0503	0.0503
Brugia malayi	hypothetical protein	0.0006	0.0088	0.0088
Onchocerca volvulus		0.0037	0.2077	0.222
Brugia malayi	MH2 domain containing protein	0.001	0.035	0.035
Schistosoma mansoni	cpg binding protein	0.003	0.1654	0.2711
Schistosoma mansoni	transcription factor LCR-F1	0.0038	0.2194	0.3597
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0088	0.0088
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0006	0.0088	0.0088
Schistosoma mansoni	smad1 5 8 and	0.001	0.035	0.0573
Brugia malayi	ecdysteroid receptor	0.0012	0.0503	0.0503
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0012	0.0503	0.0503
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0012	0.0503	0.0503
Echinococcus multilocularis	deoxyribonuclease 1 2	0.0012	0.0484	0.0484
Trichomonas vaginalis	type IV inositol 5-phosphatase, putative	0.0012	0.0484	0.1035
Schistosoma mansoni	nuclear receptor nhr-48	0.0006	0.0088	0.0144
Echinococcus granulosus	inositol monophosphatase 1	0.0039	0.226	0.226
Giardia lamblia	Methionyl-tRNA synthetase	0.0059	0.3533	1
Brugia malayi	nuclear receptor subfamily 1, group D, member 1, putative	0.0006	0.0088	0.0088
Echinococcus multilocularis	cpg binding protein	0.003	0.1654	0.1654
Onchocerca volvulus		0.0012	0.0484	0.0518
Brugia malayi	Endonuclease/Exonuclease/phosphatase family protein	0.0012	0.0484	0.0484
Echinococcus multilocularis	mothers against decapentaplegic 5	0.001	0.035	0.035
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0012	0.0503	0.0503
Echinococcus multilocularis	inositol monophosphatase 1	0.0039	0.226	0.226
Schistosoma mansoni	nuclear hormone receptor	0.0006	0.0088	0.0144
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0012	0.0503	0.0503
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0012	0.0503	0.0825
Echinococcus granulosus	traf and tnf receptor associated protein	0.0012	0.0484	0.0484
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0099	0.6099	0.6099
Echinococcus multilocularis	nuclear receptor nhr 48	0.0006	0.0088	0.0088
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0484	0.0484
Leishmania major	methionyl-tRNA synthetase, putative	0.0059	0.3533	1
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0012	0.0503	0.0503
Echinococcus granulosus	inositol polyphosphate 5 phosphatase OCRL 1	0.0012	0.0484	0.0484
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0012	0.0503	0.0503
Brugia malayi	hypothetical protein	0.015	0.9356	0.9356
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0099	0.6099	0.6099
Schistosoma mansoni	synaptojanin	0.0012	0.0484	0.0794
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0006	0.0088	0.0088
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0012	0.0503	0.0825
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0059	0.3517	0.993
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0039	0.226	0.6256
Onchocerca volvulus	Bile acid receptor homolog	0.0012	0.0503	0.0538
Schistosoma mansoni	Smad4	0.001	0.035	0.0573
Loa Loa (eye worm)	hypothetical protein	0.0023	0.1174	0.1174
Schistosoma mansoni	retinoic acid receptor RXR	0.0012	0.0503	0.0825
Brugia malayi	exodeoxyribonuclease III family protein	0.0059	0.3517	0.3517
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0006	0.0132	0.0132
Schistosoma mansoni	ap endonuclease	0.0059	0.3517	0.5766
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0006	0.0132	0.0217
Brugia malayi	MH1 domain containing protein	0.001	0.035	0.035
Schistosoma mansoni	cpg binding protein	0.003	0.1654	0.2711
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0012	0.0503	0.0503
Brugia malayi	hypothetical protein	0.0006	0.0088	0.0088
Entamoeba histolytica	hypothetical protein	0.0038	0.2194	0.5637
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0088	0.0088
Entamoeba histolytica	methionyl-tRNA synthetase, putative	0.0023	0.1174	0.2274
