Detailed information for compound 1230670

Basic information

Technical information
  • TDR Targets ID: 1230670
  • Name: 2-[[4-(3,5-dimethylpiperidin-1-yl)sulfonylben zoyl]amino]thiophene-3-carboxamide
  • MW: 421.534 | Formula: C19H23N3O4S2
  • H donors: 2 H acceptors: 4 LogP: 3.07 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC1CC(C)CN(C1)S(=O)(=O)c1ccc(cc1)C(=O)Nc1sccc1C(=O)N
  • InChi: 1S/C19H23N3O4S2/c1-12-9-13(2)11-22(10-12)28(25,26)15-5-3-14(4-6-15)18(24)21-19-16(17(20)23)7-8-27-19/h3-8,12-13H,9-11H2,1-2H3,(H2,20,23)(H,21,24)
  • InChiKey: WWFOTYGKDHOKDL-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 2-[[4-[(3,5-dimethyl-1-piperidyl)sulfonyl]benzoyl]amino]thiophene-3-carboxamide
  • 2-[[[4-[(3,5-dimethyl-1-piperidinyl)sulfonyl]phenyl]-oxomethyl]amino]-3-thiophenecarboxamide
  • 2-[[4-(3,5-dimethylpiperidin-1-yl)sulfonylphenyl]carbonylamino]thiophene-3-carboxamide
  • MLS000529734
  • SMR000127216

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Escherichia coli penicillin-binding protein Starlite/ChEMBL No references
Homo sapiens microtubule-associated protein tau Starlite/ChEMBL No references
Homo sapiens TAR DNA binding protein Starlite/ChEMBL No references
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references
Homo sapiens lysine (K)-specific methyltransferase 2A Starlite/ChEMBL No references
Homo sapiens neuropeptide S receptor 1 Starlite/ChEMBL No references
Rattus norvegicus Inositol monophosphatase 1 Starlite/ChEMBL No references
Homo sapiens multiple endocrine neoplasia I No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma japonicum Menin, putative Get druggable targets OG5_133913 All targets in OG5_133913
Echinococcus multilocularis tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus granulosus tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni mixed-lineage leukemia protein mll Get druggable targets OG5_130642 All targets in OG5_130642
Schistosoma mansoni hypothetical protein Get druggable targets OG5_133913 All targets in OG5_133913
Schistosoma mansoni inositol monophosphatase Get druggable targets OG5_126810 All targets in OG5_126810
Trichomonas vaginalis inositol monophosphatase, putative Get druggable targets OG5_126810 All targets in OG5_126810
Schistosoma japonicum ko:K09188 myeloid/lymphoid or mixed-lineage leukemia protein 3, putative Get druggable targets OG5_130642 All targets in OG5_130642
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Leishmania donovani myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Brugia malayi Inositol-1 Get druggable targets OG5_126810 All targets in OG5_126810
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative Get druggable targets OG5_126810 All targets in OG5_126810
Leishmania mexicana myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Neospora caninum hypothetical protein Get druggable targets OG5_126810 All targets in OG5_126810
Echinococcus multilocularis dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Trypanosoma brucei gambiense inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). Get druggable targets OG5_126810 All targets in OG5_126810
Mycobacterium tuberculosis Possible penicillin-binding protein Get druggable targets OG5_149948 All targets in OG5_149948
Echinococcus granulosus inositol monophosphatase 1 Get druggable targets OG5_126810 All targets in OG5_126810
Entamoeba histolytica myo-inositol monophosphatase, putative Get druggable targets OG5_126810 All targets in OG5_126810
Neospora caninum Multidomain chromatinic protein with the following architecture: 3x PHD-bromo-3xPHD-SET domain and associated cysteine cluster a Get druggable targets OG5_130642 All targets in OG5_130642
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Echinococcus multilocularis neuropeptide receptor A26 Get druggable targets OG5_136011 All targets in OG5_136011
Echinococcus granulosus dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Schistosoma mansoni inositol monophosphatase Get druggable targets OG5_126810 All targets in OG5_126810
Echinococcus granulosus neuropeptide receptor A26 Get druggable targets OG5_136011 All targets in OG5_136011
Mycobacterium ulcerans extragenic suppressor protein SuhB Get druggable targets OG5_126810 All targets in OG5_126810
