Detailed information for compound 1213710

Basic information

Technical information
  • TDR Targets ID: 1213710
  • Name: N-(3-bromophenyl)-4-[4-(4-chlorophenyl)sulfon ylpiperazin-1-yl]-4-oxobutanamide
  • MW: 514.82 | Formula: C20H21BrClN3O4S
  • H donors: 1 H acceptors: 4 LogP: 2.4 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 2
  • SMILES: O=C(Nc1cccc(c1)Br)CCC(=O)N1CCN(CC1)S(=O)(=O)c1ccc(cc1)Cl
  • InChi: 1S/C20H21BrClN3O4S/c21-15-2-1-3-17(14-15)23-19(26)8-9-20(27)24-10-12-25(13-11-24)30(28,29)18-6-4-16(22)5-7-18/h1-7,14H,8-13H2,(H,23,26)
  • InChiKey: ZMPJPZTVJDMPJR-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(3-bromophenyl)-4-[4-(4-chlorophenyl)sulfonylpiperazin-1-yl]-4-oxo-butanamide
  • N-(3-bromophenyl)-4-[4-(4-chlorophenyl)sulfonyl-1-piperazinyl]-4-oxobutanamide
  • N-(3-bromophenyl)-4-[4-(4-chlorophenyl)sulfonylpiperazin-1-yl]-4-keto-butyramide
  • MLS000393605
  • SMR000247817
  • T5254618
  • ZINC02662926

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens ataxin 2 Starlite/ChEMBL No references
Homo sapiens ATPase family, AAA domain containing 5 Starlite/ChEMBL No references
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references
Homo sapiens lamin A/C Starlite/ChEMBL No references
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) intermediate filament tail domain-containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum Intermediate filament protein ifa-1, putative Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum Lamin-C, putative Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis lamin Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis musashi Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi Intermediate filament tail domain containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core Get druggable targets OG5_139225 All targets in OG5_139225
Schistosoma japonicum ko:K07611 lamin, putative Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni intermediate filament proteins Get druggable targets OG5_128723 All targets in OG5_128723
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus lamin Get druggable targets OG5_128723 All targets in OG5_128723
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Toxoplasma gondii hypothetical protein 0.0049 0.0198 0.4354
Loa Loa (eye worm) hypothetical protein 0.0048 0.019 0.033
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0053 0.022 0.1093
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0304 0.1798 0.6652
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0023 0.0033 0.066
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0104 0.0508
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0043 0.0159 0.0575
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0028 0.0135
Leishmania major DNA polymerase eta, putative 0.0022 0.0028 0.009
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0028 0.0135
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0089 0.045 1
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0144 0.0793 0.2927
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0023 0.0035 0.0699
Onchocerca volvulus 0.0056 0.0245 0.1004
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0052 0.0218 0.0379
Loa Loa (eye worm) hypothetical protein 0.0033 0.0095 0.0165
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0054 0.0226 0.0825
Treponema pallidum fructose-bisphosphate aldolase 0.0334 0.1983 1
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0081 0.0288
Echinococcus multilocularis peptidase Clp (S14 family) 0.0059 0.0258 0.0254
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0023 0.0033 0.066
Schistosoma mansoni protein phosphatase 2C 0.007 0.0332 0.1655
Loa Loa (eye worm) hypothetical protein 0.0077 0.0371 0.0645
Onchocerca volvulus 0.0082 0.0406 0.2086
Mycobacterium ulcerans DNA polymerase IV 0.0022 0.0028 0.0031
Onchocerca volvulus 0.0082 0.0406 0.2086
Schistosoma mansoni hypothetical protein 0.0116 0.0616 0.3091
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0052 0.0218 0.1082
Loa Loa (eye worm) hypothetical protein 0.0935 0.5755 1
Brugia malayi intermediate filament protein 0.0033 0.0095 0.0165
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0089 0.045 1
Echinococcus granulosus intermediate filament protein 0.0033 0.0095 0.0338
Entamoeba histolytica hypothetical protein 0.0035 0.011 0.0433
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0068 0.0319 0.1168
Echinococcus granulosus lamin dm0 0.0033 0.0095 0.0338
