Detailed information for compound 1211074

Basic information

Technical information
  • TDR Targets ID: 1211074
  • Name: [3-[(4-hydroxyphenyl)amino]-3-oxopropyl]-dime thylsulfanium
  • MW: 226.315 | Formula: C11H16NO2S+
  • H donors: 2 H acceptors: 2 LogP: 1.34 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(Nc1ccc(cc1)O)CC[S+](C)C
  • InChi: 1S/C11H15NO2S/c1-15(2)8-7-11(14)12-9-3-5-10(13)6-4-9/h3-6H,7-8H2,1-2H3,(H-,12,13,14)/p+1
  • InChiKey: WMODNNJVPJEQFP-UHFFFAOYSA-O  


Substructure search Similarity search

Network

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Synonyms

  • [3-[(4-hydroxyphenyl)amino]-3-oxo-propyl]-dimethyl-sulfonium
  • [3-[(4-hydroxyphenyl)amino]-3-oxopropyl]-dimethylsulfonium
  • [3-[(4-hydroxyphenyl)amino]-3-keto-propyl]-dimethyl-sulfonium
  • [3-[(4-hydroxyphenyl)amino]-3-oxo-propyl]-dimethyl-sulfanium

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus Eukaryotic initiation factor 4A homolog 0.0199 0.552 1
Trypanosoma cruzi hydroxyacylglutathione hydrolase, putative 0.0051 0.0872 0.1487
Schistosoma mansoni lipoxygenase 0.0117 0.2949 0.3023
Echinococcus granulosus thioredoxin glutathione reductase 0.0038 0.0457 0.0457
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0283 0.8175 0.8175
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0085 0.194 0.2952
Entamoeba histolytica metallo-beta-lactamase family protein 0.0051 0.0872 0.1487
Echinococcus granulosus eukaryotic initiation factor 4A III 0.0199 0.552 0.552
Echinococcus granulosus eukaryotic initiation factor 4A 0.0199 0.552 0.552
Mycobacterium tuberculosis Possible hydrolase 0.0051 0.0872 0.0848
Echinococcus multilocularis m phase inducer phosphatase(cdc25) 0.011 0.274 0.274
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0283 0.8175 0.8334
Trichomonas vaginalis m-phase inducer phosphatase, putative 0.011 0.274 0.3327
Schistosoma mansoni hypothetical protein 0.0034 0.0334 0.0342
Plasmodium falciparum ataxin-2 like protein, putative 0.0049 0.0812 0.0731
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0036 0.0389 0.0604
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0071 0.1511 0.1316
Plasmodium vivax RNA helicase-1, putative 0.0199 0.552 1
Entamoeba histolytica rodhanase-like domain containing protein 0.011 0.274 0.4908
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0094 0.2238 0.3538
Trichomonas vaginalis mitotic inducer phosphatase CDC25, putative 0.011 0.274 0.3327
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.0199 0.552 0.6779
Schistosoma mansoni tar DNA-binding protein 0.0334 0.9757 1
Trichomonas vaginalis glucosylceramidase, putative 0.0185 0.5073 0.6225
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0052 0.091 0.0684
Chlamydia trachomatis ribonuclease Z 0.0051 0.0872 0.5
Trichomonas vaginalis beta lactamase domain, putative 0.0051 0.0872 0.1008
Onchocerca volvulus Glucosylceramidase homolog 0.0185 0.5073 0.9151
Trypanosoma brucei PAB1-binding protein , putative 0.0049 0.0812 0.1378
Trypanosoma cruzi glyoxalase II 0.0051 0.0872 0.1487
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0056 0.1029 0.1246
Echinococcus multilocularis GPCR, family 2 0.0034 0.0334 0.0334
Brugia malayi Chain A, Human Glyoxalase Ii With Cacodylate And Acetate Ions Present In The Active Site. 0.0051 0.0872 0.0837
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0065 0.1313 0.1313
Leishmania major hypothetical protein, conserved 0.0049 0.0812 0.0824
Leishmania major cleavage and polyadenylation specificity factor, putative 0.0051 0.0872 0.094
Brugia malayi TAR-binding protein 0.0334 0.9757 1
Trichomonas vaginalis chromobox protein, putative 0.0043 0.063 0.0708