Entamoeba histolytica	exodeoxyribonuclease III, putative	0.0059	0.3517	1
Trichomonas vaginalis	ocrl type II inositol 5-phosphatase, putative	0.0012	0.0484	0.1035
Echinococcus granulosus	mixed lineage leukemia protein mll	0.0007	0.0172	0.0172
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0503	0.0503
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0099	0.6099	0.6099
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0012	0.0503	0.0503
Toxoplasma gondii	inositol(myo)-1(or 4)-monophosphatase 2, putative	0.0039	0.226	0.5823
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0059	0.3517	0.3517
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.006	0.3603	0.5907
Brugia malayi	Endonuclease/Exonuclease/phosphatase family protein	0.0012	0.0484	0.0484
Onchocerca volvulus		0.0012	0.0484	0.0518
Toxoplasma gondii	exonuclease III APE	0.0059	0.3517	0.9946
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0088	0.0088
Trypanosoma brucei	inositol-1(or 4)-monophosphatase 1, putative	0.0039	0.226	0.5823
Trypanosoma brucei	methionyl-tRNA synthetase, putative	0.0059	0.3533	1
Brugia malayi	hypothetical protein	0.0006	0.0132	0.0132
Onchocerca volvulus	Protein ultraspiracle homolog	0.0012	0.0503	0.0538
Echinococcus multilocularis	Smad4	0.001	0.035	0.035
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0012	0.0503	0.0503
Onchocerca volvulus		0.015	0.9356	1
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0132	0.0132
Brugia malayi	ecdysone receptor	0.0006	0.0088	0.0088
Plasmodium falciparum	methionine--tRNA ligase	0.0059	0.3533	1
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0039	0.226	0.5823
Wolbachia endosymbiont of Brugia malayi	fructose-1,6-bisphosphatase	0.0039	0.226	0.4602
Trichomonas vaginalis	sphingomyelinase C 2 precursor, putative	0.0012	0.0484	0.1035
Echinococcus granulosus	smad	0.001	0.035	0.035
Echinococcus granulosus	ecdysone induced protein 78C	0.0012	0.0503	0.0503
Loa Loa (eye worm)	MH1 domain-containing protein	0.001	0.035	0.035
Mycobacterium leprae	Probable methionyl-tRNA synthase MetS	0.0059	0.3533	1
Brugia malayi	nuclear receptor NHR-88	0.0006	0.0088	0.0088
Treponema pallidum	methionyl-tRNA synthetase	0.0023	0.1174	0.2274
Echinococcus granulosus	nuclear receptor nhr 48	0.0006	0.0088	0.0088
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0012	0.0503	0.0503
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0059	0.3517	0.9946
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0012	0.0503	0.0503
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0088	0.0088
Schistosoma mansoni	carbon catabolite repressor protein	0.0012	0.0484	0.0794
Schistosoma mansoni	cpg binding protein	0.0028	0.1549	0.254
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0088	0.0088
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0012	0.0503	0.0503
Loa Loa (eye worm)	tyrosyl-tRNA synthetase	0.0037	0.2077	0.2077
Echinococcus granulosus	methionine tRNA synthetase	0.0059	0.3533	0.3533
Mycobacterium ulcerans	methionyl-tRNA synthetase	0.0059	0.3533	1
Loa Loa (eye worm)	hypothetical protein	0.016	1	1
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.0059	0.3517	0.9946
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0088	0.0088
Echinococcus multilocularis	muscleblind protein	0.016	1	1
Trichomonas vaginalis	methionine-tRNA synthetase, putative	0.0059	0.3533	1
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	0.0059	0.3517	0.993
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0059	0.3517	0.3517
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0012	0.0503	0.0503
Schistosoma mansoni	nuclear hormone receptor superfamily protein-related	0.0006	0.0088	0.0144
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0007	0.0172	0.0172
Brugia malayi	Endonuclease/Exonuclease/phosphatase family protein	0.0012	0.0484	0.0484
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0009	0.0284	0.0284