Leishmania braziliensis myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Loa Loa (eye worm) inositol-1 Get druggable targets OG5_126810 All targets in OG5_126810
Schistosoma japonicum ko:K01092 myo-inositol-1(or 4)-monophosphatase [EC3.1.3.25], putative Get druggable targets OG5_126810 All targets in OG5_126810
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Loa Loa (eye worm) TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma japonicum ko:K04380 microtubule-associated protein tau, putative Get druggable targets OG5_133504 All targets in OG5_133504
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus multilocularis inositol monophosphatase 1 Get druggable targets OG5_126810 All targets in OG5_126810
Trypanosoma congolense inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Trichomonas vaginalis myo inositol monophosphatase, putative Get druggable targets OG5_126810 All targets in OG5_126810
Echinococcus multilocularis microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Brugia malayi RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase Get druggable targets OG5_126810 All targets in OG5_126810
Trichomonas vaginalis myo inositol monophosphatase, putative Get druggable targets OG5_126810 All targets in OG5_126810
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Loa Loa (eye worm) RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi RNA recognition motif domain containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Leishmania infantum myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Schistosoma japonicum IPR000276,Rhodopsin-like GPCR superfamily,domain-containing Get druggable targets OG5_136011 All targets in OG5_136011
Echinococcus granulosus neuropeptide s receptor Get druggable targets OG5_136011 All targets in OG5_136011
Echinococcus multilocularis neuropeptide s receptor Get druggable targets OG5_136011 All targets in OG5_136011
Toxoplasma gondii histone lysine methyltransferase SET1 Get druggable targets OG5_130642 All targets in OG5_130642
Echinococcus granulosus microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB Get druggable targets OG5_126810 All targets in OG5_126810
Schistosoma mansoni microtubule-associated protein tau Get druggable targets OG5_133504 All targets in OG5_133504
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Entamoeba histolytica 3(2),5-bisphosphate nucleotidase, putative Inositol monophosphatase 1   277 aa 287 aa 22.3 %
Candida albicans one of two closely related genes similar to S. cerevisiae MET22/HAL2 (YOL064C) bisphosphate-3'-nucleotidase, implicated in salt Inositol monophosphatase 1   277 aa 306 aa 22.5 %
Schistosoma japonicum ko:K01082 3'(2'), 5'-bisphosphate nucleotidase [EC3.1.3.7], putative Inositol monophosphatase 1   277 aa 275 aa 21.5 %
Trypanosoma brucei inositol-1(or 4)-monophosphatase, putative Inositol monophosphatase 1   277 aa 304 aa 27.3 %
Trypanosoma congolense inositol-1(or 4)-monophosphatase, putative Inositol monophosphatase 1   277 aa 304 aa 28.9 %
Loa Loa (eye worm) hypothetical protein Inositol monophosphatase 1   277 aa 298 aa 23.8 %
Trichomonas vaginalis inositol monophosphatase, putative Inositol monophosphatase 1   277 aa 258 aa 21.7 %
Onchocerca volvulus Putative trans-2-enoyl-CoA reductase 1, mitochondrial Inositol monophosphatase 1   277 aa 278 aa 23.0 %
Candida albicans one of two closely related genes similar to S. cerevisiae MET22/HAL2 (YOL064C) bisphosphate-3'-nucleotidase, implicated in salt Inositol monophosphatase 1   277 aa 300 aa 22.0 %
Dictyostelium discoideum 3',5'-bisphosphate nucleotidase Inositol monophosphatase 1   277 aa 230 aa 25.2 %
Trichomonas vaginalis inositol monophosphatase, putative Inositol monophosphatase 1   277 aa 268 aa 22.4 %
Trichomonas vaginalis diphosphonucleoside phosphohydrolase, putative Inositol monophosphatase 1   277 aa 263 aa 21.7 %
Trypanosoma brucei gambiense inositol-1(or 4)-monophosphatase, putative Inositol monophosphatase 1   277 aa 309 aa 27.8 %
Schistosoma mansoni pap-inositol-14-phosphatase Inositol monophosphatase 1   277 aa 279 aa 22.9 %
Candida albicans one of two closely related genes similar to S. cerevisiae MET22/HAL2 (YOL064C) bisphosphate-3'-nucleotidase, implicated in salt Inositol monophosphatase 1   277 aa 307 aa 22.5 %