Loa Loa (eye worm) hypothetical protein 0.0146 0.3848 0.3777
Toxoplasma gondii metallo-beta-lactamase domain-containing protein 0.0051 0.0872 0.1487
Brugia malayi Latrophilin receptor protein 2 0.0034 0.0334 0.0282
Schistosoma mansoni tar DNA-binding protein 0.0334 0.9757 1
Trichomonas vaginalis maltase-glucoamylase, putative 0.0036 0.0389 0.0409
Echinococcus multilocularis tar DNA binding protein 0.0334 0.9757 0.9757
Trichomonas vaginalis glutaminase, putative 0.0269 0.7727 0.9519
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.0199 0.552 0.6779
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0036 0.0389 0.0135
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0036 0.0389 0.0604
Entamoeba histolytica DEAD/DEAH box helicase, putative 0.0199 0.552 1
Echinococcus multilocularis metallo beta lactamase domain containing protein 0.0051 0.0872 0.0872
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0107 0.2629 0.2494
Echinococcus multilocularis muscleblind protein 0.0146 0.3848 0.3848
Trichomonas vaginalis chromobox protein, putative 0.0072 0.1524 0.1818
Brugia malayi Muscleblind-like protein 0.0146 0.3848 0.3906
Trichomonas vaginalis m-phase inducer phosphatase, putative 0.011 0.274 0.3327
Trypanosoma cruzi Eukaryotic initiation factor 4A-1 0.0199 0.552 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0389 0.0409
Schistosoma mansoni alpha-glucosidase 0.0138 0.3609 0.3699
Loa Loa (eye worm) hydroxyacylglutathione hydrolase 0.0051 0.0872 0.0643
Brugia malayi hypothetical protein 0.0051 0.0872 0.0837
Plasmodium vivax ataxin-2 like protein, putative 0.0049 0.0812 0.0731
Echinococcus granulosus muscleblind protein 0.0146 0.3848 0.3848
Echinococcus granulosus ETHE1 protein 0.0051 0.0872 0.0872
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0034 0.0334 0.0282
Brugia malayi glutathione reductase 0.0037 0.0441 0.0393
Echinococcus multilocularis zinc phosphodiesterase 0.0051 0.0872 0.0872
Schistosoma mansoni alpha-glucosidase 0.0138 0.3609 0.3699
Brugia malayi eukaryotic initiation factor 4A 0.0199 0.552 0.5631
Entamoeba histolytica alkyl sulfatase, putative 0.0051 0.0872 0.1487
Loa Loa (eye worm) hypothetical protein 0.005 0.0841 0.0611
Loa Loa (eye worm) latrophilin receptor protein 2 0.0034 0.0334 0.0076
Entamoeba histolytica metallo-beta-lactamase family protein 0.0051 0.0872 0.1487
Loa Loa (eye worm) metallo-beta-lactamase superfamily protein 0.0051 0.0872 0.0643
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0334 0.9757 1
Brugia malayi glutaminase DH11.1 0.0269 0.7727 0.7907
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0036 0.0389 0.0604
Trypanosoma cruzi metallo-beta-lactamase-like protein, putative 0.0051 0.0872 0.1487
Loa Loa (eye worm) hypothetical protein 0.0039 0.0512 0.0264
Entamoeba histolytica metallo-beta-lactamase superfamily protein 0.0051 0.0872 0.1487
Trichomonas vaginalis conserved hypothetical protein 0.0051 0.0872 0.1008
Mycobacterium ulcerans glutaminase 0.0269 0.7727 1
Leishmania major eukaryotic initiation factor 4a, putative 0.0199 0.552 1
Echinococcus granulosus metallo beta lactamase domain containing protein 0.0051 0.0872 0.0872
Toxoplasma gondii thioredoxin reductase 0.0037 0.0441 0.0699
Onchocerca volvulus Hydroxyacylglutathione hydrolase, mitochondrial homolog 0.0051 0.0872 0.1161
Plasmodium vivax hydroxyacyl glutathione hydrolase, putative 0.0051 0.0872 0.0848
Trichomonas vaginalis cdc25c, putative 0.011 0.274 0.3327
Loa Loa (eye worm) hypothetical protein 0.0049 0.0812 0.058
Onchocerca volvulus 0.0051 0.0872 0.1161
Loa Loa (eye worm) hypothetical protein 0.0102 0.2469 0.2325
Trichomonas vaginalis conserved hypothetical protein 0.0051 0.0872 0.1008