Echinococcus granulosus	muscleblind protein	0.016	1	1
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0039	0.226	0.5823
Loa Loa (eye worm)	hypothetical protein	0.015	0.9356	0.9356
Echinococcus multilocularis	smad	0.001	0.035	0.035
Echinococcus multilocularis	muscleblind protein 1	0.016	1	1
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0012	0.0503	0.0503
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0099	0.6099	0.6099
Echinococcus multilocularis	TGF beta signal transducer SmadC	0.001	0.035	0.035
Loa Loa (eye worm)	transcription factor SMAD2	0.0144	0.9001	0.9001
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0067	0.0067
Schistosoma mansoni	leucyl-tRNA synthetase	0.0023	0.1174	0.1925
Brugia malayi	MH1 domain containing protein	0.001	0.035	0.035
Loa Loa (eye worm)	nuclear receptor NHR-67	0.0006	0.0088	0.0088
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	0.0006	0.0088	0.0088
Echinococcus granulosus	CCR4 NOT transcription complex subunit 6	0.0012	0.0484	0.0484
Loa Loa (eye worm)	Smad1	0.001	0.035	0.035
Brugia malayi	Endonuclease/Exonuclease/phosphatase family protein	0.0012	0.0484	0.0484
Schistosoma mansoni	thyroid hormone receptor	0.0012	0.0503	0.0825
Schistosoma mansoni	neutral sphingomyelinase	0.0012	0.0484	0.0794
Echinococcus granulosus	TGF beta signal transducer SmadC	0.001	0.035	0.035
Loa Loa (eye worm)	nuclear hormone receptor	0.0006	0.0088	0.0088
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0006	0.0088	0.0088
Schistosoma mansoni	cript-related	0.0012	0.0484	0.0794
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0006	0.0088	0.0088
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0006	0.0132	0.0217
Brugia malayi	protein ZK524.3	0.0023	0.1174	0.1174
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0503	0.0503
Echinococcus multilocularis	ecdysone induced protein 78C	0.0012	0.0503	0.0503
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0007	0.0172	0.0283
Brugia malayi	Nuclear hormone receptor-like 1	0.0006	0.0132	0.0132
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0009	0.0284	0.0284
Entamoeba histolytica	hypothetical protein	0.0038	0.2194	0.5637
Schistosoma mansoni	TGF-beta signal transducer Smad2	0.001	0.035	0.0573
Loa Loa (eye worm)	endonuclease/Exonuclease/phosphatase	0.0012	0.0484	0.0484
Echinococcus granulosus	cpg binding protein	0.003	0.1654	0.1654
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0006	0.0132	0.0132
Trichomonas vaginalis	carbon catabolite repressor protein, putative	0.0012	0.0484	0.1035
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0012	0.0503	0.0503
Echinococcus multilocularis	methionine tRNA synthetase	0.0059	0.3533	0.3533
Schistosoma mansoni	smad1 5 8 and	0.001	0.035	0.0573
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0012	0.0503	0.0503
Loa Loa (eye worm)	endonuclease/Exonuclease/phosphatase	0.0012	0.0484	0.0484
Echinococcus multilocularis	endonuclease exonuclease phosphatase	0.0012	0.0484	0.0484
Brugia malayi	MH2 domain containing protein	0.0144	0.9001	0.9001
Schistosoma mansoni	smad1 5 8 and	0.001	0.035	0.0573
Schistosoma mansoni	nuclear hormone receptor	0.0012	0.0503	0.0825
Echinococcus multilocularis	methionyl tRNA synthetase, cytoplasmic	0.0023	0.1174	0.1174
Echinococcus granulosus	neutral sphingomyelinase	0.0012	0.0484	0.0484
Brugia malayi	Nuclear hormone receptor E75	0.0006	0.0088	0.0088
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0503	0.0503
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0012	0.0503	0.0503
Schistosoma mansoni	methionine-tRNA synthetase	0.0059	0.3533	0.5793
Brugia malayi	methionyl-tRNA synthetase	0.0023	0.1174	0.1174
Brugia malayi	MH1 domain containing protein	0.0005	0.0067	0.0067
Onchocerca volvulus		0.0006	0.0088	0.0094
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0132	0.0132
Loa Loa (eye worm)	hypothetical protein	0.0023	0.1174	0.1174