Onchocerca volvulus Inositol monophosphatase 1   277 aa 238 aa 22.7 %
Dictyostelium discoideum 3',5'-bisphosphate nucleotidase 1 Inositol monophosphatase 1   277 aa 275 aa 22.2 %
Trypanosoma cruzi myo-inositol-1 phosphatase, putative Inositol monophosphatase 1   277 aa 284 aa 30.6 %
Onchocerca volvulus Putative 28S ribosomal protein S10, mitochondrial Inositol monophosphatase 1   277 aa 271 aa 46.1 %
Entamoeba histolytica 3(2),5-bisphosphate nucleotidase, putative Inositol monophosphatase 1   277 aa 263 aa 24.0 %
Trypanosoma cruzi inositol polyphosphate 1-phosphatase, putative Inositol monophosphatase 1   277 aa 291 aa 23.7 %
Brugia malayi Inositol monophosphatase family protein Inositol monophosphatase 1   277 aa 238 aa 21.8 %
Trichomonas vaginalis myo inositol monophosphatase, putative Inositol monophosphatase 1   277 aa 276 aa 21.4 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium ulcerans 4-aminobutyrate aminotransferase 0.0072 0.068 0.1091
Brugia malayi hypothetical protein 0.0043 0.0365 0.1298
Echinococcus granulosus dna polymerase eta 0.0019 0.0098 0.0109
Schistosoma mansoni ornithine--oxo-acid transaminase 0.0072 0.068 0.076
Loa Loa (eye worm) hypothetical protein 0.0067 0.0624 0.2223
Mycobacterium tuberculosis Probable hydrolase 0.0043 0.0365 0.05
Plasmodium falciparum ataxin-2 like protein, putative 0.0053 0.0473 0.5091
Echinococcus multilocularis dnaJ subfamily B 0.0494 0.5259 0.5259
Echinococcus multilocularis ETS transcription factor Elf 2 0.0011 0.0017 0.0016
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0377 0.3966
Brugia malayi transcription factor E74 isoform 0.0011 0.0017 0.0057
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0098 0.0738
Trichomonas vaginalis acetylornithine aminotransferase, putative 0.051 0.5432 1
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.0899 0.1591
Echinococcus granulosus GA binding protein alpha chain 0.0079 0.0748 0.0836
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0076 0.0724 0.2579
Schistosoma mansoni microtubule-associated protein tau 0.0833 0.8947 1
Toxoplasma gondii ornithine aminotransferase, mitochondrial precursor, putative 0.0072 0.068 0.5912
Mycobacterium leprae PROBABLE GLUTAMATE-1-SEMIALDEHYDE 2,1-AMINOMUTASE HEML (GSA) (GLUTAMATE-1-SEMIALDEHYDE AMINOTRANSFERASE) (GSA-AT) 0.0072 0.068 0.0693
Chlamydia trachomatis glutamate-1-semialdehyde-2,1-aminomutase 0.0072 0.068 0.5
Loa Loa (eye worm) latrophilin receptor protein 2 0.0017 0.008 0.0282
Loa Loa (eye worm) hypothetical protein 0.0043 0.0365 0.1299
Loa Loa (eye worm) inositol-1 0.0045 0.0377 0.1343
Loa Loa (eye worm) hypothetical protein 0.0011 0.0017 0.0057
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0098 0.0738
Echinococcus granulosus neuropeptide s receptor 0.0558 0.596 0.6661
Brugia malayi N-terminal motif family protein 0.0202 0.2088 0.7444
Mycobacterium ulcerans beta-lactamase 0.0043 0.0365 0.05
Brugia malayi Inositol-1 0.0045 0.0377 0.1343
Schistosoma mansoni hypothetical protein 0.0017 0.008 0.0089
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0034 0.0266 0.0266
Schistosoma mansoni DNA polymerase eta 0.0019 0.0098 0.011
Loa Loa (eye worm) hypothetical protein 0.0011 0.0017 0.0057
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0724 0.0809
Loa Loa (eye worm) hypothetical protein 0.0202 0.2088 0.7444
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.0899 0.1591
Mycobacterium leprae PROBABLE ADENOSYLMETHIONINE-8-AMINO-7-OXONONANOATE AMINOTRANSFERASE BIOA 0.051 0.5432 1
Echinococcus granulosus histone lysine methyltransferase setb 0.0034 0.0266 0.0297
Mycobacterium ulcerans glutaminase 0.0268 0.2805 0.5074
Loa Loa (eye worm) hypothetical protein 0.0043 0.0365 0.1299
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0724 0.0809
Echinococcus multilocularis ets variant gene 4 0.0011 0.0017 0.0016
Schistosoma mansoni hypothetical protein 0.0024 0.0153 0.0171
Echinococcus granulosus protein C ets 2 0.0011 0.0017 0.0018
Toxoplasma gondii histone lysine methyltransferase SET1 0.0116 0.115 1
Echinococcus granulosus mixed lineage leukemia protein mll 0.0016 0.0069 0.0076
Schistosoma mansoni fyve finger-containing phosphoinositide kinase fyv1 0.001 0.0001 0.0001