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0034 0.0334 0.0334
Trichomonas vaginalis glucosylceramidase, putative 0.0281 0.8114 1
Loa Loa (eye worm) hypothetical protein 0.0042 0.0588 0.0345
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0085 0.194 0.2952
Loa Loa (eye worm) thioredoxin reductase 0.0037 0.0441 0.019
Schistosoma mansoni ets-related 0.0216 0.6072 0.6223
Echinococcus granulosus tar DNA binding protein 0.0334 0.9757 0.9757
Onchocerca volvulus 0.0156 0.4173 0.7439
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0389 0.0604
Loa Loa (eye worm) hypothetical protein 0.0051 0.0872 0.0643
Entamoeba histolytica metallo-beta-lactamase superfamily protein 0.0051 0.0872 0.1487
Entamoeba histolytica alkyl sulfatase, putative 0.0051 0.0872 0.1487
Trypanosoma brucei Eukaryotic initiation factor 4A-1 0.0199 0.552 1
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0025 0.006 0.0061
Echinococcus multilocularis ETHE1 protein 0.0051 0.0872 0.0872
Leishmania major eukaryotic initiation factor 4a, putative 0.0199 0.552 1
Echinococcus multilocularis tumor protein p63 0.0341 1 1
Echinococcus granulosus GA binding protein alpha chain 0.0071 0.1511 0.1511
Trichomonas vaginalis beta lactamase domain, putative 0.0051 0.0872 0.1008
Trichomonas vaginalis glucosylceramidase, putative 0.0185 0.5073 0.6225
Mycobacterium tuberculosis Probable oxidoreductase 0.0094 0.2238 0.3538
Trichomonas vaginalis cdc25b, putative 0.011 0.274 0.3327
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0056 0.1029 0.1029
Schistosoma mansoni zinc phosphodiesterase 0.0051 0.0872 0.0893
Loa Loa (eye worm) hypothetical protein 0.0073 0.1558 0.1366
Schistosoma mansoni hydroxyacylglutathione hydrolase (Glyoxalase II) (Glx II) 0.0051 0.0872 0.0893
Trypanosoma cruzi glyoxalase II 0.0051 0.0872 0.1487
Trypanosoma cruzi metallo-beta-lactamase superfamily, putative 0.0051 0.0872 0.1487
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0085 0.194 0.2952
Trypanosoma cruzi trypanothione reductase, putative 0.0037 0.0441 0.0699
Echinococcus multilocularis hydroxyacylglutathione hydrolase 0.0051 0.0872 0.0872
Trypanosoma brucei cleavage and polyadenylation specificity factor subunit, putative 0.0051 0.0872 0.1487
Onchocerca volvulus 0.011 0.274 0.4713
Entamoeba histolytica type A flavoprotein, putative 0.0051 0.0872 0.1487
Onchocerca volvulus 0.011 0.274 0.4713
Trichomonas vaginalis glucosylceramidase, putative 0.0281 0.8114 1
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0094 0.2238 0.3538
Leishmania major hydroxyacylglutathione hydrolase, putative,glyoxalase II, putative 0.0051 0.0872 0.094
Echinococcus granulosus geminin 0.0174 0.4751 0.4751
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0065 0.1313 0.1346
Brugia malayi MH2 domain containing protein 0.0135 0.3514 0.3562
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0061 0.1202 0.1202
Mycobacterium tuberculosis Conserved hypothetical protein 0.0051 0.0872 0.0848
Loa Loa (eye worm) hypothetical protein 0.0146 0.3848 0.3777
Brugia malayi hypothetical protein 0.0156 0.4173 0.4242
Brugia malayi RNA binding protein 0.0334 0.9757 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0283 0.8175 0.8369
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0251 0.7167 0.7273
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0283 0.8175 0.8379
Schistosoma mansoni m-phase inducer phosphatase(cdc25) 0.011 0.274 0.2808
Onchocerca volvulus 0.0093 0.2186 0.366
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0389 0.0409
Entamoeba histolytica rodhanase-like domain containing protein 0.011 0.274 0.4908
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0056 0.1029 0.0229