Trypanosoma cruzi	methionyl-tRNA synthetase, putative	0.0059	0.3533	1
Trichomonas vaginalis	carbon catabolite repressor protein, putative	0.0012	0.0484	0.1035
Trichomonas vaginalis	skeletal muscle/kidney enriched inositol 5-phosphatase, putative	0.0012	0.0484	0.1035
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0099	0.6099	1
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0132	0.0132
Loa Loa (eye worm)	endonuclease/Exonuclease/phosphatase	0.0012	0.0484	0.0484
Brugia malayi	Endonuclease/Exonuclease/phosphatase family protein	0.0012	0.0484	0.0484
Loa Loa (eye worm)	hypothetical protein	0.0023	0.1174	0.1174
Schistosoma mansoni	nuclear receptor	0.0006	0.0088	0.0144
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0006	0.0088	0.0088
Brugia malayi	CXXC zinc finger family protein	0.0028	0.1549	0.1549
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0099	0.6099	0.6099
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	0.0059	0.3517	0.9946
Trichomonas vaginalis	ap endonuclease, putative	0.0059	0.3517	0.9952
Toxoplasma gondii	tRNA ligases class I (M) protein	0.0023	0.1174	0.2262
Schistosoma mansoni	smad	0.001	0.035	0.0573
Schistosoma mansoni	nuclear receptor	0.0006	0.0088	0.0144
Brugia malayi	nuclear hormone receptor	0.0006	0.0088	0.0088
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0054	0.3188	0.8867
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0099	0.6099	0.6099
Loa Loa (eye worm)	CCR4-NOT transcription complex subunit 6 family protein	0.0012	0.0484	0.0484
Schistosoma mansoni	nocturnin	0.0012	0.0484	0.0794
Brugia malayi	nuclear receptor RXR	0.0006	0.0132	0.0132
Schistosoma mansoni	hypothetical protein	0.0012	0.0484	0.0794
Plasmodium vivax	hypothetical protein, conserved	0.0023	0.1174	0.2262
Brugia malayi	hypothetical protein	0.0006	0.0132	0.0132
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.0059	0.3517	0.9946
Echinococcus granulosus	thyroid hormone receptor alpha	0.0006	0.0088	0.0088
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0503	0.0503
Brugia malayi	Endonuclease/Exonuclease/phosphatase family protein	0.0012	0.0484	0.0484
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0012	0.0503	0.0503
Brugia malayi	Smad1	0.001	0.035	0.035
Loa Loa (eye worm)	nuclear receptor nhr-7B	0.0006	0.0088	0.0088
Loa Loa (eye worm)	histone methyltransferase	0.0009	0.0284	0.0284
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0503	0.0503
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0484	0.0484
Schistosoma mansoni	nuclear hormone receptor	0.0006	0.0088	0.0144
Brugia malayi	MH2 domain containing protein	0.001	0.035	0.035
Entamoeba histolytica	myo-inositol monophosphatase, putative	0.0039	0.226	0.5855
Schistosoma mansoni	methionine-tRNA synthetase	0.0023	0.1174	0.1925
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0012	0.0503	0.0503
Onchocerca volvulus	Putative neutral sphingomyelinase	0.0012	0.0484	0.0518
Brugia malayi	Inositol-1	0.0039	0.226	0.226
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0088	0.0088
Trichomonas vaginalis	carbon catabolite repressor protein, putative	0.0012	0.0484	0.1035
Echinococcus granulosus	mothers against decapentaplegic 5	0.001	0.035	0.035
Brugia malayi	methionyl-tRNA synthetase	0.0059	0.3533	0.3533
Loa Loa (eye worm)	methionyl-tRNA synthetase	0.0059	0.3533	0.3533
Brugia malayi	Endonuclease/Exonuclease/phosphatase family protein	0.0012	0.0484	0.0484
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0132	0.0132
Trichomonas vaginalis	Phospholipase C precursor, putative	0.0012	0.0484	0.1035
Plasmodium vivax	methionine--tRNA ligase, putative	0.0023	0.1174	0.2262
Plasmodium falciparum	methionine--tRNA ligase, putative	0.0023	0.1174	0.2262
Wolbachia endosymbiont of Brugia malayi	methionyl-tRNA synthetase	0.0059	0.3533	1
Brugia malayi	Nuclear hormone receptor E75	0.0006	0.0088	0.0088