Echinococcus granulosus ETS transcription factor Elf 2 0.0011 0.0017 0.0018
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0266 0.0298
Brugia malayi Fli-1 protein 0.0239 0.249 0.8879
Mycobacterium tuberculosis Probable aminotransferase 0.051 0.5432 1
Mycobacterium ulcerans lipase LipD 0.0043 0.0365 0.05
Plasmodium falciparum ornithine aminotransferase 0.0072 0.068 1
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0365 0.06
Schistosoma mansoni glutaminase 0.0268 0.2805 0.3135
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0093 0.0899 0.0898
Trypanosoma cruzi polo-like protein kinase, putative 0.0093 0.0899 1
Echinococcus multilocularis Aminotransferase class III 0.0072 0.068 0.068
Onchocerca volvulus 0.0264 0.276 1
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0098 0.0105
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0043 0.0365 0.1299
Echinococcus multilocularis tar DNA binding protein 0.0076 0.0724 0.0723
Trypanosoma brucei hypothetical protein, conserved 0.0043 0.0365 0.3825
Leishmania major hypothetical protein, conserved 0.0034 0.0258 0.1995
Echinococcus granulosus GPCR family 2 0.0017 0.008 0.0089
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0724 0.0809
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.002 0.0109 0.0121
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0096 0.0936 0.0936
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0232 0.2413 0.8605
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0043 0.0365 0.05
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0017 0.008 0.0089
Echinococcus multilocularis cpg binding protein 0.0064 0.0587 0.0586
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0098 0.0738
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0098 0.0098
Loa Loa (eye worm) fli-1 protein 0.0239 0.249 0.8879
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0093 0.0899 0.3203
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0096 0.0936 0.1046
Entamoeba histolytica hypothetical protein 0.0043 0.0365 0.3328
Schistosoma mansoni z-protein (S1r protein) 0.001 0.0001 0.0001
Plasmodium vivax hypothetical protein, conserved 0.0043 0.0365 0.2536
Schistosoma mansoni cpg binding protein 0.006 0.0549 0.0614
Entamoeba histolytica serine/threonine protein kinase, putative 0.0093 0.0899 1
Onchocerca volvulus 0.0043 0.0365 0.1321
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0079 0.0748 0.2666
Brugia malayi Augmenter of liver regeneration 0.0034 0.0258 0.0917
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0098 0.0738
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0365 0.0408
Trichomonas vaginalis CAMK family protein kinase 0.0046 0.0391 0.0648
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0365 0.0408
Echinococcus granulosus neuropeptide receptor A26 0.0558 0.596 0.6661
Echinococcus multilocularis ETS transcription factor Elf 2 0.0011 0.0017 0.0016
Brugia malayi Pre-SET motif family protein 0.0034 0.0266 0.0948
Echinococcus granulosus FAD linked sulfhydryl oxidase ALR 0.0034 0.0258 0.0288
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 0.0034 0.0258 0.1995
Trichomonas vaginalis set domain proteins, putative 0.0264 0.276 0.5042
Brugia malayi RNA binding protein 0.0076 0.0724 0.2579
Schistosoma mansoni hypothetical protein 0.0017 0.008 0.0089
Loa Loa (eye worm) hypothetical protein 0.0043 0.0365 0.1299
Trichomonas vaginalis esterase, putative 0.0043 0.0365 0.06
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0266 0.0298
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.0899 0.1591
Schistosoma mansoni elf1 0.0011 0.0017 0.0019
Loa Loa (eye worm) hepatopoietin HPO2 0.0034 0.0258 0.0917
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0365 0.06
Schistosoma mansoni hypothetical protein 0.0195 0.2015 0.2253
Schistosoma mansoni dep domain containing protein 0.001 0.0001 0.0001
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0034 0.0266 0.2312
Entamoeba histolytica hypothetical protein 0.0043 0.0365 0.3328
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0365 0.06
Schistosoma mansoni serine/threonine protein kinase 0.0093 0.0899 0.1005
Mycobacterium tuberculosis Conserved protein 0.0043 0.0365 0.05