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0022 0.0028 0.0123
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0023 0.0035 0.0699
Entamoeba histolytica Ran family GTPase 0.0023 0.0035 0.005
Brugia malayi Choline/Carnitine o-acyltransferase family protein 0.0082 0.0406 0.0705
Echinococcus multilocularis lamin dm0 0.0033 0.0095 0.0091
Trichomonas vaginalis DNA polymerase eta, putative 0.0022 0.0028 0.0014
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0045 0.0176 0.3853
Brugia malayi jmjC domain containing protein 0.007 0.0332 0.0576
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0059 0.0258 0.2793
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0052 0.0217 0.0793
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0028 0.0135
Schistosoma mansoni lamin 0.0033 0.0095 0.046
Brugia malayi PHD-finger family protein 0.0031 0.0082 0.0143
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0052 0.0218 0.0795
Echinococcus granulosus tumor protein p63 0.0386 0.2309 0.855
Schistosoma mansoni methyl-cpg binding protein mbd 0.0018 0.0006 0.0014
Echinococcus multilocularis musashi 0.0033 0.0095 0.0091
Echinococcus granulosus muscleblind protein 0.0331 0.1969 0.7288
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0028 0.0135
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0024 0.0044 0.004
Trypanosoma brucei DNA polymerase IV, putative 0.0022 0.0028 0.0135
Schistosoma mansoni intermediate filament proteins 0.0033 0.0095 0.046
Schistosoma mansoni importin beta-1 0.0031 0.0087 0.0419
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0045 0.0176 0.3853
Echinococcus granulosus carnitine O palmitoyltransferase 1 liver 0.0448 0.27 1
Brugia malayi Latrophilin receptor protein 2 0.0054 0.0226 0.0393
Echinococcus granulosus dna polymerase eta 0.0022 0.0028 0.009
Schistosoma mansoni hypothetical protein 0.0205 0.1174 0.5909
Echinococcus granulosus dna polymerase kappa 0.0022 0.0028 0.009
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0334 0.1983 1
Brugia malayi hypothetical protein 0.0035 0.011 0.0191
Trichomonas vaginalis set domain proteins, putative 0.027 0.1586 0.7974
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0081 0.0288
Brugia malayi ImpB/MucB/SamB family protein 0.0022 0.0028 0.0049
Loa Loa (eye worm) hypothetical protein 0.0252 0.147 0.2555
Echinococcus granulosus methyl CpG binding domain protein 2 0.0018 0.0006 0.001
Loa Loa (eye worm) isocitrate dehydrogenase 0.0018 0.0004 0.0006
Echinococcus multilocularis geminin 0.0205 0.1174 0.1171
Plasmodium falciparum JmjC domain-containing protein, putative 0.007 0.0332 0.7339
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0081 0.1742
Brugia malayi hypothetical protein 0.003 0.0081 0.0142
Loa Loa (eye worm) hypothetical protein 0.0031 0.0087 0.0151
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0081 0.1742
Entamoeba histolytica hypothetical protein 0.0025 0.005 0.0125
Echinococcus granulosus lysine specific demethylase 5A 0.0266 0.1557 0.576
Entamoeba histolytica hypothetical protein 0.0035 0.011 0.0433
Schistosoma mansoni lamin 0.0033 0.0095 0.046
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.0028 0.009
Brugia malayi Bromodomain containing protein 0.0085 0.0423 0.0734
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0022 0.0028 0.0024
Schistosoma mansoni hypothetical protein 0.0334 0.1984 1
Echinococcus granulosus choline O acetyltransferase 0.0082 0.0406 0.1492
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0023 0.0035 0.0061
Trypanosoma cruzi choline/carnitine O-acyltransferase, putative 0.0448 0.27 1
Trypanosoma cruzi hypothetical protein, conserved 0.0082 0.0406 0.1492
Echinococcus granulosus zinc finger protein 0.0025 0.0046 0.0157
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0028 0.0135
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0264 0.1544 0.5712
Echinococcus multilocularis jumonji domain containing 1A 0.007 0.0332 0.0328
Schistosoma mansoni zinc finger protein 0.0025 0.0046 0.0214
Loa Loa (eye worm) hypothetical protein 0.0331 0.1969 0.3421
Loa Loa (eye worm) hypothetical protein 0.0169 0.0951 0.1653
Plasmodium falciparum histone acetyltransferase GCN5 0.0039 0.0137 0.2991
Trypanosoma cruzi importin beta-1 subunit, putative 0.0025 0.005 0.017
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0334 0.1984 0.3448
Plasmodium falciparum importin beta, putative 0.0031 0.0087 0.1858
Echinococcus multilocularis snurportin 1 0.0334 0.1984 0.1981