Echinococcus multilocularis	FTZ F1 alpha	0.0012	0.0503	0.0503
Chlamydia trachomatis	methionine--tRNA ligase	0.0023	0.1174	0.5
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0088	0.0088
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0007	0.0172	0.0172
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0012	0.0503	0.0503
Chlamydia trachomatis	leucine--tRNA ligase	0.0023	0.1174	0.5
Brugia malayi	steroid hormone receptor	0.0012	0.0503	0.0503
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0059	0.3517	0.9946
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0012	0.0503	0.0825
Loa Loa (eye worm)	endonuclease/Exonuclease/phosphatase	0.0012	0.0484	0.0484
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0012	0.0503	0.0503
Schistosoma mansoni	ocrl type II inositol 5-phosphatase	0.0012	0.0484	0.0794
Brugia malayi	hypothetical protein	0.0038	0.2194	0.2194
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0012	0.0503	0.0538
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0039	0.226	0.6256
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0012	0.0503	0.0503
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0503	0.0503
Brugia malayi	MH1 domain containing protein	0.0005	0.0067	0.0067
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.0059	0.3517	0.9946
Schistosoma mansoni	ap endonuclease	0.0059	0.3517	0.5766
Schistosoma mansoni	inositol monophosphatase	0.0039	0.226	0.3705
Brugia malayi	conserved hypotetical protein	0.0006	0.0088	0.0088
Schistosoma mansoni	thyroid hormone receptor	0.0012	0.0503	0.0825
Trichomonas vaginalis	ap endonuclease, putative	0.0059	0.3517	0.9952
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0088	0.0088
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0012	0.0503	0.0825
Brugia malayi	F/Y-rich N-terminus family protein	0.0009	0.0277	0.0277
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0012	0.0503	0.0503
Loa Loa (eye worm)	hypothetical protein	0.016	1	1
Loa Loa (eye worm)	MH2 domain-containing protein	0.001	0.035	0.035
Onchocerca volvulus		0.0006	0.0088	0.0094
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0006	0.0088	0.0088
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0484	0.0484
Loa Loa (eye worm)	steroid hormone receptor	0.0012	0.0503	0.0503
Echinococcus granulosus	endonuclease exonuclease phosphatase	0.0012	0.0484	0.0484
Echinococcus multilocularis	neutral sphingomyelinase	0.0012	0.0484	0.0484
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0012	0.0503	0.0503
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0088	0.0088
Schistosoma mansoni	inositol monophosphatase	0.0039	0.226	0.3705
Brugia malayi	nuclear hormone receptor	0.0012	0.0503	0.0503
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0012	0.0503	0.0825
Onchocerca volvulus		0.0012	0.0503	0.0538
Echinococcus multilocularis	traf and tnf receptor associated protein	0.0012	0.0484	0.0484
Loa Loa (eye worm)	endonuclease/Exonuclease/phosphatase	0.0012	0.0484	0.0484
Trichomonas vaginalis	inositol monophosphatase, putative	0.0039	0.226	0.6256
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0012	0.0503	0.0503
Loa Loa (eye worm)	inositol-1	0.0039	0.226	0.226
Schistosoma mansoni	synaptojanin	0.0012	0.0484	0.0794
Echinococcus multilocularis	CCR4 NOT transcription complex subunit 6	0.0012	0.0484	0.0484
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0132	0.0132
Schistosoma mansoni	hypothetical protein	0.0038	0.2194	0.3597
Echinococcus granulosus	methionyl tRNA synthetase cytoplasmic	0.0023	0.1174	0.1174
Schistosoma mansoni	coup transcription factor	0.0012	0.0503	0.0825
Echinococcus multilocularis	leucyl tRNA synthetase	0.0023	0.1174	0.1174
Mycobacterium ulcerans	extragenic suppressor protein SuhB	0.0039	0.226	0.4602
Brugia malayi	nuclear hormone receptor family member nhr-6	0.0006	0.0088	0.0088