Echinococcus granulosus dnaJ subfamily B 0.0494 0.5259 0.5878
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.0899 0.1591
Echinococcus multilocularis neuropeptide receptor A26 0.0558 0.596 0.596
Toxoplasma gondii Erv1 / Alr family protein 0.0034 0.0258 0.2238
Echinococcus multilocularis GPCR, family 2 0.0017 0.008 0.0079
Plasmodium vivax SET domain protein, putative 0.0034 0.0266 0.0203
Mycobacterium ulcerans hypothetical protein 0.051 0.5432 1
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0724 0.0809
Echinococcus granulosus Aminotransferase class III 0.0072 0.068 0.076
Brugia malayi Latrophilin receptor protein 2 0.0017 0.008 0.0282
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0045 0.0377 0.3276
Onchocerca volvulus Serine\/threonine kinase homolog 0.0093 0.0899 0.3255
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0096 0.0936 0.3336
Plasmodium falciparum ataxin-2 like protein, putative 0.0053 0.0473 0.5091
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0365 0.06
Brugia malayi glutaminase DH11.1 0.0268 0.2805 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0098 0.0738
Brugia malayi Calcitonin receptor-like protein seb-1 0.0054 0.0484 0.1725
Loa Loa (eye worm) CXXC zinc finger family protein 0.006 0.0549 0.1957
Onchocerca volvulus 0.0034 0.0266 0.0963
Mycobacterium leprae Probable Acetylornithine aminotransferase ArgD 0.0072 0.068 0.0693
Mycobacterium ulcerans hypothetical protein 0.0043 0.0365 0.05
Mycobacterium tuberculosis Conserved protein 0.0043 0.0365 0.05
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0017 0.008 0.0079
Mycobacterium ulcerans L-lysine aminotransferase 0.0072 0.068 0.1091
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0011 0.0017 0.0057
Schistosoma mansoni hypothetical protein 0.0011 0.0017 0.0019
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0043 0.0365 0.05
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0043 0.0365 0.1299
Loa Loa (eye worm) hypothetical protein 0.0037 0.0297 0.1057
Mycobacterium ulcerans esterase/lipase LipP 0.0043 0.0365 0.05
Echinococcus granulosus cpg binding protein 0.0064 0.0587 0.0655
Mycobacterium ulcerans adenosylmethionine-8-amino-7-oxononanoate aminotransferase 0.051 0.5432 1
Mycobacterium ulcerans 4-aminobutyrate aminotransferase 0.0072 0.068 0.1091
Brugia malayi CXXC zinc finger family protein 0.006 0.0549 0.1957
Mycobacterium leprae Probable 4-aminobutyrate aminotransferase GabT (GAMMA-AMINO-N-BUTYRATE TRANSAMINASE) (GABA TRANSAMINASE) (GLUTAMATE:SUCCINIC SEM 0.0072 0.068 0.0693
Echinococcus granulosus inositol monophosphatase 1 0.0045 0.0377 0.0421
Loa Loa (eye worm) hypothetical protein 0.0017 0.008 0.0282
Echinococcus granulosus ornithine aminotransferase 0.0072 0.068 0.076
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.0365 0.0408
Echinococcus multilocularis ETS transcription factor Elf 1 0.0011 0.0017 0.0016
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0278 0.2911 0.5273
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0043 0.0365 0.05
Brugia malayi 4-aminobutyrate aminotransferase, mitochondrial precursor 0.0072 0.068 0.2423
Trichomonas vaginalis glutaminase, putative 0.0268 0.2805 0.5126
Mycobacterium ulcerans ornithine aminotransferase RocD1 and RocD2 0.0072 0.068 0.1091
Echinococcus multilocularis GA binding protein alpha chain 0.0079 0.0748 0.0748
Schistosoma mansoni dishevelled 0.001 0.0001 0.0001
Brugia malayi Pre-SET motif family protein 0.0232 0.2413 0.8605
Schistosoma mansoni hypothetical protein 0.0011 0.0017 0.0019
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0098 0.0738
Loa Loa (eye worm) glutaminase 2 0.0268 0.2805 1
Loa Loa (eye worm) D-ets-2 protein 0.0011 0.0017 0.0057
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0098 0.0738
Brugia malayi hypothetical protein 0.0053 0.0473 0.1684
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0045 0.0377 0.0623
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0032 0.0239 0.0266
Schistosoma mansoni regulator of G protein signaling 0.001 0.0001 0.0001
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.004 0.0326 0.0428
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0093 0.0899 0.1004
Echinococcus granulosus beta LACTamase domain containing family member 0.0043 0.0365 0.0407