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0052 0.0218 0.1082
Brugia malayi jmjC domain containing protein 0.0264 0.1544 0.2683
Loa Loa (eye worm) choline O-acetyltransferase 0.0082 0.0406 0.0705
Trypanosoma cruzi hypothetical protein, conserved 0.0082 0.0406 0.1492
Echinococcus multilocularis importin subunit beta 1 0.0031 0.0087 0.0083
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0045 0.0176 0.0769
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0023 0.0033 0.0325
Loa Loa (eye worm) hypothetical protein 0.0089 0.045 0.0783
Brugia malayi Choline/Carnitine o-acyltransferase family protein 0.0935 0.5755 1
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0163 0.0913 1
Brugia malayi jmjC domain containing protein 0.007 0.0332 0.0576
Schistosoma mansoni jumonji domain containing protein 0.0264 0.1544 0.7778
Giardia lamblia Histone acetyltransferase GCN5 0.0039 0.0137 0.0573
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0081 0.0398 0.0691
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0304 0.1798 1
Brugia malayi exodeoxyribonuclease III family protein 0.0021 0.0025 0.0044
Schistosoma mansoni hypothetical protein 0.0205 0.1174 0.5909
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.007 0.0332 0.1655
Echinococcus granulosus importin subunit beta 1 0.0031 0.0087 0.0308
Schistosoma mansoni peptidase Clp (S14 family) 0.0089 0.045 0.2256
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0334 0.1983 1
Schistosoma mansoni choline o-acyltransferase 0.0082 0.0406 0.2031
Echinococcus granulosus JmjC domain containing protein 4 0.007 0.0332 0.1216
Schistosoma mansoni phd/f-box containing protein 0.007 0.0332 0.1655
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0023 0.0033 0.0187
Trichomonas vaginalis bromodomain-containing protein, putative 0.0045 0.0176 0.0769
Trypanosoma cruzi carnitine/choline acetyltransferase, putative 0.0082 0.0406 0.1492
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0304 0.1798 0.6652
Trypanosoma cruzi carnitine/choline acetyltransferase, putative 0.0082 0.0406 0.1492
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0033 0.0096 0.0344
Onchocerca volvulus 0.0034 0.0104 0.0063
Loa Loa (eye worm) PHD-finger family protein 0.0022 0.0031 0.0054
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.0028 0.009
Echinococcus multilocularis tumor protein p63 0.0386 0.2309 0.2306
Schistosoma mansoni bromodomain containing protein 0.0072 0.0343 0.1713
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0334 0.1983 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0052 0.0218 0.0379
Onchocerca volvulus 0.0082 0.0406 0.2086
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0054 0.0226 0.0223
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0054 0.0226 0.0825
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0163 0.0913 1
Trypanosoma brucei importin beta-1 subunit, putative 0.0031 0.0087 0.0463
Echinococcus granulosus phd:f box containing protein 0.007 0.0332 0.1216
Loa Loa (eye worm) acetyltransferase 0.0148 0.0822 0.1428
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0043 0.0159 0.0575
Loa Loa (eye worm) hypothetical protein 0.007 0.0332 0.0576
Trypanosoma cruzi choline/carnitine O-acetyltransferase, putative 0.0082 0.0406 0.1492
Echinococcus granulosus lysine specific demethylase 6a 0.007 0.0332 0.1216
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0052 0.0218 0.0214
Trypanosoma brucei DNA polymerase IV, putative 0.0022 0.0028 0.0135
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0022 0.0028 0.0014
Trypanosoma brucei DNA polymerase eta, putative 0.0022 0.0028 0.0135
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0031 0.0083 0.0298
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0334 0.1983 1
Loa Loa (eye worm) jmjC domain-containing protein 0.007 0.0332 0.0576
Loa Loa (eye worm) hypothetical protein 0.0252 0.147 0.2555
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0052 0.0218 0.1082
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0033 0.0095 0.0165
Loa Loa (eye worm) hypothetical protein 0.0331 0.1969 0.3421
Echinococcus granulosus GPCR family 2 0.0054 0.0226 0.0825
Echinococcus granulosus GTP binding nuclear protein Ran 0.0023 0.0035 0.0116
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0022 0.0028 0.009
Echinococcus multilocularis dna polymerase eta 0.0022 0.0028 0.0024
Brugia malayi Pre-SET motif family protein 0.0238 0.138 0.2399
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0089 0.045 1