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0056 0.1029 0.1054
Brugia malayi Fli-1 protein 0.0216 0.6072 0.62
Plasmodium falciparum ataxin-2 like protein, putative 0.0049 0.0812 0.0731
Trichomonas vaginalis beta lactamase domain, putative 0.0051 0.0872 0.1008
Schistosoma mansoni hypothetical protein 0.0051 0.0872 0.0893
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0389 0.0409
Trypanosoma cruzi PAB1-binding protein , putative 0.0049 0.0812 0.1378
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0056 0.1029 0.0229
Brugia malayi Rhodanese-like domain containing protein 0.011 0.274 0.2764
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0061 0.1202 0.1202
Schistosoma mansoni zinc phosphodiesterase 0.0051 0.0872 0.0893
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.1313 0.2295
Trypanosoma cruzi glyoxalase II 0.0051 0.0872 0.1487
Echinococcus granulosus serine protein kinase ATM 0.0025 0.006 0.006
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.1313 0.2295
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0389 0.0604
Schistosoma mansoni hypothetical protein 0.0051 0.0872 0.0893
Mycobacterium tuberculosis Possible hydrolase 0.0051 0.0872 0.0848
Mycobacterium tuberculosis Conserved hypothetical protein 0.0051 0.0872 0.0848
Echinococcus granulosus chromobox protein 1 0.0072 0.1524 0.1524
Echinococcus multilocularis muscleblind protein 1 0.0146 0.3848 0.3848
Echinococcus multilocularis transcription factor Dp 1 0.0038 0.0453 0.0453
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0283 0.8175 0.8175
Echinococcus multilocularis eukaryotic initiation factor 4A III 0.0199 0.552 0.552
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0065 0.1313 0.2295
Trichomonas vaginalis conserved hypothetical protein 0.0051 0.0872 0.1008
Mycobacterium tuberculosis Conserved protein 0.0051 0.0872 0.0848
Trichomonas vaginalis apoptosis inducing factor, putative 0.0054 0.0979 0.1142
Trichomonas vaginalis glucosylceramidase, putative 0.0185 0.5073 0.6225
Mycobacterium tuberculosis Probable reductase 0.0085 0.194 0.2952
Loa Loa (eye worm) fli-1 protein 0.0216 0.6072 0.612
Trichomonas vaginalis glucosylceramidase, putative 0.0185 0.5073 0.6225
Trypanosoma brucei metallo-beta-lactamase-like protein, putative 0.0051 0.0872 0.1487
Echinococcus granulosus hydroxyacylglutathione hydrolase 0.0051 0.0872 0.0872
Plasmodium vivax unspecified product 0.0051 0.0872 0.0848
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0043 0.063 0.0701
Loa Loa (eye worm) heterochromatin protein 1 0.0072 0.1524 0.133
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0056 0.1029 0.1157
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0056 0.1029 0.1029
Brugia malayi chromobox protein homolog 3 0.004 0.0534 0.0489
Echinococcus multilocularis GA binding protein alpha chain 0.0071 0.1511 0.1511
Echinococcus granulosus metallo beta lactamase domain containing protein 0.0051 0.0872 0.0872
Trichomonas vaginalis conserved hypothetical protein 0.0051 0.0872 0.1008
Schistosoma mansoni alpha glucosidase 0.0036 0.0389 0.0399
Trypanosoma brucei glyoxalase II 0.0051 0.0872 0.1487
Trichomonas vaginalis mitotic inducer phosphatase CDC25, putative 0.011 0.274 0.3327
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0054 0.0979 0.1142
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0065 0.1313 0.1292
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.016 0.4311 0.4265
Mycobacterium tuberculosis Conserved hypothetical protein 0.0051 0.0872 0.0848
Echinococcus granulosus GPCR family 2 0.0034 0.0334 0.0334
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0037 0.0433 0.0433
Leishmania major hypothetical protein, conserved 0.0051 0.0872 0.094