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 0.0034 0.0258 0.1995
Brugia malayi Ets-domain containing protein 0.0079 0.0748 0.2666
Schistosoma mansoni inositol monophosphatase 0.0045 0.0377 0.0422
Echinococcus granulosus microtubule associated protein 2 0.0833 0.8947 1
Loa Loa (eye worm) hypothetical protein 0.0043 0.0365 0.1299
Loa Loa (eye worm) hypothetical protein 0.0034 0.0266 0.0948
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0093 0.0899 1
Wolbachia endosymbiont of Brugia malayi acetylornithine transaminase protein 0.0072 0.068 1
Echinococcus multilocularis dna polymerase eta 0.0019 0.0098 0.0098
Echinococcus multilocularis neuropeptide s receptor 0.0558 0.596 0.596
Brugia malayi beta-lactamase family protein 0.0043 0.0365 0.1299
Schistosoma mansoni kinase 0.0047 0.0404 0.0452
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0129 0.1299 0.1452
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0096 0.0936 0.1046
Schistosoma mansoni gabp alpha 0.0079 0.0748 0.0836
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0034 0.0266 0.0266
Onchocerca volvulus 0.0043 0.0365 0.1321
Mycobacterium tuberculosis Probable glutamate-1-semialdehyde 2,1-aminomutase HemL (GSA) (glutamate-1-semialdehyde aminotransferase) (GSA-at) 0.0072 0.068 0.1091
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0377 0.3485
Schistosoma mansoni ets-related 0.0011 0.0017 0.0019
Brugia malayi beta-lactamase 0.0043 0.0365 0.1299
Mycobacterium tuberculosis Probable esterase LipL 0.0043 0.0365 0.05
Trichomonas vaginalis inositol monophosphatase, putative 0.0045 0.0377 0.0623
Loa Loa (eye worm) hypothetical protein 0.0043 0.0365 0.1299
Schistosoma mansoni hypothetical protein 0.0017 0.008 0.0089
Echinococcus multilocularis protein C ets 2 0.0011 0.0017 0.0016
Mycobacterium tuberculosis Probable lipase LipE 0.0043 0.0365 0.05
Brugia malayi beta-lactamase family protein 0.0043 0.0365 0.1299
Schistosoma mansoni hypothetical protein 0.0037 0.0297 0.0332
Loa Loa (eye worm) hypothetical protein 0.0043 0.0365 0.1299
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0098 0.0109
Echinococcus granulosus geminin 0.0195 0.2015 0.2252
Loa Loa (eye worm) hypothetical protein 0.0019 0.0098 0.0348
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0096 0.0936 0.0936
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0098 0.011
Mycobacterium tuberculosis Probable L-lysine-epsilon aminotransferase Lat (L-lysine aminotransferase) (lysine 6-aminotransferase) 0.0072 0.068 0.1091
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0016 0.0069 0.0068
Brugia malayi F/Y-rich N-terminus family protein 0.002 0.0106 0.0377
Brugia malayi hypothetical protein 0.0034 0.0267 0.0951
Entamoeba histolytica hypothetical protein 0.0043 0.0365 0.3328
Echinococcus granulosus ETS transcription factor Elf 1 0.0011 0.0017 0.0018
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0024 0.0153 0.0152
Mycobacterium tuberculosis Adenosylmethionine-8-amino-7-oxononanoate aminotransferase BioA 0.051 0.5432 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0098 0.0738
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0098 0.0348
Schistosoma mansoni cpg binding protein 0.0064 0.0587 0.0656
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.0365 0.0364
Plasmodium vivax ataxin-2 like protein, putative 0.0053 0.0473 0.5091
Loa Loa (eye worm) hypothetical protein 0.0054 0.0484 0.1725
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0377 0.3485
Echinococcus granulosus ETS domain containing protein Elk 1 0.0011 0.0017 0.0018
Toxoplasma gondii ABC1 family protein 0.0043 0.0365 0.317
Onchocerca volvulus 0.006 0.0549 0.1989
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0724 0.0809
Trypanosoma brucei unspecified product 0.0019 0.0098 0.0738
Echinococcus multilocularis ETS transcription factor Elf 5 0.0011 0.0017 0.0016
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0098 0.0738
Schistosoma mansoni hypothetical protein 0.0195 0.2015 0.2253
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0016 0.0069 0.0068
Onchocerca volvulus 0.0043 0.0365 0.1321
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0098 0.0098
Loa Loa (eye worm) TAR-binding protein 0.0076 0.0724 0.2579