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0059 0.0258 0.2551
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0021 0.0025 0.008
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0144 0.0793 0.4401
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0034 0.0104 0.2252
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.011 0.0537
Leishmania major mitochondrial DNA polymerase beta 0.0304 0.1798 0.6652
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0021 0.0025 0.0022
Echinococcus multilocularis lysine specific demethylase 6a 0.007 0.0332 0.0328
Mycobacterium tuberculosis Conserved hypothetical protein 0.0022 0.0028 0.0267
Trypanosoma brucei hypothetical protein, conserved 0.0023 0.0033 0.0164
Trypanosoma cruzi hypothetical protein, conserved 0.0082 0.0406 0.1492
Echinococcus granulosus fetal alzheimer antigen falz 0.0024 0.0044 0.0149
Entamoeba histolytica hypothetical protein 0.0023 0.0033 0.0041
Schistosoma mansoni methyl-cpg binding protein mbd 0.0018 0.0006 0.0014
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0089 0.045 0.4791
Brugia malayi hypothetical protein 0.002 0.0014 0.0024
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0021 0.0025 0.008
Trypanosoma brucei carnitine O-acetyltransferase, putative 0.0082 0.0406 0.2242
Brugia malayi Importin beta-1 subunit 0.0031 0.0087 0.0151
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.011 0.0394
Leishmania major GTP-binding protein, putative 0.0023 0.0035 0.0116
Echinococcus multilocularis lamin 0.0033 0.0095 0.0091
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0031 0.0083 0.1786
Loa Loa (eye worm) hypothetical protein 0.0081 0.0398 0.0691
Loa Loa (eye worm) hypothetical protein 0.007 0.0332 0.0576
Leishmania major carnitine/choline acetyltransferase, putative 0.0082 0.0406 0.1492
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.0025 0.0482
Toxoplasma gondii LsmAD domain-containing protein 0.003 0.0081 0.1742
Giardia lamblia DINP protein human, muc B family 0.0022 0.0028 0.0014
Schistosoma mansoni choline o-acyltransferase 0.0082 0.0406 0.2031
Onchocerca volvulus 0.0082 0.0406 0.2086
Echinococcus granulosus peptidase Clp S14 family 0.0059 0.0258 0.0941
Loa Loa (eye worm) hypothetical protein 0.0042 0.0151 0.0263
Trypanosoma brucei carnitine O-palmitoyltransferase II, putative 0.0082 0.0406 0.2242
Brugia malayi Cytochrome P450 family protein 0.0056 0.024 0.0417
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0072 0.0345 0.0341
Echinococcus granulosus histone lysine methyltransferase setb 0.0053 0.022 0.0803
Loa Loa (eye worm) hypothetical protein 0.0053 0.022 0.0383
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0052 0.0218 0.0214
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0334 0.1983 1
Echinococcus granulosus L aminoadipate semialdehyde 0.0081 0.0398 0.1461
Mycobacterium ulcerans DNA polymerase IV 0.0022 0.0028 0.0031
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0054 0.0226 0.0223
Echinococcus granulosus histone acetyltransferase KAT2B 0.0142 0.078 0.2879
Toxoplasma gondii histone lysine demethylase JMJD6a 0.007 0.0332 0.7339
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0021 0.0025 0.0237
Schistosoma mansoni ran 0.0023 0.0035 0.0158
Schistosoma mansoni hypothetical protein 0.0054 0.0226 0.1124
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0053 0.022 0.0217
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0089 0.045 0.2172
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0028 0.0135
Brugia malayi Calcitonin receptor-like protein seb-1 0.0169 0.0951 0.1653
Brugia malayi jmjC domain containing protein 0.007 0.0332 0.0576
Trypanosoma cruzi carnitine O-palmitoyltransferase II, putative 0.0082 0.0406 0.1492
Brugia malayi jmjC domain containing protein 0.0266 0.1557 0.2706
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0021 0.0025 0.008
Brugia malayi Choline O-acetyltransferase 0.0082 0.0406 0.0705
Giardia lamblia Fructose-bisphosphate aldolase 0.0334 0.1983 1
Leishmania major phosphopantetheinyl transferase-like protein 0.0023 0.0033 0.0109
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0334 0.1983 1
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.0025 0.0482
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0053 0.022 0.1093
Leishmania major hypothetical protein, conserved 0.007 0.0332 0.1216
Entamoeba histolytica deoxycytidyl transferase, putative 0.0022 0.0028 0.0014
Plasmodium vivax SET domain protein, putative 0.0034 0.0104 0.2252