Onchocerca volvulus 0.011 0.274 0.4713
Trypanosoma brucei trypanothione reductase 0.0037 0.0441 0.0699
Brugia malayi Calcitonin receptor-like protein seb-1 0.0107 0.2629 0.265
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0283 0.8175 0.8379
Loa Loa (eye worm) hypothetical protein 0.0107 0.2629 0.2494
Echinococcus multilocularis lysosomal alpha glucosidase 0.016 0.4311 0.4311
Trichomonas vaginalis glucosylceramidase, putative 0.0185 0.5073 0.6225
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0117 0.2949 0.2949
Loa Loa (eye worm) glutaminase 0.0269 0.7727 0.7863
Trichomonas vaginalis mitotic inducer phosphatase CDC25, putative 0.011 0.274 0.3327
Wolbachia endosymbiont of Brugia malayi metallo-beta-lactamase superfamily hydrolase 0.0051 0.0872 0.5
Loa Loa (eye worm) hypothetical protein 0.004 0.0534 0.0287
Schistosoma mansoni hypothetical protein 0.0174 0.4751 0.487
Schistosoma mansoni hypothetical protein 0.0034 0.0334 0.0342
Trichomonas vaginalis glucosylceramidase, putative 0.0185 0.5073 0.6225
Echinococcus granulosus zinc phosphodiesterase 0.0051 0.0872 0.0872
Entamoeba histolytica hypothetical protein, conserved 0.0051 0.0872 0.1487
Onchocerca volvulus 0.011 0.274 0.4713
Schistosoma mansoni glutaminase 0.0269 0.7727 0.792
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0034 0.0334 0.0334
Schistosoma mansoni tar DNA-binding protein 0.0334 0.9757 1
Plasmodium falciparum eukaryotic initiation factor 4A 0.0199 0.552 1
Loa Loa (eye worm) hypothetical protein 0.0073 0.1567 0.1375
Brugia malayi Glycosyl hydrolases family 31 protein 0.016 0.4311 0.4384
Mycobacterium tuberculosis Conserved protein 0.0051 0.0872 0.0848
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0065 0.1313 0.18
Leishmania major metallo-beta-lactamase family-like protein 0.0051 0.0872 0.094
Echinococcus granulosus neutral alpha glucosidase AB 0.0036 0.0389 0.0389
Loa Loa (eye worm) hypothetical protein 0.011 0.274 0.261
Schistosoma mansoni DEAD box ATP-dependent RNA helicase 0.0199 0.552 0.5658
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0534 0.0589
Echinococcus granulosus m phase inducer phosphatasecdc25 0.011 0.274 0.274
Trichomonas vaginalis sucrase-isomaltase, putative 0.0036 0.0389 0.0409
Trichomonas vaginalis beta lactamase domain, putative 0.0051 0.0872 0.1008
Trypanosoma cruzi Eukaryotic initiation factor 4A-1 0.0199 0.552 1
Echinococcus multilocularis lysosomal alpha glucosidase 0.016 0.4311 0.4311
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0534 0.0589
Echinococcus granulosus lysosomal alpha glucosidase 0.016 0.4311 0.4311
Loa Loa (eye worm) hypothetical protein 0.0044 0.065 0.041
Trypanosoma cruzi PAB1-binding protein , putative 0.0049 0.0812 0.1378
Schistosoma mansoni hypothetical protein 0.0051 0.0872 0.0893
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.0199 0.552 0.6779
Brugia malayi Bromodomain containing protein 0.0077 0.1696 0.1688
Treponema pallidum ATP-dependent RNA helicase 0.0199 0.552 1
Loa Loa (eye worm) transcription factor SMAD2 0.0135 0.3514 0.3426
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.1313 0.2295
Loa Loa (eye worm) glutathione reductase 0.0037 0.0441 0.019
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0165 0.0131
Schistosoma mansoni bromodomain containing protein 0.0065 0.1317 0.135
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0065 0.1313 0.1313
Echinococcus granulosus chromobox protein 1 0.0072 0.1524 0.1524
Brugia malayi hypothetical protein 0.0049 0.0812 0.0776
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0281 0.8114 0.827
Loa Loa (eye worm) MH2 domain-containing protein 0.0135 0.3514 0.3426
Trichomonas vaginalis A-type flavoprotein 0.0051 0.0872 0.1008