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0012	0.0503	0.0503
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0006	0.0088	0.0094
Toxoplasma gondii	methionyl-tRNA synthetase	0.0059	0.3533	1
Schistosoma mansoni	zinc finger protein	0.0006	0.0088	0.0144
Giardia lamblia	Leucyl-tRNA synthetase	0.0023	0.1174	0.2262
Leishmania major	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0039	0.226	0.5823
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0012	0.0503	0.0825
Echinococcus granulosus	nuclear receptor subfamily 4 group A	0.0006	0.0088	0.0088
Echinococcus granulosus	Smad4	0.001	0.035	0.035
Mycobacterium tuberculosis	Inositol-1-monophosphatase SuhB	0.0035	0.1993	0.4949
Echinococcus multilocularis	synaptojanin 1	0.0012	0.0484	0.0484
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0038	0.2194	0.2194
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0059	0.3517	0.9946
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0503	0.0503
Leishmania major	leucyl-tRNA synthetase, putative	0.0023	0.1174	0.2262
Brugia malayi	nuclear hormone receptor family member odr-7	0.0006	0.0088	0.0088
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0006	0.0132	0.0132
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0012	0.0503	0.0503
Trichomonas vaginalis	type II inositol 5-phosphatase, putative	0.0012	0.0484	0.1035
Brugia malayi	nuclear receptor NHR-67	0.0006	0.0088	0.0088
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0006	0.0088	0.0094
Brugia malayi	Endonuclease/Exonuclease/phosphatase family protein	0.0012	0.0484	0.0484
Brugia malayi	tailless protein	0.0006	0.0088	0.0088
Echinococcus multilocularis	nuclear receptor subfamily 4 group A	0.0006	0.0088	0.0088
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0012	0.0503	0.0503
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0088	0.0088
Onchocerca volvulus		0.0028	0.1549	0.1656
Brugia malayi	nuclear receptor RXR	0.0006	0.0088	0.0088
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0012	0.0503	0.0825
Plasmodium vivax	methionine--tRNA ligase, putative	0.0059	0.3533	1
Brugia malayi	orphan nuclear receptor NR2E1	0.0006	0.0088	0.0088
Brugia malayi	Steroid receptor seven-up type 2	0.0012	0.0503	0.0503
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0059	0.3517	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0012	0.0503	0.0503
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0484	0.0484
Brugia malayi	photoreceptor-specific nuclear receptor	0.0012	0.0503	0.0503
Brugia malayi	Endonuclease/Exonuclease/phosphatase family protein	0.0012	0.0484	0.0484
Brugia malayi	CCR4	0.0012	0.0484	0.0484
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.0059	0.3517	0.9946
Schistosoma mansoni	hepatocyte nuclear factor 4-alpha (hnf-4-alpha)	0.0006	0.0088	0.0144
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0012	0.0503	0.0503
Loa Loa (eye worm)	DR-78	0.0006	0.0088	0.0088
Echinococcus multilocularis	mixed lineage leukemia protein mll	0.0007	0.0172	0.0172
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0099	0.6099	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0099	0.6099	1
Loa Loa (eye worm)	MH2 domain-containing protein	0.0144	0.9001	0.9001
Echinococcus granulosus	synaptojanin 1	0.0012	0.0484	0.0484
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0012	0.0503	0.0503
Brugia malayi	nuclear receptor NHR-88	0.0012	0.0503	0.0503

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	0.7375 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	= 11.2202 um	PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	15.8489 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860]	ChEMBL.	No reference
Potency (functional)	89.1251 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Plasmodium falciparum	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1299790

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1202899