Brugia malayi Muscleblind-like protein 0.0331 0.1969 0.3421
Trypanosoma cruzi choline/carnitine O-acyltransferase, putative 0.0448 0.27 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.0028 0.009
Loa Loa (eye worm) latrophilin receptor protein 2 0.0054 0.0226 0.0393
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0018 0.0006 0.0003
Brugia malayi Probable ClpP-like protease 0.0089 0.045 0.0783
Echinococcus multilocularis muscleblind protein 0.0331 0.1969 0.1966
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0023 0.0035 0.005
Brugia malayi hypothetical protein 0.0252 0.147 0.2555
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0043 0.0159 0.0864
Loa Loa (eye worm) choline/Carnitine O-acyltransferase 0.0082 0.0406 0.0705
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0023 0.0033 0.066
Trypanosoma brucei PAB1-binding protein , putative 0.003 0.0081 0.0434
Loa Loa (eye worm) jmjC domain-containing protein 0.007 0.0332 0.0576
Schistosoma mansoni ran 0.0023 0.0035 0.0158
Trypanosoma brucei hypothetical protein, conserved 0.0082 0.0406 0.2242
Brugia malayi Isocitrate dehydrogenase 0.0018 0.0004 0.0006
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0023 0.0033 0.009
Leishmania major DNA polymerase kappa, putative 0.0022 0.0028 0.009
Mycobacterium tuberculosis Conserved hypothetical protein 0.016 0.0895 0.9807
Onchocerca volvulus 0.027 0.1586 1
Schistosoma mansoni ap endonuclease 0.0021 0.0025 0.0109
Plasmodium vivax ataxin-2 like protein, putative 0.003 0.0081 0.1742
Trichomonas vaginalis ran, putative 0.0023 0.0035 0.005
Toxoplasma gondii HEAT repeat-containing protein 0.0031 0.0087 0.1858
Loa Loa (eye worm) hypothetical protein 0.0116 0.0616 0.107
Echinococcus multilocularis JmjC domain containing protein 4 0.007 0.0332 0.0328
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0023 0.0035 0.0061
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0031 0.0083 0.0572
Loa Loa (eye worm) bromodomain containing protein 0.0023 0.0033 0.0057
Onchocerca volvulus Huntingtin homolog 0.0252 0.147 0.9222
Loa Loa (eye worm) hypothetical protein 0.0032 0.0091 0.0158
Echinococcus granulosus carnitine O palmitoyltransferase 2 0.0082 0.0406 0.1492
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0023 0.0035 0.0116
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0089 0.045 1
Brugia malayi Choline O-acetyltransferase 0.0082 0.0406 0.0705
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0052 0.0218 0.0795
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0238 0.138 0.2399
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0081 0.0398 0.1989
Trypanosoma cruzi hypothetical protein, conserved 0.0082 0.0406 0.1492
Schistosoma mansoni hypothetical protein 0.0054 0.0226 0.1124
Echinococcus multilocularis phd:f box containing protein 0.007 0.0332 0.0328
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0169 0.0951 0.1653
Loa Loa (eye worm) hypothetical protein 0.007 0.0332 0.0576
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0023 0.0035 0.0116
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0054 0.0226 0.0393
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0072 0.0345 0.1264
Loa Loa (eye worm) jmjC domain-containing protein 0.0266 0.1557 0.2706
Brugia malayi jmjC domain containing protein 0.007 0.0332 0.0576
Toxoplasma gondii exonuclease III APE 0.0021 0.0025 0.0482
Plasmodium vivax importin-beta 2, putative 0.0031 0.0087 0.1858
Echinococcus granulosus geminin 0.0205 0.1174 0.4339
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0022 0.0028 0.0267
Trypanosoma cruzi DNA polymerase eta, putative 0.0022 0.0028 0.009
Schistosoma mansoni phosphatidylserine receptor 0.007 0.0332 0.1655
Schistosoma mansoni jumonji/arid domain-containing protein 0.0266 0.1557 0.7844
Echinococcus granulosus lamin 0.0033 0.0095 0.0338
Echinococcus multilocularis GPCR, family 2 0.0054 0.0226 0.0223
Loa Loa (eye worm) hypothetical protein 0.0054 0.0226 0.0393
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0089 0.045 0.4791
Onchocerca volvulus 0.0081 0.0398 0.203
Trichomonas vaginalis importin beta-1, putative 0.0025 0.005 0.0125
Echinococcus granulosus histone acetyltransferase KAT2B 0.0045 0.0176 0.0638
Echinococcus granulosus snurportin 1 0.0334 0.1984 0.7344
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0334 0.1983 1
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0059 0.0258 0.2793
Echinococcus multilocularis dna polymerase kappa 0.0022 0.0028 0.0024