Echinococcus multilocularis microtubule associated protein 2 0.0833 0.8947 0.8947
Brugia malayi Ets-domain containing protein 0.0011 0.0017 0.0057
Brugia malayi Ets-domain containing protein 0.0079 0.0748 0.2666
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.002 0.0109 0.0108
Echinococcus multilocularis ornithine aminotransferase 0.0072 0.068 0.068
Entamoeba histolytica hypothetical protein 0.0043 0.0365 0.3328
Schistosoma mansoni dishevelled 0.001 0.0001 0.0001
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0017 0.008 0.0282
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0096 0.0936 0.3336
Brugia malayi latrophilin 2 splice variant baaae 0.0037 0.0297 0.1057
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0017 0.008 0.0089
Leishmania major hypothetical protein, conserved 0.0053 0.0473 0.468
Brugia malayi DNA-binding protein D-ETS-3 0.0011 0.0017 0.0057
Trypanosoma cruzi PAB1-binding protein , putative 0.0053 0.0473 0.468
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0096 0.0936 0.1046
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0365 0.3333
Mycobacterium leprae conserved hypothetical protein 0.0043 0.0365 0.0076
Leishmania major hypothetical protein, conserved 0.0043 0.0365 0.3333
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0098 0.0738
Schistosoma mansoni inositol monophosphatase 0.0045 0.0377 0.0422
Trypanosoma brucei polo-like protein kinase 0.0093 0.0899 1
Echinococcus multilocularis FAD linked sulfhydryl oxidase ALR 0.0034 0.0258 0.0257
Schistosoma mansoni cpg binding protein 0.0064 0.0587 0.0656
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.0899 0.1591
Schistosoma mansoni hypothetical protein 0.0043 0.0365 0.0408
Loa Loa (eye worm) glutaminase 0.0268 0.2805 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0054 0.0484 0.1725
Toxoplasma gondii LsmAD domain-containing protein 0.0053 0.0473 0.4108
Brugia malayi serine/threonine-protein kinase plk-2 0.0093 0.0899 0.3203
Schistosoma mansoni hypothetical protein 0.0017 0.008 0.0089
Schistosoma mansoni ets-related 0.0239 0.249 0.2783
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0377 0.3485
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.0098 0.0738
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0098 0.0738
Echinococcus granulosus ETS transcription factor Elf 5 0.0011 0.0017 0.0018
Trypanosoma cruzi PAB1-binding protein , putative 0.0053 0.0473 0.468
Mycobacterium tuberculosis Probable acetylornithine aminotransferase ArgD 0.0072 0.068 0.1091
Echinococcus multilocularis beta LACTamase domain containing family member 0.0043 0.0365 0.0364
Trypanosoma cruzi ERV/ALR sulfhydryl oxidase domain-containing protein 0.0034 0.0258 0.1995
Loa Loa (eye worm) beta-lactamase 0.0043 0.0365 0.1299
Echinococcus granulosus tar DNA binding protein 0.0076 0.0724 0.0808
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0096 0.0936 0.1046
Toxoplasma gondii Erv1 / Alr family protein 0.0034 0.0258 0.2238
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0098 0.0348
Mycobacterium tuberculosis Probable lipase LipD 0.0043 0.0365 0.05
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0098 0.0105
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0045 0.0377 0.0623
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0365 0.06
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0054 0.0484 0.1725
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0043 0.0365 0.05
Mycobacterium tuberculosis Probable ornithine aminotransferase (N-terminus part) RocD1 (ornithine--oxo-acid aminotransferase) 0.0072 0.068 0.1091
Mycobacterium tuberculosis Conserved protein 0.0043 0.0365 0.05
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0045 0.0377 0.0523
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.0899 0.1591
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0034 0.0266 0.0298
Giardia lamblia Kinase, PLK 0.0093 0.0899 1
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0016 0.0069 0.0076
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0202 0.2088 0.7565
Echinococcus multilocularis ETS domain containing protein Elk 1 0.0011 0.0017 0.0016
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0365 0.3333