Brugia malayi Thioredoxin reductase 0.0037 0.0441 0.0393
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0107 0.2629 0.265
Schistosoma mansoni chromobox protein 0.0072 0.1524 0.1562
Brugia malayi Glycosyl hydrolases family 31 protein 0.0036 0.0389 0.034
Onchocerca volvulus 0.0051 0.0872 0.1161
Brugia malayi RNA recognition motif domain containing protein 0.0334 0.9757 1
Schistosoma mansoni hypothetical protein 0.0174 0.4751 0.487
Echinococcus multilocularis neutral alpha glucosidase AB 0.0036 0.0389 0.0389
Loa Loa (eye worm) hypothetical protein 0.0061 0.1186 0.0974
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0389 0.0409
Trypanosoma cruzi metallo-beta-lactamase-like protein, putative 0.0051 0.0872 0.1487
Trichomonas vaginalis cdc25b, putative 0.011 0.274 0.3327
Trichomonas vaginalis conserved hypothetical protein 0.0051 0.0872 0.1008
Trichomonas vaginalis glucosylceramidase, putative 0.0281 0.8114 1
Toxoplasma gondii hydroxyacylglutathione hydrolase 0.0051 0.0872 0.1487
Brugia malayi Ets-domain containing protein 0.0071 0.1511 0.1497
Brugia malayi Ets-domain containing protein 0.0071 0.1511 0.1497
Mycobacterium tuberculosis Probable dehydrogenase 0.0085 0.194 0.2952
Schistosoma mansoni tar DNA-binding protein 0.0334 0.9757 1
Brugia malayi Bromodomain containing protein 0.0039 0.051 0.0464
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0389 0.0409
Loa Loa (eye worm) hydroxyacylglutathione hydrolase cytoplasmic 0.0051 0.0872 0.0643
Trypanosoma cruzi hydroxyacylglutathione hydrolase, putative 0.0051 0.0872 0.1487
Trichomonas vaginalis glucosylceramidase, putative 0.0195 0.5386 0.6612
Loa Loa (eye worm) hypothetical protein 0.0051 0.0872 0.0643
Loa Loa (eye worm) hypothetical protein 0.011 0.274 0.261
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0283 0.8175 0.8379
Brugia malayi Rhodanese-like domain containing protein 0.011 0.274 0.2764
Onchocerca volvulus 0.005 0.0841 0.1103
Loa Loa (eye worm) hypothetical protein 0.0051 0.0872 0.0643
Trichomonas vaginalis glucosylceramidase, putative 0.0281 0.8114 1
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0085 0.194 0.2952
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0065 0.1313 0.1108
Mycobacterium tuberculosis Beta lactamase like protein 0.0051 0.0872 0.0848
Toxoplasma gondii eukaryotic initiation factor-4A, putative 0.0199 0.552 1
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0165 0.0131
Trichomonas vaginalis chromobox protein, putative 0.0043 0.063 0.0708
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0117 0.2949 0.2949
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0283 0.8175 0.8175
Brugia malayi follicle stimulating hormone receptor 0.0251 0.7167 0.7329
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0034 0.0334 0.0334
Echinococcus granulosus transcription factor Dp 1 0.0038 0.0453 0.0453
Echinococcus multilocularis thioredoxin glutathione reductase 0.0038 0.0457 0.0457
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0056 0.1029 0.0999
Brugia malayi Heterochromatin protein 1 0.0072 0.1524 0.151
Schistosoma mansoni hypothetical protein 0.0034 0.0334 0.0342
Trypanosoma cruzi metallo-beta-lactamase superfamily, putative 0.0051 0.0872 0.1487
Brugia malayi hypothetical protein 0.0032 0.0266 0.0213
Leishmania major trypanothione reductase 0.0037 0.0441 0.0101
Schistosoma mansoni hypothetical protein 0.0034 0.0334 0.0342
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0034 0.0334 0.0334
Brugia malayi metallo-beta-lactamase superfamily protein 0.0051 0.0872 0.0837
Onchocerca volvulus Heterochromatin protein 1 homolog 0.004 0.0534 0.0519
Schistosoma mansoni tar DNA-binding protein 0.0334 0.9757 1