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0022 0.0028 0.0049
Loa Loa (eye worm) hypothetical protein 0.0022 0.0028 0.0049
Schistosoma mansoni ap endonuclease 0.0021 0.0025 0.0109
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0043 0.0159 0.0575
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.007 0.0332 0.7339
Echinococcus multilocularis lysine specific demethylase 5A 0.0264 0.1544 0.1541
Schistosoma mansoni hypothetical protein 0.0054 0.0226 0.1124
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0023 0.0035 0.0174
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0024 0.0044 0.0202
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0039 0.0135 0.0486
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0045 0.0176 0.3853
Loa Loa (eye worm) cytochrome P450 family protein 0.0056 0.024 0.0417
Mycobacterium ulcerans hypothetical protein 0.016 0.0895 0.9803
Brugia malayi Intermediate filament tail domain containing protein 0.0033 0.0095 0.0165
Toxoplasma gondii hypothetical protein 0.0031 0.0083 0.1786
Leishmania major choline/Carnitine o-acyltransferase-like protein 0.0448 0.27 1
Loa Loa (eye worm) carnitine O-palmitoyltransferase I isoform 0.0082 0.0406 0.0705
Brugia malayi isocitrate dehydrogenase 0.0018 0.0004 0.0006
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0334 0.1983 1
Loa Loa (eye worm) hypothetical protein 0.0056 0.0245 0.0425
Brugia malayi ImpB/MucB/SamB family protein 0.0022 0.0028 0.0049
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0334 0.1983 1
Schistosoma mansoni jumonji/arid domain-containing protein 0.0266 0.1557 0.7844
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0089 0.045 0.0447
Echinococcus granulosus jumonji domain containing 1A 0.007 0.0332 0.1216
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0028 0.0135
Schistosoma mansoni DNA polymerase eta 0.0022 0.0028 0.0123
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0144 0.0793 0.2927
Leishmania major hypothetical protein, conserved 0.003 0.0081 0.0288
Trypanosoma brucei importin beta-1 subunit, putative 0.0031 0.0087 0.0463
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0089 0.045 0.1656
Entamoeba histolytica acetyltransferase, GNAT family 0.0039 0.0137 0.0573
Brugia malayi Pre-SET motif family protein 0.0034 0.0104 0.0181
Leishmania major importin beta-1 subunit, putative 0.0025 0.005 0.017
Echinococcus multilocularis zinc finger protein 0.0025 0.0046 0.0042
Entamoeba histolytica hypothetical protein 0.0035 0.011 0.0433
Loa Loa (eye worm) hypothetical protein 0.0082 0.0406 0.0705
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.005 0.0125
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0023 0.0033 0.066
Trypanosoma brucei unspecified product 0.0022 0.0028 0.0135
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0089 0.045 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0028 0.0135
Trypanosoma brucei DNA polymerase IV, putative 0.0022 0.0028 0.0135
Trypanosoma cruzi carnitine O-acetyltransferase, putative 0.0082 0.0406 0.1492
Schistosoma mansoni terminal deoxycytidyl transferase 0.0022 0.0028 0.0123
Brugia malayi Bromodomain containing protein 0.0045 0.0173 0.0301
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0021 0.0025 0.0044
Schistosoma mansoni hypothetical protein 0.0035 0.011 0.0537
Echinococcus multilocularis carnitine O palmitoyltransferase 1, liver 0.0448 0.27 0.2698
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0028 0.0135
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.007 0.0332 0.1216
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.011 0.0106
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0023 0.0035 0.0699
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0034 0.0104 0.0508
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0163 0.0913 1
Brugia malayi RNA, U transporter 1 0.0089 0.0448 0.0779
Echinococcus multilocularis muscleblind protein 1 0.0331 0.1969 0.1966
Loa Loa (eye worm) jmjC domain-containing protein 0.007 0.0332 0.0576
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0021 0.0025 0.008
Schistosoma mansoni jumonji domain containing protein 0.007 0.0332 0.1655
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0021 0.0025 0.012
Leishmania major carnitine palmitoyltransferase-like protein 0.0082 0.0406 0.1492
Loa Loa (eye worm) hypothetical protein 0.003 0.0081 0.0142
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0068 0.0319 0.0315