Brugia malayi RNA recognition motif domain containing protein 0.0076 0.0724 0.2579
Trichomonas vaginalis CAMK family protein kinase 0.0046 0.0391 0.0648
Echinococcus multilocularis inositol monophosphatase 1 0.0045 0.0377 0.0377
Schistosoma mansoni ets 0.0011 0.0017 0.0019
Loa Loa (eye worm) histone methyltransferase 0.002 0.0109 0.0387
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0024 0.0153 0.017
Mycobacterium ulcerans glutamate-1-semialdehyde aminotransferase 0.0072 0.068 0.1091
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0098 0.0738
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0016 0.0069 0.0077
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0098 0.011
Mycobacterium leprae Probable lipase LipE 0.0043 0.0365 0.0076
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.0365 0.0407
Schistosoma mansoni polyomavirus enhancer activator 3 pea3 0.0011 0.0017 0.0019
Brugia malayi TAR-binding protein 0.0076 0.0724 0.2579
Echinococcus granulosus ETS transcription factor Elf 2 0.0011 0.0017 0.0018
Mycobacterium ulcerans acetylornithine aminotransferase 0.0072 0.068 0.1091
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0045 0.0377 0.3485
Echinococcus multilocularis ornithine aminotransferase 0.0072 0.068 0.068
Plasmodium vivax ornithine aminotransferase, putative 0.0072 0.068 1
Loa Loa (eye worm) hypothetical protein 0.0053 0.0473 0.1684
Loa Loa (eye worm) ets-domain-containing protein 0.0011 0.0017 0.0057
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.0899 0.1591
Echinococcus multilocularis ewsr:fli fusion protein type 0.0011 0.0017 0.0016
Trypanosoma cruzi polo-like protein kinase, putative 0.0093 0.0899 1
Trypanosoma brucei PAB1-binding protein , putative 0.0053 0.0473 0.5073
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0017 0.008 0.0079
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0098 0.0738
Loa Loa (eye worm) DNA-binding protein D-ETS-3 0.0011 0.0017 0.0057
Schistosoma mansoni hypothetical protein 0.0494 0.5259 0.5878
Echinococcus granulosus dna polymerase kappa 0.0019 0.0098 0.0109
Echinococcus multilocularis geminin 0.0195 0.2015 0.2015
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0098 0.0348
Echinococcus granulosus ewsr:fli fusion protein type 0.0011 0.0017 0.0018
Trypanosoma brucei ERV/ALR sulfhydryl oxidase domain-containing protein 0.0034 0.0258 0.2586
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0266 0.0298
Loa Loa (eye worm) RNA binding protein 0.0076 0.0724 0.2579
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0096 0.0936 0.1046

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 1.9953 um PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 2.8184 um PUBCHEM_BIOASSAY: qHTS Assay for Identifying the Cell-Membrane Permeable IMPase Inhibitors: Potentiation with Lithium. (Class of assay: confirmatory) [Related pubchem assays: 901 ] ChEMBL. No reference
Potency (functional) = 3.1623 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 6.3096 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference
Potency (functional) 7.0795 uM PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 10.4179 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 13.1154 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 18.3564 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) = 19.9526 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) 20.5962 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 29.0929 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Assay for Enhancers of SMN2 Splice Variant Expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Vif-A3F Interactions: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase). (Class of assay: confirmatory) [Related pubchem assays: 2429 (Confirmation qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2407 (Probe Development Summary for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2427 (Thermal Shift Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase))] ChEMBL. No reference
Potency (functional) 39.8107 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 50.1187 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] ChEMBL. No reference
Potency (functional) 79.4328 uM PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.