Loa Loa (eye worm) RNA binding protein 0.0334 0.9757 1
Brugia malayi metallo-beta-lactamase superfamily protein 0.0051 0.0872 0.0837
Loa Loa (eye worm) hypothetical protein 0.0102 0.2469 0.2325
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0036 0.0389 0.0409
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0094 0.2238 1
Loa Loa (eye worm) hypothetical protein 0.0034 0.0334 0.0076
Loa Loa (eye worm) TAR-binding protein 0.0334 0.9757 1
Echinococcus multilocularis eukaryotic initiation factor 4A 0.0199 0.552 0.552
Brugia malayi PHD-finger family protein 0.0026 0.0077 0.0017
Entamoeba histolytica rodhanase-like domain containing protein 0.011 0.274 0.4908
Trypanosoma brucei glucosidase, putative 0.0036 0.0389 0.0604
Echinococcus multilocularis chromobox protein 1 0.0072 0.1524 0.1524
Trichomonas vaginalis beta lactamase domain, putative 0.0051 0.0872 0.1008
Loa Loa (eye worm) glutaminase 2 0.0269 0.7727 0.7863
Loa Loa (eye worm) hypothetical protein 0.0199 0.552 0.5538
Leishmania major metallo-beta-lactamase family protein-like protein 0.0051 0.0872 0.094
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0037 0.0433 0.0433
Schistosoma mansoni lipoxygenase 0.0082 0.1842 0.1888
Trichomonas vaginalis glucosylceramidase, putative 0.0281 0.8114 1
Mycobacterium tuberculosis Probable cold-shock DeaD-box protein A homolog DeaD (ATP-dependent RNA helicase dead homolog) 0.0199 0.552 1
Trichomonas vaginalis conserved hypothetical protein 0.0051 0.0872 0.1008
Trichomonas vaginalis chromobox protein, putative 0.0072 0.1524 0.1818
Giardia lamblia Translation initiation factor eIF-4A, putative 0.0199 0.552 1
Schistosoma mansoni hypothetical protein 0.0073 0.1567 0.1606
Loa Loa (eye worm) hypothetical protein 0.0156 0.4173 0.412
Schistosoma mansoni gabp alpha 0.0071 0.1511 0.1549
Echinococcus multilocularis metallo beta lactamase domain containing protein 0.0051 0.0872 0.0872
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0036 0.0389 0.0409
Echinococcus multilocularis serine protein kinase ATM 0.0025 0.006 0.006
Trichomonas vaginalis glucosylceramidase, putative 0.0195 0.5386 0.6612
Onchocerca volvulus Putative hydrolase PNKD 0.0051 0.0872 0.1161
Trichomonas vaginalis beta lactamase domain, putative 0.0051 0.0872 0.1008
Entamoeba histolytica metallo-beta-lactamase family protein 0.0051 0.0872 0.1487
Plasmodium falciparum cytosolic glyoxalase II 0.0051 0.0872 0.0848
Brugia malayi latrophilin 2 splice variant baaae 0.0073 0.1567 0.1554
Brugia malayi ethe1-prov protein 0.0051 0.0872 0.0837
Trypanosoma brucei hydroxyacylglutathione hydrolase, putative 0.0051 0.0872 0.1487
Loa Loa (eye worm) hypothetical protein 0.0051 0.0872 0.0643
Schistosoma mansoni chromobox protein 0.0072 0.1524 0.1562
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0283 0.8175 0.8175
Echinococcus multilocularis geminin 0.0174 0.4751 0.4751
Schistosoma mansoni DEAD box ATP-dependent RNA helicase 0.0199 0.552 0.5658
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0085 0.194 0.782
Echinococcus multilocularis chromobox protein 1 0.0072 0.1524 0.1524
Trichomonas vaginalis glucosylceramidase, putative 0.0185 0.5073 0.6225
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0281 0.8114 0.8306
Entamoeba histolytica type A flavoprotein, putative 0.0051 0.0872 0.1487
Mycobacterium tuberculosis Conserved protein 0.0051 0.0872 0.0848
Trichomonas vaginalis glucosylceramidase, putative 0.0281 0.8114 1
Toxoplasma gondii LsmAD domain-containing protein 0.0049 0.0812 0.1378
Schistosoma mansoni cellular tumor antigen P53 0.005 0.0841 0.0862

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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