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0089 0.045 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.0028 0.009
Trypanosoma brucei carnitine O-palmitoyltransferase, putative 0.0082 0.0406 0.2242
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0264 0.1544 0.1541
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.005 0.0125
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0034 0.0104 0.0101
Plasmodium vivax JmjC domain containing protein 0.007 0.0332 0.7339
Trypanosoma brucei carnitine O-palmitoyltransferase II, putative 0.0082 0.0406 0.2242
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0023 0.0035 0.0031
Trypanosoma cruzi choline/carnitine O-acyltransferase, putative 0.0082 0.0406 0.1492
Brugia malayi acetyltransferase, GNAT family protein 0.0148 0.0822 0.1428
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0089 0.045 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0334 0.1983 1
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.007 0.0332 0.1827
Schistosoma mansoni hypothetical protein 0.0054 0.0226 0.1124
Echinococcus multilocularis carnitine O palmitoyltransferase 2 0.0082 0.0406 0.0402
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0148 0.0822 0.0818
Loa Loa (eye worm) hypothetical protein 0.005 0.0203 0.0352
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0028 0.0135
Schistosoma mansoni hypothetical protein 0.0022 0.0031 0.0137
Echinococcus multilocularis L aminoadipate semialdehyde 0.0081 0.0398 0.0394
Brugia malayi latrophilin 2 splice variant baaae 0.0116 0.0616 0.107
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.007 0.0332 0.1216
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0039 0.0135 0.0131
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0023 0.0033 0.009
Trypanosoma cruzi hypothetical protein, conserved 0.0082 0.0406 0.1492
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0023 0.0033 0.0041
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0148 0.0822 0.4131
Entamoeba histolytica hypothetical protein 0.0035 0.011 0.0433
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0169 0.0951 0.1653
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0022 0.0028 0.009
Echinococcus multilocularis choline O acetyltransferase 0.0082 0.0406 0.0402
Loa Loa (eye worm) intermediate filament protein 0.0033 0.0095 0.0165
Schistosoma mansoni cellular tumor antigen P53 0.0056 0.0245 0.1217
Brugia malayi Choline/Carnitine o-acyltransferase family protein 0.0082 0.0406 0.0705
Onchocerca volvulus Huntingtin homolog 0.0252 0.147 0.9222
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0089 0.045 0.4744
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0031 0.0083 0.1786

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 24.88288501 um PUBCHEM_BIOASSAY: Dose Response Confirmation for Calpain Inhibitors. (Class of assay: confirmatory) [Related pubchem assays: 1236 (Primary screen preceding this confirmatory assay.)] ChEMBL. No reference
Potency (functional) 0.3981 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 0.5221 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 8.9125 um PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 11.2202 um PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 14.581 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 16.3601 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 20.5962 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human alpha-Glucosidase as a Potential Chaperone Treatment of Pompe Disease. (Class of assay: confirmatory) [Related pubchem assays: 997 ] ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Activators of Human alpha-Glucosidase as a Potential Chaperone Treatment of Pompe Disease. (Class of assay: confirmatory) [Related pubchem assays: 1467, 2100, 2112, 1473, 1466 ] ChEMBL. No reference
Potency (functional) = 28.1838 um PUBCHEM_BIOASSAY: Counterscreen qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. This assay monitors tau fibrillation by fluorescence polarization (FP) of Alexa 594-labeled K18 P301L, which does not fibrillize readily but incorporates into growing filaments of unlabeled tau. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent). (Class of assay: confirmatory) [Related pubchem assays: 2158 (Confirmation qHTS Assay for Inhibitors of Cruzain), 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1478 (qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent))] ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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